FIELD OF INVENTION The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.
BACKGROUND OF THE INVENTION Follicular neogenesis is defined as the generation of new hair follicles (HF) after birth. Humans are born with a full complement of HF, which can change in size and growth characteristics as in early baldness or can ultimately degenerate and disappear as in late stages of baldness or in permanent scarring (cicatricial) alopecias. Therefore, the generation of new HF is desirable in the treatment of common baldness as well as less common hair loss conditions, such as discoid lupus erythematosis, congenital hypotrichosis, lichen planopilaris and other scarring alopecias.
SUMMARY OF THE INVENTION The present invention provides methods of treating baldness in a subject and generating new hair follicles (HF), comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.
In one embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject.
In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject.
In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle (HF) cell, thereby treating baldness in a scalp, eyebrow, or scarred region.
In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell, thereby treating baldness in a scalp, eyebrow, or scarred region. In another embodiment, the baldness is an androgenetic alopecia (AGA)-induced baldness. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a method for removal of an HF from a skin or scalp of a subject, comprising the steps of: (a) disrupting an epidermis of the skin or scalp: and (b) contacting the skin or scalp with either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) a compound or factor that activates a EGF protein or EGF receptor, thereby removing an HF from a skin or scalp of a subject.
In another embodiment, the present invention provides a method for increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject.
In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of said scalp, eyebrow, or scarred region: and (b) contacting said scalp, eyebrow, or scarred region with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a method for treating an AGA in a scalp, comprising the steps of: (a) disrupting an epidermis of said scalp; and (b) contacting said scalp with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby treating an AGA in a scalp. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.
BRIEF DESCRIPTION OF THE FIGURES FIG. 1: Epidermal abrasion results in de novo hair follicle (HF) formation. HF at progressive stages of development are depicted in the left, center, and right panels. The arrow in the left panel indicates a hair germ. The dark stained cells are progeny of HF stem cells in the bulge.
FIG. 2: BrdU labeling of HF following epidermal abrasion. HF at progressive stages of development are depicted in the left, center, and right panels.
FIG. 3. The wound site did not contain HF immediately after re-epithelialization. Top view (left panel) and tissue section (right panel) of the site 10 days after wound induction.
FIG. 4. Appearance of hair germs 12 days after wound induction. Arrow indicates hair germ.
FIG. 5. Epidermal Disruption-Induced HF neogenesis (EDIHN)-induced hair germs express K17. Two different hair germs are depicted in the left and right panels.
FIG. 6. EDIHN-induced hair germs contain dermal papilla (DP) cells, as evidenced by alkaline phosphatase (AP) staining. Arrows indicate DP cells. Left panel: hair germs. Right panel: HF at a further developmental stage.
FIG. 7. Histological comparison between EDIHN-induced and embryonic HF. Top left, second from left, third from left, and right panels: Progressive stages of EDIHN-induced HF development. Bottom left, center, and right panels: Progressive stages of and embryonic HF development.
FIG. 8. Induction of several markers of embryonic HF development, Lef1 (left panel), wingless/int (Wnt) 10b (center panel), and sonic hedgehog (Shh; right panel), by EDIHN. HF structures are indicated by arrowheads.
FIG. 9. Proliferative activity during EDIHN, as evidenced by BrdU pulse-labeling. Progressive stages of HF development are depicted in the left, center, and right panels.
FIG. 10. Induction of HF markers S100A3 (left panel; tissue section parallel to HF axis) and S100A6 (right panel; cross-sectional view of follicle) by EDIHN.
FIG. 11. New hair growth 25 days (left panel) and 45 days (right panel) after wound induction.
FIG. 12. Schematic of whole-mount EDIHN assay.
FIG. 13. Repopulation of stem cells in the bulge of EDIHN-induced HF, as evidenced by retention of BrdU label following a chase period. Left panel: lower magnification: 50×. Right panel: higher magnification: 400×.
FIG. 14. FIG. 14A. Stem cells in EDIHN-induced HF express K15. Left top panel: Top view of wound site. Bottom, far left panel: epidermis whole mount; bottom, second from left panel: same as [bottom, far left] panel but viewed under white light; right panel: tissue sections. FIG. 14B. Neogenesis HF proceed to next hair cycle.
FIG. 15. Schematic of creation of new HF by EDIHN.
FIG. 16. No new HF are evident 11 days after wound induction in 21-day-old mice. Top panel: macroscopic examination: bottom left panel: AP staining of the dermis; bottom right panel: K17 staining of the epidermis.
FIG. 17. 14 days after wound induction, new HF have begun to form as evidenced by AP staining of the dermis (left panel) and K17 staining of the epidermis (right panel). Main panels: 10× magnification. Inserts: 80× magnification.
FIG. 18. 17 days after wound induction, new HF are more developed. Left panel: AP staining of the dermis; right panel: K17 staining of the epidermis. Main panels: 10× magnification. Inserts: 80× magnification.
FIG. 19. Wounds closed similar in mice subjected to depilation, then wounding (left 3 mice in each panel) vs. wounding alone (right 4 mice in each panel). Left panel: immediately following wounding. Right panel: 10 days following wounding.
FIG. 20. Anagen induction by depilation prior to wounding enhances the efficiency of EDIHN. A. Top panel: lower left panel AP staining of the dermis; lower right panel: K17 staining of the epidermis. B. Graphical representation of enhancement of EDIHN by depilation.
FIG. 21. FIG. 21A. EDIHN in human skin grafted to immunodeficient (scid) mice, seven days after induction of an excisional wound. Arrows indicate new HF. FIG. 21B. Dermal abrasion of human skin grafts results in EDIHN. Human adult skin (W) was grafted onto mice, abraded, and examined seven days later, by staining for S100A6 (first, second, and fourth rows) or S100A4 (third row). Hair germs (HG) and dermal papilla (DP) are indicated. Human fetal skin (F) with normal developing hair follicles is shown for comparison. Mouse skin 17d post wounding was included as a control (top left panel).
FIG. 22. Transcripts up-regulated at least 2-fold in activated HF cells, as assessed by dChip analysis. (FIG. 22A). Mean values and standard errors of the up-regulated transcripts in non-activated (“bs-line”) and activated (“expt”) samples and fold-changes and differences between non-activated and activated values are depicted. (FIG. 22B). Raw data for up-regulated transcripts in non-activated and activated cells. “Ctrl” denotes non-activated and “High-dep” denotes activated cells. (FIG. 22C). Additional information about up-regulated transcripts.
FIG. 23. Pigmented hair follicle neogenesis observed in the skin of Dkk1-expressing mice following EDIHN FIG. 23A. 3.2× magnification. FIG. 23B. 8× magnification.
FIG. 24. Control mice lacked pigmented HF.
FIG. 25. EGF inhibits HF formation by EDIHN. FIG. 25A. K17 staining of wounded skin of representative mouse treated with EGF. Magnification is 4×. FIG. 25B. High magnification view (10×) of skin depicted in (FIG. 25A). FIG. 25C. K17 staining of wounded skin of representative control mouse that received no EGF after wounding. Magnification is 4×. FIG. 25D. Higher magnification view (10×) of skin depicted in (FIG. 25D).
FIG. 26. Administration of an EGF receptor inhibitor (AG1478) leads to generation of more and larger HF compared with controls. FIG. 26A. Top: skin of 2 control mice. Outer dashed line indicates the extent of the wounded area after contraction and healing; inner dashed line indicates the area of neogenesis. Bottom: skin of 2 treated mice, in which the wounded area and area of neogenesis largely coincide, with the exception of a small area on the left side of the encircled area in each panel. FIG. 26B. Large hair follicles developed in the wounded area in the AG1478-injected mice. Left panel: epidermis stained for K17, with three large hair follicles next to each other. Right panel: dermis stained for AP with large coalescing DP areas. Scale Bars: 200 μm.
FIG. 27. FIG. 27A. Increased hair follicle formation in K14-Wnt7a mice. Left panel: Wnt7a transgenic mice. Right panel: control (wild-type) mice. FIG. 27B. Quantiation of experiment with 4 week old mice. FIG. 27C. Quantiation of experiment with 3 week old mice
DETAILED DESCRIPTION OF THE INVENTION The present invention provides methods of treating baldness in a subject and generating new HF, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.
In one embodiment, the present invention provides a method for generating a hair follicle (HF) in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby generating an HF in a scalp, eyebrow, or scarred region of a subject.
In another embodiment, the present invention provides a method for generating an HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby generating an HF in a scalp, eyebrow, or scarred region of a subject.
In another embodiment, the present invention provides a method for generating a new IF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby generating a new HF in a scalp, eyebrow, or scarred region of a subject.
In another embodiment, the present invention provides a method for increasing the number of HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby increasing the number of HF in a scalp, eyebrow, or scarred region of a subject.
In another embodiment, the present invention provides a use of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, for the preparation of a pharmaceutical composition for use in a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the compound or factor.
In another embodiment, the present invention provides a use of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the compound or factor.
In another embodiment, the present invention provides a use of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, for the preparation of a pharmaceutical composition for use in a method for treating AGA in a scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp with the compound or factor.
In another embodiment, the present invention provides a method for increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject. In another embodiment, the factor is an inhibitor of an EGF protein or an EGFR. In another embodiment, the factor is a Hedgehog protein, a nucleotide encoding same or an activator of same. In another embodiment, the factor is an androgen antagonist. In another embodiment, the factor is any other compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of said scalp, eyebrow, or scarred region: and (b) contacting said scalp, eyebrow, or scarred region with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.
The precursor cell of methods and compositions of the present invention, is, in another embodiment, a HF stem cell. In another embodiment, the precursor cell is an epidermal cell. In another embodiment, the precursor cell is a dermal papilla cell. In another embodiment, the precursor cell is a connective tissue sheath cell. In another embodiment, the precursor cell is any other type of cell known in the art that is capable of differentiation into a hair follicle cell. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of said scalp, eyebrow, or scarred region; and (b) contacting said scalp, eyebrow, or scarred region with a precursor cell that is capable of differentiation into a hair follicle cell, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject.
In another embodiment, the present invention provides a method for treating an AGA in a scalp, comprising the steps of: (a) disrupting an epidermis of said scalp; and (b) contacting said scalp with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby treating an AGA in a scalp. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a method for treating an AGA in a scalp, comprising the steps of: (a) disrupting an epidermis of said scalp; and (b) contacting said scalp with a precursor cell that is capable of differentiation into a hair follicle cell, thereby treating an AGA in a scalp.
In another embodiment, the inductive cell is a mesenchymal cell. In another embodiment, the inductive cell is any other type of inductive cell enumerated herein. In another embodiment, the inductive cell is any other type of inductive cell known in the art. Each possibility represents a separate embodiment of the present invention.
“Contacting” as used herein refers, in another embodiment, to bringing the scalp, eyebrow, etc, into to contact with the compound, factor, cell, etc. In another embodiment, the term refers to embedding the compound, factor, cell, etc into the scalp, eyebrow, etc. In another embodiment, the term refers to injecting the compound, factor, cell, etc into the scalp, eyebrow, etc. In another embodiment, term refers to any other type of contacting known in the art. Each possibility represents a separate embodiment of the present invention.
“Promotes a differentiation” refers, in another embodiment, to the act of increasing the percentage of cells that will differentiate as indicated. In another embodiment, the term refers to increasing the number of cells per unit area of skin that will differentiate. In another embodiment, the promoter of differentiation is active in the milieu of the skin. Each possibility represents a separate embodiment of the present invention.
“Uncommitted epidermal cell” refers, in another embodiment, to an epidermal stem cell. In another embodiment, the epidermal cell is a bulge cell. In another embodiment, the epidermal cell is a bulge-derived cell. In another embodiment, the epidermal cell is any other type of cell known in the art that can be induced to differentiate into an HF cell.
The “HF cell” that results from the differentiation is, in another embodiment, an HF stem cell. In another embodiment, the HF cell is a dermal papilla cell. In another embodiment, the HF cell is a bulb cell. In another embodiment, the HF cell is a matrix cell. In another embodiment, the HF cell is a hair shaft cell. In another embodiment, the HF cell is an inner root sheath cell. In another embodiment, the HF cell is an outer root sheath cell. In another embodiment, the HF cell is a melanocyte stem cell. In another embodiment, the HF cell is a melanocyte. Each type of uncommitted epidermal cell and HF cell represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle (HF) cell, thereby treating baldness in a scalp, eyebrow, or scarred region. In another embodiment, the baldness is an androgenetic alopecia (AGA)-induced baldness. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell, thereby treating baldness in a scalp, eyebrow, or scarred region. In another embodiment, the baldness is an androgenetic alopecia (AGA)-induced baldness. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is administed in a solution. In another embodiment, the compound or factor is administed in a cream. In another embodiment, the compound or factor is administed in an ointment. In another embodiment, the compound or factor is administed in a slow release formulation. In another embodiment, the compound or factor is administed in a liposome encapsulated formulation. In another embodiment, the compound or factor is directly injected. In another embodiment, the compound or factor is administed by any other method known in the art. Each possibility represents a separate embodiment of the present invention.
The compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is, in another embodiment, an inhibitor of an Epidermal Growth Factor (EGF). In another embodiment, the compound or factor is an inhibitor of an EGF receptor. Each possibility represents a separate embodiment of the present invention.
As provided herein (Example 11), activating one or more pathways in which EGF is involved (by injection of EGF) blocks the formation of HF. Thus, antagonizing the pathway increases HF formation, as demonstrated in Example 12.
In another embodiment, the inhibitor of an EGF or an EGF receptor is panitumumab. In another embodiment, the inhibitor is AG1478. In another embodiment, the inhibitor is nimotuzumab. In another embodiment, the inhibitor is an antibody that binds EGF or EGFR. In another embodiment, the inhibitor is HuMax-EGFR® (Genmab, Copenhagen, Denmark). In another embodiment, the inhibitor is cetuximab. In another embodiment, the inhibitor is IMC 11F8. In another embodiment, the inhibitor is matuzumab. In another embodiment, the inhibitor is SC 100. In another embodiment, the inhibitor is ALT 110. In another embodiment, the inhibitor is PX 1032. In another embodiment, the inhibitor is BMS 599626. In another embodiment, the inhibitor is MDX 214. In another embodiment, the inhibitor is PX 1041. In another embodiment, the inhibitor is any other inhibitor of an EGF or an EGF receptor known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is an inhibitor of a tyrosine kinase activity of an EGF receptor. In another embodiment, the inhibitor is gefitinib. In another embodiment, the inhibitor is erlotinib. In another embodiment, the inhibitor is canertinib. In another embodiment, the inhibitor is leflunomide. In another embodiment, the inhibitor is A77 1726. In another embodiment, the inhibitor is pelitinib. In another embodiment, the inhibitor is ZD 1839. In another embodiment, the inhibitor is CL 387785. In another embodiment, the inhibitor is EKI 785. In another embodiment, the inhibitor is vandetanib. In another embodiment, the inhibitor is any other inhibitor of a tyrosine kinase activity of an EGF receptor known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the EGF or EGFR antagonist is a carboxypeptidase inhibitor from potato (PCI) protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is a sprouty protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is an Argos protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is a lefty protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is an antibody that recognizes EGF or EGFR, or a fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is small molecule inhibitor that binds and reduces the activity of EGF or EGFR. In another embodiment, the EGF or EGFR antagonist is CRM197. In another embodiment, the EGF or EGFR antagonist is IMC-C225 (ImClone Systems, New York, N.Y.). In another embodiment, the EGF or EGFR antagonist is any other antagonist of EGF or EGFR known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a use of an inhibitor of an EGF protein or an EGF receptor for the preparation of a pharmaceutical composition for use in a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the inhibitor of an EGF protein or an EGF receptor.
In another embodiment, the present invention provides a use of an inhibitor of an EGF protein or an EGF receptor for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the inhibitor of an EGF protein or an EGF receptor.
In another embodiment, the present invention provides a use of an inhibitor of an EGF protein or an EGF receptor for the preparation of a pharmaceutical composition for use in a method for treating AGA in a scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp with the inhibitor of an EGF protein or an EGF receptor.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a β-catenin protein. In another embodiment, the compound or factor is a nucleotide that encodes a β-catenin protein. In another embodiment, the compound or factor is an activator of a β-catenin protein. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the β-catenin protein. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a use of (a) a β-catenin protein; (b) a nucleotide encoding a β-catenin protein; or (c) a compound or factor that activates a β-catenin protein, for the preparation of a pharmaceutical composition for use in a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the β-catenin protein, nucleotide, compound or factor.
In another embodiment, the present invention provides a use of (a) a β-catenin protein; (b) a nucleotide encoding a β-catenin protein; or (c) a compound or factor that activates a β-catenin protein, for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the β-catenin protein, nucleotide, compound or factor.
In another embodiment, the present invention provides a use of (a) a β-catenin protein; (b) a nucleotide encoding a β-catenin protein; or (c) a compound or factor that activates a β-catenin protein, for the preparation of a pharmaceutical composition for use in a method for treating AGA in a scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp with the β-catenin protein, nucleotide, compound or factor.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a fibroblast growth factor (FGF) protein. In another embodiment, the compound or factor is a nucleotide that encodes an FGF protein. In another embodiment, the compound or factor is an FGF receptor. In another embodiment, the compound or factor is a nucleotide that encodes an FGF receptor. In another embodiment, the compound or factor is an activator of an FGF protein. In another embodiment, the compound or factor is an activator of FGF receptor. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the FGF protein or FGF receptor. In another embodiment, the protein that is inhibited is an FGF binding protein. In another embodiment, the protein that is inhibited is FGF-bp1. Each possibility represents a separate embodiment of the present invention.
Is provided herein, FGF and its receptor are upregulated, under the conditions utilized herein, upon HF stem cell differentiation (Example 9). Moreover, FGF-bp1 is downregulated, under the conditions utilized herein, upon HF stem cell differentiation. Thus, FGF and its receptor promote differentiation of uncommitted epidermal cells into HF cells.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is an ectodysplasin protein (referred to, in another embodiment, as “eda”; in another embodiment, as “ectodermodysplasin protein.”) In another embodiment, the ectodysplasin protein is Eda-A1. In another embodiment, the compound or factor is an ectodysplasin receptor (referred to, in another embodiment, as “edar”). In another embodiment, the compound or factor is an activator of an ectodysplasin protein. In another embodiment, the compound or factor is an activator of an ectodysplasin receptor. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the ectodysplasin protein or ectodysplasin receptor. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the eda protein of methods and compositions of the present invention has the sequence: MGYPEVERRELLPAAAPRERGSQGCGCGGAPARAGEGNSCLLFLGFFGLSLALHLLTLCC YLELRSELRRERGAESRLGGSGTPGTSGTLSSLGGLDPDSPITSHLGQPSPKQQPLEPGEAA LHSDSQDGHQMALLNFFFPDEKPYSEEESRRVRRNKRSKSNEGADGPVKNKKKGKKAGP PGPNGPPGPPGPPGPQGPPGIPGIPGIPGTTVMGPPGPPGPPGPQGPPGLQGPSGAADKAGTR ENQPAVVHLQGQGSAIQVKNDLSGGVLNDWSRITMNPKVFKLHPRSGELEVLVDGTYFIY SQVEVYYINFTDFASYEVVVDEKPFLQCTRSIETGKTNYNTCYTAGVCLLKARQKIAVKM VHADISINMSKHTTFFGAIRLGEAPAS (GenBank Accession No: NM_001399; SEQ ID No: 274). In another embodiment, the eda protein has a sequence selected from the sequences set forth in GenBank entries NM_001005609, NM_001005610, NM_001005611, NM_001005612, NM_001005613, NM_001005614, NM_001005615, AF040628, AF061194, AF061193, AF061192, AF061191, AF061190, AF061189, and AF060999. In another embodiment, the eda protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an Eda protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the edar protein of methods and compositions of the present invention has the sequence: MAIVGDCTQTPWLPVLVVSLMCSARAEYSNCGENEYYNQTTGLCQECPPCGPGEEPYLS CGYGTKDEDYGCVPCPAEKFSKGGYQICRRIHKDCEGFFRATVLTPGDMENDAECGPCLP GYYMLENRPRNIYGMVCYSCLLAPPNTKECVGATSGASANFPGTSGSSTLSPFQHAIIKEL SGQGHLATALIIAMSTIFIMAIAIVLIIMFYILKTKPSAPACCTSHPGKSVEAQVSKDEEKKE APDNVVMFSEKDEFEKLTATPAKPTKSENDASSENEQLLSRSVDSDEEPAPDKQGSPELCL LSLVIILAREKSATSNKSAGIQSRRKKILDVYANVCGVVEGLSPTELPFDCLEKTSRMLSST YNSEKAVVKTWRHLAESFGLKRDEIGGMTDGMQLFDRISTAGYSIPELLTKLVQIERLDA VESLCADILEWAGVVPPASQPHAAS (GenBank Accession No: BC093872; SEQ ID No: 275). In another embodiment, the edar protein has a sequence selected from the sequences set forth in GenBank entries BC093870; BC034919; NM_021783; NM_022336; AY152724; AF298812; AH008077; AF130996; AF130988. In another embodiment, the edar protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an Edar protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a Noggin protein. In another embodiment, the compound or factor is a nucleotide encoding a Noggin protein. In another embodiment, the compound or factor is an activator of a Noggin protein. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the Noggin protein. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the Noggin protein of methods and compositions of the present invention has the sequence: MERCPSLGVTLYALVVVLGLRATPAGGQHYLHIRPAPSDNLPLVDLIEHPDPIFDPKEKDLN ETLLRSLLGGHYDPGFMATSPPEDRPGGGGGAAGGAEDLAELDQLLRQRPSGAMPSEIKGL EFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKR SCSVPEGMVCKPSKSVHLTVLRWRCQRRGGQRCGWIPIQYPIISECKCSC (GenBank Accession No: NM_005450; SEQ ID No: 276). In another embodiment, the Noggin protein has a sequence selected from the sequences set forth in GenBank entries BC034027 and U31202. In another embodiment, the Noggin protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of a Noggin protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a Hedgehog protein. In another embodiment, the compound or factor is a nucleotide encoding a Hedgehog protein. In another embodiment, the compound or factor is an activator of a Hedgehog protein. In another embodiment, the compound or factor is a sonic Hedgehog protein. In another embodiment, the compound or factor is a nucleotide encoding a sonic Hedgehog protein. In another embodiment, the compound or factor is an activator of a sonic Hedgehog protein. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the Hedgehog protein of methods and compositions of the present invention has the sequence set forth in GenBank Accession No. NM_000193. In another embodiment, the Hedgehog protein has a sequence selected from those set forth in GenBank entries L38518 and NP_000184. In another embodiment, the Hedgehog protein has any other Hedgehog sequence known in the art. In another embodiment, the Hedgehog protein has any other sonic Hedgehog sequence known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a Transforming Growth Factor (TGF)-beta1 protein. In another embodiment, the compound or factor is a nucleotide encoding a TGF-beta1 protein. In another embodiment, the compound or factor is an activator of a TGF-beta1 protein. In another embodiment, the compound or factor is a TGF-beta3 protein. In another embodiment, the compound or factor is a nucleotide encoding a TGF-beta3 protein. In another embodiment, the compound or factor is an activator of a TGF-beta3 protein. In another embodiment, the compound or factor is an antagonist of a TGF-beta1 protein. In another embodiment, the compound or factor is an antagonist of a TGF-beta3 protein. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the TGF-beta1 protein of methods and compositions of the present invention has the sequence set forth in GenBank Accession No. BC000125. In another embodiment, the Hedgehog protein has a sequence selected from those set forth in GenBank entries BC001180, BC022242, and NM_000660. In another embodiment, the TGF-beta1 protein has any other TGF-beta1 sequence known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the TGF-beta3 protein of methods and compositions of the present invention has the sequence set forth in GenBank Accession No. J03241. In another embodiment, the Hedgehog protein has a sequence selected from those set forth in GenBank entries NM_003239, BC018503, BT007287 and X14149. In another embodiment, the TGF-beta3 protein has any other TGF-beta3 sequence known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell acts directly on the uncommitted epidermal cell. In another embodiment, the compound or factor acts on the uncommitted epidermal cell via a mesenchymal cell. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the mesenchymal cell is a dermal condensate cell. In another embodiment, the mesenchymal cell is a DP cell. In another embodiment, the mesenchymal cell is another cell type or differentiation stage in the dermal condensate-DP lineage. In another embodiment, the mesenchymal cell is any other type of mesenchymal cell known in the art. Each possibility represents a separate embodiment of the present invention.
The EGFR of methods and compositions of the present invention has, in another embodiment, the sequence: MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVL SNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQN HLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTG PRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVV TDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKN CTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEI IRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQK TKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPRE FVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVW KYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFM RRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGL WIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQL MPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH VKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMT FGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMAR DPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPL LSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSV PKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHW AQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA (GenBank Accession No: NM_005228; SEQ ID No: 277). In another embodiment, the EGFR has a sequence selected from the sequences set forth in GenBank entries NM_201282, NM_201283, NM_201284, BC094761, AF288738, AY588246, AY573061, X17054, AF125253, U48722, K03193, and AY698024. In another embodiment, the EGFR is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an EGFR is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.
The EGF of methods and compositions of the present invention has, in another embodiment, the sequence: MLLTLIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGT NYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAIN WINEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRAD LDGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHN LFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDD TWEPEQKLCKLRKGNCSSTVCGQDLQSHILCMCAEGYALSRDRKYCEDVNECAFWNHGCT LGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLE RDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQ DIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIE EGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLF WTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKR RRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVRLQGSMLKPSSLVVVH PLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEV DLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATC QCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDEC QLGVHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPL SHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELRHAGHGQQQKVIVV AVCVVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYEESSRDVRSRRPADTEDGMSSCPQP WFVVIKEHQDLKNGGQPVAGEDGQAADGSMQPTSWRQEPQLCGMGTEQGCWIPVSSDKG SCPQVMERSFHMPSYGTQTLEGGVEKPHSLLSANPLWQQRALDPPHQMELTQ (GenBank Accession No: NM_001963; SEQ ID No: 278). In another embodiment, the EGF has a sequence selected from the sequences set forth in GenBank entries BC093731, AY548762, and X04571. In another embodiment, the EGF is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an EGF is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.
The beta-catenin protein of methods and compositions of the present invention has, in another embodiment, the sequence: MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDT SQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHP TNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQL SKKEASRIIAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLIINLSHIIREGLLAIFKSGGIPA LVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTD CLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAG GMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCA AGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEM AQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLV RAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQL LYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMS EDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGY GQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL (GenBank Accession No: NM_001904; SEQ ID No: 279). In another embodiment, the beta-catenin protein has a sequence selected from the sequences set forth in GenBank entries BC058926, X87838, AF130085, AB062292, Z19054, and NP_001895. In another embodiment, the beta-catenin protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of a beta-catenin protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.
The Wnt protein of methods and compositions of the present invention has, in another embodiment, the sequence: MNRKARRCLGHLFLSLGMVYLRIGGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAIIVIGE GSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAACT QGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLH NNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRA SRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASGC DLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK (GenBank Accession No: BC008811; SEQ ID No: 280). In another embodiment, the Wnt protein has a sequence selected from the sequences set forth in GenBank entries NM_004625, D83175, U53476, and NP_004616. In another embodiment, the Wnt protein is a Wnt7 protein. In another embodiment, the Wnt protein is a Wnt7a protein. In another embodiment, the Wnt protein is Wnt1 protein. In another embodiment, the Wnt protein is a Wnt3 protein. In another embodiment, the Wnt protein is a Wnt3a protein. In another embodiment, the Wnt protein is a Wnt10 protein. In another embodiment, the Wnt protein is a Wnt10a protein. In another embodiment, the Wnt protein is a Wnt10b protein. In another embodiment, the Wnt protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of a Wnt protein is utilized in a method of the present invention. In another embodiment, a biologically active fragment of a Wnt7 protein is utilized in a method of the present invention. In another embodiment, a biologically active fragment of a Wnt7a protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a protein encoded by a ribonucleic acid (RNA) molecule having a sequence selected from the sequences set forth in SEQ ID No: 1-232. In another embodiment, the compound or factor is an RNA molecule having a sequence selected from SEQ ID No: 1-232. In another embodiment, the RNA molecule is homologous to a sequence selected from SEQ ID No: 1-232. In another embodiment, the RNA molecule is an isoform of a sequence selected from SEQ ID No: 1-232. In another embodiment, the compound or factor increases an activity of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 1-232. In another embodiment, the compound or factor increases an expression or level of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 1-232. Each possibility represents a separate embodiment of the present invention.
As provided herein, the transcripts depicted in Table 3 (Example 8; SEQ ID No: 1-232), the proteins they encode, and the pathways in which the proteins participate contribute significantly to HF stem cell activation. Accordingly, under the conditions utilized herein, anagen can be induced by activation of these transcripts, proteins, and pathways. Activation of the transcripts, proteins, and pathways depicted in Table 3 is thus a method for enhancing EDIHN. In another embodiment, activation of these transcripts, proteins, and pathways represents a method for enhancing hair growth in a subject.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 233-257. In another embodiment, the compound or factor is an RNA molecule having a sequence selected from SEQ ID No: 233-257. In another embodiment, the RNA molecule is homologous to a sequence selected from SEQ ID No: 233-257. In another embodiment, the RNA molecule is an isoform of a sequence selected from SEQ ID No: 233-257. In another embodiment, the compound or factor increases an activity of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 233-257. In another embodiment, the compound or factor increases an expression or level of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 233-257. Each possibility represents a separate embodiment of the present invention.
As provided herein, the transcripts depicted in Table 4 (Example 9; SEQ ID No: 233-257), the proteins they encode, and the pathways in which the proteins participate, contribute significantly, under the conditions utilized herein, to induction of epidermal cells to differentiate into HF stem cells. Activation of the transcripts, proteins, and pathways depicted in Table 4 is thus a method for enhancing EDIHN. In another embodiment, activation of these transcripts, proteins, and pathways represents a method for enhancing hair growth in a subject.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a compound or factor that decreases an activity of a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 258-273. In another embodiment, the compound or factor decreases an expression or level of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 258-273. Each possibility represents a separate embodiment of the present invention.
As demonstrated by findings of the present invention, the transcripts depicted in Table 5 (Example 9; SEQ ID No: 258-273), the proteins they encode, and the pathways in which the proteins participate, contribute significantly, under the conditions utilized herein, to preventing induction of epidermal cells to differentiate into HF stem cells. Inhibition of the transcripts, proteins, and pathways depicted in Table 5 is thus a method for enhancing EDIHN. In another embodiment, inhibition of these transcripts, proteins, and pathways represents a method for induction of hair growth in a subject.
In one embodiment, the compound that modulates a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 233-273 or the nucleic acid encoding same is administered before the compound that modulates a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 1-232 or the nucleic acid encoding same. In another embodiment, the two compounds are administered simultaneously. Each possibility represents a separate embodiment of the present invention.
In one embodiment, a protein encoded by an RNA sequence selected from SEQ ID No: 1-273, or a compound that modulates the protein, is administered before other proteins encoded by same or compounds that modulate them, in order to further enhance their effect in generating an HF or stimulating hair growth. In another embodiment, the wnt pathway is stimulated before the hedgehog pathway. In another embodiment, the two pathways are stimulated in an overlapping fashion. In another embodiment, the two pathways are stimulated simultaneously. Each possibility represents a separate embodiment of the present invention.
In another embodiment, activating or decreasing expression of an RNA transcript in methods of the present invention occurs via a transcription mechanism (e.g. activation of expression of the RNA). In another embodiment, activating or decreasing expression of the RNA transcript occurs via a translational mechanism. In another embodiment, activating or decreasing expression of the RNA transcript occurs via a post-translational mechanism. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the nucleic acid molecule utilized in methods of the present invention is a deoxyribonucleic acid (DNA) molecule that encodes an RNA molecule having a sequence selected from the sequences set forth in the present invention.
In one embodiment, an RNA molecule of the present invention encodes a protein that plays a role in HF regeneration. In another embodiment, the RNA molecule is itself catalytically active, e.g., a ribozyme, etc. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a compound or factor that promotes placodal cell fate. As provided herein, factors that promote placodal cell fate enhance EDIHN, as exemplified in the Examples herein. In another embodiment, the compound or factor acts at the placode stage of HF development.
In another embodiment, the compound or factor inhibits a biological factor that inhibits a differentiation of an uncommitted epithelial cell into an HF cell.
In another embodiment of methods and compositions of the present invention, a composition comprising one of the above compounds or factors is administered. Each of the above types of compounds, factors, and compositions represents a separate embodiment of the present invention.
In one embodiment, the present invention provides a method for generating an HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with minoxidil, thereby generating an HF in a scalp, eyebrow, or scarred region of a subject.
In one embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with minoxidil, thereby treating baldness in a scalp, eyebrow, or scarred region of a subject.
In another embodiment, the present invention provides a use of minoxidil for the preparation of a pharmaceutical composition for use in a method for an HF in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the minoxidil.
In another embodiment, the present invention provides a use of minoxidil for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the minoxidil.
In another embodiment, the present invention provides a method for removal of an HF from a skin or scalp of a subject, comprising the steps of: (a) disrupting an epidermis of the skin or scalp; and (b) contacting the skin or scalp with either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor: or (iv) a compound or factor that activates a EGF protein or EGF receptor, thereby removing an HF from a skin or scalp of a subject.
In another embodiment, the present invention provides a method for hair removal from a skin or scalp of a subject, comprising the steps of: (a) disrupting an epidermis of the skin or scalp: and (b) contacting the skin or scalp with either: (i) an EGF protein: (ii) an EGF receptor, (iii) a nucleotide encoding an EGF protein or EGF receptor: or (iv) a compound or factor that activates a EGF protein or EGF receptor, thereby removing hair from a skin or scalp of a subject. In another embodiment, the epidermal disruption is light dermabrasion. In another embodiment, the epidermal disruption is a non-scarring method. In another embodiment, administration of the EGF protein, EGF receptor, nucleotide, compound, or factor suppresses HF formation. In another embodiment, the EGF protein, EGF receptor, nucleotide, compound, or factor is administered within several days of healing. In another embodiment, the EGF protein, EGF receptor, nucleotide, compound, or factor is administered within about 1 day of healing. In another embodiment, the EGF protein, EGF receptor, nucleotide, compound, or factor is administered according to any of the timing embodiments enumerated herein for Dkk1 protein. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a use of either: (i) an EGF protein; (ii) an EGF receptor: (iii) a nucleotide encoding an EGF protein or EGF receptor: or (iv) a compound or factor that activates a EGF protein or EGF receptor, for the preparation of a pharmaceutical composition for use in a method for removal of an HF from a skin or scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the EGF protein, EGF receptor, nucleotide, compound, or factor.
In another embodiment, a composition or method of the present invention is utilized on human skin. In another embodiment, the composition or method is utilized on an area of unwanted hair growth. In another embodiment, the area is the face. In another embodiment, the area is the bikini area. In another embodiment, the area is the legs. In another embodiment, the area is the arms. In another embodiment, the area is the chest.
An “inhibitor” utilized in methods and compositions of the present invention is, in another embodiment, an antibody that binds the protein or biological factor that is the target of the inhibitor. In another embodiment, the inhibitor is a pharmacologic inhibitor. In another embodiment, the inhibitor is any other type of inhibitor known in the art. Each possibility represents a separate embodiment of the present invention.
The step of disrupting the epidermis in methods of the present invention is performed, in another embodiment, by abrading the scalp, eyebrow, or scarred region. In another embodiment, the term “abrading” refers to an act of creating an abrasion. In another embodiment, “abrading” refers to rubbing. In another embodiment, “abrading” refers to wearing away by friction. As provided herein (Example 1), epidermal abrasion causes, under the conditions utilized herein, de novo HF neo-genesis. In another embodiment, the epidermal layer is disrupted.
In one embodiment, “abrasion” has the same meaning as “abrading.” In another embodiment. “abrasion” refers to an area of the scalp or skin from which the epidermis is removed. In another embodiment, “abrasion” refers to an area of the scalp or skin from which the epidermis and dermis are removed. Each definition of “abrading” and “abrasion” represents a separate embodiment of the present invention.
As provided herein, under the conditions utilized, epidermal disruption by a method of the present invention converts the skin back, in another embodiment, to an embryonic-like state, in which the follicle regenerates. In another embodiment, a subsequent window of opportunity is created, during which the number and size of new HF in the skin can be manipulated. In another embodiment, the administration of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell during this window causes regeneration of larger and more numerous HF. The morphology of HF in abraded skin is similar to that of embryonic HF (Example 1-2 and subsequent Examples), and the markers expressed are similar as well.
In another embodiment, the present invention provides a method of stimulating hair growth in a scalp, eyebrow, or scarred region of a subject, comprising performing a method of present invention, thereby stimulating hair growth in a scalp, eyebrow, or scarred region of a subject. As demonstrated in Example 3, EDIHN-induced HF are capable of generating hairs. Thus, methods of the present invention can be used to stimulate hair growth.
“EDIHN,” in another embodiment, refers to HF neogenesis induced by disruption of the epithelial layer. In another embodiment, the term refers to HF neogenesis induced by abrasion. In another embodiment, the term refers to HF neogenesis induced by wounding. In another embodiment, the term refers to HF neogenesis induced by disruption of the epithelial layer, followed by administration of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a method of testing an ability of a compound to modulate HF generation in vivo, comprising (a) disrupting an epithelial layer of a first scalp, eyebrow, or scarred region, whereby the first scalp, eyebrow, or scarred region has been contacted with the compound; (b) measuring a first HF generation in the first scalp, eyebrow, or scarred region; (c) disrupting an epithelial layer of a second scalp, eyebrow, or scarred region, wherein the second scalp, eyebrow, or scarred region is a scalp, eyebrow, or scarred region of the first subject or a second subject, whereby the second scalp, eyebrow, or scarred region has not been contacted with the compound; (d) measuring a second HF generation in the second scalp, eyebrow, or scarred region; and (e) comparing the first HF generation to the second HF generation, whereby a difference between the first HF generation and the second HF generation indicates that the compound modulates an HF generation in vivo (Examples).
In another embodiment, the present invention provides a method of testing an ability of a compound to stimulate hair growth in vivo, comprising disrupting an epithelial layer of a first scalp, eyebrow, or scarred region, whereby the first scalp, eyebrow, or scarred region has been contacted with the compound; measuring a first HF generation in the first scalp, eyebrow, or scarred region; disrupting an epithelial layer of a second scalp, eyebrow, or scarred region, whereby the second scalp, eyebrow, or scarred region has not been contacted with the compound; measuring a second HF generation in the second scalp, eyebrow, or scarred region; and comparing the first HF generation to the second HF generation, whereby a difference between the first HF generation and the second HF generation indicates that the compound stimulates a hair growth in vivo.
In one embodiment, the methods of the present invention of testing a compound are repeated using a plurality of subjects, until a statistically significant sample has been tested.
In another embodiment of methods for testing compounds of the present invention, the first scalp, eyebrow, or scarred region is a scalp, eyebrow, or scarred region of a first subject. In another embodiment, the subject is a subject in need of generation of a new HF. The second scalp, eyebrow, or scarred region, in another embodiment, is a scalp, eyebrow, or scarred region of the first subject. In another embodiment, the second scalp, eyebrow, or scarred region is a scalp, eyebrow, or scarred region of a second subject. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the excisional wounds of methods of the present invention are created using a surgical tool. In one embodiment, the surgical tool is a dermal biopsy punch (Example 2). In another embodiment, the excisional wounds are induced by freezing or cryoinjury. The use of freezing or cryoinjury is well known in the art, and is used, for example by dermatologists to injure skin. In one embodiment, the freezing or cryoinjury results in a blister. In another embodiment, the blister is used as a “chamber” to introduce drugs and or cells into the reepithelialized area. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the excisional wounds of methods of the present invention are not surgically closed. In another embodiment, the excisional wounds are not contacted with a bandage or dressing before they heal or during a period of time after wound induction. In another embodiment, the excisional wounds are not contacted with an ointment before they heal or during a period of time after wound induction. In another embodiment, the excisional wounds are allowed to heal by secondary intention. Each possibility represents a separate embodiment of the present invention.
The subject of methods of the present invention, is, in another embodiment, a human. As provided herein (Example 7) human skin responds to EDIHN in the same manner as mouse skin. In another embodiment, the subject is a male. In another embodiment, the subject is a female. In another embodiment, the subject is any other type of subject known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the subject is an adult. In one embodiment, “adult” refers to an age greater than about 18 years. In another embodiment, “adult” refers to an age greater than about 20 years. In another embodiment, “adult” refers to an age greater than about 25 years. In another embodiment, “adult” refers to an age greater than about 30 years. In another embodiment, “adult” refers to an age greater than about 35 years. In another embodiment, “adult” refers to an age greater than about 40 years. In another embodiment, “adult” refers to an age greater than about 45 years.
In another embodiment, the subject is elderly. In one embodiment, “elderly” refers to an age greater than about 45 years. In another embodiment, “elderly” refers to an age greater than about 50 years. In another embodiment, “elderly” refers to an age greater than about 55 years. In another embodiment, “elderly” refers to an age greater than about 60 years. In another embodiment, “elderly” refers to an age greater than about 65 years. In another embodiment, “elderly” refers to an age greater than about 70 years.
In another embodiment, the first subject, or, where applicable, both the first subject and the second subject, is a laboratory animal. In another embodiment, the subject(s) is/are mice. In another embodiment, the subject(s) is/are rats. In another embodiment, the subject(s) is/are gerbils. In another embodiment, the subject(s) is/are hamsters. In another embodiment, the subject(s) is/are guinea pigs. In another embodiment, the subject(s) is/are rabbits. In another embodiment, the subject(s) is/are pigs. In another embodiment, the subject(s) is/are dogs. In another embodiment, the subject(s) is/are cats. In another embodiment, the subject(s) is/are primates. In another embodiment, the subject(s) is/are any other laboratory animal known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the subject(s) has a disease or disorder comprising balding. In another embodiment, the subject(s) does not have a disease or disorder comprising balding. In another embodiment, the disease or disorder is androgenetic alopecia (AGA). In another embodiment, the disease or disorder is male pattern baldness. In another embodiment, the disease or disorder is female pattern baldness. In another embodiment, the disease or disorder is a discoid lupus erythematosis. In another embodiment, the disease or disorder is a congenital hypotrichosis. In another embodiment, the disease or disorder is a lichen planopilaris. In another embodiment, the disease or disorder is a scarring alopecia. In another embodiment, the disease or disorder is any other disease or disorder comprising balding known in the art.
In another embodiment, the scalp, eyebrow, or scarred region(s) has a majority of HF in the telogen stage of the hair cycle. The findings of Examples 5-6 show that (a) EDIHN can restore hair growth to the scalp, eyebrow, or scarred region at the telogen stage; and (b) the efficiency of EDIHN at the telogen stage can be enhanced by depilation prior to abrasion or wound induction. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 60% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 70% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 80% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 90% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) does not have a majority of HF in the telogen stage of the hair cycle. Each possibility represents a separate embodiment of the present invention.
In another embodiment of methods and compositions of the present invention, the first step (e.g. epithelial disruption) is performed 3-12 days prior to the second step (e.g. addition of an active compound, factor, cell, etc). In another embodiment, the interval is 4-12 days. In another embodiment, the interval is 5-12 days. In another embodiment, the interval is 4-11 days. In another embodiment, the interval is 6-11 days. In another embodiment, the interval is 6-10 days. In another embodiment, the interval is 6-9 days. In another embodiment, the interval is 6-8 days. In another embodiment, the interval is 7-8 days. In another embodiment, the interval is 5-11 days. In another embodiment, the interval is 5-10 days. In another embodiment, the interval is 7-10 days. In another embodiment, the interval is about 1 week. Each possibility represents a separate embodiment of the present invention.
In another embodiment, a method of the present invention further comprises the step of suppressing an activity or expression of a Wnt protein in the scalp, eyebrow, or scarred region. As provided herein, suppressing Wnt activity induces pigmentation in HF generated by methods of the present invention. In another embodiment, the step of suppressing Wnt activity or expression is performed within about 10 days of epidermal disruption. In another embodiment, the step of suppressing Wnt activity or expression is performed prior to the second step (e.g prior to addition of a compound or factor that promotes HF cell differentiation. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a method for inducing pigmentation of a hair, comprising suppressing expression of a Wnt protein in a follicle of the hair. In another embodiment, the Wnt protein is Wnt1. In another embodiment, the Wnt protein is a Wnt7. In another embodiment, the Wnt protein is a Wnt7a. In another embodiment, the Wnt protein is a Wnt3. In another embodiment, the Wnt protein is a Wnt3a. In another embodiment, the Wnt protein is a Wnt10. In another embodiment, the Wnt protein is a Wnt10a. In another embodiment, the Wnt protein is any other Wnt protein known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a method for inducing growth of a pigmented scalp hair or eyebrow of a subject, comprising generating a hair follicle in the scalp, eyebrow, or scarred region according to a method of the present invention and suppressing expression of a Wnt protein in the hair follicle, thereby inducing a growth of a pigmented scalp hair or eyebrow of a subject.
In another embodiment, the step of suppressing expression of a Wnt protein comprises inducing an expression of a Dkk1 protein. In another embodiment, the step of suppressing expression of a Wnt protein comprises inducing an expression of any other Wnt inhibitor known in the art. In another embodiment, the step of suppressing expression of a Wnt protein is performed immediately or shortly after epidermal disruption. In another embodiment, the step of inducing expression of a Dkk1 protein is performed immediately or shortly after epidermal disruption. In another embodiment, the step of suppressing expression of a Wnt protein is performed at the time of epidermal disruption. In another embodiment, the step of inducing expression of a Dkk1 protein is performed at the time of epidermal disruption. In another embodiment, the step of suppressing expression of a Wnt protein is performed several days before generation of the follicle. In another embodiment, the step of inducing expression of a Dkk1 protein several days before generation of the follicle. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 8 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 8 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 9 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 9 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 10 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 10 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 12 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 12 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed during the period of re-epithelialization. In another embodiment, the step of inducing expression of a Dkk1 protein is performed during the period of re-epithelialization. In another embodiment, expression of a Dkk1 protein is halted after several days. In another embodiment, halting expression of Dkk1 protein after several days induces, or enables induction of Wnt protein expression. In another embodiment, the expression of a Wnt protein is induced about 9 days after the abrating or wounding. In another embodiment, the expression of a Wnt protein is induced following the period of re-epithelialization. In another embodiment, induction of Wnt protein expression is necessary for formation of new HF. Each possibility represents a separate embodiment of the present invention.
In another embodiment, “several” refers to about 1 day. In another embodiment, “several” refers to about 2 days. In another embodiment, “several” refers to about 3 days. In another embodiment, “several” refers to about 5 days. In another embodiment, “several” refers to about 7 days. In another embodiment, “several” refers to about 10 days. In another embodiment, “several” refers to about 12 days. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the step of contacting in methods of the present invention comprises directly contacting the scalp, eyebrow, or scarred region with the compound, RNA, protein, etc. In another embodiment, the step of contacting comprises indirectly contacting the scalp, eyebrow, or scarred region via contacting another site or tissue of the subject, after which the compound, RNA, or protein is transported to the scalp, eyebrow, or scarred region by a biological process; e.g, diffusion, active transport, or circulation in a fluid such as the blood, lymph, interstitial fluid, etc. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the epidermal disruption in methods of the present invention further removes dermal tissue from the scalp, eyebrow, or scarred region. In another embodiment, the epidermal disruption does not remove dermal tissue from the scalp, eyebrow, or scarred region. Each possibility represents a separate embodiment of the present invention.
“Disrupting” an epidermis or epidermal layer refers, in another embodiment, to removing part of the epidermis or epidermal layer. In another embodiment, the term refers to disturbing the intactness of the epidermis or epidermal layer. In another embodiment, the term refers to perforating the epidermis or epidermal layer. In another embodiment, only part of the epidermal layer need be removed. In another embodiment, the entire epidermal layer is removed. In another embodiment, the term refers to abrading the epidermis or epidermal layer (Examples). In another embodiment, the term refers to wounding the epidermis or epidermal layer (Examples). Each possibility represents a separate embodiment of the present invention.
In another embodiment, the epidermal disruption is performed with a tool that comprises sandpaper. In another embodiment, the epidermal disruption is performed with a laser. In another embodiment, the laser is a Fraxel laser. In another embodiment, the laser is a CO2 laser. In another embodiment, the laser is an excimer laser. In another embodiment, the laser is any other type of laser capable of inducing trans-epithelial injury. In another embodiment, the epidermal disruption is performed with a felt wheel. In another embodiment, the epidermal disruption is performed with a surgical tool. In another embodiment, the epidermal disruption is performed with any other tool known in the art that is capable of epidermal disruption. In another embodiment, the epidermal disruption comprises use of a micro-dermabrasion device. In another embodiment, the epidermal disruption comprises a burn treatment.
In another embodiment, the epidermal disruption comprises a disruption of a follicle of said epidermis and a disruption of an interfollicular region of said epidermis. In another embodiment, the epidermal disruption comprises a disruption of a follicle of said epidermis and does not comprise a disruption of an interfollicular region of said epidermis. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the epidermal disruption comprises a light-based method. In another embodiment, the epidermal disruption comprises irradiation with visible light. In another embodiment, the epidermal disruption comprises irradiation with infrared light. In another embodiment, the epidermal disruption comprises irradiation with ultraviolet radiation. In another embodiment, the epidermal disruption comprises orthovoltage irradiation. In another embodiment, the epidermal disruption comprises X-ray irradiation. In another embodiment, the epidermal disruption comprises any other type of irradiation known in the art.
In another embodiment, the epidermal disruption is performed by mechanical means. In another embodiment, “mechanical means” refers to abrading. In another embodiment, the term refers to wounding. In another embodiment, the term refers to ultrasound. In another embodiment, the term refers to radio-frequency. In another embodiment, the term refers to ab electrical process or the use of an electrical current. In another embodiment, the term refers to electroporation. In another embodiment, the term refers to exision. In another embodiment, the term refers to tape-stripping. In another embodiment, the term refers to microdermabrasion. In another embodiment, the term refers to the use of peels. In another embodiment, the term refers to any other type of mechanical means known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the epidermal disruption comprises chemical treatment. In another embodiment, the chemical is phenol. In another embodiment, the chemical is trichloracetic acid. In another embodiment, the chemical is ascorbic acid. In another embodiment, the chemical is any other chemical capable of epidermal disruption that is known in the art.
