User actuated liquid drug transfer devices for use in ready-to-use (RTU) liquid drug transfer assemblages
Liquid drug transfer device for use in a Ready-To-Use liquid drug transfer assemblage for establishing flow communication between a liquid source and an injection vial. The liquid drug transfer device includes an injection vial adapter for mounting on an intact injection vial having an injection vial stopper without puncturing same, a liquid source adapter for attachment to a liquid source, a dual ended liquid transfer member for flow communication with the liquid source and puncturing an injection vial stopper, a safety catch mechanism requiring an initial manual linear sliding extension for priming the liquid drug transfer device, an extension limit arrangement for limiting the linear sliding extension, and a snap fit securing arrangement for securing the liquid source adapter on the injection vial adapter after actuation.
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This application is a Section 371 of International Application No. PCT/IL2018/050336, filed Mar. 23, 2018, which was published in the English language on Oct. 4, 2018 under International Publication No. WO 2018/178971 A1, which claims priority under 35 U.S.C. § 119(b) to Israeli Application No. 251458, filed Mar. 29, 2017, the disclosures of which are incorporated herein by reference in their entirety.
FIELD OF THE INVENTIONThe invention relates to liquid drug transfer devices suitable for use in Ready-To-Use (RTU) liquid drug transfer assemblages.
BACKGROUND OF THE INVENTIONReady-To-Use (RTU) liquid drug transfer assemblages include a liquid drug transfer device and at least one intact non-punctured injection vial attached thereto. Such RTU assemblages require a user actuation for puncturing an injection vial for enabling flow communication therewith. Such RTU assemblages can be generally classified into two types as follows: First, a liquid drug transfer device with a user removable injection vial. The liquid drug transfer device can be supplied with a pre-attached injection vial or alternatively a user attaches same in a telescopic snap fit mounting action as a prior step to user actuation for puncturing. And second, a liquid drug transfer device with an irremovable injection vial except by applying extreme force damaging the liquid drug transfer device and/or the injection vial. Such RTU arrangements are particularly beneficial for wide range of usage environments including inter alia home use, out-patient clinic use, and the like.
Commonly owned PCT International Application No. PCT/IL2010/000777 entitled Vial Assemblage with Vial and Pre-Attached Fluid Transfer Device and published under PCT International Publication No. WO 2011/039747 discloses RTU assemblages of the first type. The RTU assemblages include a fluid transfer device having a pre-attached removable injection vial for use with a needleless syringe. The fluid transfer devices include an elongated tubular flow member having a connector for sealing flow communication with a needleless syringe and a puncturing cannula for puncturing an injection. The puncturing cannula tip is embedded in an injection vial stopper. WO 2011/039747
Commonly owned PCT International Application No. PCT/IL2013/050721 entitled Liquid Drug Transfer Devices employing Manual Rotation for Dual Flow Communication Step Actuations and published under PCT International Publication No. WO 2014/033710 discloses RTU assemblages of both types for enabling flow communication between an injection vial and a liquid source in the form of another injection vial, an infusion liquid container, and the like. The RTU assemblages include liquid drug transfer devices employing different mechanical arrangements for converting manual rotation into a linear displacement for flow communication purposes. Suitable mechanical arrangements include inter alia a screw thread arrangement, a pin and track arrangement, and the like.
Commonly owned PCT International Application No. PCT/IL2014/050327 entitled Drug Container Closure for Mounting on Open-topped Drug Container to form Drug Reconstitution Assemblage for use with Needleless Syringe and published under PCT International Publication No. WO 2014/170888 discloses RTU assemblages of the second type for use with a needleless syringe. The RTU assemblages include a fluid transfer member with an integral needleless syringe connector and a puncturing cannula. The fluid transfer member is manually disposed along a diametric inverted L-shaped track pair from an initial non-puncturing position to a puncturing position. The inverted L-shaped track pair includes one-way snap fit members to prevent a user returning the fluid transfer member to an earlier position and indicating progress of the user activation.
SUMMARY OF THE INVENTIONThe present invention is directed towards liquid drug transfer devices for use in Ready-To-Use (RTU) liquid drug transfer assemblages. The liquid drug transfer devices include an injection vial adapter for telescopic mounting on a non-punctured injection vial having an injection vial stopper and an uppermost injection vial surface without puncturing same. An injection vial adapter can be designed to either enable or prevent removal of an injection vial. The liquid drug transfer devices include a liquid source adapter intended for flow communication with a range of liquid sources. Suitable liquid sources include inter alia a needleless syringe with a male connector, an infusion liquid container, and the like.
A liquid source adapter is mounted on an injection vial adapter and configured for telescopically receiving the injection vial adapter therein on a manual linear sliding compaction of a liquid drug transfer device from an initial pre-actuated height H1 to a final actuated height H2 where H2<H1. The liquid drug transfer devices each include a dual ended liquid transfer member with a puncturing tip for puncturing an injection vial stopper. A dual ended liquid transfer member can be either integral formed with a liquid source adapter or a discrete component interdisposed between a liquid source adapter and an injection vial adapter depending on an intended liquid source. The puncturing tip is deployed above an uppermost injection vial surface in a pre-actuated state of a liquid drug transfer device and punctures through the injection vial stopper in the actuated state.
The liquid drug transfer devices include an integral safety catch mechanism for precluding inadvertent user actuation leading to inadvertent puncturing an intact non-punctured injection vial. The safety catch mechanism requires an initial manual linear sliding extension for imparting a short extension of the liquid source adapter from the injection vial adapter for priming the liquid drug transfer device ready for a subsequent manual linear sliding compaction whereupon the liquid source adapter snugly receives the injection vial adapter therein. The compaction stroke is necessarily longer than the extension stroke because the compaction stroke includes causing the puncturing tip to puncture the injection vial stopper. The liquid drug transfer devices include an extension limit arrangement for limiting the extension of the liquid source adapter from the vial injection adapter on priming the safety catch mechanism from its initial pre-actuated state. The liquid drug transfer device includes a snap fit securing arrangement for securing the liquid source adapter on the injection vial adapter in the actuated state.
In order to understand the invention and to see how it can be carried out in practice, preferred embodiments will now be described, by way of non-limiting examples only, with reference to the accompanying drawings in which similar parts are likewise numbered, and in which:
The liquid drug transfer device 30A has a longitudinal device centerline 31 and includes an injection vial adapter 32 for telescopic snap fit mounting on the injection vial 10 and a liquid source adapter 33 initially mounted on the injection vial adapter 32 in a pre-actuated state. The liquid drug transfer device 30A includes a safety catch mechanism 34 for priming the liquid drug transfer device 30A ready for actuation thereby preventing inadvertent user actuation to puncture the intact non-punctured injection vial 10. The liquid drug transfer device 30A includes an extension limit arrangement 36 for limiting linear sliding extension of the liquid source adapter 33 from the vial injection adapter 32 on priming the liquid drug transfer device 30A. The liquid drug transfer device 30A includes a snap-fit securing arrangement 37 for securing the liquid source adapter 33 on the injection vial adapter 32 in an actuated state.
The injection vial adapter 32 includes a transverse injection vial adapter top surface 38 and a downward depending injection vial adapter skirt 39 for telescopic mounting on the vial crown 13. The downward depending injection vial adapter skirt 39 has a lowermost injection vial adapter skirt rim 39A. The injection vial adapter top surface 38 has a throughgoing injection vial adapter top surface aperture 41 overlying the uppermost injection vial surface 19. The injection vial adapter skirt 39 includes four longitudinal slits 42 forming a diametric resiliently flexible flex member pair 43. The injection vial adapter skirt 39 includes a diametric resiliently flexible longitudinal directed flex member pair 44 orthogonal to the flex member pair 43.
The flex member pair 43 each includes an inward directed protrusion 46 for snap fit under the vial crown 13. The flex member pair 43 each includes a longitudinal slit pair 47 forming a central longitudinal directed flex securing member 48 constituting a component of both the extension limit arrangement 36 and the snap fit securing arrangement 37. The flex securing members 48 each have a free end 49 flush with the injector vial adapter top surface 38. The free ends 49 are formed with an outward directed protrusion 51 having an inclined leading surface 52.
The diametric resiliently flexible longitudinal directed flex member pair 44 terminate at an inward directed hook 53 disposed toward the injection vial adapter top surface 38.
The liquid source adapter 33 includes a cap-like member 54 having a transverse liquid source adapter top surface 56 and a downward depending liquid source adapter skirt 57 for telescopically receiving the injection vial adapter 32 therein in an actuated state of the liquid drug transfer device 30A. The liquid source adapter 33 includes an integral dual ended liquid transfer member 58 having an upward liquid transfer member end 59 and terminating in a downward puncturing tip 61 for puncturing the injection vial stopper 18 for flow communication with the vial tube 12. The upward liquid transfer member end 59 is constituted by an upright liquid drug access port 62 protruding from the liquid source adapter top surface 56. The liquid drug access port 62 is preferably constituted by a female connector as shown for flow communication with a needleless syringe, a male connector, and the like.
The liquid source adapter skirt 57 has a lowermost liquid source adapter skirt rim 63 and is formed with a diametric cutaway pair 64 each with a resiliently flexible longitudinal directed flex member 66 terminating at an outward directed hook 67 adjacent with the liquid source adapter skirt rim 63. The safety catch mechanism 34 includes a diametric safety catch pair 68 each being constituted by an inward directed hook 53 and an outward directed hook 67.
