Patents by Inventor Zvi Nevo
Zvi Nevo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220233578Abstract: Compositions and methods of using same for tissue regeneration are provided. Accordingly, there is provided a composition comprising a hyaluronic acid, a laminin polypeptide, an antioxidant and Copolymer 1 at a concentration range of 10-150 microgram/ml. Also provided is a composition comprising a hyaluronic acid, a laminin polypeptide and vitamin E at a concentration range of 0.3-30 mM. Also provided are matrices and hydrogels of the compositions and methods of using same.Type: ApplicationFiled: June 4, 2020Publication date: July 28, 2022Applicants: Ramot at Tel-Aviv University Ltd., The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Zvi NEVO, Shimon ROCHKIND
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Publication number: 20220226432Abstract: Deferred treatment of nerve injuries is provided. Accordingly, there is provided a method of deferred treatment of a nerve injury in a subject in need thereof, the method comprising implanting at least 1 week following onset or diagnosis of the nerve injury in the subject a composition comprising a hyaluronic acid, a laminin polypeptide and an antioxidant at or near the nerve injury of the subject.Type: ApplicationFiled: June 4, 2020Publication date: July 21, 2022Applicants: Ramot at Tel-Aviv University Ltd., The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Zvi NEVO, Shimon ROCHKIND
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Publication number: 20200390800Abstract: Methods of preventing or treating neurogenic shock are provided. Accordingly there is provided a method of treating neurogenic shock following nerve injury in a subject comprising implanting a composition comprising a hyaluronic acid, a laminin polypeptide and an antioxidant, at or near the nerve injury of the subject. Also provided is a method of preventing or treating neurogenic shock following nerve injury in a subject comprising implanting within 48 hours following the nerve injury a composition comprising a hyaluronic acid, a laminin polypeptide and an antioxidant, at or near the nerve injury of the subject.Type: ApplicationFiled: November 29, 2018Publication date: December 17, 2020Applicants: Ramot at Tel-Aviv University Ltd., The Medical Research, Infrastruture and Health Services Fund of the Tel Aviv Medecal CenterInventors: Shimon ROCHKIND, Zvi NEVO
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Patent number: 10729815Abstract: A combined treatment for nerve injury is provided. Accordingly there is provided a composition comprising a hyaluronic acid, a laminin polypeptide, an antioxidant and an anti-gliotic agent. Also provided are matrices and hydrogels of the composition and methods of using same.Type: GrantFiled: November 29, 2017Date of Patent: August 4, 2020Assignees: Ramot at Tel-Aviv University Ltd., The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Shimon Rochkind, Zvi Nevo
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Publication number: 20190117846Abstract: A combined treatment for nerve injury is provided. Accordingly there is provided a composition comprising a hyaluronic acid, a laminin polypeptide, an antioxidant and an anti-gliotic agent. Also provided are matrices and hydrogels of the composition and methods of using same.Type: ApplicationFiled: November 29, 2017Publication date: April 25, 2019Applicants: Ramot at Tel-Aviv University Ltd., The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Shimon ROCHKIND, Zvi NEVO
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Patent number: 10245351Abstract: Hybrid hydrogels formed of a plurality of peptides that are capable of self-assembling into a hydrogel in an aqueous solution and a biocompatible polymer that is characterized by high swelling capability, high elasticity and low mechanical strength are disclosed, with exemplary hybrid hydrogels being formed of a plurality of aromatic dipeptides and hyaluronic acid. The hybrid hydrogels are characterized by controllable mechanical and biological properties which can be adjusted by controlling the concentration ratio of the peptides and the polymer, and which average the mechanical and biological properties of the peptides and the polymer. Processes of preparing the hydrogels and uses thereof in pharmaceutical, cosmetic or cosmeceutic applications such as tissue engineering and/or regeneration are further disclosed.Type: GrantFiled: March 20, 2017Date of Patent: April 2, 2019Assignee: Technology Innovation Momentum Fund (Israel) Limited PartnershipInventors: Moran Aviv, Ludmila Buzhansky, Shmuel Einav, Zvi Nevo, Ehud Gazit, Lihi Adler-Abramovich
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Patent number: 10004761Abstract: A composition suitable for treating a variety of medical, aesthetic and cosmetic conditions in mucous membranes and occluded skin areas, comprising hyaluronic acid, N-acetylcysteine, an active agent and set to pH of less than 6, which is characterized by high in vivo stability, is disclosed, as well as uses thereof in temporally extended delivery of active agent to mucous membrane in bodily sites.Type: GrantFiled: June 21, 2017Date of Patent: June 26, 2018Inventors: Mark M. Levy, Zvi Nevo, Samuel Levin