Each method or type of method of epidermal disruption represents a separate embodiment of the present invention.
In another embodiment, epidermal trauma is utilized in a method of the present invention.
Each type of epidermal abrasion and epidermal trauma represents a separate embodiment of the present invention.
In another embodiment, the epidermal disruption of methods of the present invention creates an abrasion at least about 1-1.5 centimeters (cm) in width. In another embodiment, the abrasion is at least about 1 cm in width. In another embodiment, the abrasion is at least about 1.5 cm in width. In another embodiment, the abrasion is at least about 2 cm in width. Each type of abrasion represents a separate embodiment of the present invention.
In another embodiment, the scalp, eyebrow, or scarred region is not contacted with a bandage or dressing following the epidermal disruption. In another embodiment, the scalp, eyebrow, or scarred region is not contacted with an ointment following the epidermal disruption. In another embodiment, the scalp, eyebrow, or scarred region is allowed to heal for a period of time without being contacted by any substance, device, ointment, etc., that is ordinarily administered to an abrasion or wound to facilitate healing. In another embodiment, the scalp, eyebrow, or scarred region is allowed to heal for a period of time without being contacted by any substance, device, ointment, etc., that is ordinarily administered to an abrasion or wound to prevent infection. In another embodiment, the period of time is the time it takes the epidermal disruption to heal. In another embodiment, the period of time is any time or range of times between 2 days and 3 weeks. Each possibility represents a separate embodiment of the present invention.
In one embodiment, “following” refers to a period of time of about 2 days. In another embodiment, “following” refers to a period of time of about 3 days. In another embodiment, “following” refers to a period of time of about 4 days. In another embodiment, “following” refers to a period of time of about 5 days. In another embodiment, “following” refers to a period of time of about 7 days. In another embodiment, “following” refers to a period of time of about 10 days. In another embodiment, “following” refers to a period of time of about 2 weeks. In another embodiment, “following” refers to a period of time of about 3 weeks. Each possibility represents a separate embodiment of the present invention.
In another embodiment, a method of the present invention further comprises the step of depilating the scalp, eyebrow, or scarred region. As provided herein, the findings of Example 6 show that the efficiency of EDIHN can be enhanced by depilation prior to abrasion or wound induction.
In another embodiment, the depilation is epilation. In another embodiment, the depilation comprises the step of waxing. In another embodiment, the depilation comprises the step of plucking. In another embodiment, the depilation comprises the use of an abrasive material. In another embodiment, the depilation comprises the use of a laser. In another embodiment, the depilation comprises the use of electrolysis. In another embodiment, the depilation comprises the use of a mechanical device. In another embodiment, the depilation comprises the use of thioglycolic acid. In another embodiment, the depilation comprises the use of any other method of depilation or epilation known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, a method of the present invention further comprises the step of administering a topical retinoid to the scalp, eyebrow, or scarred region. In one embodiment, the topical retinoid induces resting (telogen) HF in the scalp, eyebrow, or scarred region to enter anagen. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the additional step (depilation or administration of a retinoid) is performed prior to the step of disrupting the epidermis. In another embodiment, the additional step is performed following the step of disrupting the epidermis, but prior to the addition of the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell. In another embodiment, the additional step is performed concurrently with the addition of the differentiation-promoting compound or factor. In another embodiment, the additional step is performed following the addition of the differentiation-promoting compound or factor. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the additional step is performed between about two days and about three weeks before the step of abrading. In another embodiment, the additional step is performed about two days before the step of abrading. In another embodiment, the additional step is performed about three days before the step of abrading. In another embodiment, the additional step is performed about four days before the step of abrading. In another embodiment, the additional step is performed about one week before the step of abrading. In another embodiment, the additional step is performed about ten days before the step of abrading. In another embodiment, the additional step is performed about two weeks before the step of abrading. In another embodiment, the additional step is performed about three weeks before the step of abrading. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the methods of the present invention further comprise the step of contacting the scalp, eyebrow, or scarred region with an inductive cell capable of inducing an epidermal cell to differentiate into an HF cell. In another embodiment, the HF cell is an HF stem cell. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the inductive cell is a dermal papilla cell. In another embodiment, the inductive cell is a follicular papilla cell. In another embodiment, the inductive cell is a dermal sheath cell. In another embodiment, the inductive cell is a cell that has been genetically modified; for example, with a gene encoding a factor that activates one of the proteins or pathways shown in the present invention to be up-regulated in HF stem cells. In one embodiment, the factor is hedgehog. In another embodiment, the factor is a DP cell protein. In another embodiment, the factor is wingless/int (wnt). In another embodiment, the factor is a Noggin protein. In another embodiment, the factor is a bone morphogenic protein (BMP). In another embodiment, the factor is a fibroblast growth factor (FGF). In another embodiment, the factor is a transforming growth factor beta (TGF-beta) protein. In another embodiment, the factor is sonic hedgehog protein. In another embodiment, the factor is a neurotropin. In another embodiment, the factor is any other factor known in the art that can contribute to induction of an epidermal cell to differentiate into an HF cell. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the inductive cell has been genetically modified with a gene encoding a factor that represses one of the proteins or pathways shown in the present invention to be down-regulated in HF stem cells. In another embodiment, the inductive cell has been genetically modified with a gene encoding a factor that activates one of the proteins or pathways shown in the present invention to be up-regulated in HF stem cells upon their activation.
In another embodiment, the inductive cell is an autologous cell. In another embodiment, the inductive cell is an allogenic cell.
In another embodiment, the inductive cell is derived from a mesenchymal stem cell. In another embodiment, the inductive cell is derived from a mesodermal progenitor cell. In another embodiment, the inductive cell is derived from a hematopoietic stem cell. In another embodiment, the inductive cell is derived from an embryonic stem cell. In another embodiment, the inductive cell is derived from an embryonic carcinoma cell. In another embodiment, the inductive cell is one of the cell types disclosed in United States Patent Application No. 2003/0201815. In another embodiment, the inductive cell is any other type of cell known in the art with inductive properties for an epidermal cell. Each type of inductive cell represents a separate embodiment of the present invention.
In another embodiment, the epidermal cell (e.g. the epidermal cell that is induced to differentiate into an IF cell) is an epidermal stem cell. In another embodiment, the epidermal cell is a bulge cell. In another embodiment, the epidermal cell is any other type of cell known in the art that can be induced to differentiate into an HF stem cell. Each possibility represents a separate embodiment of the present invention.
In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an anti-androgen compound. In one embodiment, the anti-androgen compound is finasteride. In another embodiment, the anti-androgen compound is Fluridil®. In another embodiment, the anti-androgen compound is dutasteride. In another embodiment, the anti-androgen compound is spironolactone. In another embodiment, the anti-androgen compound is cyproterone acetate. In another embodiment, the anti-androgen compound is bicalutamide. In another embodiment, the anti-androgen compound is flutamide. In another embodiment, the anti-androgen compound is nilutamide. In another embodiment, the anti-androgen compound is an inhibitor of an androgen receptor. In another embodiment, the anti-androgen compound is any other anti-androgen compound known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an estrogen compound. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an estrogen receptor agonist. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an estrogen analogue. In one embodiment, the estrogen analogue is estradiol. In another embodiment, the estrogen analogue is 17 beta-estradiol. In another embodiment, the estrogen analogue is 17 alpha-estradiol. In another embodiment, the estrogen analogue is ZYC3. In another embodiment, the estrogen compound, estrogen receptor agonist, or estrogen analogue is any other estrogen compound, estrogen receptor agonist, or estrogen analogue known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an inhibitor of an EGF protein. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an inhibitor of an EGFR. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a compound that reduces an expression of an EGF protein or an EGFR. Each possibility represents a separate embodiment of the present invention.
In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a Hedgehog protein. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a nucleotide encoding a Hedgehog protein. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an activator of a Hedgehog protein. Each possibility represents a separate embodiment of the present invention.
In one embodiment, a scalp is treated by a method of the present invention. In another embodiment, an eyebrow is treated. In another embodiment, any other hair-bearing area or region of the skin is treated. Each possibility represents a separate embodiment of the present invention.
In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a lithium compound. In one embodiment, the lithium compound contains a lithium ion. In another embodiment, the lithium compound contains a lithium atom.
In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with (2′Z,3′E)-6-bromoindirubin-3′-oxime (BIO). In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with any other compound known in the art that is capable of inducing an epidermal cell to differentiate into an HF stem cell. Each compound represents a separate embodiment of the present invention.
In one embodiment, the compound administered as part of methods of the present invention is administered systemically. In another embodiment, the compound is administered topically. In another embodiment, the compound is administered to the site of the abrasion. In another embodiment, the compound is administered to the site of the wound induction. In another embodiment, the compound is administered to the site of the depilation. In another embodiment, the compound is administered during wound healing. In another embodiment, the compound is administered prior to HF neo-genesis. In another embodiment, the compound is administered during HF neo-genesis. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a method of inducing formation of an HF stem cell, comprising performing a method of the present invention. In another embodiment, the present invention provides a method of inducing formation of a DP cell, comprising performing a method of the present invention. Each possibility represents a separate embodiment of the present invention.
In another embodiment, homologues and variants of transcripts and proteins of the present invention are administered in methods of the present invention. In another embodiment, homologues and variants of transcripts and proteins of the present invention are targeted in methods of the present invention. Each possibility represents a separate embodiment of the present invention.
The terms “homology,” “homologous,” etc, when in reference to any protein or peptide, refer in one embodiment, to a percentage of amino acid residues in the candidate sequence that are identical with the residues of a corresponding native polypeptide, after aligning the sequences and introducing gaps, if necessary, to achieve the maximum percent homology, and not considering any conservative substitutions as part of the sequence identity. Methods and computer programs for the alignment are well known in the art.
In another embodiment, the term “homology,” when in reference to any nucleic acid sequence similarly indicates a percentage of nucleotides in a candidate sequence that are identical with the nucleotides of a corresponding native nucleic acid sequence.
In another embodiment, “homology” refers to identity of greater than 70%. In another embodiment, “homology” refers to identity of greater than 75%. In another embodiment, “homology” refers to identity of greater than 80%. In another embodiment, “homology” refers to identity of greater than 82%. In another embodiment, “homology” refers to identity of greater than 85%. In another embodiment, “homology” refers to identity of greater than 87%. In another embodiment, “homology” refers to identity of greater than 90%. In another embodiment, “homology” refers to identity of greater than 92%. In another embodiment, “homology” refers to identity of greater than 95%. In another embodiment, “homology” refers to identity of greater than 97%. In another embodiment, “homology” refers to identity of greater than 98%. In another embodiment, “homology” refers to identity of greater than 99%. In another embodiment, “homology” refers to identity of 100%.
Protein and/or peptide homology for any amino acid sequence listed herein is determined, in one embodiment, by methods well described in the art, including immunoblot analysis, or via computer algorithm analysis of amino acid sequences, utilizing any of a number of software packages available, via established methods. Some of these packages may include the FASTA, BLAST, MPsrch or Scanps packages, and may employ the use of the Smith and Waterman algorithms, and/or global/local or BLOCKS alignments for analysis, for example. Each method of determining homology represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a kit, comprising a tools and/or a compound suitable for performing a method of the present invention.
In another embodiment, the present invention provides a device, comprising a tool suitable for epidermal disruption and a means of delivering a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell.
In other embodiments, the present invention provides a method of treating any disease, disorder, or symptom associated with balding. In other embodiments, the present invention provides a method of treating any disease, disorder, or symptom associated with balding. In other embodiments, the present invention provides a method of treating any disease, disorder, or symptom associated with balding. Each disease, disorder, or symptom represents a separate embodiment of the present invention.
Pharmaceutical Compositions In another embodiment, methods of the present invention comprise administering a pharmaceutical composition comprising the HF stem cell-inducing or -activating compound and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or any combination thereof: and a pharmaceutically acceptable carrier. Each possibility represents a separate embodiment of the present invention.
The pharmaceutical compositions containing the HF stem cell-inducing or -activating compound can, in another embodiment, be administered to a subject by any method known to a person skilled in the art, such as topically, parenterally, paracancerally, transmucosally, transdermally, intramuscularly, intravenously, intradermally, subcutaneously, intraperitonealy, intraventricularly, intracranially, intravaginally or intratumorally. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the pharmaceutical compositions are administered orally, and are thus formulated in a form suitable for oral administration, i.e. as a solid or a liquid preparation. Suitable solid oral formulations include tablets, capsules, pills, granules, pellets and the like. Suitable liquid oral formulations include solutions, suspensions, dispersions, emulsions, oils and the like. In one embodiment of the present invention, the HF stem cell-inducing or -activating compounds are formulated in a capsule. In another embodiment, the compositions of the present invention comprise, in addition to the HF stem cell-inducing or -activating compound active compound and the inert carrier or diluent, a hard gelating capsule.
In another embodiment, the pharmaceutical compositions are administered topically to body surfaces and are thus formulated in a form suitable for topical administration. Suitable topical formulations include gels, ointments, creams, lotions, drops and the like. For topical administration, the HF stem cell-inducing or -activating compound or its physiologically tolerated derivatives such as salts, esters, N-oxides, and the like are prepared and applied as solutions, suspensions, or emulsions in a physiologically acceptable diluent with or without a pharmaceutical carrier.
In another embodiment, the pharmaceutical compositions are administered by subcutaneous implantation of a pellet. In another embodiment, the pellet provides for controlled release of HF stem cell-inducing or -activating compound agent over a period of time.
For liquid formulations, pharmaceutically acceptable carriers are, in another embodiment, aqueous or non-aqueous solutions, suspensions, emulsions or oils. Examples of non-aqueous solvents are propylene glycol, polyethylene glycol, and injectable organic esters such as ethyl oleate. Aqueous carriers include, in another embodiment, water, alcoholic/aqueous solutions, emulsions or suspensions, including saline and buffered media. Examples of oils are those of petroleum, animal, vegetable, or synthetic origin, for example, peanut oil, soybean oil, mineral oil, olive oil, sunflower oil, and fish-liver oil.
In one embodiment, the pharmaceutical compositions are controlled-release compositions, i.e. compositions in which the HF stem cell-inducing or -activating compound is released over a period of time after administration. Controlled- or sustained-release compositions include, in another embodiment, formulation in lipophilic depots (e.g. fatty acids, waxes, oils). In another embodiment, the composition is an immediate-release composition, i.e. a composition in which all the HF stem cell-inducing or -activating compound is released immediately after administration.
EXPERIMENTAL DETAILS SECTION Example 1 Depilation and Epidermal Abrasion Causes De Novo Hair Follicle Formation Materials and Experimental Methods Depilation and Epidermal Abrasion Mice were anesthetized with an injection of sodium pentobarbital before the hair on the back was clipped and depilated with Nair (Carter-Wallace, New York, N.Y.), then epidermis was removed using a rotating felt wheel as described by Argyris T, J Invest Dermatol, 75: 360-362, 1980). After scrubbing with 70% ethanol and drying under an incandescent lamp, the basal and supra-basal layers in an area of (1.5 cm)2 cm of the inter-follicular epidermis were removed by careful abrasion with a felt wheel mounted on a Dremel Moto-tool (Racine, Wis.). After abrasion, the skin was shiny and smooth, and there was no blood. One day later, the abraded area was covered by a fibrin crust, which fell off after 3-7 days, exposing the newly regenerated epidermis. A group of control mice was sacrificed immediately after abrasion to confirm microscopically the complete removal of the interfollicular epidermis.
Immunohistochemistry Skin samples were fixed in PBS-buffered 10% formalin. Six-micron thick paraffin sections were cut and stained, where applicable, with antibodies.
BrdU Labeling The protocol described by Bickenbach and colleagues (Bickenbach et al, Cell Tiss Kinet 19: 325-333, 1986; Bickenbach et al, Exp Cell Res 244, 184-195, 1998) was used. Mice were injected with 50 milligrams per kilogram (mg/kg) bodyweight 5-bromo-2′-deoxyuridine (BrdU) every 12 hours for a total of four injections.
Results An area of the backs of 50-day old mice was subjected to depilation and removal of the epidermis using a rotating felt wheel. Fifteen days later, HF placodes, hair germs and other signs of follicle neogenesis were present (FIG. 1; arrow indicates a hair germ). Morphology of the follicles was similar to embryonic follicle development. To further characterize proliferation in the new follicles, the skin was labeled with BrdU 60 minutes before sacrifice. As depicted in FIG. 2, the proliferation pattern was similar to developing follicles in the embryo.
These findings demonstrate that (a) disruption of the epidermis causes generation of new HF, and that this generation of new HF can occur (b) in adult subjects and (c) during telogen (50-day-old mice are in the second telogen stage of the hair cycle).
Example 2 Induction of a Large Excisional Wound, but not a Small Punch Wound, Causes De Novo Hair Follicle Formation Materials and Experimental Methods Punch Wound and Excisional Wound Induction The backs of 21-day-old mice were depilated as described for Example 1 and sterilized with alcohol, followed by 1% iodine solution. Punch wounds, 4 mm in diameter, were induced using a dermal biopsy punch, down to, but not through, the muscle fascia. Excisional wounds were full thickness and 1 cm in diameter; skin and panniculus carnosus was excised using fine surgical scissors.
Results To test whether wounding could induce HF formation, punch wounds or excisional wounds were induced in mice. Both types of wounds exhibited contraction and re-epithelialization following wound induction; however, unlike the mice receiving punch wounds, the mice receiving excisional wounds also exhibited scar formation within 10 days of wound induction (FIG. 3, left panel). No follicles were evident at this time point (FIG. 3, right panel). 12 days after wound induction, hair germs, with similar morphology to fetal hair germs, were observed in the wound site, following BrdU pulse labeling (FIG. 4). Several markers were used to verify that the observed structures were HF. The structures exhibited staining with anti-keratin 17 (K 17), an HF marker (FIG. 5), and staining with anti-alkaline phosphatase at the 12 day time point verified that the structures had dermal papilli containing fibroblasts, as expected for HF (FIG. 6; HF at earlier and later stages are depicted in the left and right panels, respectively).
The HF generated by wound induction were further characterized by morphological comparison to embryonic HF, following BrdU staining; a clear correspondence in morphology was observed at various stages (FIG. 7). In addition, several markers of embryonic HF development, namely Lef1, wingless/int (Wnt) 10b, and sonic hedgehog (Shh), were also induced in the epidermal disruption-induced HF neogenesis (EDIHN) (FIG. 8). Additional BrdU staining (FIG. 9) and staining for HF markers S100A3 and S100A6 (FIG. 10; left panel: tissue section parallel to HF axis; right panel: cross-sectional view of follicle) provided further verification that the development of the EDIHN follicles closely paralleled embryonic HF development.
These findings provide further evidence that disruption of the epidermis causes generation of new HF, and that this generation of new HF can occur (b) in adult subjects and (c) during telogen (21-day-old mice are in the first telogen stage of the hair cycle).
Example 3 EDIHN-Induced Hair Follicles Generate Hairs At 25 and 45 days after wound induction, wound sites contained new hairs (FIG. 11, left and right panels, respectively). New hairs appeared to lack pigmentation, except when the wnt pathway was inhibited, using Dkk-1 (Dickkopf-1) during the first nine days after wounding (see Example 10).
These findings indicate that EDIHN-induced HF function normally; i.e. are capable of generating hairs.
Example 4 EDIHN Hair Follicles Retain the Ability to Enter into Cyclical Hair Growth Materials and Experimental Methods BrdU Labeling 50 mg/kg bodyweight BrdU (Sigma) was injected twice per day for 3 days beginning 20 days after wounding. BrdU was detected 40 days after wounding (17 day chase).
Whole Mounting and Immunofluorescence HF whole mounts were obtained by incubating fresh skin with EDTA (20 mM in PBS) at 37° C. overnight, then separating the epidermis and dermis. Epidermis was then fixed in 10% formalin for 10 min, room temperature (RT). Dermis was fixed in acetone overnight, RT. After rinsing with PBS, whole mounts were stained with antibodies for immunohistochemistry (schematically depicted in FIG. 12) and were imaged using a Leica confocal microscope.
Results To determine whether EDIHN-induced HF contain normal levels of HF stem cells, mouse skin was examined for the presence of label-retaining cells at 21 days after wound induction. Retention of BrdU during a long chase period is, under these conditions, one of the hallmarks of HF stem cells. Normal numbers and placement of label-retaining cells (in the bulge of the HF) were observed (FIG. 13). To verify that the label-retaining cells were HF stem cells, K15-eGFP mice were utilized. In these mice, eGFP (enhanced green fluorescent protein) is expressed from the K15 promoter; thus, expression of eGFP identifies HF stem cells. As depicted in FIG. 14A, eGFP-expressing cells were observed in in tissue sections (right side) of newly formed hair follicles 35 days following wound induction. eGFP-expressing cells were also seen in the epidermis whole mounts (bottom, far left panel) indicating the conversion of epidermal cells into cells with hair follicle stem cell characteristics. ([bottom, second from left] panel is same as [bottom, far left] panel but viewed under white light) This finding shows that the observed label-retaining cells exhibited HF stem cell properties.
To determine whether EDIHN-induced HF cycle normally, mounts were prepared from additional mice at 35, 38 and 45 days after wounding. As depicted in FIG. 14B, the EDIHN-induced HF entered the resting phase, telogen, and then re-entered a new anagen stage.
In summary, the findings of this Example show that EDIHN-induced HF contain HF stem cells, as do embryonically generated HF. The presence of the HF stem cells shows that EDIHN-induced HF retain the ability to enter into cyclical hair growth in the same manner as embryonically generated HF. The findings also show that wounding induces epidermal cells to assume a hair follicle stem cell state (expressing K15-eGFP). This model is shown schematically in FIG. 15. The findings of Examples 2, 3, and 4 show that EDIHN-induced HF are fully functional and thus able to restore hair growth to a subject in need.
Example 5 EDIHN-Induces New Hair Follicles in Mice at the Telogen Stage of the Hair Cycle To determine whether EDIHN was induced new hair follicles in mice wounded at the telogen stage of the hair cycle, 21-day-old mice were subjected to EDIHN using a 1-cm excisional wound, as described in Example 2. Skin was then examined by whole-mount assay for indications of new HF. As depicted in FIG. 16, after 11 days, new HF were not evident by macroscopic examination (top panel), AP staining of the dermis (bottom left panel), or K17 staining of the epidermis (bottom right panel). After 14 days, as depicted in FIG. 17, dermal papilla cells were detected in the dermis (left panel) and HF stem cells in the epidermis (right panel), demonstrating that new follicles were being formed. After 17 days, the new follicles were more developed, as shown by examination of the dermis and epidermis (FIG. 18, left and right panels, respectively). This method induced formation of an average of 49 new follicles in the wound, a number that was consistent over three separate experiments, as depicted in Table 1.
TABLE 1
Results of three separate experiments
performed on 21-day-old mice.
Sample Expt 1 Expt 2 Expt 3 Avg of expts Std dev of expts
1 24 70 55
2 29 52 25
3 27 85 53
4 102 25 80
5 53 27 23
Average 47 51.8 47.2 48.67 2.71
Std dev 32.8 26.3 23.7
The findings of this Example demonstrate that EDIHN is capable of inducing formation of new HF in mice at the telogen stage of the hair cycle, despite that fact that these mice do not contain HF at the anagen stage during wounding.
Example 6 In Adult Mice, Induction of Anagen Increases the Efficiency of EDIHN The experiment described in Example 5 was repeated with mice of different ages, and therefore at different stages of the hair cycle. To ensure that wound scarring occurred, larger wounds were in induced in the older mice. As depicted in Table 2, adult mice at telogen, such as 8-week-old mice, exhibited lower efficiencies of HF formation by EDIHN.
TABLE 2
Efficiency of HF formation by EDIHN in adult
mice at various stages of the hair cycle.
Wound Days after Mice exhibiting
Age size wound EDIHN Hair cycle
3 wk 1 cm 20 25/25 (100%) Telogen
4 wk 1 cm 20 5/5 (100%) Early anagen
5 wk 1 cm 20 1/2 (50%) Anagen
8 wk 1.5 cm 30 16/35 (46%) Telogen
14 wk 1.5 cm 30 1/2 (50%) N/A*
20 wk 1.5 cm 30 2/2 (100%) N/A*
*The second telogen lasts approximately 40 days in mice. Thus, 14-week-old and 20- week-old mice contained a mixture of telogen and anagen HF.
To determine whether experimental induction of anagen increased the efficiency of EDIHN, 8-week-old mice were depilated several days prior to wound induction. As depicted in FIG. 19, the wounds closed similarly whether or not they were preceded by depilation. As depicted in FIG. 20A-B, the depilated mice exhibited enhanced EDIHN relative to the non-depilated mice depicted in the previous Example by a factor of 11-fold.
The findings of this Example demonstrate that anagen induction enhances EDIHN. In addition, these findings show that EDIHN is capable of not only forming new HF, but also of activating anagen in pre-existing HF in the telogen stage.
Example 7 EDIHN-Induces New Hair Follicles in Human Skin Materials and Experimental Methods Grafting Discarded human adult scalp from the preauricular area obtained from plastic surgery was grafted onto immunodeficient (scid) mice. The graft was bandaged and allowed to heal, then was used in the wound healing study 3 months after grafting.
Results To determine whether human skin responded to EDIHN as did mouse skin, human skin was grafted onto SCID (immuno-deficient) mice and subjected to depilation by plucking and wound induction three days later. Seven days following wound induction, formation of new HF was observed in the human skin (FIG. 21A; arrows indicate new HF) by hematoxylin and eosin staining of paraffin embedded tissue sections.
In additional experiments, adult human skin was grafted onto mice, abraded, and examined at 7 days post-abrasion. New HF were generated in the human skin, which mimicked normal hair follicle formation during fetal development, as evidenced by staining for S100A6 or S100A4 (FIG. 21B).
The results of this Example show that EDIHN can be used to generate hair growth in human skin as for mouse skin.
Example 8 Molecular Pathways Activated During HF Stem Cell Activation Materials and Experimental Methods Isolation and Activation of HF Stem Cells K15-eGFP mice were depliated in order to induce formation of new HF. Activated hair follicle stem cells were isolated from K15-eGFP mice using fluorescence-activated cell sorting (FACS) two days after depilation and 5 μg (micrograms) total RNA from the cell population was isolated, reverse-transcribed and hybridized to an Affymetrix (Santa Clara, Calif.) array MG_U74v2 chip. Scanned chip images were analyzed using Affymetrix Microarray Suite 5.0 and GeneSpring software (Silicon Genetics) to detect fold-change differences between activated HF stem cells (HFSCs) and non-activated (telogen) HFSCs. Values were normalized before computing fold-changes and differences between non-activated “bs-line” and activated (“expt”) samples.
Results To identify molecular pathways up-regulated during HF stem cell activation, activated HF stem cells were isolated, and the gene expression patterns of the cells were analyzed to detect up-regulated transcripts. The transcripts depicted in Table 3 were up-regulated at least 2-fold in the activated HF stem cells relative to the cells prior to activation. In some cases, the sequence in Table 3 is a genomic sequence that contains the sequence of the transcript. Data pertaining to the up-regulation of the transcripts and further information about them is provided in FIG. 22.
TABLE 3
RNA transcripts up-regulated during HF stein cell activation.
SEQ
ID
No: Access. # Sequence
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2 AF053235 Sequence below.
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cuugucccauuugguuucuuuggaugauguuugccuucaccaaauaaaauuugcucucuu
10 Y07836 caaccaccuccuaccugccugcccaaagcuccagggcuggagcacggagaccugucaggg
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ccagcucgucacucaucuccaucguguggucucggagcugcugcaggguggugcuuccagg
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aaggggacuugcgcagugaacagccguacuucaaaagcgaccauggacgcagguucgccgu
gggagaacgugucagcacaauuaagcaagaauccgaagagccccccaccacaaagagccgaa
ugcagcucucagaagaggaaggccacuucgcgggcagugaucugauggguuccccauuucu
ugggccacacccacaucagccuccuuuuugccuucccuucuaucucaucccaccaucggcca
cugccuaccugccuaugcuggagaaaugcugguaccccaccucugugccaguguauaccc
aggccucaacaccucagcugcagcccucuccagcuucaugaacccagacaagauaccgacucc
cuugcuucugccccagagacucccuucuccuuuggcacauucgucccuugacucuucggcc
uugcuccaggcuuugaagcagaucccuccuuuaaacuuagaaaccaaagacuaaacucugga
gggaucuccugcugccuugcuuucuuuccucccuaauuccaaaaaccacgaagguuucccu
gagugcagagagaucagcccacccugcagacccacagagaagauucagagugugugugaga
gugagugagugugcgugcgugcgugcuuguauguauguuuguauauguaggacaauaagu
uccuucugacacaagggagacacgagaaggauagccugacaucagaugacagacuggaggac
ucuaccacaucucucccccuuucccuacccaaauaauaacc
11 M21285 Sequence below.
uugcaggcgagggcuuccacaacuaccaccacaccuuccccuucgacuacucugccagugaguaccgcuggcacaucaacuu
caccacguucuucaucgacugcauggcugcccugggccuggcuuacgaccggaagaaaguuucuaaggcuacugucuuagc
caggauuaagagaacuggagacgggagucacaagaguagcugagcuuugggcuucugaguuccuguuuucaaacguuucu
ggcagagauuuaauauucuguugauuaacuaacaacuggauauugcuaucgggguguuaaugaugcauuuaaccuauucc
gguacaguauucuuauaaaaugagaaagcuuugaucacguuuugagguaauaauuauuuauuuagcuaggauuaaccau
gccacaagacauuauauauuucuaagcacacaugauaaaugcauauacaauuuugcacaacagcuuuaaauaauaacaauaa
auuugaacauucuauacagagaggaucaaagccaaggaacaugcuguuuugaugcuagggugagcauggugcucaguccc
uguuuguuugcaugguguccagcuuuguuucuuucucugucaucaccaccuucaggcaaauaguugaccaaccacuggccu
gugucuguccacccuccaaagcccaggccaccuuucuguuuucugaaauacugauccuuccuccugaauacaucccuccuu
guuccuagcuucaagacugcugccucaaauagggauagagcaaguccccgcugcagguugugcuagaugggauggagaaa
uuaucuucauuugauacagagcaaguagauuugucucgagagaaaaguuagcaugcgugguaugauuuguaaguaaagaug
gaagagagagagagagagagagagagagagagagagagagagagagagguagccauaucuaacagccuacuuaccaaagac
cccaggccucucugcuuggcaugccuccuuucuguccauccucugaaccccagagauuagugagauuugaauaauuaaauc
auuuucagagugaaggggguuaaugcagggucugugcuaggggaggguuuuagcuuuugguaucugaagauuuuuucau
ggaaaaagucuucguguucaaugugccuagaacugauaauuaaacagcugacauuugucggggacagauauggugugaaac
uaugaaaauauaagcaaaaucuucacuuggaacaugaaacuauuucacuuagaaaauaaucgaaggacccgagguguugcc
uggguugccaguuuucuuucguggcugggcaggaacuagugaggugaggggcagugucuguaaguagcugcuaagaggu
gcauuuccagaugaagcccuuggggaacaucugccagggauccgcaugguguuggcuccauccauugcuuuaguuuccuc
cuuggauuguguagnaacuuggcuucccaugguuuugaaccuuccaugccuucuuugcuuuguggccucccugccugccu
agugcugccuaggaagcucuuacccaccugauuuucugacauuucuuucuggccuggugggucuuucuccggacaug
cagcuaguugccugaguguaucaagagcacccaggacgggucaacaaaccgcggcgagagccaggaaccaaggggaca
uggaagagcuguguagcuucaggaagcagagccaggugccaccuuucuguggcuuccagauccucccuaccuccaacucau
gugccucugucacagugauuucaggaaagcuugguagacccucuagcaacaucucgguucagaaagucucucugguuugu
gaguuaacagcucagcuaagugcuguuuugucucagugaguuaaccacugaaugcgaggguugguuguugaucugucucg
gugugugucggaguagacagcauaugcacuucucccugugcgcuuugcaagguaauguggcuuuggcugauccaugcagg
cagguagugguacagugcugcugaaaggaagaaguuccccauuuuaucuguuaagcccgcgcccggaacaggaacaccg
uggaccucacuucaggaagagggucugcuuccugaagccagugugugaugaaaagugacugagaccugauaucuaaggug
agaccugauaccuaacacucugucacacaguccagggccaacagugcuauaggaaagucuagaagaaaacaucacaucagua
uuuuagaaccaucaaccaucucuugucccuauagcccaauccagaggccugguuuuuagaacuggcuguguaaggugccaa
acacucaguucacuuguagaaucagagccuuuuuuccccccuauguuaauugaacacgcgcucugagcuguuuuguugaa
guagaaaaucucauagaaaaaucacuguagaucuacugaccuauagcccucuggaaaugccuuugagaugguuuuacuuuu
cuaggucauagaugccugauuauaaagaugaacaauaaaaucagcuuucuuucuuucucuucugaucuuauuccccagauc
ugauucaggccauguuccaaagcaaggcuacauugagguccuggugucuuuaagggaaggacaucuuucagauccucucaa
agaaggauuuauaacaguuuccagaugaauguacuaauagcuuugggugccuuaucucuuuccuaaucugugugccugu
gagcucagucucacuccuucccuuagcccggagaccccuuagaucgagugggaauagucaagaggcuggcuggagagucau
caguacauugguugcagaaaucuuuuacaggcuacauuuuggaauuuuuuuuuuuuaguaagugaucaaauuuggug
ggaaguaauucgaguguauucgauuguauugucguccucguuaucauugucaaacauguuauagacggcaguuggcacug
gggcugcuaaucucuggguguagucucugaaacuguagcuccagugagguggugugaaagguuagcaaagccaccaucug
cuggugcuccagccaaggugccucuagccacugaauugcuauguuauccuuucucuuguaacaaacccaccccagagaua
aagccuuuaaucaacccaagaaacuccugggcuaaguaucugacagucucacaucucaacagugugaauuaaguguccaua
gcaucagcucaggaggacacucugggagagugcugacaaaaaaggguuuuuaauacugaccuacuacuucaagggcaguuc
ugaggugauuagagcuuuuuuuaaaaaccaaguauuuggggauccucagcagagguauucauacagacucccaaagaacua
uauauguuccugagaccaucguuuagucuacauugcucuucccagagacugacagauaugaccagucaaagugcaagacua
ccuacccacugcaugaaaaccauugcaggaaaccuuucccuuccugaaugagauuuuuuuuuucccuuuuuaugugggg
uaauuauuugugacuaaguguaauuuggaugauuuccauuaauaucaacucuugaagccuacuuguacugauugagauu
guauuuguuccuaauaaaaguggaucugguuguacuguc
12 V00756 accacuugcagacaaaugaauuccuucgaaauguauuugagguuggacccccugugaugcu
unugcugcaacacuuaaaaccauguauauuucucguuuugaaaggcauuuauauaacucu
gcagcuuucaaagcucgaacaaaagcucgaagcaaaugccgagauaagagagcagauguugg
agaauucuuguagaugucugaauuugauggcuguuuucuaaucucuuccuuuauuauuau
uuuugcuacuucuaauuuauauaagcuuuuagugacaguuuuuggaucuuggucaacuuaaa
uaauuuuugauguaggggguggguuguauuuuaauuuaauguacaguguuacaaauuaaug
aguucuuuauucucuguaaaaauaacugguaaccacaaauaaaguguuugugauguuuggu
cgu
13 Y14296 auguccgcggccgccuacauagacuucauggcugcccagugucugguuuccaucuccaacc
gcgccgccgugccggagcacgggggcgcuccggaagccgagcggcugcgacuaccugagcg
cgaggugaccaaggaacacguugacccgggggacaccuggaaggauuauugcacgcugguc
acuaucgccaagagcuuguugggaccucaacaaauaccgacccauccagacccccucuugug
cagcgacagucuggagagucccgaugaggauauaggauccgacagcgacgugaccaccgaau
cuggucgaguccuucccacagcccggaugagagacaguauucuggcagcgcgcccagccca
cucucccuccuccacucuagaguagcuucgaaggauaaacacggccuccaaaaaaaggcacaa
gugccccuacaguggcugugggaaagucuauggaaaauuccucccaucuuaaagcccauuaca
gagugcauacaggugaacggcccuuucccugcacguggccagacugccuuaaaaaguucuc
gcgcucggaugagcugacccgccacuaccggacccacacuggggaaaagcaguuccgggggcc
cacugugugagaagagauucaugaggagugaccaucucaccaagcaugcccggcgucacacc
guguuccaucccagcaugaucaagagaucaaaaaaggcucuugccugccccuugugaggug
cuccccaugucagccaggcagagauggguccccggaaggacagaucucccaggaaacagacu
gacacauggggaaaucugccacagcagaggcacgcuggccacagggagggucacugcuucuuugg
ccaauauucugauaucucccugcacuguuuccaaaaagcacaugguagcccuaaggucaaag
ucaacaugggugguccccuugcagagucaacucugaaccgucucugacugaagauucagacug
gugguuuuacauacgucuuacugauugagguugaccccuauccucccacaaugcagaaccacu
cucuugaaucacauuaacuuuugagagguaaaaaaaacccaaacccaacccguucaaaacucca
gauacaccgaaacucuggauccucuaugcugggcugacucucagaauuguuuuuucuucuca
uuaugcaagcuaggagcacaccuacuccaacaugauuugucaucuaaagacuuggaaaacaaa
acaacaacaacauaaaguuacuuauagucaauggauaagcagaguccgaauuuaca
aagacagaccuucgaggggucacgauaaguccggaacuuucaaaccuugcuucguaugaau
uguacuaucuggaacauaaacuacacuuuuauuguucuaauaccgagauugaauacgguaaau
acaugcuuugaggguagaauccgacggucuguuuggcaccacguuauaaucugcuuuuu
uaacgaguaccaccuuggagggcaggcaaauaaaugcuuuuggguauuuucuccuuugugg
uugacaaauacugcggauggggggaucaggaucggaggggagugcuggggaaagauaauaaaa
aaugagguaaauaauuuuaacuuaugaauuuguuugaauuc
14 X16490 gagauugaaacaauggaagaacuuuccaucacaaacaccauguuuacccucaaucuccuu
gagauugaaacaauggaagaacuuuccauggcaaacaccaugugggcccucaaucuccuu
aagcagauagaaaaaucaaacucuacccagaacaucuuuaucucuccauggagcaucuca
ucaacauuggccauaguucuccucggugcuggggguaacacugaacagcagauggccaaa
gugcugcaguuuaaugaaauuggcaguuaugguaucaccacaagaaacccagagaacuuc
aguggcugugauuucgcacaacagauacagaaggaaaauuauccuagugcuauuuuacagg
cacaagcaggagauaaaauccauucagccuucuccucucucagcucaacaaucaacaca
ccacagggggauuauuuguuagaaagugcaaacaagcuguuuggagagaagucugcaagau
ucaaagaagaauacauccaacucucuaagaaauauuacucaacagaaccagaagcagug
gacuuccuugaaugugcugaagaagcuagggaaaagauuaauucuugggucaagacucaaa
ccaaaggugaaaucccaaaccugcuacccgaagguucuguagaugaagacaccaagauggug
cuggugaaugcugucuacuucaaaggaaaguggaaaacuccauuugagaagaaacuuaaug
ggcuuuauccuuuccgugugaacucgcaugagagcauaccuguccagaugauguuccucca
ugcaaagcugaacauuggauacauaaaggaccugaagacucagauccuagaacuuccgcaua
cuggaaacaucagcaugcuccuguugcuucccgaugagauugaggacgcauccacuggcuu
ggaauugcuggaaagugaaauaaacuuugccaacuucaacaaguggaucagcaaagacacac
uggaugaagaugauguuguggucuacauucccaaguucauacuggcacaaagcuacgaacu
caaguccauucuucaaagcaugggcauggaggaugccuucaacaagggcaaggccaacuucu
caggaaugucugagaggaaugaccuuuuucuuucugagguguuccaucaagccagcgugga
ugucaccgaggagggcacuguggcagcuggugggacuggggcaguuaugacaggaagaacu
ggccaugguggcccacaguuuguggccgaucaucccuuucuuuucuuuaucauggacaaaa
uuacccacacgauacuauuugaugguagauucuccucacccuaaaaggggaagaccuauuu
ccacaugagguuuuguagcaugaacuauaagccucagaauugcaucuucaagugccaaaag
uuuaaauacuuucuuacacauuuuuauacuucugcuauacacuaaauauaaccuaaaagcaa
uuguauagcagucuucagugcuuacaguauaacucuauuaaugauuuuguuuccuaaaguc
agaugaugucuauuuaguucauccuuauuacugcuuugucuuuauaacuuuaguuuuuac
aguguuauuuauuguuuauauaaugguuguuuuacuaauuguuguccucuguuaaugaa
acuguaacacuacagaagcagaaaauuagauaauuucuauuuaaagaaaaucagccauuua
auuuaauaaugaaggaaaaauaugagucuuccauacuuucccaugauauucacccagaaaaa
auguacuuaacaaaagacauguuauaucucuaucauuauauaucauauguacguaucugca
acucaucuauaauuaggacuacaucauaaguaagcaugcuuacuuacacacugcuaucuguu
guauaaaacuuagcaauccuuauuuguuaguuaucuuucuaucacuguaacaaaauaccug
auauaauaaaguucaaagauuuauuuugaaaaaaaaaaaa
15 AW120868 uunuuuuuuunuuuuuuuaagaauuaacuunuauunuugcuuaguuuuauuaaaaaaauua
auaugucauaaagcuuuuguuuccuuuagggagaaaaaaaaggaacaaguuccauaaaauca
aacaagcaaugguaacaugucuuaacuugaaaacaacuggggucacugguuuacaaguuau
aacugaaugaaugacugccacaguugcccauuuccuccugccaauggcagcaaacaacagga
ucaacuagggcaaaauaaauaauuguguggaagcccuga
16 C78850 aacuaaacuuccuuguaacuuuugagaacucagcucugguacuuuuucaugccuugcaaaa
uggcguuanugcagcuagcuugcuaanccuuaugguggggucuuucauuccccccucuuu
cuggaaacuguauaaaaucauuuuucacgugauucuauuucuucuggaucuauugauuug
aguugguuauacuguugggucanaaccagggccuguu
17 D67076 Sequence below.
gcagcuccgagcuaggugcuaucgcaagcccagagcgcacagcccggcggagagagcagauccuugcucagaucgagucaa
aucgggccaaggcggaggacgaagaguccaggcuccuauucuggacuuguuccccagcuccgggggcgcuucuagguccu
gcagcagccagcagugcguagccaccaacucggugcuggaaugaaaaaauucccgcgcgccagugcagaaucuuucuaagu
gacccggagcuucgggugcuagcucugcacgaacuuucccaucaaagugaucgugaauuuuaagcaucaggagcaggccag
cgaagcucuacgcgucuaaacgucuauccagaccaagaguucucugcggugcagggugcggugccaugcagccaaaagucc
cuuuuggggucacgcaagcagaagcccugcuccgacaugggggacguccagcgggcagcgagaucucggggcucucuguc
cgcacacaugcuguugcugcuccucgcuuccauaacaaugcugcuaugugcgcggggcgcacacgggcgccccacggagga
agaugaggagcugguccugcccucgcuggagcgcgccccgggccacgauuccaccaccacacgccuucgucuggacgccuu
uggccagcagcuacaucugaaguugcagccggacagcgguuucuuggcgccuggcuucacccugcagacuguggggcgca
gucccggguccgaggcacaacaucuggaccccaccggggaccuggcucacugcuucuacucuggcacggugaacggugauc
ccggcucugccgcagcccucagccucugugaaggugugcguggugccuucuaccuacaaggagaggaguucuucauucag
ccagcgccuggaguggccaccgagcgccuggccccugccgugcccgaggaggagucauccgcacggccgcaguuccacauc
cugaggcgaaggcggcggggcaguggcggcgccaagugcggcgucauggacgacgagacccugccaaccagcgacucgcga
cccgagagccagaacacccggaaccaguggccugugcgggaccccacgccucaggacgcgggaaagccaucaggaccaggaa
gcauaaggaagaagcgauuuguguccagcccccguuauguggaaaccaugcucguagcugaccaguccauggccgacuucc
acggcagcggucuaaagcauuaccuucuaacccuguucucgguggcagccagguuuuacaagcaucccagcauuaggaauu
caauuagccuggugguggugaagaucuuggucauauacgaggagcagaagggaccagaaguuaccuccaaugcagcucuca
cccuucggaauuucugcagcuggcagaaacaucacaacagccccagugaccgggauccagagcacuaugacacugcaauucu
guucaccagacaggauuuauguggcucccacacgugugacacucucggaauggcagauguuggaaccguaugugaccccag
caggagcugcucagucauagaagaugaugguugcaagccgccuucaccacagcccaugaauugggccauguguuuaacau
gccgcacgaugaugcuaagcacugugccagcuugaauggugugaguggcgauucucaucugauggccucgaugcucucca
gcuuagaccauagccagcccuggucaccuugcagugccuacauggucacguccuuccaagauaauggacacggggaauguu
ugauggacaagccccagaauccaaucaagcucccuucugaucucccgguaccuuguacgaugccaaccgccagugucagu
uuacauucggagaggaauccaagcacugcccugaugcagccagcacauguacuacccuguggugcacuggcaccuccggug
gcuuacuggugugccaaacaaaacacuucccuugggcagauggcaccagcuguggagaagggaaguggugugucaguggc
aagugcgugaacaagacagacaugaagcauuuugcuacuccuguucauggaagcuggggaccauggggaccguggggaga
cugcucaagaaccuguggugguggaguucaauacacaaugagagaaugugacaacccagucccaaagaacggagggaagua
cugugaaggcaaacgaguccgcuacagguccuguaacaucgaggacuguccagacaauaacggaaaaacguucagagagga
gcagugcgaggcgcacaaugaguuuuccaaagcuucuuugggaaugagcccacuguagaguggacacccaaguacgccgg
cgucucgccaaaggacaggugcaagcucaccugugaagccaaaggcauuggcuacuuuucgucuuacagcccaagguugu
agauggcacucccuguaguccagacucuaccucugucugugugcaagggcagugugugaaagcuggcugugaucgcauca
uagacuccaaaaagaaguuugauaaguguggcguuuguggaggaaacgguuccacaugcaagaagaugucaggaauaguca
cuaguacaagaccuggguaucaugacauugucacaauuccugcuggagccaccaacauugaagugaaacaucggaaucaaa
ggggguccagaaacaauggcagcuuucuggcuauuagagccgcugaugguaccuauauucugaauggaaacuucacucug
uccacacuagagcaagaccucaccuacaaagguacugucuuaagguacagugguuccucggcugcgcuggaaagaauccgc
agcuuuaguccacucaaagaacccuuaaccauccagguucuuaugguaggccaugcucuccgacccaaaauuaaauucaccu
acuuuaugaagaagaagacagagucauucaacgccauucccacauuuucugagugggugauugaagaguggggggagugc
uccaagacaugcggcucagguuggcagagaagaguagugcagugcagagacauuaacggacacccugcuuccgaaugugca
auggaugugaagccagccaguaccagaccuugugcagaccuuccuugcccacacuggcaggugggggauuggucaccaugu
uccaaaacuugcgggaaggguuacaagaagagaaccuugaaaugugugucccacgaugggggcguguuaucaaaugagagc
ugugauccuuugaagaagccaaagcauuacauugacuuuugcacacugacacagugcaguuaagaggcguagaggacaag
guagcguggggaggggugauacacugagugcaagaguacuggagggauccagugagucaaaccaguaagcagugaggug
uggcaaggagguguguguaggggauacauagcaaaggagguagaucaggacacuacccugccaguuacauucugauaagg
uaguuaaugaggcacaguagcaucugaaagaccauacagagcacuaaggagccccaaagcacuauuaguaucucuuuucuu
auaucuaucgcccaaauaauuuucagagucuggcagaagcccuguugcacuguacuaacuagauacuucuuaucacaauga
uugggaaaggcaaagcagaaagaugguaagacuggguuucaaacaaggcuugguuucaaucacuggaggcaaggaggagg
18 M61007 ccgcgggcccgcguucaugcaccgccugcuggccugggacgcagcaugccucccgccgcc
ccgcgggcccgcguucaugcaccgccugcuggccugggacgcagcaugccucccgccgcc
gcccgccgccuuuagacccauggaaguggccaacuucuacuacgagcccgacugccuggc
cuacggggccaaggcggcccgcgccgcgccgcgcgcccccgccgccgagccggccauugg
cgagcacgagcgcgccaucgacuucagccccuaccuggagccgcucgcgcccgccgcgga
cunucgccgcgcccgcgcccgcgcaccacgacuuccucuccgaccucuucgccgacgacua
cggcgccaagccgagcaaagccggccgacuacgguuacgugagccucggccgcgcggg
cgccaaggccgcgccgcccgccugcuuuccgccgccgccucccgccgcgcucaaggcgga
gccgggcuucgaacccgcggacugcaagcgcgcggacgacgcgcccgccauggcggccgg
uuucccguucgcccugcgcgccuaccugggcuaccaggcgacgccgagcggcagcagcgg
cagccuguccacgucgucgucguccagcccgcccggcacgccgagccccgccgacgccaa
ggccgcgcccgccgccugcuucgcggggccgccggccgcgcccgccaaggccaaggccaa
gaagacgguggacaagcugagcgacgaguacaagaugcggcgcgagcgcaacaacaucgc
ggugcgcaagagccgcgacaaggccaagaugcgcaaccuggagacgcagcacaaggugcu
ggagcugacggcggagaacgagcggcugcagaagaagguggagcagcugucgcgagagcu
cagcacccugcggaacuuguucaagcagcugcccgagccgcugcuggccucggcgggcca
cugcuagcgcggcgcgguggcguggggggcgccgcggccaccgugcgcccugccccgcgc
gcuccggccccgcgcgcgcgcccggaccaccgugcgugcccugcgcgcaccugcaccugc
accgaggggacaccgcgggcacaccgcgggcacgcgcggcgcacgcaccugcacagcgca
ccggguuucgggacuugaugcaauccggaucaaacguggcugagcgcguguggacacggg
acuacgcaacacacguguaacugucuagccgggcccugaguaaucaccuuaaagauguuc
cucgggguuguugauguuuuugguuuuguuuuuguuuuuuguuuuguuuuguuuuuu
uuuuuggucuuauuauuuuuuuuguauuauauaaaaaaguucuauuucuaugagaaaaga
gg
cguauguauauuuugagaaccuuuuccguuucgagcauuaaagugaagacauuuuaauaa
acuuuuuuuuauaauuuuaaauccaaaaaaaaaa
19 C85523 aaaauguagaaggcaagauuuaauaaggcagcaacaugaaagcacacagaccagagcucu
ggggucgaaauaaagcagcaacauggaagcacacagagcucuggggucgaaacucauaca
ccuuagcacaggguagaggagucucgacggucauccagaauuuuucacaggcuuauauag
uaaaacucaaagggggagaacugggcagggaaaguacaaguuuacancacuagggaguuc
ugccaaaggacaauggguucuuucagaggaaucuacguaacuaaggugucauguccuauc
aagguaucuacguaacuaaggagucauguccuaucauuuggcaauguacccgguucuuuu
gagguuguuccggagggucaauucucaaaauguuuuucagauuggaagggguggguguc
cgguaaaaaguucuguuuucaaagaggcnguaauuuucuauucuucauuccccauucucc
uguaaguauucnnaucuuagaauuucagaaguccauauucncuauguggggaauaacugg
cuuuaacccnaucuuuaaaauggggg
20 AW122030 uuuuuuuuuuuuuuuaugaaacaguuuuguucngcccaugacugugcaugacuguc
guccguucuagucaccugugcucuccaucuacugccuuuuaaagcugcgucaugagaagg
aucuacacguuccaccaugacucucguuucuugccacaaguagaagaaaugguugauucu
uggcuuuucgguuaggccguuaaacaaaacucagucacaccccugccuuccacccucaaa
cugugaucacguggcuguucuuguaguunaaccagggcaacacuauauauuccaggucua
uacauucuaggucuuuuucuguuuuguucauuauaguguuuucaaccucguuccg
21 1557524 Sequence below.