The liquid source adapter skirt 57 includes a diametric extension limit aperture pair 69 adjacent the liquid source adapter skirt rim 63 and a diametric securing aperture pair 71 adjacent the liquid source adapter top surface 56. The extension limit aperture pair 69 each has an uppermost transverse rim 72 and a lowermost transverse rim 73.
The heights of the liquid drug transfer device 30A at its three different states: pre-actuated state, intermediate primed state and actuated state are indicated between the female connector 62 and the lowermost injection vial adapter skirt rim 39A. Accordingly, the liquid drug transfer device 30A has a pre-actuated height H1 (see
The liquid drug transfer device 30B includes a three component construction as opposed to the liquid drug transfer device 30A's two component construction. The liquid drug transfer device 30B includes an injection vial adapter 81, a liquid source adapter 82 and a discrete dual ended liquid transfer member 83 interdisposed between the injection vial adapter 81 and the liquid source adapter 82. The dual ended liquid transfer member 83 includes an upward liquid transfer member end 84 also terminating in a puncturing tip similar to the puncturing tip 61. The dual ended liquid transfer member 83 includes an intermediate circular flange 86.
The injection vial adapter 81 includes an upward sleeve 87 mounted on the injection vial adapter top surface 38 for supporting the circular flange 86 in the liquid drug transfer device 30B's pre-actuated state and the intermediate primed state. The upward sleeve 87 is formed with the diametric flex member pair 44 formed with the inward directed hooks 53 and the diametric flex securing member pair 48.
The liquid source adapter top surface 56 is formed with an injection port connector 89 for slidingly receiving the injection port 21 and a diametric inward directed injection port stopper pair 91 for stopping the insertion of the injection port 21 therein. The upward liquid transfer member end 84 underlies the injection port 21 in the liquid drug transfer device 30B's pre-actuated state.
The liquid drug transfer device 30B has a pre-actuated height H1, an actuated height H2 and an intermediate primed height H3 similar to the liquid drug transfer device 30A. The heights are indicated between the liquid source adapter top surface 56 and the lowermost injection vial adapter skirt rim 39A. The height difference H1−H2 equals the displacement that the liquid drug transfer device 30B has to compact from its pre-actuated state in which the puncturing tip 61 overlies the uppermost injection port surface 19 and the upward liquid transfer member end 84 underlies the injection port 21 to its actuated state in which the puncturing tip 61 protrudes through the injection vial stopper 18 and the upward liquid transfer member end 84 punctures through the injection port 21.
While particular embodiments of the present invention are illustrated and described, it would be obvious to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the invention.
Claims
1. A user actuated liquid drug transfer device for use in a Ready-To-Use (RTU) liquid drug transfer assemblage for establishing flow communication between a liquid source and an injection vial, the injection vial including a closed end vial tube, and a tubular vial crown having a crown opening stopped by an injection vial stopper, the injection vial having an uppermost injection vial surface, the liquid drug transfer device having a longitudinal device centerline and comprising:
- (a) an injection vial adapter having a transverse injection vial adapter top surface and a downward depending injection vial adapter skirt intended for telescopic mounting on the vial crown, said transverse injection vial adapter top surface including a transverse injection vial adapter top surface aperture along the longitudinal device centerline overlying the uppermost injection vial surface on said telescopic mounting on the injection vial;
- (b) a liquid source adapter intended for attachment to the liquid source, said liquid source adapter including a transverse liquid source adapter top surface and a downward depending liquid source adapter skirt mounted on said injection vial adapter in a pre-actuated state of the liquid drug transfer device and configured for telescopically receiving said injection vial adapter therein in an actuated state of the liquid drug transfer device on user compaction of the liquid drug transfer device from said pre-actuated state to an actuated state;
- (c) a dual ended liquid transfer member having an upward liquid transfer member end for flow communication with the liquid source and a downward liquid transfer member end in flow communication with said upward liquid transfer member end and terminating in a puncturing tip for puncturing the injection vial stopper for flow communication with the vial tube, said puncturing tip overlying the uppermost injection vial surface in said pre-actuated state and puncturing through the injection vial stopper in said actuated state;
- (d) a safety catch mechanism requiring an initial manual linear sliding extension for extending said liquid source adapter from said injection vial adapter for priming the liquid drug transfer device to an intermediate primed state, thereby enabling said user compaction from said pre-actuated state to said actuated state;
- (e) an extension limit arrangement for limiting said linear sliding extension of said liquid source adapter from said vial injection adapter in said intermediate primed state; and
- (f) a snap fit securing arrangement for securing said liquid source adapter on said injection vial adapter in said actuated state.
2. The device according to claim 1 wherein said safety catch mechanism having at least one safety catch each constituted by said liquid source adapter having a downward depending resiliently flexible longitudinal directed flex member terminating at an outward directed hook and said injection vial adapter having an upward resiliently flexible longitudinal directed flex member terminating at an inward directed hook, said outward directed hook engaging said inward directed hook in said pre-actuated state, said outward directed hook being disengaged from said inward directed hook in said intermediate primed state and said outward directed hook sliding past said inward directed hook on compaction of the liquid drug transfer device from said intermediate primed state to said actuated state wherein said downward depending resiliently flexible longitudinal directed flex member and said upward resiliently flexible longitudinal directed flex member are substantially co-extensive in said actuated state.
3. The device according to claim 1 wherein said injection vial adapter includes a longitudinal directed flex member with an outward directed protrusion, said liquid source adapter skirt includes a longitudinal directed elongated extension limit aperture disposed remote from said liquid source adapter top surface and a securing aperture disposed adjacent said liquid source adapter top surface, said outward directed protrusion engaging said extension limit aperture for limiting said extension of said liquid source adapter from said injection vial adapter in said intermediate primed state and said outward directed protrusion engaging said securing aperture for securing said liquid source adapter on said injection vial adapter in said actuated state.
4. The device according to claim 1 for use with a male connector and wherein said liquid source adapter is integrally formed with said dual ended liquid transfer member and said upward liquid transfer member end is constituted by an access transfer port for flow communication with the male connector.
5. The device according to claim 1 for use with an infusion bag having an injection port and wherein said dual ended liquid transfer member is a discrete component interdisposed between said injection vial adapter and said liquid source adapter and said dual ended liquid transfer member terminates in a second puncturing tip constituting said upward liquid transfer member end for puncturing the injection port in said actuated state.
6. The device according to claim 1 for use with an infusion bag having an administration port and wherein the liquid drug transfer device includes a trifurcated body having an IV spike for sliding sealed insertion into the infusion bag's administration port, a substitute IV port for sliding sealed insertion of an infusion set, and said liquid source adapter,
- said liquid source adapter being integrally formed with said dual ended liquid transfer member and said upward liquid transfer member end being in continuous flow communication with said IV spike and said substitute IV port.