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Publication number: 20170360822Abstract: A composition suitable for treating a variety of medical, aesthetic and cosmetic conditions in mucous membranes and occluded skin areas, comprising hyaluronic acid, N-acetylcysteine, an active agent and set to pH of less than 6, which is characterized by high in vivo stability, is disclosed, as well as uses thereof in temporally extended delivery of active agent to mucous membrane in bodily sites.Type: ApplicationFiled: June 21, 2017Publication date: December 21, 2017Inventors: Mark M. LEVY, Zvi NEVO, Samuel LEVIN
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Publication number: 20170189582Abstract: Hybrid hydrogels formed of a plurality of peptides that are capable of self-assembling into a hydrogel in an aqueous solution and a biocompatible polymer that is characterized by high swelling capability, high elasticity and low mechanical strength are disclosed, with exemplary hybrid hydrogels being formed of a plurality of aromatic dipeptides and hyaluronic acid. The hybrid hydrogels are characterized by controllable mechanical and biological properties which can be adjusted by controlling the concentration ratio of the peptides and the polymer, and which average the mechanical and biological properties of the peptides and the polymer. Processes of preparing the hydrogels and uses thereof in pharmaceutical, cosmetic or cosmeceutic applications such as tissue engineering and/or regeneration are further disclosed.Type: ApplicationFiled: March 20, 2017Publication date: July 6, 2017Applicant: Technology Innovation Momentum Fund (Israel) Limited PartnershipInventors: Moran AVIV, Ludmila BUZHANSKY, Shmuel EINAV, Zvi NEVO, Ehud GAZIT, Lihi ADLER-ABRAMOVICH
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Patent number: 9610353Abstract: Hybrid hydrogels formed of a plurality of peptides that are capable of self-assembling into a hydrogel in an aqueous solution and a biocompatible polymer that is characterized by high swelling capability, high elasticity and low mechanical strength are disclosed, with exemplary hybrid hydrogels being formed of a plurality of aromatic dipeptides and hyaluronic acid. The hybrid hydrogels are characterized by controllable mechanical and biological properties which can be adjusted by controlling the concentration ratio of the peptides and the polymer, and which average the mechanical and biological properties of the peptides and the polymer. Processes of preparing the hydrogels and uses thereof in pharmaceutical, cosmetic or cosmeceutic applications such as tissue engineering and/or regeneration are further disclosed.Type: GrantFiled: July 6, 2015Date of Patent: April 4, 2017Assignee: Technology Innovation Momentum Fund (Israel) Limited PartnershipInventors: Moran Aviv, Ludmila Buzhansky, Shmuel Einav, Zvi Nevo, Ehud Gazit, Lihi Adler-Abramovich
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Publication number: 20150306229Abstract: Hybrid hydrogels formed of a plurality of peptides that are capable of self-assembling into a hydrogel in an aqueous solution and a biocompatible polymer that is characterized by high swelling capability, high elasticity and low mechanical strength are disclosed, with exemplary hybrid hydrogels being formed of a plurality of aromatic dipeptides and hyaluronic acid. The hybrid hydrogels are characterized by controllable mechanical and biological properties which can be adjusted by controlling the concentration ratio of the peptides and the polymer, and which average the mechanical and biological properties of the peptides and the polymer. Processes of preparing the hydrogels and uses thereof in pharmaceutical, cosmetic or cosmeceutic applications such as tissue engineering and/or regeneration are further disclosed.Type: ApplicationFiled: July 6, 2015Publication date: October 29, 2015Applicant: Technology Innovation Momentum Fund (Israel) Limited PartnershipInventors: Moran AVIV, Ludmila BUZHANSKY, Shmuel EINAV, Zvi NEVO, Ehud GAZIT, Lihi ADLER-ABRAMOVICH
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Publication number: 20150283168Abstract: A chitosan composition which forms a hydrogel at near physiological pH and 37° C., comprising at least one type of chitosan having a degree of acetylation in the range of from about 30% to about 60%, and at least one type of chitosan having a degree of deacetylation of at least about 70% is disclosed. Further disclosed is a chitosan composition which forms a hydrogel at near physiological pH and 37° C., that includes at least one type of chitosan having a degree of deacetylation of at least about 70% and a molecular weight of from 10-4000 kDa, and at least one type of a chitosan having a molecular weight of from 200-20000 Da. Further disclosed are methods of preparation and uses of the chitosan compositions.Type: ApplicationFiled: April 30, 2015Publication date: October 8, 2015Inventors: Noah BEN-SHALOM, Zvi NEVO, Abraham PATCHORNIK, Dror ROBINSON