gcggccgcggcuccagaccccggccuugcgcacccuccccccaccuccagcccgcgccucccccccccccacgcauggcucac
caccccucggguuucccugucaucccucagguuccugcacuuggcaaucauccacgaagagaagccgcugaccauggaagu
cauuggucaggugaagggagaccuggccuuccucaacuuccagaacaaccugcagcaggugcgcugcuugcuugccccgcg
gugccccucuuugaccccuugguggagucagauguggcacggucgcccccaaagcguuucuaaauuaauagucacuuaguu
cuuaucugccuuggcuuuuuugcauucaaaucagccaacgucuuagaaccagaagaaaaaucccuugguuuuagugagguc
uuuaugacccaccuagggccuccuguuugccugaucuccuaagagacuaaugggaggaucagauuccauagcgggaggug
ucugggguucaggaaacucaagacuauggguuugcuccauggcuuaucccuucuguuccucuuuccauuugagacucc
acuccacuuggcugugaucaccaaccagccaggaaugcugaggcacuucugaaagcuggcugugauccugagcuccgaga
cuucgaggaaauaccccucuacaucuugccugugagcagggcugccuggccaguguagcagucuugacgcagaccugcac
accccagcaucuccacuccguccugcaggccaccaacuacaaugguaggucugccaguccauccaaggaugcagaggaggga
gagagauggggccacuugagucuuaaacuccgaacguauacaaaguucagacacugugaucuuuuuuaaaaaguuuucuccu
cgaugccuauaugauauucacucagaacccagauucugaguucuucaaaacugaugaugugggugguuguccucaagacaa
uagacaugaguugugugaggauugaaacacguaguacaguuuuugucuccuccuccaggccacacgugucugcaccuag
ccucuacucacggcuaccuggccaucguggagcacuuggugacuuugggugcugaugucaacgcucaggugaguacaucu
cccuuccaccuaaucucuguugggcuggcucugauggugagcagguuuccagaugcagccguaaacuaacgccugauugc
uuuugguuucaggagcccugcaauggccggacagcccuccaccuugcgguggaccugcagaauccugaccugguuucgcu
cuuguugaaauguggggcugaugucaacaggguaaccuaccaaggcuacucccccuaccagcuuaccuggggccgcccaag
uacccggauacagcagcagcugggccagcugacccuggaaaaucuccagaugcuacccgagagcgaggaugaggagagcua
ugacacggagucagaauucacagaggaugaggugaguguuccuccccucagcacgcugacggcuguucuagggcugcuuu
ggaucagagggauuucagggguuuaacuucucagacucggcuugcaaagcaggaucccaagaauugucucugguuuguu
uuaagagcuuacccuuuugguugaggaaugagggaauucuagaaauugaacccaggcuuagcacauggugauaagcacac
guuaccauuaagcuccacccccucaauagcuuagacuuuuuuuuuuuuuaaggaaagaauagguaagggaaacuccuac
agccuggugcccuuguucuauuuggguuaaggagaaaaagagcccaagaauaggaguuauuucagcagcagcucuccccuu
aucccauugucuuggugaaguucuaggaauuuauaugucuuuuuccccucucuuguuuuagcugcccuaugaugacugu
guguuuggaggccagcgucugacuuauaaguggaaaguggcaaaaaagaauguggacuuguauauuuguacaaauagag
uuuuauuuuucuaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaguauacuuagcaccacaccacacagcgccuagaccc
aggcauuuuacuggggugaucggcuguugucuugugaaauccgggg
22 U05809 cucucggucacugccggucgcuuccugagccgcugcuggcucugugucucuguccucagc
guucucuuccucguccucguccuaccacgccauggaagguuaccauaagccagaucagca
gaagcuccaggcccugaaggacacagccaaucgccugcgcaucagcuccauccaggccac
caccgcggcaggcucaggccaccccacaucaugcugcagcgcugccgagaucauggcugu
ccuguuuuuccauaccaugcgcuacaaggcccuggauccccgaaacccucacaaugaucg
cuuugugcucucuaagggccaugcagcuccauuuuauaugcagucugggcugaagcugg
cuuccugcccgaggccgagcugcugaaccugaggaagaucagcucugacuuggacgggca
uccugucccgaaacaagccuucaccgauguggccacuggcucccugggccagggccuggg
agcugcuugcgggauggcauacacaggcaaauacuugggacaaagccagcuaccgagucua
uugcaugcugggagacggggaggucuccgagggcuccgucugggaggccauggccuuugc
uggaauuuucaagcuggacaaccucguugccauuuuugacaucaaccgccugggccagag
cgacccagccccgcugcagcaccagguggacaucuaccagaagcgcugugaggccuuugg
cuggcacaccaucaucguggacggacacagcguggaggagcugugcaaggccuuugguca
ggccaagcaccaaccaacagccaucaucgccaagaccuucaagggccgagggaucacagg
gauugaagacaaggaggcguggcacgggaagccccuccccaaaaacauggccgagcagau
uauccaggagauuuacagccagguucagagcaaaaagaagauccuggccacgcccccuca
ggaggaugccccauccguggacauugcuaacauccgaaugccuacgccacccagcuacaa
agugggggacaagauagccacccggaaggccuauggacuggcccucgcuaagcugggcca
cgccagugaccguaucauugcccuggauggagacaccaagaauuccaccuucucggagcu
cuucaaaaaggagcacccagaccgguucauugagugcuacauugccgagcaaaacauggu
gagcauugccgugggcugugccacacgugaccggacagugcccuucugcaguacuuucgc
ggccuucuucacacgggccuucgaccagauucgcauggccgccaucucugagagcaacau
caaccucuguggcucccacugugguguguccauuggggaagacgggcccucucagauggc
ccucgaagaccuggccauguuccggucaguccccauguccaccgucuuuuacccaagcga
uggaguugcaacagagaaggcaguggaguuagcagccaacacaaagggcauuugcuucau
ccggaccagccgcccagagaaugccauuauuuauagcaacaaugaggauuuccaggucgg
ccaagccaaggugguccugaagagcaaggaugaccaagugacagugaucggggcuggugu
aacucugcaugaggccuuggcugcugcagagagucuaaagaaagauaagaucagcauccg
ggugcuggaucccuucacuaucaagccccuggacaggaaacucauccuagacucugcccg
agcaaccaaaggcaggauccucaccguggaggaccacnacuacgaagguggcauaggaga
ggcagugucugcugccguagugggugaaccuggagugacggucacucgccuggcugucag
ccaaguaccacgaaguggcaagccagcugagcuacugaagauguucgguauugacaagga
cgccauugugcaagcugugaaaggccuugucaccaagggcuagggagggcaugggaugcu
gggugggugaacuacacauuccagggagguucuggcagagguggcgaagguguacugagu
ggggagguaaauauauguuuug
23 AW212475 uuacggugucauaaauaaguaauauaacuuuauuaaaaugaaaagacaauauucaaaau
aaugcaacaaaaugaauaaauccuuuguccaauacuguacacacagugcggagaucagug
cauuuucuaaagcauguuuuaaccuucauuuaguucauacuaaaguaagcuuuaaauag
cucaaauaauuucauucagcaguuuaaacugaacagcuuuuuacau
24 V00835 uguguucucguaaucuccagagcagcguuaggccguauuaucggggaaagcacuauaggg
acaugauguuccacacgucacaugggucguccuauccgagccagucgugccaaaggggcg
gucccgcugugcacacuggcgcuccagggagcucugcacuccgcccgaaaagugcgcucg
gcucugccaggacgcggggcgcgugacuaugcgugggcuggagcaaccgccugcugggug
caaacccuugcgcccggacucguccaacgacuuaaagagggcaggcuguccucuaagc
gucaccacgacuucaacguccugaguaccuucuccucacuuacuccguagcuccagcuuc
accagaucucggaauggaccccaacugcuccugcuccaccgguaagacucccgauccuug
gcuuuagaauaccaaguugggaccgcagagcggaauccccgaguuguagaggcuuggcg
ggaauaggcaccuuuaguuggcgauucauuccgguucuuucuagaauccgcucuugcaaa
agccuucauuaguuacgaguauuggaacggguccuuuggcgggguuggggcuaggauu
uagacgcgcaaauguccgguuccugaucacccaguuaguggggacaucuggguugagucc
caggcauuacuaaacuuacugugaauugcuugaauuaagaaagaggugaaggaccuuuau
gucuugggacucaaagacauaaucccugacuuaaccugugaggagaaaaguggggcuagg
cucccugcagcuccgaggaggacggagugaacugagccgggacucgugguguuggccacu
gcuguaaugcugccucccucaugcugucuucuuucuccucccaggcggcuccugcacuug
caccagcuccugcgccugcaagaacugcaagugcaccuccugcaagaagagugaguuggg
acaccuuggguggcggcuaaggcuaggggcggggaacuccuacaaaacuggcucugagaa
auguccggggcuucccggaggccauuguauugucucggggacagaacuauacagagaacu
auaaaaaaaccgaggucuucucuguuggggacaggaagcagaggucuucagccaggcu
gccucuuccuccuucuucuaggcugcugcuccugcugucccgugggcugcuccaaaugug
cccagggcugugucugcaaaggcgccgcggacaagugcacgugcugugccugaugugacg
aacagcgcugccaccacguguaaaguaucggaccaacccagcgucuuccuauacaguu
ccacccuguuuacuaaacccccguuuucuaccgaguacguuaauaauaaaagccuguuug
agucuaacucugguuucuuggugugguuuggcaauaagaaacuggggugacuugauaguc
uggggaucugguuuuggacccccucgugccuuuaccuccgcccucuggcccucacagagg
gguaaugucuuuggguaaagccaagcuauaucccauaagcuuccucauggaaaacagcug
25 AV374868 gcggcacgaguguccggguggcuuuuuuuuuuuuguuugaauaauguuuacaauuu
cccucaaucacuuauagaaauccaccuccaggccccccccuuccccacuaggccuu
cgaggcugucugaagaugcuugagaaacucaaccaaaucccaguucaauucagacuuugc
acauauauuuauauuuanaaucagaaaagaaacauuucaguaauuuauaauaaaagagca
cuauuuuuuaacg
26 M21285 See above (same Accession Number).
27 U74683 acugccaucgagugguguuccaguugaacuugcucucucugccaucugcuccgcgggcgc
cgucagcaugggucccuggacccacuccuugcgcgccguccugcugcuggugcuuuggg
agucugcaccgugcgcuccgacacuccugccaacugcaccuacccugaucugcugggcac
cuggguguuccaggugggcccuagaaguucccgaagcgacauuaacugcucggugaugga
agcaacagaagaaaagguagugguacaccuuaagaaguuggauacugccuacgacgagcu
gggcaauuccgggcauuuuacccucauuuacaaccaaggcuucgagauuguguugaauga
cuacaaaugguuugcguuuuucaaguaugaagucagaggccacacagcuaucaguuacug
ccaugagaccaugacuggguggguccaugaugugcugggccggaacugggcuugcuuugu
uggcaagaagguggaaagucacauugagaagguuaauaugaaugcagcacaucuuggagg
ucuccaggaaagauauucugaaagacucuacacucacaaccacaacuuugugaaggccau
caauaccguucagaagucuuggacugcaacugcauauaaggaauaugagaaaaugagccu
gcgagaucugauaaggagaaguggccacagccaaaggaucccaaggcccaaaccugcccc
gaugacugaugaaauacagcaacaaauuuuaaauuugccagaaucuugggacuggagaaa
cguccaaggcgucaauuauguuagcccuguucgaaaccaagaaucuuguggaagcugcua
cucauuugccucuauggguaugcuagaagcaagaauucguauauuaaccaacaauucuca
gacaccaauccugaguccucaggagguuguaucuugcagccccuaugcccaagguuguga
ugguggauucccauaccucagcagggaaguaugcccaagauuuuggggugguggaaga
aagcugcuuucccuacacagccaaagauucuccaugcaaaccaagggagaauugccuccg
uuacuauucuucugacuacuacuauguggguggucuaugguggcugcaaugaagcccu
gaugaagcuugagcuggucaaacauggacccauggcaguugccuuugaaguccacgauga
cuuccuacacuaccacaguggaaucuaucaccacacugggcugagugacccuuucaaccc
cuucgagcugacaaaucaugcuguugcuugugggcuauggaagagauccaguuacugg
gauagaauacuggauuauaaagaacagcuggggcucuaacuggggggagaguggcuacuu
ccguauccgcagaggaacugaugaaugugcaauugagaguauagccguggcggccauacc
gauuccuaaauuauaggacauagcucccaguguuacauacgggucuuuaucacucacaga
gugauagucacaugcugaagacuuuuucagagcaauaucagaagcuuaccacuaagca
ucuuuaaagaauugucuuugaacuuaaaaccauccuugauuugguuucuuuuaauaucu
uccccaucaacuacugaacuacuuuucuuuaaagacuugguuaaguaauacuuuuau
gagcagugguucaguuguccaauaugggguugcaggucaucuacaaugcaaccagauguuu
caguucuaaaaaucuauguaaaaguacaagcucguuuuuaaauuauguaagucacaugaa
aacauggcaaaaaaauuaguuaaauuuuuuacaaagaguuuuaaauaaauguuuauguaa
ucaguaccauagucuuucuauguguguacaugaauuuuugucaccuacuucuucccuu
agaagcauuuaugcuccauggacguacuucuuuauggagaaaaaaaaaa
28 X61800 gagcucgaucccuguuccgccuuugcuaugucugaaggcguuccugcuuugcgcgugucgg
ggccaaauccagauuuucauuucgcuccaggcuuggacggcuaaguagguccaaaccgca
caaacaggaaggagggaaggcaaggagugcgggcagagggcgggucguucccagcagcac
cccagucccuccccgcuccgucuccgacccacuggggccggggcgggcgugcgcgucagc
uggggcuagaaaaggcggcgguccggcccggcgaggugacagccaacuuggacgccaggu
ccggccgacgccgccaugagcgccgcgcuuuucagccuggacagcccggugcgcggcaca
cccuggcccacagaacccgcggccuucuacgagccaggcaggguggacaagcccggccga
gggcccgagccaggggaacugggggagcugggcuccacgacuccugccauguacgacgac
gagagcgccaucgaccagcgccuacauugacuccauggccgccgugcccacccuagag
cugugccacgacgaacucuucgccgaccucuucaacagcaaccacaaagcggccggcgcg
ggcggccuggagcugcugcagggcggcccuacgcgacccccggguguggggucugucgcu
agggggccgcucaagcgcgaacccgacuggggcgacggcgacgcgccgggcucccuccg
ccggcgcaaguggcggugugcgcgcagacaguggugagcuuggcggccgcggcucagccc
acuccacccacuucgccggagccuccucgaggcagcccggggccgagccucgcgcccggc
acaguccgagaaaagggcgcgggcaagagggguccggaccgcggcagcccggaguaccgg
cagcggcgcgagcgcaacaacaucgcugugcgcaagagccgcgacaaggccaagcgccgc
aaccaggagaugcagcagaagcugguggagugucggccgagaacgagaagcugcaucag
cgcguggagcagcucacccgggaccuggcuggccuccggcaguucuucaaaaaacugccc
agcccgccuuuccngccgcccaccggcgccgacugccgguaacgcgcggcgugggccuuu
gagacucugaacgaccuauaccucagaccccgacagcggggagcagacgccgcccgaauc
gcuaguuucuuugggaccugcgagcgacaggaagcugcagcuugggcacuggacugcgag
agaagcuauuaaucuuuccccuuaaauuauuuuuuauaaugguagcauuuucuacguc
uuauuaccaugcagcuaagguacauguagaaaagacauuuccgacagacuuuuguag
auaagaggaagagacugcgcaugcuuuuuauauucauuuuuacaguauuuguaugauuaa
caauaacaauaaaaaaacauuuaaaucgcaaaaaaaaa
29 U20735 Sequence below.
uugaggguggccaggccagcguaggaggccagcguaggauccugcugggagcggggaacugagggaagcgacgccgagaa
caggcguaccacggagggagagaaaagcuccggaagcccagcagcgccuuuacgcacagcugcaacuggccgcugccga
ccgucuccagcucccgaggacgcgcgaccggacaccggguccugccacagccgaggacagcucgccgcucgccgcagcgagc
ccggggcggcccuucagggggaccuuucccagaucgcccaggccgcccggaugugcacgaaaauggaacagccuuucuauc
acgacgacucuuacgcagcggcgggauacggucggagcccuggcagccugucucuacacgacuacaacuccugaaacccac
cuuggcgcucauccuggcggaucccuaucggggucucaaggguccuggggcgcgggguccaggcccggagggcagugggg
caggcagcuacuuuucgggucagggaucagacacaggcgcaucucugaagcuagccuccacggaacuggagcgcuugaucg
uccccaacagcaacggcgugaucacgacgacgcccacgccuccgggacaguacuuuuacccccguggggguggcagcggug
gagguacagggggcggcgucaccgaggagcaggagggcuuugcggacgguuuugucaaagcccuggacgaccugcacaag
augaaccacgugacgccccccaacgugucccugggcgccagcggggguccccaggccggcccagggggcgucuaugcuggu
ccggagccgccucccgucuacaccaaccucagcaguuacucuccagccucugcacccucuggaggcuccgggaccgccgugc
ggacugggagcucauacccgacggccaccaucagcuccucccacaugcaccacccuuuguccuugaagaagggacuca
ggguuugagucguggcgcuuccgccuuuaaugaggaaccgcagaccguaccggaggcacgcagccgcgacgccacgccgcc
ugugucccccaucaacauggaagaccaggagcgcaucaaaguggagcgaaagcggcugcggaacaggcuggcggccaccaa
ggccggaagcggaagcuggagcgcaucgcgcgccuggaggucaaggugaagacacucaaggcugagaacgcggggcuguc
gagugcugccggucuccuaagggagcaaguggcgcagcucaagcagaaggucaugacccaugucagcaacggcugccaguu
gcugcuaggggucaagggacacgccuucugagagccucccuugccccauacggacacccccagccuugaaggcugggcgcc
ugccccccacuggggugaggggggcaggcgaugggcacccgccaaaaggccuggggcgcagcucacacacuggacuccggc
ccgcccgccugcgcccaguccuuccaccucgagguuuacauggcccccuucagcguauuuuguauguuuuuuuuuucug
caaagagacugaauucauauugaauauaauauauuuguguauuuaacaggagggagaagggggcugucgcggcggagcug
gccgccgcagguacucagcugcggggauacuagggagggaccuccgcccccugcccucccccucugcauaguacugug
gaagaaacacgacuucgugucuaaagucuauuuuaagauguguuuguguguguguguuugacuuuuuauugaaucuauu
uaagua
30 U19118 Sequence below.
gaauucggcacgagcagcgagacgccgcgcacggugcuuccccaguggagccaaucggcuaacccgcgcuccggcagaguc
cuuggcgcucgcccgccggcgggacagaccacccgccucuggccgcucucuggacccuggccgccccgagcgaagacugga
gcaaaaugaugcuucaacauccaggccaggucucugccucagaagucagugcgaccgccauuguccccugccucucaccucc
ugggucacugguauuugaggauuuugcuaaccugacacccuugucaaggaagagcugagauucgccauccagaauaaaca
ccucugccaucggauguccucugcgaggagucaguuaccgucaacaacagaccccuggagaugucagucaccaagucuga
ggcggccccugaagaagaugagaggaaaaggaggcggcgagaaagaaauaaaauugcugcugccaagugucgaaacaagaa
aaaggagaagacagagugccugcagaaagagucagagaaacuggagagugugaaugcugagcugaaggcccagauugagga
gcugaagaaugagaaacagcaugauacaugcucaaccugcaccggcccaccuguaucguccgggcucagaauggacg
gacaccggaagacgagaggaaccucuuuauccaacagauaaaagaaggaacauugcagagcuaagcagagguggcacggag
gcaauuggggaguucuuacugaauccuccuuuccaccccacacccugaagccauuggaaaacuggcuuccugugcacuuc
uagaaucccagcagccaagagccguuggggcaggagggccuguggugaccuacugcauugacccacucugcccccgaguga
accguggagcaggcaggagcauccuuugucucaccaauuccaggauuuaggccuuaucaucccggccagucucagaugacc
uagcuggccccaggcugggguccuaugcaaagcaggaucccacuaaugggauucaggcagaagugucuaccuugauaggu
ggggugggaccacauccuccacuguggcgacaacgcccuuccaagggaauauggaaugagaacauucauuauugagguug
uccaauggccaggguaugcuuucuagaaaauaugcuguucugucccagaaugacugugcauaggguauccguuucagagc
cuggguugugcuauuuagauguuugucuugcacaacauuggcauggaacggaagacccacagagaccaggcaacgag
gagagucuggggaucugccaugguggaaagugccccucaaaagcauuuguguggccacaugaacuggcuggcaccagggg
agugaaacuggcugaugaccagcugagccacuuugugccaacagaggauggacgacaccuuucccuguacccacugcagag
gaagaacccugggcacagcagcuuuguccuuggcuacacuguuacaacgucacacaaugauggcacaguccaacuuuc
aaaggguguaggacuccauacucagugacagggcaggaagagccaaagauaaccacagccacagccuguggagaccagggu
uggaagccaggugcagggccaggcaucugcauugugggauguuaauggcacuuuugucuuguagcuauuuugagaugug
guccagagcauuucagcugggagaucuccccuggccaccaggacucuggcuacuguuaaaauccugauguuucugugga
auccucaguguuuuaucccacucaauaguaucauuacaguuucuguaagagaaaauauuacuuauuuaucccaguauucc
uagccugucaacauaauaaauaucggaacaaaaccuggua
31 AW049031 uuuuuuuuuuuuuuuugcugauaagaauucuuuuuuuguuauucgauaaaauaca
uucauacagaaauauaacaaucucgcaaaaaacaauucaaauaaaaucuuguaaaacaaa
auuuuacaaaaaucuuacaaagauucuuuagauaacagggugcuucaaaaaaaaagaaau
aaagaaauuucacuauuagaaauuuuuuuuuuuaauuucaagcauaaguuccugcuugau
ugaggcucaguugucaccugaccagaauggacugcuuaguauuaaaguuacagcaucgac
acggacggcacccagccccagccaguccagcaacgucgcuguguuucauaagugagacgc
gccagcacaaguuuccucucucuucuguuaccuucuuacuuaauggaauugcuauggau
aagcacacagcagggccaaaaaaggaguuuuccaaaauccaccaaaucaagu
32 M93275 uaguggugaucuggaccgugcggacuugcucgucccucagcucuccuguuaggcgucuc
u
ucuccaggaggaaaaaauggcagcagcaguaguggauccgcaacagagcguggugaug
agaguggccaaccugcccuuggugagcucuaccuacgaccuguguccuccgcuuauguc
aguacaaaggaucaguacccguauuugagauccgugugugagauggccgggaagggcgug
aagaccgugaccucugcggccaugacaagugcccugcccaucauccagaagcuggagcca
caaauugcgguugccaauaccuaugccugcaaggggcuagacaggauggaggaaagacug
ccuauucugaaccagccaacguccgagauuguugccagugccagaggugccguaacuggg
gcgaaggauguggugacgacuaccauggcuggagccaaggauucuguagccagcacaguc
ucaggggugguggauaagaccaaaggagcagugacuggcagcguggaaaggaccaagucu
guggucaauggcagcaucaauacaguuuuggggauggugcaguncaugaacaguggagu
a
gauaaugccaucaccaagucggagaugcugguagaccaguacuucccucucacucaggag
gagcuggagauggaagcaaaaaagguggaaggauuugauaugguucagaagccgagcaac
uaugaacggcuggagucccugucuaccaagcucugcucucgggcuuaucaccaggcucuc
agcaggguuaaagaggccaaacaaaagagccaggagaccauuucucagcuccacuccacu
guccaccugaugaauucgccaggaagaauaugcacagugccaaccagaaaauucagggu
gcucaggauaagcucuaugucucguggguggaguggaagagaagcaucggcuacgacgac
accgaugagucccacuguguugagcacaucgagucacguacucuggcuaucgcccgcaac
cugacccagcagcuccagacuacaugccagacuguccuggucaacgcccaaggguacca
cagaacauucaagaucaggccaaacacuugggggugauggcaggcgacaucuacuccgua
uuccgcaaugcugccuccuuuaaggaaguguccgauggcguccucacaucuagcaagggg
cagcugcagaaaaugaaggaauccuuagaugaaguuauggaunacuuuguuaacaacacg
ccucucaucuggcugguaggucccuuuuauccucagucuaccgaggugaacaaggccagc
cugaagguccagcagucugaggucaaagcucaguaaaccccuccuugucaccagagcaug
auguugcuggccagaugaccccuuuugcuguauugaaauuaacuugguagauggcuuua
g
cuuagaaaagcagcuucuuagaaccaagggccucauuauggucacucacagcucaguuau
ggucuugccccagcuggcccuggcacaggaguucucuuaccuggcuggugaguggccug
u
guuagucuugugaggaccuggaggaaccuaaaagcucagaugcacuuacagucuugucug
uggccuuuguauuguuauuggcuguaaucgucugucuggaccgaauauagauucacgug
a
33 AB000713 ggcacgagggagcugcaguguucgcgcuugguagcuggugcaucggacucagcuggcuu
u
gugucccugaggcucaccgaaaaacacuuucucagcccucugacuccagagagagagaga
gagagguacuuuuuguggucaccgacuuugaccccugcagaggcugagcgauggcgucu
a
ugggacuacagguccugggaaucuccuuggcaguccugggcuggcuggggaucauccug
a
guugugcgcuccccauguggcgggugaccgccuucaucggcagcaacaucgucacggcac
agaccagcugggagggccucuggaugaacugcguggugcagagcacaggucagaugcagu
gcaagauguacgacucgaugcucgcccugccgcaggaccugcaggccgcccgagcccuua
uggucaucagcaucaucgugggugcucuggggaugcuucucucagugguagggggcaag
u
gcaccaacugcauggaggacgagaccgucaaggccaagaucaugaucaccgccggagccg
uguucaucguggcaagcaugcugauuauggugcccguguccuggaccgcucacaacguca
uccgcgacuucuacaacccuaugguggcuuccgggcagaagagggaaaugggggccucgc
uuuacgucggcugggcggccuccgggcugcugcuccugggaggaggccuccucugcugc
a
guugcccaccucguagcaacgacaagcccuacucggccaaguacuccgccgcccgcucug
uccccgccagcaacuauguguaaggugggccacucuguccacauugccuuuguuauuuuu
ucggauugagcucauaacagccuguggccccucacauucuccaggaccugcccugcua
ugggccacuaacugcuugcuggggacaggcaaacccggacugugcaaaguuacuagcccg
ugcucuugggcugcuccacauggcuccuuacggccggcaagaauggauguaaaaauauc
uugcugcuuacauccaaauugcgguggauaugggcugaaggcagaagcagcugggaagg
g
caguagaggcgcaagcuggguccugcuggccgggguagcucagcugugacuuuggacuc
gaguggauguccucauguuagcaaacguccacuguccuuucucuaucccccucacucagc
cuacacguuacuccagcgcuacucuugccauuacgccccguguuuccgagcacagcuggu
ccuaccccaagucauggugugcugagugacugaugaggggccauugagagccggugggc
u
cugccauggaacccuuccguugauuagcaaugacugugcuugacccacccaccuacccua
cuaaugaauuucuguagaguggauggacggguuugagggaagaaggguggagguggauu
aaacugguuuggggagggcuggggaccuagaagcagcccaguguguccccaccccuuuuc
c
gcacugucuugcuaauguucugaucacugugcgcccccucccucuucagauggacccugg
gccucuugaguuggccccucugaguucccucccuuugcccauuucaaggacaccggccag
ucugcggaaggaagguacggggggggggggggggggugauggcauuguaccagggaguc
uccuggacuccccugccuucucugugguuucuuguuuuguaauuaaggucuguucacag
cuguaauuauuauuauuuucuacaauaaauggcaccugcauacag
34 U20735 See above (same Accession Number).
35 U83148 augcagcugagaaaaaugcagaccaucaaaaaggagcccgcaccccuagauccuaccagc
agcucagacaagaugcugcugcugaacucugccuuagcugagguggccgaggaccuagcc
ucaggugaagauuugcuugaacgaagggagcauggggaaaaacaaauccucggcgugu
cggagaaaacgggaaucauuccggacgagaagaaagacgccauguauugggagaaacgg
cggaaaaacaacgaagcugccaaaagaucucgggagaagcgccgccucaaugaccugguu
uuggagaacaagcugauugcccugggagaagaaaaugccacuaaaagcugagcugcuc
ucccugaaauuaaaguuugguuuaauuagcuccacggcguaugcccaagaaauccagaaa
cucaguaauuccacagcugucuacuuucaggacuaccagacauccaaggcugccgugagc
ucuuuuguggacgagcaugagccugcgaugguagccggaaguugcaucucagucaucaag
cacucuccccagagcucgcucuccgaugugucagagguguccucgguggagcacacucag
gaaagccccgcacagggaggcugccggagcccugagaacaaguucccugugaucaagcag
gagcccguggaguuggagagcuuugccagggaggccagggaggagcggggcacguauuc
c
accuccaucuaccagagcuacaugggaagcucuuucuccacuuacucccacuccccaccc
cucuugcagguccauggguccacuagcaacuccccaagaaccucagaggccgaugagggu
guaugggcaagucuucugauggggaagacgaacaacaggucccuuagggccccauccau
ucuccaguggagcugcaacggguucacgccacgguggugaaggccggaagugaacccu
ucugccuuaccgcacaagcuucggaaaaagccaaggccaugcaggucaaaguggaggcu
uuggacagcgaguuugaaggcaugcagaaacucucuucacccgccgaugcgaucgccaaa
agacauuuugaccuggagaaacauggaaccucggguauggcccauuccucccucccuccu
uucucagugcaggugacgaacauucaagauuggucccucaaaucggaacacuggcaucac
aaagaacugagcagcaaaacucagaguagcuucaaaacaggugugguggaagucaaagac
gguggcuauaagguuuccgaagcugagaauuuguauuugaagcagggaauagcaaacuua
ucugcagagguggucucgcucaagagauucauagccacacaaccgaucucggcuucggac
uccagguaa
36 L10244 gcucccgggaaacgaaugaggaaccaccuccuccugcuguucaaguacaggggccuggug
cgcaaagggaagaaaagcaaaagacgaaaauggcuaaauuuaagauccguccagccacug
ccucugacugcagugacauccugcgacugaucaaggaacuggcuaaauaugaauacaugg
aagaucaagucauuuuaacugagaaagaucuccaagaggauggcuuuggagaacaccccu
ucuaccacugccugguugcagaagugccuauagagcacuggaccccugaaggacauagca
uuguugggucgccauguacuauuuuaccuaugacccauggauuggcaaguugcuguau
c
uugaagacuucuucgugaugaguganuacagaggcuuugguauaggaucagaaauuuug
a
agaaucuaagccagguugccaugaagugucgcugcagcaguaugcacucuugguagcag
aauggaaugaaccaucuaucaacuucuacaaaagaagaggugcuucggaucuguccagug
aagagggauggaggcucuucaagauugacaaagaguacuugcuaaaaauggcagcagagg
agugaggcgugccgguguagacaaugacaaccuccauugugcuuuagaauaauucucagc
uucccuugcuuucuaucuuguguguagugaaauaauagagcgagcacccauuccaaagcu
uuauuaccagugacguuguugcauguuugaaauucggucuguuuaaaguggcagucaug
uaugugguuuggaggcagauuucuugaacaucuuuugaugaugaacaaggugguaugau
cuuacuauauaagaaaaacaaaacuucauucuugugagucauuuaaauguguacaaugna
ca
cacugguacuuagaguuucuguuugauucuuuuuuuaaauaaacucgcucuuugau
uu
37 U88328 cgcuggcuccgugcgccauggucacccacagcaaguuucccgccgccgggaugagccgcc
cccuggacaccagccugcgccucaagaccuucagcuccaaaagcgaguaccagcuggugg
ugaacgccgugcgcaagcugcaggagagcggauucuacuggagcgccgugaccggcggcg
aggcgaaccugcugcucagcgccgagcccgcgggcaccuuucuuauccgcgacagcucgg
accagcgccacnucuucacguugagcgucaagacccagucggggaccaagaaccuacgca
uccagugugaggggggcagcuuuucgcugcagagugacccccgaagcacgcagccaguuc
cccgcuucgacuguguacucaagcuggugcaccacuacaugccgccuccagggacccccu
ccuuuucuuugccacccacggaacccucguccgaaguuccggagcagccaccugcccagg
cacuccccgggaguacccccaagagagcuuacuacaucuauucugggggcgagaagauuc
cgcugguacugagccgaccucucuccuccaacguggccacccuccagcaucuuugucgga
agacngucaacggccaccuggacuccuaugagaaagugacccagcugccuggacccauuc
gggaguuccuggaucaguaugaugcuccacuuuaaggagcaaaagggucagaggggggcc
ugggucggucggucgccucuccuccgaggcacauggcacaagcacaaaaauccagcccca
acggucgguagcucccagugagccaggggcagauuggcuucuuccucaggcccuccacuc
ccgcagaguagagcuggcaggaccuggaauucgucugaggggagggggagcugccaccug
cuuuccccccucccccagcuccagcuucuuucaaguggagccagccggccuggccuggug
ggacaauaccuuugacaagcggacucuccccuccccuuccuccacacccccucugcuucc
caagggagguggggacaccuccaaguguugaacuuagaacugcaaggggaaucuucaaac
uuucccgcggaacuuguuugcgcuuugauuugguuugaucaagagcaggcaccugggg
g
aaggauggaagagaaaagggugugugaaggguuuuuaugcuggccaaagaaauaaccacu
cccacugcccaaccuaggugaggagugguggcuccuggcucuggggagaguggcaaggg
g
ugaccugaagagagcuauacuggugccaggcuccucuccauggggcagcuaaugaaaccu
cgcagaucccuugcaccccagaacccuccccguugugaagaggcaguagcauuuagaagg
gagacagaugaggcuggugagcuggccgccuuuuccaacaccgaagggaggcagaucaac
agaugagccaucuuggagcccagguuuccccuggagcagauggaggguucugcuuuguc
u
cuccuauguggggcuaggagacucgccunaaaugcccucugucccagggauggggauug
g
cacacaaggagccaaacacagccaauaggcagagaguugagggauucacccagguggcua
caggccaggggaaguggcugcaggggagagacccagucacuccaggagacuccugaguua
acacugggaagacauuggccaguccuagucaucucucggucaguagguccgagagcuucc
aggcccugcacagcccuccuuucucaccuggggggaggcaggaggugauggagaagccuu
cccaugccgcucacaggggccucacgggaaugcagcagccaugcaauuaccuggaacugg
uccuguguuggggagaaacaaguuuucugaagucagguauggggcuggguggggcagcu
guguguugggguggcuuuuuucucucuguuuugaauaaugugggacaauugccucaauc
acuuuuauaaaaauccaccuccagcccgccccucuccccacucaggccuucgaggcugucu
gaagaugcuugaaaaacucaaccaaaucccaguucaacucagacuuugcacauauauuuau
auuuanacucagaaaagaaacauuucaguaauuuauaauaaaagagcacuauuuuuaau
gaaaaaaaaaaaaaaaaaaaaaaaaaa
38 X82786 Sequence below.
aaggaaccaguacagaaacaagacccaaguguaaguuaacuggcaggaggaaccaaccaaggacaguuaagga
gaaaacccaacccuuagaagaacucaccaguuuccaagaggaaacugccaaaagaauaucuuccaaaucuccacaacc
ggaagagaaggaaaccuuagcaggggaaagaggcagcucagaauacaacuaaucaacgaugguguaaaagaagagc
ccacagcacagagaaagcaaccauccagggaaaccaggaacacacucaaagagccuguaggugacaguauaaauguu
gaagagguuaugaagucuacaaagcagaaaauugauccaguagcaugugugccugucagcaagaggccacggaggg
uacccaaggaaaaggcacaggcccuagaauuggcuggucucaaaggaccaauccaaacccuaggccacacugaugaa
ucagcaagugauaaaggacccacacagaugcccuguaauucucuacaaccagagcaaguugacagcccaaagcuc
accaaggcgacccaggacaagacgugggaaaguagaggcagaugaagagccuucagcaguaagaaagacaguaucaa
caucaaggcaaacuaugcgaucccgcaaggucccugaaauugguaacaaugguacccaaguuucaaaggccuccaua
aagcagacauuagauacaguagccaaaguaacuggcagcaggaggcagcuaaggacacauaaaggaugggguucaac
ccucuugaaguguuaggugacuccaaagaaauaacccaaauaucagaucacgagaaacuagcacaugacacca
guauccuuaagagcacucaacagcaaaagccagacucaguaaccucugagaacaugcagaagagugcugagggcc
ucuaaagagguccccaaggaaguguugguggacaccagagaccaugcaacauuacaaagcaaaagcaacccuuugcu
guccccgaagaggaagucugcaagagauggaagcauugugagaaccagggcuuugcgcucuuuagcaccaaagcag
gaagcaacagaugagaagccuguaccugagaaaaaaagggcugcuuccagcaagagguauguaucaccugagccug
ugaagaugaaacaccugaaaaucgugucaaacaaacuugaaucuguggaccagacaaugacaguuuggau
gaagaaauggaagccaaaagagaaaauccugucacuccagaucagaacucuagguaccgaaagaaaaccaauguaaaa
cagccaaggcccaaguugaugcaucugcagagaaugucgggauaaagaaaaacgagaagacuaugaagacugccuc
ccaggagacagagcugcagaauccagaugauggagccaagaaaucuacaucucggggccaagucagugggaaaagaa
caugcugaggucuagaggaacgacugagaugccccagccuugugaagcagaagagaaaacaagcaaaccagcugca
gaaaucuugauaaagccucaggaagagaaaggagucucuggagagucugauguuagguguuugagguccagaaa
cuagagucgcuuuggacagugaaccuaagccaaggguaacucguggaaccaagaaagaugcaaaaacucugaaggag
gaugaagacauuguaugcaccaagaaguuaagaacaagaaguuaagaacaagaaguuaccagaaaagugaaacuaug
uagcaaagacauuuaagaaggaaaaguaaauuugacuuagugauaaguuccagugugguuuucaccuccaguguaa
agaugaacuguuaauacuacugcuacugccugaguuuaaggaaggaagcuuugagcuuuccuggucauacucucuu
cagacgccaauggaggucaugaggaagaucaccagggaucucagcgcaauuacaguaggggugagcaggcagaa
auccccucuccuauccaauaaauucucuaauucccccaaaa
39 AW122523 uuuuuuuuuuuuuuuaanucaaaaguuaugaugacuuuauuuuaaaucuuaauacac
c
aaaaauauuuuucaauguugugagauaagcacuugaaaauaagaauuccaucacugcugu
gaucgcugugaggcuugauagugaauuucccucugaauauggguuuagggccuagg
a
agcagaaugccagucauuuuccaaguagcagugagcuaagcccagcccggucaugcucag
acccacacuuaacugaaauauucacacuaggaggcggcaccaccaggcaacaccuugauc
aaccaggagaacaaaagucugaagugccaccaagcauuggggaaaugauauuguuuagau
gcuagugagucagguucuuucaaaugnguccuaacuggguugcaaacauaguugcauccu
uau
40 AI642048
aauacaacauauacaacauuacaagaaggcgacacagaccaguugggggcgacuuuu
aagcacaugccacugaacaccuggcucuuacaugggaggacacacugggcucacuuacua
ggucuauggugguucaaucaaaagcacaauaaauaaaacgugguccuuucauuagguucu
ggaaaaucaccucccccccccccaaauaaaaucccacauacaugaaccuuaagagacauu
uucuuugaauuucagugaucuguuuccccggauuucacaaagacaacagccgaaucaccc
caguaaaaugccugggucuaggcgcugugugguguggugcuaaguauacccuuucucau
u
uuuuuucuuuuucu
41 L07264 cggccgccagaccuucaagggcuggaguggacgcgcggaccgacucugaac
aaccgcggccgcaagguucccagacaggaucucacccagaggcaggcagcggacagugcc
uuaguggaaccucgcguccuccaccgccuggccccggugcaggcguccaguggccgccg
cauccaaagugaucgcugccuccccgucuccgccagcucgggaccaugaagcugcugccg
ucggugaugcugaagcucuuucuggccgcaguguuguccgcguuggugaccggugagag
u
cuggagcggcuucggagaggucuggcggcagcauccagcaacccugacccucccacugga
uccacaaaccagcugcuacccacgggaggugaucgugcucaggggguccaggacuuggaa
gggacagaucugaaccuuuucaaaguugcuuucuccuccaagccacaaggccuggccacc
ccaagcaaagaaaggaaugggaaaaagaagaagaaaggaaagggguuagggaagaagaga
gacccaugccucaggaaauacaaggacuacugcauccacggggagugcagauaccugcag
gaguuccguacucccucuugcaaaugccucccugguuaccacggacacaggugucauggg
cugacucuaccaguggagaauccccuauacacauaugaccacacuacagucuuggcugug
guggcuguaguacugucguccgucugucuucuugucaucgugggacuucucauguuuag
guaccacaggagaggagguuaugacuuggaaagugaagagaaagugaaguugggcgugg
cuagcucccacugaggaggaccugagcuauaggaaccuucagaggcuacuucugagacag
ug
guucguuacacguucuacauagaggagaaauauucaccagcagccaugaaaacgucuuc
auucauuuccaguugcuacccugacugggccuccuguaau
42 M15668 ucgaccucacggucuugccaaaaugucgcuuuccaacaagcugacuuggacaagcugga
cgugaaggggaagcgggucgugaugaggguggacuucaacguuccuaugaagaacaacca
gguaacaaacaaccaaaggaucaaggcugcuguuccaagcaucaaauucugcuuggacaa
uggagccaacuccguuguccuuaugagccaccugggccggccugaugguguucccaugcc
ugacaaguacucuuagagccaguugcgcugaacucaaaucucugcugggcaaggaugu
ucuguucuugaaggauugugugggcccagaagucgagaaugccugugccaacccagcggc
ugggacugucauccugcuggaaaaccuccgcuuucauguagaggaagaagggaagggaaa
agaugcuucugggaacaagguuaaagcugagccggccaaaauugaugcuuuccgagccuc
acuguccaaacuaggagaugucuaugucaaagaugcuuuugggacugcacaccgagccca
uagcuccauggugggugugaaucugccacagaaggcugguggauuuuugaugaagaagg
a
gcugaacuacuuugccaaggcuuuggagaguccugagcgacccuuccuggcuaucuuggg
aggcgcuaaaguugcagacaagauccagcugaucaauaauaugcuagacaaagucaauga
gaugaucauuggugguggaauggccuuuaccuuccuuaagguccucaacaacauggagau
uggcacaucucuguaugaugaagaaggagccaagauugucaaagaucucauguccaaagc
ugagaaauauggugugaagauuaccuugccuguugacuuugucacugcugacaauuuuga
ugagaaugccaagacuggccaagcuacuguggccucugguauaccugcuggcuggauggg
cuuggacugugguacugagagcagcaagaaauaugccgaggcugugggucgagcuaagca
gauuguuuggaaugguccugugggguauuugaaugggaagccuuugccaggggaacca
u
gucacucauggaugagguggugaaagccacuucuagggguugcaucacuaucauaggug
g
uggagacacugccacuugcugugccaaauggaacacagaggauaaagucagccaugugag
cacugggggcggugccagucuagagcuccuggaagguaaaguccuuccugggguggaug
c
ucucagcaauguuuaguauuugguccugccuuugguuccugugcuccuaagcuaacc
u
gcuguuuuccacaucuccauuugguguuagcgcaagauucagcuaguggcugagaugug
u
cacagaccuuaacagugcaagcaucucagcucgucuuacugcaucagaugcugguucuuc
aagaucccauuuaaauuccuuagugacuaaaaccauugugcauuguagagggcgucuauu
uauauucugccugagaaaggaagugagcuguaaaggcugagcucucucucugacguaugu
agccucugguuagcuucgucacucacuguucuugacucagcauggcaaucugaugaaauu
cccagcuguaagucugcagaaauuuccgaauuc
43 AI1047508 uuuuuuuuuuuuuuuucauguuuaauaguuuauuucuuauuuuguugcuuauaucuuc
aauaaaucauunugcagguuuuguuacagauuuuugauaagccaacucaaguacugauuu
uucauccucucugaaaguuuuaaaccaggaaaggaaaacguuccauggaauccaucuucca
cauggugaugagucacaugaacuccaacauucugaagccgcuugacauacaugaguccau
c
aucucuuaggacaucauacuggcuugugaugauauaggucuuagguaaaugaugcaauau
auugucauuggccaacugagggcaugccuucacaucuaugaacccuggauacuuuugagc
cagcucagaacuaccaggagugggauuuuuguaaacgggacuuuucuuguaucucucagg
gagcaaggaacuccaauucacaaacuguaacaaguggcuagauuccauggguacauguug
guuga
44 AJ001418 Sequence below.
gagcacccgggacccugggaccacaacgcacuugcucccucucgaccgcgcuccugacccgcagcccucgccaacccuacgg
auccuaaccaccgccagccuaggugggcgucaggaugaaggcagcccgcuucgugaugcgcagcgccagcucgcuga
cgccagccugguccccagggaggucgagcuguucucccgcuacagcccguccccgcuguccaugaagcagcugcuggacuu
ugguucagaaaaugccugugaaaacguccuuugcuuuucugcggcaagagcugcccgucgccuggccaauauccugaa
ggagauugacauccugccugaccgcuuagugaacacuccuucggugcagcuggugaagagcugguauauccagagccuga
uggauuugguggagnuccaugagaagagcccagaagaccagaaagcccugucagaguuuguagacacgcuggacaaaguuc
gaaacagacaucauaauguggucccuacaauggcucaaggcauccuggacuauaaagacaccugcacaguggaccccguuac
caaucaaaaucuucaguauuuuuuagaccgguuuuacaugaaccgcauuucuacucggaugcucaugaaucagcacauccu
cauauucagugacucaaagacgggaaacccaagccacauuggaaguaucgacccaaacugugaugugguagcaguagucca
agaugccuuugagugugcaaagaugcucugcgaccaguauuaucuaacaucgccagaauuaaaccucacacaagucaaugg
aaaauuuccaggccaaccaauccacauuguguacguuccuucacaccuucaccacaugcucucgaacucuucaagaaugcc
augagggccacggucgagcaucaagaaaaccguccuuccuugaccccaguagaggccacugucgucuugggaaaagaagac
cuuacaaucaagauuucugaccgaggaggcgguguuccucugaggauuacugaccgccucuuuaguuacacguacuccacu
gcuccaacaccugugauggacaauucccggaaugccccuuuggcugguuuugguuauggcuugccaauuucucgucucua
cgccaaguauuuucaaggagaucugaaucucuuacucuaugucagguuaugggacagacgcuaucaucuacuuaaaggcuuu
auaucugagucuguagaaaagcucccagucauuaacaagucagccuucaaacauuaucagaugagcuccgaagcugauga
cugguguaucccaagcagggaaccgaagaaccuggcgaaggagaagcuggcagugugaagcggaugacgccugacauuuua
cgggaucaaagugggucuguggcauugcugcuucgugaauguguguggacucuaguuuccgcaaaacaacgcaacacaaaa
ccaagcaagcaaaacacaaacacgaguacaaaccuugaccugaugagggacagagcuugguuggaugacccgggagaaguca
gggcagggcuccaggggauaacagguguccugcuucuccuuuggcaaugcaauuugacuccugacuguuccaaauacugaa
aagaagucugccucugaguuacagcucuuucucaacaaguacagaguuugaggcuugcaguugcaacagcuggauguuug
gugguucuugcugccagccaaauaaauugguguuuagugaacauuuucaguguuuccccgccaugcaaagcuuggcgccu
ugggagaaauguguguaaauguacauuguauagguauuagugugcucuagaacccaccagcaggccaggaccag
uuaucgagcuuguggcugagcauugcagccuaugugcaaacccagaggaaaaguaucucugucaagacagcuccaguauca
ugcagcuuuuuauguuugcacucaaaaagccagugccuucuggcuggugccgaggcuugggugaaauguuaaauaugcac
ugaccucagaaagucgaguucaaaagggagauaaaauugccaaagugauccaaggauugugcauguugggaaacccauaug
agagaaaggauucucauacuuagaacuuuccuaugaagaaauggugguaaacuuucucuaccuagaaguaguggaaauuuc
aaggucaucuuaaaaaagaugugcguuguauauuuuaacuacauucucuacacucuaacauuaacauaucuauucaaauuu
gucuaguugccaauugucuucagagugugaaaauuuaaauccuucuugaaguaucuuucgugagaguaguauggaaguaa
aacguucucauaucaggaggaugucauuugugaagcaugggacggcggcaagaagggacccagaaga
ugaaggguaaggaucagcgggaggccauccauguaggagagagaauuaaaucgaggagcgagggaagcaauggagagagg
gaagcaagaaaggaaccagaaggcuggcaucauccuauuucccacaggcuaacccaagggaugcucugugccuuuccuggg
gagggaagggggugaacugguagauuugaaagcaguauggcuucuucugugggucucccucuuacuagacaaggugaaau
gauaauucgugucaaauuaaugugaaauuuuuuuccugcauuguaauauuaugaggccugagucgcaguugaguuugaaa
uuuguauuuaauucacagugaccuagagcuaaggugcucccgguuguggcaauaggagccacaaguauuuucuuucuuu
cuuucguucuuucuuucuuucuuucuuucuggcggcaacgcggccgcacacgagaccaaccaaacggca
uccuuccuuccuuccuucuuccuuuccuuucuuuucucuucucuucuuucuuuuuucuguuucuuuuucuuuuuggg
cauuguagauguuguccuuaaaagaucagggcagugacuuucacagcaggacuuugacucccacauugguugaucacacaa
aacugucagcauuuggguaaucugauguauaguuguuuuguugcugauguuuccauugaaauucagcucugaguuugu
gcacaugaauacuuacuuguggguaccaaaggucuaaggcauuugacuuaacccaaauauccugaacugugcguaaag
uaauagagaaaagcuuuagggucucaauagugucaccuguguaaaucaaaucaaaauagccuucccuauuauuuaugaacc
caugggagacuuuaaacucuuguagaaagaugcuaaaugcccaggcccacuuaacuuauuaaugugugaauuacauuuaug
