Implantable medical device for deployment across the atrioventricular septum
An implantable medical device (IMD) may be configured for deployment at a patient's atrioventricular septum in order to sense and/or pace a patient's heart. The atrioventricular septum of the patient's heart may have an atrial facing side defining part of the right atrium of the patient's heart and a ventricle facing side defining part of the left ventricle of the patient's heart. The IMD may include a first component configured to be positioned at least in part in the right atrium of the patient's heart proximate the atrioventricular septum, and a second component configured to be positioned at least in part in the left ventricle.
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This application claims the benefit of U.S. Provisional Patent Application Ser. No. 62/271,647 filed on Dec. 28, 2015, the disclosure of which is incorporated herein by reference.
TECHNICAL FIELDThe present disclosure generally relates to implantable medical devices, and more particularly, to implantable medical devices that are configured to be deployed across the atrioventricular septum.
BACKGROUNDImplantable medical devices are commonly used today to monitor a patient and/or deliver therapy to a patient. For example, implantable sensors are often used to monitor one or more physiological parameters of a patient, such as heart beats, heart sounds, ECG, respiration, etc. In some instances, pacing devices are used to treat patients suffering from various heart conditions that may result in a reduced ability of the heart to deliver sufficient amounts of blood to a patient's body. Such heart conditions may lead to slow, rapid, irregular, and/or inefficient heart contractions. To help alleviate some of these conditions, various medical devices (e.g., pacemakers, defibrillators, etc.) can be implanted in a patient's body. Such devices may monitor and in some cases provide electrical stimulation to the heart to help the heart operate in a more normal, efficient and/or safe manner. In some instances, it may be beneficial to sense and/or pace two or more chambers of the heart.
SUMMARYThis disclosure provides design, delivery and deployment method, and clinical usage alternatives for medical devices. An example implantable medical device (IMD) configured for deployment at a patient's atrioventricular septum in order to sense and/or pace a patient's heart is disclosed, the atrioventricular septum of the patient's heart having an atrial facing side defining part of the right atrium of the patient's heart and a ventricle facing side defining part of the left ventricle of the patient's heart. The IMD includes a first component that is configured to be positioned at least in part in the right atrium of the patient's heart proximate the atrioventricular septum once the IMD is implanted and that includes a housing, a power source disposed within the housing and circuitry disposed within the housing and operably coupled to the power source. The IMD includes a second component that is configured to be positioned at least in part in the left ventricle of the patient's heart once the IMD is implanted and that is mechanically coupled to the first component through a passage passing through the atrioventricular septum. The second component includes a housing and two or more electrodes for sensing and/or pacing the left ventricle of the patient's heart.
Alternatively or additionally to any of the embodiments above, the first component further includes two or more electrodes for sensing and/or pacing the right atrium of the patient's heart.
Alternatively or additionally to any of the embodiments above, the two or more electrodes of the second component are operably coupled to the circuitry of the first component.
Alternatively or additionally to any of the embodiments above, at least one of the two or more electrodes of the second component engage the ventricle facing side of the atrioventricular septum of the patient's heart once the IMD is implanted.
Alternatively or additionally to any of the embodiments above, at least one of the two or more electrodes of the first component engage the atrial facing side of the atrioventricular septum of the patient's heart once the IMD is implanted.
Alternatively or additionally to any of the embodiments above, the second component is configured to move from a contracted state to an expanded state, wherein during implantation of the IMD, the second component is configured to pass through the passage through the atrioventricular septum in the contracted state and then move to the expanded state once in the left ventricle of the patient's heart.
Alternatively or additionally to any of the embodiments above, wherein in the expanded state, the second component extends laterally beyond a lateral extent of the passage through the atrioventricular septum and engages the ventricle facing side of the atrioventricular septum of the patient's heart.
Alternatively or additionally to any of the embodiments above, the first component extends distally beyond a delivery catheter and engages the atrial facing side of the atrioventricular septum of the patient's heart once the IMD is implanted.
Alternatively or additionally to any of the embodiments above, the second component is configured to cut the passage through the atrioventricular septum while the IMD is implanted.
Alternatively or additionally to any of the embodiments above, the second component is mechanically coupled to the first component through the passage via a connecting member.
Alternatively or additionally to any of the embodiments above, the connecting member is part of the second component, and forms an interference fit with the first component.
Alternatively or additionally to any of the embodiments above, the connecting member is part of the first component, and forms an interference fit with the first component.
Alternatively or additionally to any of the embodiments above, the first component comprises a fixation element for securing the first component to the atrioventricular septum of the patient's heart.
Alternatively or additionally to any of the embodiments above, the second component comprises a fixation element for securing the second component to the atrioventricular septum of the patient's heart.
An implantable medical device (IMD) configured for deployment at a patient's atrioventricular septum is disclosed, the atrioventricular septum of the patient's heart having an atrial facing side defining part of the right atrium of the patient's heart and a ventricle facing side defining part of the left ventricle of the patient's heart. The IMD includes a body having a first end portion, a second end portion and a connecting portion connecting the first end portion to the second end portion. At least part of the first end portion may be configured to be positioned in the right atrium of the patient's heart proximate the atrioventricular septum once the IMD is implanted and at least part of the second end portion extends into the left ventricle of the patient's heart once the IMD is implanted. The connecting portion extends through a passage that passes through the atrioventricular septum and the second end portion extends laterally beyond a lateral extent of the connecting portion to engage the ventricle facing side of the atrioventricular septum of the patient's heart once the IMD is implanted.
Alternatively or additionally to any of the embodiments above, the second end portion includes two or more electrodes for sensing and/or pacing the left ventricle of the patient's heart, wherein at least one of the two or more electrodes of the second end portion engages the ventricle facing side of the atrioventricular septum of the patient's heart.
Alternatively or additionally to any of the embodiments above, the first end portion includes two or more electrodes for sensing and/or pacing the right atrium of the patient's heart, wherein at least one of the two or more electrodes of the first end portion engages the atrial facing side of the atrioventricular septum of the patient's heart.
Alternatively or additionally to any of the embodiments above, at least part of the second end portion is configured to move from a contracted state to an expanded state.
A method of deploying a leadless pacing and sensing assembly proximate a patient's atrioventricular septum is disclosed, the leadless pacing and sensing assembly including a right atrial leadless cardiac pacemaker (LCP) and a left ventricular leadless cardiac pacemaker (LCP). The method includes advancing a delivery catheter through the patient's vasculature until a distal end of the delivery catheter is proximate an atrial side of the atrioventricular septum, the right atrial LCP disposed within a distal region of the delivery catheter. A deployment device is advanced past the right atrial LCP and through the atrioventricular septum, the left ventricular LCP secured to the deployment device such that the left ventricular LCP passes past the right atrial LCP and is disposed proximate a ventricular side of the atrioventricular septum. The left ventricular LCP is secured to the right atrial LCP and the deployment device is withdrawn.
Alternatively or additionally to any of the embodiments above, the method further comprises withdrawing the delivery catheter.
The above summary is not intended to describe each embodiment or every implementation of the present disclosure. Advantages and attainments, together with a more complete understanding of the disclosure, will become apparent and appreciated by referring to the following description and claims taken in conjunction with the accompanying drawings.
The disclosure may be more completely understood in consideration of the following description of various illustrative embodiments in connection with the accompanying drawings, in which:
While the disclosure is amenable to various modifications and alternative forms, specifics thereof have been shown by way of example in the drawings and will be described in detail. It should be understood, however, that the intention is not to limit aspects of the disclosure to the particular illustrative embodiments described. On the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the disclosure.
DESCRIPTIONThe following description should be read with reference to the drawings in which similar elements in different drawings are numbered the same. The description and the drawings, which are not necessarily to scale, depict illustrative embodiments and are not intended to limit the scope of the disclosure.
All numbers are herein assumed to be modified by the term “about”, unless the content clearly dictates otherwise. The recitation of numerical ranges by endpoints includes all numbers subsumed within that range (e.g., 1 to 5 includes 1, 1.5, 2, 2.75, 3, 3.80, 4, and 5).
As used in this specification and the appended claims, the singular forms “a”, “an”, and “the” include the plural referents unless the content clearly dictates otherwise. As used in this specification and the appended claims, the term “or” is generally employed in its sense including “and/or” unless the content clearly dictates otherwise.
It is noted that references in the specification to “an embodiment”, “some embodiments”, “other embodiments”, etc., indicate that the embodiment described may include a particular feature, structure, or characteristic, but every embodiment may not necessarily include the particular feature, structure, or characteristic. Moreover, such phrases are not necessarily referring to the same embodiment. Further, when a particular feature, structure, or characteristic is described in connection with an embodiment, it is contemplated that the feature, structure, or characteristic may be applied to other embodiments whether or not explicitly described unless clearly stated to the contrary.
The present disclosure generally relates to implantable medical devices, and more particularly, to implantable medical devices that are configured to be deployed across the atrioventricular septum. More particularly, the present disclosure is directed at providing pacing and/or sensing from a position next to or within the atrioventricular septum. In order to call out particular features of the cardiac anatomy,
It will be appreciated that by traversing the AV septum 12 at or near the position indicated by the arrow 14, which is above the tricuspid valve TV and below the mitral valve MV, the left ventricle LV is accessible from the right atrium RA. This area can be reached, for example, via a transvenous catheter passing through either the SVC (superior vena cava) or the IVC (inferior vena cava) and into the right atrium RA. It will be appreciated that by deploying a two-part or multi-part LCP within the AV septum 12, it is possible to reach the left ventricle LV without having to potentially interfere with the mitral valve MV.
In some cases, the left seed 24 may be secured to a deployment mechanism 28 that can be used to advance the left seed 24 axially. The left seed 24 and the deployment mechanism 28 may be deployed within a hypotube 30 that may be configured to extend through the atrioventricular septum 12 (
Once deployed, the left seed 24 may be disposed at least partially on the ventricular side 18 of the AV septum 12, and the right seed 22 may be disposed at least partially on the atrial side 16 of the AV septum 12 (
In some cases, the central lumen 34 may also include one or more fixation elements (not explicitly shown) that are configured to engage with the left seed 24 and secure the left seed 24 to the right seed 22 once the left seed 24 has been deployed. The one or more fixation elements may, for example, extend to form a frictional engagement with the left seed 24. In some cases, the one or more fixation elements may be stent-like, and may expand to engage the left seed 24. In some instances, the one or more fixation elements may be formed of a shape memory material that can have a delivery shape that permits the left seed 24 to pass through the central lumen 34 of the right seed 22 and then revert to a “remembered” shape that engages the left seed 24 once the one or more fixation elements reach a particular temperature, for example. The one or more fixation elements could be formed from any of a variety of shape memory polymers or metals. In some cases, the one or more fixation elements may be formed of a nickel-titanium alloy such as Nitinol.
The right seed 22 includes, as illustrated, a first electrode 40 and a second electrode 42 that may be electrically coupled to internal circuitry within the right seed 22. While two electrodes 40, 42 are illustrated, it will be appreciated that the right seed 22 may include additional electrodes, depending on the desired pacing and/or sensing capabilities. In some cases, the first electrode 40 and the second electrode 42 may be disposed on the distal side of the right seed 22 such that both the first electrode 40 and the second electrode 42 may be in contact with the atrial side 16 of the AV septum 12 once implanted.
Once implanted, it will be appreciated that the connecting portion 58 will extend through a passage that passes across the AV septum 12. In some cases, the passage may be formed directly by the second end portion 56 being forced through the AV septum 12. In some instances, the passage may be formed by a separate needle, hypotube or other suitable device prior to inserting the second end portion 56. The second end portion 56 may extend laterally (e.g. lateral relative to the major axis of the connecting portion 58) beyond a lateral extent of the connecting portion 58 in order to engage the ventricle side 18 (
In some cases, as illustrated, the second end portion 56 may include electrodes for sensing and/or pacing the left ventricle LV. In some cases, the second end portion 56 may include a first electrode 60 and a second electrode 62 that are positioned on the second end portion 56 such that the first electrode 60 and the second electrode 62 are able to engage the ventricle side 18 of the AV septum 12. In some instances, the second end portion 56 may also include additional electrodes, but this is not required. In some cases, the first end portion 54 may include electrodes for sensing and/or pacing the right atrium RA. In some cases, the first end portion 54 may include a first electrode 64 and a second electrode 66 that are positioned on the first end portion 54 such that the first electrode 64 and the second electrode 66 are able to engage the atrial side 16 of the AV septum 12. In some instances, the first end portion 54 may also include additional electrodes, but this is not required.
The second component 74 may be mechanically coupled to the first component 72 through a passage passing through the AV septum 12. In some cases, the second component 74 is mechanically coupled to the first component 72 via a connecting member 82. In some cases, the connecting member 82 may be part of the second component 74 and may form an interference fit with the first component 72. In some cases, the connecting member 82 may be part of the first component 72 and may form an interference fit with the second component 74. In some cases, the first component 72 includes a fixation element for securing the first component 72 to the AV septum 12. In some instances, the second component 74 includes a fixation element for securing the second component 74 to the AV septum 12. Subsequent drawings will provides examples of such fixation elements, which may include one or more of barbs, spikes, pins, staples, threads, screws, helix, tines, and/or the like.