7. A Ready-To-Use (RTU) liquid drug transfer assemblage including a liquid drug transfer device according to claim 1.
62333 | February 1867 | Holl |
247975 | October 1881 | Wickes |
254444 | February 1882 | Vogel |
300060 | June 1884 | Ford |
1021681 | March 1912 | Jennings |
1704817 | March 1929 | Ayers |
1930944 | October 1933 | Schmitz, Jr. |
2326490 | August 1943 | Perelson |
2560162 | July 1951 | Garwood |
2748769 | June 1956 | Huber |
2830587 | April 1958 | Everett |
2931668 | April 1960 | Baley |
2968497 | January 1961 | Treleman |
3059643 | October 1962 | Barton |
D198499 | June 1964 | Harautuneian |
3225763 | December 1965 | Waterman |
3277893 | October 1966 | Clark |
3308822 | March 1967 | De Luca |
3484849 | December 1969 | Huebner et al. |
3618637 | November 1971 | Santomieri |
3757981 | September 1973 | Harris, Sr. et al. |
3782365 | January 1974 | Pinna |
3788524 | January 1974 | Davis et al. |
3822700 | July 1974 | Pennington |
3826261 | July 1974 | Killinger |
3872992 | March 1975 | Larson |
3885607 | May 1975 | Peltier |
3938520 | February 17, 1976 | Scislowicz et al. |
3957052 | May 18, 1976 | Topham |
3977555 | August 31, 1976 | Larson |
3993063 | November 23, 1976 | Larrabee |
4020839 | May 3, 1977 | Klapp |
4026128 | May 31, 1977 | Blanco |
4051852 | October 4, 1977 | Villari |
D247975 | May 23, 1978 | Luther |
D248568 | July 18, 1978 | Ismach |
4109670 | August 29, 1978 | Slagel |
4121585 | October 24, 1978 | Becker, Jr. |
4161178 | July 17, 1979 | Genese |
4187848 | February 12, 1980 | Taylor |
D254444 | March 11, 1980 | Levine |
4203067 | May 13, 1980 | Fitzky et al. |
4203443 | May 20, 1980 | Genese |
4210173 | July 1, 1980 | Choksi et al. |
D257286 | October 7, 1980 | Folkman |
4253501 | March 3, 1981 | Ogle |
4296786 | October 27, 1981 | Brignola |
4303067 | December 1, 1981 | Connolly et al. |
4312349 | January 26, 1982 | Cohen |
4314586 | February 9, 1982 | Folkman |
4328802 | May 11, 1982 | Curley et al. |
4335717 | June 22, 1982 | Bujan et al. |
D267199 | December 7, 1982 | Koenig |
4376634 | March 15, 1983 | Prior et al. |
D268871 | May 3, 1983 | Benham et al. |
4392850 | July 12, 1983 | Elias et al. |
D270282 | August 23, 1983 | Gross |
4410321 | October 18, 1983 | Pearson et al. |
4411662 | October 25, 1983 | Pearson |
D271421 | November 15, 1983 | Fetterman |
4434823 | March 6, 1984 | Hudspith |
4465471 | August 14, 1984 | Harris et al. |
4475915 | October 9, 1984 | Sloane |
4493348 | January 15, 1985 | Lemmons |
4505709 | March 19, 1985 | Froning et al. |
4507113 | March 26, 1985 | Dunlap |
D280018 | August 6, 1985 | Scott |
4532969 | August 6, 1985 | Kwaan |
4564054 | January 14, 1986 | Gustavsson |
4573993 | March 4, 1986 | Hoag et al. |
4576211 | March 18, 1986 | Valentini et al. |
4581014 | April 8, 1986 | Millerd et al. |
4585446 | April 29, 1986 | Kempf |
4588396 | May 13, 1986 | Stroebel et al. |
4588403 | May 13, 1986 | Weiss et al. |
D284603 | July 8, 1986 | Loignon |
4604093 | August 5, 1986 | Brown et al. |
4607671 | August 26, 1986 | Aalto et al. |
4614437 | September 30, 1986 | Buehler |
4638975 | January 27, 1987 | Iuchi et al. |
4639019 | January 27, 1987 | Mittleman |
4667927 | May 26, 1987 | Oscarsson |
4675020 | June 23, 1987 | McPhee |
4676530 | June 30, 1987 | Nordgren et al. |
4683975 | August 4, 1987 | Booth et al. |
4697622 | October 6, 1987 | Swift et al. |
4721133 | January 26, 1988 | Sundblom |
4729401 | March 8, 1988 | Raines |
4735608 | April 5, 1988 | Sardam |
4743229 | May 10, 1988 | Chu |
4743243 | May 10, 1988 | Vaillancourt |
4752292 | June 21, 1988 | Lopez et al. |
4758235 | July 19, 1988 | Tu |
4759756 | July 26, 1988 | Forman et al. |
4778447 | October 18, 1988 | Velde et al. |
4787898 | November 29, 1988 | Raines |
4797898 | January 10, 1989 | Martinez |
D300060 | February 28, 1989 | Molgaard-Nielsen |
4804366 | February 14, 1989 | Zdeb et al. |
4826492 | May 2, 1989 | Magasi |
4832690 | May 23, 1989 | Kuu |
4834152 | May 30, 1989 | Howson et al. |
D303013 | August 22, 1989 | Konopka |
4857062 | August 15, 1989 | Russell |
4865592 | September 12, 1989 | Rycroft |
4871463 | October 3, 1989 | Taylor et al. |
4898209 | February 6, 1990 | Zbed |
4909290 | March 20, 1990 | Coccia |
4919596 | April 24, 1990 | Slate et al. |
4927423 | May 22, 1990 | Malmborg |
4931040 | June 5, 1990 | Haber et al. |
4932944 | June 12, 1990 | Jagger et al. |
4967797 | November 6, 1990 | Manska |
D314050 | January 22, 1991 | Sone |
D314622 | February 12, 1991 | Andersson et al. |
4997430 | March 5, 1991 | Van der Heiden et al. |
5006114 | April 9, 1991 | Rogers et al. |
5035686 | July 30, 1991 | Crittenden et al. |
5041105 | August 20, 1991 | D'Alo et al. |
5045066 | September 3, 1991 | Scheuble et al. |
5049129 | September 17, 1991 | Zdeb et al. |
5053015 | October 1, 1991 | Gross |
5061248 | October 29, 1991 | Sacco |
5088996 | February 18, 1992 | Kopfer et al. |
5096575 | March 17, 1992 | Cosack |
5104387 | April 14, 1992 | Pokorney et al. |
5113904 | May 19, 1992 | Aslanian |
5122124 | June 16, 1992 | Novacek et al. |
5125908 | June 30, 1992 | Cohen |
5125915 | June 30, 1992 | Berry et al. |
D328788 | August 18, 1992 | Sagae et al. |
5171230 | December 15, 1992 | Eland et al. |
5201705 | April 13, 1993 | Berglund et al. |
5201717 | April 13, 1993 | Wyatt et al. |
5203771 | April 20, 1993 | Melker et al. |
5203775 | April 20, 1993 | Frank et al. |
5211638 | May 18, 1993 | Dudar et al. |
5232029 | August 3, 1993 | Knox et al. |
5232109 | August 3, 1993 | Tirrell et al. |
5242432 | September 7, 1993 | DeFrank |
5247972 | September 28, 1993 | Tetreault |
D341420 | November 16, 1993 | Conn |
5269768 | December 14, 1993 | Cheung |
5270219 | December 14, 1993 | DeCastro et al. |
5279576 | January 18, 1994 | Loo et al. |
5288290 | February 22, 1994 | Brody |
5300034 | April 5, 1994 | Behnke et al. |
5301685 | April 12, 1994 | Guirguis |
5304163 | April 19, 1994 | Bonnici et al. |
5304165 | April 19, 1994 | Haber et al. |
5308483 | May 3, 1994 | Sklar et al. |
5312377 | May 17, 1994 | Dalton |
5328474 | July 12, 1994 | Raines |
D349648 | August 16, 1994 | Tirrell et al. |
5334163 | August 2, 1994 | Sinnett |
5334179 | August 2, 1994 | Poli et al. |
5342346 | August 30, 1994 | Honda et al. |
5344417 | September 6, 1994 | Wadsworth, Jr. |
5348544 | September 20, 1994 | Sweeney et al. |
5348548 | September 20, 1994 | Meyer et al. |
5350372 | September 27, 1994 | Ikeda et al. |
5364386 | November 15, 1994 | Fukuoka et al. |
5364387 | November 15, 1994 | Sweeney |
5374264 | December 20, 1994 | Wadsworth, Jr. |
5385547 | January 31, 1995 | Wong et al. |
5397303 | March 14, 1995 | Sancoff et al. |
D357733 | April 25, 1995 | Matkovich |
5429614 | July 4, 1995 | Fowles et al. |
5433330 | July 18, 1995 | Yatsko et al. |
5445630 | August 29, 1995 | Richmond |
5445631 | August 29, 1995 | Uchida |
D362718 | September 26, 1995 | Deily et al. |
5451374 | September 19, 1995 | Molina |
5454805 | October 3, 1995 | Brony |
5464111 | November 7, 1995 | Vacek et al. |
5464123 | November 7, 1995 | Scarrow |
5466219 | November 14, 1995 | Lynn et al. |
5466220 | November 14, 1995 | Brenneman |
5470327 | November 28, 1995 | Helgren et al. |
5471994 | December 5, 1995 | Guirguis |
5472022 | December 5, 1995 | Michel et al. |
5478337 | December 26, 1995 | Okamoto et al. |
5482446 | January 9, 1996 | Williamson et al. |
5492147 | February 20, 1996 | Challender et al. |
5496274 | March 5, 1996 | Graves et al. |
D369406 | April 30, 1996 | Niedospial et al. |
5505714 | April 9, 1996 | Dassa et al. |
5509433 | April 23, 1996 | Paradis |
5515871 | May 14, 1996 | Bittner et al. |
5520659 | May 28, 1996 | Hedges |