uuuuuaguuuauaugcaaagaauugugauaauuuuauaauaaauauuuuuauuauuauagu
45 AI838080 uuuucuuuuuuuuuuuucuucucuuuuuucugccaccaacagcacugugcaguuuauua
accauucauguacaguagccaucuggggagauugggacagaauugggaucgcaaagugga
uagauauucagcaucuaauggguuggcagaagccgccauauacucuucacaaauaucuuc
c
acagucaauacagaacuagccauaucccagcacaccgauuugugc
46 AF072127 agccaggagccucgccccgcagcugcncagagagcaaggguauaggcacuaacuuguuug
cagauaccccaucaccuucgggagcucaggugcgcaccuugcaaacuccacuuucugcau
cugccacugagcccgcgggagccucggaaagagccauggccaacgcggggcugcagcugc
uggguuucauccuggcuucucugggauggaucggcuccaucgucagcacugcccugcccc
aguggaagauuuacuccuaugcuggggacaacaucgugaccgcucaggccaucnacgagg
gacuguggauguccugcguuucgcaaagcaccgggcagauacagugcaaagucuucgacu
ccuugcugaaucugaacaguacuuugcaggcaacccgagccuugaugguaauuggcaucc
ugcuggggcugaucgcaaucuuuguguccaccauuggcaugaagugcaugaggugccug
g
aagaugaugaggugcagaagauguggauggcugucauugggggcauaauauuuuuaauu
u
caggucuggcgacauuaguggccacagcaugguauggaaacagaauuguucaagaauucu
augaccccuugacccccaucaaugccagguaugaagggggggccaggcccucuuuacuggcu
gggccgcugccucccucugccuucugggagguguccaacuuuccugcuccuguccccgga
aaacaaccucuuacccaacaccacggccuuaucccaagccaacaccuucuagugggaaag
acuaugugugacagaggcaaaggagagaucuuccuggagcaaauacaaaauggacauug
aaccuaggauugacauuaacgccuuagacuguugaugaugguuaucggaacugugguaga
acagaaggaagcauauuuuuauacauccccauggcuauncaugccuuggcug
47 X80417 Sequence below.
cggcacgagcggccacugaccgagaagugcccccgccuggagucagccugggggcaggccaggguccaccagaccc
cgggaugaccgcagccagucgggccaaccccuacagcaucguaucaucagaggaggacgggcugcaccugguuacca
ugucaggcgccaacgguuuuggcaauggcaaggugcauacacggcgccggugccgcaaccgcuucgucaagaagaa
cggucagugcaacauugaauucgccaacauggacgagaagucacaacgcuaccuggcugacauguuuaccacgugu
guggacauccgcuggcgcuacaugcugcucaucuucucucuggccuuucuugccuccugguuguuguuuggcauc
aucuucugggucauugcugucgcccacggggaccuggagccagccgagggccguggccguacacccugugugcugc
agguccacggcuucauggcagccuuucucuucuccauugagacacagaccaccauuggcuacgggcuacgcugugu
gacugaagagugcccgguggcugucuucauggugguggcgcaguccauugugggcugcaucauugacuccuucau
gaauggugccaucauggccaagauggcacggcccaagaagcgcgcacagacucugcuuuucagccauaaugccgug
guggcucugcgugacggcaagcucugccucauguggcgcgugggcaaccugcguaagagucacaucguggaggccc
augugcgggcccagcucaucaagcccagggucacagaggagggugaguacaucccacuggaccagauugacaucga
ugucggcuuugacaagggccugaccguaucuccugguaucacccaucaccaucuugcacgagauuguugaggcc
agcccacuguuuggcauuagccgucaggaccuugagacagacgacuuugagauuguggucanccuggagggcaug
gugaggccacagccaugaccacacggcucgcaguuccuaccuggcuuucgagaucuguggggccaccgcuuug
agccagugcucuucgaagagaagaaccaguacaagauugacuauucacacuuccacaagaccuacgaggugccaucu
acaccccgcugcagcgccaaggaccugguggagaacaaguuccuccugcccagcgccaacucuuucugcuaugagaa
cgagcuggccuuccugaucagagaugaggaggacgaggugucuaccgaccgggauguccgcaccccucagcccgag
caugacuuugacagacugcaggccagcagcgcugcccuugugcggcccuacagacgggagucggagauuugaaugc
ccuuggcuuagaugcagcaccacccugaccacaauaggucccaugucccuugggggccugcguuugagcagagcag
gccgaaagccucgggucacagacucaguagcaucuuagucuuuuucauguuuuuucgcaguagcuugggaaaguu
ggcgggagcguggauggcccaaaugacuggcucacggccucggaggcugauguauacccaugggcaaggaggugac
uucuugggguagggnugcucaggaguuagggacucugcuggaggccuuaggugcaggucccauccccggugggag
gaggcuguguauguacacuucauugguuuuuaacuugggcaagacuguuuacaaaccaaaacaaacaaacaaacaau
c
caaaaaaaaaaaaaaaaaaaaaaaaaaaa
48 AI847051 uuuuuuuuuuuuuuguuccuuuuuuggaauucccaaagcugguuuuaauuucaaaaaau
uaugaggucucuucccacacuggggauaaugggaugggauagcccaaacuauuaucccag
u
ucaaccccagccugguccaaacaccau
49 U09504 uccucguccucgucuguuccaucuucuccaaauagcucuaacugugaugccaacggcaau
cccaagaacgcugauaucucuagcaucgaugguguucugaagagugaccgcacagauugu
ccugugaaaacaggcaaaaccagugcuccuggcaugacuaagagucacaguggaaugaca
aaauuuaguggcaugguucuacuguguaaagucuguggggauguggcaucaggauucca
c
uauggaguucaugcuugugaaggcuguauggguuucuuucggaggagcauucagcaaaa
c
auccuauaagaagugccugaagaaugagaacuguuccaucaugaggaugaacaggaac
cggugccagcagugccgcuuuaagaagugucugucuguggggaugucacgagaugcugu
u
cgauuuggccgaauuccuaagcgugaaaaacagagaaugcuaauugaaaugcaaagugca
augaagaccaugaugaacacccaguucaguggccaccugcagaaugacaccuuagcagaa
cagcaugaucagucagcacuaccagcucaggaacagcugcggcccaagucccagcuggag
caagaaaacaucaaaaacacuccuucugauuuugcaaaggaggaagugauugguauggug
accagagcccacaaggauaccuuucuguauaaucaggaacaucgagaaaacucaucugag
agcauguaccucagagaggagaacggauucccaggaacauggagcaauauaauuuaaau
caagaccaucguggcagugggauucacaaccacuuccccuguagugagaggcagcaacau
cucaguggacaguacaaagggaggaacauaaugcauuacccaaacggccaugccguuugu
auugcaaauggacacuguaugaacuucuccagugcuuauacucaaagagucugugauaga
auuccagaagguggauguucucagacugagaacagaaauaguuaccugugcaacacugga
gggaggaugcaucugguguguccuaugagcaagucuccauauguggacccucagaagucu
ggacaugaaaucugggaagaauuuucaaugaguuuuaccccagcaguaaaagagguggug
gaauuugcaaagaggauuccuggcuuccgagaucugucucagcaugaucaggucaaucug
uuaaaagcugggacuuuugagguuuuaaugguacgauuugcuucauuuuuugaugcaaa
g
gaacggaccgucaccuuucuaagugguaagaaguacaguguggaugaccugcacucaaug
ggagcaggggaucugcucagcucuauguuugaguucagugagaagcugaaugcccuccag
cucagugaugaggaaaugagcuuguucacagcaguuguucugguaucugcagaucgauc
u
ggaauugaaaaugucaacucaguggaggcuuugcaggaaacacucauccgugcacuaagg
accuuaauaaugaaaaaccauccaaaugaggccuccauuuuuacaaaauuacuucuaaag
uugccagaucuucgaucuuuaaacaacaugcacucugaggaacucuuggccuuuaaaguu
cauccuuaa
50 U22033 auggcguuacuggaucugugcggugccgcucgggggcagcggcccgagugggcugcccu
g
gaugcgggaagcgggggucgcucggacccgggacacuacaguuucuccgcgcaagcuccg
gagcucgcacuuccccggggaaugcagcccaccgcauuccugagguccuuuggugguugac
caggaaaggaauguucaaauugagauggcccacggcacaaccacacucgccuucaaguuc
cagcauggcgucaucguggcuguggacuccagggccacugcagggaguuacauuagcucc
uuaaggaugaacaaagugaucgagauuaacccuuaccugcuuggcaccaugucugguugu
gcagccgacugccaguacugggagaggcuguuggccaaggagugcagguuguauuaucu
u
cggaauggggaacgcaucuccgugucugcagcauccaagcugcuuuccaacaugaugcug
caguaccgggggaugggccucuccaugggcagcaugaucuguggcugggacaagaaggga
ccaggacuuuacuacguagaugacaaugggacucggcucucgggacagauguuuuccacu
ggcagcgggaacaccuaugccuacggggugauggacagugguuaccggcaggaccucagu
ccugaagaggccuacgaccuuggccgcagagguauugcuuaugcuacccacagagacaac
uauucuggaggagucgucaacauguaccacaugaaggaagacgguugggugaaaguggag
aguuccgaugucagugaccugcuguacaaguaccgagaggccgcucuguga
51 AF033034 Sequence below.
auuccaggaguuccagcugcuggagaggacuguguagaagguaaccuaccccaucucucuuacuucgucucuagauggga
gcagacaaguacauauagccugcuuggagcgaggacuuugaaaggcugagacuugcguccacucugagggcaacuagucca
gacucugacaggucagcauuuccugacugggugcacugaaugccaagcaccagaggucugucaccuuccgacauuggacca
agagagucccagagacccucaaagacacaggaacagagguguccuuugggugagagaccugugcccugccaagccucucag
ccccuagaaaggcggcagggcugaguagcugagugugugcaacuugggagcagccugauuucagugcuugucaccuguga
gggcaaaggcagcaugcuuaaugccaucaguccuacucuucucacccguggaacagacgcauaacugaccuuuuuucguga
ccacuauuagggugcauuuuaaaaucaagggaccaccagacagccgaacaccgcggacaccaaccccaccggcggac
guguguguguuucugugugugugugcgugcaccauacagguaugugccaugacaugugugcaggucaguagacagcc
uugguugucagucccugccuucuacuuuguucaaggcagggucuauucuuuauuauugacugcuauccagguacaccaag
acaguuggccugugagguuccagggagucuccugucucuggcccccaucuuuauagcaggaguugugagauuucagaaaug
ugcacccacaucuagcuuuauuuggcaucuuggcacccaaacuuggguucucaugcuuuccaagcaaggacuucaccacu
gaaccaucucaccagcuccacuauggcgguuuugaaacugaagggagaacccacaggacacgggccaaacaccagacc
ggaaggcggguauaaccuuuaaggcuggcugguucugagagaggaaagccggcuugugucccauucaggugccaggugca
gcaucaaauguggcuccacccaacggucaguaacuccgcagacagcaccgugguuaucugccucacagagggggcccaggg
accuaguuccuuaaagcccacuuaguuuugagagacgacauggaggggcaagcccagcccuguccagcugcauucacacga
ggccccuccuccgaggacccuaccuguguuuaguggcugaggcuguguggcucugcuugaagcucuggcuaucagg
aaggaccuggcccaccggcuggcaggacaaacuggcccagugaaggcacuguccggucuccugguggaucacaaggaaagg
ggcguggcauguccagauuugaacccuggaugccucuucccaggguaggaagucuaagggucaacaugaauaggugaggg
uggugguggaaagaaucugcaugcaaaaucaggcacucaugucugacaucgucaaacacuauauuuauguagauuuauaug
ggggugaggcuuggggagcacuuguauuuuugugugcaauugcaagagcuuccuccacauugcaguguuaaauaucauau
ggugcuggaccaaccaucucuggaacgagggugaggguuugguacccgugacuaugguucucuguguaguagaaacggc
ucuugggaagagagaggaagugcuuugaaaugcauccucucuuguuucauucugcaucauggccagguuucucugcacaa
agaugcaauagacauucaggaaaauaagcgcauugcaagaugucaaaagucaugaaaaaugaaaagcaaggucacugcagcu
gggguguaguguggcuguugaagcacguuuauguuguucugguuccgggagagggaggaugagugagggagggaaggag
gaauggaggaagagagggagagggagcaagagaggggggagggagggaggggagaagggagagagagagagaagaaagag
agggagggaagaaggaauggaggaagagagagaaagaggggaagaaagagagggagggaaggagggguggaggaagagag
aggugugagggauggagggacagagagggagggaaggagaaauggaggaagagagaaacagagagauggaggaagagaga
uaagucaccaauuauuuucuccccagucgcccccugcccucacaccaaggguucccccacuuuucuuucacucaugcacac
acacuacacccaauguuuagguaacacauguagggcaggcagagccuuugugaaugugcgguaguuuucugccuuacu
ucuaaauaaccaaucacacggaugccacaggguuccuuagacuguccagggcuccggggcucuuagacuguucccaaugu
gggugucacaugcaaacaguaagcaccuucuuguuuguggugcccaggaugcugcagguacuagaaauuccugcacagacc
uuugcuacuucuacacagacuuacccuuuaaaacauuuaauuauauguuauuucagcauaaagaucuauuuugauuauu
uuuaguugcguguaugggugugugccugugugugauuguguaauugucuguaugggaguguaagugccuacagaggcau
cggauccccuggagcugccguuacaaguaagggacugggacucagaccugagugguuuggaugagcagugaaugagcgug
gugagccaucccaccaugcccuauaaacacuuucaagaggacuuugcuggguauggucaaguugucccccugcgacagcca
ccccaacuugccauccucagguuacguacuggaagcagcaaccaccucugcaauuuugcacaagaaccugagagucugaaag
acuuuuguuggcacuggccuguguuccacugggguggacacauuaaucuaaaagcuaagaagcucacuucagcuuugcca
ggcaaccagcacguugagcacaacgguguagccaggaagggugugugggaauuuugaugcuaguuuuucuuuaauuagg
uugagagugaaaucauggucuguaugcauccaacaacuuaauccaaaaaguugguugcacggcuccuggaagguuuaccgg
caaggaaccugucccauuuuguaaguaggugggacuggagaguugccaagaagccccccucccugcccccuuccuuggc
agauucugcuuaaaaugagugugguucacugcagaauagugucaccugucuucagaugucuaaagacauaagaaaggccua
gccagcuaagucagaaaaggggacuuuccggugggaaugcauuuccagucucuaggagaagucuuuauccaaauaaaauu
agcauagugguggagucacugccagggcgcuggugcggaagcacagcccagagccgaggacguggccauccuccuuccucu
gaugcaaaguguucucuauccccaguuaccaugagcaauaucaguagcaucgugaaccgggcccgugaugccuuuaacuca
ggcaagacucgaccgcugcaguuccggguugagcagcuggaggcguugcagcgcaugac
52 AA960603 uuuuuuuuuuccaaaaaauuuuauugggggaaacuacaaaacauuuacaguacaauguuua
cagucacaauuuguagugaacugauuccccaaaauauauuacaacucaaguugacuuaau
cuuuguuacauucaaaaaccuacuucugucaaaguaguccagagugcacacgcggugcucc
aacuguaccuacauacaaacuaaacaacugcucauuuaucugccauccaggaaagccgga
gacauuccugccucuuuacauugaaaaauaauaguacaaguuuuuggacugucauugaac
aaggcauauucauguaccaccaacauuuc
53 U47737 Sequence below.
ggugauccuccaggaccuaagguucgguauuaucuucggggccucuucacccggaggugagucugcugagcccgaccuc
agguguucacucgucacgcgagggccuggccacggcggggaagcacugggagagagcgggaggccuugaccgcagcgugu
aggaucuggggucccggcgcucugcucccgggugcagagugguucccagggaccagagaggaaacccacacgagacac
uaccaucaccccacccccaccccaguccuuccugcacguuucuggagaggcaaaggccccugcugagccuucacuggguacc
ccuaucucgacuccacuugucugcuugggaucuccaaagggggauacacccucguaaacuagagcaggaggcuggggggu
ggggguagggguagggucugaccaguuagauugaggcuggacccuccccagagugaggagcgggaagcucuuugucuuau
ccaggaugggggggcauaucaaugcugaggugggcuggugaagccacacaggcgacacagcgcgccagagccagagacc
cuccgcuggccgcuagccaauagauccuggcuccgcggaugagcccuuugaguuuguggagguguuccucaggucccc
agggcccugccccguugccugcagauguguggacagacaaaacauuggacucguuuuccaaccacuucaccccuuccuucg
cuaguccuccgguggacgaugggaugccucauugacuuguuuguggcugugcaugccagagcuuccuagcagacagcuca
gggcuccaucguuccuaaaucccacuguguaacgaaaaaaaaaaaaacaaaaacaacaacaacaacaacaacaaaaacaaaacc
agaaaugaggacaggcccagcugggcuuggcacugaacuuggccaccuggagcuuuuggcuacccacuacaagaugucagca
agucucaggauagaagaggccuaaggccaguccuggaagauaccaaaacuucaccuccucuauaccccguuccucuaggaga
acuguaagccaccuuugucucugggacgcccucucccacucaacagauggcaccagucaucuuccuccucaagaggccagu
gguauucaaaauaggauaugaaaccaagcaagcugguccucuccucuacccuaugccaaagacuucugcccaaagggccca
gaaaagucccauagccaucuggcuggcuagugugcugacugcuacaggugucaguguccccagcgagcagguaguggagu
ggaggugucuucuuguggaaauggguccugagccucuaccuuguacagaaaggaauuagugaagcccagaggccuccagc
ccgugucucugccacuuugagagaggggguggggguggggcuguauuugguucccagggcucagggaagguuuucgguuc
augcaugcucauuuaucugaccacugucuuuaccccaggacaaccacuuaacuguccacuuccauaucagaguucuugguu
ccccuuacuucgucuauggagccccugaguuugggaagggguauuaacugaaagguaccauuagaugaacuuggagaaa
gauguaggugccacgggagauuucagguaaaagcucuuuaauaauuggcuacaauagcagcaggaggaggccaggaa
uucugagguagagauuugauuagcagcacguggagcaaaggagacuucugacuccuacagguuucagaaaguggggagag
gcucucagaugaauggcuuggacugugagguaaguguuaguguagcacgagacuagcuuaaggcuguacaaauuguccgu
cugauuggugcauugggccagguagacacuagauaagcaauugggccuuaacucgaguugucuuaauggcuacccccagg
gcagcagggagucaauacugcucuuugucuggggccugaaugcugaaaccaucuacaaaggggacauaaggcauauuggg
gagguguagagugggccaggcccagggucugcugguaucuaugccaggauccugaguggugguggcgugccugucuuu
uaaccaacugccucucucacaguaggcuuucuuuggcuugcgaaccuucagcagaugucugccacuuccaacaugagagucu
ucagccugugcuguuggcagcccuucugggcauggagcaaggaauggagcucugagauaacccugcagccugguccucc
uccugaucucucauucuuucuccugaguagaugcccagggcuccuccugagccagcccuccuaggaacgucuggccuuccc
accuccuacucucuagccaacugaccuaguuccccugaugcugugcuggcccagcuacaccuuugucaccucguguugacu
uuagccacuccaguaccaaagucugaagucaguugucauuggcuggcauuuuucccugacccagggcugagcaugcuguu
gcuucuugucaguggguuggggaucaagggccccacuggaaagucaccuuacccuggaaggcuuccccaggcaauaggcag
gugucaccuacagcauugucccuuuugcaguucauucccugaugugcuucucauguaccgaucagaagaacaauauaaacu
gccuguggccaguuucaugccaggagaaagaccauuacuguaucacguuaucugccgcugcgggcuuuggugaguagcug
ccuguuucccuagccagggccagggaccugcggggcuuuccccauuuccugcuacccugucugucuguccccucauccuca
cuuuccaugcagggaaugucaaccuuggcuacacccugaacaagggcugcuccccgaucugccccagugaaaaugucaauc
ucaaucucgguguggcguccgugaacagcuacugcugccaaagcuccuucugcaacuucagcgcagcuggccucggacuuc
gugccaguaucccacuacugggcauuggacuccugcuuagcuuguuggcucugcugcagcugagccccugaccauccccca
uguguucuccauauccccccagcucaggaaaagcccagcuccuuuuuaggucccaggggacccuaggaaccuucagcuccuc
cugggugugucuaguucccccuccacacucucucaacgucagggcuaaguaccaaacucacccauaccugcucuguugaag
ugguacuggcuacccuugcuuccagagccaauccuauaaccucccuuggggaaccagcgaaggggugaagaucuccuugga
gucucaagaguuccagagucagcgccgaaucuuguggacacacugacaaggaugucuaauccaaauagauguauaucugug
ugcucaguguaucccugugugaaugaagccacuuggauucuggggugggcaaagaagaccugaaaagauucuacagcagaa
ggccugugucgccaccaaaaccccucccccugguaucauuguacccaccuuguacucuguucaggaggcugcccauggagg
acugccaccccuccagaugaaggcucccacuacccgaugcaguugagucccauccugcccucucugcccacacuggcuccu
gcugcuauucuagugccucaaauaaaccguucacacccu
54 L00039 cuuccucccucuacagaagaagagcaagaagaugaggaagaaauugauguggugucugug
gagaagaggcaaaccccugccaagaggucggagucgggcucaucuccauuccgaggccac
agcaagccuccgcacagcccacugguccucaagaggugccacgucuccacucaccagcac
aacuacgccgcaccccccuccacaaggaaggacuauccagcugccaagagggccaaguug
gacaguggcaggguccuggagcagaucagcaacaaccgcaagugcuccagccccaggucc
uuagacacggaggaaaacgacaagaggcggacacacaacgucuuggaacgucagaggagg
aacgagcugaagcgcagcuuuuuugcccugcgugaccagaucccugaauuggaaaacaac
gaaaaggcccccaagguagugauccucaaaaaagccaccgccuacauccuguccauucaa
gcagacgagcacaagcucaccucugaaaaggacuuauugaggaaacgacgagaacaguug
aaacacaaacucgaacagcuucgaaacucuggugcauaaacugaccuaacucgaggagga
gcuuggaaucucucgugagagcuaaggagaacgguccuucugacagaacugaugcgcugg
aauuaaaaugcaugccaaagccuaaccucacaaccuuggcuggggcuuugggacuguaag
cuucagccauaauuuuuaacugcucaacuaaauaguauaaaagaacuuuuuuuuaugcuuc
ccacucuuuuuucuuuuuccuuuuaacagauuuguauuuaauuguuuuuuuaaaaaauc
g
uuaaaaucuauccaauuuucauguaaauagggccuugaaauguaaacaacuuuauuaaa
accuuaauaacasuuacaaaasauuuuaacacauuuuuuuuuu
55 D21099 guaggacgggccccccucgagggucgacccacgcguccgggaguacccccgaccuuagcugg
cgucugacuucgcuuccuucugccugcccaggcuugcacuccccggggaucugccuugc
aucucuugccuucucuguuguucccucucuguccagcuccccucccgcucucucccugg
agaauggcucagaaggaaaacgccuacccgugggcccuacggcucaaagacgucucagucu
ggccugaacacguugucccagagaguccuacggaaggagccugccacgacaucugcgcuu
gcucucgugaacuuguccaacagccaguccacagcuucccuggccagaaguuggcugag
aacaaaagucagaucuccacugccucgcaagggaucccagaacaagcagccuuucacuauu
gacaacuauugagauugggcguccuuuggggcaaaggcaaauuuuggaaacguguacuuggc
u
cgggagaagaagagccuuuucaucuuggcacucaagauccucuucaagucucagauugag
aaggaggggguagagcaccagcuucgccgagagaucgaaauccaggcgcaccugaaacau
cccaacauccuucaacucuacaacuacuucuacgaccagcagaggaucuacuuaauccug
gaauacgccccucgcggggaacucuacaaggaacugcagaagagucguaccuucgaugag
cagcgggacuaccacaaucauauaggaacugucagaugcccuaaccuacugccacaagaag
aagguauuucacagagacauaaagccggagaaccugcuguuaggucugcagggagaacug
aagauugcagacuuuggcuugucggugcaugccccaucccugaggaugaagaccaugugc
ggcacggcuggacuaucugcccccaaagaugauugaauggcggcaugcauaaugaaauagua
gaucuauggugcaucggggugcucugcuaugaacugaugguggguacccccccuucga
g
agcccuagccacagugagacguaucgucggauugucaaaguggaccugaaguuccccucu
ucugugccuucgggcgcccaggaccucaucuccaagcugcucaaacauaaccccuggcaa
cggcugccccuggcggagguucagcucacccuuggguccgggccaacucaaggaggguu
cugccucccucugcccuuuagccugcuccuugguuuuuugucccugucauuuuucagug
u
ucuuuguaugucuguguauguguucugagaaggggugggaacuggauacuauuccuagc
uccaguucuaggggaucuaaucucucuucugaccucuacaaucaaaauaggcaccccug
u
ggugcacaauaugcacgccaaacacauguaguuacaaacagggcaacaaacacacagaua
gugcuggagagauggcucggcauuuaaaagcacuugcugcucuucccaggaaccuagau
ucaauucuagcacuacauggugcuucacggccacugucuguaacacccaguccuggggaau
cuggggccuucgagccucugcaggcacuaggcauggaugugguauacauguaugcaggca
aaacacccaugcacugacuuuaagaaacccucuagucugauuccuuucaggguugucaaa
ugguugaauguuauuuuuaaaauauuuauaagccauuuaauacaaugguucuuugaaacaug
guauagccuagucugucuuaaaguucagaaaaauuaugaagaacaacauguuauaauaaag
ucuuaaauguuucauguuuuug
56 AF02648 Sequence below.
uugccuaggaagggcgcgucgucucuucugcucguccggcugugacggggaagggucccgcugcguuuuggucacuguga
uaccaaguuugggggauccccgagggacucucgagagcucauuuuagggaugcaggggcuacuccccggugguagagag
cuuucuaguuuugcaggauguuucguauuuggaggaguccagcuuagucauaaagcacauguucucagagaugaggacaag
acuaagacccuaaucccugaucuuuaccuuccuucccgcugaccugggccuggaugcuaaagcccucugcuuucgucua
aacagcgcuaaauaguauacaguauugccuaagauaaaugcggauuauuacccgauucagugucgggaaaaggcagcuagg
agagagcggcuguacgugguaagcacacgguaaguuucguuuaaauuuaaacaaccauccguugagcaucucuuagcaag
cuccuuccacccuucaaacaaucagugauaguacgucuguuucacugauggaugagcuaaggcuccaacaacagcaaagga
acuaauccgccucugaucaacauggcguuucuuacagggcauuccuuauacgcuuucccacgugcguaacaggaaucgggu
gugggcccuggguuuuguuuguuguuguuguuuuguuuguuuucuuagugaaagagugcagggugggcuccaggccgcu
gaggauuaauaaagagauucuaugaauaggaaauaacaggcagguggguauaacgagggcaaggcccugagaaaagcuuag
guggggugaguagaaccagagccggaaguccacucagcagccuggggcacuuaaagcuucugcuuggggcaaaugguuaagg
Cggcguaaggucacauuccuucauuucuuccagacucaggaggagaccacaccuuccggagaaccaggccugaaccgagg
uacuauuauuguagcucucagaauccaggacucugcaacacuguugggcugccuuggaucuucuauauucacaguuuccca
guugcuucuugaucuaccacuguuagauacuucugccacccauccuaagaguauaguuuguucuuggaaaggaguucucagcu
gcugucagcaggagucccucauucgacuccugugguugcccuuuccaccaugccaaagaauaaaggcaaaggaggcaaaaa
caggcgcagauguaaaaaugaaaauuaaucugagaaaagauaguuguguuuaaagaugaugggcaggaguaugcucagg
ugaucaaaaugcugggaaauggacgguauaaacaauguacuuuaacggugugaggaggcuaugccauauaagaaggaag
cugagaaagaagguuuggauaaauaccucggacauuauauugauuggucuacgagacuaucaagauaacaaagcugaugua
aucuuaaaguauaaugcagaugaagcaagaagucugaaggccuauggagaacuuccagaacaugccaaaaucaaugaaacgg
acacauuuggguccuggggaugaugauggaaauccaauuuggaugauauuggaggaugaugauaaagacauuggaugacaucuag
ccugaccuaagcaugcuaccuuccaaguuucucugaagauagcuccacacaguggcaucuugaccuucaucuguuaaguaaa
acuucauggcauguguaugacuuguuaaugcaagcuaaugaauuuugguuggaaguacuauauuucuuugaaaaccaa
agauguugaguuaucaucuuaaaugacauauuaacacuuugugcuuuugaauauaaugaaccuagcgcacagcaggugag
Cacuguuaagagacugccuuuccauuuguagcuucauuucuggcacgggaguguuuugugucagcagucugccaggugg
ccaucgaugagcugaaguaaguccuaguccagcacaucugcuucaggccuguacucuagucaucuggcugcguucgaga
cuucucagcagaacuuauagauauguacggcugcacuuggaggucagacaagauauggcuacuuuugguacuuauauagcca
ugccauuuuauacuuucacguuguauacauucguuuugacccuuuaaguuuguugccacccauaaaaaggcaucuuacaguugc
aguuuuuaaauuacauggguagcaauuuugaguuuuaaaaauuagucauugcagaaauuaaauacuuagaggagauaauc
cauuaucuugauuuuaggaauauaauaguugacaauguuuauauauaauuuuacuucucuaaggcauacccaaaaauagaa
aaugaaaaagagcagugaguucuguuucugaugcuugcauugcauagagaaguuuuccaacaaagcagcuguuaauaacacau
aaaauauguuuuacuuugcaaaguagguuguguuaagucauuuucaaaaaguuaccuacuauaucgaggcucuggauaau
uacuauuuguugauaauuuaguuacagaauuuacaagcuaaguuuuccaaacuaagcagaaaggagaggaggccaagga
aaccacagcucaaugaaaacacgguccuguuuucuaaauggaggcacccaaaaacacaauaaaacaugguuggacaaaaaa
aaaaaaaaa
57 J04596 caugaucccagccacccgcucgcuucucugugcaucgcugcugcugcuggccaccagccg
ccuggccacaggggcgccuaucgccaaugagcugcgcuugucagugccugcagaccauggc
ugggauucaccucaagaacauccagagcuugaagguguugcccucagggccccacugcac
ccaaaccuaagucauagccacacucaagaauggucgauaggcugccuuuacccugaagc
ucccuugguucagaaaauuuguccaaaagaugcuaaaagguguccccaaguaacggagaaa
gaagacagacugcucugauggcaccgucuggugaacgcuggcuucugacaacacuauaca
aucuuaugaggguccuauauauuauguaggggauuuauuccacaaaguguugguuu
uuauuuuacauuaauauuuaacaauguggauacauuucaucgaugguaguucaguucg
cuuguucaguuuaaagaugguaggcuuaaaauauggucauuaaaacuaauagggauuggga
gaccacuaagugucaaccacugugcuaguagaaggguguugugcgaaaagaagugcagag
ag
auagaguuuaguauuauguuuguauguauuagggugaggacaugugugggaggcugu
guuuguaugucuugaaaagaaugucaguuauuuauugaaaguaucuuucauauuuuau
ggucaacacgcacggugugacgcuucccuuggacauuuugugucuaguugguagcccaua
augggcuuuacauucuuuaacccuguuucuccuggucucgucucgcucgggacagagac
guucaaaggacuguuacaaaugaaguaaaaauaaaaguuuauuaag
58 X81580 cgucucccgcaugggcgucugggccgugcaccuggcccgcuagcucgcugcacuaccguuacc
cacaagccaacaugcugccgagauugggcggccccgcgcugccgcugcuccugccgucgu
ugcucuucugcugcucuugggcgcgggcggcugcggccccggggugcgcgccgaggug
c
uguuccgcugcccacccugcacgcccgaggcucuggccgcuugcgggcccccacccgacg
cgcccugcgccgagcuggugcgagagcccggcugcggcugcugcuccuugugcgcacggc
aggaaugcgaagcauacggcgucuacaucccgcgcugcacccaucgcuacgcugcuauc
ccaacccgggcuccgagcugccccugaaggcgcuugucacaggcgcggguaccugugaaa
agagacgcgugggcaccaccccacagcagguugcagacagugaugacgaccacucugagg
gaggccugguggauaccacguggaugggaccaugaacauguugggaguugguagcagu
g
cuggcggaagccccucaagucaggcaugaaggagcuggcuguguuccgggagaagguca
augauagcaccggcagaugggcaagggugccaaacaccucagucuggaggagcccaaga
aguugcgcccgccucccgccaggaccccuugccagcagggaguuauaccaaguccuggagc
ggaucuccaccaugcgccuuccggaugaucggggcccccuggaacaucucuacucccugc
acauccccaacugugacaagcauggccgguacaaccuuaagcagugcaagaugucucuga
acggacagcgcggggagugcuggugugugaaccccaauaccgggaagcccauccagggag
cucccaccauccggggagaccccgagugccaucucuucuacaacgagcagcaggagacug
guggggcccaugcccaaagugugcaguaaaccccagccagucggugccuggcuuccccau
cccgaacaccaacauaauagggcgucagggugacggguguagagggaguucccaguuu
ugacacauguauuuauauuggaaagagaccaacacugagcucagaagccccccucugacc
ccccccagcggcuguuauugaaccucccuugcuucuguuagagaggggaagggugguau
ggaggggcacuauguacaauccugggaaugggggaaagaaauuuuggauuuuuuaucccug
u
59 AI314958 gucucuuuuuuacuuaagauuaaaggaaggaaaaaauaaaaaaaaaaaaa
gaugugaaaaacguuuuuauuauaaucucuuaaacuuucaguguauauuuucauuacaau
cauugguacaauaaauauggaaaugcugagcagacagggaucacaguggccuaugggcug
agggacaaggacccaaauacuguuacccuggauacuuccucagggccaaucaauaggu
cuucaaagaguauugagagggagagggauagaaauauuauuaagacugucagugcagcaa
cuuggagaaugucuauuaaagccauggauacaggauuuacgauauagaagauggauacu
aaaaaagaacagagacucaaguucuccuguaagaggcagaagaaacauugcagaagccag
ugccuuccucggguccccagugugugcccccauccacccacgcauuguguuggucaucuc
caccugcccugugcccagcccugugcccacccagguucuccuaggcacccaccuugcacc
ucgcacg
60 AF0058798 gaauucugcgcaggguuugcauuuuauggggucagaagcuuuuuacauaaacgaagc
uccaacgacuagaccacagggaccgucguggcggccgagcagcguauccaacagg
a
gacagccaguucgccguaugucugucuauccuucacacagucauggagaggagccaucu
gauccagaaggccaagaggcugaacaggccgaacgguuaugaagacauggcagcuuacau
gaagaucgccguguaaaagggcgaggagcucuccugcgaguagcgaaaccuggggauccgu
agccuacaagaacguagugggcggccaaagagcgggccuggaauguccuguccagcaucga
gcagaagagcaacgaggaggggucagaagagaagggccccgagguugaaagaguaccggga
gaagguagagaccgagcucagaggugugugcgacaccguacucggccagcuggacucgca
ccucaucaaaggggcuugagaugcagagagccgcgacuucuaccugaagaugaaggguua
cuacuaccgcuaccuagccgagguggccacuggcgaugacaagaagcgcaucaucgauuc
ugcccggucagccuaccaggaggccauggacaucagcaagaaggagaugccgccuaccaa
ccccauccgccugggccuguccugaacuuaucagugggaccacuacgagauagccaacag
ccccgaggaggccaucucgcuggccaagaccaccuucgacgaggccauggccgaccugca
cacccucagugaggacuccuacaaggacagcacccucaucaugcagcuccugagagacaa
ccugacucuguugacagccgacagugcuggggaagaggguguugagucuccggaugaccc
ccacaucugaagcagcgggaaaaacaacccggguuagcuuagccuaccagguccccagccug
gcauagaggauuaaaagggagugggauuuugccgggucccaaacccugaauguucagcaac
accuugggaaguucuuucgaagguggcgcagccaagcugaagccaccagggcagugaauu
uaauauuucguguagcugauugauaggguggguuucccaaaaccaucccaccccuaugggu
u
gaacccccuccccaauucuucccccugagccucccucgggcaccuguugcuuuuggaucc
gaauaauccaauagguuccccacccuauggcugagaaauggacuguagcaagaucuguau
gugugugagagagagggaaacacugugugugugagugugagagagagagagagagugaa
ugagagggaaaaaguuugcugggugugaccaugguaccaaucaauaaaguugcccuguga
gacucaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
61 AW046627 uuuuuuuuuuuuuuauaaauaccaaaacauauaauuuaaauaccuguauaaaaaauaug
aucuucaaacauauucacauuauugaacuuauacaaccccaccccugauacuuagucacac
cagggucacagaaacacagcugcaaaaaaaaauuaagggcauugagauucugucccccaac
cccagcuuucagagccagcaagcagacuguacaaggucaauaauuuuuaaccccuccccag
cgcagagugcucagggugacagggucuc
62 AI848050 uuuuuuuuuuuuuuuuuuauguaacuaccggugugcuucauuuuguuuagcagaaccac
ucucuugaaucacauuaacuuuuggagauuuaaaaaaaacaaaacaaaaaaaaaaaaaaaca
acaaaaaaaaaaccaacccuccauagcacagcugucuuauaugcaagcaagagcacaccu
acuccagcaugauuugucaucuaaagacuugaaaacaaaacaacaacaacaaaaaguuac
uuauagucaauggauaagcagaguccaaauuuucacuaaucaaggacagaccuucgagggg
ucacgauaaguccggaauuuucaaaccuugauucguaugaauuguacuaucugaacauaa
63 AF065441 augaggacuccacagccucauccugcucuccuuccuucuccuggcuacucaagcguucuca
gaaaaggucagaaagagagccaagaacgcaccacacagcacagcggaggaggggguagag
gguucagcucccucguuagggaaggcccagaauaaucagugaagcaggacaucuaaaucu
cugacgcauggcaaguuugucaccaaagaccaagccacaugcagaugggcugugacgag
gaggagcagggcaucagccugaagguccagugcacacaagccgaucaggaguuuucuugu
guuuuugcuguugacccaacugacuucuuaaacacgacaaagaccagaucuacugguaa
cagguugcccgcacgcuacgcaaacagaaaaauaucugcaggaacaccaaggagugucuagg
aagaccagagugugcagaaagagauuuccagagucuaaccucaagcuggugaaccccaac
gcacguggaaacacgaagcccaggaaggagaaagcagaggucuccgcaagggagcacaac
aagguccaaguagcugucuccacggagccaaacagggucaaaguagacaucacacucaau
ccagcugcgacccagaccauggccauuagagauccagagugucuagaggauccagaugug
cucaaccagaggaagaccgcccuggaguucuguggggaaucuuggagcuccauuugcaca
uucuuccucaacauacaggcacaucauaa
64 AF022992 Sequence below.
cgggucgacccacgcguccgcccacgcguccggcggagcuucuggguugcgggccgaaacggcaagcggauggagggcgc
ucgaacggccaggugucgugauuaaauuagucagcccucagagacagucguccuaccuccuuuauccagaccucaaaagcc
ccauugugcacccgugguaucuucuucaccuucccuguuggcguccuccacuguauggcccagacaugaGGugguccccuaa
aaggggccgaugggggaggagaccccaggcccggagaaccuuuuuguccuggaggagucccauccccuggggccccgcagc
accggccuuguccaggccccagccuggcugaugacacugaugcaaacagcaauggcucaaguggcaaugaguccaacggac
ccaaguccaggggcgcaucucaacggaguucucauagguuccucuucgGGcaauggcaaggacucagcucugcuggagacca
cugagagcagcaagaguacaaacucacagagcccauccccacccagcagcuccauugccuacagccuccugagugcgagcuc
agagcaggacaacccaucuaccaguggcugcagcagugaacagucagcucgagccaggacccagaaagaacucaugacugca
cuucgggagcucaaacuucgucugccaccagagcgucggggcaugggccgcucugguaccuuggccacacuucauuacgcu
cuggccugugucaagcagguucaggcuaaccaggaauauuaccagcaguggagucuggaggagggugagccuugugccau
ggacaugucuacuuacacccuggaggaauuggagcauaucacauccgaauacacacuucgaaaccaggacaccuucucugu
ggcgguuguccuuccugacaggccggauugucuauauuucggagcaggcagguguccugcuucguggcaaacgggaugugu
uucgggguacccgcuucucaggagcuccuggcuccccaggauguggaugucuucuauggcucuacuacaccaucucaacug
cccaccuggggcacuggcaccucugcagguucaggucucaaggacuucacccaggaaaagucugucuucugccgaaucaga
ggaguuccugaccgugauccagggccucgguaccagccauuccgccuaaccccauaugugaccaugauucgggucucagau
ggagccccugcacagccgugcugccuacucauuGGccaagcgcauccacucuaguuaugaagcuccccgaaucccuccugac
aagaggaucuucaccacccgacacacaccaagcugccucuuccaggauguagaugaaagggcugccccacugcuggguuacc
uuccccaggaucuccugggggcuccauuacuucucuuucuacauccugaggaccgaccccucauucuggccauucauaaga
aaauacuGGcaGGcuggcaauccagcccuuugaccauuccccuauucggcuucugugcucaaacgggaaauaugucaccaugg
acaccagcugggccgguuuugugcaccccuggagccgcaagguggcuuucguguugggucgccauaaagugcgcacggca
Ccccugaaugaggacgucuucacucccccagcccccagcccagcuccgucccuggacucugauauccaggagcucucagagc
aaauccaucgauugcugcugcagccugugcacagcuccagccccacgaugcucugugggaguuacccucugauauccccug
guccucuacacagcccuggcuccuccagugauagcaaugggggggacgcugaggggccugggccuccugcuccagugacu
uuccagcagaucuguaaggaugugcaucugguaaagcaccagggacaacagcucuucauugaaucucgggccaagccccca
ccccggccccgccuccuggcuacagguacauucaauuccaaaguccuucccugccauuccccaaaccccgaacuugaggugg
Ccccaguuccugaccaagccucguuagccuuggccccugaggagccagagaggaaagaaaccucuggcuguuccuaccagc
agaucaacugccuggacagcauccucagguauuuggagagcugcaacauucccaguacaaccaagcguaaaugugccuccu
ccuccuccuacacugccucuucagccucugaugaugucaagcaugggcagguccaguuccugugggugccaugaaagauc
cgucgucagcaaugcuGGucugagagaggcaacuccucagaaggaggccagugggugggaagcacccugagcccgccacc
cuggccaauaaggcagagagcgugguguccgucaccagucaguguagcuucagcuccaccaucguccaugugggagacaag
aagcccccggagucggacaucaucaugauggaagaccugccuggccuggccccuggcccagcccccaguccggcccccagcc
ccacagguagccccugacccaaccccaggaugcuuaucgcccaguagucuaaccaaggccguggcugucccugcacacacagaa
ggaagagcaagccuuccucaaccgcuucagagaucuuggcaggcuucguggacuugacaccucuucuguggcccccucagc
cccuggcugccaccauggccccauucccccuggucgccgacaccacugccgaucuaaagcaaagcguucccgccaccaccac
caccauccccccggcccuaaacucccugcuauuucucccauccuucaccgggugcccucuucuggacccuggccacccccac
cagccacgacccccuucccagcaaugguccagcccuacccacucccaguauucuccccucgaggaggaccccagccccuuccc
ccugccccuacaucuguguccccugcuaccuucccuucucccuuagugaccccaaugguggccuuggugcucccuaacuau
cuauucccuaccccaccuaguuauccauauggggagucccaggccccuuuugaggggccacccacgccugcuucccacucg
cccucuccaucccugcccccaccaccucucaaccccccccaccgcccagacuccccacuguucaacucgagaugcagcucccc
acuccagcucaaucugcugcagcuugaggaguccccccgcacggaggggggcgcugcugcaggaggcccaggaagcagugc
ugggccccugccucccagugaggagacugcugagccauggccagauugguggagguuacugagucguccaaucaggaug
cacuuucagggcuccaacgaccugcuagagcuacugcuccaagaagacucucgcucggggcacaacuccgcagccucaacu
cccugggcucuggccugggcucugggucugguucaggaucccacgaagggggaagcaccucagccagcaucacccgcagca
gucagagcagccauacaagcaaguacuuuggcagcaucuacucuuccgaggcugaagcuggggcugcucgggccaggacug
agccugagaccaggucauuaaguaugugcuccaggaccccaucuggcugcucauggccaaugccgaccagcaugucauga
ugacauaccaggugccguccagggaugcagccucugugcugaagcaagaccgggagaggcuccgggccaugcagaaacagc
agccacgguucucagaggaccagaggcgggaacugggugcugugcacuccuggguccggaagggccagcugccucgggcc
cuugauguggauggcgugugguggacugugggcaacaacguucaagauccuggccacucugauggacccggcucuucucaggaacu
ggauggauuggggcuggagcccauggaagaggguggaggcgaggguggugggugugguguuggcggugguggggguga
guggggucucauccagcccagcuuuaccugcagaagaaaacagcaccagcuagauccauuuuggggccgcuuacagcaguc
uaaugagaggcuuccuuucgaccauguugggguucuuauaacucaagauacagcuggaccaaccaauaggaaacugcccca
gcuucucccaacauagggggcuggacccccauuaccagcccaggcacaggagcugccucuagcuucuuagcagaguggaag
uucucagccccauuuggaggauuguccacgcccgucccacuuaggagacgggcgggucuucuguuaagguugcugacaag
cugcuggaaauggcuguccaaaucccaGGcugagccugaaucccagucGGcaauguuggaucugcacuuauuuauuugggag
agacagcucacucucccaccucaccccaagaugggaggaggggaaccugggaucuguguaggauccagguccgugaacccc
uagcugcuccagggugggggagguugguggaccauggagucccuggugcugccccucaggugggacccagguuuucucag
cucuacccucuaccaaugacauuuguauuuggauauugugucuguuauuuuuuuuuuaauacaaaauggacaaaauggaaa