In some cases, the second component 74 may include a housing 84. The housing 84 may be a cylindrical body, for example. In some cases, the housing 84 may instead have another shape, or may simply be several insulated wires coupled together and including electrodes that are electrically coupled to the insulated wires, for example. In some instances, the housing 84 could be umbrella-shaped, with electrodes disposed at the tips of wires that may be joined together in a web. A first electrode 86 and a second electrode 88 may be disposed on the housing 84 and may be positioned such that the first electrode 86 and the second electrode 88 may be able to sense and/or pace the left ventricle LV of the heart. In some cases, the first electrode 86 and the second electrode 88 are configured to engage the ventricle side 18 (
In some cases, the first component 72 may include electrodes for sensing and/or pacing the right atrium RA. As illustrated, the first component 72 includes a first electrode 94 and a second electrode 96. In some cases, at least one of the first electrode 94 and the second electrode 96 may be positioned to engage the atrial side 16 (
In some instances, the second component 74 may be configured to move from a contracted state to an expanded state. In some cases, the second component 74 may pass through the passage formed in the AV septum 12 while in its contracted state and then move into its expanded state once the second component 74 has reached the left ventricle LV. In some cases, when in its expanded state, the second component 74 may extend laterally beyond a lateral extent of the passage through the AV septum 12 and may engage the ventricle side 18 (
In some cases, as illustrated, the LCP 100 may include a passage 122 that passes through the LCP 100 from a first side 124 of the housing 120 to a second side 126 of the housing 120. In some cases, the passage 122 is configured to allow the left seed 24 (
The electrodes 114 may be secured relative to the housing 120 but may be exposed to the tissue and/or blood surrounding the LCP 100. The electrodes 114 may generally conduct electrical signals to and from the LCP 100 and the surrounding tissue and/or blood. Such electrical signals can include communication pulses, electrical stimulation pulses, and intrinsic cardiac electrical signals. Intrinsic cardiac electrical signals may include electrical signals generated by the heart and may be represented by an electrocardiogram (ECG). The electrodes 114 can be made up of one or more biocompatible conductive materials such as various metals or alloys that are known to be safe for implantation within a human body. In some instances, the electrodes 114 may be generally disposed on either side of LCP 100 and may be in electrical communication with one or more of modules 102, 104, 106, 108, and 110. In examples where the electrodes 114 are secured directly to the housing 120, the electrodes 114 may have an insulative portion that electrically isolates the electrodes 114 from adjacent electrodes, the housing 120, and/or other portions of the LCP 100. Some or all of the electrodes 114 may be spaced from the housing 120 and connected to the housing 120 and/or other components of the LCP 100 through connecting wires or the like.
The electrodes 114 and/or 114′ may have any of a variety of sizes and/or shapes, and may be spaced at any suitable distance. For example, the electrodes 114 may have a diameter of one to five millimeters (mm). However, in other examples, the electrodes 114 and/or 114′ may have a diameter of one mm, two mm, three mm, or any other suitable diameter, dimension and shape. Example lengths for the electrodes 114 and/or 114′ include a length of one mm, three mm, five mm, or any other suitable length. Additionally, at least some of the electrodes 114 and/or 114′ may be spaced from one another by a distance of five mm, six mm, seven mm, or any other suitable distance. The electrodes 114 and/or 114′ of a single device may have different sizes with respect to each other, and the spacing of the electrodes on the device may or may not be uniform. In some cases, the electrode 114 may be a cathode with a smaller electrode surface area and the electrode 114′ may be an anode electrode with a larger electrode surface.
The communication module 102 may be electrically coupled to the electrodes 114 and/or 114′ and configured to deliver communication pulses to tissues of the patient for communicating with other devices such as sensors, programmers, other medical devices, and the like. Communication pulses, as used herein, may be any modulated signal that conveys information to another device, either by itself or in conjunction with one or more other modulated signals. In some examples, communication pulses are sub-threshold signals which convey information, but this is not required. Other devices that the communication module 102 may be configured to communicate with may be located either external or internal to the patient's body. The communication module 102 may additionally be configured to sense for communication pulses delivered by the other devices, which are located externally to the LCP 100. Irrespective of the location, the LCP 100 and the other devices may communicate with each other via the communication module 102 to accomplish one or more desired functions. Some example functions include storing communicated data, using communicated data for determining occurrences of arrhythmias, coordinating delivery of electrical stimulation therapy, and/or other functions.
The LCP 100 and the other devices may use the delivered communication pulses to communicate raw information, processed information, messages, and/or other data. Raw information may include information such as sensed electrical signals (e.g. a sensed ECG), signals gathered from coupled sensors, and the like. In some examples, the raw information may include signals that have been filtered using one or more signal processing techniques. Processed information may include any information that has been determined by the LCP 100. For example, processed information may include a determined heart rate, timings of determined heartbeats, timings of other determined events, determinations of threshold crossings, expirations of monitored time periods, and determined parameters such as activity parameters, blood-oxygen parameters, blood pressure parameters, heart sound parameters, and the like. Messages may include instructions directing another device to take action, notifications of imminent actions of the sending device, requests for reading from the receiving device or writing data to the receiving device. In some cases, the LCP 100 may communicate with an S-ICD (subcutaneous implantable cardioinverter).
In at least some examples, the communication module 102 (or the LCP 100) may further include switching circuitry to selectively connect one or more of the electrodes 114 and/or 114′ to the communication module 102 in order to select via which electrodes 114 and/or 114′ the communication module 102 delivers the communication pulses. Additionally, the communication module 102 may be configured to use one or more methods for communicating with other devices. For example, the communication module 102 may communicate via conducted signals, radiofrequency (RF) signals, optical signals, acoustic signals, inductive coupling, and/or any other signals or methods suitable for communication with an external device such as an S-ICD or a programmer.
The pulse generator module 104 of the LCP 100 may also be electrically connected to one or more of the electrodes 114 and/or 114′. The pulse generator module 104 may be configured to generate electrical stimulation pulses and deliver the electrical stimulation pulses to tissues of a patient via the electrodes 114 and/or 114′ electrodes in order to effectuate one or more electrical stimulation therapies. Electrical stimulation pulses as used herein are meant to encompass any electrical signals that may be delivered to tissue of a patient for purposes of treatment of any type of disease or abnormality. When used to treat heart diseases or abnormalities, the electrical stimulation pulses may generally be configured so as to capture the heart of the patient—cause the heart to contract in response to the delivered electrical stimulation pulse. In at least examples where the pulse generator 104 is configured to generate specific types of electrical stimulation pulses termed defibrillation/cardioversion pulses, the pulse generator module 104 may include one or more capacitor elements.
The pulse generator module 104 may include capability to modify the electrical stimulation pulses, such as by adjusting a pulse width or amplitude of the electrical stimulation pulses, in order to ensure that the delivered electrical stimulation pulses consistently capture the heart. The pulse generator module 104 may use energy stored in the energy storage module 112 to generate the electrical stimulation pulses. In at least some examples, the pulse generator module 104 (or the LCP 100) may further include switching circuitry to selectively connect one or more of the electrodes 114 and/or 114′ to the pulse generator module 104 in order to select via which electrodes 114 and/or 114′ the pulse generator 104 delivers the electrical stimulation pulses.
In some examples, the LCP 100 may include the electrical sensing module 106 and the mechanical sensing module 108. The electrical sensing module 106 may be configured to sense intrinsic cardiac electrical signals conducted from the electrodes 114 and/or 114′ to the electrical sensing module 106. For example, the electrical sensing module 106 may be electrically connected to one or more electrodes 114 and/or 114′ and the electrical sensing module 106 may be configured to receive cardiac electrical signals conducted through the electrodes 114 and/or 114′. In some examples, the cardiac electrical signals may represent local information from the chamber in which the LCP 100 is implanted. For instance, if the LCP 100 is implanted within the right atrium RA, cardiac electrical signals sensed by the LCP 100 through the electrodes 114 and/or 114′ may represent atrial cardiac electrical signals. The mechanical sensing module 108 may include, or be electrically connected to, various sensors, such as accelerometers, blood pressure sensors, heart sound sensors, blood-oxygen sensors, and/or other sensors which measure one or more physiological parameters of the heart and/or patient. The mechanical sensing module 108 may gather signals from the sensors indicative of the various physiological parameters. Both the electrical sensing module 106 and the mechanical sensing module 108 may be further connected to the processing module 110 and may provide signals representative of the sensed cardiac electrical signals and/or physiological signals to processing the module 110. Although described with respect to
The processing module 110 may be configured to control the operation of the LCP 100. For example, the processing module 110 may be configured to receive cardiac electrical signals from the electrical sensing module 106 and/or physiological signals from the mechanical sensing module 108. Based on the received signals, the processing module 110 may determine occurrences and types of arrhythmias. The processing module 110 may further receive information from the communication module 102. In some examples, the processing module 110 may additionally use such received information to determine occurrences and types of arrhythmias. However, in other examples, the LCP 100 may use the received information instead of the signals received from the electrical sensing module 106 and/or the mechanical sensing module 108—for instance if the received information is more accurate than the signals received from the electrical sensing module 106 and/or the mechanical sensing module 108 or if the electrical sensing module 106 and/or the mechanical sensing module 108 have been disabled or omitted from the LCP 100.
Based on any determined arrhythmias, the processing module 110 may then control the pulse generator module 104 to generate electrical stimulation pulses in accordance with one or more electrical stimulation therapies to treat the determined arrhythmias. For example, the processing module 110 may control the pulse generator module 104 to generate pacing pulses with varying parameters and in different sequences to effectuate one or more electrical stimulation therapies. In controlling the pulse generator module 104 to deliver bradycardia pacing therapy, the processing module 110 may control the pulse generator module 104 to deliver pacing pulses designed to capture the heart of the patient at a regular interval to prevent the heart of a patient from falling below a predetermined threshold. For ATP therapy, the processing module 110 may control the pulse generator module 104 to deliver pacing pulses at a rate faster than an intrinsic heart rate of a patient in attempt to force the heart to beat in response to the delivered pacing pulses rather than in response to intrinsic cardiac electrical signals. The processing module 110 may then control the pulse generator module 104 to reduce the rate of delivered pacing pulses down to a safe level. In CRT, the processing module 110 may control the pulse generator module 104 to deliver pacing pulses in coordination with another device (e.g. the left seed 24) to cause the heart to contract more efficiently. Additionally, in cases where the pulse generator module 104 is capable of generating defibrillation and/or cardioversion pulses for defibrillation/cardioversion therapy, the processing module 110 may control the pulse generator module 104 to generate such defibrillation and/or cardioversion pulses. In some examples, the LCO 100 may instead communicate with an S-ICD for defibrillation therapy. In other examples, the processing module 110 may control the pulse generator module 104 to generate electrical stimulation pulses to provide electrical stimulation therapies different than those described herein to treat one or more detected cardiac arrhythmias.
Aside from controlling the pulse generator module 104 to generate different types of electrical stimulation pulses and in different sequences, in some examples, the processing module 110 may also control the pulse generator module 104 to generate the various electrical stimulation pulses with varying pulse parameters. For example, each electrical stimulation pulse may have a pulse width and a pulse amplitude. The processing module 110 may control the pulse generator module 104 to generate the various electrical stimulation pulses with specific pulse widths and pulse amplitudes. For example, the processing module 110 may cause the pulse generator module 104 to adjust the pulse width and/or the pulse amplitude of electrical stimulation pulses if the electrical stimulation pulses are not effectively capturing the heart. Such control of the specific parameters of the various electrical stimulation pulses may ensure that the LCP 100 is able to provide effective delivery of electrical stimulation therapy.
In some examples, the processing module 110 may further control the communication module 102 to send information to other devices. For example, the processing module 110 may control the communication module 102 to generate one or more communication pulses for communicating with other devices of a system of devices. For instance, the processing module 110 may control the communication module 102 to generate communication pulses in particular sequences, where the specific sequences convey different data to other devices. The communication module 102 may also conduct any received communication signals to the processing module 110 for potential action by the processing module 110.
In further examples, the processing module 110 may additionally control switching circuitry by which the communication module 102 and the pulse generator module 104 deliver communication pulses and electrical stimulation pulses to tissue of the patient. As described above, both the communication module 102 and the pulse generator module 104 may include circuitry for connecting one or more electrodes 114 and/114′ to the communication module 102 and the pulse generator module 104 so those modules may deliver the communication pulses and electrical stimulation pulses to tissue of the patient. The specific combination of one or more electrodes by which the communication module 102 and the pulse generator module 104 deliver communication pulses and electrical stimulation pulses influence the reception of communication pulses and/or the effectiveness of electrical stimulation pulses. Although it was described that each of the communication module 102 and the pulse generator module 104 may include switching circuitry, in some examples the LCP 100 may have a single switching module connected to all of the communication module 102, the pulse generator module 104, and the electrodes 114 and/or 114′. In such examples, the processing module 110 may control the single switching module to connect the modules 102/104 and the electrodes 114/114′.
In still additional examples, the processing module 110 may control the pulse generator module 104 to generate the communication pulses for communicating with external devices. In such examples, the communication module 102 may not include the capability to generate communication pulses. In some even additional examples, the electrical sensing module 106 may further include the capability to sense communication pulses. In such examples, the electrical sensing module 106 may communicate any received communication pulses to the processing module 110. In such examples, the LCP 100 may not include the communication module 102, as the functions of the communication module 102 are subsumed within the pulse generator module 104 and the electrical sensing module 106. However, in such examples, the LCP 100 may not be able to simultaneously generate both communication pulses and electrical stimulation pulses.