5526853 | June 18, 1996 | McPhee et al. |
5527306 | June 18, 1996 | Haining |
5531695 | July 2, 1996 | Swisher |
5547471 | August 20, 1996 | Thompson et al. |
5549577 | August 27, 1996 | Siegel et al. |
5554128 | September 10, 1996 | Hedges |
5562686 | October 8, 1996 | Sauer et al. |
5562696 | October 8, 1996 | Nobles et al. |
5566729 | October 22, 1996 | Grabenkort et al. |
5569191 | October 29, 1996 | Meyer |
5573281 | November 12, 1996 | Keller |
5578015 | November 26, 1996 | Robb |
5583052 | December 10, 1996 | Portnoff et al. |
5584819 | December 17, 1996 | Kopfer |
5591143 | January 7, 1997 | Trombley, III et al. |
5603706 | February 18, 1997 | Wyatt et al. |
5607439 | March 4, 1997 | Yoon |
5611576 | March 18, 1997 | Guala |
5616203 | April 1, 1997 | Stevens |
5636660 | June 10, 1997 | Pfleiderer et al. |
5637101 | June 10, 1997 | Shillington |
5641010 | June 24, 1997 | Maier |
5645538 | July 8, 1997 | Richmond |
5647845 | July 15, 1997 | Haber et al. |
5651776 | July 29, 1997 | Appling et al. |
5653686 | August 5, 1997 | Coulter et al. |
5658133 | August 19, 1997 | Anderson et al. |
5672160 | September 30, 1997 | Osterlind et al. |
5674195 | October 7, 1997 | Truthan |
5676346 | October 14, 1997 | Leinsing |
5685845 | November 11, 1997 | Grimard |
D388172 | December 23, 1997 | Cipes |
5699821 | December 23, 1997 | Paradis |
5702019 | December 30, 1997 | Grimard |
5718346 | February 17, 1998 | Weiler |
5728087 | March 17, 1998 | Niedospial, Jr. |
D393722 | April 21, 1998 | Fangrow, Jr. et al. |
5738144 | April 14, 1998 | Rogers |
5743312 | April 28, 1998 | Pfeifer et al. |
5746733 | May 5, 1998 | Capaccio et al. |
5752942 | May 19, 1998 | Doyle et al. |
5755696 | May 26, 1998 | Caizza |
5766211 | June 16, 1998 | Wood et al. |
5772630 | June 30, 1998 | Ljungquist |
5772652 | June 30, 1998 | Zielinski |
RE35841 | July 7, 1998 | Frank et al. |
5776116 | July 7, 1998 | Lopez et al. |
5782872 | July 21, 1998 | Muller |
5806831 | September 15, 1998 | Paradis |
5810792 | September 22, 1998 | Fangrow, Jr. et al. |
5814020 | September 29, 1998 | Gross |
D399559 | October 13, 1998 | Molina |
5817082 | October 6, 1998 | Niedospial, Jr. et al. |
5820621 | October 13, 1998 | Yale et al. |
5827262 | October 27, 1998 | Neftel et al. |
5832971 | November 10, 1998 | Yale et al. |
5833213 | November 10, 1998 | Ryan |
5834744 | November 10, 1998 | Risman |
5839715 | November 24, 1998 | Leinsing |
5853406 | December 29, 1998 | Masuda et al. |
D405522 | February 9, 1999 | Hoenig et al. |
5868710 | February 9, 1999 | Battiato et al. |
5871110 | February 16, 1999 | Grimard et al. |
5873872 | February 23, 1999 | Thibault et al. |
5879337 | March 9, 1999 | Kuracina et al. |
5879345 | March 9, 1999 | Aneas |
5887633 | March 30, 1999 | Yale et al. |
5890610 | April 6, 1999 | Jansen et al. |
5891129 | April 6, 1999 | Daubert et al. |
5893397 | April 13, 1999 | Peterson et al. |
5897526 | April 27, 1999 | Vaillancourt |
5899468 | May 4, 1999 | Apps et al. |
5902280 | May 11, 1999 | Powles et al. |
5902298 | May 11, 1999 | Niedospial, Jr. et al. |
D410740 | June 8, 1999 | Molina |
5911710 | June 15, 1999 | Barry et al. |
5919182 | July 6, 1999 | Avallone |
5921419 | July 13, 1999 | Niedospial, Jr. et al. |
5924584 | July 20, 1999 | Hellstrom et al. |
5925029 | July 20, 1999 | Jansen et al. |
5935112 | August 10, 1999 | Stevens et al. |
5941848 | August 24, 1999 | Nishimoto et al. |
5941850 | August 24, 1999 | Shah et al. |
5944700 | August 31, 1999 | Nguyen et al. |
5954104 | September 21, 1999 | Daubert et al. |
5968022 | October 19, 1999 | Saito |
5971181 | October 26, 1999 | Niedospial, Jr. et al. |
5971965 | October 26, 1999 | Mayer |
5989237 | November 23, 1999 | Fowles et al. |
6003566 | December 21, 1999 | Thibault et al. |
6004278 | December 21, 1999 | Botich et al. |
6019750 | February 1, 2000 | Fowles et al. |
6022339 | February 8, 2000 | Fowles et al. |
6036171 | March 14, 2000 | Weinheimer et al. |
6039093 | March 21, 2000 | Mrotzek et al. |
6039302 | March 21, 2000 | Cote, Sr. et al. |
D422357 | April 4, 2000 | Niedospial, Jr. et al. |
6063068 | May 16, 2000 | Fowles et al. |
D427308 | June 27, 2000 | Zinger |
D427309 | June 27, 2000 | Molina |
6070623 | June 6, 2000 | Aneas |
6071270 | June 6, 2000 | Fowles et al. |
6080132 | June 27, 2000 | Cole et al. |
D428141 | July 11, 2000 | Brotspies et al. |
6086762 | July 11, 2000 | Guala |
6089541 | July 18, 2000 | Weinheimer et al. |
6090091 | July 18, 2000 | Fowles et al. |
6090093 | July 18, 2000 | Thibault et al. |
6092692 | July 25, 2000 | Riskin |
D430291 | August 29, 2000 | Jansen et al. |
6099511 | August 8, 2000 | Devos et al. |
6113068 | September 5, 2000 | Ryan |
6113571 | September 5, 2000 | Zinger et al. |
6113583 | September 5, 2000 | Fowles et al. |
6117114 | September 12, 2000 | Paradis |
D431864 | October 10, 2000 | Jansen |
6139534 | October 31, 2000 | Niedospial, Jr. et al. |
6142446 | November 7, 2000 | Leinsing |
6146362 | November 14, 2000 | Turnbull et al. |
6149623 | November 21, 2000 | Reynolds |
6156025 | December 5, 2000 | Niedospial, Jr. et al. |
6159192 | December 12, 2000 | Fowles et al. |
6168037 | January 2, 2001 | Grimard |
6171287 | January 9, 2001 | Lynn et al. |
6171293 | January 9, 2001 | Rowley et al. |
6173852 | January 16, 2001 | Browne |
6173868 | January 16, 2001 | DeJonge |
6174304 | January 16, 2001 | Weston |
6179822 | January 30, 2001 | Niedospial, Jr. |
6179823 | January 30, 2001 | Niedospial, Jr. |
6186997 | February 13, 2001 | Gabbard et al. |
6206861 | March 27, 2001 | Mayer |
6221041 | April 24, 2001 | Russo |
6221054 | April 24, 2001 | Martin et al. |
6221065 | April 24, 2001 | Davis |
6238372 | May 29, 2001 | Zinger et al. |
6245044 | June 12, 2001 | Daw et al. |
D445501 | July 24, 2001 | Niedospial, Jr. |
D445895 | July 31, 2001 | Svendsen |
6253804 | July 3, 2001 | Safabash |
6258078 | July 10, 2001 | Thilly |
6280430 | August 28, 2001 | Neftel et al. |
6290688 | September 18, 2001 | Lopez et al. |
6296621 | October 2, 2001 | Masuda et al. |
6299131 | October 9, 2001 | Ryan |
6343629 | February 5, 2002 | Wessman et al. |
6348044 | February 19, 2002 | Coletti et al. |
6358236 | March 19, 2002 | DeFoggi et al. |
6364866 | April 2, 2002 | Furr et al. |
6378576 | April 30, 2002 | Thibault et al. |
6378714 | April 30, 2002 | Jansen et al. |
6379340 | April 30, 2002 | Zinger et al. |
D457954 | May 28, 2002 | Wallace et al. |
6382442 | May 7, 2002 | Thibault et al. |
6386397 | May 14, 2002 | Brotspies et al. |
6408897 | June 25, 2002 | Laurent et al. |
6409708 | June 25, 2002 | Wessman |
6440107 | August 27, 2002 | Trombley, III et al. |
6453949 | September 24, 2002 | Chau |
6453956 | September 24, 2002 | Safabash |
6474375 | November 5, 2002 | Spero et al. |
6478788 | November 12, 2002 | Aneas |
D468015 | December 31, 2002 | Horppu |
6499617 | December 31, 2002 | Niedospial, Jr. et al. |
6503240 | January 7, 2003 | Niedospial, Jr. et al. |
6503244 | January 7, 2003 | Hayman |
6520932 | February 18, 2003 | Taylor |
6524278 | February 25, 2003 | Campbell et al. |
6524295 | February 25, 2003 | Daubert et al. |
D472316 | March 25, 2003 | Douglas et al. |
6530903 | March 11, 2003 | Wang et al. |
6537263 | March 25, 2003 | Aneas |
D472630 | April 1, 2003 | Douglas et al. |
6544246 | April 8, 2003 | Niedospial, Jr. |
6551299 | April 22, 2003 | Miyoshi et al. |
6558365 | May 6, 2003 | Zinger et al. |
6571837 | June 3, 2003 | Jansen et al. |
6572591 | June 3, 2003 | Mayer |
6575955 | June 10, 2003 | Azzolini |
6581593 | June 24, 2003 | Rubin et al. |
6582415 | June 24, 2003 | Fowles et al. |
D476731 | July 1, 2003 | Cise et al. |