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Patent number: 9074095Abstract: Hybrid hydrogels formed of a plurality of peptides that are capable of self-assembling into a hydrogel in an aqueous solution and a biocompatible polymer that is characterized by high swelling capability, high elasticity and low mechanical strength are disclosed, with exemplary hybrid hydrogels being formed of a plurality of aromatic dipeptides and hyaluronic acid. The hybrid hydrogels are characterized by controllable mechanical and biological properties which can be adjusted by controlling the concentration ratio of the peptides and the polymer, and which average the mechanical and biological properties of the peptides and the polymer. Processes of preparing the hydrogels and uses thereof in pharmaceutical, cosmetic or cosmeceutic applications such as tissue engineering and/or regeneration are further disclosed.Type: GrantFiled: June 2, 2011Date of Patent: July 7, 2015Assignee: Technology Innovation Momentum Fund (Israel) Limited PartnershipInventors: Moran Aviv, Ludmila Buzhansky, Shmuel Einav, Zvi Nevo, Ehud Gazit, Lihi Adler-Abramovich
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Patent number: 9034348Abstract: A chitosan composition which forms a hydrogel at near physiological pH and 37° C., comprising at least one type of chitosan having a degree of acetylation in the range of from about 30% to about 60%, and at least one type of chitosan having a degree of deacetylation of at least about 70% is disclosed. Further disclosed is a chitosan composition which forms a hydrogel at near physiological pH and 37° C., that includes at least one type of chitosan having a degree of deacetylation of at least about 70% and a molecular weight of from 10-4000 kDa, and at least one type of a chitosan having a molecular weight of from 200-20000 Da. Further disclosed are methods of preparation and uses of the chitosan compositions.Type: GrantFiled: March 14, 2013Date of Patent: May 19, 2015Assignee: Chi2Gel Ltd.Inventors: Noah Ben-Shalom, Zvi Nevo, Abraham Patchornik, Dror Robinson
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Publication number: 20140315808Abstract: A method of treating a disease or condition in which up-regulating GAGs is therapeutically beneficial is disclosed. The method comprises locally administering to a subject a therapeutically effective amount of an agent capable of down-regulating activity or expression of a component of the renin-angiotensin system.Type: ApplicationFiled: June 30, 2014Publication date: October 23, 2014Inventors: Talia WEINSTEIN, Uzi GAFTER, Zvi NEVO, Dror ROBINSON, Zoharia EVRON
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Patent number: 8765678Abstract: A method of treating a disease or condition in which up-regulating GAGs is therapeutically beneficial is disclosed, in particular osteoarthritis and skin diseases. The method comprises locally administering to a subject a therapeutically effective amount of an agent capable of down-regulating activity or expression of a component of the renin-angiotensin system.Type: GrantFiled: July 27, 2006Date of Patent: July 1, 2014Assignee: Mor Research Applications Ltd.Inventors: Talia Weinstein, Uzi Gafter, Zvi Nevo, Dror Robinson, Zoharia Evron
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Publication number: 20140010850Abstract: Provided are method of generating a fiber from a globular protein such as albumin. Also provided are albumin fibers and fabrics and methods of using same for bonding a damaged tissue or for ex vivo or in vivo formation of a tissue.Type: ApplicationFiled: September 16, 2013Publication date: January 9, 2014Applicant: Technion Research & Development Foundation LimitedInventors: Eyal ZUSSMAN, David Simhon, Shmuel Chervinsky, Abraham Katzir, Zvi Nevo, Yael Dror
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Patent number: 8551948Abstract: Provided are method of generating a fiber from a globular protein such as albumin. Also provided are albumin fibers and fabrics and methods of using same for bonding a damaged tissue or for ex vivo or in vivo formation of a tissue.Type: GrantFiled: March 28, 2013Date of Patent: October 8, 2013Assignee: Technion Research & Development Foundation LimitedInventors: Eyal Zussman, David Simhon, Shmuel Chervinsky, Abraham Katzir, Zvi Nevo, Yael Dror
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Patent number: 8546333Abstract: Provided are method of generating a fiber from a globular protein such as albumin. Also provided are albumin fibers and fabrics and methods of using same for bonding a damaged tissue or for ex vivo or in vivo formation of a tissue.Type: GrantFiled: January 31, 2008Date of Patent: October 1, 2013Assignee: Technion Research & Development Foundation LimitedInventors: Eyal Zussman, David Simhon, Shmuel Chervinsky, Abraham Katzir, Zvi Nevo, Yael Dror
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Publication number: 20130244972Abstract: A chitosan composition which forms a hydrogel at near physiological pH and 37° C., comprising at least one type of chitosan having a degree of acetylation in the range of from about 30% to about 60%, and at least one type of chitosan having a degree of deacetylation of at least about 70% is disclosed. Further disclosed is a chitosan composition which forms a hydrogel at near physiological pH and 37° C., that includes at least one type of chitosan having a degree of deacetylation of at least about 70% and a molecular weight of from 10-4000 kDa, and at least one type of a chitosan having a molecular weight of from 200-20000 Da. Further disclosed are methods of preparation and uses of the chitosan compositions.Type: ApplicationFiled: March 14, 2013Publication date: September 19, 2013Applicant: MOR RESEARCH APPLICATIONS LTD.Inventors: Noah Ben-Shalom, Zvi Nevo, Abraham Patchornik, Dror Robinson