In some examples, the processing module 110 may include a pre-programmed chip, such as a very-large-scale integration (VLSI) chip or an application specific integrated circuit (ASIC). In such embodiments, the chip may be pre-programmed with control logic in order to control the operation of the LCP 100. By using a pre-programmed chip, the processing module 110 may use less power than other programmable circuits while able to maintain basic functionality, thereby increasing the battery life of the LCP 100. In other examples, the processing module 110 may include a programmable microprocessor or the like. Such a programmable microprocessor may allow a user to adjust the control logic of the LCP 100 after manufacture, thereby allowing for greater flexibility of the LCP 100 than when using a pre-programmed chip.
The processing module 110, in additional examples, may further include a memory circuit and the processing module 110 may store information on and read information from the memory circuit. In other examples, the LCP 100 may include a separate memory circuit (not shown) that is in communication with the processing module 110, such that the processing module 110 may read and write information to and from the separate memory circuit. The memory circuit, whether part of the processing module 110 or separate from the processing module 110 may have address lengths of, for example, eight bits. However, in other examples, the memory circuit may have address lengths of sixteen, thirty-two, or sixty-four bits, or any other bit length that is suitable. Additionally, the memory circuit may be volatile memory, non-volatile memory, or a combination of both volatile memory and non-volatile memory.
The energy storage module 112 may provide a power source to the LCP 100 for its operations. In some examples, the energy storage module 112 may be a non-rechargeable lithium-based battery. In other examples, the non-rechargeable battery may be made from other suitable materials known in the art. Because the LCP 100 is an implantable device, access to the LCP 100 may be limited. In such circumstances, it is necessary to have sufficient energy capacity to deliver therapy over an extended period of treatment such as days, weeks, months, or years. In some examples, the energy storage module 112 may a rechargeable battery in order to facilitate increasing the useable lifespan of the LCP 100. In still other examples, the energy storage module 112 may be other types of energy storage devices such as capacitors.
In some cases, the LCP 200 may include a communication module 202, a pulse generator module 204, an electrical sensing module 206, a mechanical sensing module 208, a processing module 210, and a battery 218. Each of these modules may be similar to the modules 102, 104, 106, 108, and 110 of the LCP 100. Additionally, the battery 218 may be similar to the battery 112 of the LCP 100. In some cases, the LCP 200 may include leads such as leads 212. The leads 212 may include electrical wires that conduct electrical signals between the electrodes 214 and one or more of the modules located within housing 220. In some cases, the leads 212 may be connected to and extend away from the housing 220 of the LCP 200 in order to place electrodes 214 adjacent the atrial side 16 and/or the ventricle side 18 of the AV septum 12.
The mechanical sensing module 208, as with the mechanical sensing module 108, may contain or be electrically connected to one or more sensors, such as accelerometers, blood pressure sensors, heart sound sensors, blood-oxygen sensors, and/or other sensors which are configured to measure one or more mechanical/chemical parameters of the heart and/or patient. In some examples, one or more of the sensors may be located on the leads 212, but this is not required. In some examples, one or more of the sensors may be located in the housing 220.
The distal tip 318 holds the first and second electrical conduits 310, 314 in the illustrated position for deployment. In some cases, the distal tip 318 is dissolvable upon exposure to blood. In some cases, the distal tip 318 may be formed of a crystallized material such as sugar that is safe for dissolving in the blood stream. Accordingly, the first and second electrical conduits 310, 314 may be held in a delivery configuration for delivery and subsequently may move into a deployment configuration (as shown for example in
In
The cylindrical body 408 may include a proximal end 411 that is slidingly disposed within a chamber 422 that is formed within the right seed 402. It will be appreciated that the chamber 422 includes a distal end 424 that is configured to limit axial travel of the proximal end 411 of the left seed 404. Accordingly, the interaction between the proximal end 411 of the left seed 404 and the distal end 424 of the chamber 422 of the right seed 402 limits how far the left seed 404 can extend into the left ventricle LV. Once the distal tip 418 has dissolved or otherwise disappeared, the first and second electrical conduits 410 and 414 move into position against the ventricle side 18 of the AV septum 12, thereby limiting movement of the left seed 404 back towards the right atrium RA. Thus, the left seed 404 is locked in position relative to the right seed 402 and relative to the AV septum 12. In some embodiments, the left seed 404 may include a membrane 450 that may help to secure between the left seed 404 and the ventricle side 18 of the AV septum 12. In some cases, the membrane 450 may be formed of a flexible material such as silicone, and may be impregnated with a salt or other material that will cause the membrane 450 to swell upon exposure to blood. In some instances, the membrane 450 may have a folded down configuration for deployment of the left seed 404 and may subsequently revert to the expanded configuration shown in
In the example shown, the cylindrical body 508 of the left seed 504 includes a ratchet section 530 that is configured to interact with a corresponding ratchet section 532 disposed within the passage 506 formed within the right seed 502. In order to implant the LCP 500, the LCP 500 may be delivered to the right atrium RA with the left seed 504 disposed within the right seed 502 as illustrated, i.e., with the ratchet section 530 positioned outside of the right seed 502. Alternatively, the left seed 504 may be delivered to the right atrium RA and then the right seed 502 may be advanced over the left seed 504.
Once the left seed 504 has been advanced through the AV septum 12, and the distal tip 518 has dissolved or otherwise disappeared, the electrical conduits 510 and 514 may move the electrodes 512 and 516, respectively, into position against the ventricle side 18 of the AV septum 12. The left seed 504 may then be pulled back through the right seed 502 such that the ratchet section 530 engages the ratchet section 532. The ratchet sections 530 and 532 may be configured to permit the ratchet section 530 to move right to left (in the illustrated orientation), relative to the ratchet section 532 but not permit the ratchet section 530 to move left to right relative to the ratchet section 532. It will be appreciated that
In some embodiments, the left seed 504 may include a membrane 550 that may help to secure between the left seed 504 and the ventricle side 18 of the AV septum 12 and prevent blood from moving towards the right atrium RA after removal of a deployment device. In some cases, the membrane 550 may be formed of a flexible material such as silicone, and may be impregnated with a salt or other material that will cause the membrane 550 to swell upon exposure to blood. In some instances, the membrane 550 may have a folded down configuration for deployment of the left seed 504 and may subsequently revert to the expanded configuration shown in
In some cases, the cylindrical body 608 of the left seed 604 may include a threaded portion 640 that threadedly engages a corresponding threaded portion 642 formed within the passage 606. Accordingly, advancement of the left seed 604 relative to the right seed 602 may be closely controlled. Once the left seed 604 has been deployed, the distal tip 618 may dissolve or otherwise disappear, and the first electrical conduit 610 and the second electrical conduit 614 may be able to move into a deployed configuration in which the first electrode 612 and the second electrode 616 are positioned against the ventricle side 18 of the AV septum 12. The left seed 604 may then be moved backward relative to the right seed 602 in order to lock the left seed 604 in place relative to the AV septum 12 and relative to the right seed 602 by rotating the left seed 604 in an opposite direction to that used to advance the left seed 604. In some cases, the threaded portion 642 may include a vinyl bump or other structure 644 that serves to lock the left seed 604 in position and not permit undesired movement after implantation.
In some embodiments, the left seed 604 may include a membrane 650 that may help to secure between the left seed 504 and the ventricle side 18 of the AV septum 12. In some cases, the membrane 550 may be formed of a flexible material such as silicone, and may be impregnated with a salt or other material that will cause the membrane 650 to swell upon exposure to blood. In some instances, the membrane 650 may have a folded down configuration for deployment of the left seed 604 and may subsequently revert to the expanded configuration shown in
Those skilled in the art will recognize that the present disclosure may be manifested in a variety of forms other than the specific examples described and contemplated herein. For instance, as described herein, various examples include one or more modules described as performing various functions. However, other examples may include additional modules that split the described functions up over more modules than that described herein. Additionally, other examples may consolidate the described functions into fewer modules. Accordingly, departure in form and detail may be made without departing from the scope and spirit of the present disclosure as described in the appended claims.
Claims
1. An implantable medical device (IMD) configured for deployment at a patient's atrioventricular septum in order to sense and/or pace a patient's heart, the atrioventricular septum of the patient's heart having an atrial facing side defining part of the right atrium of the patient's heart and a ventricle facing side defining part of the left ventricle of the patient's heart, the IMD comprising:
- a first component configured to be positioned at least in part in the right atrium of the patient's heart proximate the atrioventricular septum once the IMD is implanted, the first component comprising: a housing; a power source disposed within the housing; and circuitry disposed within the housing and operably coupled to the power source; one or more electrodes operatively coupled to the circuitry for pacing the atrial facing side of the patient's heart; and a passageway defined by the housing;
- a second component configured to be positioned at least in part in the left ventricle of the patient's heart once the IMD is implanted, wherein the first component and the second component are configured such that the second component is translatable in its entirety relative to the first component, the second component is translatable through at least part of the passageway defined by the housing of the first component during deployment of the IMD and is configured to extend through the patient's atrioventricular septum and into the left ventricle of the patient's heart, the second component comprising: a housing; two or more electrodes for sensing and/or pacing the left ventricle of the patient's heart.
2. The IMD of claim 1, wherein the two or more electrodes of the second component are operably coupled to the circuitry of the first component.
3. The IMD of claim 1, wherein at least one of the two or more electrodes of the second component are configured to engage the ventricle facing side of the atrioventricular septum of the patient's heart once the IMD is implanted laterally where the second component is configured to extend through the patient's atrioventricular septum and into the left ventricle of the patient's heart.
4. The IMD of claim 1, wherein at least one of the two or more electrodes of the first component is configured to engage the atrial facing side of the atrioventricular septum of the patient's heart once the IMD is implanted.
5. The IMD of claim 1, wherein at least part of the second component is configured to move from a contracted state to an expanded state, wherein during implantation of the IMD, the second component is configured to pass through the atrioventricular septum in the contracted state and then move to the expanded state once in the left ventricle of the patient's heart.
6. The IMD of claim 5, wherein in the expanded state, the second component is configured to extend laterally beyond a lateral extent of where the second component would extend through the patient's atrioventricular septum and into the left ventricle of the patient's heart before engaging the left ventricle facing side of the atrioventricular septum of the patient's heart.
7. The IMD of claim 1, wherein the first component is configured to extend laterally beyond the lateral extent of the passageway defined by the housing with one or more of the electrodes of the first component configured to engage the atrial facing side of the atrioventricular septum of the patient's heart once the IMD is implanted.
8. The IMD of claim 1, wherein the second component is configured to cut a passage through the atrioventricular septum while the IMD is implanted.
9. The IMD of claim 1, wherein the second component is mechanically coupled to the first component through the passageway via a connecting member.
10. The IMD of claim 9, wherein the connecting member is part of the second component, and forms an interference fit with the first component.
11. The IMD of claim 9, wherein the connecting member is part of the first component, and forms an interference fit with the first component.
12. The IMD of claim 1, wherein the first component comprises a fixation element configured to secure the first component to the atrioventricular septum of the patient's heart.
13. The IMD of claim 1, wherein the second component comprises a fixation element configured to secure the second component to the atrioventricular septum of the patient's heart.
14. An implantable medical device (IMD) configured for deployment at a patient's atrioventricular septum, the atrioventricular septum of the patient's heart having an atrial facing side defining part of the right atrium of the patient's heart and a ventricle facing side defining part of the left ventricle of the patient's heart, the IMD comprising:
- a right seed that is configured to remain on the atrial facing side of the right atrium of the patient's heart for pacing the atrial facing side of the patient's heart, the right seed comprising: a right seed housing; a battery disposed within the right seed housing; control electronics disposed within the right seed housing; one or more electrodes operatively coupled to the control electronics for pacing the atrial facing side of the patient's heart; and a passageway defined by the right seed housing;
- a left seed that is configured to translate in its entirety relative to the right seed, the left seed translating through at least part of the passageway defined by the right seed housing during deployment of the IMD, through the patient's atrioventricular septum, and into the left ventricle of the patient's heart, the left seed comprising: a body having a first end portion, a second end portion and a connecting portion connecting the first end portion to the second end portion; at least part of the first end portion configured to be connected to the right seed once the IMD is implanted; at least part of the second end portion of the body of the left seed configured to extend into the left ventricle of the patient's heart once the IMD is implanted; the connecting portion configured to extend through a passage that passes through the atrioventricular septum; and the second end portion of the body of the left seed including one or more electrodes for sensing and/or pacing the left ventricle of the patient's heart, the second end portion extending laterally beyond a lateral extent of the connecting portion such that at least one of the one or more electrodes of the second end portion is configured to engage the ventricle facing side of the atrioventricular septum of the patient's heart laterally beyond the lateral extent of the connecting portion once the IMD is implanted.
15. The IMD of claim 14, wherein the one or more electrodes of the second end portion of the left seed are operatively connected to the control electronics of the right seed through the connecting portion of the left seed.
16. The IMD of claim 14, wherein at least part of the second end portion is configured to move from a contracted state to an expanded state during deployment of the IMD.