6591876 | July 15, 2003 | Safabash |
6599273 | July 29, 2003 | Lopez |
6601721 | August 5, 2003 | Jansen et al. |
6626309 | September 30, 2003 | Jansen et al. |
6632201 | October 14, 2003 | Mathias et al. |
6638244 | October 28, 2003 | Reynolds |
D482121 | November 11, 2003 | Harding et al. |
D482447 | November 18, 2003 | Harding et al. |
6651956 | November 25, 2003 | Miller |
6652509 | November 25, 2003 | Helgren et al. |
D483487 | December 9, 2003 | Harding et al. |
D483869 | December 16, 2003 | Tran et al. |
6656433 | December 2, 2003 | Sasso |
6666852 | December 23, 2003 | Niedospial, Jr. |
6681810 | January 27, 2004 | Weston |
6681946 | January 27, 2004 | Jansen et al. |
6682509 | January 27, 2004 | Lopez |
6692478 | February 17, 2004 | Paradis |
6692829 | February 17, 2004 | Stubler et al. |
6695829 | February 24, 2004 | Hellstrom et al. |
6699229 | March 2, 2004 | Zinger et al. |
6706022 | March 16, 2004 | Leinsing et al. |
6706031 | March 16, 2004 | Manera |
6715520 | April 6, 2004 | Andreasson et al. |
6729370 | May 4, 2004 | Norton et al. |
6736798 | May 18, 2004 | Ohkubo et al. |
6745998 | June 8, 2004 | Doyle |
6746438 | June 8, 2004 | Amissolle |
6752180 | June 22, 2004 | Delay |
D495416 | August 31, 2004 | Dimeo et al. |
D496457 | September 21, 2004 | Prais et al. |
6802490 | October 12, 2004 | Leinsing et al. |
6832994 | December 21, 2004 | Niedospial, Jr. et al. |
6852103 | February 8, 2005 | Fowles et al. |
6875203 | April 5, 2005 | Fowles et al. |
6875205 | April 5, 2005 | Leinsing |
6878131 | April 12, 2005 | Novacek et al. |
6884253 | April 26, 2005 | McFarlane |
6890328 | May 10, 2005 | Fowles et al. |
D506256 | June 14, 2005 | Miyoshi et al. |
6901975 | June 7, 2005 | Aramata et al. |
6945417 | September 20, 2005 | Jansen et al. |
6948522 | September 27, 2005 | Newbrough et al. |
6949086 | September 27, 2005 | Ferguson et al. |
6951613 | October 4, 2005 | Reif et al. |
6957745 | October 25, 2005 | Thibault et al. |
6960164 | November 1, 2005 | O'Heeron |
6972002 | December 6, 2005 | Thorne |
6979318 | December 27, 2005 | McDonald et al. |
RE38996 | February 28, 2006 | Crawford et al. |
6994315 | February 7, 2006 | Ryan et al. |
6997916 | February 14, 2006 | Simas, Jr. et al. |
6997917 | February 14, 2006 | Niedospial, Jr. et al. |
7024968 | April 11, 2006 | Raudabough et al. |
7070589 | July 4, 2006 | Lolachi et al. |
7074216 | July 11, 2006 | Fowles et al. |
7083600 | August 1, 2006 | Meloul |
7086431 | August 8, 2006 | D'Antonio et al. |
7097637 | August 29, 2006 | Triplett et al. |
7100890 | September 5, 2006 | Cote, Sr. et al. |
7140401 | November 28, 2006 | Wilcox et al. |
7150735 | December 19, 2006 | Hickle |
7192423 | March 20, 2007 | Wong |
7195623 | March 27, 2007 | Burroughs et al. |
7241285 | July 10, 2007 | Dikeman |
7294122 | November 13, 2007 | Kubo et al. |
7306199 | December 11, 2007 | Leinsing et al. |
D561348 | February 5, 2008 | Zinger et al. |
7326188 | February 5, 2008 | Russell et al. |
7326194 | February 5, 2008 | Zinger et al. |
7350764 | April 1, 2008 | Raybuck |
7354422 | April 8, 2008 | Riesenberger et al. |
7354427 | April 8, 2008 | Fangrow |
7425209 | September 16, 2008 | Fowles et al. |
7435246 | October 14, 2008 | Zihlmann |
D580558 | November 11, 2008 | Shigesada et al. |
7452348 | November 18, 2008 | Hasegawa |
7470257 | December 30, 2008 | Norton et al. |
7470265 | December 30, 2008 | Brugger et al. |
7472932 | January 6, 2009 | Weber et al. |
7488297 | February 10, 2009 | Flaherty |
7491197 | February 17, 2009 | Jansen et al. |
7497848 | March 3, 2009 | Leinsing et al. |
7523967 | April 28, 2009 | Steppe |
7530546 | May 12, 2009 | Ryan et al. |
D595420 | June 30, 2009 | Suzuki et al. |
D595421 | June 30, 2009 | Suzuki et al. |
7540863 | June 2, 2009 | Haindl |
7540865 | June 2, 2009 | Griffin et al. |
7544191 | June 9, 2009 | Peluso et al. |
D595862 | July 7, 2009 | Suzuki et al. |
D595863 | July 7, 2009 | Suzuki et al. |
7611487 | November 3, 2009 | Woehr et al. |
7611502 | November 3, 2009 | Daly |
7615041 | November 10, 2009 | Sullivan et al. |
7628779 | December 8, 2009 | Aneas |
7632261 | December 15, 2009 | Zinger et al. |
D608900 | January 26, 2010 | Giraud et al. |
7654995 | February 2, 2010 | Marren et al. |
7670326 | March 2, 2010 | Shemesh |
7695445 | April 13, 2010 | Yuki |
7704229 | April 27, 2010 | Moberg et al. |
D616090 | May 18, 2010 | Kawamura |
7713247 | May 11, 2010 | Lopez |
7717886 | May 18, 2010 | Lopez |
7722090 | May 25, 2010 | Burton et al. |
D616984 | June 1, 2010 | Gilboa |
7731678 | June 8, 2010 | Tennican et al. |
7743799 | June 29, 2010 | Mosler et al. |
7744581 | June 29, 2010 | Wallen et al. |
7757901 | July 20, 2010 | Welp |
7758082 | July 20, 2010 | Weigel et al. |
7758560 | July 20, 2010 | Connell et al. |
7762524 | July 27, 2010 | Cawthon et al. |
7766304 | August 3, 2010 | Phillips |
7771383 | August 10, 2010 | Truitt et al. |
D624641 | September 28, 2010 | Boclet |
7799009 | September 21, 2010 | Niedospial, Jr. et al. |
7803140 | September 28, 2010 | Fangrow, Jr. |
D627216 | November 16, 2010 | Fulginiti |
D630732 | January 11, 2011 | Lev et al. |
7862537 | January 4, 2011 | Zinger et al. |
7867215 | January 11, 2011 | Akerlund et al. |
7879018 | February 1, 2011 | Zinger et al. |
7883499 | February 8, 2011 | Fangrow |
7895216 | February 22, 2011 | Longshaw et al. |
D634007 | March 8, 2011 | Zinger et al. |
7900659 | March 8, 2011 | Whitley et al. |
D637713 | May 10, 2011 | Nord et al. |
7963954 | June 21, 2011 | Kavazov |
D641080 | July 5, 2011 | Zinger et al. |
7985216 | July 26, 2011 | Daily et al. |
D644104 | August 30, 2011 | Maeda et al. |
7993328 | August 9, 2011 | Whitley |
8007461 | August 30, 2011 | Huo et al. |
8012132 | September 6, 2011 | Lum et al. |
8016809 | September 13, 2011 | Zinger et al. |
8021325 | September 20, 2011 | Zinger et al. |
8025653 | September 27, 2011 | Capitaine et al. |
8025683 | September 27, 2011 | Morrison |
8029472 | October 4, 2011 | Leinsing et al. |
8038123 | October 18, 2011 | Ruschke et al. |
8066688 | November 29, 2011 | Zinger et al. |
8070739 | December 6, 2011 | Zinger et al. |
8075550 | December 13, 2011 | Nord et al. |
8096525 | January 17, 2012 | Ryan |
8105314 | January 31, 2012 | Fangrow, Jr. |
D654166 | February 14, 2012 | Lair |
D655017 | February 28, 2012 | Mosler et al. |
8122923 | February 28, 2012 | Kraus et al. |
8123736 | February 28, 2012 | Kraushaar et al. |
D655071 | March 6, 2012 | Davila |
D657461 | April 10, 2012 | Schembre et al. |
8152779 | April 10, 2012 | Cabiri |
8157784 | April 17, 2012 | Rogers |
8167863 | May 1, 2012 | Yow |
8172824 | May 8, 2012 | Pfeifer et al. |
8177768 | May 15, 2012 | Leinsing |
8182452 | May 22, 2012 | Mansour et al. |
8187248 | May 29, 2012 | Zihlmann |
8196614 | June 12, 2012 | Kriheli |
8197459 | June 12, 2012 | Jansen et al. |
8211069 | July 3, 2012 | Fangrow, Jr. |
8225959 | July 24, 2012 | Lambrecht |
8241268 | August 14, 2012 | Whitley |
8262628 | September 11, 2012 | Fangrow, Jr. |
8262641 | September 11, 2012 | Vedrine et al. |
8267127 | September 18, 2012 | Kriheli |
D669980 | October 30, 2012 | Lev et al. |
8287513 | October 16, 2012 | Ellstrom et al. |
8328784 | December 11, 2012 | Jensen et al. |
D673673 | January 1, 2013 | Wang |
D674084 | January 8, 2013 | Linnenschmidt |
D674088 | January 8, 2013 | Lev et al. |
8348898 | January 8, 2013 | Cabiri |
D681230 | April 30, 2013 | Mosler et al. |
8454573 | June 4, 2013 | Wyatt et al. |
8469939 | June 25, 2013 | Fangrow, Jr. |
8475404 | July 2, 2013 | Foshee et al. |
8480645 | July 9, 2013 | Choudhury et al. |
8480646 | July 9, 2013 | Nord et al. |