aaccaaaaa
65 AF064088 Sequence below.
gacagcggagcgcgguggcgucgacgucuagugucucagugcucccgucuguggcuaacuaagcagccagcagccaggcag
cucgcgaccuggcggccaggcagccaaccauggcucaacuucggcggcuucucuccagcaaggcuucggagggggaaaauggaacu
aauuucugaaaagcccagagaggggaugcaucccugggacaaagcugagcagagugacuuugaagcgguggaagcgcucau
gcaugagcugcgacuggaagucucauuucaagaaauaccuugaaaacaggccugucacaccagugucugauaccuccga
ggaugacagccuuccagggacgccugaccuucagacagucccagcauuuuguuuaacgccaccuuacagccccucuga
cuucgaacccucccaagggucaaaucugacugcaucagcgccaucuacuggccacuucaaaucuuucuccgaugcugccaag
ccuccaggcgccacuccuuucaaagaggaggaaaagaauccuuuagcugccccuccucuuccuaaggcucaagccaccagug
ucauccgucacacagcugaugcccaacugugcaaccaccaguccugccccgugaaagcagcuagcauccucaacuaucagga
caauucuccggagaagaacccacaaauguuggaggcuacucggaaagaacauacccugugcugcaguGGucaccaaacaga
ccaagccugagcccagcacaguguccgauggugaugagaaggcgggcgcugcacuauaugacuuugcugugccuuccuca
gagacaguaauuuguaggucucagccagcuccuucuuccccagugcauagucaguacugguuucuucaccuacaguaucc
acugggggagugccaccccugccugucaucugccagaugguuccccuuccugccaacaacucucuuguuagcacagugguc
cccagcacuccuccuagccagccaccagcugucugcucaccuguguuguucaugggcacucaggugccugagggcaccguc
guguuugugguaccccagcccguugugcagagcccaaggccuccaguggugagccccaguggcaccagacugucucccauu
gccccugcuccuggauucucuccuucaggcaggcaagggucacuccucagauugacucauccagaguaagaagucacaucugu
agccacccaggg-uguggcaagacuuacuuuaaaaguucccaucugaaggcccacgugaggacacacacaggggaaaaaccuu
ucagcugcagcuggaaaggcugugaaaggagguuugcucgcuccgaugaacuguccagacaccggcggacacacacaggug
agaagaaguaugccuuucccaugugugaccgucuguuuaugaugagcgaccauuuggaccaagcaugcccgacgccaccuau
cagccaagaagcugccaaacuggcaaauggaaguuagcaaguuaaaugacauugcucugccuccgaccccugcuuccgcaca
gugacggccagaagauggagacgcagaauaaacuuuggucagagucaggagccagugauggugucaagugcuucugcaag
gcuguggcccuccaaaagggccuaaaguagaauccuggccuuggggaggccccgccuggguuaaaugacaagaaguucuu
caaccacaggcaggucacagguggacagggcucaguucuuaccacagagagagaggagaacccuuuuauuccucccuuauuu
uagucuggaaaguuucggcugaggugagcgcagcacagguuuugaaucacauacacauuggggacuuuguuuuugccauu
uauacuagagaccagcuuugcagugugauucuuucaaaggauugguuucaagaauauagaggcuggaaauuugguacag
aaauggagcuagaaaaugaguuuaguuacacaggugaugucaucuucuccuagaguuaucuuguuucuuauuccuagucu
uuccagucaaauccguggauguagcuaaguauaucuaaaacucauuuuuccacuauuguugguauuugaaguugaacagc
uguacauugcugugggggagccaaaggauuggaacccucauuaagggaauugcuuggaaaugcagcuaaaauucuucuuu
agcauuuugguuuugaaaguuuaggcauuuuacucuacuuuagauuuugggguugcuugcaguuuuuuguguagauuugaa
aauuguauaccaauguguuuucuguaggcuuaaaauacacugcacuuuguuuagaaaaaaaucuggagaugaaaauaugua
uuauaaagaagagaugucaagagggugagauaacuccuugagaaaguuggcuuuaugucaucagcaaaggacacuuaacgu
caagcauacacuguggauuuuuuuguuuuuuuguuuuuuuuucaaauuagaaaguuuaaugaccguuacagauggccaca
gugucuuuuuauuuauaggaguuuuucaggaugucagaguagauagguaggaaaauuguuauuagaacauucgcuucuac
cuugaaaaggauguuaauguggucauguucuuagcaccacagugucugggcaucugggaaacuccgagacuuuuuuaaag
ugucaugaugugaucacaccugcaguuugggcaucgaauccagguccuugcaugucuucuguaagagcucucaucgcug
accuguaucccccgcaagagcaaugacuuuugcuaacaguauuucuuuucuguuguaaaguggacagaugauacacuugg
ucgcaaagguaaauuauucaaaauccacagugaaaaccucaccacacuuucccauuuaaacuauuuccauaucucagagguu
ucugacaugcaaacuugaacccuuuaagaagaguuacuuaaaaauuauaaaaaaucacgaguuacaauaugcacaauau
uuuuuguugaacuuuauaccuugguuuacaauaaaggacuuuucuuug
66 AI787713 uugucauuugcacgacagaaacugcaggaagaugagaugcgccgggcugcggaggagcgc
aggaugguaaaggcugaagaguuagcugccagacaaaggguucuagaaaaaauuuaagg
gacaaagcagagagagccaagaaguauggugguaguguggguucucggucauccccacca
gcaacagacccagguccuguuccuucuucucccagccaggagcccccuacuaagcgggag
uaugaccagugucguauacaguuuagucugccugaugguacuucacugacccagacuuuc
cgggcccgggaacagcuggcagcugugaggcucuacguggagcuucaccguggggagga
g
ccuguacaggaccaggacccugugcaguagcucaguggcuuccccaucuggcuuucuca
gagggcugauauggaacccucugcaggguacugggacucgugccuucugcuguccucauu
guggccaagaagugucccagcugaggguucuccaucccaccaucuc
67 AI853531 uuuuuuuuuuuuuuuuucacaaauaaguaauauaacuuuauuaaaaugaaaagacaauau
ucaaaauaaugcaacaaaaugaauaaauccuuuguccaauacuguacacacagugcggag
aucagugcauuuuucuaaagcauguuuuaaccuucauuuaguucauacuaaaguaagcuu
uaaauagcucaaauaaugucauucaacaguuuaaacugaacagcuuguuaugacaugaca
gcagugucccugcuagcaagcaccuucucuuuguguuuaucugcacaagauaaacaauca
gaguauguaaaaacunacacaaacugauugucucacugaaucucagggcaguuaagcag
ccagcgugaguuuucaaagcaggaagaugcugguaggugaccucuggcauuaaggacuuu
ugcua
68 X14678 Sequence below.
uucauuggaaagcacauugcucuucucaguaauuucuuuaguaucuucaugauuuuuuuccuuuugcgucuuuauuucag
caauucuaucugcagaucauaaagguaguauugacagaugugauucuuuuucuuaaacauuucauuuccaggguaaggaa
cucaauggcuauguuuuucucucccucuagugcauccuucuccuuuucuaccauuuucacucuauuggacuucaucaugu
ucagucuggccuuugguuuucuucauagcaaucuguucaacuucacccugcuagauuuaaaaucgauuauggucuaaguca
augccaugacuucuaaggagauuuccaacauuggaaacgucuggcuucuucccacggaugugguagacagaagugcuaucu
cuguaggcgguucuggauacauagaaguugcuguuaggaaggacuucguaaucaucuccuuccuuaucaauuaucuuuug
aaaaugaacuucuacaguacaacucugauuauccuuguguucaucauauuauguaucaguaccgauagcuuuuuugaccu
uauuuuuuaugcucgauagccaaacacaaaaagcauggaaucaauaacauuagauuuuccacugccauuugguccaauaau
acaggaaaagcgcuuauggaaaggucccacaaguuucucuccagcauaggacuugaaguuuugguuuacaauaugaguuau
Caugagacgaggagcuccagcuucacuggccauggcuggagguggggguggagggauacuauucaaaaucuccucuaaac
ucuuauccagcuccucaccuggaggcuuugcgggugcagcgcuccccucaccuacuucgccuacuacaacucccacca
ccuccucucgauacaagaccgagcucugucggaccuacucagaaagcgggcguugucgcuacggggccaagugccaguuug
cucacggccugggugaacuucgccaagccaaucgccaccccaaguacaaaacggaacucugccacaaguucuaccuccaggg
ccgcugccccuaugacucucgaugccacuucauccacaaccccaccgaggaccuagcucucccuggccagccccaugugcug
cgacaaagcaucagcuucuccggcuugccucaggccgcagaagcucgccgccaccuccaggcuuuucuggcccuucccugu
ccucuuguuccuuuucgccuuccagcuccccaccgcccccuggggaucuuccacuuuccccuucugccuucucugcugccc
cugggaccccugugacucgaagagacccuaaccaggccuguugccccuccugccgaaggucuacuacccccagcaccaucug
ggggcccuuggguggccuggcucggagcccaucugcccacucucugggauccgauccugaugacuacgccagcagcggcag
Cagccugggggggucagacucaccugucuuugaggcagggguguuugggccuccccagaccccugcacccccaaggcgucu
ccccaucuucaaucguaucucugucucugauugacaagugccuaccuacccaguauggaucagcuagaucucaaagagagg
acagggacugcucauugcuguggaaccugggacacuccucuaaguuaauaagucccaucuucuggacauuccaagaugca
auaacccauuucccuggugcugggcuggggcaggucccuaguuugcaaauucaguguuuggguggauccguuccuagggu
accuaagauguuugauggagacaguugacaguuggucuuccaggccccaugucuucuuuuguuuuugagauaggagcuuu
uuaugguaccccaggcuagcuuugaacucaauauaauccugccuuagccuuuuccaagggcugggguuacagguaugcac
cagccccucugcaacucuggucuccuggaaucuuaagugcugugaagagccggcucccacaauauauccuaauuuuuacu
agacccugauguucaguuuccgguggucgaugccucuccugauauccuggugcucaaauuucccuccuauagcaaauagc
caaagccauugccaaaucccuucucccccaaccagugggcccuuuauuuaugacgacuuuauuuauuguauuggagauuuua
uaguauuuauauauauugggucgucuacuccguuuuucuuuuuguaauguuaaaacugauacuguauuaaguauaugcua
uaauauauuaauauauugcu
69 AI854358 cggacgcugcagaccugaccgacgugcugugcgaguucgacgcggugcuggccgacuucg
cgucgcccuuccacgagcgcacuuccacuaugaggagcaccuagagcgcaugaagcggcg
cagcagcgccagcuucagcgacagcagcugcuucagcgacucggagagugcagacucauu
guacagggacagcuucaccuucaaugaugagaagcugaacuccaaccaacccucucc
agcucuccugcccuccgcugucacuccucggaaagccaaauuaggugacacuaaagagcu
cgaagacuucauugccgaucuggacaggaccuuagcauguaugugaagcaaggaguuugg
gguc
70 X67668 ccggggccaaggagaagucugcaaaacaagaggcuggaauuggccuuagcgagguaaucagu
ucucuuaggagguuagggaauaagucuuucucuggaggucugagggaagcgcucgugu
c
agauggccagguugucauagguaaggguaaccccaucaagccgcugggcaaaauguccucu
uacgccuuuuuugugcagaccugccgggaggagcacaagaagaagcaucccaauucgucg
gucaacuucgccgagaucuccaagaaaugcuccaagagauggaagaccaugucugcaaag
gaaaacucgaaguuugaagauuuggccaagagcgacaaagcuuguuauuacaggggagaug
aagaacuauguuucucccaaaggugauaagaaaggaaagaaaaaagauccaaaugcuccg
aagagaccaccgucugccuucugccuguuuugcucugaaaaucgcccaaagaucaaaauu
gaauacccgugccugucuauugagauacugcgaagaaacugggugagauguggucuga
g
cagucugccaaagagaaacaaccguaugagcagaaagcagcuaaacuaaaggagaaguau
gaaaaggauuuugcugcauaccgugucaagggcaaaagugaagcaggaaagaaggguccu
gguaggccagcagGGcucaaagaagaaugacucaaaaaaugaggaagaagaagaggaagaa
gaugaagagggggaagaagaggaugaagaauaaguggcuauccuaaaguguggaguauau
gugcucaggcaguuauuuugcuaauaauguaaauucaagcgcagcucaacauuagcucca
guaggaa
71 K02236 aucacgcuccuagaacucuucaaaccgaucucucgucgaucuucaa
ccgccgccuccacucgccauggaccccaacugcuccugugccuccgguaagggggacugc
ugacgggauuucugggagagcuagacaggcuuuuuggccccuccuuuaguaauuacuuu
a
aggguacgaccggcuaccccuuccgaaugaauucugaagcacuccugcuccuuuaaacua
guccuugagauaguggcucgccuacccgggugauuugccucaccuuccuaggagaacagc
guucagguacucccgggucccacucaaccgcgcucacugacugccuucuacuuuuagaug
gauccugcuccugcggcuggcgccugcaaaugcaaacaaugcaaaugacuuccuggcaaga
aaaguaaguuggaucuucucugccauuuccccgucacucuccuggggucccuagcccgcc
gcgccucgccuucccucccgugagcguucagguggugugccucugacaagguuucucgcu
cacguucaacucuucucuccccacaggcugcugcuccugcugccccgugggcugugcaaa
gugcucccagggcugcaucugcaaagaggcuuccgacaagugcagcugcugugccugaag
gggggcggagggguccccacaucuguguaaauagaccauguagaagccuagccuuuuug
uacaacccugacucuuucuccauaacuuuuucuauaaagcauguaacugacaauaaaagc
cguugacuugauu
72 X51829 Sequence below.
gcucuuaguuuguggaagauuacaugcgauaucccgucgaccccucaucccuuccggccgggacagccuuugcuacag
ccugugaaacauugcguccccggugccccacgccugagggcaacaugaacccgcuacuucgcggugcaguccgggacccacgga
ucgcuuuuggcaaccagaaccggcgcuucagcccccggggugacgugcagcccgccgcccagacacauggccccgagcccaa
gaccccagcauguccugcacuggagggacgcccacaacuucuaucuccuguccccacuuuggucuugcucagucgggccu
agagccggccuaaggagcccagaagucccagaacauggcuggcaaaaacaauaacaggaggcaaaucagauagguaggcugcgg
cucugcugacaccuaccccugucucugguaaccuccucccucauggggagacugaagaaaguggaucuccugaacagaguc
aagcagcccagaggcucugccuuguggaagcugaaaguuccccuccugaaacuuggggacuuucaaauguugaugaguaca
augcaaagccaggacaagauaaccuuagaggugaaggaaauggaacacacaacugggcaaggccacacuacaggcccgcuggccu
gcaaggggcugauaagaggcuuggggaggugguggcuagagaagagggaguggcugagcccgcuuaucccacaucacagc
uggagggugguccagcugagaaugaagaggauggagaaacagugaagacuuaccaagcuucugcugcuuccauagcuccg
agauacaaacccaacaccccugugccuuucuuggagagggcaaaacaucaagccacggaagaaaaaggaacagaaaacaagg
cugaccccuccaacucuccuucuucaggcucccacuccagagccugggaguacuacucuagagagaagccuaagcaggagg
gagaagccaagguagagacacacagaacaaggcagggucacccuugucggaaugcugaagcuaaggaaggaggaccugaga
caacuuuagucaguacuggaaaugccuuccugaaggccuggauguaucacccaggagaggacacagaggaagaagacaaca
gcgauucggauucagcugaggaagacacagcucagaccggugccaccccccauacaagugccuuccugaaggccugggugu
aucgcccaggagaagacacagaggaagaagacaacgauucagauucagcugaggaagacacagcucagaccagugccacccc
ccauacaagugccuuccugaagaccugaguguaucacccaggagaggacacagaggaagaaaacagcgauuuggauucagc
ugaggaagacacagcucagaccgaugccaccccccauacaagugccuuccugaaggccuggguguaucacccaggagagga
cacagaggaagaaaacagcgauuugaauucagcugaggaagacacagcucagaccgaugccaccccacauacaaaucccuuc
cugaagaccuagguguaucacccaagagaggacacaaaaaaugacacagaagagaaaaaggacagugagaauguggcccca
ggugacucagaaacagcugacucaagccagagucccugccuucagccccagcguugucuaccaggagagaagaccaagggac
guagggaagaacccccucucuuccagguggccuucuauuuacccggagagaaaccagaaucaccuugagcugcaccuaagc
ugccccuucaacugcagagacggcucagauuguucaaagcccccacccgaaaucaggaccccgaaauuccucuaaaagcuc
ggaagguacacuucgcugagaaagucacaguccauuuccuugcugucuaggcaggaccagcccaagcuacccgucgagguc
ccuggaagcaguugcacgagaucgaagccgcuuugcucaacacauugcccaggcagaggagaagcugggucccuaccuua
ccccuaauuccagggccagagcauaagcacgccuuagaaacccaucucuuccacaguccaagccucgcucuuccucugaaa
ccacucccuugacccaagaugugaccacacccucuccccuucccagagaaaccccuucgcccagccuguacuugagagggag
gcggggcuaagccugaguaguuuccuauuauuuauuuauuuuuuauuugaauaagaaauaaagccuuuuaauuuguagu
gau
73 AW048937 uuuuuuuuuuuuuuuuuaaucaucgagaaguauuuauugagcaccagcuuugguaucgg
gugugaggacucgggacaaugcaggaugcuaucccuucucaugaaacacuuacaaucuga
guagagacagggagggaaccacaauacauguucuugaagugcaggcuaaagguaaacag
uccagaccaggauguuacagaaacagggauguuaggagcuggagucagacccacuaagug
cu
uuaacacccacgauauucaacacuaagaaaagaucagccauugcucaguguccuaugagc
ucccuuagcccccaagacaccaucauggccuagcuccuuguacaacuacuacuaa
74 AV139913 cccaaaacccauucagcaaaguucccaaccucgacgaacuagcaguauuuaaccaguaau
agguacacuguaguauauggugaauacuguauuauguuucaguacuuucucccagauaa
uuugaaaacguuccaggagaaggcagcuuccuauaugcagcgugugcuuucuuauucuu
uuuuuuaauauaugacaauuauuugagaacccauuucuacuuuaaauucauuuucuug
aaagucaugauucuacaccuaccauuuuccuauuaaaguacuguauucaaau
75 M32490 Sequence below.
agaccgugaacgagagcgccccagagaagcgccugcaaucucugcgccuccuccaccagcaccucaagagaaggacacccgc
caccucggcccucaccucaccacacuccggacgcauuuaaucccacugcucaccagcuuguugguucuguaucgccgcgc
ucgccccgguuccuccugcgcgccacaaugagcuccagcaccuucaggacgcucgcugucgccgucacccuucuccacuug
accaaacuggcacucuccaccugccccgccgccuaccacugcccucuggaagcacccaagugcgccccgggagucggguug
guccgaaacggcuacggcugcuguaaggucugcacuaaacaacucaacaaggacuacaacaaaacucaacccugcgaccac
accaagggguuggaaugcaauuucggcgccagcuccaccacucugaaaggucugcagagcucagucagaagcagaccc
ugugaauauaacuccagaaucuaccaaaacggagaaagcuuccaacccaacuauaaacaccaaugcacauguauugauggcg
ccgugaacugcauuccucuguauccccaagaacugucucuccccaaucugaacugucccaacccccggcugguaaaaguca
gcgggcaguacugugaagaguagguuugagaugaagacagcauuaaggacucccuggacgaccaggaugaccuccucgga
cucgauaccucggaggugaaguuaacgaaaaacaauaaguuaaucgcaauuggaaaaggcagcucacugaaaaggcuuccu
gucuuugacaccaaaccacgaauucuuuucaacccucuacacgcccauggccagaaauacaucguucaaaccacgucuugg
ucccaguacuccaagagcugcggaacuggcaucuccacacgaguaaccaaugacaacccagagugccgccuggugaaagaga
cccggaucugugaagugcguccuuguggacaaccaguguacagcagccuauaaaagggcaagauaugcagcaagaccaagaa
auccccagaaccaggucagauuuacuuuuggcaagauggcuccaaugucaauaauaccagcccaaauacugcacuccugcgu
agauggccggugcugcacaccucugcagaccagaacuguguagaugcgguuccgaugcgaagauggagagauguuuuccaa
gaaugucaugaugauccaguccugcauauguaacuacaucugcccgcaucccaacgaggcaucguuccgacuguacagccua
uucaaugacauccacauguucagggacuaagugccuccaggguuccuaguuugggcuggacauggagaugucaugcauc
auggagacgugggugggcggaggaugaauggugccuugcucauucuugaguagcauuaggguauuucaaaacugccaagg
ggcugauguggacggacagcagcgcagccgcaguuggaguaugccaaggggcugauguggacggacagcagcgcagccgca
guuggaguagacuucgcuucauaguacuggagcgugcauuauugcuccauauuggaucauguuuucggaugacguucugu
uuucuguuuguauauuauuugcuaaguguauuuuuuugcuccagacccccccccccuuucuugguucuacaauuguaaua
gagacauauuaagauuaguugggccaagugaaagcccugcuuguccuuugacagaaguauaugaaagcgccucucauuccu
ucccgagcggagggggacucucugugaguguccuuggggcagcuaccugcacucuaauacugcaaacagauaccagguguu
uuuagauugaauguuuuuuuuuuuuucaaagguguaggcuuuuagggaaggaaggaauuauauuacuggaauuauuugua
aaugauuuuuauuuuauaucaguguagagaauuuauuuuuauauuuuaucauuuaauauagaauuauuuaccuaaa
76 AI121305 ccaauaccacagccgugaccacagccaagaccacagccaanagccuggccauccgcacuc
ucggcagcccccuggcagugcccuccauauccugcuuguuuuucucauuaguaaacuccu
cuucuaaagaaaacuggggaagcagaucuccaaccuccaggucauccucccgagcucauu
ucaggccauugcuuuacauacccgaaugnagguunaauguccucaguccgcagcuccac
caccuugaaccacaggaccugcaacacuaaugcacuugagaauacaaaugcuuaccugga
ucuuucagggcacanauuccucuucuuguaanuacuuaguccauccauccugcguagua
77 U35374 auggagaacgaguucacauacgaagauuaugagaccacugccaaguggcuucugcaacac
acuganuaucgaccucanguggcagugaucugugguuccggcuuaggagggcugacugc
u
cacuuaaaggaagcucagaucuuugacuacaaugagauacccaacuuuccccanagcaca
gugcnaggucacgcaggccgacuggugunugganugcugaauggcagaugcugugugau
g
augcaaggccgguuccauauguaugaaggauacucacugucaaaggugacauucccagug
agaguuuuccaucuucuggguguggaaacuuugguggucaccaaugcugcuggaggacu
c
aaccccauuuuugaaguuaagauauuaugcugauccgugaucacaucaaccuaccuggu
uucuguggccaguacccucuccggggccccaacgaugauagguuuggaguucguuuuccu
gccaugucugaugcuuaugaccgggauaugaggcagaaggcuaucagugccuggauacaa
augggggaacaacuaagcuacaaaaaggcaccuacgugauguugggcagggccccaacuuu
gagcuguggcagagagucgucuccuaaagaugcugggggcagaugcuguuggcaugag
c
acagucccaguaguuaucgucgcuaggcacuguggucuccguuucuuuggucucacuc
auuacgaacaagguugucauggauuaugagaacuuggaguaggccaaucacauggauguu
cuggaugccgggauagcagcugcacagacauuggaaagguuugucuccauucuuauggag
agcauuccacucccggaucguggcagcuu
78 X15643 Sequence below.
uuccaggacagcuggggcuccacgagagaaacccugccucccccccaaaaauggcccauaguucacugacauacucacauuu
gucuauauuuagcuauguaacagcacuuacgguagcauuagauuuugauucucucucaucacaaugauaauggcuggcgc
ucucucucucccucucuccccauuucauaucugcuagcacaccccuuugagauggagaGGaauuugauccauugggagaaucg
agcuaaaaauaccaccauggaauugugggaaggauuaaaugcaauaaugcacaaaaggcacauagcagaaugugcccuaaau
gucagccauuguuaugguauauguaaucuacaaaguauguuugcuuacuccgugugaaagacuuucagcuaucaaaca
uaauacaugugaaaucaaaccuugaaaauuaauuuuuucccaacagucaagacauuugccagcugcagagauuagcauuu
caugaaucuuagucuugucugauuuuuuuaaugggaaggaacaacuauccucaacuauccuuuuuuuuuuucuguaguuu
uaaaaugaacuccacaaaacaugugguaauauaggauuauaugaaauuguggggugggcagcgaggaaagcagaa
auagcccaaugguggcacauucacugacacagccuaaaagauuagcaaauacccauccaacacauacaauuaauacaauua
auauuuuauaguuaaaacagaguuacuaaagaaauuguugaaaagaaaauuaugaagacuggaaagacggcucagugcu
uaagagcuuuggcuagucuuccagagaaccagggucauccagcacucacaaggcagcuugugagcugauacuaucuguaua
uucaguccuagguaaucugaugcuggguccugaccuccaaaacaggcacaaauguggugcacaggcaaauguauagauaag
acucccaugcacagaacauaaauaacguagguuuaauuuuaaauuguaaaacugaaaaugguugcacuuacauuuuuauu
ucagcacauccccagauauccgccauauaacaagaaaaugaugccacacucccaagaauuaagagggacaccucccaacccu
acccaaauuuguauacucuaggucuaaagaaaugcaaaggaugaaguuacugccuugugaguucucaaggagggaggau
accaaaaaaauauuuuuucacaaaguggugcuggagaaacucuguaggcuguuggagucaucuccugugcucuugccaaauaac
ugaaaggggauacacuggaugucugugaauggggugucacuuaugagugcuagaagcggguaccuggauguggacacggu
gucugagugguccgcacuccauucuccacaggaucgcuuauuguguuucuuuccuccugcuucugguuguuccuggu
uuuguuuacagccaccucucuguuggaccagggagacaacugucgucuccagaauaagcgggcacagguguGGucucggugg
cuguggcugugguucggcauaagucugagcauguccuggucgucagggugcguuugugcugugugugcguguccgggug
agcuugcucuuucuguuccuaaaagaaaaugcacccugcgcuaccggcguccagagacucucagcccgcagaggugaccug
aacggacagguaacaccuccagacaacgccuggguuggcggguugcacagcaGGccccagauuucucucucugggugccccagc
uaggguagcuggaagggagcgguggccuggccuccggggagccgcugggccccgccgggcuaacccaggaggaggccggc
uaggcugggaggguuagcccuuggugcccuacgccugcccgggccagucgcgccgccggccauuggcccaaagaauugu
ugcacgucacuggcaauccccuauaagucuuugcacauaacggucaggacacugcaaggcuucuucucccgcauuuag
gcugcggcugcaggcaccgcgagcccggagcacccacgagcuuagugugcaggacgcaccccagcacagccaccuacggccg
ugaaugaagcuuccaguguccgcccccggccgucgccccgucguggugcacccgcugagagcgccuggaccgaaaggc
cgguucgcucaccugcuaaccugccagccauggggccacacgggaacgacagcgacuucuugcuggcacccauggaagcc
gagcgccacaccacaacgucacucaaaacgggacggaaggcgugagugugacauggccauccucaugucauuaucgucc
uaaucuccuuggcgugugcugaucuauucaugggccuagcguuggugccguuuggggccagucacaccucuaugaaaaug
uaauuuuggcaacuucugguggcgaguucuggacuuccauugauauuguacgucacagccagcaucggagacccugugg
cgugauugcaguggaucgcuauguugcuaucacaucgcccuucaaguaccagagccugcugaccaagaauaaggcccgagu
ggucauccugaugguauggauuguaucuugccgaccuccuugggccuauccagaugcacugguaccuugccacccacaa
gaaagcuaucggauuguuacaccgaggaGGacuugcuggugacuucuucacgaaccaagccuacgccaucgcauccucggauugu
gucuuucuacgugccccugguggugauggucuuugucuauucccgggucuuccagguggccaaaaggcagcugcagaaga
uagacaaaucugaggaagauuccacgcccaaaaccucagccagguggagcaggaugggcggacgggccacggacuccgaa
gguccuccaagguucuggcuugaaagaggcacaaaucccucaaugacuuuagggcaucaucaugggcacauucacccucuggcugg
cugcccuucuucauugucaauaucgugcacguuaucagggacaaccucaucccuaaggaaguuuacauucuccuuaacuggu
ugggcuacgucaacucugccuucaauccucuuaucuacugucggaguccagauuucaggauugccuuucaagagcuucug
ugccuucgcaggucuuccuucgaaaccuaugguaacggcuacucuagcaauagcauggcagauggacuacacaguggag
ccaaacacuugucagcuggggcaggagagagaacaggaacugcugugugaggaucccccaggcauggaaggcuuugugaac
ugucaagguacugugccuagccuuagcguugacucccaaggaaggaacuguaguacaaaugacucgccacuguaauacagg
cuuucuacucucuaagaccccuccuugacaggacacuaaccagacuauuuaacuugaguguaauaacugagaagaaauu
gguauagaaaggguacagaagggggacacauccuucucgccuguuuuaauuuauguauuuuaggcugcaaacaaaa
gagagaacuguauuugagugcuuauuguucuuguauaguucaguuccucuuguauggaacuuaaagguuucugucugaa
gaguguuuguucugaggacugagucugucugucugucugucugucuuucugucuggaugauguuuucauguaucuaccu
cacuggucaaguauuaagaaugauauauauugcuacugggaaauccauaucuaaaggagaaaguuuucuuccuguacccuu
ggacuugaaauauccugugucuuggaccuuucugcugugacaaugggcccuuucucucucacuccacuuauuuacucaaa
uggauucgagggcaaggauuugaggagacaacacuaguuguuuuguuuuuguuuuuguuuuuguguuugguucguu
aaaguuuacaguaaauaaauuguuuaaccaugacuucauugcacccguuucuucaaaaccucuugacucuggaguguccuu
gucucucccacuggaaaccacagguaaacuaugugucgugaccgaugaguugcuuaauguguaagaguaccagaauggcau
gcuugcaugcaccgugccuagcccuuccgugugugucuucagagcuccagaugcaaaccugugccuucccuaacuucacuc
gugucccaaagcaguccugccuguucacagcauaacccaguauguccuacaguugcucuucugugcugucacuccagaaac
ccugacucacggaaacagaguuauggacauauguuuuuguccccauaugcucugacaccaccuucagccuuacuucuuaa
uaacuguguauauggacaucacugcgucucuuacaguagugccuuuguacugcaucagggcuugguauguucaggaugag
gaagauguucuguguaauagcuguucaagcaucuagaaauucugagggaaaucaaaggccucggucagagagagagagaga
gagcaaagcuuuaaaaaacauagcuggugaaugcuucacgcccuucagccucuccucgcuccgucugcugucccgugucuu
cuguucccaauucucugcacuucuguguaaaccaggcuucccaugucuggcauuccgugcauuauaugauauuuggcggc
acgucuguaccaguaaauucugguagcacccccuaguuacaauaauugcagacacucagcgcguacgacccccuaguuacau
augcagacacu
79 AI849109 uuuuuuuuuuuuuuuuuaagcguccaggcuguacuuuauuuuacacaagugguggcccc
agaaccacagggacaugaccuggagaguaggcacagugccugaggcugcaagagccaaaua
cagggauucaugccuucuccuugguccccaugaccaaauuaaaaaaaaaaaaaacaacaa
aucacacagcacacaucgccacacccauccccuccuuccuuucagcaacagccaauucag
cuuucuagccaaagacaguggcuacaacugaauuuacagagaaccaugcagccaagaaac
cagagccacguaggguagaggcuugcguugacuucccacaugugcugucccauagcagcu
gagugaccccacca
80 U70132 agaaagauaagggccagcaaggaaagaaugaggaugugggcgccgacgacccauccaaga
agaagcggcaacgccggcagaggacucauuucacuagccagcagcugcaggagcuggaag
ccacuuuccagagaaaccgcuacccagacauguccacucgcgaagaaa:ucgccgugugga
ccaaccunuacggaaccccgaguccggguuugguucaagaaucgccggaccaaauggagaa
agcgggaacgcaaccagcaggccgagcugugcaagaauggcuuugggccgcaguucaacg
ggcucaugcagcccuacgaugacauguaccccggcuauucguacaacaauugggcugcca
agggccucacaucagcgucucuguccaccaagagcuuccccuucuucaacuccaugang
ucaauccccuuuccucucagaguauguuuuccccgcccaacuccaucucaucuaugagua
ugucguccagcauggugcccuccgcggugaccggcgucccgggcuccagccucaauagcc
ugaauaacuugaacaaccugagcagcccgucgcugaauuccgcggugcccacgcccgccu
guccuuacgcgccgccgacuccuccguacguuuauagggacacauguaacucgagccugg
ccagccugagacugaaagcaaagcagcacuccagcuucggcuacgccagcgugcagaacc
cggccuccaaccugagugcuugccaguaugcagucgaccggccggugugaaccgcgccca
gggcgcgcggauccgaggacugucggagugggcaacucugccccagaaagacugagaauu
gugcuagaaguucgugcgcacuaugggaaggaagaggggggaaaaaagaucagaggaaaa
gaaaccacugaauucaaagagagagcgccuuugauuucaaaggaauguccccaagugucu
acgucuuucgcuaagaguauucccaacaguuggaggacgcguacgcccacaaauguuuca
cuggauaugacauuuuaacauuacuauaagcuuguuauuuuuuaaguuuagcauuguua
a
cauuaaaaugacugaaaggauguauauauaucgaaaugucaaauuaauuuuauaaaagca
guuguuaguacuaucacuacaguguuuuuaaaggcuaggcuuuaaaauaaagcauguuau
acagaaucaguuaggauuuuucgcuugcgagcaaaggaauguauauacuaaaugccacac
uguaucuucuaacauauuauuauu
81 M13805 cugagaggccaggugggcggcgaaaucaacguggagauggaugccgcucccgguguggac
cugacccacauccugucagagaugcgugaucagacgagaagaucacggagaagaaccgc
aaggaugccgaagacugguucuucagcaagaccgaggagcugaaccgcgagguggccacc
aacagcgagcuggugcagagcggcaagagcgagaucuccgagcucaggcgcaccaugcag
gcccuggagauugagcugcagucccugcucagcaugaaaccaucucuggagggcagccug
gcagagacagagaaccgcuacugcgugcagcugucucagauccaggggcugaucggcagu
guggaggagcagcuggcucagcugcgcugcgagauggagcagcagaaccaggaguacaag
auccugcuggaugugaagacaaggcuggagcaggagaucgccaccuaccgccgucugcug
gagggagaggaugcccaccugacucaguacaagccaaaagaaccugugaccacccgccag
gugcgcaccauuguggaagaaguucaggauggcaaggucaucucaucccgggaacaggug
caccagaccacccguuaaggacucagcuccuuccgcccaguuccccgaggcugcagagag
gcagcuucccucuccgcuccggcaucacccuccugcuacagccucuccccagcauuccua
ugcuugagaccauuaaagcuugcugaccugaagugaacuguggccuuuguucugaacacu
gaaauaaaugaccauggugac
82 AV138783 ccccaggggugaaaugaggauucccccacccugcggaacagugaaauguguauaauuaag
aggagggcgacgacccuugccgcgggacccgggacucgagcccgggacuucgcagcuaca
gcaaaucuauuuuuaauauugugcugagcaagacagaucgcuugcauauuuuuaaaaauu
uuuacuacagagacauuccaauaaauucguuaagcc
83 K02927 Sequence below.
cugacagucgucucucucccuucuucaccucgcagcugcuaacuggucucaaaccucucagcacuucagcuucuagccacg
augcaugugaucaagcgagauggccgccaagagcgaguuauguuugacaaaauuacaucacgaauccagaaacucuguuau
ggacucaacauggacuuuguugauccugcucagaucaccaugaaaguaauccaaggccuauauaguggggucaccacagug
gaacuggacacccuggcugcuaagacagccgcgaccuugaccacaaaacacccugacuaugccauccuggcagcaaggaauag
ccgucucuaacuugcacaaagaaacaaagaaaguguucagugaugugauggaggaucucuacaacuacauaaauccgcacaa
cggcagacacucucccaugguggccagcucaacacucgacauuguuauggccaauaaggaucgccugaauucugccauuau
cuaugaccgauauuucucuuauaacuacuuuggcuuuaauacacuggaacggucauauuuguugaagaucaauguuaaag
uacaaccuacuuucugagaagugguucacucaugccccuccuacucucuucaaugcugggaccaaccgcccacagcugucu
agcuguuuccucuugaguaugaaagauuacagcuuugaaugaauuuaugauacucugaagcaguugccuugauuucuaa
auccgcuaggggaauggauguugcugugaguugguaggcgggccacuggguagcuacaucgcuaggacuaauggcaauucu
aauggccuugugccaaugcugagaguauauaacaacacagcucgcuauguggaucaagguggaaacaagcgcccaggcgcg
uuugcugggguaccuggagccuuggcacuuagacaucuuugaguuccuugacuugaagaagaacacagucaaggaagaacag
cgagcacgcgaucucuucuuugcacuuuggaucccaggaucucuucauaaaacgaguggagacuaaccagucuggucauug
augugucccaaugaguguccuggucuggacgaggucuggggagaggaguuugagaaguuauaugaaaguuacgagaagca
gguucguuuccgaaaaguuguaaaagcucagcagcuuugguaugccaucauugagucccauacggagaccgguaccccaua
caugcucuacaaagauuccuguaaccguaaagcaaccagcagaaccugguaccaucaaaugcagcaaccuguguacaaaa
auaguagaguacaccaguaaagaugagguugcaguuuguaacuuggcuucucuggcucugaauauguaugucacaccgga
acauacguaugacuuugagaaacuggcagaagucacuaaagucauuguccgaaaucugaauaaaauaauugauauaaacua
cuacccuauuccagaggcacacuuaucaaacaaacaccaucggcccauuggaauuaggguacaagguuuagcagaugcuuu
cauccugaugagauaccccuuugagagcccagaagcccaguuauuaaauaagcagaucuuugaaaccauuuacuauggagc
ccuggaagccagcugugaacuagccaaggaguauggccccuaugaaacguaugagggaucuccagucagcaaggguauucu
ucaguaugacauguggaauguugcuccuacauccuguuggacuggaagccucucaaguagaagauugcauaguauggua
uaaggaacaguuuacuuauugccccaaugccuacugcuucaacugcccagauucuggggaauaaugaguccauugagccuu
auaccaguaacaucuacacucgaagagucuugucaggggaauuucagauugugaauccucacuuacugaaagaucuuacug
agcggggcuuguguaugagagaugaaaaaucagauuauugcaugcaauggcuccauucagagcauaccagaaauuccuga
ugaccuguagcaacucuauaagaccgugugaaaaucucucagaaggacuguucucaagauggcagccgagagaggugcuuu
caucgaucagagccagucuuuaaacauccauauugcugagcccaacuauggcaaacucacuaguaugcacuucuacgguug
gaagcaggguuuaaagacuggaauuuauuacuuaaggacgaugccugccgcuaauccaauccaguucacucugaacaagga
aaaacuaaaagauaaggaaaaggcacugaaggaaaggaggagaaggaaaggaacacagcagccaugguguacucuuugga
gaacagagaggagugccugauguguggauccugagaaaagcggggccugggagacgcagcgggcucuccuuccgagagg
cagacgauuugagcauagauaggauauuggguuugcuuuuguuaucagcagcucugcuuggacgugccugccaggacaggg
aaccacaacuuacaguacuauuucuacacaguguaaauaucauuuuaacaaacagaaaaccaaagccagcuuugauauuag
gaaucaagguagaggcuuugggaauacuaaagagccuuccugcaaauagugaggagacuuaggaagucucgucucuccagc
uuucccugccuggccauucucaguuugggcaaagagauuuaguuugauuugacugauugccuagaaguaaaaucaagcaa
uuacucaucaggcuaaaaaccuuuggucuagacaaacuucuauaagucauuuugaaauaaacauuucuaagugau
84 X07699 Sequence below.
guguggcuuccgcugagcucuuccgagcugcucgcucuccacacgcgccgccgccguaauccgccaccauggugaagcucg
cauagguaagaggccuuugcgcgccgacgagacgacuagucccugcuuucggagggacgcgcgcgcgcccgcccguccg
ucgcggaagggaagagacucgcgcaaucccgggcgcguucgagggcaccaugcugggaggaaaggucucgcgcgacu
agcgggaggucucgcggugcuugcccucugacuuagggggaugagaagagcggaggcagguuuccgggagggcgauaucg
aggguucggauguaugggcgggaggggacguugugaggagagaucggaggagcugagagcggauaggggcacugcgug
agaagaggagggccaaccuuaggcggcggagcagucccaggccccgccuccccgcggcacgugcucuagugcgcgcccgccac
gugcucugcggagccccgcacgugucgcgcgacccggggcagugggggagugucuguaguaccccggaaagggggacggc
agcguggggauggauggguggcccggcgaucugcugucucugccggugaccgggauggacacgugguggaccccugagg
ucggcgugguggacuccacauggugggggcuaaaacgagaggaaaguggaaaacaguuggguuacgugguggcugcuuua
agaggugauuucgagauacccccuuccccagcaaauaacuuaaagggaucccuuuaacuggguuuuuuuuuuuuuuuuuu
uuuuuggguuguggaagaugccagaaaauagauggccaggauuaggagacuuuauaaccuguggcuguuucuuggugu
agaguucugucugcucaguuaucugugagaaguaaaaaaaaauuaugcgcgguucgcagaaaaaacuuccaggagaaugcc
augccuggccaagaagaagucuuuaugcuuguguccuuuaguaagaaaaaggugguggccaaaggcaaagugacugaaaau
gcgugcaauuuuugugugcguuuguaggcuggcaaaacccacggugaggccaagaaaauggcuccuccuccaaaggaggu
ggaagaggauagugaagaugaauaaaugucagaagaugaagaugacagcauuggauaagaggagguaagaagcuauuuca
acgaauuaaaccggugggaauugaaugucuggaagucuuaaaaauacaagauauguaguaaaugguugaauacaagcccc
uuccucccucccucccucccucccucccucccucccucccucccuuccuuccuuccuuccuuccuuccuuccuuccuucugc
aagacagucgucaaaacaggggacagaaacaggcagaauuuugaguuccaggcaagcagguaguaguacauagugaaaccu
ugucucaagaccauuguuauggucauggcucaaucagauuucuuagaaaagcucaagugcugaguccagagguuugggguuu
uaaaguauugaaagccaugucuccuuauuucaggguuuaauguuuaucuuugugugugcgcgcacccauuaagcaugcuu
gguacccucauacuagaauguacuuggauccccuggaacuugaguuaaagccacaugugaauguuacauguuacaagagua
acacaugugcuuaacuuuugagucaucucuccaguucuugguuauuguuuuuuuugguuuuaagccuaucuaaugucca
uuuucuugugcucaaaguuagucucuuaauguagcauuggguauaaaggaaugcuuaugauuuguuugcuuucaagguu
gucaucccucagaaaaaaggcaaaaaggcuaccacaaccccagcaaagaaggugguuguuucacaaacaaaaaaggcugcag
uucccacaccagcuaagaaagcagcugugaccccaggcaaaaaggcagguagccacaccagcuaaaaaaaacauuacaccagcc
aaagucauuccaacaccggguaagaagggagcugcacaagcaaaagcguugguaccaacuccugguaaaaagggagcugcca
cuccagcuaagggggcuaagaacgguaagaaugccaagaaggaagacagugaugaggaugaagaugaagaggaugaagaug
auagcgaugaggaugaagaugaugaggaagaugaugaguuggagccaccaauaguaaaaggagugaagccagcaaaagcag
cuccugcugcuccugccucagaggaugaggaagaugaugaggaugaagaugaugaggaagaugaugaugaagaggaggaa
gauggugaguuagaucuuaggauauuuaggguacugcauguacauucccucacuguuucauuagauuaaaaacucauuuu
gugcucuuaguucuuuccauaacuuaauagguuuucauuugcuaaguaguuuuuguuuuuuuuaaguauuuguagcauu
uaucuuaucuaauuaguaagagcaaauacauuugccuggauuuggccaucuuucuuccagacucugaaaagaaguuaug
gagaucacaacagccaaaggaaagaaaacuccugcaaaaguuguuccuaugaaagccaagaguguggcugaggaggaggau
gaugaggaagaggaugaagauuacgaggaugaggauuaugaggaagaggauuacgaagaugaugaugaugaagaagagua
ggaaggguaaccauauuaacuuuuaaaguaugcugaccuaagguaaggcuuacuggcuaugcuaaagugucuacuuacucau
gaauggcauuuuaaaacaucuagaaccuguuaaagcagcaccuggaaaacggaagaaggagaugaccaagcagaaagaagcc
ccugaagccaagaaacagaaaguauaauguaagccugcaaaacuggguaaacagaucagaguagcacuagcacaauugauua
guggacaaagggacuuaauacuaaaccauggaggugaaaugaaauaugcugauggugcuuuauaguuuaugaugaaauuugu
aaaccuuaauccaaacaagucuguuaaugaauuaaaauuugccaucagugaacuuuuugcuaaaaaugaucuugcuguugu
ggaugucagaacugguacaaauagguaaauuuuaauuuauguuacauuguaucagcuagaauuggggaguuuccaguua
acaguuaaggagcugcaguaagaaagacuauaguauugaacuaaaugaucgagucauagggccugcaauuugaaguuccug
uguuugacuugauaaagauaaaauaaaauuuggagaagaaaagauauugacacauaaaauuuugugcaguaucuacaacu
auggaucugcauagucauaugcuuuuagcuaaaaguauucucuguacuuuuagcgggguccaugcuagcuacugcuguua
guuacaauauacugaaugaagaaaucgaggugaauuuguuguaaugucuugguacauggacuuguuuuguuuuuuguuu
uuuuuucuuuaagauuuguuuauguauauuagcacacuguaucuguccagaugguuugguagccuucauuugguuguugg
aaauugaaugggguaggaucucaacucgcucugcucucagguccuugcuugcucuggcccaaagauuuauuuguuauuauac
auaaguacacuguagcugacuuaagaugcaucagaagagggcauuaggucucauuaugggugguggugagccaccaugug
guugcugugauuugaacucaggaccuucagaagagcagucaaugugcuuacccgcugagccaucucuccagccuuuggacu
ugguuuggauggaaggauaagggugaucuagguuuuauuuuuguuaguacuguagaugcucuguggugugugccacaugguau
aagugcagaucaccuucucauaccuguaaucuuguugggguccaucuucaaggaaauuugguuauguggacugagucug
cugaagaccuagaaaaggccuugggagcucacuguuaaaaguguuuggcaauaaaauuaaacuagaaaaaccaaaaggaa
gagauaguaagaaagguauguaagggggucugggugacuggauacuuaacagacuuaggcagucuggugccucuuccuuag
ucauccucauugugaaccaaugagaugucauaggucaugugcuuggacaggggugauuccugggauauauaauguc
agggcugacaggaggaauagcuuagugaguaaagaugcuugcugcaaaaugggugaucucuauaagccacaugaagagaga
agaaccuuuaaucccagcauuugggagacagaggcaggcagauuucagaguucgaggccagccuggucuacagaguugaguu
ccaggacauccagggcuacacagagaaacccugucucggaaaaaaaguuuuagcuuauccucugaccacauguguaucgug
acaugcuugaagcuuaccuaucucaaauuaauucuugaucccuauaugguaguuucagaauuuggauaggaaguguu
uguuucuuaauugugcugaaaauugaacgugggcuuuucacauacuaggcaaauuuguuggguuuuuuuguuuguuuuu
uggcucaagacaggguuuuucuguguagcccuggcuguccuggagaccaagcuagccuugaacucagaaaucugccugccuc
ccaagugcugggauuaaaggcgugagucaccacugcccugcuaggcaaucacucuuaaaacugcuacauauccucuguccc
cuuggugcucauuuuacaagguugcuguguacucaaucuggcacuaugauauacuuacuagaucuagggcuuuugaua
uagaaugaaccauaugagugaugagguaucuuagagauggaaacuaagucuaaauagacuuguuccauauacaacuuaua
cauauggucuaaggaacaugauauacauguaaacaaguaggaaggagauaagucugguguccagggaagccaggagauccu
caucugaaacuaacaggguugugagucaucaggugacaauugaacauggguacucuucauGGcaaauaguuaauaacc
au-ugagccaccucuccaucccuuuauaccauuuuuuuuuuuagcauauauccuuguacuuuauaggaauuauuugcuuua
aucucuugugacuuguaaauugauguacuuaauuaaaucuuuccaacauaguucgagcugcaagaacacuucuagccaa
aaaccucucuggucaacaucacuggaggaugaauuaaaggaaguguuugaagacgccauagagaucagauuagucaggccagga
ugggaaaaguaaaggguaguuuugugucuuugaguguuaaaguuuuauuaaguuuagugucuucuuuccccucuccuugu
ccuugacagucucuagucugcugcuucaaacaacuucauaaccagaaaauugaauaucugguccucuggccucuaccuc
ccauuuucuuacauuaaaaaugcucaacuuaugguuuuagaaggugugaucaauuuuacaggcucaauccaaagggcauc
uuuugccacaauacuauccuucccuauuuuaugagagaaaugugauucuaggcaguuuucagucuuauuguguuggcucuuu
uuccuccucaccaguuuaaaggaugaagaugagcuaauacauaguaaaagaacaguaaaagcacaugugacuaaguccuuca
ugucugauucuugaguaauuuuucucuauguaguaacugaauugucuuguacucucaggauugcuuauauugaauu
uaagucugaagcugauacagagaaaaauuuggaagaaaagcaagggcagaaauugauagacgaucuguuucacucuacua
gugggaacaggaaucauuuguaucuuuguaugggaaguaauugggggaccuacaauuaguucaccuuuguucauauagcug
auguuuagucuucaugaggugaaagcuauuugaaaucauuuccuuuggaguauaguaggcaaauaaagcuuuuuguuagu
auguuuuguacuuuaaauggcuuaaacuauuuuagaaaauaguguaagacaacaaagaacaguuaucuaauuagaaugaaa
augaaaggaucaguaaggcauuacuguauauaauggauauacacugguggggcuagaauuaugguauaugguacauggu
ugaaguaccauugguuucaguuaacauuccaguaaccuuguGGgauggagguuagagacaugcuuuauagguggacccacuuac
ugaguguuuaaauauacacagacauacucuaacauaccuuugcuaauguguuaucuuuguauuugcaggugaaucaaagacuu
uugguuuuaaguaaccuuuccuacagugcaacaaaagaaacucuugaggaaguauuugagaaagcaacuuuuaucaaagug
ccccaggaacccacaugacaaaccuaaaggguaaaauaauuuuuacguuagauaugggcuggacauacauacucuuacguau
aagaguuaagacuguccuguuagcuuaaaaaaaaacuaaaguuuuagcuauacaaagggcaguaaauauugauaguaaauua
caugcugaugccaagugggucuaagcuuuauucugagaacugacuuucaaccuucagguaugcauuuauagaauuugcuu
cauuuuaagaugcuaaauaaucuuuaaauuccuguaauaaaauggaaauggagggcauaacaaucaggcuggaggggcaag
gauccaauucgagaagucguaaguccuuugacaugauaugacuuugguugggugauuuuuuuuuuuauuuuuaugugccu
auaugcucauuuggggcugucuuuauguuguugcugagaaaaugacaacuggauaugaugacugauuaccugagaaauaa
uuuaugaaaucucaagaaaauuccucuagauauucaaguucugauccagcuaugucaacucaaagcagcaaccugguugc
ccucugaguacgcuuuugguuuugauccaguGGuagucuuugguuuuuuuaaccuuaauuucuuguguuaauuacuuuuucu
gguaaaagggggaaaaaagacauaacaaaaucaguguaagggaaggcucagugguugagcacugagaggaccuggguuca
aaucccagcacucacauggcaccuaucgaguaggauuucucuuuguauuccugccugucguggaacucacucuguagacc
aggcuggccucaaacucagaaaucugccugccucugccuccuaggugcugggauuaaagggugugcaccaccacugcccaac
ccugucuguaacucuuaagaucugacauagauugcagacaaaacacuaaugcacauaaaaaaauuuuuuuuuuuaaaaaag
gaaucuacuucagcugaaugugggcagguaugggcaauauucaccaagauaucauaaugaaacagggaauuuuucucuuccagaa
ccauccaaaacucuguuugucaaaggucugucugaggauaccacugaagagaccuuaaaagaaucauuugagggcucuguu
cgugcaagaauagucacugaucgggaaacugguucuuccaaaggguaagaaggcguaguaguguugcugcuuuuuaguga
auucuucauggaguacuugguucugcauuaucuucucauugagcuccuuucuguccaucagugauagauuauggauucgc
acgagaagaagagagaauucacagaacuggcacuuaucuucuguuuuugcagaaguauauuuggcuguugugugagacau
uaugagauacuggcgauuuucucgaccugaagaguacuuuggucacucuacuugggugacuugguacuuauuguguuacu
uuaaaauuuguuuacuuaaugggugagguuuuuuuguuuuucuuuucuuuuuuagguuuguuuuuguagacuuuaaua
augagggaagauggccaaagcugccaaagagggccauggaagauggagaaauuaacggaaacaaaguuaccuugggacuaggcca
aaccuaagggugaagguggcuuugguggucgagguggaggcagaggagguuucggaggcagagguggaggcagaggugg
aagagguggauuuggaggaagaggccggguaggcuuuggagguaagguagggaaagguacuggaaacggauuccuaaacc
uguguccuaaccaaccaccuuaaaugggggaaagucaguccuaauugguaucacccuuugauguuuuuccuuccuauagguaga