17. A method of deploying a leadless pacing and sensing assembly proximate a patient's atrioventricular septum, the leadless pacing and sensing assembly including a right atrial leadless cardiac pacemaker (LCP) and a left ventricular leadless cardiac pacemaker (LCP), the method comprising:
- advancing a delivery catheter through the patient's vasculature until a distal end of the delivery catheter is proximate an atrial side of the atrioventricular septum, the right atrial LCP disposed within a distal region of the delivery catheter;
- advancing a deployment device through a passageway extending through the right atrial LCP and through the atrioventricular septum, the left ventricular LCP secured to the deployment device such that the left ventricular LCP extends through the right atrial LCP and is disposed proximate a ventricular side of the atrioventricular septum, the left ventricular LCP including one or more electrodes configured to extend laterally past a lateral extent of the passageway and to engage the ventricle facing side of the atrioventricular septum of the patient's heart;
- securing the left ventricular LCP to the right atrial LCP; and
- withdrawing the deployment device.
18. The method of claim 17, further comprising withdrawing the delivery catheter.
3835864 | September 1974 | Rasor et al. |
3943936 | March 16, 1976 | Rasor et al. |
4142530 | March 6, 1979 | Wittkampf |
4151513 | April 24, 1979 | Menken et al. |
4157720 | June 12, 1979 | Greatbatch |
RE30366 | August 12, 1980 | Rasor et al. |
4243045 | January 6, 1981 | Maas |
4250884 | February 17, 1981 | Hartlaub et al. |
4256115 | March 17, 1981 | Bilitch |
4263919 | April 28, 1981 | Levin |
4310000 | January 12, 1982 | Lindemans |
4312354 | January 26, 1982 | Walters |
4323081 | April 6, 1982 | Wiebusch |
4357946 | November 9, 1982 | Dutcher et al. |
4365639 | December 28, 1982 | Goldreyer |
4440173 | April 3, 1984 | Hudziak et al. |
4476868 | October 16, 1984 | Thompson |
4522208 | June 11, 1985 | Buffet |
4537200 | August 27, 1985 | Widrow |
4556063 | December 3, 1985 | Thompson et al. |
4562841 | January 7, 1986 | Brockway et al. |
4593702 | June 10, 1986 | Kepski et al. |
4593955 | June 10, 1986 | Leiber |
4630611 | December 23, 1986 | King |
4635639 | January 13, 1987 | Hakala et al. |
4674508 | June 23, 1987 | DeCote |
4712554 | December 15, 1987 | Garson |
4729376 | March 8, 1988 | DeCote |
4754753 | July 5, 1988 | King |
4759366 | July 26, 1988 | Callaghan |
4776338 | October 11, 1988 | Lekholm et al. |
4787389 | November 29, 1988 | Tarjan |
4793353 | December 27, 1988 | Borkan |
4819662 | April 11, 1989 | Heil et al. |
4858610 | August 22, 1989 | Callaghan et al. |
4886064 | December 12, 1989 | Strandberg |
4887609 | December 19, 1989 | Cole, Jr. |
4928688 | May 29, 1990 | Mower |
4967746 | November 6, 1990 | Vandegriff |
4987897 | January 29, 1991 | Funke |
4989602 | February 5, 1991 | Sholder et al. |
5012806 | May 7, 1991 | De Bellis |
5036849 | August 6, 1991 | Hauck et al. |
5040534 | August 20, 1991 | Mann et al. |
5058581 | October 22, 1991 | Silvian |
5078134 | January 7, 1992 | Heilman et al. |
5109845 | May 5, 1992 | Yuuchi et al. |
5113859 | May 19, 1992 | Funke |
5113869 | May 19, 1992 | Nappholz et al. |
5117824 | June 2, 1992 | Keimel et al. |
5127401 | July 7, 1992 | Grevious et al. |
5133353 | July 28, 1992 | Hauser |
5144950 | September 8, 1992 | Stoop et al. |
5170784 | December 15, 1992 | Ramon et al. |
5179945 | January 19, 1993 | Van Hofwegen et al. |
5193539 | March 16, 1993 | Schulman et al. |
5193540 | March 16, 1993 | Schulman et al. |
5241961 | September 7, 1993 | Henry |
5243977 | September 14, 1993 | Trabucco et al. |
5259387 | November 9, 1993 | dePinto |
5269326 | December 14, 1993 | Verrier |
5284136 | February 8, 1994 | Hauck et al. |
5300107 | April 5, 1994 | Stokes et al. |
5301677 | April 12, 1994 | Hsung |
5305760 | April 26, 1994 | McKown et al. |
5312439 | May 17, 1994 | Loeb |
5313953 | May 24, 1994 | Yomtov et al. |
5314459 | May 24, 1994 | Swanson et al. |
5318597 | June 7, 1994 | Hauck et al. |
5324316 | June 28, 1994 | Schulman et al. |
5331966 | July 26, 1994 | Bennett et al. |
5334222 | August 2, 1994 | Salo et al. |
5342408 | August 30, 1994 | Decoriolis et al. |
5370667 | December 6, 1994 | Alt |
5372606 | December 13, 1994 | Lang et al. |
5376106 | December 27, 1994 | Stahmann et al. |
5383915 | January 24, 1995 | Adams |
5388578 | February 14, 1995 | Yomtov et al. |
5404877 | April 11, 1995 | Nolan et al. |
5405367 | April 11, 1995 | Schulman et al. |
5411031 | May 2, 1995 | Yomtov |
5411525 | May 2, 1995 | Swanson et al. |
5411535 | May 2, 1995 | Fujii et al. |
5456691 | October 10, 1995 | Snell |
5458622 | October 17, 1995 | Alt |
5466246 | November 14, 1995 | Silvian |
5468254 | November 21, 1995 | Hahn et al. |
5472453 | December 5, 1995 | Alt |
5522866 | June 4, 1996 | Fernald |
5540727 | July 30, 1996 | Tockman et al. |
5545186 | August 13, 1996 | Olson et al. |
5545202 | August 13, 1996 | Dahl et al. |
5571146 | November 5, 1996 | Jones et al. |
5591214 | January 7, 1997 | Lu |
5620466 | April 15, 1997 | Haefner et al. |
5634938 | June 3, 1997 | Swanson et al. |
5649968 | July 22, 1997 | Alt et al. |
5662688 | September 2, 1997 | Haefner et al. |
5674259 | October 7, 1997 | Gray |
5683426 | November 4, 1997 | Greenhut et al. |
5683432 | November 4, 1997 | Goedeke et al. |
5706823 | January 13, 1998 | Wodlinger |
5709215 | January 20, 1998 | Perttu et al. |
5720770 | February 24, 1998 | Nappholz et al. |
5728154 | March 17, 1998 | Crossett et al. |
5741314 | April 21, 1998 | Daly et al. |
5741315 | April 21, 1998 | Lee et al. |
5752976 | May 19, 1998 | Duffin et al. |
5752977 | May 19, 1998 | Grevious et al. |
5755736 | May 26, 1998 | Gillberg et al. |
5759199 | June 2, 1998 | Snell et al. |
5774501 | June 30, 1998 | Halpern et al. |
5792195 | August 11, 1998 | Carlson et al. |
5792202 | August 11, 1998 | Rueter |
5792203 | August 11, 1998 | Schroeppel |
5792205 | August 11, 1998 | Alt et al. |
5792208 | August 11, 1998 | Gray |
5814089 | September 29, 1998 | Stokes et al. |
5827216 | October 27, 1998 | Igo et al. |
5836985 | November 17, 1998 | Goyal et al. |
5836987 | November 17, 1998 | Baumann et al. |
5842977 | December 1, 1998 | Lesho et al. |
5855593 | January 5, 1999 | Olson et al. |
5873894 | February 23, 1999 | Vandegriff et al. |
5891184 | April 6, 1999 | Lee et al. |
5897586 | April 27, 1999 | Molina |
5899876 | May 4, 1999 | Flower |
5899928 | May 4, 1999 | Sholder et al. |
5919214 | July 6, 1999 | Ciciarelli et al. |
5935078 | August 10, 1999 | Feierbach |
5941906 | August 24, 1999 | Barreras et al. |
5944744 | August 31, 1999 | Paul et al. |
5954757 | September 21, 1999 | Gray |
5978713 | November 2, 1999 | Prutchi et al. |
5991660 | November 23, 1999 | Goyal |
5991661 | November 23, 1999 | Park et al. |
5999848 | December 7, 1999 | Gord et al. |
5999857 | December 7, 1999 | Weijand et al. |
6016445 | January 18, 2000 | Baura |
6026320 | February 15, 2000 | Carlson et al. |
6029085 | February 22, 2000 | Olson et al. |
6041250 | March 21, 2000 | dePinto |
6044298 | March 28, 2000 | Salo et al. |
6044300 | March 28, 2000 | Gray |
6055454 | April 25, 2000 | Heemels |
6073050 | June 6, 2000 | Griffith |
6076016 | June 13, 2000 | Feierbach |
6077236 | June 20, 2000 | Cunningham |
6080187 | June 27, 2000 | Alt et al. |
6083248 | July 4, 2000 | Thompson |
6106551 | August 22, 2000 | Crossett et al. |
6115636 | September 5, 2000 | Ryan |
6128526 | October 3, 2000 | Stadler et al. |
6141581 | October 31, 2000 | Olson et al. |
6141588 | October 31, 2000 | Cox et al. |
6141592 | October 31, 2000 | Pauly |
6144879 | November 7, 2000 | Gray |
6162195 | December 19, 2000 | Igo et al. |
6164284 | December 26, 2000 | Schulman et al. |
6167310 | December 26, 2000 | Grevious |
6201993 | March 13, 2001 | Kruse et al. |
6208894 | March 27, 2001 | Schulman et al. |
6211799 | April 3, 2001 | Post et al. |
6221011 | April 24, 2001 | Bardy |
6240316 | May 29, 2001 | Richmond et al. |
6240317 | May 29, 2001 | Villaseca et al. |
6256534 | July 3, 2001 | Dahl |
6259947 | July 10, 2001 | Olson et al. |
6266558 | July 24, 2001 | Gozani et al. |
6266567 | July 24, 2001 | Ishikawa et al. |
6270457 | August 7, 2001 | Bardy |
6272377 | August 7, 2001 | Sweeney et al. |
6273856 | August 14, 2001 | Sun et al. |
6277072 | August 21, 2001 | Bardy |
6280380 | August 28, 2001 | Bardy |
6285907 | September 4, 2001 | Kramer et al. |
6292698 | September 18, 2001 | Duffin et al. |
6295473 | September 25, 2001 | Rosar |
6297943 | October 2, 2001 | Carson |
6298271 | October 2, 2001 | Weijand |
6307751 | October 23, 2001 | Bodony et al. |
6312378 | November 6, 2001 | Bardy |
6315721 | November 13, 2001 | Schulman et al. |
6336903 | January 8, 2002 | Bardy |
6345202 | February 5, 2002 | Richmond et al. |
6351667 | February 26, 2002 | Godie |
6351669 | February 26, 2002 | Hartley et al. |
6353759 | March 5, 2002 | Hartley et al. |
6358203 | March 19, 2002 | Bardy |
6361780 | March 26, 2002 | Ley et al. |
6368284 | April 9, 2002 | Bardy |
6371922 | April 16, 2002 | Baumann et al. |
6398728 | June 4, 2002 | Bardy |
6400982 | June 4, 2002 | Sweeney et al. |
6400990 | June 4, 2002 | Silvian |
6408208 | June 18, 2002 | Sun |
6409674 | June 25, 2002 | Brockway et al. |
6411848 | June 25, 2002 | Kramer et al. |
6424865 | July 23, 2002 | Ding |
6434429 | August 13, 2002 | Kraus et al. |
6438410 | August 20, 2002 | Hsu et al. |
6438417 | August 20, 2002 | Rockwell et al. |
6438421 | August 20, 2002 | Stahmann et al. |
6440066 | August 27, 2002 | Bardy |
6441747 | August 27, 2002 | Khair et al. |
6442426 | August 27, 2002 | Kroll |
6442432 | August 27, 2002 | Lee |
6443891 | September 3, 2002 | Grevious |
6445953 | September 3, 2002 | Bulkes et al. |
6453200 | September 17, 2002 | Koslar |
6459929 | October 1, 2002 | Hopper et al. |
6470215 | October 22, 2002 | Kraus et al. |
6471645 | October 29, 2002 | Warkentin et al. |
6480745 | November 12, 2002 | Nelson et al. |
6487443 | November 26, 2002 | Olson et al. |
6490487 | December 3, 2002 | Kraus et al. |
6498951 | December 24, 2002 | Larson et al. |
6507755 | January 14, 2003 | Gozani et al. |
6507759 | January 14, 2003 | Prutchi et al. |
6512940 | January 28, 2003 | Brabec et al. |
6522915 | February 18, 2003 | Ceballos et al. |
6526311 | February 25, 2003 | Begemann |
6539253 | March 25, 2003 | Thompson et al. |
6542775 | April 1, 2003 | Ding et al. |
6553258 | April 22, 2003 | Stahmann et al. |
6561975 | May 13, 2003 | Pool et al. |
6564807 | May 20, 2003 | Schulman et al. |
6574506 | June 3, 2003 | Kramer et al. |