8506548 | August 13, 2013 | Okiyama |
8511352 | August 20, 2013 | Kraus et al. |
8512309 | August 20, 2013 | Shemesh et al. |
D690009 | September 17, 2013 | Schembre et al. |
D690418 | September 24, 2013 | Rosenquist |
8523837 | September 3, 2013 | Wiggins et al. |
8545476 | October 1, 2013 | Ariagno et al. |
8551067 | October 8, 2013 | Zinger et al. |
8556879 | October 15, 2013 | Okiyama |
8562582 | October 22, 2013 | Tuckwell et al. |
8608723 | December 17, 2013 | Lev et al. |
8628508 | January 14, 2014 | Weitzel et al. |
8636689 | January 28, 2014 | Halili, Jr. et al. |
8684992 | April 1, 2014 | Sullivan et al. |
8684994 | April 1, 2014 | Lev et al. |
8752598 | June 17, 2014 | Denenburg et al. |
D714935 | October 7, 2014 | Nishioka et al. |
D717406 | November 11, 2014 | Stanley et al. |
D717948 | November 18, 2014 | Strong et al. |
D719650 | December 16, 2014 | Arinobe et al. |
D720067 | December 23, 2014 | Rosenquist |
D720451 | December 30, 2014 | Denenburg et al. |
D720452 | December 30, 2014 | Jordan |
8900212 | December 2, 2014 | Kubo |
8905994 | December 9, 2014 | Lev et al. |
8915882 | December 23, 2014 | Cabiri |
D720850 | January 6, 2015 | Hsia et al. |
D732660 | June 23, 2015 | Ohashi |
D732664 | June 23, 2015 | Woehr et al. |
D733291 | June 30, 2015 | Wang |
D733292 | June 30, 2015 | Rogers |
D733293 | June 30, 2015 | Rogers |
9072827 | July 7, 2015 | Cabiri |
9089475 | July 28, 2015 | Fangrow |
D738494 | September 8, 2015 | Kashmirian |
D741457 | October 20, 2015 | Guest |
9149575 | October 6, 2015 | Cabiri |
D750235 | February 23, 2016 | Maurice |
9254242 | February 9, 2016 | Mueller et al. |
D757933 | May 31, 2016 | Lev et al. |
9339438 | May 17, 2016 | Lev et al. |
9393365 | July 19, 2016 | Cabiri |
9414991 | August 16, 2016 | Sanders et al. |
9486391 | November 8, 2016 | Shemesh |
9492610 | November 15, 2016 | Cabiri |
9511190 | December 6, 2016 | Cabiri |
9522234 | December 20, 2016 | Cabiri |
D794183 | August 8, 2017 | Lev et al. |
9763855 | September 19, 2017 | Fangrow |
9801786 | October 31, 2017 | Lev et al. |
10206854 | February 19, 2019 | Wu et al. |
10376654 | August 13, 2019 | Sanders et al. |
20010000347 | April 19, 2001 | Hellstrom et al. |
20010025671 | October 4, 2001 | Safabash |
20010029360 | October 11, 2001 | Miyoshi et al. |
20010051793 | December 13, 2001 | Weston |
20020017328 | February 14, 2002 | Loo |
20020055711 | May 9, 2002 | Lavi et al. |
20020065488 | May 30, 2002 | Suzuki et al. |
20020066715 | June 6, 2002 | Niedospial |
20020087118 | July 4, 2002 | Reynolds et al. |
20020087141 | July 4, 2002 | Zinger et al. |
20020087144 | July 4, 2002 | Zinger et al. |
20020104584 | August 8, 2002 | Spero et al. |
20020115980 | August 22, 2002 | Niedospial |
20020121496 | September 5, 2002 | Thiebault et al. |
20020123736 | September 5, 2002 | Fowles et al. |
20020127150 | September 12, 2002 | Sasso |
20020128628 | September 12, 2002 | Fathallah |
20020138045 | September 26, 2002 | Moen |
20020173752 | November 21, 2002 | Polzin |
20020193777 | December 19, 2002 | Aneas |
20030028156 | February 6, 2003 | Juliar |
20030036725 | February 20, 2003 | Lavi et al. |
20030068354 | April 10, 2003 | Reif et al. |
20030069550 | April 10, 2003 | Sharp |
20030073971 | April 17, 2003 | Saker |
20030100866 | May 29, 2003 | Reynolds |
20030109846 | June 12, 2003 | Zinger et al. |
20030120209 | June 26, 2003 | Jensen et al. |
20030135159 | July 17, 2003 | Daily et al. |
20030153895 | August 14, 2003 | Leinsing |
20030187420 | October 2, 2003 | Akerlund et al. |
20030191445 | October 9, 2003 | Wallen et al. |
20030195479 | October 16, 2003 | Kuracina et al. |
20030199827 | October 23, 2003 | Thorne |
20030199846 | October 23, 2003 | Fowles |
20030199847 | October 23, 2003 | Akerlund et al. |
20030205843 | November 6, 2003 | Adams |
20030236543 | December 25, 2003 | Brenneman et al. |
20040010207 | January 15, 2004 | Flaherty et al. |
20040024354 | February 5, 2004 | Reynolds |
20040039365 | February 26, 2004 | Aramata et al. |
20040044327 | March 4, 2004 | Hasegawa |
20040073189 | April 15, 2004 | Wyatt et al. |
20040143218 | July 22, 2004 | Das |
20040143226 | July 22, 2004 | Marsden |
20040153047 | August 5, 2004 | Blank et al. |
20040158172 | August 12, 2004 | Hancock |
20040162540 | August 19, 2004 | Walenciak et al. |
20040167472 | August 26, 2004 | Howell et al. |
20040181192 | September 16, 2004 | Cuppy |
20040186424 | September 23, 2004 | Hjertman |
20040199139 | October 7, 2004 | Fowles et al. |
20040204699 | October 14, 2004 | Hanly et al. |
20040217315 | November 4, 2004 | Doyle |
20040225274 | November 11, 2004 | Jansen et al. |
20040236305 | November 25, 2004 | Jansen et al. |
20040249341 | December 9, 2004 | Newbrough et al. |
20040255952 | December 23, 2004 | Carlsen et al. |
20050015070 | January 20, 2005 | Delnevo et al. |
20050016626 | January 27, 2005 | Wilcox et al. |
20050049553 | March 3, 2005 | Triplett et al. |
20050055008 | March 10, 2005 | Paradis et al. |
20050082828 | April 21, 2005 | Wicks et al. |
20050124964 | June 9, 2005 | Niedospial et al. |
20050137523 | June 23, 2005 | Wyatt et al. |
20050137566 | June 23, 2005 | Fowles et al. |
20050148994 | July 7, 2005 | Leinsing |
20050159706 | July 21, 2005 | Wilkinson et al. |
20050159724 | July 21, 2005 | Enerson |
20050182383 | August 18, 2005 | Wallen |
20050209554 | September 22, 2005 | Landau |
20050261637 | November 24, 2005 | Miller |
20050277896 | December 15, 2005 | Messerli et al. |
20060030832 | February 9, 2006 | Niedospial et al. |
20060079834 | April 13, 2006 | Tennican et al. |
20060089594 | April 27, 2006 | Landau |
20060089603 | April 27, 2006 | Truitt et al. |
20060095015 | May 4, 2006 | Hobbs et al. |
20060106360 | May 18, 2006 | Wong |
20060135948 | June 22, 2006 | Varma |
20060155257 | July 13, 2006 | Reynolds |
20060161192 | July 20, 2006 | Young |
20060173410 | August 3, 2006 | Moberg et al. |
20060178646 | August 10, 2006 | Harris et al. |
20060195029 | August 31, 2006 | Shults et al. |
20060212004 | September 21, 2006 | Atil |
20060253084 | November 9, 2006 | Nordgren |
20060259004 | November 16, 2006 | Connell et al. |
20070016381 | January 18, 2007 | Kamath et al. |
20070024995 | February 1, 2007 | Hayashi |
20070060904 | March 15, 2007 | Vedrine et al. |
20070078428 | April 5, 2007 | Reynolds et al. |
20070079894 | April 12, 2007 | Kraus et al. |
20070083164 | April 12, 2007 | Barrelle et al. |
20070088252 | April 19, 2007 | Pestotnik et al. |
20070088293 | April 19, 2007 | Fangrow |
20070088313 | April 19, 2007 | Zinger et al. |
20070106218 | May 10, 2007 | Yodfat et al. |
20070106244 | May 10, 2007 | Mosler et al. |
20070112324 | May 17, 2007 | Hamedi-Sangsari |
20070156112 | July 5, 2007 | Walsh |
20070167904 | July 19, 2007 | Zinger et al. |
20070167912 | July 19, 2007 | Causey et al. |
20070191760 | August 16, 2007 | Iguchi et al. |
20070191764 | August 16, 2007 | Zihlmann |
20070191767 | August 16, 2007 | Hennessy et al. |
20070203451 | August 30, 2007 | Murakami et al. |
20070219483 | September 20, 2007 | Kitani et al. |
20070244447 | October 18, 2007 | Capitaine et al. |
20070244461 | October 18, 2007 | Fangrow |
20070244462 | October 18, 2007 | Fangrow |
20070244463 | October 18, 2007 | Warren et al. |
20070249995 | October 25, 2007 | Van Manen |
20070255202 | November 1, 2007 | Kitani et al. |
20070265574 | November 15, 2007 | Tennican et al. |
20070265581 | November 15, 2007 | Funamura et al. |
20070270778 | November 22, 2007 | Zinger et al. |
20070287953 | December 13, 2007 | Ziv et al. |
20070299404 | December 27, 2007 | Katoh et al. |
20080009789 | January 10, 2008 | Zinger et al. |
