Patents by Inventor Zubin Gagrat

Zubin Gagrat has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PURIFICATION OF SULFONATED DNA
    Publication number: 20240026341
    Abstract: The present disclosure provides methods and systems for purification of chemically modified, specifically, sulfonated DNA. Additionally, the disclosure provides methods and systems for bisulfite conversion with improved purification of sulfonated DNA using silica supports, such as silica beads, and acidic conditions for binding sulfonated DNA to silica surfaces.
    Type: Application
    Filed: July 29, 2021
    Publication date: January 25, 2024
    Inventors: Evan M. Ragland, Zubin Gagrat, Michael J. Domanico
  • Normalization of polymerase activity
    Patent number: 11708603
    Abstract: Provided herein is technology relating to the amplification-based detection of nucleic acids and particularly, but not exclusively, to methods and compositions for minimizing variability in the activity between different samples or manufacturing lots of DNA polymerases, such as Taq DNA polymerase.
    Type: Grant
    Filed: February 11, 2021
    Date of Patent: July 25, 2023
    Assignee: Exact Sciences Corporation
    Inventors: Hatim Allawi, Rebecca Oldham-Haltom, Zubin Gagrat, Michael Domanico, Graham Lidgard
  • STRUCTURE AND TEMPERATURE-DEPENDENT FLAP ENDONUCLEASE SUBSTRATES
    Publication number: 20230046033
    Abstract: 5? hairpin oligonucleotide substrates for reversible repression, e.g., by temperature shift, of cleavage by flap endonucleases, and methods using 5? hairpin oligonucleotides.
    Type: Application
    Filed: September 16, 2020
    Publication date: February 16, 2023
    Inventors: Zubin Gagrat, Michael B. Matter, Nicholas J. Domanico, Michael J. Domanico
  • NORMALIZATION OF POLYMERASE ACTIVITY
    Publication number: 20210189462
    Abstract: Provided herein is technology relating to the amplification-based detection of nucleic acids and particularly, but not exclusively, to methods and compositions for minimizing variability in the activity between different samples or manufacturing lots of DNA polymerases, such as Taq DNA polymerase.
    Type: Application
    Filed: February 11, 2021
    Publication date: June 24, 2021
    Inventors: Hatim Allawi, Rebecca Oldham-Haltom, Zubin Gagrat, Michael Domanico, Graham Lidgard
  • Normalization of polymerase activity
    Patent number: 10954556
    Abstract: Provided herein is technology relating to the amplification-based detection of nucleic acids and particularly, but not exclusively, to methods and compositions for minimizing variability in the activity between different samples or manufacturing lots of DNA polymerases, such as Taq DNA polymerase.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: March 23, 2021
    Inventors: Hatim Allawi, Rebecca Oldham-Haltom, Zubin Gagrat, Michael Domanico, Graham Lidgard
  • NORMALIZATION OF POLYMERASE ACTIVITY
    Publication number: 20190153510
    Abstract: Provided herein is technology relating to the amplification-based detection of nucleic acids and particularly, but not exclusively, to methods and compositions for minimizing variability in the activity between different samples or manufacturing lots of DNA polymerases, such as Taq DNA polymerase.
    Type: Application
    Filed: September 18, 2018
    Publication date: May 23, 2019
    Inventors: Hatim Allawi, Rebecca Oldham-Haltom, Zubin Gagrat, Michael Domanico, Graham Lidgard
  • Normalization of polymerase activity
    Patent number: 10106844
    Abstract: Provided herein is technology relating to the amplification-based detection of nucleic acids and particularly, but not exclusively, to methods and compositions for minimizing variability in the activity between different samples or manufacturing lots of DNA polymerases, such as Taq DNA polymerase.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: October 23, 2018
    Assignee: Exact Sciences Development Company, LLC
    Inventors: Hatim Allawi, Rebecca Oldham-Haltom, Zubin Gagrat, Michael Domanico, Graham Lidgard
  • NORMALIZATION OF POLYMERASE ACTIVITY
    Publication number: 20160060683
    Abstract: Provided herein is technology relating to the amplification-based detection of nucleic acids and particularly, but not exclusively, to methods and compositions for minimizing variability in the activity between different samples or manufacturing lots of DNA polymerases, such as Taq DNA polymerase.
    Type: Application
    Filed: November 12, 2015
    Publication date: March 3, 2016
    Inventors: Hatim Allawi, Rebecca Oldham-Haltom, Zubin Gagrat, Michael Domanico, Graham Lidgard
  • Normalization of polymerase activity
    Patent number: 9212392
    Abstract: Provided herein is technology relating to the amplification-based detection of nucleic acids and particularly, but not exclusively, to methods and compositions for minimizing variability in the activity between different samples or manufacturing lots of DNA polymerases, such as Taq DNA polymerase.
    Type: Grant
    Filed: September 25, 2013
    Date of Patent: December 15, 2015
    Inventors: Hatim Allawi, Rebecca Oldham-Haltom, Zubin Gagrat, Michael Domanico, Graham Lidgard
  • NORMALIZATION OF POLYMERASE ACTIVITY
    Publication number: 20140087382
    Abstract: Provided herein is technology relating to the amplification-based detection of nucleic acids and particularly, but not exclusively, to methods and compositions for minimizing variability in the activity between different samples or manufacturing lots of DNA polymerases, such as Taq DNA polymerase.
    Type: Application
    Filed: September 25, 2013
    Publication date: March 27, 2014
    Applicant: Exact Sciences Corporation
    Inventors: Hatim Allawi, Rebecca Oldham-Haltom, Zubin Gagrat, Michael Domanico, Graham Lidgard