6584351 | June 24, 2003 | Ekwall |
6584352 | June 24, 2003 | Combs et al. |
6597948 | July 22, 2003 | Rockwell et al. |
6597951 | July 22, 2003 | Kramer et al. |
6622046 | September 16, 2003 | Fraley et al. |
6628985 | September 30, 2003 | Sweeney et al. |
6647292 | November 11, 2003 | Bardy et al. |
6666844 | December 23, 2003 | Igo et al. |
6689117 | February 10, 2004 | Sweeney et al. |
6690959 | February 10, 2004 | Thompson |
6694189 | February 17, 2004 | Begemann |
6704602 | March 9, 2004 | Berg et al. |
6718212 | April 6, 2004 | Parry et al. |
6721597 | April 13, 2004 | Bardy et al. |
6738670 | May 18, 2004 | Almendinger et al. |
6746797 | June 8, 2004 | Benson et al. |
6749566 | June 15, 2004 | Russ |
6758810 | July 6, 2004 | Lebel et al. |
6763269 | July 13, 2004 | Cox |
6778860 | August 17, 2004 | Ostroff et al. |
6788971 | September 7, 2004 | Sloman et al. |
6788974 | September 7, 2004 | Bardy et al. |
6804558 | October 12, 2004 | Haller et al. |
6807442 | October 19, 2004 | Myklebust et al. |
6847844 | January 25, 2005 | Sun et al. |
6871095 | March 22, 2005 | Stahmann et al. |
6878112 | April 12, 2005 | Linberg et al. |
6885889 | April 26, 2005 | Chinchoy |
6892094 | May 10, 2005 | Ousdigian et al. |
6897788 | May 24, 2005 | Khair et al. |
6904315 | June 7, 2005 | Panken et al. |
6922592 | July 26, 2005 | Thompson et al. |
6931282 | August 16, 2005 | Esler |
6934585 | August 23, 2005 | Schloss et al. |
6957107 | October 18, 2005 | Rogers et al. |
6978176 | December 20, 2005 | Lattouf |
6985773 | January 10, 2006 | Von Arx et al. |
6990375 | January 24, 2006 | Kloss et al. |
7001366 | February 21, 2006 | Ballard |
7003350 | February 21, 2006 | Denker et al. |
7006864 | February 28, 2006 | Echt et al. |
7013178 | March 14, 2006 | Reinke et al. |
7027871 | April 11, 2006 | Burnes et al. |
7050849 | May 23, 2006 | Echt et al. |
7060031 | June 13, 2006 | Webb et al. |
7063693 | June 20, 2006 | Guenst |
7082336 | July 25, 2006 | Ransbury et al. |
7085606 | August 1, 2006 | Flach et al. |
7092758 | August 15, 2006 | Sun et al. |
7110824 | September 19, 2006 | Amundson et al. |
7120504 | October 10, 2006 | Osypka |
7130681 | October 31, 2006 | Gebhardt et al. |
7139613 | November 21, 2006 | Reinke et al. |
7142912 | November 28, 2006 | Wagner et al. |
7146225 | December 5, 2006 | Guenst et al. |
7146226 | December 5, 2006 | Lau et al. |
7149581 | December 12, 2006 | Goedeke |
7149588 | December 12, 2006 | Lau et al. |
7158839 | January 2, 2007 | Lau |
7162307 | January 9, 2007 | Patrias |
7164952 | January 16, 2007 | Lau et al. |
7177700 | February 13, 2007 | Cox |
7181505 | February 20, 2007 | Haller et al. |
7184830 | February 27, 2007 | Echt et al. |
7186214 | March 6, 2007 | Ness |
7191015 | March 13, 2007 | Lamson et al. |
7200437 | April 3, 2007 | Nabutovsky et al. |
7200439 | April 3, 2007 | Zdeblick et al. |
7206423 | April 17, 2007 | Feng et al. |
7209785 | April 24, 2007 | Kim et al. |
7209790 | April 24, 2007 | Thompson et al. |
7211884 | May 1, 2007 | Davis et al. |
7212871 | May 1, 2007 | Morgan |
7226440 | June 5, 2007 | Gelfand et al. |
7228183 | June 5, 2007 | Sun et al. |
7236821 | June 26, 2007 | Cates et al. |
7236829 | June 26, 2007 | Farazi et al. |
7254448 | August 7, 2007 | Almendinger et al. |
7260436 | August 21, 2007 | Kilgore et al. |
7270669 | September 18, 2007 | Sra |
7272448 | September 18, 2007 | Morgan et al. |
7277755 | October 2, 2007 | Falkenberg et al. |
7280872 | October 9, 2007 | Mosesov et al. |
7288096 | October 30, 2007 | Chin |
7289847 | October 30, 2007 | Gill et al. |
7289852 | October 30, 2007 | Helfinstine et al. |
7289853 | October 30, 2007 | Campbell et al. |
7289855 | October 30, 2007 | Nghiem et al. |
7302294 | November 27, 2007 | Kamath et al. |
7305266 | December 4, 2007 | Kroll |
7310556 | December 18, 2007 | Bulkes |
7319905 | January 15, 2008 | Morgan et al. |
7321798 | January 22, 2008 | Muhlenberg et al. |
7333853 | February 19, 2008 | Mazar et al. |
7336994 | February 26, 2008 | Hettrick et al. |
7347819 | March 25, 2008 | Lebel et al. |
7366572 | April 29, 2008 | Heruth et al. |
7373207 | May 13, 2008 | Lattouf |
7384403 | June 10, 2008 | Sherman |
7386342 | June 10, 2008 | Falkenberg et al. |
7392090 | June 24, 2008 | Sweeney et al. |
7406105 | July 29, 2008 | DelMain et al. |
7406349 | July 29, 2008 | Seeberger et al. |
7410497 | August 12, 2008 | Hastings et al. |
7425200 | September 16, 2008 | Brockway et al. |
7433739 | October 7, 2008 | Salys et al. |
7448999 | November 11, 2008 | Karicherla |
7496409 | February 24, 2009 | Greenhut et al. |
7496410 | February 24, 2009 | Heil |
7502652 | March 10, 2009 | Gaunt et al. |
7512448 | March 31, 2009 | Malick et al. |
7515969 | April 7, 2009 | Tockman et al. |
7526342 | April 28, 2009 | Chin et al. |
7529589 | May 5, 2009 | Williams et al. |
7532933 | May 12, 2009 | Hastings et al. |
7536222 | May 19, 2009 | Bardy et al. |
7536224 | May 19, 2009 | Ritscher et al. |
7539541 | May 26, 2009 | Quiles et al. |
7544197 | June 9, 2009 | Kelsch et al. |
7558631 | July 7, 2009 | Cowan et al. |
7565195 | July 21, 2009 | Kroll et al. |
7584002 | September 1, 2009 | Burnes et al. |
7590455 | September 15, 2009 | Heruth et al. |
7606621 | October 20, 2009 | Brisken et al. |
7610088 | October 27, 2009 | Chinchoy |
7610092 | October 27, 2009 | Cowan et al. |
7610099 | October 27, 2009 | Almendinger et al. |
7610104 | October 27, 2009 | Kaplan et al. |
7616991 | November 10, 2009 | Mann et al. |
7617001 | November 10, 2009 | Penner et al. |
7617007 | November 10, 2009 | Williams et al. |
7630767 | December 8, 2009 | Poore et al. |
7634313 | December 15, 2009 | Kroll et al. |
7637867 | December 29, 2009 | Zdeblick |
7640060 | December 29, 2009 | Zdeblick |
7647109 | January 12, 2010 | Hastings et al. |
7650186 | January 19, 2010 | Hastings et al. |
7657311 | February 2, 2010 | Bardy et al. |
7668596 | February 23, 2010 | Von Arx et al. |
7682316 | March 23, 2010 | Anderson et al. |
7691047 | April 6, 2010 | Ferrari |
7702392 | April 20, 2010 | Echt et al. |
7713194 | May 11, 2010 | Zdeblick |
7713195 | May 11, 2010 | Zdeblick |
7729783 | June 1, 2010 | Michels et al. |
7734333 | June 8, 2010 | Ghanem et al. |
7734343 | June 8, 2010 | Ransbury et al. |
7738958 | June 15, 2010 | Zdeblick et al. |
7738964 | June 15, 2010 | Von Arx et al. |
7742812 | June 22, 2010 | Ghanem et al. |
7742816 | June 22, 2010 | Masoud et al. |
7742822 | June 22, 2010 | Masoud et al. |
7743151 | June 22, 2010 | Vallapureddy et al. |
7747335 | June 29, 2010 | Williams |
7751881 | July 6, 2010 | Cowan et al. |
7758521 | July 20, 2010 | Morris et al. |
7761150 | July 20, 2010 | Ghanem et al. |
7761164 | July 20, 2010 | Verhoef et al. |
7765001 | July 27, 2010 | Echt et al. |
7769452 | August 3, 2010 | Ghanem et al. |
7783362 | August 24, 2010 | Whitehurst et al. |
7792588 | September 7, 2010 | Harding |
7797059 | September 14, 2010 | Bornzin et al. |
7801596 | September 21, 2010 | Fischell et al. |
7809438 | October 5, 2010 | Echt et al. |
7840281 | November 23, 2010 | Kveen et al. |
7844331 | November 30, 2010 | Li et al. |
7844348 | November 30, 2010 | Swoyer et al. |
7846088 | December 7, 2010 | Ness |
7848815 | December 7, 2010 | Brisken et al. |
7848823 | December 7, 2010 | Drasler et al. |
7860455 | December 28, 2010 | Fukumoto et al. |
7871433 | January 18, 2011 | Lattouf |
7877136 | January 25, 2011 | Moffitt et al. |
7877142 | January 25, 2011 | Moaddeb et al. |
7881786 | February 1, 2011 | Jackson |
7881798 | February 1, 2011 | Miesel et al. |
7881810 | February 1, 2011 | Chitre et al. |
7890173 | February 15, 2011 | Brisken et al. |
7890181 | February 15, 2011 | Denzene et al. |
7890192 | February 15, 2011 | Kelsch et al. |
7894885 | February 22, 2011 | Bartal et al. |
7894894 | February 22, 2011 | Stadler et al. |
7894907 | February 22, 2011 | Cowan et al. |
7894910 | February 22, 2011 | Cowan et al. |
7894915 | February 22, 2011 | Chitre et al. |
7899537 | March 1, 2011 | Kroll et al. |
7899541 | March 1, 2011 | Cowan et al. |
7899542 | March 1, 2011 | Cowan et al. |
7899554 | March 1, 2011 | Williams et al. |
7901360 | March 8, 2011 | Yang et al. |
7904170 | March 8, 2011 | Harding |
7907993 | March 15, 2011 | Ghanem et al. |
7920928 | April 5, 2011 | Yang et al. |
7925343 | April 12, 2011 | Min et al. |
7930022 | April 19, 2011 | Zhang et al. |
7930040 | April 19, 2011 | Kelsch et al. |
7937135 | May 3, 2011 | Ghanem et al. |
7937148 | May 3, 2011 | Jacobson |
7937161 | May 3, 2011 | Hastings et al. |
7941214 | May 10, 2011 | Kleckner et al. |
7945333 | May 17, 2011 | Jacobson |
7946997 | May 24, 2011 | Hübinette |
7949404 | May 24, 2011 | Hill |
7949405 | May 24, 2011 | Feher |
7953486 | May 31, 2011 | Daum et al. |
7953493 | May 31, 2011 | Fowler et al. |
7962202 | June 14, 2011 | Bhunia |
7974702 | July 5, 2011 | Fain et al. |
7979136 | July 12, 2011 | Young et al. |
7983753 | July 19, 2011 | Severin |
7991467 | August 2, 2011 | Markowitz et al. |
7991471 | August 2, 2011 | Ghanem et al. |
7996087 | August 9, 2011 | Cowan et al. |
8000791 | August 16, 2011 | Sunagawa et al. |
8000807 | August 16, 2011 | Morris et al. |
8001975 | August 23, 2011 | DiSilvestro et al. |
8002700 | August 23, 2011 | Ferek-Petric et al. |
8010209 | August 30, 2011 | Jacobson |
8019419 | September 13, 2011 | Panescu et al. |
8019434 | September 13, 2011 | Quiles et al. |
8027727 | September 27, 2011 | Freeberg |
8027729 | September 27, 2011 | Sunagawa et al. |
8032219 | October 4, 2011 | Neumann et al. |
8036743 | October 11, 2011 | Savage et al. |
8046079 | October 25, 2011 | Bange et al. |
8046080 | October 25, 2011 | Von Arx et al. |
8050297 | November 1, 2011 | Delmain et al. |
8050759 | November 1, 2011 | Stegemann et al. |
8050774 | November 1, 2011 | Kveen et al. |
8055345 | November 8, 2011 | Li et al. |
8055350 | November 8, 2011 | Roberts |
8060212 | November 15, 2011 | Rios et al. |
8065018 | November 22, 2011 | Haubrich et al. |
8073542 | December 6, 2011 | Doerr |
8078278 | December 13, 2011 | Penner |
8078283 | December 13, 2011 | Cowan et al. |
8095123 | January 10, 2012 | Gray |
8102789 | January 24, 2012 | Rosar et al. |
8103359 | January 24, 2012 | Reddy |
8103361 | January 24, 2012 | Moser |
8112148 | February 7, 2012 | Giftakis et al. |
8114021 | February 14, 2012 | Robertson et al. |
8121680 | February 21, 2012 | Falkenberg et al. |
8123684 | February 28, 2012 | Zdeblick |
8126545 | February 28, 2012 | Flach et al. |
8131334 | March 6, 2012 | Lu et al. |
8140161 | March 20, 2012 | Willerton et al. |
8150521 | April 3, 2012 | Crowley et al. |
8160672 | April 17, 2012 | Kim et al. |