ggaggcuuccgaugcggcagaggaggaugggcagacuucaagccacaaggaaagaagacgaaguuugaauag
85 X57800 Sequence below.
uuagacgguuggcgcgcgcagaggguugguaauugucgcugguaggccuucgcugccgcuucuggcaucguggaaucgggaga
ccuuggcagccagaccucguuccucuuagaguagcucucaucuagucgccacaacuccgccaccauguuugaggcacgccu
gauccagggcuccauccugaagaaggugcuggaggcucucaaagaccucaucaaugaggccugcugggacgucagcucggg
cggcgugaaccugcagagcauggacucgucucacgucuccuugguacagcuuacucugcgcuccgaaggcuucgacacaua
ccgcugcgaccgcaaccuagccaugggcgugaaccucaccaggugagcggguggcgggagcggggccccacucuucccgcu
uccgcucuuggcggggcugugacucugcacgcucauuggcuggcuuggccauccgcgcuuucugauuggucuauggugu
cgggggcagcccucaccaaagcgcgcgguuccgaaaagcccgucuggcauuggcuccacucuguuuccgcgccaaagcc
acaaagcaggagguccacggggaaaauaaguggcuccggagcugugcucauuaaaugccuacagcuuugaguagcuaucuua
gcgccuaauaaacgagucuuagugcaaauguaaugucgacuuagagugacaauagaccuuuucuugacuuccagagucuca
cugcgcaucauggauuugaguggaaaucugucaguuuuagcuuuuaacuuugcuacagcuaccuagguuagugccuccug
uauacguauucaagaacaguguaugacuuauuuuaguacagauacauggauuaguGGccacuuguauacauuuuaaaagau
uuacgaaaaggccagacgugauggggcacauucuccaguacacuagaaaccaaggacaccccgcucaaaaagaugcuuucuc
gaauguuggcuuuuagugcauuuuacuaauucgguuuuaagaaucacauauacccgguaauuugcuucaccccugagaga
auuuggaggacccuuaggccccuuuaacaguucuccaaccggugagugugaaauaguacaacuuauaauugcuuuuuaaaau
auagauguggauuacauguugauaaagccugucuuuuuuuuuuugggggguagcauguccaaaauucuaaaaugugcug
guaaugaagacaucauuacauuaagggcugaagauaaugcagacaccuuagcacuaguauucgaagcaccaaguaaguuaa
acaccuuuaaaacucggaguuacguguuguuucuguuucucaaaaccaaaaaaaauauuaacaauauuguaaauuccauca
uagauaggaccguguggugugcuugguaacauuuuccuucuuuugguagaucaagagaaaguuucagacuaugaaaugaa
guuaauggacuuagauguggagcaacuuggaaucccagugaguuaccuuguuucugauuguguguuacccugcugugaua
ccagcugaugcguuuucuuaguguaguguugguauuggggaugaauguacacugccauuucacuaaaccacagcagucu
aaaguugauugaguuuuaaagaaaccagaagucuugcauucugaguucugguuaagaugcuaaaucuugagaacaugaag
cugagccuucccccuuuucuagacugaccuuuaacuuguggguuuacaggaacaggaguacagcuguguaauaaagaugcc
gucgugugaauuggucacguauauuccuagaccuuagccacauuggagaugcuguugugauauccuuugcaaagaaugggg
ugaaguuuucuacaaguaagagcuuggcaauagaacauuaaguugucacaaacaaguaauguaauaaagaagagGGag
gcggugaguaguaagggggcguccaguuaggugucugaagcagggauggagccucggcuuuuguuuuuauuuauucauu
cauuuugagaugagucuugaguagaccaagcuaucuuagagcucagaucuacuccauaagcuuuuacagguagcauuu
ggaaagcuaagguguacaggccuuuugcuuccuggaaauacucuuagcaaauaagugaagguugggcaagugagcaaaagaaaa
ugguuggggguguauguagcuuuauguguugcagguucaagaguauuugcagucccaagggaaauaagaaagacuucaca
aaauguggaaagaguuguauuaaaugcucuugacaguuacauccauagagaaagcugggcaugaugucucaaacccacaac
ugauguacucaaagcuacagcagaaaaauucucagcuuaaagucaaccuggcagaaaaucuagcucaaaaagaauguagaag
aaauugggaaggcaaaggaagauguucuccgaguccuccucauucaaguagaacauacuaggccucuuuaauuucuaagua
ucccugaaucggaggcuuuuucucaggaauccaauguauauuucauggcuacacuuuuuuuuuucuuuuuuaaauuuugcu
agcuagccugagcaucagaauuacacacagaagucugaacuaaauaggauuuuuaggguuuaguauagugaaauucagagu
gcuucugcaaguauuuaagguaaauauaagguguuacuuggccucugcaugaaggggaaaguaaaugaaaguguaagaauu
cgaacauagauaaacacacaacccaagaacuaguucuuaaccuuaaucugcugaauuauuucuacuuccauaucaacuucag
cuccucaguucucaaauacugacauguaauucaucaguauuugucugaugugcaagcauuuccacaacaaaagaaauuaag
gaauuuuucaguauccacauguucaaggauugggaauugaauaaaauugauaaucauacaaugaagacugguuuacugucc
cuuagcuugcauucaucuguugguucuuguuuuuggaagugguuauuuguuaucuuccucucuucaugcauucuaugca
agagaaguauggggcaaucuggaauaggaacaacuuucuccuuuauuuugauugcuuggggguguggcucuacaggaugggca
agcuagacuuggggucuucuuuagucaagguuuucaucaacccuuccaaaaugauaacuauuuguuuugcuuugugguaua
auaccgugaucuaauagugugauuuucugaugucuacagugaucuguauucuccucuagguaaccauaugaugaauga
accuguucaccuaacauuugcucuggagguaccugaacuuuuucacaaaaggccacuccacuaucuccuacaguaacacucaa
uaugucugcagaugugccccuugguaagaugauaaguuugaacauuguuuuguaaugugguauuuauaguauucggugg
uuggauuuauccugucuuucaguuguauaguauaaaauagcugacaugggacacuuaaauuauuauuuggcucccaagau
ugaagauaaggaagcaucuuaggcauugcuaggaaauugagaaaacuaaaccuuugaagauugcuccugaaaugccagcggug
uccugaggucuuuucugucaccaaguuuguaccugaguauucuuaaauauuaaaauaaaauauguagauaucuucuguaa
auaaccuacuuucuuuucucuccauucuccauaauuugcuuaaagaauaagcuccaaaguaaaaacuaguuuuguuaacau
aaauguuucugcuuggcaaauacuagugauuuuccaucaaugaucuugacgcuaaaugcaguuuuaagaaauauuguuca
auuuaaauaaaguuaacaauuugaaaaguca
86 M35247 Sequence below.
ggugcaggauguaggccugcagaauugucagacccaguggcggcuuuugccacuggaagaauuuccaacauaaaacaga
ugaucauuuugggacaaucgauucugcgaccagagguauugucauuuguuuacuauuaaaauucauauugucuggug
uuuuccaaucacucgcgacugguaauuugaaguuagguucugaggauaauacaaucgcuggucgcucuaguuuauaaaacu
guccaagaucugcccagucccagauguccuggguccucagggccgcuguggucugccaacuucugcagcuggaugcca
gaccauccuggacucggaucccuauggguauuucuacaccgcugugucccguccuggccuaggugagcccugguucau
aaucgucgacuauguggacgacaugcagguccuacgcuucagcagcaagggaggagacuccgaggauagcacccugGGcu
ggagcaggaggaagcaggugacugggagcagcagacucguauagucacaauucaaggacagcugucugaaaggaaucu
gaugacccuuguacauuuuuacaacaagaucauggacgacucucacacacuacauuggcugcaaggcugcgauguggag
ccaggaucggcaccugugucucugguacaaccagcucaccuaugauaacgaggaucuccccacccugaacaaaaacccaag
uuccuguacagugggaaacagcacuguaccucacaucucucaggaccugaagagccacugcucagaucugcugcagaaa
uaccuguaaaaagggaaggagaggcuucugcguucagacccuccaaaggcacaugugacccgucaccccagaccugaag
guggaugucacccugauguugacccugacuucuacccugcugacaucacccugaccugggcaguugaaugagaggg
agcugacccaggacauggagcuuguggagaccaggccugcaggggauggaaccuuccagaagugggcagcuguggugg
ugccucuugggaaagagcagaguuacacaugccauguguaccaugaggggcugccugagccccucauccugagauggg
agccugcaugguaccaaaagccuuggauauggauuguugccaugguuuacauuuuguacaucauugguucucugugug
guuugcauaugcaugaagaagaaugcaggugggagaggaaggcgugacacccaagaagcaggcagagacaguccccaag
acucuagcaagacuguuguggaugaugaggagauggggguuugcuuuuggaagauuaaguccuguaaaacuugucua
ggccacuccccaggaacuucaguuggcgagucuuuacugucaccuugacuggauuuaggaucaucugugagaugcccc
uuugaguggcugggcugugaggacagcaaccaguucuugccacccugggacagaaacacaucucaccuuucuggcuca
aggaucugaacaccugucucuugccuacucggcuucuagucaggcauuuugucaccuugucaagggucccagggacac
aaagcucccuccucucacccacagcacucuugguccuacccucagugcuucagggacauauaaucaggucaaauuggga
ucaaugggcuuuggaugcagaaaagaacuguggacuaauagagauaggguuuaauuaaaaaauauaucuuuuuaauuuu
87 AI553024 cuggcacagacauggcugucuucugucugcugugugggaaacgcuuucaggcacaaagcg
cacuccagcagcacauggagguccacgcaggcgugcgcagcuauauuugcagugagugca
accgcaccuuccccagccacacggcucucaagcgccaccuucgcucacauacagguuuuu
uucuccaugugucaccaagugaaguuugugccuucuauagcaaagagaauauugggguaca
uccuacuaacaguagauuuuuuguagugaacauuuuuuguauuuuuauuuauaagucuc
auaagaaaaauagcgauguucaguuguauaccuugaaucugcaguuagaagagauuaaag
uuaacuc
88 X16995 Sequence below.
ggagccccagugcaggaggcugcgaaaguugggggagugugcuagaaggacugcggagcggagcgcacgcgggaccaggc
ugcgacugggucgcuggucccggccacagggagugggagccggcuggguagguaccccgcagggagcguguuucuguuuc
uagggacagugcaugaaagagaugagguguacgcgcaggcgaaaaggaaagguguuuucggaucggcuuacgaggaggg
guguguagggugcauuuuugguauuaaaggauagcucuuggaguagggugagccagggcuugaaguuuaggaagcgggc
gaagggucugcaaggugcuugguuuugguagguagugggcgcuuguuuaggagguuuccccgcuaggaucuccagugug
aggcacucuguacucugaguuuggauguugauugccggguaggagguugucugagcauggacuggaaaaagguacucag
agcuucggcguugcuggggauccauccaaguacaaguaagauuggauuuccacgggucuccucccggcucucagcccccu
uucccaguguuacuuaauacuucauaggcuguacuuagauuuucugauucccuuaccgaacuuucuuucugaaccgugc
uggaagaccuagggguuacugaaggaaauggccagcuagguuggcuagguaaugguuguguuagacuaaguugucagag
uaucuagaaaccuaggagcuguagccuggugcagcuacugaaagccgcacguggagccuggguggaaguugcucacgaua
gagucucgauguaguacugacuaggggggagaccccuucugucaucagacagacuuguauaccccaguggucuuuugaau
cuguuagguaggguacaaccugcgagcuuagucaccuaacagguguugccaggaccugccccaagccggauucucccacuc
ccucuuucaaccccgccucuuccuccuccuugagacacccccacccccucaggaggcuagaugcagaucuguaucuugugu
ugaauggagcuggaacaaacgcccaguccugacugcugccacccuucuuccuccacccccaacccaucccuucccaggcuuc
uugcaaacagaggcagaaguggccauauuucuuucuuucucccaggugcuguaugcccuagggacuugacacggggcagg
cggggugggaacugguugggggggacgugcuguuuuaugggaagucguaugccuagccagcgguggagcuguccuggc
uaggcacccaggggugguguggggaaugggagaaauacugggacuagagggucucaagggccagcagguggugauagucu
uuuucuccaccccacccucugcuccaccaccccucugccucagcaccccucugcccucagcaccccucugccucagcacccuc
ugccuccagccacccucugccucagcacccucugccucagcacccucugccucagcacccucugccucagcacccucugccu
caguguuccugugugaccugucuuuucaacuagaaagucuagaacuguacagaccccagaguuggagguggaaagggacac
uagguccuggagccuccucugugggcuuuuuugaccagaugagaacguaagggccuccuccagcuaucccuggucauuca
ggugcuucagguuugugaccuuugcugagacccuggaugcugcagcaaacagacaucugcuuuagcagagggacagcuug
ucucugugcauccgcugguaggauccuccacucuguccaauuagcuugcgcugcugcuggguucugaguguucucuuaca
aaaugacaagguuagggggcuggagagauggcucaggggcuaagagcacccauguggcaguuuacaacugucuguaacuc
cuguuccaggggggaucugacacccucacacggacaaacaugcaggcaaaacaccuauuggcauggaaaaugaaaauaaaug
accggguuagcugagaaauuccuuuugagaguugucuuuucuccaguccaggacugcucucuggaucuuccugcucaguu
ccucgccucccuuccauauaugguauuuaaggauacuuuuuuuuggcguuuucaauuguuuuuaauuguauuuauaug
ugucucugugugugcacaugagcauggguguccuacaaggcuagagacaucagauguccuggagcuagaguuacagaugg
uugugagccaccugauguaguugcugggaacuggauuuaguuccuguggaagagcagugcaugcucuuaaccacugagca
acuucuccacuggcccccccccaguauacgguauuuaaaacucuauagcaaugcuacccaacccauuguggagcugggga
uggugagguggccuaguuccccccaacuccuggaaacaugucagaaaguacagagugggugccugugggaucagcaugcg
ggggguggugguggugagguguggggcugcuuucucccgaggcuaccgugauagacaguuguaccuugcuggcagccuc
uaccccauuuccaggaugucagucucugcagacguaugggggacgguggggaagggguauacagagccaugggugugccu
aggaauguacucccaggaaaugacugguugaaaaaucagcagaucuccuggaggauagagggguggacugaagcucugug
gguugccucucucagcccugaccugugaacagggaggcuggggguuggaggaacacagcuucccccuguuccugggggga
caugcuggacagccuuuccuagcucccccggcccacugggguguggcuggucgucggacugagcuugguuggaccugguc
ucugccugugagcuuugugacucguugagauagcauuuaggcugagaauuagagucuucguucuuuuccugaca
cccgcuuccuugucuaggccugccaccuggcuccccccaccccccuccccggccuaccaaguuucuugcuucccuuacugac
cccuccuccucccuccuuugugucuccucccucuccagagaugcccuguaggcaagcucaauauggaacaccagcaacgagc
ccaugaccgcgugaccaccugaccggugauccccuggcccuugaguucggcaagccuaccauggaccuggccauccccuag
acagcaccugccgcaccugcuacacugcccagcuucagcaccuucauggacggguacaccggagaguuugacaccuuccucu
accagcugccgggggacgacccagccgugcuccucagcuuguuccucugccuccuccacgucuucuuccucauccucggcca
ccucccccucuucggcguccuucaauuggugaggacuuccauguguuggcugcuacccgggcacccuuagcggcccaggag
augagacccuauccuccagcagcucugaguacuauagcagucccuacucagcccccucgccaucuacacccaacuuccagcc
gucccagcuuucucccugggacggcucauuuggccacuucuccccgagccagacuuauuaggccucugggcauggacaga
gcaguugccuaaggcuucuucauggccuccgccaccuccaaccuucuucuccuucaguccucccacuggccccagccccagc
cuggcccagaguucucuaaaauuguucccaccaccaggccacccaccagcuugggggagggaagagcuauuccaugccagca
gcuuuccccggcuuggcacccaccucuccgaaccgugacacuuccggcauucuggacgcacccgugaccuccaccaaguccc
ggagaugggcuucagguggcagcgagggccgcugugcagucuguggugacaaugcuucgugucagcacuaugggguccuc
accuguGGagggcugcaaaggcuucuucaagguauuuuguugguucuggggaacaaugauaucauguuggagguggggggu
ggagugggucauccguugggaucuguagugaccucuccugagguuucuucccagcugguucuguccugcaggacgaggga
caggugugugccaucuuagaggcugggacuuuuuauucagcaggggcacacaucucucuagggcugcagaaagcuggggaa
aggggcagaaggguguguguauguguaccugcagugguacucagaaacagaaaaccuaguagcagccucuaguucucca
cagaacuuguguuucuggcacuggaugaaaggacacaggcagaggguuugguucuugcuggggguggacuugggaacag
gcugugugggugucccagugcuggggccugcuuggcuuuucccaccuccauccccuuaguccucuccucugcgccagga
aaagggcaguuggacacauucagacaccuguuagaacagguuucuguacggccgugggaguuccuagacccuggucuugg
gggcugggaucuucccugugagguugaaaccuucuccaguaucucccagacuccucucugcgcucuggcccuccguuucu
cccucccccuacauccaaauguuaggaaaauagcuaugaacagagggcgcuuuugucuggucggccacaggaucuggacg
guccccuccccugggcucuccaccccccccccaaaccccaugcucugacagccuguuccguguccccccuuccuccagcgca
caguacagaaaagcgccaaguacaucugccuggcaaacaagaauuggcccuguggacaaggaggcggcagaaccgcugccagu
cugauggggugggacagccgggcucaccaggaucugcaccuaauucccacucccacuucuagauuccagccccuaaaugca
gguauagcuuccaccuacuuucuuaaaggguaggugaggaaggccuuguagguccccaucauggucugaguucucu
gucucugacuucucagagugggsuuguauagugugcccugaagacccuccuucuccaggucuccuggcucaauacugccc
ggucucugcaguuguacggacagacagccuaaaagggaugcggugccggcuaccuucaaaacccaagcagccuccauaug
ccuccccuaccaaucuucucacuucccucauccgggcacacuuggacuccgaccuagcacugccaaauuggacuauuccaa
ggugaggucuugcccgcccaucugcccugcccugagaacauaugcaaugccuuugugccuguuaggaaaggcucucccucc
agggcaacaucaggaaacaagcauccucuauguacuggcuaguuggagaaaugcauugggauggguguggggucggggag
ccauacaaacagcugccguagcccugguuuuccuguagaauugacaagcacauggggcccaggaauagggcucuuuugcac
gccuggaucuggugucccagugcaugagagcucuguaaugcagcuuguguaggcuuugcuguggacccaaugcaggacac
agcugugugaugcaggccuugcuguggagccagugcgugacacagcuguguggugcaggcccucauguggaacuuaccug
cguuccuuucaguuccaggaacuggugcugccccgcggcgugaaggaagaugccggugacguucaacaauggggaugacuu
gcucucugguucccuggacguuauccgaaagugggcagaaaaaaucccuggcuucauugagcuuugcccaggagaccaaga
ccuguugcuagagucugccuuccuggaacucuucauccuccgccuggcauaccgguaagcugcccaccauccuccuagccc
uguccccagcccuucggccccggccugccuggacccugaguccugacuguucucugccuucugccagaucuaaacccguug
agggGGaaacucaucuucugcucagaccugguacuacaccagcugcagugugcccguggcuuugggugauuagauugacaac
auccuggccuucucacggucccugcacagcuuggguguugauguucccgccuuugccugccuguccgcucugguccucau
cacuggugaguggcagaaacuagacugggcccaaggguugcaggaccauuggguagguagcaucuaacacuuuguggacc
ccuagagugccugcaacauugggauguuaggaccugcaaagggacuuagcucuauucgccccuaaagcuuaaaucagccuc
cgaaugaccccggacuccucagguacgacuguaggcgcugggcaucuagcuuagggaggcuggguguuuaaaaaccuagc
ugucaaccucacaagacacaggaacggugcacacaugaauuuuucacauucugcgcuuggauagcuaucgccauauccaga
aacaggaccuaccagcucugaugggcucccuccuuauugucucuguaagagguaaccacucugccagccucaguggcau
uccugucauggauuuuacugugcguaucacaggauggacucuaguguuaaauguagaggggucugggucccggcucg
uuccgccccauuuccacuuaaauuucggaggggauccuccugaguagaucaagaccaggagcuggaucuugaaaggguag
ggagugauaucuacacccagcucaguccuuagucuguccugcgagacuccaggaagguagaacaguguggagccuggaccu
ccagaaaaccuggauuaggcugggggccuuggccagccauucagugguuucaaauauugaccagucuggacagugggcucc
ugugggacgugcuauagggcuggguaaucuugucagggauaggcgucaacugagcggggcugacucuaccuucccugcu
acagaucgacacgggcuccagcacccucgucgggugcaacagcugcagaaucacauugcuagcugucugaaggaacacaug
gcuaccguggcaggagacccacagccggccagcugccugucacgucugcugggcaaacugccugagcggcggacccugugc
acucaaggccugcagcgcaucuuuugccucaauuuggaggacuugguacccccuccaccuauuguggacaagaucuuuug
aacacauugucuuucugaccccugcccugaacauggugugcgcacacguccgugcucuucugucacccauaugccuuuaagc
cuauagcccacggacccccagaccacccuacccccagccugggguugagcuaagacugacguaccuccucacuccagaagau
ggacagagaacucaauccugggggaguguguguauucacuggggugaccccacuauuugucuuaucccuccagcucagu
ccuggccggcccaguguuuuuguaagauaaaccaugguggaacacauaccacucuguuguaaauaaacugacgcuacuguaaa
uacagaaaggaagagguugagauggggguugggaggaagggguggggcucccaccagcugggcgagccuccaacucgaga
ucucuuccgcucuccuuccauguguacauaacugucacucaagaaggugauugacagauucugauggauauuuguguauu
uuccuggauuuauaggaugugacuuuucuaauggaauauauuuaauauaggcaauaaaaaauagacauguagguugaaa
89 AF038562 ggcacgaggcugugcccgccaugucugcuacccaucacaagaccucccugccucagggcg
uccgcuugggcacugucaugagaaucuaggcuuggucccugaccaggcuggcagguucc
auguaaaccuacuaugcagugaagagcaaggaacaaaugcccccuugcacuuuaacccga
ggcuggacacuuccgagguugucuucaacaccaaacaacaaggcaaauggggccgugagg
agcgaugcaccggcauccccuccaugugggcagcccuuugaagugcuccucaucgcca
cagaggaaggcuucaagacuguaguccaggauaacgaauaucuccacggccaccaccggc
ugccgcccgcccgcguucgcuugguggaagugggcggagacgugcagcugcauucauuga
auaucggcuaagcaaaggacccaagggccggugcccgguuacggguugggggugguuuga
ucccacaaaaaagguuuuggaucgcccaauaacauuuggcuguuguucgaaaaauuggaa
aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
90 Y1666 gccacauuguugcaccaacuccagugcuggagucucaggacaccaca
ggcuacccggaguuguucugcuuuggagauccgagggcaggagcaucacgccagugacuc
uuuaggugcgaucgccggauuggaacagaacugucauugguuuggccgaaguugagccuaa
gugacccaggugaggugaaguuaacgacgaacacuaagcagcuaaaccggucggcaggagu
gagacuuaggguaccuucuuaguaguugugauuaaaaaaauugaaaaaaagaaaaaaaaaa
acccuguggcuggaaacgggaggcccucagcuggugagccaucguggggaagcuucuuug
uguggcccuggagucuucgacccagccggacacccgggccugguuucaaagcggucgg
acagcgcugccugcuccaucgguagcgcucgagccucgguuucucuauuuggccccgacu
cgccgcaacaagaugaucgccucgcauaugaucgccugcuuauucacggagcucaaccaa
aaccaagugcaga
91 U40930 Sequence below.
cccaacuguuucguccauaccuagaccgcgguuauggcgucgcccgcacgaugauggccuaucuucugggcaaggaagag
g
cgacccgcgagauccaccacuucagcuucugcuucagcccggagccggaggcggaagcccaagccuggccggcccggg
g
cccugcgagaggcugcugagccgaguggcuguacuguuccccacgcugaggccuggcggcuuccaggcgcacuaccgc
g
augaggauggggacuuauugccuuuuccagugaugaggaacugacaaugacuauguccuaugugaaaaaugacaucu
uccacaucuacauuaaagagaugaaggagugccgacgggaacaucgcccaccaugugcucaggaggcaccccgauacau
ggugcaccccaaugugaucugugaugguugcaacgggccuguggugggaacucgcuauaagugcagugugugcccaga
cuacgaccugugcagcgugugcgaggggaagggccuacacaaggaacacagcaagcucaucuuucccaaccccuuuggc
caccucucugauagcuucucucauagccacuggcuucggaugcugaaacauggacacuuuggcuggccuggcugggag
augggcccaccggggaacuggagcccacguccuccucgugcaggggauggccgcccuugcccuacagcugagucagcuu
cugcuccaccagaagaucccaaugucaauuuccugaagaauaugggggagaauguggcagcugcccucagcccucuaga
cauugagguuaacauugaugugaaacauagagaaaagaguagccgccuaacacccacuaccccagaauguuccaacaca
ggcacagaagacaagaguaacacucagccaagcagcugcucuucggaagucagcaaaccugacggggcuggggagggcc
cugcucagucucugacagaacaaaugaaaaagauagccuuggagucgguaggacagccagaagaacagaugaagucgg
gaaacugcucaggaggaaacaaugacuaaacacauuuaucuucaaaagaaguggacccaucuacaggugaacuccaguc
cuauacccacaucucccaccagaggcuaauccccggcugauugaaucccucucccagauacuguccauggguuucucgg
augauggcagcuaacucaccaagcuccuacagaccaagaauuacaacaucggggcugcucugaacacgauccaauauuc
gaugcacccuccaccauugugauagugcuguggccaagccccacccccuuugucuuguaguugcaucacguagagcagc
agggcuucuauagauaggcccagugucuuggcauucuuguagaaucuucaggugggaaugugugaugccuuuucagg
caauagguaugugcaugaggaaaguuuugaaugugcauaugcugacgccugagaucagacccagguacccauggcuaa
gcugagcuuccucugcuuccccuaggccuggccucuacagggaacugcagcacacacugcacucccaccuacucuugcc
gccagcauugcaccagcaguccagaauuccugccugacaacccguguuuccuuuauuaaaagugauuaguacaacugcu
aauuauuuucaacaaauaaagccauuauguuaaaaggaaacuguccauagugaguguaagguggcagacaagggccua
cagcuccuagaguauggaguauucauguguagccgaaugaaggaucuuaucuuauacugucccccuuucuaauggccac
ucuuuaguguuugugucuaauguuaaugcuuaaagcacaggacccccauguagcuuccucugacuugguuuguaagua
accugaauaaaaugccauaugcacuuuaacca
92 D26090 aaggggaauugcagaccccgucugggggaaacucccgccgccccgggguggcucagcucucugucucccuuaacccaggu
a
cagucauuucggucuucgacgacccgggcauuuucuacagcgacagcuucgguggcgaccccggugcggaagagggcc
a
ggcccgcaagucgcaacugcagaggcgauucaaggaguuccugagacaguaccga
a
ccuucaaguacagaggaugaacucaagcggcauuacaaccugaugaauacuggaucggagguaagauggaggaccuau
cc
auuuugacgaggaacuggcugaccacuugcauaaacagccggccgagcacuuacagcugcuugaggaagcugccaagg
a
gguggcagaugaggugacccggccccggccagcuggagaugagcugcuccaauacauccaggucaugcucaa
g
ccagcccgucgagcauucggauucugaagucagacaugaugucacaccuggugaagaucccuggcaucaucauuucagc
c
ucugcaguccgugccaaggcuacucguaucuccauucagugccgcagcugccacaacacccucaccaauauc
caggccuagagggcuaugccuucccaggaagugcaauagaucagucuggucgcccaaagugcccacuggauccauac
uucaucauaccugacaagugcaaggugugugggacuuccagacucugaaacugcaggagcugccugauacagucccucau
ggugagaugcccaggcacaugcagcuuuauugugacagguaccugugugacaagguuguuccugggaacagggucacc
aucaugggcauuuauuccaucaagaaguuuggcuugaaccccagcaagguccgggacaguguaggugugggcauccug
aacucguacauccaaguggcuggggcauccagguaacacagauggcucugggccggaaacuuuacugaucuggucagccca
caggaagaggaggaauuucgucgccuggcugcccuccccaacauauaugagcucaucuccaagagcauuucccccucca
ucuuugggggcauggauaugaagaaggccauugccugccugcuuuuuggggguucccggaagaggcucccagauggac
ucacucgccgaggugauaucaacuugcuaauguugggaaacccugguacaggccaaggucucagcucugaaguuuggugg
agaagugcucucccauugggguguacacaucugggaaagguagcagugcugcaggcuugacugccucagugauacggg
accccucaucucgaaacuucaucauggaagguggagccaugguucuggccgaugguggggugucuguauugaugagu
uuggacaagaugcgggaagaugaccguauugcaauccaugaggcuaugggagcagcagaccaucuccauuacuaaagcugg
ggaucacuaccaccuugaacucucgcugcucuguucuggcugcagccaacucaguguuuggccgaugggaugagacaa
aaggggaggacaauauugacuucaugccuaccaucuugucccgauuugauaugaucuucaucgucaaagaugagcacaa
ugaggagagguacaugaugcuagccaaacaugugaugacucuucaugugagugcacuuacacagacacagucuguuga
aggugagaucgaccuggccaagauaaaaaaguucauugccuacuaccaagcgagauguggaccucgggcuaucagcaga
ggcagcagagaagcugaagaaccgcuacaucaucaugcggaguggggcucgucagcaugagagggacagugaccggcg
uuccagcauccccaucacugugcggcagcuggaugcuauugugcgcauugcugaggcccucauuaagaugaaacuuca
acccuuuaccacugagggcugauguagagggaggcauuggagacuguuccagguauccacacuggauacugcuuugucugg
caaucugucggggguggagggcuucacuacccaggaggaccaggagaugcugagccgcauugagaagcaacucaagcgc
cguuuugccauuggcucucaugugucugaacacagcauuguccaggacuucaccaaacagaaauauccagagcacgcua
uccgaaagguacugcaggcucaugcuacgcaggggugagauccaacaccguauacaacgcaaggugcucuaucaccucaa
gugagcccauugcccaucaacccucaagccugaaaugcugccaccacccuaucucccagucagugcuccaaaccuccuuu
ugcccugccucuccaccucagacugcugucugcagcacaucugcagccccuggaaauguacuuuguucuguuggcuca
uacuguguuugaguaucuggaggacucucuacucuggguggucuauccccugucaugccuucucaacaagaugagucugg
agcaggaacaggcccuggaauguagaugggucuguauauuggcucccgggccacucacugccaagcuucuuuguaugu
acacgguaauaaagcaauuggucccuggcugcuaaggucaguagacccagu
93 A1787627 ggaugcagccgggaaggugcagcggugcguacgguuuggugauucgcuguggugcgcuccgcau
gugcagccgcgugggccauggggcggcgggcgcggggccggcgguuccagcagccgccgc
agccuuagggcgaugaagacgccagcgacggcggcagaaaucgaggccagucgggcuggg
aagguagcuaucccggagaucguaaaggagaacaagcucuucgaacacuacuaucaggaac
ucaagaucgugccagagggagaaugggaccaauucauggagucacuccgagaaccucucc
cagccacacugagaaucacuggguacaaaagccaugccaaauagauucuccauugcuuga
agaacaaguacuuuaaggagguuggaaganccuaaaauagauggacagaaaguugaguucc
acaaccacuaagcugguacccugaagaacu
94 M33988 gagcucaaauucuggcuuucuauugaggacgauauauuaaccaaugggagaaacacaaac
agaauaccuccaguuaguauaaaugcuugcuguucaguugcagaauuuacuauauauucu
uuuccuuucucugcuuugccuuuacugauacuuaaacgcauacaugucuggacgcggaaa
gcaagggugcaaggcccgcgcuaaggccaagacccgcuccucccgggccggccugcaguu
ccccgugggccgcgugcaccggcugcuccgcaagggcaacuacucggagcgcgugggcgc
cggcgccccgguguaccuggcggcugugcuggaguaccugacggccgagauccuggagcu
ggcggggcaauggcggcccgcgacaacaagaagacgcggcaucaucccgcaccaccugcagcu
ggccauccgcaacgacgaggagcucaacaagcugcugggccgcgugaccaucgcgcaggg
cggcguccugcccaacauccaggccgugcugcugcccaagaagaccgagagccaccacaa
ggccaaggggaaguaaucuggcgauugucuguacugcccaguugaaaguuaaccaaaaca
aaggcucuuuucagagccacccacaucuuuccauaaaaugagcugccaccucgugaaacg
uucuuccacuacaguuuuuauacuacauaugaaaaaguuacgaaguagcuuucaaucuua
guaaauugauuuuaauacuguuagucccugcgauaaaucuuacgaccuuccuuaguuuga
gucaaaagugugguaaaagaugaaaccuuuagaacauacuauaaauuuggaauagaaauuu
ggcacccagguuugucauucacgucacgauugucuagagcauaaugguaguaagggcuaa
gggccauuaaaucccacuuccauaguuuc
95 A1845182 uuuuuuuuguuugguuggaaaugaagguaauuuauugaaacugguuuugggacaggcga
guggacaacuguugaaaggagcuagcgcacagccgggugggagcggguucuuagccacag
auccuaucuaaggcccaacuuuuucuuuuccuucugcuucuuacgggaccacauccagguu
ccgguccuuccacaugcuuuugcgaagcuugauggggcgugagcccacauacuucccauu
caucucucgcauggcgcgcacauagucacuggggucuuuuuuaagcugacaaagccauagcc
cuuggguuuugccugugcggcuuguca
96 AA619207 uucugauccuugccaauauauguaucccauuuggaauugugaucuuaaaaugugaguuca
uggcauacuaucuuauuuaagauacuugcaccccacccacucccaucucccaaaacugggaa
cacugccaacuagguccuuaagaaucacgcaauuaacacaagguugggugcugcuaauuc
uucaugaaaauccaaacacguuaagguaccagggauaugccacugccccccugaauuuuc
aucaaaaauagacacguuuauguaaacagaacuauuuccauauucauaggugacuuuuua
aguauuugagccuaaagauuuugaucuccauuuuuauaacuauuuaaauuguucacaauu
auuacau
97 AW125783 cggccgccgccgcccccacacugccccgcguugacgagcgccgcgacggcaaggacagcg
ccucgcuuuucuugguggcucugauccuagagaccucaaccagcaggcgccggcgcccg
cccccgcggaacgcagagaagggggccacugcgcggcaaggcgagggacccccuggccaccugc
cgccugcgcccccugcgccgccacccggcccagagcccgccuccccgggacaagcaggcg
cgccggccgcgccccccagccccgcuuggaugagccggaggcgucauuggaucaggagc
ccggccccgcaggaggcggcgagccuagccucagacaaagagucaggaauccggaggcc
gcgcggaccucgaguccccgcagaggaagcacaagugccacuacgcgggcugcgagaa
98 J04103 Sequence below.
cgucagucccuccaccuccccggccccgcgcgcccggaucggcccuacggccucgucucgcccugccuugcgcgccgguac
cgccgcgaucuccucuccccgccgcccuccggcuggcccugccugcugcggcgcgaugaaugacuuuggaaucaagaacau
ggaccaaguggccccugucgccaacaguuuucgugggacacucaagcgccagccagccuuugacaccuucgauggcucucu
guuugcugugcucccuucucucagugaagaucagacacuccaagaagugcccauggccuggauucugucucccauuacuc
ggccagcuacgagcuGGccuuugcucacucccugcagcaagggcaggugauaagccaagccuuaaaagccaccuucaguggcuu
ccaaaaggagcaacgacgucuuggcauccccaaaaaccccuggcuguggagcgagcagcaggugugccaguggcuucucug
ggccaccaacgaguucagccuggugaaugugaaccugcaccaguuuggcugaacggccagaugcuguguaaccucggcaa
ggagcGGcuuccuauagcuggcaccugacuuuguaggugacauccucuaugaacaucuagaacaaaugaucaaagaaaacca
agaaaagacagaagaccaauaugaggaaaacucucaccucaacgcgguuccucauuggaucaacagcaauacauuaggcuuc
agcauggaacaggcuccauauggaaugcaggcaccaaacuaccccaaagacaaucuccuggacagcaugugcccgccaucgg
ccacgccugcagcucuaggcucugagcuccagauguugcccaaGGucucggcucaacaccgucaaugucaauuacuguucca
ucagccaggacuuccccagcagcaacgugaauuugcucaacaacaauucuggaaaacccaaggaccacgacucuccagagaa
cgguggggacagcuucgagagcuccgacucgcugcugagguccuggaacagccagucgucccuacuggauguacagcggg
uaccuuccuucaugagcuuugaaaggacugguagccagucucuguaccucaguaagcuaaccauguccuucaaagacuaca
uccaagagaggagcgacccagucgagcaaggcaaaccaguuauuccugcagcaguacuggcuggcuucacuggaagcggac
caauccaguuguggcaguuucuucuggagcuacucucugacaaguccugucaaucuuucaucagcuggacgggggaugga
ugugaguucaagcuugcugaccccgaugagguugccuccggugggguaagaggaaaaauaaaccaaagaugaacuacgag
aagcugagccggggcuuacguuacuacuacgacaagaacaucauccacaagacuucgggcaagcgcuacguguaccguuuc
guaugugaccugcagaacuugcugggcuucacuccggaggaacugcaugccauccugggcguccagccugauacagaagac
ugagggccuca
99 D90146 Sequence below.
auggcucuaacaacggcugcucuuggugguagcgggccggcccugacccugaucggagacccgcgcgauugaggugcgaugucggg
gagggaaacagccccugugccgcguccccgcuucgcccaccggaccuccgccccuucuccacccgagccccgagcccugcuc
cacucccggcccgcguacccuaccggggucccgggaggaggucugggucucaccgcgcgccgcccccaggcccacacucgc
ugcggguauuuccacaccgcugugucccagcccuacucgggggagccccgguucaucaucgucggcuacguggacgacacgc
aguucgugcgcuucgacagagacgcggaaaauccgaggauggagccgcgggcgcgguggauggagcaggaggggccggag
uauugggagcgggagacacagaucgccaagggccaugagcagaguuuccaagggagccugaggacugcacagagcuacuac
aaccagaacaagggcggugagugaccccgggucggaauucacuaccucuccacgucccgaaacaggaggccuugaggguccc
gggugcaaaguccgagguucaggagcagaacugacccaggacuggauucccuuucaguuuggaggaguccgcgguggggg
ggugggggggggcggaggagggacugaccacugggucccgcaggcucucacacacuccaguggauguauggcugugaca
ugggguccuauggcgccuccuccgcgguuaccugcaguucgccuaugaaggccgcgauuacaucgcccugaacgaagacc
ugaaaacguggacggcggcggacauauaggcacagaucacccgacggcaaguggaugcaggcugguauugcagagaggagacc
gggccuaccuggaggucgcgugaggcuccgcagauaccugcagcucgggaaggagacgcugcugcgcacaggugcagggg
ccgcggucagcuccucccucuucccucaggcuggggcucaguccuggggaagaagaaacccucagcugggguguugccccu
ggcucagaagggaaagagugacccuggggucuccugaucccucaucacaaugacugcacugacucucccagaucucagccuu
cucccuggacagugcccaggcugucucaggagggaaggagagaauuucccugagguaacaacagcugcucccuucaguucc
ccuguagccucugucagccauggccucucccaggccaggguucucagccuacacccacugucuguauacacugacuccugu
ccugcugaaugugucagcccuuacaccucauaaccugaagucuccuuuacccgaugggagacauggacaucuacacuaauc
ugguucccccaguuucuagaacuuuccaaagaauacagucuaccagauccuucccugucugugggguuugcauccuuugac
acccaauucuaucuauuccugcaauggugaauagucacaugagccauuauggguuacccuaaacaaauacuuuucuugugu
uuuuccccucucguuuucuuuuuaucuuuacuuuuuuuuuaaggGGuauuauguuacuuauaaucaggguggucuucggca
cuggaaugauauugcucucucuccccaccauacccccacccccgccuauaucauuuguaucaguagcccuggcugucgugg
aacucacucuguagaccaggcuggccuugaacucagaaaucagccugccucugucucugccucugccucccaagugcuggg
auuggaggcuuggaccaccaccacugagcagaagaaagguuccugugagcuuaaaauguuuucuggcagaauuaaccaucc
agaucacuccugauaucccugugccccaccaaguuacagugcucccccuggugaaucagaacuuggacucugagagacagg
guuucugcaauccaggccugagugagagggaagaccacacacccuggagcccacuguguuccagugagugcugcacugg
gguccacagcacauuccagggauccugugugacacaucuguaccuugucccccagagucaggugcugggagucauuuucuc
ucagcaagaugaccacagugguuuagucucaauggugucacucuuccaguagcauaugguccugauuucuaauuuagaua
cgaacucaaacacauaugaaauuucuuauuuuccauuccaucuuccauuauauagcuaccuaucucgugcuauugaacauc
acauaaggaugaccauguugacccacuagcucauguggauucccucuuagcuucugaauccccucaggaaaaugugcaguc
cugugcugagggggccagcucugccugaggucacuagugccaugacaguuaaaguguucauacagacacauaguucauu
guaauuacugauuuagcguugucuugucauuuuucaguuugcaugcauuuauuuauuuauuuauuuauuugguugguua
uuggaugcauggaaauacacuguugcuguacugaugguuggggugccuuugugugguuguugggaaauugaauuuuuuuu
uuuaggaccucucuuugcucuggucgacccugcucacuccggucaacuccuaugggucaacucugcucauucagucccugc
uuuuucuggcccaaauauuuauuugguuauuuauuauacauaaauacacuguagcugacuucagaugcaccagaugagggcg
ucagaucucauuacaaaugguugugagccaccaugugguugcugaaguuugaacucaggaccuucaaaaaagcagucagu
gcucuuacccucugagccaucuccccaguccucaguuugucuucuuaauugugcgauuucuugaaucuuccaaacagaucc
cccaaagacacaugugacccaucaccccauaucuuaugaugcugucacccugaggugcugggcccugggcuucuacccugu
ugacaucacccugacuuggcaguugaauggggaggagcuaacccaggacacggagcuuguggagaccaggccugcaggga
auggaaccuuccagaagugggcagcugugauggugccuuuuggggaggagcagaauuacacaugccaugugcaccaugag
gggcugccugagccccucacccugagaugggguaaggagggugugggugcagagcuguggucagggaaagcuggagcauu
cugcagacucugagcuggucagggcugaugcugggaucaugacccucaccuucauuuccuuuaccuguccuucccagagc
cuccuccauacacugucuccaacauggcgaccauugcuauugugguugaccuuggagcuguggccaucauuggagcugug
guggcuuuugugaugaauaggaggugaaacacagguaggaaagggcagggucugaguucucucucagucuccuuuagaag
ugugcucuaaucauuaaugggaaacccaucuacaccccacauugcuaccuucuccaacuggguccucugucaguucuggga
acuuccaagaucuuccuugaacucucacagcuuuccuucucacaaguggacaaggaggggacuaugcuccagcuccagguu
agguggggacaggauuguccuguggacauugcagugaagcuggagauguuggggagcucugggaacccauaguauucu
uccagagaaaucuuccagggccgcaguuguccaauaugaauacauauauguacauaugcauauacauuuuuuacccuuggc