20080009822 | January 10, 2008 | Enerson |
20080015496 | January 17, 2008 | Hamedi-Sangsari |
20080132851 | June 5, 2008 | Shaw et al. |
20080135051 | June 12, 2008 | Lee |
20080172024 | July 17, 2008 | Yow |
20080188799 | August 7, 2008 | Mueller-Beckhaus et al. |
20080195049 | August 14, 2008 | Thalmann et al. |
20080208138 | August 28, 2008 | Lim et al. |
20080215015 | September 4, 2008 | Cindrich et al. |
20080249473 | October 9, 2008 | Rutti et al. |
20080249479 | October 9, 2008 | Zinger et al. |
20080249498 | October 9, 2008 | Fangrow |
20080262465 | October 23, 2008 | Zinger et al. |
20080269687 | October 30, 2008 | Chong et al. |
20080275407 | November 6, 2008 | Scheurer |
20080287905 | November 20, 2008 | Hiejima et al. |
20080294100 | November 27, 2008 | de Costa et al. |
20080306439 | December 11, 2008 | Nelson et al. |
20080312634 | December 18, 2008 | Helmerson et al. |
20090012492 | January 8, 2009 | Zihlmann |
20090043253 | February 12, 2009 | Podaima |
20090054834 | February 26, 2009 | Zinger et al. |
20090054852 | February 26, 2009 | Takano et al. |
20090062767 | March 5, 2009 | Van Antwerp et al. |
20090076360 | March 19, 2009 | Brister et al. |
20090082750 | March 26, 2009 | Denenburg et al. |
20090139724 | June 4, 2009 | Gray et al. |
20090143758 | June 4, 2009 | Okiyama |
20090177177 | July 9, 2009 | Zinger et al. |
20090177178 | July 9, 2009 | Pedersen |
20090187140 | July 23, 2009 | Racz |
20090216103 | August 27, 2009 | Brister et al. |
20090216212 | August 27, 2009 | Fangrow, Jr. |
20090267011 | October 29, 2009 | Hatton |
20090299325 | December 3, 2009 | Vedrine et al. |
20090318946 | December 24, 2009 | Tamesada |
20090326506 | December 31, 2009 | Hasegawa et al. |
20100010443 | January 14, 2010 | Morgan et al. |
20100016811 | January 21, 2010 | Smith |
20100022985 | January 28, 2010 | Sullivan et al. |
20100030181 | February 4, 2010 | Helle et al. |
20100036319 | February 11, 2010 | Drake et al. |
20100076397 | March 25, 2010 | Reed et al. |
20100087786 | April 8, 2010 | Zinger et al. |
20100137827 | June 3, 2010 | Warren et al. |
20100137831 | June 3, 2010 | Tsals |
20100152658 | June 17, 2010 | Hanson et al. |
20100160889 | June 24, 2010 | Smith et al. |
20100162548 | July 1, 2010 | Leidig |
20100168664 | July 1, 2010 | Zinger et al. |
20100168712 | July 1, 2010 | Tuckwell et al. |
20100179506 | July 15, 2010 | Shemesh et al. |
20100198148 | August 5, 2010 | Zinger et al. |
20100204670 | August 12, 2010 | Kraushaar et al. |
20100228220 | September 9, 2010 | Zinger et al. |
20100241088 | September 23, 2010 | Ranalletta et al. |
20100274184 | October 28, 2010 | Chun |
20100274202 | October 28, 2010 | Hyde et al. |
20100286661 | November 11, 2010 | Raday et al. |
20100312220 | December 9, 2010 | Kalitzki |
20110004143 | January 6, 2011 | Beiriger et al. |
20110004184 | January 6, 2011 | Proksch et al. |
20110044850 | February 24, 2011 | Solomon et al. |
20110054440 | March 3, 2011 | Lewis |
20110087164 | April 14, 2011 | Mosler et al. |
20110125056 | May 26, 2011 | Merchant |
20110144584 | June 16, 2011 | Wozencroft |
20110160655 | June 30, 2011 | Hanson et al. |
20110160701 | June 30, 2011 | Wyatt et al. |
20110172636 | July 14, 2011 | Aasmul |
20110175347 | July 21, 2011 | Okiyama |
20110218511 | September 8, 2011 | Yokoyama |
20110224640 | September 15, 2011 | Kuhn et al. |
20110230856 | September 22, 2011 | Kyle et al. |
20110264037 | October 27, 2011 | Foshee et al. |
20110264069 | October 27, 2011 | Bochenko |
20110276007 | November 10, 2011 | Denenburg |
20110319827 | December 29, 2011 | Leinsing et al. |
20120022344 | January 26, 2012 | Kube |
20120022469 | January 26, 2012 | Alpert |
20120053555 | March 1, 2012 | Ariagno et al. |
20120059332 | March 8, 2012 | Woehr et al. |
20120059346 | March 8, 2012 | Sheppard et al. |
20120067429 | March 22, 2012 | Mosler et al. |
20120071819 | March 22, 2012 | Bruggemann et al. |
20120078214 | March 29, 2012 | Finke et al. |
20120123382 | May 17, 2012 | Kubo |
20120184938 | July 19, 2012 | Lev et al. |
20120215182 | August 23, 2012 | Mansour et al. |
20120220977 | August 30, 2012 | Yow |
20120220978 | August 30, 2012 | Lev et al. |
20120265163 | October 18, 2012 | Cheng et al. |
20120271229 | October 25, 2012 | Lev et al. |
20120296307 | November 22, 2012 | Holt et al. |
20120310203 | December 6, 2012 | Khaled et al. |
20120323172 | December 20, 2012 | Lev et al. |
20120323187 | December 20, 2012 | Iwase et al. |
20120323210 | December 20, 2012 | Lev et al. |
20130046269 | February 21, 2013 | Lev et al. |
20130053814 | February 28, 2013 | Mueller-Beckhaus et al. |
20130096493 | April 18, 2013 | Kubo et al. |
20130110049 | May 2, 2013 | Cronenberg et al. |
20130144248 | June 6, 2013 | Putter et al. |
20130199669 | August 8, 2013 | Moy et al. |
20130226100 | August 29, 2013 | Lev |
20130231630 | September 5, 2013 | Kraus et al. |
20130237904 | September 12, 2013 | Deneburg et al. |
20130253448 | September 26, 2013 | Baron et al. |
20130289530 | October 31, 2013 | Wyatt et al. |
20140020793 | January 23, 2014 | Denenburg et al. |
20140096862 | April 10, 2014 | Aneas |
20140150911 | June 5, 2014 | Hanner et al. |
20140194854 | July 10, 2014 | Tsals |
20140221940 | August 7, 2014 | Clauson et al. |
20140277052 | September 18, 2014 | Haselby et al. |
20140352845 | December 4, 2014 | Lev et al. |
20150082746 | March 26, 2015 | Ivosevic et al. |
20150088078 | March 26, 2015 | Lev et al. |
20150112297 | April 23, 2015 | Lev et al. |
20150209232 | July 30, 2015 | Haindl |
20150231034 | August 20, 2015 | Lev |
20150290390 | October 15, 2015 | Ring et al. |
20150297839 | October 22, 2015 | Sanders et al. |
20150305770 | October 29, 2015 | Fill et al. |
20160088995 | March 31, 2016 | Ueda et al. |
20160166824 | June 16, 2016 | Lev et al. |
20160199569 | July 14, 2016 | Yevmenenko et al. |
20160228644 | August 11, 2016 | Cabiri |
20160287475 | October 6, 2016 | Yevmenenko et al. |
20160367439 | December 22, 2016 | Davis et al. |
20180325775 | November 15, 2018 | David |
20190133885 | May 9, 2019 | Wu |
2946559 | October 2015 | CA |
1636605 | July 2005 | CN |
1747683 | March 2006 | CN |
1863566 | November 2006 | CN |
1950049 | April 2007 | CN |
101001661 | July 2007 | CN |
101687083 | March 2010 | CN |
1064693 | September 1959 | DE |
1913926 | September 1970 | DE |
4122476 | January 1993 | DE |
1408498 | May 1995 | DE |
19504413 | August 1996 | DE |
202004012714 | November 2004 | DE |
102007046951 | February 2009 | DE |
202009011019 | December 2010 | DE |
000627237-0001 | January 2007 | EM |
001680703-0002 | March 2010 | EM |
0192661 | September 1986 | EP |
0195018 | September 1986 | EP |
0258913 | March 1988 | EP |
0416454 | March 1991 | EP |
0426403 | May 1991 | EP |
0282545 | February 1992 | EP |
0518397 | December 1992 | EP |
0521460 | January 1993 | EP |
582038 | February 1994 | EP |
0598918 | June 1994 | EP |
0637443 | February 1995 | EP |
0737467 | October 1996 | EP |
761562 | March 1997 | EP |
765652 | April 1997 | EP |
765853 | April 1997 | EP |
0806597 | November 1997 | EP |
0814866 | January 1998 | EP |
829248 | March 1998 | EP |
0856331 | August 1998 | EP |
882441 | December 1998 | EP |
0887085 | December 1998 | EP |
0887885 | December 1998 | EP |
897708 | February 1999 | EP |
0898951 | March 1999 | EP |
960616 | December 1999 | EP |
1008337 | June 2000 | EP |
1029526 | August 2000 | EP |
1034809 | September 2000 | EP |
1051988 | November 2000 | EP |
1323403 | July 2003 | EP |
1329210 | July 2003 | EP |
1396250 | March 2004 | EP |
1454609 | September 2004 | EP |
1454650 | September 2004 | EP |
1498097 | January 2005 | EP |