8160702 | April 17, 2012 | Mann et al. |
8160704 | April 17, 2012 | Freeberg |
8165694 | April 24, 2012 | Carbanaru et al. |
8175715 | May 8, 2012 | Cox |
8180451 | May 15, 2012 | Hickman et al. |
8185213 | May 22, 2012 | Kveen et al. |
8187161 | May 29, 2012 | Li et al. |
8195293 | June 5, 2012 | Limousin et al. |
8204595 | June 19, 2012 | Pianca et al. |
8204605 | June 19, 2012 | Hastings et al. |
8209014 | June 26, 2012 | Doerr |
8214043 | July 3, 2012 | Matos |
8224244 | July 17, 2012 | Kim et al. |
8229556 | July 24, 2012 | Li |
8233985 | July 31, 2012 | Bulkes et al. |
8265748 | September 11, 2012 | Liu et al. |
8265757 | September 11, 2012 | Mass et al. |
8262578 | September 11, 2012 | Bharmi et al. |
8280521 | October 2, 2012 | Haubrich et al. |
8285387 | October 9, 2012 | Utsi et al. |
8290598 | October 16, 2012 | Boon et al. |
8290600 | October 16, 2012 | Hastings et al. |
8295939 | October 23, 2012 | Jacobson |
8301254 | October 30, 2012 | Mosesov et al. |
8315701 | November 20, 2012 | Cowan et al. |
8315708 | November 20, 2012 | Berthelsdorf et al. |
8321021 | November 27, 2012 | Kisker et al. |
8321036 | November 27, 2012 | Brockway et al. |
8332036 | December 11, 2012 | Hastings et al. |
8335563 | December 18, 2012 | Stessman |
8335568 | December 18, 2012 | Heruth et al. |
8340750 | December 25, 2012 | Prakash et al. |
8340780 | December 25, 2012 | Hastings et al. |
8352025 | January 8, 2013 | Jacobson |
8352028 | January 8, 2013 | Wenger |
8352038 | January 8, 2013 | Mao et al. |
8359098 | January 22, 2013 | Lund et al. |
8364261 | January 29, 2013 | Stubbs et al. |
8364276 | January 29, 2013 | Willis |
8369959 | February 5, 2013 | Meskens |
8369962 | February 5, 2013 | Abrahamson |
8380320 | February 19, 2013 | Spital |
8386051 | February 26, 2013 | Rys |
8391981 | March 5, 2013 | Mosesov |
8391990 | March 5, 2013 | Smith et al. |
8406874 | March 26, 2013 | Liu et al. |
8406879 | March 26, 2013 | Shuros et al. |
8406886 | March 26, 2013 | Gaunt et al. |
8412352 | April 2, 2013 | Griswold et al. |
8417340 | April 9, 2013 | Goossen |
8417341 | April 9, 2013 | Freeberg |
8423149 | April 16, 2013 | Hennig |
8428722 | April 23, 2013 | Verhoef et al. |
8433402 | April 30, 2013 | Ruben et al. |
8433409 | April 30, 2013 | Johnson et al. |
8433420 | April 30, 2013 | Bange et al. |
8447412 | May 21, 2013 | Dal Molin et al. |
8452413 | May 28, 2013 | Young et al. |
8457740 | June 4, 2013 | Osche |
8457742 | June 4, 2013 | Jacobson |
8457744 | June 4, 2013 | Janzig et al. |
8457761 | June 4, 2013 | Wariar |
8478407 | July 2, 2013 | Demmer et al. |
8478408 | July 2, 2013 | Hastings et al. |
8478431 | July 2, 2013 | Griswold et al. |
8494632 | July 23, 2013 | Sun et al. |
8504156 | August 6, 2013 | Bonner et al. |
8509910 | August 13, 2013 | Sowder et al. |
8515559 | August 20, 2013 | Roberts et al. |
8525340 | September 3, 2013 | Eckhardt et al. |
8527068 | September 3, 2013 | Ostroff |
8532790 | September 10, 2013 | Griswold |
8538526 | September 17, 2013 | Stahmann et al. |
8541131 | September 24, 2013 | Lund et al. |
8543205 | September 24, 2013 | Ostroff |
8547248 | October 1, 2013 | Zdeblick et al. |
8548605 | October 1, 2013 | Ollivier |
8554333 | October 8, 2013 | Wu et al. |
8565882 | October 22, 2013 | Matos |
8565897 | October 22, 2013 | Regnier et al. |
8571678 | October 29, 2013 | Wang |
8577327 | November 5, 2013 | Makdissi et al. |
8588926 | November 19, 2013 | Moore et al. |
8612002 | December 17, 2013 | Faltys et al. |
8615310 | December 24, 2013 | Khairkhahan et al. |
8626280 | January 7, 2014 | Allavatam et al. |
8626294 | January 7, 2014 | Sheldon et al. |
8634908 | January 21, 2014 | Cowan |
8634912 | January 21, 2014 | Bornzin et al. |
8634919 | January 21, 2014 | Hou et al. |
8639335 | January 28, 2014 | Peichel et al. |
8644934 | February 4, 2014 | Hastings et al. |
8649859 | February 11, 2014 | Smith et al. |
8670842 | March 11, 2014 | Bornzin et al. |
8676319 | March 18, 2014 | Knoll |
8676335 | March 18, 2014 | Katoozi et al. |
8700173 | April 15, 2014 | Edlund |
8700181 | April 15, 2014 | Bornzin et al. |
8705599 | April 22, 2014 | dal Molin et al. |
8718766 | May 6, 2014 | Wahlberg |
8718773 | May 6, 2014 | Willis et al. |
8725260 | May 13, 2014 | Shuros et al. |
8738133 | May 27, 2014 | Shuros et al. |
8738147 | May 27, 2014 | Hastings et al. |
8744555 | June 3, 2014 | Allavatam et al. |
8744572 | June 3, 2014 | Greenhut et al. |
8747314 | June 10, 2014 | Stahmann et al. |
8755884 | June 17, 2014 | Demmer et al. |
8758365 | June 24, 2014 | Bonner et al. |
8768483 | July 1, 2014 | Schmitt et al. |
8774572 | July 8, 2014 | Hamamoto |
8781605 | July 15, 2014 | Bornzin et al. |
8788035 | July 22, 2014 | Jacobson |
8788053 | July 22, 2014 | Jacobson |
8798740 | August 5, 2014 | Samade et al. |
8798745 | August 5, 2014 | Jacobson |
8798762 | August 5, 2014 | Fain et al. |
8798770 | August 5, 2014 | Reddy |
8805505 | August 12, 2014 | Roberts |
8805528 | August 12, 2014 | Corndort |
8812109 | August 19, 2014 | Blomqvist et al. |
8818504 | August 26, 2014 | Bodner et al. |
8827913 | September 9, 2014 | Havel et al. |
8831747 | September 9, 2014 | Min et al. |
8855789 | October 7, 2014 | Jacobson |
8868186 | October 21, 2014 | Kroll |
8886339 | November 11, 2014 | Faltys et al. |
8903473 | December 2, 2014 | Rogers et al. |
8903500 | December 2, 2014 | Smith et al. |
8903513 | December 2, 2014 | Ollivier |
8909336 | December 9, 2014 | Navarro-Paredes et al. |
8914131 | December 16, 2014 | Bornzin et al. |
8923795 | December 30, 2014 | Makdissi et al. |
8923963 | December 30, 2014 | Bonner et al. |
8938300 | January 20, 2015 | Rosero |
8942806 | January 27, 2015 | Sheldon et al. |
8958892 | February 17, 2015 | Khairkhahan et al. |
8977358 | March 10, 2015 | Ewert et al. |
8989873 | March 24, 2015 | Locsin |
8996109 | March 31, 2015 | Karst et al. |
9002467 | April 7, 2015 | Smith et al. |
9008776 | April 14, 2015 | Cowan et al. |
9008777 | April 14, 2015 | Dianaty et al. |
9014818 | April 21, 2015 | Deterre et al. |
9017341 | April 28, 2015 | Bornzin et al. |
9020611 | April 28, 2015 | Khairkhahan et al. |
9037262 | May 19, 2015 | Regnier et al. |
9042984 | May 26, 2015 | Demmer et al. |
9072911 | July 7, 2015 | Hastings et al. |
9072913 | July 7, 2015 | Jacobson |
9155882 | October 13, 2015 | Grubac et al. |
9168372 | October 27, 2015 | Fain |
9168380 | October 27, 2015 | Greenhut et al. |
9168383 | October 27, 2015 | Jacobson et al. |
9180285 | November 10, 2015 | Moore et al. |
9192774 | November 24, 2015 | Jacobson |
9205225 | December 8, 2015 | Khairkhahan et al. |
9216285 | December 22, 2015 | Boling et al. |
9216293 | December 22, 2015 | Berthiaume et al. |
9216298 | December 22, 2015 | Jacobson |
9227077 | January 5, 2016 | Jacobson |
9238145 | January 19, 2016 | Wenzel et al. |
9242102 | January 26, 2016 | Khairkhahan et al. |
9242113 | January 26, 2016 | Smith et al. |
9248300 | February 2, 2016 | Rys et al. |
9265436 | February 23, 2016 | Min et al. |
9265962 | February 23, 2016 | Dianaty et al. |
9272155 | March 1, 2016 | Ostroff |
9278218 | March 8, 2016 | Karst et al. |
9278229 | March 8, 2016 | Reinke et al. |
9283381 | March 15, 2016 | Grubac et al. |
9283382 | March 15, 2016 | Berthiaume et al. |
9289612 | March 22, 2016 | Sambelashvili et al. |
9302115 | April 5, 2016 | Molin et al. |
9333364 | May 10, 2016 | Echt et al. |
9358387 | June 7, 2016 | Suwito et al. |
9358400 | June 7, 2016 | Jacobson |
9364675 | June 14, 2016 | Deterre et al. |
9370663 | June 21, 2016 | Moulder |
9375580 | June 28, 2016 | Bonner et al. |
9375581 | June 28, 2016 | Baru et al. |
9381365 | July 5, 2016 | Kibler et al. |
9393424 | July 19, 2016 | Demmer et al. |
9393436 | July 19, 2016 | Doerr |
9399139 | July 26, 2016 | Demmer et al. |
9399140 | July 26, 2016 | Cho et al. |
9409033 | August 9, 2016 | Jacobson |
9427594 | August 30, 2016 | Bornzin et al. |
9433368 | September 6, 2016 | Stahmann et al. |
9433780 | September 6, 2016 | Régnier et al. |
9457193 | October 4, 2016 | Klimovitch et al. |
9492668 | November 15, 2016 | Sheldon et al. |
9492669 | November 15, 2016 | Demmer et al. |
9492674 | November 15, 2016 | Schmidt et al. |
9492677 | November 15, 2016 | Greenhut et al. |
9511233 | December 6, 2016 | Sambelashvili |
9511236 | December 6, 2016 | Varady et al. |
9511237 | December 6, 2016 | Deterre et al. |
9522276 | December 20, 2016 | Shen et al. |
9522280 | December 20, 2016 | Fishler et al. |
9526522 | December 27, 2016 | Wood et al. |
9526891 | December 27, 2016 | Eggen et al. |
9526909 | December 27, 2016 | Stahmann et al. |
9533163 | January 3, 2017 | Klimovitch et al. |
9561382 | February 7, 2017 | Persson et al. |
9566012 | February 14, 2017 | Greenhut et al. |
9636511 | May 2, 2017 | Carney et al. |
20020032470 | March 14, 2002 | Linberg |
20020035376 | March 21, 2002 | Bardy et al. |
20020035377 | March 21, 2002 | Bardy et al. |
20020035378 | March 21, 2002 | Bardy et al. |
20020035380 | March 21, 2002 | Rissmann et al. |
20020035381 | March 21, 2002 | Bardy et al. |
20020042629 | April 11, 2002 | Bardy et al. |
20020042630 | April 11, 2002 | Bardy et al. |
20020042634 | April 11, 2002 | Bardy et al. |
20020049475 | April 25, 2002 | Bardy et al. |
20020052636 | May 2, 2002 | Bardy et al. |
20020068958 | June 6, 2002 | Bardy et al. |
20020072773 | June 13, 2002 | Bardy et al. |
20020082665 | June 27, 2002 | Haller et al. |
20020091414 | July 11, 2002 | Bardy et al. |
20020095196 | July 18, 2002 | Linberg |
20020099423 | July 25, 2002 | Berg et al. |
20020103510 | August 1, 2002 | Bardy et al. |
20020107545 | August 8, 2002 | Rissmann et al. |
20020107546 | August 8, 2002 | Ostroff et al. |
20020107547 | August 8, 2002 | Erlinger et al. |
20020107548 | August 8, 2002 | Bardy et al. |
20020107549 | August 8, 2002 | Bardy et al. |
20020107559 | August 8, 2002 | Sanders et al. |
20020120299 | August 29, 2002 | Ostroff et al. |
20020173830 | November 21, 2002 | Starkweather et al. |
20020193846 | December 19, 2002 | Pool et al. |
20030009203 | January 9, 2003 | Lebel et al. |
20030028082 | February 6, 2003 | Thompson |
20030040779 | February 27, 2003 | Engmark et al. |
20030041866 | March 6, 2003 | Linberg et al. |
20030045805 | March 6, 2003 | Sheldon et al. |
20030088278 | May 8, 2003 | Bardy et al. |
20030097153 | May 22, 2003 | Bardy et al. |
20030105497 | June 5, 2003 | Zhu et al. |
20030114908 | June 19, 2003 | Flach |
20030144701 | July 31, 2003 | Mehra et al. |
20030187460 | October 2, 2003 | Chin et al. |
20030187461 | October 2, 2003 | Chin |
20040024435 | February 5, 2004 | Leckrone et al. |
20040068302 | April 8, 2004 | Rodgers et al. |