aaggacagcuccuagagcucuaauagaucucucccaagugguaaaggugacacucugggaccugauuggggaggggcaau
guggauaugauuggguuucagggacuccacgaauccccucugagugagugguggguuguuggaauguugucuucacagu
gaugggucuugucccuc
100 AI563854 uuaaaucuggagggauuuuuucacacagccuaucuuuuuaggugugccuuucccauauuuu
auuuuuacucgaguuguuguuuuaaaaaaacagcagcauuaucaaagacacaucuguacaa
acauuuuuacaaaagagaacucucuaggaucagcuacaucaaguacaaucagnaaaauaua
ugcaguccaacaaagacauuuuuaaaaugacuu
101 AF017128 Sequence below.
ggucgcuuucugucuguagaggcggcuugccacccgagcagagggucgugaaguuccgaccggaccgguccacagaggu
ucaucugaagagguggguccccuccgaggugaaaggcgccgcugagaaacgcccccaccccccgugguucaaguauauca
gcccaagaacuuuucauucauaaaaaagaccagacuccgagaggcgcgagugagucagaaccgcagccgccaacgcggacc
cuaccgaacauccagcccagggcauguaccgagacuacggggaaccgggaccgagcuccggggcuggcagcccguacggu
cgccccgcgcagcccccgcaagcucaggcacagaccgcccagcagcagguaagacuggccaaaucgucgggggagggggg
accugaguuuggacagcaucagggaugcugggauuagucuaguuugcuccgggauuuggacuggggccccgagcagcau
cugacucugguggucgcgaccgaggauccugcacguucuguguggucggggaaccuauguacccgguggccaaggggac
gagcgcagcgggaagacgauuaucuucgauuuccccuucucgcucgcccguaucucccuagcuuacugucuuucuuccc
cuccgucuccguuugcuuacauuuccuccuaucugccccuaauacgcugucccucuaaauaccugccccaucccugc
cuggacaauaucagagguguucuccaucuccaguuaauaacugggaccuggggucugggcacauagaggacaggguccau
cagaacucagccgggacagagaauucuuagcagccuguccgaggcuguccguguguugcucugguuguuccgugucccuu
uauccggucaaguccucaucucuuugugcgcaguauagagcccaugggccccaggcagugguuccgagggguuccugga
gaccacgauguguugugaugugcgcggggucaccuucccggccacacucgcgcuccacauucucggcacccgacgucucu
cacugcuggauaggggcacuugagagguugcagguguccauuuccugucgaggggccgcgagcacgugucgccagggga
gggaaggagcugcguccguuucgccgagucacagcgggccgagucacugaggcugagucacccuggggccccucccuu
ccuggccccaaacggccccuaaguaccgacgaccugggagcgagagaugccccuggcauugcuucuagcccagaucggug
aucacuGGagaugcuaggucccccaguauugggcuggggacauaggcuguccagacuugccuaagcauaugaauugcuucc
uggacuggagggcccccacauccuuagcucacagagcuugaacccaguuuucucucccagaacgcugagcccccaccccca
ccgacacucaaucccaacacaugccuucagauuucugcaagaaaaggaaguaaaggaugccagaccccuuauaggaggcuuu
uacucucuucacuuuauuucauggacuuaaaaaaccccaucaauuuaaacuuucaaguuuuuaaucgacagcuaggca
ugcauuuaaucccagcauucaggaggcagaggcaggcagaucucugggaguuugaagccaauuuggucuacaaagugac
uuccaggucagcuagagcuacauaauagagauccugucucaaaacuuaaaaaauaaaaaacaaaaacaaaagccgauuaaa
acucugauuucugaacuaugaggagcuggcuucucaacagcaaugaaacguuggaaugaugguuaauaacagggaaacugag
acuaaauaacaugccccagucucaaagcccaucaauggccaagcuccaagcugaugcuggacucccaagcucuggugcuac
augucuauagucuuggugccugugagguagaggcagaggaaucgugaguuuaggucuagccugagcuaugugagaucc
caccccacccccgggcccccaaacaacaaauucucauccuaauucucagaauugccuuaggaggcuagaagcuggaaagu
augcccaucuugugaggacugggucucaaaucuuuaguuucuacuuacuuagcuguggguucuaugggcaacugcucuuccugu
cugaaaacaggauuauggcagcugugugagucacuauuuguuaaauaguuggaacaguguuacgcaguccauacuugau
uuaaaacaaaaaaccaaacuaucuucuggaggguaaacagacauacgaagagagacauuuugugaccugcccaaaaucacac
agcuccugaacaaguaaguuucugguugccaaauguugcuuccuugugguucucccaaaacugguaucuuacacuugagguuga
agggagacagaaguccagccucuguccccgggaagccccucaguccacacagaccuuaucauuucccuucuuaucucuca
gaaguuuccaccuugugccaagcaucgacagcagcagccaggaacugcacuggauggugcagccucauuuccugguaccca
cuggcuauccccgaccucugGGccuauccccaauacagucccccucagccccggccaauagucauacggagcccuaggggccac
cuccgggggugcgucgcaggcccugcgagcagguaagaaacagcgauguuucacuuuccauagcccguagggguccuac
uagacagggacaggaucuucuacgauggaauaucuuauucagcauugaaguuccuuagaggccaagaaggagguaaaa
ggucaccuuugaggucaaggaagggcauccugggagaaggcuacacguaaccuaaaccacgggauaggauuugcauauauaa
gcugaaaagaaucuucugggaggaggguuggaggcacagauugaggugaaggggacagaguguuaagugagcaugucu
ccacugucuuacgugcacaggguugaaggaagccugaugcuugcuuuguaccucggggugacucuucuuuucaacaguc
acggaaucucagccuauuucuuuuaauuaucacaaaaagagugggcaguggguggcucacaccuuaaauuucagcacug
gggaggcagaggcagguggaucuucuggguucaaggccagccugguguuacagagugaguuccaggacagccaaggcuaca
gagaaacccugucucaagaaagggaaaaaaaaagugaaugggaauguauuucauuuuuccaucuuccaucagaggaag
ugaagcauagaaggguacucacuuguccagauucauacaaauguggaguaaugagacaauacugguccugggccugaggguc
uacucaacucccaaagucagagcuuaaugagccacugucucaaugggagcucacagaagccugcagagggagugagcuga
gaacuuuugccucccugaugccuuucuaaaauaaagaaggguguguuuugguugguuuguagaguuuggggucuugag
agccuccugccuucccauuugcuaggaguauagguguauucuagauacccgacagggaugacggaucuuuuaggccaua
gcacuuucuuuccuucucccugaaguacugagacugagucuagugcagggaggccuccauacuaaaaagcuggguguaccc
guaaucccagaacucggaaaaucaagacaggaggagccauucaagucacgcucagaaacauggagaguuuaaggucagcc
ugugauauauaaacccuaucuccuauaaccaaacaacaaucaaagcaaaccugacuuaauuguuaaguaggaaauaauaug
cuguaaggucaucagccuggcugggggacuaaccgccucugaaugacugaagaaccugcuucaaggcccggagcccugcacu
caaccccuaguggaugcacacacagauccuugccaugauggcucgaagagggauggcaagacccugggagauaugugaga
uuugccagagaagagccagcaacagucuucccagcaagggaacagcuuaccucugugaucagcuggggcgugagcaagag
acaagcccaggGGugaauccuuccuuuagcccuauccugaauagacaccuuuugaccacggguacuagaggguuggaggcu
gugagcuguggguagguggcuuccccucggugugcucuggaacuugaacaaaucacucauccuuccugagcuuccucac
augugaaugugcagagaucuggaugggugacucagcagcaucucuggcugcuccuuagaggauccagguuccaaucuca
gcacccacguggcaacuucacuguccacaacgucccccaaagguucugaugcccucuucuggccuccaccagcacugaaugc
acaaggugcucauacaaacacacaggcaaaauacucagagguaaauuuguucuuuuuuucuuuugagacaggguuucu
cuguauagcccuggcuguccuauaacucacucuacagaccaggcuugccucaaacucacagaggcaucugccugccuccc
aaguguugggaccaaagauguaugccaucacuauaagccuuuuuuuuuuuuguaaauuuuauuuaugaaugagugcuuc
cauguauaccuucaugccaggagagggcaucagauccuauuauaggugguugugagccaccguguguggcugggauuug
auucaggaccucugaaauaggagcucuuaacugcuaaaacaucucucuagccccagucuacauuuuuaaaucuuuuuu
uaagauuaauuuauuuauuauacauaaguacauuguagcugucuucaaacacuccagaagagggcgucagaucuuguua
uggaugauugugagccaccaugugguugcugggauuugaacucaggaccuuuggaagaguagucaaugcucuuacccgc
ugagccaucucaccauccccuuuuuuaucuauaaaaaaaaagggguggggccuggagauauggcucagccguuaauag
cacugaaugcuuuuccagaauuccugaauucaauucccaacaaccacaugguaacucacaaccaucuguaauggggaucca
augcccucuucugguguaucugaagacagcaagggucuacucacauauguuaaauaaauaaauaaaaauuuaaaagccag
guuguguugguucagacagcagaucucuguuuaaggccagccuggucugaucuacaaaccaaguuccaggacagccagg
acuacacagagaaacccucuaaaaaaccaaucuauguaggggguggcuggugaaaugggcuccgugaguaaaggguacuugcu
gcgaaauuaaugaccugaguucaauccuugaaauccacacaguagaaggagagaaccaaccuccaagggugcuaugacaca
cacacacacacacacacacacacacacacacacacacacacacacacgacuauauauaugaauauaugcucuagccaggca
uaguggcacaugccuuuaaucacagguacuugggaggcagaagcaggugaaguuugaauccagccuacagaguaaauu
ccaugacagcuagaacuaugaagaugaacccugucuuuaaaaacaacagcaacauaaagaaucuauguagggaagcuggaa
gggaugcugauacagucugcaauccuauuacucuagagguggaagccaaagaaucaggggguuucaggccggucuugccu
uacacugagcuuaggccagccugggacacaugagacuuugucucuuuuuaaagacaaaacaaggggguugguuagau
ggcucaguggguaagagcacccaacugcucuucugcagguccgaaguucaaaucccagcaaccacaugguggcucacaac
caucuguaacgaaaucugagucccucuucuuugagugucugaaaacaacuacaguguacuuacauauaauaaaaauaaaua
aaucuuaaaaaaaaaaaaaaaagacaaaacaagccagaugaggucugugaguuccaggccagccuugucuauaaaucaagu
ucaaagccagggcaggggcuacucaggagauucuaucuaaaauacaaagaaacaaaacuacaaaaagcaggaaaaaggaaucuac
gaaagggcuggugaagggguguaacucagugguagagcauuuccgaguagcauguaccaagccauggguuugauccc
uagcacuaagcaaaagaaaaguccuacaaagggcuauguuggcauauuagauugauucccaguaucuuuuggcacucaag
aacaccuucuacaauucacaggcuccuggaugaagaaaucccaucuuccacaaaugaggaagcuggagaguccugugaaaag
agauaaucaugucucauacacucaggagagaaggcuacuucugccugagaaaugaaaaggcuuccuggggucccaacauc
uuaguccaguccuaagaugcggaagggaggaagaucaaauuuacauagagggauucauucaggaaauaaaccaucag
uaaagcuagguguaugugagcuauaaaugucaccaauggagaugacaagcgguccaguacaggagaagcaacuguauaguggu
cauugucucccuucuucuaucccaaccuagaucagcccagaggggaagagcgccgcagggugagacgcgagcggaacaa
gcuagcagcugcuaagugcagaaaccaaaaaaaggagcuaacagacuuccuacaagcgggugagcaucauccccaggccca
gacccacagagccccaagaggggucucggcucccaagaacacaaaagacccaaauuuacuuccuucaggacucugucauccuc
ccugccugugguugaaguccuggaaaaaggauaagggaaaguggcuuaaauauuguuugucgaucuucgaguucagagucg
aagaugguaggcagcaauucuccuaagaugccccuucugaugggagucauggccauuuucucccagaggcucacggga
gggagugcaguccagacuuguuggggaugacaggcacaguucccuacuccagccugaggcuuggggaucuuuagccuuc
auuuuccuaucuuucugcuaauccuguaaagugaccgacaaauuggaggaugagaaaucggggcucagcgagagauu
gaagagcugcagaagcagaaggaauccuugagcugguucuguaaucccaucgccccaucugcaaaaucccagaaggaua
caagaaggacccaagugguucuggcaggcaccagcauugcuagcagcccaccaGGcccccggccgcccaguggccuugcaucu
cccuuucuccaggacccguacuugaaccggaagcacugcauacccccacgcucaugaccacacccucucugacuccuuua
cuccgagucugguuucaccuauccuagcacaccauaaccuugcuccuccucucaccgaaagaguagcagcagcaguguc
aaccccuccuccgacccccuggGGcucuccuacacuccuggcuuugugaggcacccagccacaucccuugcugguggcuacu
ccaagccauccccuuucucccauugauccagcaggccuggaccauacccuugccccaaaccagcagaucuuuuaucucuuc
caacuagaacaaacacauuaugcuuugaugguagagccaggcuugaaggauauccccaaaggcugcucacugguuuuucuaggug
cuggccuaucauaauugcacaaaauuagaggaaaauauguucccucugccagagaacgccuggcagcccagacuuugua
gauccccagggguccuuugacacccuuaccccuugcagaccacuuucccacaccacgucacuuucuucauguuauccagc
cuacucuacaccuagacagaaggugcccuuugacuagccuagaacacuaacucacacagcaucaacagccagcagcaccgg
acauccugcaggcuccuccugaauggcacaacgcaggaggcgccaggggcuucugugaggagcggagcugcacucccuag
cucugagaagcgcuuagcuucaggguauccgagccuccaccgcaagggcagcugcuauuuauuuuccuaaagagacuauuuuau
acaaaccuuccaaaauggaauaaaaggcuug
102 X67644 Sequence below.
ccauggguuccuaauggugcuauuaacangggcacaaagucucauaauuuuagaaacuucacuuauuuugugacccaccu
aguauggggcaaaggcaggagcuucggacuuccugucuucccuuaucccuuugaauagcgucucgggagugucccuaag
uaaccauugcaguuuuguguccguuugcucuguunaaucucugugauguguguaugguuuucacgugaacggaggcag
acagagcccggucuguggGGuucuagugugguucuuuaucuucuuggaaguuugugcaauaacuucccuccugguuuccugc
gcauaccuccaaguaaguacgugaauguguuuucuguggucccuugaucuugcuggacuucacuaaggaggguggcugga
ccaucugcuacgugucugagagccccucucuagcuaccucauguccggacgugagcuuacucccaauguuuuacccacaa
acauucacuacucccaauaaagaacaugcacuauggcaccuaGGugaauaaccaaucaacgcuccgccuacauuugcuuccu
ccuuggaauuuccagccccuugcagccaacugcuccccagcugcgaagggcggaguuccccccggcccggccccuucuuug
gcucuauaaguagcucugcuuugcgggggauuugcacuccucuacacucucugcacaacgucuaaauuaugugccacucgc
gcaaccaucuccacaccaugacuggccugagggccccuucuccagcucccuccaccggcccggaacuccggcggggcucugg
ucccgaaauuuucaccuucgacccucucccggagcgggccgugguguccaccgcgcguuugaacacuucucgcgggcaccg
aaaacgcagccgaagggugcucuacccucgaguggugaguaucgcccgagugggcaucaggaggucgcgucgcccuggaac
uuguagguaacaacuaggagcagggaccuucgaucugacguuucccucuuuuaucugcucagguccggcgccagcuaccaa
ccgaggaacccaacauugccaagaggguccucuuucuccuguucgccaucaucuucugccaaauuuugauagcugguaggugg
gugugucgcagccccuggcuccggaggaugcuaccagcgccgugacaccugagcccauuucugcgcccauuacugcgcccc
cgguccucgagccuuugaaccugaccucggaguccucggacuaugcgcuggaucuuaaagcuuuucucuagcaacauccgg
cagccuucuaaacggcgaugggucacaguccgguagguaacaaaggcaccauagauauguaccuagugcaagagaacguauccc
aaacugggauuucuaaggcaacgcuaacucagaacacuaccgccaagagacaccgcggguccuggcuaggcccacuggggac
ggacagagacuuucuccgugucuaauuaauauuuauguauuuauguauauccuccuaggugaaggagggguguauguaau
auuuuucuaacuuauacagggguggcgaaauaugccucccugcugguaacacaggauauuuauuacgauuuauagggucggu
aagacagaguugugggagggaggacccgggugguaggacucccagcuuggggauuagucugggggggguguaauaagau
uagguguaacacuccgucuuccagcacuucaacucuguagucuguuguaaggcuuugaagacccuugggaauccggccu
uuggaugucuucugguugcuucucaggggcagcugcaggagucuuggguccauggauugucagagggcggcuaucuaugg
ucgccuaguauguauguucugugaacacgaauaaacuugauuugccugucauuauuaucugcaguucucgaaguguauca
uucag
103 AF064088 See above (same Accession Number).
104 AI843085 uuuuuuuuuuuuuuuuuaaauugccgaauuaaguucuuuuaauagauugcauauauaga
u
guuuagccauacucuagaucaacucuuuaagaguagaauuuuauauccaauuuacaugcu
ucagauaucaccucuguuuguuacauaaggucuuguauccaaauguccacuuguacacug
agagcuuuaggaacaaaaaaggacacagagagaguugccauuuuuagcagcaaugaaaca
ucacuaaccccuuuuuacauaccgaauucaagucacuac
105 A1843085 cggccgccgguauuuuuungcaaguauugagaguucuguauguuuugaaaagaguaauuu
uaacguuugggugccaagaaguggguuuucucagaguccauugccggcaaugggcaagcc
uggcgguacuccucgugccgaau
augg
106 X58609 cgcugggaacgcugcuccugcugcuggcggccgcccuguccggacccagaaccgagcu
gugagugcagggucgggagggaaacagaacuuuccaaacagucugcggagaggagcggau
gcggcaccggggaagccgcgugcccgcgucgcccaccagacccuccgucucuuuacccgc
gucccuagccccgcgcccugcuccccuccugucccgcgcauccgccugggucccgggag
aaggucagggucucaccgcgcgccgcccccaggcucacacucgaugcgguauuucgagac
cgucgugucccggccgggccucggggagccccgguacgucucugucggcuacguggacga
cacggaguucgugcgcuucgacagcgacgcggagaaaccgagguaugagccgcgggcgcg
guggauggagcaggaggggccggaguauugggagcggaucacgcagaucgccaagggcca
ugagcagugguuccgagugagccugaggaaacugcuaggcuacuacaaccagagcgcggg
cggugagugaccccgggucggaggucaggccccuccacuucccgacacagggacgcugac
guccugguucccaagucugagauugagaacagaacggacccgagaccgguuucccuuuc
aguuuggaggaguccgcgggugggcggggcugaccgcggggucccgcagguucucacaca
cuccaggagauguauggcugugaugugggaucggacgggcgccuccuccgcggguaccgg
caguccgccuaugauggcugcgauuacauugcccugaacgaagaccugaaaaccuggacu
gcgaaggauguggcagcgcugaucaccagacgcaagugggagcaggauggugcugcagag
uauuacaaggcuuacauggagggcgagugcgugcagucgcuccgcagauaccuggagcuc
gggaaggagacgcugcugcgcacag
107 M18837 Sequence below.
auggcgucaacaaugcugcuucugcugguggcagucgcccagacccugaucgagauccgcgcgggugaguaccggguccg
gagggaaauuggccucugaggaaaggggagggggcggcacgggggaagccugucccggcgucgcccaccugacccuccgcc
ccuucuccacccuagccccgcgcccuacuccccucccggcccgcucacccgcgggggucccggaaggaguucggggucuca
ccgcgcccugccuccaggcccacacuugcugaguuauuucuacaccuccgugucccggccgggccuuggggagccccgguu
caucucugucgguuacguggacaacacggaguucgugcgcuucgacagcgacuggagaaucgagauaugagccgcgggc
accguggauggagcaggaggggccggaguauugggagcgggaaacacagaaagccaagggcaaugagcagauuuuccgag
ugaaccugaggacccugcucagcuacuacaaccagagcgcgggcggugagugaccccggaucggaggucacgaccccucca
cgucccaaaacaggguccgagacgucccgggccccaaguucgagguucugagcagaacggacgcgggacugguuucccuu
ucaguuuggaggagccgcgggugggcggggccggggcgugugggcggggcugaccuggggucccgcaggcucucacac
uauucagaugaucucuggcugugaaguggaguccgacgggcgccuccuccuggguaccagcaguucgccuacgacggcc
gcgauuacaucgcccugaacgaagaccugaaaacguggacggcggcggacauggcggcacagaucacccgacgcaaguggg
agcaggcuggugcuacagagaaaagcaaggccuaccuggagggcgcgugcgugcagucccuccgcagauaccuggagcucg
agaaggagacacugcugcgcacaggugcagggaccgcggacaacuccucccucuacccucgggcuggggcucaguccugg
ggaagaagaaacccucagcuggggugaugccccugucucagagggagagagugacccuggucuccugaucccucaucacag
ugacugcacugacucucccagggcucagccuucuccuggacagugcccaggcugucucaggagggaaggagagaauuucc
cugagguaacaacagcugcucccuucaguuccccuguagccucugucagccauggccucucccaggccggauuucaaccc
acugucuuguagacacugacuccuguccugcugagugugucagcccuuacaccucaggaccagaagucgccuuuaacugauc
ggagacauggacuacccuacacuaggcugauugccucaguuuccugaauuuucaaaagaauacauuucccagaucccucc
cugucugugagguuuuccaccccuucgacaaccuaauucucucuauuccuauaguaguggucacaucagcccuuauggggu
acccuggaggaauaucaauaguggaauuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuu
cuuucuucuuuucuuucuucuucuucuuucuucuucuucuuccuucucucucucucucucucucucucucucucucucucuc
ucucucucucucucucucucucucucuucuucaguuuuuugagauaggguuucucuguaugcccuagcuguccuggaacuc
acuuguagaccaggauggccucgaccucagaaauccgccugccucugccucccagugcugggauuuaaggcguguggccac
cuugcccagccuuucuuuuuucuuuacuuuuuuuuuuuuuuuuuggagguauaauuuguuucuagucaucuuuguc
uuuugucugcacuggagugauccuguuucucccugcccuuauauuaucauguguaucagucuccacaggugccagggaag
uuaagacaaguuaaaucaggguucucuuuaaaggagagauuccugugaacuuagacuguuuccugucagaacuaaacaucc
agaagccuccugucuuccucugucccacauguuacagugcuccccccccccccccagugaaucuggacuuggacucugau
gacagggucuucugcaauccagggcuggagugagagggaagaccacacacccugugagcccacuguguugcagugagugc
ugcacugggguccacagcauacuccagggauccugugugacacaccuguaccuugucccccagagucaggggcuggaaguc
auuuuucuggcugagugucagagguuucaccauuucugcuacacacucugugauggcugcucacuuggacuggcgguu
augcuuauagcaagauaaacacaggugguuuacgucucaguuaucacacccuuccaguggcauauggcucuaauuucuacu
uuugauacgaacucaaacacuuauuaaauuaguuaguuuccauuccaucuuccauucuaguccauucaugcuaaagaacau
cacauuaggacugccaggaugacccacuggcucauguggauucccucuuagcuucugagucccccagaaaaauuugcauu
aaggaaaccagcucuaccugcaggucaccaaugccauaacaguuggaaugucaaacagacacauuauucagugucaucaggu
gauuuuacugugccuuguguagauuuagagggucuuguuuauugugguacuuuuuuuuguuuuuuguuuuuuuuuuu
uuuuguuuuuauuucaugacaggauuauucuguauauccuggcuguccuggaucucacauaguggaccaguuugaccac
aaacucauaaucuuccugccucuuccucccgagugcugggauuaaaggcguguaccaccaccaaccagcuaaucgugaga
uuucuuucuuuuuucuuuucuuuucuucuuuuuuuuuuuuuuuuuguuguuguuguuuuguuuuuugagacaggguu
cucuguguaucccuggcuguccuugaacucacuuuguagaccaggcuggccuugaacuuagaaauuugccugccucugcu
ccagaguacuuaauuaaaggcauguggccacuaccaaccagcuaauuguggggauuucuuaaaucuuccacacagauccucc
auaggcacaugugacaugucaccacagaucugacggugaugucacccugaggugcugggcccugggcuuuacccugcuaa
caucauccugaccuggcaguugaauggggaggagcugacccaggacauggagcuuguggagaccaggccuucaggggaug
gaaccuuccagaagugggcaucugugguggugccucuugggaaggagcagaauacacaugccaugugcaccuagagggg
cugccugagccccucacccugagaugggguaaggagggugugggugcagagcuggggucagggaaagcuggagccuuuug
cagacccugagcugcucagggcugagagcuggggucaugaccucaccuucauuuccuguaccuguccuucccagagccucc
uccauccacugucuccauauggcgaacguagcuguacugguuguccuuggagcuuggccaucauugcagcugugguggc
uuuugugaugaagagaaggaagacacacaaguaggaaaagggcaggaguugaauuucucucagccuccuuugaguguacu
cugcucaucaauggggaacacaggcacaccccacauugcuacugucuguaacugugucugcucucaguucugggaacuucc
uaguuucaagcuauuccuugaacucucacagcuuuccuuucacagguggacaaggaggggacuaugcucuggcuccagg
uuaguguggagggacaaaguuauccugaagucauggagugaagcuggaguuguuaggugcucuaggaacccauaauagc
uucucuguuguaauccucugguggccugugucagaucuugcuauagauauaucuuuguauauauuuuucccuaggcagg
gacagcucccagagcucugauauguuuucucaagauuguaaaggugacauucuuggccuguaugcagaggguacugu
ggacaugguuuuuuucauaacucccacaauccccuguggaguuuggguugguugggauauuaucuucauugugguagu
uccugacccucauucucuaucaugaagacagcugccuggaguggacuuagugacagccagugugaccuugggucuucauu
uuucuuuagagaacagcgccugauguucccugugagccuaugggcucaaugugaagaauuguggagcccagccuucgccu
acacaccaggaccuaucucugcauuacccugugguucccuuccaccgccaaccuuccgggucugcag
108 AW124268 uuuuuuuuuuuuuuuuucagaauaauugcagacaaauuccauuuauuuuucuaaaaacc
u
cauuucuaaaauuuauacaggccucacauuccuaaaccaccucuggcacuuucuugaau
unagucuaggcguacacagcuccgaaagaaaaauagagauccgguuccaggaagauggcc
augaggacucgcagauaugucuccucggaccuggaaugugucagccaugggauccacua
auccaccauccgguacacagggucacccacucucaucucccaaacuucuccaccgagaa
auacaucccaaaaaguggagaugacugguauauacucuucacagaaggaucacacaggcg
auagcucuucagggucuccagucgc
109 AF090738 Sequence below.
cucuagaugaauacacucucaugagggccaccuucucugguaguucaggucgccucugcccauccuucccugcguccucuc
ccaaagguggccuacaacccuuacccagaauacuaugaagacauugaaauuauucucacaagagguuccagcaguaaccuag
gggcagaugauggcuacaugcccaugaccccuggggcagcccuuaggagugguggucccaauagcugcaagagcgaugacu
acaugcccaugagccccacaagcgugucugcucccaagcagauccugcagccacgcuuggcagcggccuugcccccuuccgg
agcagccgugccagcacccccuucaggguugggcaggaccuucccaguaaacggagguggcuacaaagccagcuccccagc
ggagagcuccccagaagacaguggguacaugcgaaugugguguggcuccaagcugucuauggagaacccagacccuaagcu
acuccccaacggggacuaccucaacaugucccccagcgaggcaggcacugcagggaccccaccugacuucucagcagcuuug
cguggaggcagugaaggccucaaagucaucccgggccacuucuacagcucuuuccccgcucuuauaaggcucccuguucc
ugcagcauagacaaugaccaguauguggcucaugagcuccccuaugggccggaucuuggaagaagagagacuggagccccag
gccaccccaggggcuggcaccuuuggggcagcuggugguagucauacccagccucaucacucagcagugccuuccuccaug
aggccgagugccaucgguggccuccugagggcuuccugggccagcgaugucgggcaguucggccuacacgccuaucucu
agagggacugcagacccuucccagcauggcaagaauacccucuacccacagagcccaagagcccuggcgaguacaucaacauu
gacuuuggugaggcagguacccgucugucuccgccugcccccccacuacuggcauccgcggccucaucuucuucacugcuc
ucagcuaguaguccuucuucaucccuggguucaggaaccccaggcaccagcagcgacagccggcagcgcucuccacucucu
aacuauaugaaccuggacuucaauucucccaagucccccaagccuagcacccggcaauggggacacaguaaucuccauggau
ggccuucucucuccagaggcuucauccccauacccaccacugcccccacguccuuccacuuccccuuccuccuuacagcagc
cucugccaccugccccgggagaccuauaccgccugccuccagcaucagcugccacuucccagggucccacugcuggcuccuc
aauguccuccgaaccuggggauaaugguggacuauaccaagauggccuuuagugugggcugcaaccccaccacaaccuaucau
ggcaccuccaaagccagaaggugcccgaguggccagucccacaucgggcuugaagcggcuaagucucauggaucagguauc
ugggguggaggcuuuccuucaagucagccagcccccugacccccaccggggugcuaaggucauccgugcagacccacaggg
gggacgucgucuccacaguucagagaccuuuuccucuaccaccaccgucaccccaguuuccccauccuuugcccacaauucc
aagcgccacaauucggccucuguggaaaaugucucacucaggaaaagcagugaaggcagcaguacccugggaggaggugau
gagccgcccacauccccaggacaggcacagcccuugguggcugugcccccagugccacaggcuaggccguggaaccccggu
cagcccggagcuuugauuggcuguccuggaggcagcaguucucccaugcgcagagagaccuccuuggguuuccagaacug
ccucaacuauaucgccaucgaugugaaaggcgaacaaggguccuuagcgcagucucagccgcagccaggaggacaaggaacuc
cuggagccggacccguagccuuggggggcuccucggcaccgucggaggcucuggcgccagcggaguguguggggguccag
gcacuguagcuuugcccucugccagcaccuaugcaagcaucgacuuccugucccaucacuugaaggaagccacagucuuga
aagguggaggcccuuugaccuugaagauaugggagggaaaguauaguauugggguggcu
110 AI834950 uuuuuuuuuuuuuuucagcugugaacuauuggauuugagacaggaacagaacaaaucg
acgguuccagaggaguuguggagagagcacgaguguuuuuaaauaggggaggaugggagcaug
gcggugggggugggggaagaguuauuuacaagaaggcucagggggccagaggcucaucuu
ggaauauuuuauaacaauauuuauaagauucugguuugcuuuuccuuuucgucucguaaa
guuagagagaauugcauaguucgauucuguccaagggggcagcugcauaugguggccggg
cgggucacuggucgu
111 AI1851365 uuuuuuuuauuuuuuauaaguuuucaccacuugugacauucagcauguuacuaucagcucc
agccgcagcguuuuuaaggcguuauagauuaggcaggcaauacaaggaacacgauuaaga
aacugacacguaccacacgagcaauuuccagaggcuccucuucugcggugcacacguaac
aguuucucuuguuncauucagacaguucugaguugccacucugagauugcgccuuccuguuc
ucaccuggacaaauauauuguuuaguuuuggguuugguuugguuuuaccuuacuauagcuuuu
cuuucaacuacauuuugugucaugcuuguuagcuaacucaaauuuugucuuuguauauuu
acuacuguaaaauuagaauaauuuacuguucaucucauccucugucacugauggaaccua
gagacgccacaagagccacuggccaugacauaccucacaagcuacaucccuguccucaaaa
u
112 AW047339 cggccgcagccaccggccuggcgccaagcugcuggcugcggcagccaauaccucggugaagc
ccauuuucagucgcgaccugaacgaggccaagcggagggugcgcgagcucuaccgcgcuu
gguaucgggagcgugccgaacaccgugcacuuaaugcagcuggauaucacggugaaacaa
uacalgauaaaguccgagaaauguucaugaagaaugcccaugucacagaccccagagug
gaugaucugcuggucauuaagggaaagauggagcuccaggaaaccaucaaaguauggaag
cagcguacacacguuaugcgguuuuuccaugaaacagaaacaccaaggccaaaggauuuc
uuauccaaguucuauaugg
113 U06834 Sequence below.
gcaccugagcgcgggugccuggcgcgcccgaugggaucguugagaggcccucgacggaaagucccaaacucggaucgcauu
cagccaaauugaggcggcgccauggagcuccgagcgcugcugugcugggcuucccucgccacugcuuuauaauagacccug
uugaacacaauacuggaaacggcggaucugaaaugggugacuuacccucaagcagaaugccaguaugagggagcuaagcgac
cuggaugaggaacagcacagcguccgcaccuaugaggugugcgacaugaagcgucca
gguggccaggcucacuggcugcgcacuggcugggucccaaggcgaggugcuguccacgugguaugccacgauacgcuucac
caugauauaaugccugucccugccgaaugccagucgcuccugcaagggagacauucacugucuuucuauuacgagagcggaacg
ugauacggccacggcccauacgcccgccuggauggagaaccccuacaucaagguggacacaguggccgcagaacaucugacu
cggaagcgcccuggagcugaagccacagggaaaguuuauaucaagacgcugcgccug
aguccucucaacaaaacugggcuucuaccuaucuuuccaggaccaaagagccuacauggcucuugcucucccugcaucucuuu
uacaagaagugcuccuggcugaucacgaacuugaccuacuuccccgagacggugccucgggagcucguggugccgguggca
gguagcugcguggccaacgcggucccuaccgccaaccccagccccagccucuacugccgggaagauggucaaugggcugag
caacaagucacaugcuggcaggcuugcgcggccaggguacggaggcugcauaaagcaacaaa
guaugcagagccuguggccagggaaccuucaagccccaaauaggagacgaguccugccugccgugcccagccaacagccacu
cgaauaacauugggucuccugucugccugugucgaauuggguauuaccgggcccgcucagacccccggaguucaccuugca
cuaccccacccucugcuccaagaagcgugguucaccauuugaaugguuccacccugcgccuugaguugaguucuccccuug
aguccggaaggccgagagaccucacuuaugcuguucgcugccgagagugccguccuggggguuccugcuugcccuguggg
ggcgacaugaccuucgaccccgguccucgagaccugguugagcgcuggguggcaauccgagggcugcguccugaugucac
cuauaccuuugagguugcugcuuugaaugguguuucuaccuuagccacuggaccaccuccuuuugagccugucaauguca
ccacugaccaugaagugccuccugcaguaucuggacauccgaugacucagucggucacccaggcaacuuuggauccugucauagg
cuauccccagagcacccaguggggccgugcuggacuacgaggucaaguaucaugagaagggcgcagagggccccagcagug
uucguuuccugaagacaucagaaaaccgagcuga
cacggguccgaaucugggcuuacggucccuucggccagggagcauucacagucagacucaacuagauggagaacgagaggcuggc
gggagcagcuggcccugauugcaggcacugcgguugugggugugguccugguccugguggucgucaucauugcaguucucug
ccucaggaagcagagcaaugguagggaaguugaguacucggauaagcauggucaguaucucaucgggcacguuaccaaggu
cuacauuugauccuuuuacuuacgaagacccuaaugaagcagugagggaauuuggccaaagaggauucgauggucuccuauguucaa
gauugaagagguaauuggugcaggugaguucggcgaggugugccggggucggcugaaggcaccagggaaaaaggagagcu
guguggccaucaagacucugaauuggcuacaccgagcgccagaggggcugaguuccugagcgaggccuccaucaugggcc
aauucggagcauucccaacaucauccaccucgagggcguggucaccaacaguGGugccgguuaugauccucacggaauucaugg
agaacggagcccuggacuccuuccugcggcugaacgacgggcaguucacagucauccagcuggugggcaugcugaggggca
ucgccucgggcaugcgguaccuggcugaaaugagcuauguccaccgagaccuggcugcucggaacaucuuggucaacagua
accuggucuguagguguccgacuuuggccucuccagauucuuguaggagaacuccucugaucccaccuacacaaguuccc
ugggaggcaagauucccauccgauggaccgccccugaagccauugccuucaggaaguucaccucugccagugaugccuggc
gcuaugggaucgucaugugggaggucaugucuuuuggggaacggccauacugggacaugagcaaccaggaugugaucaau
gccauugaacaggacuaccggcuuccuccuccuccagacugccccaccucccuccaccagcucaugcuggacuguuggcaga
aggaccggaaugcccagccccgcuuuccccagguauucagcggcucuggacaagauaauccuaaucccgcuagccucaaaa
ucguggccagggagaauggcggggccucacauccacucuuggaccaacggcagccucacuacucugcuuucgguucugug
guugaguguucuucgagccaucaagaugggaagauacgaggaaaguuuugcagcggcuggauucggcuccuuugagauggu
cagucagaucucugccgaggaccuucuccgaauuggaggucacucuggcaggacaccagaagaaaaucuuggccaugugca
gcauaugaagugggaagcuaagccaggagccccuggugggacagggggaccagcccagcaguucagaccuccaaggacuca
ccaccguggcagauucuucuuuccgggaggcagaguuggguggggacucacaagaugagccccucccccucgucacagccu
ucccauuggauuucacuuugaacagagggguucguagacacauauuuugggaaccgugccauauuggaucauacaugugc
ccuccaggcggggaaccccaaacucagagugagucuuucccucaagacugggcaaagaaacaucccuacgucucuaaccucc
caucuucccagaggcucucuccccaagcgccuuccaccucaacgggcaugucccugcagaccaaagagaaagggugaccagc
cugccaacuuuggaguggaaaaugccgucccaggaggcaggaaggugcuuucaggacccggugauguaaucauuuugguuu
ugaugguccugacuugcugucaccaccaaaggcaaucauuuuucccuuguaaaugccccuccccucaucuggccuucauauua
aagguucugaaguuuuacuguuuuuuauuuuguuaauuuuuuccuccuuccccccucccuccccuucuuguccagauuuu
guuuguuuauggcaccugguuccacuaucuccuguugguaacaaggacccaucgauauguucuagaacagugccuuuga
aaugcca
114 AA980204 ggcagcgagacgagcucacggucgaggauacgggugaagcgggacaggagcaggagccgg
agccgugccaaagcagaaggugcaggucugcgccgucgguugggcaugacccauuucaagc
cggacagugaggagcggaugcagacggcacgaccauggccacgauggugcuuccucgaga
ggagaagcugagucaggacgagauagugcugggcaccaaggcggugauccaggguuuaga
gacccugauaggguagcaucgugcccugcuagcuccccuagcuucucaugaagcaggaua
gggcugagcgaucucacaggagcacugccuccuccuacgccgcucccuagagggccaucaag
cuggggcuuggggaggcucaggugauccuggcauuaucaagccaucugggggcuguggag
ucagauaagcagaagcugcgggcucaggugcggcccugguacaagagaacagugguuucg
ugaggagcuggcagggacacagcagaagcucagcgcagugaacaggcgguggcucagcug
gagaagagagcagcacaucu
115 AI843232 ggcagcaagacgagcucacggucgaauauacgauugaagcaugacaggagcaggagccgg
agccgggccaaagcagaaggugcaggucggcgccggcgguugggcangacccagucaagc
cggacagugaguagcggaugcagacggcacgaccauggccacgauguugcuuccucgaga
ggaGaaacugagucaggacgagauaguGcuggGcaccaagGcgguaauccaagguuuaga
gacccugagaggggagcaucgugcccugcuagcuccccuagcuucucaugaagcaggcga
gucugagcgugcucacaggagcgcugccuccuccugcgccgcucccuggaggccaucgag
cugGggcuuggggaggcucaagugauccuggcauuaucaagccaucuaugggcuguggag
ucagagaagcagaagcugcgggcucaggugcggcccugguacaagagaacagugguagcg
uuaggagcuugcagggacacagcauaagcucagcgcagugaacaggcgguggcucagcug
gagaagagagcagcacaucu
116 U59807 Sequence below.
augauguguggcgcgccaucugccacaaugccagccacggccgagacgcaggaggucgccgaccaggugaggcugggccca
ggucaggccagucuuagccaggccugcggagacccgucggccucagugaccggccuucccauacuggucagguccuucagc
guuuuccggggcggccacaaguguaacugggaacugagggcucugGGaucuggugggaaaauucagauccgggaacuag
ggcgagucuucugccgcuugcauacaagagggccacucaccuauuagggaacuagccccgggaucgguggagggauccgg
uggucccagagaauucaggaaggcaguguuauaaccuagacggcaccuuuuugacuuacacccaugccuaaacaagagaaa
gccagacugggcuacugugcuugucuccucaaaagaaagaggcuaggacuguuuagcucaguggcaggaauucaacuaauac
caccaccaccaucaccaacaccgccccucagggaaaaaaaaaaggaucaaaaccagaaguuguagaacaugcuagugccuag
ucugaaacgaggggguggaccuugggccuggucugcccuuccuguuacuguuagcagagcagagauucaguacaagguag
ggauagguucaagguauuaggcaagaaaaaaaaaauuaaacaaauccucucuucaacucuccugccacgccccaagcccagg
acccuguccacuaagccuagcugaucuugggaggaguuugcucugaacugaaguggccaagaaggaagugagucagcucca
ugagacccuagaaaugaggaaauguuacagacacacuggccaggcaagggaaccuuggccacgugccacaucagcacucagg
aggcagagacaggcgagucucucugaauuugaagccagcccaguuucuuaguuccaugccagccauagcuacauagugag
acccugucccccccccccccaaaaaaaaggagcuguguuguucuuuaucaguggggccaacaguuuaccaugucccccggaa
ugaggaguauugaaggcuggcagugugugugugugggggcaccugugcaugaaucuaaguccuuccuucucacccaccau
ccaGGgugaagucccagcuugaaucgaaagaaaaucagaaguuugaugucuuuaaagccauauccuucaagagacagauagu
ggcuggcaccaaccucuucaucaagguggguacugauaguagcuugccaugaacuggggacauagucucagaguagagcag
aguguccugcaacuuccugcagagaaccccuuaaggggacauguacauguucugagaggaugaauuugggguguuagggu
ucccggccuuaaaugaguagacaaggguuaucacuggcuaaguuauuggcuggaggccuuuucuugcucaguuucuaagg
cuggguuagccuggaacuggaaccuuaccuuucacucacaugucugucugucugucuuccuccagguugauguugaugg
agauaaaugcgugcacuugaggguguuucaaccccucccccaugaaaacaagccuuugacccugucuuccuaucagaccaac
aaauaaaggcacgaugagcucuccuacuucuga
117 AI152659 gaaaauguuaagagccaucaaauuucuggauauuuugcuaggaaaaugaaauucuacacu
uauuuuuuguagacuuuuuuuaaaugcuguuuacaugaauuguauuuuggaaaaaauauu
auacuuugcacccugugaugcauuaagugauuuuauguauggucugcuauguggucagag
gucaccuuauuccuaugaucuggaauuguuuacuuucuacaaaguaagcuuuguggggau
uuugcuuucauuuucuuuguagcugauguuauuuuaccaggugugcagcaggaauuacac
cacuguguggaauuauaaauacaucccaugugca
118 AI850090 uuuuuuuuuuuuuuuuuccuggugaauauuuuuauuagaggugacaguuucccaggugac
aguuuuucccaaggaagcaaaucucugcgucuauaagggaagaccacagaaccuucacuu
uguaauuuaccuguguaauuuauccaagaacacagcacagcaauugcuuuaugugguacu
cugaccuuaaguaacaaguuguuaacagaaaacacaucaaacaaaaggauaauucucuaa
uuaucaagucagccaucagcuuuucuuaggauagagagagauaguguguguguuugugug
uguguguguguguaugugucugucugucugucugucuagguaucccacuuagggccaug
u
gcauuuuaguuaaaugcuccaccacuuagcuguuucuuauccgcacuuuucucagauuuc
agguuuguuuguuuguuuuuuguuuuuuaacuaggcaugaaaauaaacuucacuucaaa
u
119 AF064638 See above sequence (AI850090).
120 AI843106 uuuuuuuuuuuuuuuuuguggaaauuacucuuuauugaaaaauaccaguaauacugacag
acuucaaaaucaauuuacgguuccagaauacaaaguacuuaauacauuuuuuuccaaacc
uguuuguaucucaaaguuagcauuuuuguaaaucaagauacaaauaugauaacuucacua
aaauauuuuccagcuuuauucuuuaaggaccuguauaaccuucaaagucagcgucccgag
gucagcagggcauggggcagaaugcaccuggcacucccuaugcagcagacugcaaccaca
uu
121 AF033186 auggccaacuuucccccgaauguuuaacaagaaagagaucggugagaucacacuauaggg
gaacuuucuuggcuccagcagcuccuuuugacaagaaauguggugguuugagaacuggacgguu
gcuuugcuccugauuguuccuacuuuucguguucacaaggauaucgcauagugaagcuu
gucccguuggucccaggugccguaagaacuuucuuuugcaugguuccaaaaauguuaccaau
ucaagcugucuaaaauuggcaagacaaaacaguaaugguggucagaaaaacaagccuccu
gagcacguuauauacuguggagacauagucuggagucuuuucuuuugggucuucaguucca
gaaaaacaaagucguuuggcguuaauauaaaauggcaucaguuccgauuuggacaggaucagg
cuacuccuugccacaggauuaaacaauggucgcaucaaaaucugggauguauauacagga
aaacuccuccuuaauuugguagaccacauugaaaugguuagagauuuaacuuuugcucca
gaugggagcuuacuccuuguaucagcuucaagagacaaaacucuaagagugugggaccug
aaagaugauggaaacauggugaaaguauugcgggcacaucagaauuggguguacaguugu
gcauucucucccgacuguucuaugcuguguucaguuggcgccaguaaagcaguuuuccuu
uugaauauguauaaauacaccaugauuaggaagcuggaaggucaucaccaugauguugua
gcuugugacuuuucuuccugauggagcauugcuagcuacugcauccuaugacacucaugug
uaugucugggauccacacaauggagaccuucugauggaguuugggcaccuguuucccucg
cccacuccaauauuugcuguaggagcaaaugaccuaugguugagagcugugucuuucagu
caugauagacugcauguuaccagccuuggcuugaugauaaaauagugaaguuucuggaaaauc
gaugaggauuguccgguacaaguugcaccuuugagcaauggucuuugcugugccuuuucu
acugauggcaguguuuuagcuucugguacacaugauggaaguguguauuuuuugggccacu
ccaaagcaagucccuaGGccuucaacauuauauggucgcaggucaauuccgaagagugaugucc
acccaagaaguccaaaaacugccuguuccuuccaaaauauuggcguuucuuucuccuaccgc
gguuag
122 Z50159 auggccagcuuucccccgaggguuaacgagaaagagaucgugagaucacguacuauaggg
gaacucuuggcuccauucagcuccuuuugacaagaaauguggugguuuagauuggacgguu
gcuuuuuggcuuccugaugguuccuacuuugcaugguucacaaagauaucggcauaguggaaggcuuu
gucccguggucccagugccguaagaacuuucuuuugcaugguuccaaaaauguuaccaau
ucaagcugucuaaaauuggcaagacaaaacauuaaugguguuucagaaaaacaauuccuccu
gagcacgguuauagacuguauagacauagucuggagcuugcuuuugggucuuuucaguucca
gaaaaacagagucguugcguuaauauagaauggcaucgguuuuccgauuuggacaggaucag
cuacuccuugccacaggauuaaacaauggucgcaucaaaaucugggauguauauacagga
aaacuccuccuuaauuugguagaccacauugaaaugguuagagauuuaacuuuugcucca
gaugggagcuuuacuccuuguaucagcuucaagagacaaaacucuaagagugugggaccug
aaagaugauggaaacauggugaaaguauugcgggcacaucagaauuggguguacaguugu
gcauucucucccgacuuuuucuaugcuguguucauuuuggcgccaguaaagcaguuuuccuu
uggaauauggauaaauacaccaugauuaggaagcuggaaggucaucaccaugauguugua
gcuugugacuuuucuccugauggagcauugcuagcuacugcauccuaugacacucgugug
uaugucugggauccacacaauggauuaccuucugauggaguuuugggcaccuguuucccucg
cccacuuccaauuauuugcuggaagagcaaauggaccgaugguuugagaggcuuguggucuuucaau
caugauggacugcauguugccagccuugcugaugauaaaauggugagguucuggagaauc
gaugaggauuguccgguacaaguugcaccuuugauucaauggucuuuucugugccuuuucu
acugauagcaguguuuuagcugcugggacacauaaugggaaauguguauuuuuuaggccacu
ccaaggcaagucccuagccuucaacauauaugucgcaugucaauccgaagagugaugucc
acccaagaaguccaaaaacugccuguuccuuccaaaauauuggcguuucucuccuaccgc
gguuag
123 X78683 Sequence below.
gaauuccguguuucaaggcgaguuucuguaagcuguuauggguagaggcuggcguugcaccccuuccugaccuucuggugccg
ccgccgccgccuucgggaggaucagacauggcccagaacuugaaggacuuagcuggacgccugcccgccgggccucggggc
augggcacggcgcugaagcugcugcugggggccggggcgguggccuacggcguccgcgaauccguguucaccguggaagg
cggucauagagccaucuuuuuuaaucguauugguggcgugcagcaggacacgauccuggccgaauuucacuucaggaucc
ccugguuccaguaccccaucaucuauaacauucgggccaaaccucggaaaaucuccucccccacagGGcuuccaaaggaccugca
gauggugaacaucucccugcgugugcugucccgacccaaugcccaggagcuccccagcauguaccagcgucuagggcugga
cuaugauugagcgauuugcuuuccuuuccauuuuuuaaugaggugcucaagagugugguggccaaguucaaugccucgcagcuga
uucacccagcaggcucaagugucccuguuugauccgaagaggagcugacagagcacgccaaggacuucaaccucauccuggaug
auguagcuaucacagagcugagcuucagccgagaguacacagcugcuguagaagccaagcaaguggcccagcaggaagccc
agcgggcccaguuuuugguggagaaagcgaagcaggaacagcgacagaagauugugcaggcugagggggaggcggaggcu
gccaagaugcuuggaGGuaacacuugagcaagaauccuagcuauaucaagcuccgaaagauccgggccgcccagaacaucucua
aaacgaucgccacaucacagaaccgaaucuaucucacagcugacaaccuugugcugaaucuacaggaugaaaguuuuacucg
gggaagugacagccucauuaaggguaagaaaugaguguggacaucaagaaccccaccaccagagaaguuggcacacuuguc
cagcuuggaggaggccagcucggauucaagcacagcccacccugccccaggcaucauaugauagacuuuucuguaucuggccc
ucuuggauuaggaagacugagaccagcccuuucagaggcuuuccuccuuccuguguuggcugggaagcgggguggacaa
ugugauuucuccgugauuuccuacagccuugagccucucccagagugggggagauaaccaccaugccaggaauuc
124 X68193 acccaccggcuuucagaccauggccaaccucaagcguaccuucauugccaucaagccagga
uggcgugcagcgcggccuggugggcgagaucaucaaacgguucgagcagaagggguuccg
ccugguggccaugaaguuccuucgggccucugaagaacaccugaagcagcauuacaucga
ccugaaagaccgccuuucuuucccggggcugglugaaguacaugaacucggalcccgualu
ggccauggucugggaggggcucaauguggugaaaacgggccgagugaugcugggggaga
c
caauccagcuuuucaaaaccaggcaccauccguggggauuucugcauucaaguuggcag
gaacaucauucauggcagugauucaguggagagugcugagaaagagauccaucugugguu
uaagcccgaagaacugaucgacuacaagucuugugcccaugacuggguguacgaguagac
augaauuaaaccagaauccuuuucagcacuacugaugguuuucuggacauuagcucuucauc
ccacugacaggauggaucaucuuuucuaaaacaauaaagacuuuggaacugaaaaaaaaa
aaaaaaaaaaaa
125 AA062013 uuuugcuuucaacaugacagaugccgcuguguccuucgccaaggacuucuuggccggugg
aguggccgcagcaucuccaagacagcggucacaccaucgagagggucaagcugcugcugc
aggugcacaugccagcaagcaaaucacggcagauaagcaauacaagguucaucauagacug
cgugguucauauccccaaggaacagauaguggcuucugguuccuuuaggcggugggaaccgggc
caaugucaucagauacuuccccaccaaggcucucaacuuggccuucaaaguuaauuccaa
gcagaucuuucugggugguguugacaagaggacccaguucuggcgcuacuuuugcaggga
accugggcaucaagugguuaccacugggggcuacauccuuugaucuuuauguacccucuugau
uuuugccgguaccgucuagcagcugaugugggcaagcuggagcuaaagggaauucaaggg
ccuugggacugccugguaagacuucaaucugaugggauaagggcuguac
126 A1465965 auccgggacccccacggccccuuugcagcuugccacaagguucugagccccuuggaauac
uuccgccaauguguguaugacauguuuugcccauaagggugacaaagccuaucucugccgu
agccuggcugcuuauacugcaggccuucaggcagcuggggcagcaguaaaacccuggagg
acagacagcgucugcccucuccaguguccuuccacagccacuacuccaucugcacccgc
uccugccagggcuuccugugcugcucucucuggccucacuggcugcaccac
127 U50413 Sequence below.
ggcacgagccgaguuggaggaugcagcggcagcguucagcggcagcgguagcuugugauugacggcugugcagccaaggaucc
gggacagcgaagcgacggcaggucgcagcuggaucgcaggagccugggagcugggagcuucagaggccgcuguagcccag
gcugggcagaggaaggaugcgagccuucccuugaggugaugcugagaguggagcguggcaguaaaaucagacgacagaugga
cagugugacaggaucgucagagaggauugggccucgcuuucgagagucagccuggagucaagguuuuugacauguugcugag
aaggacacguaugagggacaguggcgcgcggagggaaagcccugucuucagucaccccguuugauggaggacagauggacag
cagccggacggccagucuccucucuuuaaccuuuggauagugguccuuugugcucugcuggacaccuguuggggauuuua
gcccauucucugaacucacuuucucuuaaaacguaaacucggacggcagugugcuuagccagcuccucuguggcauuggcacu
aaagcugcagacaugaguacaaaggggcuuaccaguacagagcacuguacgacuacaagaaggagcaagaggaagacauugac
cuacaccugggggacauacugacugugaauaaaggcuccuuaguggcacuuggauucagugauggccaggaagcccggccu
gaagauauuggcugguuuaauggcuacaaugauaccacuggggagaggggagacuuuccaggaacuuacguugaauacau
uuuaaauaaaaaaauuucacccccuacucccaagccucaucccccuucaaccgcuuccuguuggcuuccgggguucuucaaaaacu
gaagcugacacggagcagcaagcguugccccuuccugaccuggccgagcaguuugccccuccugauguugccccgccucuc
cuuuuauagcuccuggaagccauugagaagauaggacuggaauguucgacucuauacauacacauagcuccagcaucccug
cagaauuuacgacagcuucuuggauuuguaaugccggcgucaguagacuuggagauggauucgacguacacucuuagcaggauugcu
cuacagagcccugaagacugcauccagcuguugaagaugcucauuagauugccuaauauaccucaucaguguuggcuuug
cuucaguauuugcucaugcauuuuuucaagcucucucaugccuccagcauaaaccuuuugaaugcuagaguccucucugag
auuuucagccccgugcuuuucagauuuccagccgccagcucugauaauacugaacaccucauaaaagcgauagagauuuuu
aucucaucggaauggaaugagagacagccagcaccagcacugccccccaaaccucccaagcccacuacuguagccaucaucag
caugaacaucauuauguccuugcaguuaugcugaaugguacuggggagacaucucaagggauguagugaaugaaaaacuccg
agacacuugcugaugggaccuuuuuugguacaagacgcaucuacuaaaaugcacagcgauuuacacuucuuacaccuaggaauau
aggaauuaacauauuauucaaaaucuuucaccgugauggaaaauauggcuucucugauccauuuaccuucaucucuguggu
ugaguuuauaaaccacuaccggaauuuugucuuuugcucaguacaaccccaugcuggaugugauguugcucuacccaguguc
caaauaccaggcagggaucaaguuugucaaagaagauuauuauugaagcuguaaugaaaaaauuacaugguauauuaauacucaauu
ucaagaaaauagucgggaauaugauagauuauaugaggaguacacccguacuucccaggaaauccaaaugaaaagaacggcu
aucgaagcauuuuaugauaccauauaaauauuugaagaacaaugccauacccaggagcuuguacagcaaagaauacauagaga
aguuuaaacggcgaaggcaacgagaaagguaauuucaaaggauuaugcauuaccaugauuagcugagucggcguaucagugaga
ucauugacaguaggaggagguuggaagaagacuuguagaagcaggcagcugaguaccgagagaucgacaaacgcaugaaca
guauuuagccggaccucauccaguugagaaagacaagagaccauuacuugauguggcugacgcagaaaggugugcggcaga
agaagcugaucuuaguggcugguugaaugauauuaccgaagaucuauucucccugguagaagaugaugaggauuugccccacc
augacgagaagacguggaaugucgggagcagcaaccgaaacaaagcggagaaccuauugcgagggaagcgagacggcacuu
aucaagacugccaccggcuauggcuuugccgagcccuacaaccuuuuacagcucccugaauugagcuggugcuacauuuucaa
cacaccucccucgugcagcacaaugacucccucaaugucacacuagcauacccaguauaugcacaacagaggcgauguagcg
cugcccucggauccaguuccucaccuucaugccacccauggccucugaguagcauagggcuccucuccagcccgaccuguga
acugagcugcagauaugaugccggcugucugcacaugggacuagagcuuucuuggacaaaaagaagucguuggaugacacgc
aaccucuacuauuggaugaccagacguucuaaccuuuauccucuuucuuucuuuucuuucuuuucuuuucuuucuuucuuuc
uuucuuucuuucuuucuuucuuucuuucuaauuuauagccacaucacacaaccaucacacagagagauagauaugcaaauau
cucuccgugcagggacaaagauugccuuuuaccauguugcuuguuuacgcuuucuguagcuuuuccagcuacaaguugguuac
uuuuagagaccagauggguagacagggccgaagagccugcaccuggggccgcuugguccagccugguauagccuaugugucg
cuggguguggugaacccagacacaucacacuguggauuauuuccuuuuuaaaagagcgaaugauauguaucagagagccgc
gucugcucucgcaggacacuuugagaguacauugauuucagucuguucggaggauauaugaucuccagaauacguuuuugu