1872824 | January 2008 | EP |
1911432 | April 2008 | EP |
1919432 | May 2008 | EP |
1930038 | June 2008 | EP |
2090278 | August 2009 | EP |
2351548 | August 2011 | EP |
2351549 | August 2011 | EP |
2462913 | June 2012 | EP |
2512399 | October 2012 | EP |
2029242 | October 1970 | FR |
2856660 | December 2004 | FR |
2869795 | November 2005 | FR |
2931363 | November 2009 | FR |
1444210 | July 1976 | GB |
171662 | October 2005 | IL |
186290 | January 2008 | IL |
03-062426 | September 1991 | JP |
06-050656 | July 1994 | JP |
H08-000710 | January 1996 | JP |
09-104460 | April 1997 | JP |
09-104461 | April 1997 | JP |
10-118158 | May 1998 | JP |
H10-504736 | May 1998 | JP |
11503627 | March 1999 | JP |
11-319031 | November 1999 | JP |
2000-508934 | July 2000 | JP |
2000-237278 | September 2000 | JP |
2000262497 | September 2000 | JP |
2001-505083 | April 2001 | JP |
2002-035140 | February 2002 | JP |
2002-516160 | June 2002 | JP |
2002-355318 | December 2002 | JP |
2003-033441 | February 2003 | JP |
2003-102807 | April 2003 | JP |
2004-501721 | January 2004 | JP |
2004-097253 | April 2004 | JP |
2004-522541 | July 2004 | JP |
2005-270629 | October 2005 | JP |
200661421 | March 2006 | JP |
2008-220961 | September 2008 | JP |
4329954 | September 2009 | JP |
2010063622 | March 2010 | JP |
2010-179128 | August 2010 | JP |
2012-205769 | October 2012 | JP |
2014000220 | January 2014 | JP |
8601712 | March 1986 | WO |
8605683 | October 1986 | WO |
9003536 | April 1990 | WO |
9403373 | February 1994 | WO |
9507066 | March 1995 | WO |
9513785 | May 1995 | WO |
9600053 | January 1996 | WO |
9609083 | March 1996 | WO |
9629113 | September 1996 | WO |
9736636 | October 1997 | WO |
9832411 | July 1998 | WO |
9837854 | September 1998 | WO |
9961093 | December 1999 | WO |
0128490 | April 2001 | WO |
0130425 | May 2001 | WO |
0132524 | May 2001 | WO |
0160311 | August 2001 | WO |
0189607 | November 2001 | WO |
0191693 | December 2001 | WO |
0202165 | January 2002 | WO |
200209797 | February 2002 | WO |
0232372 | April 2002 | WO |
0236191 | May 2002 | WO |
02066100 | August 2002 | WO |
02089900 | November 2002 | WO |
03051423 | June 2003 | WO |
03070147 | August 2003 | WO |
03079956 | October 2003 | WO |
2004041148 | May 2004 | WO |
2004096113 | November 2004 | WO |
2005002492 | January 2005 | WO |
2005018703 | March 2005 | WO |
2005041846 | May 2005 | WO |
2005105014 | November 2005 | WO |
2006099441 | September 2006 | WO |
2007015233 | February 2007 | WO |
2007017868 | February 2007 | WO |
2007052252 | May 2007 | WO |
2007/105221 | September 2007 | WO |
2007101772 | September 2007 | WO |
2008076459 | June 2008 | WO |
2008081424 | July 2008 | WO |
2008126090 | October 2008 | WO |
2009026443 | February 2009 | WO |
2009029010 | March 2009 | WO |
2009038860 | March 2009 | WO |
2009040804 | April 2009 | WO |
2009087572 | July 2009 | WO |
2009093249 | July 2009 | WO |
2009112489 | September 2009 | WO |
2009146088 | December 2009 | WO |
2010061743 | June 2010 | WO |
2010078227 | July 2010 | WO |
2010117580 | October 2010 | WO |
2011/004360 | January 2011 | WO |
2011039747 | April 2011 | WO |
2011058545 | May 2011 | WO |
2011058548 | May 2011 | WO |
2011077434 | June 2011 | WO |
2011090955 | July 2011 | WO |
2011104711 | September 2011 | WO |
2011156373 | December 2011 | WO |
2012/004790 | January 2012 | WO |
2012004784 | January 2012 | WO |
2012063230 | May 2012 | WO |
2012143921 | October 2012 | WO |
2012150587 | November 2012 | WO |
2013127813 | September 2013 | WO |
2013134246 | September 2013 | WO |
2013148435 | October 2013 | WO |
2013156944 | October 2013 | WO |
2013156994 | October 2013 | WO |
2014033706 | March 2014 | WO |
2014033710 | March 2014 | WO |
2014099395 | June 2014 | WO |
2014170888 | October 2014 | WO |
2014174278 | October 2014 | WO |
2016023590 | February 2016 | WO |
2016110838 | July 2016 | WO |
- Summit International Medical Technologies Inc., Vial Direct to Bag Spike 2020.
- Merchant “An engineered control device for needle free reconstitution and transfer of compounded sterile intravenous drug solutions for immediate use to assist in complying with United States Pharmacopeia Chapter <797> standard”, Adv Care, 2 pages, 2018.
- Int'l Search Report and Written opinion dated Jun. 13, 2018 in Int'l Application No. PCT/IL2018/050336.
- Grifols Vial Adapter Product Literature, 2 pages, Jan. 2002.
- Novel Transfer, Mixing and Drug Delivery Systems, MOP Medimop Medical Projects Ltd. Catalog, 4 pages, Rev. 4, 2004.
- Smart Site.RTM. Alaris Medical Systems Product Brochure, 4 pages, Issue 1, Oct. 1999.
- MixJect, downloaded from webpage: http://www.westpharma.com/en/products/Pages/Mixject.aspx, Download Date: Aug. 8, 2012, 1 page.
- MixJet Product Information Sheet, downloaded from webpage: http://www.westpharma.com/SiteCollectionDocuments/Recon/mixject%20product%20sheet.pdf; 1 page.
- Decision to Grant dated Apr. 12, 2010 in EP Application No. 08738307.1.
- The MixJect transfer system, as shown in the article, “Advanced Delivery Devices,” Drug Delivery Technology Jul./Aug. 2007 vol. 7 No. 7 [on-line]. [Retrieved from Internet May 14, 2010.] URL: <http://www.drugdeiverytech-online.com/drugdelivery/200707/?pg=28pg28>. (3 pages).
- Publication date of Israeli Patent Application 186290 [on-line]. ]Retrieved from Internet May 24, 2010]. URL:<http://www.ilpatsearch.justrice.gov.il/UI/RequestsList.aspx>. (1 page).
- Silicone Rubber Overview Downloaded from webpage: http://www.knovel.com/web/portal/browse/display?_EXT_KNOVEL_DISPLAY_bookid=1023&VerticalID=0 on Feb. 9, 2011, Download Date: Sep. 2, 2011, Original Posting Date: 2010, 6 pages.
- Kipp, “Plastic Material Data Sheets,” retrieved from the internet: http://www.knovel.com/web/portal/browse/display?_EXT_KNOVEL_DISPLAY_bookid=1023&VerticalID=0, retrieved on Feb. 9, 2011.
- Alaris Medical Systems Product Brochure, 4 pages, Issue 1, Oct. 11, 1999.
- Smart Site Needle-Free Systems, Alaris Medical Systems Webpage, 4 pages, Feb. 2006.
- Photographs of Alaris Medical Systems SmartSite.RTM. device, 5 pages, 2002.
- Non-Vented Vial Access Pin with ultrasite.rtm. Valve, B. Braun Medical, Inc. website and product description, 3 pages, Feb. 2006.
- IV disposables sets catalogue, Cardinal Health, Alaris® products, SmartSite® access devices and accessories product No. 10013365, SmartSite add-on bag access device with spike adapter and needle-free valve bag access port, pp. 1-5, Fall edition (2007).
- Drug Administration Systems product information sheets; http://www.westpharma.com/eu/en/products/Pages/Vial2Bag.aspx; pp. 1-3 (admitted prior art).
- Article with picture of West Pharmaceutical Services' Vial2Bag Needleless System, [on-line]; ISIPS Newsletter, Oct. 26, 2007]; retrieved from Internet Feb. 16, 2010]; URL:<http://www.isips.org/reports/ISIPS_Newsletter_October_26_2007. html.> (7 pages. see pp. 5-6).
- West, Vial2Bag DC system, Oct. 2, 2014, https://web.archive.org/web/20141002065133/http://www.westpharma.com/en/products/Pages/Reconstitutionsystems.aspx.
- Vial2Bag DC, downloaded from webpage: https://www.youtube.com/watch?v=FEOkglxNBrs, Original posting date: Aug. 21, 2014, 1 page.
- Vial-Mate Adapter Device, Baxter, May 2017, downloaded from web page:http://www.paxtermedicationdeliveryproducts.com/drug-delivery/vialmate.html, Download Date: Jul. 28, 2017, original posting date: unknown, 1page.
Type: Grant
Filed: Mar 23, 2018
Date of Patent: Mar 16, 2021
Patent Publication Number: 20200276084
Assignee: WEST PHARMA. SERVICES IL, LTD. (Ra'anana)
Inventor: Igor Denenburg (Gedera)
Primary Examiner: Benjamin J Klein
Application Number: 16/494,974
International Classification: A61J 1/20 (20060101);