20040087938 | May 6, 2004 | Leckrone et al. |
20040088035 | May 6, 2004 | Guenst et al. |
20040102830 | May 27, 2004 | Williams |
20040127959 | July 1, 2004 | Amundson et al. |
20040133242 | July 8, 2004 | Chapman et al. |
20040147969 | July 29, 2004 | Mann et al. |
20040147973 | July 29, 2004 | Hauser |
20040167558 | August 26, 2004 | Igo et al. |
20040167587 | August 26, 2004 | Thompson |
20040172071 | September 2, 2004 | Bardy et al. |
20040172077 | September 2, 2004 | Chinchoy |
20040172104 | September 2, 2004 | Berg et al. |
20040176817 | September 9, 2004 | Wahlstrand et al. |
20040176818 | September 9, 2004 | Wahlstrand et al. |
20040176830 | September 9, 2004 | Fang |
20040186529 | September 23, 2004 | Bardy et al. |
20040204673 | October 14, 2004 | Flaherty |
20040210292 | October 21, 2004 | Bardy et al. |
20040210293 | October 21, 2004 | Bardy et al. |
20040210294 | October 21, 2004 | Bardy et al. |
20040215308 | October 28, 2004 | Bardy et al. |
20040220624 | November 4, 2004 | Ritscher et al. |
20040220626 | November 4, 2004 | Wagner |
20040220639 | November 4, 2004 | Mulligan et al. |
20040230283 | November 18, 2004 | Prinzen et al. |
20040249431 | December 9, 2004 | Ransbury et al. |
20040260348 | December 23, 2004 | Bakken et al. |
20040267303 | December 30, 2004 | Guenst |
20050061320 | March 24, 2005 | Lee et al. |
20050070962 | March 31, 2005 | Echt et al. |
20050102003 | May 12, 2005 | Grabek et al. |
20050149138 | July 7, 2005 | Min et al. |
20050165466 | July 28, 2005 | Morris et al. |
20050182465 | August 18, 2005 | Ness |
20050203410 | September 15, 2005 | Jenkins |
20050283208 | December 22, 2005 | Von Arx et al. |
20050288743 | December 29, 2005 | Ahn et al. |
20060042830 | March 2, 2006 | Maghribi et al. |
20060052829 | March 9, 2006 | Sun et al. |
20060052830 | March 9, 2006 | Spinelli et al. |
20060064135 | March 23, 2006 | Brockway |
20060064149 | March 23, 2006 | Belacazar et al. |
20060085039 | April 20, 2006 | Hastings et al. |
20060085041 | April 20, 2006 | Hastings et al. |
20060085042 | April 20, 2006 | Hastings et al. |
20060095078 | May 4, 2006 | Tronnes |
20060106442 | May 18, 2006 | Richardson et al. |
20060116746 | June 1, 2006 | Chin |
20060135999 | June 22, 2006 | Bodner et al. |
20060136004 | June 22, 2006 | Cowan et al. |
20060161061 | July 20, 2006 | Echt et al. |
20060200002 | September 7, 2006 | Guenst |
20060206151 | September 14, 2006 | Lu |
20060212079 | September 21, 2006 | Routh et al. |
20060241701 | October 26, 2006 | Markowitz et al. |
20060241705 | October 26, 2006 | Neumann et al. |
20060247672 | November 2, 2006 | Vidlund et al. |
20060259088 | November 16, 2006 | Pastore et al. |
20060265018 | November 23, 2006 | Smith et al. |
20070004979 | January 4, 2007 | Wojciechowicz et al. |
20070016098 | January 18, 2007 | Kim et al. |
20070027508 | February 1, 2007 | Cowan |
20070078490 | April 5, 2007 | Cowan et al. |
20070088394 | April 19, 2007 | Jacobson |
20070088396 | April 19, 2007 | Jacobson |
20070088397 | April 19, 2007 | Jacobson |
20070088398 | April 19, 2007 | Jacobson |
20070088405 | April 19, 2007 | Jacobson |
20070135882 | June 14, 2007 | Drasler et al. |
20070135883 | June 14, 2007 | Drasler et al. |
20070150037 | June 28, 2007 | Hastings et al. |
20070150038 | June 28, 2007 | Hastings et al. |
20070156190 | July 5, 2007 | Cinbis |
20070219525 | September 20, 2007 | Gelfand et al. |
20070219590 | September 20, 2007 | Hastings et al. |
20070225545 | September 27, 2007 | Ferrari |
20070233206 | October 4, 2007 | Frikart et al. |
20070239244 | October 11, 2007 | Morgan et al. |
20070255376 | November 1, 2007 | Michels et al. |
20070276444 | November 29, 2007 | Gelbart et al. |
20070293900 | December 20, 2007 | Sheldon et al. |
20070293904 | December 20, 2007 | Gelbart et al. |
20080004663 | January 3, 2008 | Jorgenson |
20080021505 | January 24, 2008 | Hastings et al. |
20080021519 | January 24, 2008 | De Geest et al. |
20080021532 | January 24, 2008 | Kveen et al. |
20080065183 | March 13, 2008 | Whitehurst et al. |
20080065185 | March 13, 2008 | Worley |
20080071318 | March 20, 2008 | Brooke et al. |
20080109054 | May 8, 2008 | Hastings et al. |
20080119911 | May 22, 2008 | Rosero |
20080130670 | June 5, 2008 | Kim et al. |
20080154139 | June 26, 2008 | Shuros et al. |
20080154322 | June 26, 2008 | Jackson et al. |
20080228234 | September 18, 2008 | Stancer |
20080234771 | September 25, 2008 | Chinchoy et al. |
20080243217 | October 2, 2008 | Wildon |
20080269814 | October 30, 2008 | Rosero |
20080269825 | October 30, 2008 | Chinchoy et al. |
20080275518 | November 6, 2008 | Ghanem et al. |
20080275519 | November 6, 2008 | Ghanem et al. |
20080288039 | November 20, 2008 | Reddy |
20080294208 | November 27, 2008 | Willis et al. |
20080294210 | November 27, 2008 | Rosero |
20080294229 | November 27, 2008 | Friedman et al. |
20080306359 | December 11, 2008 | Zdeblick et al. |
20090018599 | January 15, 2009 | Hastings et al. |
20090024180 | January 22, 2009 | Kisker et al. |
20090036941 | February 5, 2009 | Corbucci |
20090048646 | February 19, 2009 | Katoozi et al. |
20090062895 | March 5, 2009 | Stahmann et al. |
20090082827 | March 26, 2009 | Kveen et al. |
20090082828 | March 26, 2009 | Ostroff |
20090088813 | April 2, 2009 | Brockway et al. |
20090131907 | May 21, 2009 | Chin et al. |
20090135886 | May 28, 2009 | Robertson et al. |
20090143835 | June 4, 2009 | Pastore et al. |
20090171408 | July 2, 2009 | Solem |
20090171414 | July 2, 2009 | Kelly et al. |
20090204163 | August 13, 2009 | Shuros et al. |
20090204170 | August 13, 2009 | Hastings et al. |
20090210024 | August 20, 2009 | M |
20090216292 | August 27, 2009 | Pless et al. |
20090234407 | September 17, 2009 | Hastings et al. |
20090234411 | September 17, 2009 | Sambelashvili et al. |
20090266573 | October 29, 2009 | Engmark et al. |
20090275998 | November 5, 2009 | Bumes et al. |
20090275999 | November 5, 2009 | Burnes et al. |
20090299447 | December 3, 2009 | Jensen et al. |
20100013668 | January 21, 2010 | Kantervik |
20100016911 | January 21, 2010 | Willis et al. |
20100023085 | January 28, 2010 | Wu et al. |
20100030061 | February 4, 2010 | Canfield et al. |
20100030327 | February 4, 2010 | Chatel |
20100042108 | February 18, 2010 | Hibino |
20100056871 | March 4, 2010 | Govari et al. |
20100063375 | March 11, 2010 | Kassab et al. |
20100063562 | March 11, 2010 | Cowan et al. |
20100069983 | March 18, 2010 | Peacock, III |
20100094367 | April 15, 2010 | Sen |
20100114209 | May 6, 2010 | Krause et al. |
20100114214 | May 6, 2010 | Morelli et al. |
20100125281 | May 20, 2010 | Jacobson et al. |
20100168761 | July 1, 2010 | Kassab et al. |
20100168819 | July 1, 2010 | Freeberg |
20100198288 | August 5, 2010 | Ostroff |
20100198304 | August 5, 2010 | Wang |
20100217367 | August 26, 2010 | Belson |
20100228308 | September 9, 2010 | Cowan et al. |
20100234906 | September 16, 2010 | Koh |
20100234924 | September 16, 2010 | Willis |
20100241185 | September 23, 2010 | Mahapatra et al. |
20100249729 | September 30, 2010 | Morris et al. |
20100286744 | November 11, 2010 | Echt et al. |
20100298841 | November 25, 2010 | Prinzen et al. |
20100312309 | December 9, 2010 | Harding |
20110022113 | January 27, 2011 | Zdeblick et al. |
20110071586 | March 24, 2011 | Jacobson |
20110077708 | March 31, 2011 | Ostroff |
20110112600 | May 12, 2011 | Cowan et al. |
20110118588 | May 19, 2011 | Komblau et al. |
20110118810 | May 19, 2011 | Cowan et al. |
20110137187 | June 9, 2011 | Yang et al. |
20110144720 | June 16, 2011 | Cowan et al. |
20110152970 | June 23, 2011 | Jollota et al. |
20110160558 | June 30, 2011 | Rassatt et al. |
20110160565 | June 30, 2011 | Stubbs et al. |
20110160801 | June 30, 2011 | Markowitz et al. |
20110160806 | June 30, 2011 | Lyden et al. |
20110166620 | July 7, 2011 | Cowan et al. |
20110166621 | July 7, 2011 | Cowan et al. |
20110184491 | July 28, 2011 | Kivi |
20110190835 | August 4, 2011 | Brockway et al. |
20110208260 | August 25, 2011 | Jacobson |
20110218587 | September 8, 2011 | Jacobson |
20110230734 | September 22, 2011 | Fain et al. |
20110237967 | September 29, 2011 | Moore et al. |
20110245890 | October 6, 2011 | Brisben et al. |
20110251660 | October 13, 2011 | Griswold |
20110251662 | October 13, 2011 | Griswold et al. |
20110270099 | November 3, 2011 | Ruben et al. |
20110270339 | November 3, 2011 | Murray, III et al. |
20110270340 | November 3, 2011 | Pellegrini et al. |
20110276102 | November 10, 2011 | Cohen |
20110282423 | November 17, 2011 | Jacobson |
20120004527 | January 5, 2012 | Thompson et al. |
20120029323 | February 2, 2012 | Zhao |
20120041508 | February 16, 2012 | Rousso et al. |
20120059433 | March 8, 2012 | Cowan et al. |
20120059436 | March 8, 2012 | Fontaine et al. |
20120065500 | March 15, 2012 | Rogers et al. |
20120078322 | March 29, 2012 | Dal Molin et al. |
20120089198 | April 12, 2012 | Ostroff |
20120093245 | April 19, 2012 | Makdissi et al. |
20120095521 | April 19, 2012 | Hintz |
20120095539 | April 19, 2012 | Khairkhahan et al. |
20120101540 | April 26, 2012 | O'Brien et al. |
20120101553 | April 26, 2012 | Reddy |
20120109148 | May 3, 2012 | Bonner et al. |
20120109149 | May 3, 2012 | Bonner et al. |
20120109236 | May 3, 2012 | Jacobson et al. |
20120109259 | May 3, 2012 | Bond et al. |
20120116489 | May 10, 2012 | Khairkhahan et al. |
20120150251 | June 14, 2012 | Giftakis et al. |
20120158111 | June 21, 2012 | Khairkhahan et al. |
20120165827 | June 28, 2012 | Khairkhahan et al. |
20120172690 | July 5, 2012 | Anderson et al. |
20120172891 | July 5, 2012 | Lee |
20120172892 | July 5, 2012 | Grubac et al. |
20120172942 | July 5, 2012 | Berg |
20120197350 | August 2, 2012 | Roberts et al. |
20120197373 | August 2, 2012 | Khairkhahan et al. |
20120215285 | August 23, 2012 | Tahmasian et al. |
20120232565 | September 13, 2012 | Kveen et al. |
20120245665 | September 27, 2012 | Friedman et al. |
20120277600 | November 1, 2012 | Greenhut |
20120277606 | November 1, 2012 | Ellingson et al. |
20120283795 | November 8, 2012 | Stancer et al. |
20120283807 | November 8, 2012 | Deterre et al. |
20120290025 | November 15, 2012 | Keimel |
20120296381 | November 22, 2012 | Mates |
20120303082 | November 29, 2012 | Dong et al. |
20120316613 | December 13, 2012 | Keefe et al. |
20130012151 | January 10, 2013 | Hankins |
20130023975 | January 24, 2013 | Locsin |
20130035748 | February 7, 2013 | Bonner et al. |
20130041422 | February 14, 2013 | Jacobson |
20130053908 | February 28, 2013 | Smith et al. |
20130053915 | February 28, 2013 | Holmstrom et al. |
20130053921 | February 28, 2013 | Bonner et al. |
20130060298 | March 7, 2013 | Splett et al. |
20130066169 | March 14, 2013 | Rys et al. |
20130072770 | March 21, 2013 | Rao et al. |
20130079798 | March 28, 2013 | Tran et al. |
20130079861 | March 28, 2013 | Reinert et al. |
20130085350 | April 4, 2013 | Schugt et al. |
20130085403 | April 4, 2013 | Gunderson et al. |
20130085550 | April 4, 2013 | Polefko et al. |
20130096649 | April 18, 2013 | Martin et al. |
20130103047 | April 25, 2013 | Steingisser et al. |
20130103109 | April 25, 2013 | Jacobson |
20130110008 | May 2, 2013 | Bourget et al. |
20130110127 | May 2, 2013 | Bornzin et al. |
20130110192 | May 2, 2013 | Tran et al. |
20130110219 | May 2, 2013 | Bornzin et al. |
20130116529 | May 9, 2013 | Min et al. |
20130116738 | May 9, 2013 | Samade et al. |
20130116740 | May 9, 2013 | Bornzin |
20130116741 | May 9, 2013 | Bornzin et al. |
20130123872 | May 16, 2013 | Bornzin et al. |
20130123875 | May 16, 2013 | Varady et al. |
20130131591 | May 23, 2013 | Berthiaume et al. |
20130131693 | May 23, 2013 | Berthiaume et al. |
20130138006 | May 30, 2013 | Bornzin et al. |
20130150695 | June 13, 2013 | Biela et al. |
20130150911 | June 13, 2013 | Perschbacher et al. |
20130150912 | June 13, 2013 | Perschbacher et al. |
20130184776 | July 18, 2013 | Shuros et al. |
20130196703 | August 1, 2013 | Masoud et al. |
20130197609 | August 1, 2013 | Moore et al. |
20130231710 | September 5, 2013 | Jacobson |
20130238072 | September 12, 2013 | Deterre et al. |
20130238073 | September 12, 2013 | Makdissi et al. |
20130253342 | September 26, 2013 | Griswold et al. |
20130253343 | September 26, 2013 | Waldhauser et al. |
20130253344 | September 26, 2013 | Griswold et al. |
20130253345 | September 26, 2013 | Griswold et al. |
20130253346 | September 26, 2013 | Griswold et al. |
20130253347 | September 26, 2013 | Griswold et al. |
20130261497 | October 3, 2013 | Pertijs et al. |
20130265144 | October 10, 2013 | Banna et al. |
20130268042 | October 10, 2013 | Hastings et al. |
20130274828 | October 17, 2013 | Willis |
20130274847 | October 17, 2013 | Ostroff |
20130282070 | October 24, 2013 | Cowan et al. |
20130282073 | October 24, 2013 | Cowan et al. |
20130296727 | November 7, 2013 | Sullivan et al. |
20130303872 | November 14, 2013 | Taff et al. |
20130324825 | December 5, 2013 | Ostroff et al. |
20130325081 | December 5, 2013 | Karst et al. |
20130345770 | December 26, 2013 | Dianaty et al. |
20140012344 | January 9, 2014 | Hastings et al. |
20140018876 | January 16, 2014 | Ostroff |
20140018877 | January 16, 2014 | Demmer et al. |
20140031836 | January 30, 2014 | Ollivier |
20140039570 | February 6, 2014 | Carroll et al. |
20140039591 | February 6, 2014 | Drasler et al. |
20140043146 | February 13, 2014 | Makdissi et al. |
20140046395 | February 13, 2014 | Regnier et al. |
20140046420 | February 13, 2014 | Moore et al. |
20140058240 | February 27, 2014 | Mothilal et al. |
20140058494 | February 27, 2014 | Ostroff et al. |
20140074114 | March 13, 2014 | Khairkhahan et al. |
20140074186 | March 13, 2014 | Faltys et al. |
20140094891 | April 3, 2014 | Pare et al. |
20140100627 | April 10, 2014 | Min |
20140107723 | April 17, 2014 | Hou et al. |
20140121719 | May 1, 2014 | Bonner et al. |
20140121720 | May 1, 2014 | Bonner et al. |
20140121722 | May 1, 2014 | Sheldon et al. |
20140128935 | May 8, 2014 | Kumar et al. |
20140135865 | May 15, 2014 | Hastings et al. |
20140142648 | May 22, 2014 | Smith et al. |
20140148675 | May 29, 2014 | Nordstrom et al. |
20140148815 | May 29, 2014 | Wenzel et al. |
20140155950 | June 5, 2014 | Hastings et al. |
20140169162 | June 19, 2014 | Romano et al. |
20140172060 | June 19, 2014 | Bornzin et al. |
20140180306 | June 26, 2014 | Grubac et al. |
20140180366 | June 26, 2014 | Edlund |
20140207149 | July 24, 2014 | Hastings et al. |
20140207210 | July 24, 2014 | Willis et al. |
20140214104 | July 31, 2014 | Greenhut et al. |
20140222098 | August 7, 2014 | Baru et al. |
20140222109 | August 7, 2014 | Moulder |
20140228913 | August 14, 2014 | Molin et al. |
20140236172 | August 21, 2014 | Hastings et al. |
20140243848 | August 28, 2014 | Auricchio et al. |
20140255298 | September 11, 2014 | Cole et al. |
20140257324 | September 11, 2014 | Fain |
20140257422 | September 11, 2014 | Herken |
20140257444 | September 11, 2014 | Cole et al. |
20140276929 | September 18, 2014 | Foster et al. |
20140303704 | October 9, 2014 | Suwito et al. |
20140309706 | October 16, 2014 | Jacobson |
20140379041 | December 25, 2014 | Foster |
20150025612 | January 22, 2015 | Haasl et al. |
20150039041 | February 5, 2015 | Smith et al. |
20150051609 | February 19, 2015 | Schmidt et al. |
20150051610 | February 19, 2015 | Schmidt et al. |
20150051611 | February 19, 2015 | Schmidt et al. |
20150051612 | February 19, 2015 | Schmidt et al. |
20150051613 | February 19, 2015 | Schmidt et al. |
20150051614 | February 19, 2015 | Schmidt et al. |
20150051615 | February 19, 2015 | Schmidt et al. |
20150051616 | February 19, 2015 | Haasl et al. |
20150051682 | February 19, 2015 | Schmidt et al. |
20150057520 | February 26, 2015 | Foster et al. |
20150057558 | February 26, 2015 | Stahmann et al. |
20150057721 | February 26, 2015 | Stahmann et al. |
20150088155 | March 26, 2015 | Stahmann et al. |
20150105836 | April 16, 2015 | Bonner et al. |
20150157861 | June 11, 2015 | Aghassian |
20150173655 | June 25, 2015 | Demmer et al. |
20150190638 | July 9, 2015 | Smith et al. |
20150196756 | July 16, 2015 | Stahmann et al. |
20150196757 | July 16, 2015 | Stahmann et al. |
20150196758 | July 16, 2015 | Stahmann et al. |
20150196769 | July 16, 2015 | Stahmann et al. |
20150217119 | August 6, 2015 | Nikolski et al. |
20150221898 | August 6, 2015 | Chi et al. |
20150224315 | August 13, 2015 | Stahmann |
20150224320 | August 13, 2015 | Stahmann |
20150258345 | September 17, 2015 | Smith et al. |
20150290468 | October 15, 2015 | Zhang |
20150297905 | October 22, 2015 | Greenhut et al. |
20150297907 | October 22, 2015 | Zhang |
20150305637 | October 29, 2015 | Greenhut et al. |
20150305638 | October 29, 2015 | Zhang |
20150305639 | October 29, 2015 | Greenhut et al. |
20150305640 | October 29, 2015 | Reinke et al. |
20150305641 | October 29, 2015 | Stadler et al. |
20150305642 | October 29, 2015 | Reinke et al. |
20150306374 | October 29, 2015 | Seifert et al. |
20150306375 | October 29, 2015 | Marshall et al. |
20150306406 | October 29, 2015 | Crutchfield et al. |
20150306407 | October 29, 2015 | Crutchfield et al. |
20150306408 | October 29, 2015 | Greenhut et al. |
20150321016 | November 12, 2015 | O'Brien et al. |
20150328459 | November 19, 2015 | Chin et al. |
20160015322 | January 21, 2016 | Anderson et al. |
20160023000 | January 28, 2016 | Cho et al. |
20160030757 | February 4, 2016 | Jacobson |
20160033177 | February 4, 2016 | Barot et al. |
20160121127 | May 5, 2016 | Klimovitch et al. |
20160121128 | May 5, 2016 | Fishler et al. |
20160121129 | May 5, 2016 | Persson et al. |
20160213919 | July 28, 2016 | Suwito et al. |
20160213937 | July 28, 2016 | Reinke et al. |
20160213939 | July 28, 2016 | Carney et al. |
20160228026 | August 11, 2016 | Jackson |
20160317825 | November 3, 2016 | Jacobson |
20160367823 | December 22, 2016 | Cowan et al. |
20170014629 | January 19, 2017 | Ghosh et al. |
20170035315 | February 9, 2017 | Jackson |
20170043173 | February 16, 2017 | Sharma et al. |
20170043174 | February 16, 2017 | Greenhut et al. |
2008279789 | October 2011 | AU |
2008329620 | May 2014 | AU |
2014203793 | July 2014 | AU |
1003904 | January 1977 | CA |
202933393 | May 2013 | CN |
0362611 | April 1990 | EP |
503823 | September 1992 | EP |
1702648 | September 2006 | EP |
1904166 | June 2011 | EP |
2433675 | January 2013 | EP |
2441491 | January 2013 | EP |
2452721 | November 2013 | EP |
1948296 | January 2014 | EP |
2662113 | January 2014 | EP |
2471452 | December 2014 | EP |
2760541 | May 2016 | EP |
2833966 | May 2016 | EP |
2000051373 | February 2000 | JP |
2002502640 | January 2002 | JP |
2004512105 | April 2004 | JP |
2005508208 | March 2005 | JP |
2005245215 | September 2005 | JP |
2008540040 | November 2008 | JP |
5199867 | February 2013 | JP |
9500202 | January 1995 | WO |
9636134 | November 1996 | WO |
9724981 | July 1997 | WO |
9826840 | June 1998 | WO |
9939767 | August 1999 | WO |
0234330 | January 2003 | WO |
02098282 | May 2003 | WO |
2005000206 | April 2005 | WO |
2005042089 | May 2005 | WO |
2006065394 | June 2006 | WO |
2006086435 | August 2006 | WO |
2006113659 | October 2006 | WO |
2006124833 | May 2007 | WO |
2007073435 | June 2007 | WO |
2007075974 | July 2007 | WO |
2009006531 | January 2009 | WO |
2012054102 | April 2012 | WO |
2013080038 | June 2013 | WO |
2013098644 | August 2013 | WO |
2013184787 | December 2013 | WO |
2014120769 | August 2014 | WO |
- US 8,886,318 B2, 11/2014, Jacobson et al. (withdrawn)
- Asirvatham et al., “Intramyocardial Pacing and Sensing for the Enhancement of Cardiac Stimulation and Sensing Specificity,” PACE, vol. 30, pp. 748-754, Jun. 2007.
- Henz et al., “Synchronous Ventricular Pacing without Crossing the Tricuspid Valve or Entering the Coronary Sinus-Preliminary Results,” Journal of Cardiovascular Electrophysiology, vol. 20(12):1391-1397, Dec. 2009. doi: 10.1111/j.0540-8167.2009.01556.x.
- “Instructions for Use System 1, Leadless Cardiac Pacemaker (LCP) and Delivery Catheter,” Nanostim Leadless Pacemakers, pp. 1-28, 2013.
- Hachisuka et al., “Development and Performance Analysis of an Intra-Body Communication Device,” The 12th International Conference on Solid State Sensors, Actuators and Microsystems, vol. 4A1.3, pp. 1722-1725, 2003.
- Notification of Transmittal of the International Search Report and the Written Opinion of the International Searching Authority, or the Declaration, Jan. 29, 2016, 15 pages.
- Seyedi et al., “A Survey on Intrabody Communications for Body Area Network Application,” IEEE Transactions on Biomedical Engineering,vol. 60(8): 2067-2079, 2013.
- Spickler et al., “Totally Self-Contained Intracardiac Pacemaker,” Journal of Electrocardiology, vol. 3(384): 324-331, 1970.
- Wegmüller, “Intra-Body Communication for Biomedical Sensor Networks,” Diss. ETH, No. 17323, 1-173, 2007.
Type: Grant
Filed: Dec 28, 2016
Date of Patent: Feb 2, 2021
Patent Publication Number: 20170182327
Assignee: CARDIAC PACEMAKERS, INC. (St. Paul, MN)
Inventor: Lili Liu (Maple Grove, MN)
Primary Examiner: Eun Hwa Kim
Application Number: 15/392,668
International Classification: A61N 1/375 (20060101); A61N 1/368 (20060101); A61B 5/042 (20060101); A61B 5/00 (20060101); A61N 1/05 (20060101); A61N 1/365 (20060101); A61N 1/372 (20060101);