uuauacuuaucaaggucaacaaccaacaacccaccaacagaaaaaaaaaaaaaa
128 AW120502 uuuuuuuuuuuuguuuuanuuuggcuccaaugaucgcauucucaaacuccuuugggagg
g
cauuagaugacccaguauccuuacuuacuuagauucacacuuuguuuuucuccucugagcucu
uuucuccaggcucacngucuuuguuuuucaaggcuuucuugauccuuugaacaauuuucuu
ccuuugaagauucuccugg
129 X62940 Sequence below.
agccgaguaggaccgagcugcugcagacgcucgggucacucgagccagcaccaccuucucacgcccugagcugcagaca
gcuaggcgguuuuaucuaguuugaaccaggcugcuggagcuugcucccucccgcccucucucuuuuuuuuccacggggcu
guuuuuuuuauuuggcugcuauugcaugauaucccaaugguguagaccaguggcgauggaucuaggaguuuaccaacuga
gacauuuuuccauuucuuucuugucgucuuugcugggaaccgaaaacgcuuccgugagacuugacaauagcucuggugca
agugugguaacuaucgacaacaaaauagagcaagcuauggaucugguaaaaaaccauuuaauguaugcggugagggagga
aguggaaguucugaggagcagaucaaagaucuuauagagaaaaacucccagcuggagcaggagaucaaucugcugaagac
gcuggccaguccggagcagcucgcccaguuucaggcccagcugcagacuggcuccccuccggccaccacgcagccacaggg
aaccacacaggcccccugcacagccaacaucccaaggcucaauaucaaccacauagccuccuaggccccaacagaacuagcugg
cugcugcugcugucugaacugaacagaccgaagagaugugcuagagagaagccgccuccacagucacccauuucauugcug
ucuacgaaagagacgugagacucacacgcuguucucgcuuucuccccaguauuaagcacucauaagcuuuuggcuugaaga
aauguacuagguugaaugaauuaauaguuaaucagagaguaagcagauauguacccuguggcaacgguggcagaugucuaagg
aaugguuuaauugaccccgaggagcucugugccuuuucaacccuccccagccgcccacccugcuucugagagcucugcu
cucgccuucguggggcucgccugcgugggguucgaaagugggcugcuccuggauucugcgcucucuucuccuucccuuca
aaaaacucggaggaggccagaaacaaaacugcaauauggggcgggggggagggaugaugcaguccuuauacaaaaccaacaac
ugucaccaaagcuuuuaaaacacgauaguacugucccucuuuucugaaccaucagaagacacaaaacuguuagugacacaac
ggugacagguagcugggaccuaggcuaucuuauuaugaagguuguuuugcuuguuguauauuuguguauguaguguaac
gaauuuguaccauagaggacuguccguaacuacuguuuagcuucuacacauugaaauguagauguuucauuggcugucug
aaaauuguggcuuguccuuccuagagagaucuacuuuaaaacugcuuuguggcaaaaaccacaccugaagaaauuuuaug
auuuuggcccaguuagucacucuguguaaucccggauucuagcugcugaagucuugcgaaguaaacuccccgugaccgaug
ucaguuaagcuggugauaccuuugagaaguggucaguugcuaaggaaguuugauuucccagguagguuguuucugcaccucacc
uguauaaucguucugcgcaugucccccacacaguccccaccuguauuuaccuguucuacuuaucaccuuucauuauagcau
aucauauguugau
130 U60020 Sequence below.
auggcugcgcacgucuggcuggcggccgcccugcuccuucugguggacuggcugcugcugcggcccaugcucccguugaau
cuucucccuguuauucccgagguggccggcugcuccgggucuggguagugggccuaagucgcuaggccauccuaggacuag
ggguccgcugguccucggggucaccgcaggagcccauggcuggcuggcugcuuugcagccgcugguggccgcacugagu
uuggcccugccuggacuugccuuguuccgagagcuggccgccuggggaacacuccgggagggugacagcgcuggauuucu
guacuauaacaaucguccagaugccuucacuaucaguuauguggcagcauugcccgcagccgcccugugggcacaaguuggg
ggagccucugggcgcccagcucaacagggacgcuggagacaugcugugucggaugcugggcuuccugggcccuaagaag
agacgucucuuccugguucugguucucuugauucucucuuggcuuggggaaauggccauucccuucuucacgggccgcau
cacugacuggauucuucaggauaagacaguuccuagcuucacccgcaacauauggcucauguccauucucaccauagccag
cacagcgcuggaguaugcaagugauggaaucuacaacaucaccaugggacacaugcacggccgugugcacagagagguguu
ucgggccguccuucgccaggagacaggguuuuuccugaugaacccagcagguuccaucacaucucgggugacugaggauc
agccaacgugugcgaguccauuaguuuacacgcugagccugcugcuuuugguaccuggggcgagcccugugucucuuggugu
ucauguuuuaggggucaccguaccucacucuggucacccugaucaaucugccccugcuuuuucuuuugccuaaggaaggcug
ggaaaagugcaccagucacuggcagugaaggugcaggagucucuagcaaaguccacgcagguggcccuugaggccuuuucg
gcgaugccuaccgugcggagcuuugccaacgaggagggugaggcccagaaguucaggcagaaguuggaagaaaugaagacg
cuaaacaagaaggaggccuuggcuuugucgcugaagucuggaccacgagugucucgggaaugcugcugaaggugggaau
uucuguaccugggcaggcagcuggugaucagagauacugucagcauggcaaccuuggucuucauucguucucuaccaacuuc
agaucacccaggcuguuuucaggaccagcucucccuuaccccuccaugcagaaggcugugggcuccucagagaaaauaaucg
aauacuuggaccggacuccuugcucuccacucaguggcucguuggcacccucaaacaugaaaggccuaguggaguuccaag
augucucuuuugccuacccaaaccauccaaaguccagguuucuucaggggcugacuuuucacccugcauccuggaacgguga
cagcguuuuggagggacccaauggaucagggaagagcaccguggcugcccugcugcagaaccuguaccagcccaccgggggcc
agcugcugcuggauggccagcgccugguccaguaugaucaccauuaccugcacacucagguggccgcagugggacaagagc
cgcugcuauauggaagaaguuuucgagaaaauauagauuaugucugaaccggacuccaaccauguuaggaaaucacagcug
uggccguuuagucuggaacccacgauuucaucucuugauuucccucaggggcuaugacacaaagguagguggagacuugauaac
cagcugucaggaggucagcgacaggcaguggccuuggcccgagccuugauccggaagccacuccugcuuaucuuggauga
ugccaccaguuucccuggaugcuggcaaccagcuaugguccagcggcuccuguaugauuagcccaaugggcuucucggac
aguuucaucuuauucacccagcagcucagccuggcagagcaggcccaccacauccucuuuucucagaggaaaucucuguucggc
ggagcagggcacccaccugcagcucaugaagagaggagggugcuaccgggccaugguagaggcucuugcggcauccugcagacug
a
131 L32752 gaauuccggggccgcucucuccggcaggaucgccgcgauggccgcccagggagagccgca
gguccaguucaaggucguccuggugggcgacggcggcaccggaaagacgacauucaugaa
gcgccacuugaccggagauuugagaaggauuauguagccacccugguucguguuagguuuca
cacauuagucuuccauuaccaacaaaggaccuaucaaguaucaauguuguaugacacagccu
ucaggagaaguucggggggcugcgcgauggcuacuacauccaagcccagugugccauuau
aauguuugacgguaacaucaagaguuuacuuacaagaaugugccuagcuggcauaaagaucu
agugcauguuguggugaaaacauccccauuuguauaugguguggcaacaaagguggauauuaaagga
caugaaagugaaggcaaaaccuaaucucuuccaccgaaagaagaaucuucaguacuuuauga
cauuucugccagaaguaacuacaacuuugaaaagccuuucuucuggcuugccagaaagcu
cauuauagauccuaacuuggagguacguugccauuggccuacuucuugccccaccuaagguagu
cauggacccagcuuauggcagcacaguacgagcaugauauagagguugcacagacgacugc
ucucccagaugaggaagaugaccugugagaaagugaagcuggagcccugcgucagaaguc
uauuuuaggcaacuuguccuggugauggccagccaacgguacauguuguggugccaccuuauuuu
agcaaaaggagaucgagcaauucauugggaugcugaaggagaugaaugggcuucggagug
aauguggcaguuuaaaauacaccuucauuuuuuuggacuugcguauuuagcccccuggaac
agaguuuguucuggauuucaaagauaauuacugcuaccguagcaucacaauagucaguggug
accggaauuc
132 AI8400413 uuuuuuuuuuuuuuuuuuugauuuuaugaaaaguuuuuauuuuuaucaguacuuguaaaaaauucuc
aucauaaaugcuacguuuaaucaaggaaaaggcacagagaagcaugugucguuugaguccu
cgauacuggaccucccagcccaugcucccuaugaggaucuagcugcuguggaggucuuc
acagcauugguuuucuggagacuuaauucucaugauugcguucaugcacuccucugacagcc
accuagcaugcagaguaguuugcacucaucagcgaugacugcguagagcuuuuacuaucucau
uuuuaucugauuaacucuuuuggaaauuucucauugggauugcugagagcuucgcauau
133 AB020424 ucgggaaucgauugagagaccgcgaaccuguaaacggaugauaccgagucgggcaggcgu
uaugccagcccaacucgggaccucgcaucauguccgcggcuaccuuagaguuuucggga
augauuuuucgguuugaugaacgaaaccccgguacguccugugccaaggagcauaugucagg
acggacgcucauuaaugccucagugguggggcaacguucgcucucuaucuauacgacucu
cgacaauggauaucucggcucucgcaucgaugaagaacguagcgaaaugcgauacuuggu
gugaauugcauauccugugaaccaucgagucuuugaacgcaaguugcgcccgaggccuu
ucgguugagggcacgccugccuggacgucacgccuuuguuuugcucuugugcccgugcucuu
ucgggggcggucauggaugcggagauuggcccuccgugccucgugugcggcgggcuuaag
cgcggggugucggcgucgggaagggcacgacgagugguggacggagcaccagcaggaugu
uuuuggucccccuuucaccuuaaggggcucaagagacccggacuagguagccgcgcuucgu
aagaggagggcgagcugucucgcaau
134 AI848453 uuuuuuuuuuuuuuuuuuuugaaguugcuggccccuuuauuagugacccgggcaaguuuuaagga
gaacaacauuaaagcacacaaaguguauccaugucaccagcucaaccaggaggagugagg
gucacggcaggguucucccaugguguaagaaaucaacgcaauuucaucacaccccguuac
uuuuccaaguuaacgaaccgauaagaaaagauuucucccuuaaacugacaaguacaauguac
auguacaugauuuuggaauaauuuaauacuuuaaccucaagauacaacuauauucuaaga
ccauuauuuuaaaggaacggauccuuacaaaaccaaaauaacccauauagcacgagguug
guuuagccuuucuucuucuuucaacaaacgugcaccacauguuucaguagcaaggccgau
gccauggauaugagagcugugauuugcagggaccaaccacaucuagaaccggggaggcca
aucauacgguggguu
135 AU040563 cccuuggaggauaguuuuauugacaagucgaguuagguuuuagaguaaacuuuuaucacc
ccagucaggccccuucccaggggaggcucgcugguagcucagauggccuugguggugggc
agauuguuguaguugucuuccuguucccuccagcaggcuucgggagguggcuaucuccuu
uccagccuggacuugauguccaguagcugcuuauacuccggguucuggcgcucuaugugc
ggcacgcaggugcngcg
136 X89749 Sequence below.
agacugacuuccuugagcagauuaccucuccuccuucucaugccagagacugcugaugaggaaagguccaggggacugucc
augcugucuucauccucagagucacugccugaugcugcaacaagacccuucuuguuuagcaauagugguuggaacacucuc
uuguaaguuaccggagcacuaguauaggaggaggaucaucgacuacccucccgccacuccacggcugcuggcuccuagaaa
ccccagcuucaccucucacugggacucgaguuccagaaugaaaagcaagaagggucuuuguugcagcaucaggcagugacuc
ugaggaugaagacagcauggacaguccccuggaccuuuccucaucagcagccucuggcaugagaaggaggagaggcaaucu
gcccaaggagucaguccagauucugcgagacuggcuguaugaacacagauacaacgccuaucccucagagcaagagaaagca
cuugcugucccagcagacacaccuauccacacuacaggucuuguaacugguucaucaacgcccgccgcaggcuccuuccugaca
ugcugagaaaggauggcaaagauccaaaucaguucacgauuucccgccguggggccaagauuucagaagcuagcucuauug
aagcugcaauggguaucaaaaacuucaugccaacucuagaagagagcccauuucauuccugcguaguuggacccaacccaac
ccuagguuagaccagugucucccaaaccucccuccccaggauccauuuuggcucgcccuuucagugaucugccauaccacuuuu
gacugcauugaaggaugggccuuuucucucuucugucagccgauuggugugggacagaguacagauguaccgcaaauuagcac
ccagcaacuuuacagacaccucucucguguacccagaggacacuugcaaaucuggacccaguccaaacccucagaguggucu
uuucaacacuccucccccuacuccaccagaccucaaccaggauuuuauuuggauuccagcuucuaguguuauguugcacucaa
acgagcggcagagauggagcuucaggccaaacucacagcuuuaaccguuuuuucaaacaaaacaguucuccaaaauacggucc
ugauugccgggggugauggcaagagaugcauuuuuuauauauuuuuuc
137 AW125390 uuuuuuuuuuuuuuuuuggugguuaucaagugcacuuuauuaaauccacuguggauaggau
aaaugaguguuacaccugcguguagggaggggcaaggagggacgcagcugcggaggguga
agcacuucaggaccggaagucggaauccucuauuaagugugaagguuuugagcguuaaga
acaaugaugaugacacuaacaaugggugauaacaaccaucaggaugcugaauaccaaggugg
cugauguucaggcacuuagcaguggaggcguaggccugggcuccagucacaucacccacc
aucuuccgaucccuagacuucacggaguaggcauaggcuaugaagcccaggcagcagaag
uucaugaagaguguauugaacagggaccagaccacauggucaggcaccgacaccucucug
ggcauguugaucacaguaguucugacagaagccga
138 X0582 Sequence below.
aagcuucaggauacagugcacacucgguaaauaaaaacuacaggcugcugcgaauuauauuucaacuuuaccggagaggcaaa
accugacuguccauuaacccuuaacuuccaaacgcaaacuacuuacuggcaucuuuuggcauuuuaccuuaugccuuguuag
guucaaggcaagagaagcgucaucaauaaccacgcaugugcaacagcuuuuccagaggaaagguguggguggcucuuaaaa
gagccuuugagauaggauuugugaguuaaacgagcucacuuggagcugguguacuuggugacugccuuggugcccuccgac
accgcaugcuuggccaggcuccccgggcagcaggcagggcgcacggccgucuggaucucccgggacgugauggucgaacgcuu
guuguaaugcgccaggcgggaagccucgcucgcgaugcgcucgaagaugucgaucacgaacgaguacaugaugcccaugg
ccuuggaggagaugccggugucggggugcacuugcuucagcaccuuguacacguacaccgaguagcucuccuugcggcug
cgcuugcacuucuugccguccuucuucugggccuuggugacggccuucuuauagcccuucuucggaucgggagcggacu
uggcgggcacaggcauacugagaggaugaagugaacuaaguagaaaaaggauaacuaaaaguuaaugacuguucuggcug
caauuuuaaacaaacuuacggcuauggcaaccugaaucaccauacgucauguacuaacaguccaaucaaaacaagggauuuu
caaaccagggcgccauuaguaaccaauguguaaccaaugaaaucucuccguuuucgcguccaaccuugacuauauauacua
ugcguauacgauuuugcuucauacugcgguggauaucaacagcugaguuaugucuggacguggcaagcaaggacguggca
agcaaggaggcaaggcccgcgccaaggccaagacgcgcuccucccgggccggccugcaguuccccgugggccgcgugcacc
ggcugcuccgcaagggcaucuacucggagcgcgugggcgccggcgccccgguguaccuggcggccgugcuggaguaccug
acggccgagauccuggagcuggcgggcaacgcggcccgcgacaacaagaagacgcgcaucaucccgcgccaccagcagcugg
ccauccgcaacgacgaggagcucaacaagcugcugggccgcgugaccaucgcgcagggcggcguccugcccaacauccaggc
cgugcugcugcccaagaagaccgagagccaccacaaggccaaggggaagugaaaccaaacauuacgaaucaccaaggcucuu
uucagagccacucacuuucucaaagagaccuaacacuacugggauaaugcauuguaugaaauacguauauuaaccuuccuc
cuauuuucccugcuugugguuaguucaaccccuaagccuuaggcuaagaguauauugguuuuggaaggcaggcacccaa
ccucggaccuagguacauaaaacagacacaucuugaacuccaggccagccuacucugcaggacgaguuccaggacagaccgga
cugcacaaaaaauugucuugaaauguuccuuuaucagcacauaugcugauaaacaacuaaucacuguacaaucaauccucac
uuugaauccuguuuauguggcaugauugacaaguccugccauauggcaaagucaaaaucagcaaaggaugauaaagcauua
ggugguaucacagcuaaaac
139 AW046181 uuuuuuuuuuuuuuuauggcaaauaguuuucaagauuuuuauugcaaaccaaaauugguuu
a
ucgcacacaaaaaaaguugugugguaaggaggaggaauuguacaggauuauaacccaugu
uaauuacagguacauuaaaauggaugguuuacaaauaagccugguaaguuuaaauaucuaggug
uuauaacccaauguacagacuuccuuuacacgauacauacaauaaucaggaaugcaaaag
aauaugaacaaagggaaaaaaaacauaaauaaugcccguuuuauaggugacauuuauuaaac
aauugaaaacaccaaccagcuuugacugacaacuagggcauuggguccauaaaaacccuuu
cuaaaaauagaaauau
140 U10118 Sequence below.
gaggcugcucaagagcugcgguugggucaccgcuucauguuucucugccgauucuggggaaagauggcaacgaaugaugc
uguucugaagaggcuggagcagaagggugcagaggcggaucagaucaucgaauaucucaagcagcagguugcacuucuua
aggagaaagcaauuuugcaggcaacaaugagagaagaaaagaaacuucgaguugaaaaugcuaaacugaaaaaagaaauaga
aaagcuaaagcaagaggcuugauccuggcagaaauucauaacggaguggagcaagugcguauucggauuugaguacuuccacuugca
gacgaacuguacugcuucugaaaguguggugcagucuccaucaguagcaaccaccgccucuccugcuacaaaagagcagau
caaagcgggagaagaaaagaaggugaaagagaagacugaaaagaaaggagagaaaaaggagaagcagcagucggcagcagca
aguacugacuccaagccuaucgacgcaucgcgucuuugaucuucgaauugguuuuauuuuuacugccaagaagcacccugau
gcagauucacuguauguggaggaaguagaugugggagaagcagccccgcgcacgguuucgucagcgggcuggugaaucaugu
uccucuagaacagaugcaaaaucguauggugguuuacucuuuuuaaucuuuagccugcaaagauuucggguuguucugucuc
aagccauggugauguguuuccaguucaccagagaaaguggagauucuggccccucccaacguuguccguuccuggggacagaa
uuacuuuugaugcuuuccuugggagagccugacaaggagcuuaaacccuaagaagaagaucugggaacaaauuccagccugacc
ugcacaccaaugcugaguguguggccacauacaaaggagcucccuuugaggugaaggggaagggaguuuugcagagcccaaa
ccauggccaauaguggaauuaaauaagugcucuguaacugaaauuacauuguucgaaaacuuuuaacaauaaagagaagugu
gguuaucacuuacauau
141 AW212775 ggccuuguuuuugguuugcaauaaagaguauuucuuuaaaaggcacauuuuguuaaauag
gcaguuccccuccugccucuuccuuuguagcaguguacugcauccuagaaacauuuagca
aagcagcccuuagccuccccgacccccuuucccucccucccagca
142 AI846302 uuuuuuuuuuuuuuuuuaaacaauaacaccgucuauuuaaaauguuuacucccaaaaauua
uagauauaaaaaaaaaaauaagacaauuaacagcacuaaaccaggcaccuucaaccgaau
cccaccauccucguuaacucccuuccuguuacccuuuguagaugaccagaagauuucagg
agccccuggacagccagagugguuccugcccagggcuucccgccuuccuccuuuccuaga
gcuucccgugggaaagcuugggugagaauuuuuagccuaaagggagggggcuguggccgg
g
cacuugcgcucauccacucuagg
143 M22998 Sequence below.
acaggguacaguugugcgucagggcguggaggucuggcgggagacgcauaguuuuacagcgcguccguucuuuccgucucgcag
ccggcacagcuagagcuucgagcgcagcgcggccauggaucccagcagcaagaagguuuauggccgccucauguuugcuuuu
aggagggagcaguacuucggaucacuugcaguucggcuauaacacuggucaucaacgccccccagaagguuauuuggaggagu
cuacaaucaaacauggaaccaccgcuacggagagcccaucccauccaccacacucaccacgcuuuggucucucuccguggc
caucuucucugucgggggcaugauugguuccuucucugucggccucuuuguuaaucgcuuuggcaggcggaacuccaugc
ugauggauugaaccuugucggccuuuugguggcuacuuguacuuaugggcuuucuccaaacugggcaaauccuuuugagauacuu
gauccugggccgcuucaucaucgguguguacugcggccugacuacuggcuuugugcccauguaugugggagagguuugucaccuac
agcucuacguggagcccuaggcacacugcaccagcugggaaucgucguuggcauccuuauugcccagguguuuggcuuag
acuccaucaugggcaaugcagacuuguggccucugcugcucagugucaucuucaucccagcccugcuacaguguauccugu
uugcccuccugccccgagagcccccgccuccugcucaucaaucguaacgagggagaaccgggccaagaguuguggcuugaagaagc
uucgagggacagccgaugugacccgagaccugcaggagaugaaagaagaguuucguucagaugaugcgggagaagaagguca
Ccaucuuggagcuguuccgcucacccgccuaccgccagcccauccucaucgcuguggcgcugcagcugucccagcagcuuu
cagguaucaauugcuguguucuuacuacucaacgagcaucuucgagaaggcagguaugcagcagccuugugguacgccaccaucg
gcuccgguaucgucaacacguuccuucacuguggugucgcuguuuguuguagagcgagcuggacgacggacccugcaccuc
uuggccuggcuggcauggcaggcugugcugugcucaugaccaucgcccuuugccuugcuggaacguucugccuuggauuuuc
cuauucugaacaucguauccaucuuuuggccuuuguggccuucucugaaguaggcccuaguccuauuccaugucauugugg
gccgagcuguucagccaggggccccguccugcugcuauugcuguggcuggcuucuuuccaacuggaccucaaacuucauugu
gggcauguuuccuccaguauguggagcaacugugcggccccuacgucuucaucaucuucacgguuucuccucgugcucuucu
uucaucuccaccuacuuucaaagucccugaggaccaaaauccaaaccuucgaugagauucgcuuccggcuuccagcagggggaug
ccagccaaagugacaagacacccgaggagcucuuccacccucugggggcggacuuucccaagugugaggagccccacacccagc
ccggccugcucccugcagcccaaggaucucucuggagcacaggcagcuagaugagaccucuuccgaaccgacagaucucgg
gcaagccgggccuuggggcgccuuuccucaaccagcaguggaagguccaggaggauauucaauacuuugauggcuccagaauuuu
uuuuuuuuuuaucagccacucuccuaucuccacacuguagucuucaccuugauuggcccagugccugaggguggggacc
acgcccuuguccagacacuugccuucuuugccaagcuaaucuguagggcuggaccuauggccaauugacacacuaauuaccgaa
cucugagcuaggaggcuuuacgcuggaggcgguagcugccacccacuuccgcaggccuggaccucggcaccauaggggucc
ggacuccauuuuaggauucgcccauuccugucucuuccuacccaaccacucaauuaaucuuuccuugccugagaccaguug
gaagcacuggagugcagggaggagagguagggccaguucugguucugccagguucuagucuccugugcacugagggccaca
caauaccaugaggaaagaccucggaagcuggagaacuuaacuugcugaagacacggacacuccugcccugcuguguauagauug
gaagauauuuauauauuuuugguugucaauauuaaauacagacacuaaguuauuaguauaucuggacaaacccacuuguaa
auuacaccaacaaacuccuuuuuaacuuuaccuaagcagauuauaaau
ggcuggguuuuuuag
144 X64837 Sequence below.
gcuuucuaaacuagcaagcaucguguggguuuccuucaggagugggagugcagacagaccugacagcguccgcuaagcgacac
agaguccacaccucaguucgccucuggccacggucuuguugccacaaagaagacagagcaaggcccaccauccuccggaguacauuu
uugaacgggaaucuaaauauggugcacacaauuuaccauccuuugccuguagcccuggagagaggaaaaggcauuuauaugu
gggauguggaaggcaggcaguacuucgauuuccugagugcuuauggugcugucagccaaggacacugccacccaaagauca
uuagaugccaugaagagucauuguggacaagcugacauuaacaucucgggcuuucuauuacaauguccuugguuauuugagg
aguacaucaccaagcuuuucaacuacaacaaaguucuccuuaugaauacaggaguggaggcuggagagacugcauguaagc
ucgcucgucguuggggcuacaccgugaaaggcauccagaaauacaaagcaaagauuguuuuugcugaugggaacuuuugg
ggucuuaacacuauucugcaaucuccaguuccacagauccgaccaguuuaugauggcuuuuuacccuuucauugccaguucuuuua
accaucccauauaacgaucuggcccgcacuagagcguugcucuucaagauccaaauguuugcugccuucauauuggagcccauc
cagggugaagcaggcuuaucguuccggauccaggauaccugacaggaguucgguacucugcaccaggcaccagguccug
uuuauugcugaugaaauacagacaggauuggccagaacugguagauggcuggcuguggaucaugauaugucagaccuga
uuaugguucuuucuugggaagggcccuuuuucuggcgguuuauacccugugucuugcaguacuuguaugacgauaagauaaugcug
accauuaaaccaggcgagcacggcuccacauacggcggaaacccacuuuaggcugccgaauugccauugcggcucuugagguu
uuagaauggagaaucuuugcuugaaugcagacaagaugggcgcuuauccugaggaaggagcucauugaagcuuccucuugac
guuaugaccucaggugagagggaaaggguuuggcuuaaaugccauuggucaucagagaaaccaaagacuuguaaugcuuuuaaau
gugccugcgacuucgagauaugggcuucuggccaagccaacccacggugauaucaucaggcuuucccuccccuugugau
caaggaggaugagauccgggaguccguguuagauucaucauaagacuaucuuguccuucugagauuuuaggaacucuggggag
ccaucuuuucagacagggcucuuaugaaacucuacuuacaauggccaggaucuugucuuccugaaaggcauauauuucaauuga
uugagguuugacugugugggaacuuucuaaggagaaacggacccaucugcguacagccugcagauggaggccugcaguca
uuuauugcgucuuuacaguuuccuugcuuuguuaugguuuguauuuagaaguuauuucugagauacuacagaacagu
uaaaucauuauaaucaaugaauguuaaguugauugaagguuaagcauauguaaaauacuaguuuuaaaguaaacuuuuucauu
ggccaacaccagaauguauuauauagauucugagaauucauuacuaaauuacacuuugcuugauugcaauuuguaaaacau
uuauuuuucaguauuucuuuuauaaagcuuaauguuucuuuuuuacgccaacauguauuauuuuuauuuccauuuugguaau
aaucaauguauuuuuucauccugaugacuggcauuuucaucaccuauuugagaucacuugggguguguuucagggccuuuuuauuc
uaaauaaagcuaugaccaguuucugucugu
145 AI843119 uuuuuuuuuuuucuuuuccgacgcccacaagaggaauuagagauuuaaugauagauagua
uggggaaaucacaguuuucagacaugaguaaucaaaaacuugacauuuuucuugauaucc
aaaucuagaugucuguaucaaaccagaggugauggccuuggggauggcagugaagacugu
uaggaccauuagaucagau
146 AI837786 uuuuuuuuuuuuuuuucaguuuuuaaucaauucucagucuuucucgggcugaugcaau
u
gcaagaacguauugguauugguauauuucagcuacauacaagguuuaugauuagcaaugg
agauaaauuaguuauuuuaauauugacuucauauagagauagugcaauguuguuuguuuuu
cauaucacuugcuugacagguuuguggggguuuucuucccuaucauuuuuaacaaucaagaua
acauggacucaagacagaauuuuucgggaaccucacucaguccucacacagcagugacuu
gggaaucuacguguguuccaccgcaguugugaaacacacuacuccguguccaggacucau
uucucagaguaguaucauuucgaguuccauccacaccuggggucgggacaca
147 U41465 Sequence below.
ccgggcucgauuucucuagacucgaguuuagaguauucgagcucucccaguuuuuaugcaauauuuuggacugugaugcaa
ggcacuuuggcauacacuacauggccuccccggcugacagcuguauccaguuuucccggcacgcuagugauguucuucucaa
ccuuuaucgccuccggagucaugacaucuugacggacgguugucaucguggugagccgugagcaguuuagaacccauaaaa
cagugcucauggccugcagcggccuguucuacaguaucuucacugaccaguugauaugcuaccuuaguguaaucaaucuag
auccugauaucagcccugagguuguuuugcauccuccuggacuucauguacacaucuaggcucauccugagggaaggcauua
ucaugggcgguggaugaccacagccauguaccuacaaaugaagcauguugucggacacaugcaggaaguucaucaaggccaug
aagcagauauggccccugcacuuuaaccuccccguuagaguuccugaucagccggaugcugaugccccaugacaucauggc
cuaccgaggucgugaggucguggagaucauuaugccacugagauauacucccggguuuugagagcagagcuuuugcuccucc
ucuguacaauggccugucaucaccaccaggccucuuaucccauguacagccaucucccgcucagcaccuuccucuucucugau
gaggagcuccgagaugccccccgaaugccuguggccaacccuuuucccaaggagcgugcccuccccugcgacagugccagg
cuagucccuaaugauuuuuagcaggccagccauggaggugucccccaguuugugucacagcaucaucuacucgcccaauugag
gcagucccagaggaggcucggagugacauacacuacaguguaccugaaugccccauaccugcuaucccuucugcucggaau
gcuccauacuuccccugugacaaagccagcuagaagaagagagaccuucuucggaggaugagauugcccugcauuucgag
ccccccaaugcacccuugauccggaagggucugguuuguccccagaguccccagaaauccgacugccagcccaucucaccca
cagaguccugcagcagcaagaucgccugcauccuucaggccucuggcucuccgccaucaaugccccucugacccgauagc
cugcaucuggaagaaguauaaguucaucguucucaucagccucaaucagaaugccauacccgagggcucugagcaggcaga
gcugggucgccucuccccucgagccuacccugcaccgcccgcuugccagccgccuauggagcccgcgaaccuugaucucca
guccccgaccuagcucagugccaguuugggauugacucuaccaucccccaugccagccggcucaauauucucgugaucaggucc
cuggggaggcuccccccgaugcagcagugagaggucacucaccacucuacaugcaccccccaaaggugcacauccugcauaucuuc
aguccccacagcauacagagaugugccuccauacugcugggcccacguucccggaggagaugggggauacccagucagagu
auucguuauucuauucuguugaauguugaccuucuucugcuacgaaugugacugccguuucucugaggauugccucgcucaag
aggcacacgcugcaggacggcacaggugacauaccauacauauguggaucgcugccaggccuccuuccgcuacaagggcauccucg
ccagccacaagacuguccacacgggugagaaacccuaucgcuguaacauuuguggagcgcaguucauucggccagccaaccu
gaagacccacucucgauuucacucuggagaauagcccuacauaugugauaccuguggguuccagguuuguucagguuugccca
ccuccaugcccacguacucauccacacugggagagaagccguaccccuggugauaucugugggcacucacuuccgggcaccuuca
gacucugaagagccaucugcgcauccacacaggagagaauccuuaccauugugagaaguguaaccugcacuuucgucacaaa
agccaacugcgacuucauuugcgccaguagcacggcgccaucaccaacaccaaggugcauuaccgcgugucggccgcugacc
ugccuccggaacuccccaaaaccugcuaaaugaugcauggaguguuccucgcccuuuccucuccagccccuucucagauuc
uucccauaggaugcuguaacacuuuauacaaaggucaucccaugauguagugccucucucauccacuagugcaaaucauag
uugggguggggguggg
148 U70494 ucgcgauccgacggaggaguaggcacuggaaucucgcugagcguccgccuggccucuacuu
cuuccucgcucgucggagcuucagcacgguccgagauggcuggcgguaaggcuggaaagg
acuccggaaaggccaugacauaggcgguuucccgcucgcagcgagccguucuugcauuuucc
cugugggccguauucaucgacaccuaaaaucuaggacaaccagccacggacguguaggcg
cgaccgccgcuguguacagcgcagccauccuggaguaccucaccgcagagguacuugagu
uggcaggaaaugcuucaaaagacuuaaagguaaagcguaucaccccucuuucacuugcagc
uuacuauacguggagaugaagaauuggauucucugaucaaagcuaccauugcugauggug
gugucaucccacacauccacaaaucgcugaucgggaagaaaggacaacagaagacuguuu
aaggaugccuggauuccuuauuaucucaggacucuaaauauuccuaacagcuguccagug
uuggugauuccaguggacuguaucucugugaaaaacacaauuuugccuuuuuguaauucu
auuugagcaaguuggaggcuuaauuagccuuccaaccaaccaaauuucugcauucgaguc
uuaaccauauuuaaguguuacuguggcuucaaagaagcuauugauucugaaguagugggu
uuugauugaguugacuguuuuuaaaaaacuguuuggauuuuaauugugaugcagaaguu
a
uaguaacaagcauuugguuuuguacagacauuguuuccacucugguggauaagcucaaua
aaggucauaucccaaacuagcuuuaaacuugcuuaauaaucgggucuuaccuuagaucuc
acucagcaacaaguacauucucugcuuacuaauuaaacagugcaucuguagucauaaaaa
aaaaaaaaaaaaaaaaaaaaaaaaaaaaa
149 D17666 Sequence below.
caccaccgugcacgcagcuccgagcccgugagguguuaguucuugcccucguaacccccucuguccagccaccaugauaaa
cgccagcagagccgcggccgcgcgucucgugggcaccgcugcgucccggagccccgcagccgcccguccccaggugagaag
cugccaugccuuccggugggggcuccaggcccggacucgagugaggcaggccuugccuucgggucagacucuaggaaaaa
uccggaugaagggauguaacggaccuucugugggcauuguuggccuucuugcagggcuuuagcuucgaacugugcugag
ucacaauccuuggcguuccuaagucuuuaccccgcuaauugagacgucuguccccccucuaaccugugcgcuuugaaugug
ccuggacuuaggcaguggacguaguuuacuggaaauuuuuuuuuuuuuuuuuuuuuuuuuuuauuuuuuauuuuuuuu
uauuuuauauuuuaauuuuuauuuuuuauuuuuuauuuuuuauuuauuauuuuuuauuuuuacauacuaaggacuaaa
gcuugcauguguuccucagaauaugaaaagcccaaguucuuguguaguugaugacugaugcaacuuuuuuccccccagga
gagaaaaaaaaaaaacacuuauugaaccucaaagcuuggauggguugggugcguuauacauuuguacuuguaguuuauuc
aauaugccacugguaacaccaacauaaaacacaguucuucguauuggagaccacuguucagaugaccauggaauuucauuu
cuuacagaucagaagcaaucaagggugcagugguugguauugauuuggguacuacuaacuccuguguggcuguuauggag
ggcaaacaagcaaaggugagcaugauuggaaaccugaggucacuuagauacccagucuggcauuaauuuacauaggaaugcu
gagucgaagcccagguuagugaugggcacuuuaauccuaguaaagacaaagggaucucugaguucaggaccagccuagag
uauuuauuuuuuuuuuuuuuuuuuuauuuauuuauuuuacuuuaaucagugucuuugggaauuuuagguccuggagaaugcu
gaagguaccagaacuaccccuucugugguugccuuuacagcagauggagaacgacuuguugguauaccagcaaaacggcaa
gcugucaccaauccaaacaauaccuucuaugcuacuaagcgucuuauuggacgacgauaugaugacccugaaguacagaaa
gacacgugaguaauaggaaaaucaguccagaagacuggugcuuugaucaaaguucuguggauaccuugaguucuguggau
caccuugguucacuuuuaucauuauuucugcuugggaagaaaucacaccaccaucauggcauauauuguauuuuuuuauguu
auuucuuuguuguuguuguuuuccuauuuauuuguuuguuuguuuggggggggguuucuuuguguauuuuccuggaac
ucauucuguagaccaggcugguuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuauuuauuuuuuuuu
uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuucaugugauauaugaugaacuuagagugguuaag
uuucacagggauaguuucuuacauaaucuuucugucuuuaaguaagaauguuccuuuuaaaauuguccgugccuccaau
ggugaugcuuggguugaggcucauggaaaacucuauucuccaagucagauuggagcauuuguguugaugaagaugaaaga
gacugcagguaaguggauuuauuucacauuuaggaaaauuggaaugugcuguuuauuucucugcauuaauacugauuaac
uuucauauuucuguagauaaugaagucugaagcuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu
uccugggugcuaaguugcaaggugauagcucagguacucacucuagugucuuucuuggggugcucuuuuccaaggccucu
cuacauauuaagccacaaaguuagucuguugccccucaagauugaugagauguggaauauuauugcuacaguuuuuuuugccuu
augcugugaucacagucccugcuuauuucaaugauucacagcgacagguaaaauuagaucucuuguuugcugggagugga
ggugggguaccugaguuaaaggauggaaagauagauuauuucuacuuucucuauugccacuaaggaugcuggccagauau
cuugggcuuaaaugugcuucgaguugaucaaug-agccuacagcugcuugcucuagcuuugguucuggacaaaucugaagauaaag
uguaaguuggucagaugacguagcauuaccugcauuuacagggguuguguguguguguguguguguguaauuuuacuac
aauuuuuuguggguccguguguugugguacauuuguacauuuguacauggcauguuauauggaugucaaagauuuuuuauu
uuuuuuuuuuuuuuuauuuuuuauuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu
uuuuuuauuuuuuuuuuaaaccaguaguugguguguuacuaauuuuacuuguuucuguaugacaugcuuauaugauacg
uuaacaggcaugccacuuaguuuugauaacuacauucaguuauuaaguauuucaggaaauaucauaguuaauaauuaaacuu
uuggucuuuuuaauucguuccuuuguuuuuguuccuuggaacuuaacuuacuuauuuauuuuuuuagcauucuguguauga
uuuaggugguggaaccuuugacauuucuauccuggaaauucagaaaggaguguuugaggugaaaucuaccaauggggaca
cuuucuuaggaggggaagacuuugaccaagcuuuguugcggcacauugucaaggaguucaagagagagguuaguuaccac
ugcuuagucaccacugguuaagguuguaggcguuggguuguuugagaauuuuuuguuuuguuugcauugcuuuuuagcuuugu
uaauagcuuuuuuauacuaagguaacuaacuauacuucagauucauggguaaacuaaaccaguuuaguuauauaaucuuag
auuugggaacaaaagaccaagugacaguguuauaguagggagaaguuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu
uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuacuacucucucg
cagucuauauaugucuccuaauccuauuuauagacagggguugauuugaccaaagacaacauggcgcuucagaggguucg
ggaagcugcugagaaggcuaaaugugaacuuuccucaucugugcaggugagggauggaaaaaucccaguacugagcauau
uuugaauaguguauucuaauuuaccuaauuuucaguguagcucuuuacaguuuucuguuggcugaaaacuuggguucaugagc
aaaggaacaacuugaugaucaguucuuuucauuugaauugaaugauuagauuauggauguguguauucuuuuugccugcau
gugugucuguacuacauuugugcuugguuucuguggcggccagaagaggguaucagaacugacaugucaguguugggga
uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu
uuuuuuuuuuuauuuuuuuuuuuucacacugaaucuaaauucugaucaugucuuucagucguguuauguuacuuuugagu
gaguaucaaagaucacgucucccaucugacgugugguccugugcagacugacaucaacuugccauaccuuaccauggaugc
uucuggaccaaagcauuugaauaugaagcugacucgagcucaguuugaaggcauugucacagaucuaaucaagagaacuau
uugcuccguugucagaaagcuaugcaggauugcagaagucaacaagagugacauaggagaaguugauucugguuugguggcauga
caaggaugcccaagguauggacucaugguauuucuccuagaggaaaaaaauaacaaugcauucuugaggcaaauggcugu
guuguguguggaaacaaaugugauccauucuucuaguguucuuuaaagaguggugagaccagacucaccaaaaagugcuu
Uuagucaccugugauggcucauguaagaggauggccuugaguucuugauaagaugcaacuuacagaauucuaccuuugcaca
cacacuuaaacccagucugguaaagagaaguuguuaagcuuuuuauuuuuuuuuuuuuuauuuuuuuuuuuuuuuuuuu
uauuuuuuuuuuuuuuuuuuuuuuauuuuuuuuuuuuuuuuuuuuuuauuuauuuuuuuuuuuuuuuuucagauguaaaauuga
uaauacuucuuccuaagauugguucgauuguguagaauaugagaacuguauuuuuauaaccccuugucaugugccuucuauu
ucaaaugauauccucugggaagcuagauaauuaaauucuucucucauuuaaguggacaguggaugagaugcucugaaguu
guaaauacaaacaagucugcagucuuggauaugaaucucucugacuugcugucuggcaggcguauucuguuuggcucca
ucagucgcccuggguguuggcuaacaguuuucuuucucccugaugcuuagguucagcagacuguacaagaucuuuuuggca
aagccccgaguaaagcuuguuaauccugaugaggcuguagccaucggagcugccauccagagagguguguuugacuggugac
guuacagacgugcugcuccuggaugucacuccccucucucuggguauugagacucugggaggcgucuuuaccaaacuuau
uaauaggaacaccacuauuccaaccaaaaagagccagguaagagccauucuuuuuuccugccuauuaacagucccaaguugu
acaauagcuguuuuacaaucacuuuaugaacucuuuaaaacuuuguuucuaagacuauacuaacuggacuagguguuuuuu
uuuuuuuuuuuuuuuauuuauuuauuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu
uuuuuuuuuuuuuuuuuuccuagguauuuucuacugcugcuaauggacaaacucaaguaaagauuaaaggugugucaggg
ggaacgagagauggcuggagacaacaaacuucuaggacaguucacuuugguaaguguuuuugagucugaguaucaugcuu
uuggggucuauagcuugcaaagcuccauacugcugacauuucaggcauauuguguuauuuuuuaaaaagaacguuaugua
caugaguuaugauacccaugauuuuuguuuuuaccuaaagugcuuuguguuuucagaauuugauauuuucaaaucugg
gaaauguucagacucagaagcaaugcuaacucagaaguuaguuuuauccugauuacucauuuuaaaaaacuuaauagcuac
ugguucuggucagcauugcuacaguagagaaguuuauuugcuguaaauucugggcacauauauccaucaugguuuuuaac
uucuuguagcccaguuuauuucauuaaagcacuaauacuaccaccaucacuuauauucucaugguuuugaucauucagugaaga
uacuuguuuuaggaaacaaguauuaguuggccugauuuggaaaugagaauacauaugccuuucaaaggagcucacucua
gauauuuuuuuagauuggauuucccccagccccucguggagugccccagauugaaguuacauuugacauugaugccaau
gggauugugcacguuucugccaaagauaaaggcacuggucgugagcaacaga
150 X14897 Sequence below.
auuuaaaucacugagaacuagagagaaauacuaucgcaaacuguaauagacauuacauccauaaaaguuuccccaguccuua
ccacaagaguaaaacuguucaacaguuaauaguucaaacuaagccauugaaucuaucauuaggaucguuaaaaugaaucuu
ccuacaccuugcaguguaugauuuaacuuuuacagaacacaagccaaguuuaaaaucagcaguagagauauuaaaaugaaaa
gguuugcuaauagaguuacauuaaauacccugauggaaaaaaaaccuaaauaucaaaauaacugauuaaaauucacuugcaa
auuugcacacgaauaugcaacuuguuaaaucaugcaguguuuuauuuaagaaaacauauaucaauacuauuaauauaguuuu
agaggggguaaaauccagguccucugccaggaugcuaaaauuagacuucaggggaauuuugaagucuucaauuuugaaacc
aacauguaggcugcuaccaucacagucauuuuaucaaguucugcucagucaugaacuuauuacaugagagcacgccuauug
cagcaaacacaacuugcugggccacuuuccucccugucgugacacaaucaauccguguacuugguguaucuaaagcgcacg
cugcaccgcggcacugcccggcggguuucugggcggggagcgauccccgcgucgccccccgugaaaccgacagagccugga
cuuucauugagguacagcggcggucuguaggggaucugguuaucuugcagagggaacuugcaucuuaaacuugggcaguucuc
caaaccagagacuaagcuuccccgagcagcgcacuuuggagacguguccggucuacuccggacucgcaucucauuccacuc
ggccauagccuuggcuucccggcgaccucagcguggucacaggggccccccugugcccagggaaauguuucaagcuuuucc
cggagacuacgacuccggcucccguuuguagcucaucacccuccgccgagucucaguaccugucuucuuguggacuccuucgg
caguccacccaccgccgucaccucccaagaguacgccuucucggggaaaugcccggcuccuucgugccaacagucaccgca
aucacaaccagccaggaucuucaguggcucgugcaacccacccucaucucuuccauggcccagucccaggggcagccacugg
ccucccagccuccagcuguugacccuuaugacaugccaguaccagcuacucaaccccaggccugagugccuacagcacugg
cagggcaaauggaaguagugggccuucaaccagcacaaccaccaauggaccugugucugcccguccagccaaagccaggcc
uagaagaccccgagaagagacacuuaccccagaagaagaagaaaagcgaaggguucgcagagagcggaacaagcuggcugca
gcuaagugcaggauccgucggagggagcugacagaucgacuucaggcggauacugaucagcuugaagaggaaaaggcagag
cuggagucggagaucgccgagcugcaaaaauuagaaggaacgccuggaguuuguccugguggcccacaaaccgggcugcaag
auccccuacgaagaggggccggggccaggcccgcuggccgaggugagagauuugccagggucaacauccgcuaaggaagac
ggcuucggcuggcugcugccgcccccuccaccacccccccugcccuuccagagcagccgagacgcaccccccaaccugacgg
cuucucucuuuacacacaguuuaaguucaaguccucggcgaccccuucccuuuguuugcccuucguacacuuccucguuug
uccucaccugcccggaggucuccgcauucgccgggcgcccaacgcaccaauggcagcgaacagccguccgacccgcuaaacuc
gcccucccuucuugcucuguaaacucuuuagacaaacaaaacaaacaaacccgcaaggaacaaggaggaggaagaugaggag
gagaguuggaguuaagcaguccgggguuuguguguguggacccuuugacucuucugucugaccaccugccgccucugccaucg
aucaugacggaaagaccuccuuuguguuuugugcuccgucucugguuuucuaugccccggcaugaccggaggagcugguga
cuuuggggacaggggguggggcggggauggacaccccuccugcauaucuuuguccuguuacuucaacccaacuucugggg
auagauggcuggcuggguggguaggguggggugcaacgcccaccuuuggcgucuugcgugaggcuggaggggaaagggu
gcugaguguggggugcagggugggguugaggucaagcuggcaugcaccuccagagagacccaacgaggaaaugacagcacc
guccuguccuucuuuucccccacccacccauccacccucaagggugcagggugaccaagauagcucuguuuugcucccucg
ggccuuagcugauuaacuuaacauuuccaagagguuacaaccuccuccuggacgaauugagcccccgacugagggaagucg
augcccccuuugggauuucugcuaaccccacuuccucugauuccaaaaugugaaccccuaucuuuacugcucagucuuuccc
ugugcaguauuaugcuaugucccucucacccucacccccaccccaggcgcccuuggccguccucguugggccuuacugguu
uugggcagcagggggcgcugcgacgcccaucuugcuggagcgcuuuauacugugaaugaguggucguuauugcugggugc
accggauaggauugacccccagcccuccaaaacuuucccugggccuccccuucuuccacuugcuuccucccuccccuugaca
gggaguuagacucgaaaggaugaccacgacgcaucccgguggccuucuugcucaggccccagacuuuuucucuuuaagucc
uucgccuuccccagccuaggacgccaacuucuccccacccugggagccccgcauccucucacagaggucgaggcaauuuuca
aagaaguuuucagggcugaagcuuuggcuccccuauccucgauauuugaauccccaaauauuuuuggacuagcauacuua
agagggggcugaguucccacuaucccacuccauccaauuccuucagucccaaagacgaguucugucccuucccuccagcuu
ucaccucgugagaaucccacgagucagauuucuauuuuuuaauauuggggagaugggcccuaccgcccgucccccgugcug
cauggaacauuccauacccuauccugggcccuagguuccaaaccuaaucccaaaccccacccccagcuauuuaucccuuucc
ugguucccaaaaagcacuuauaucuauuauguauaaauaaauauauuauauaugagugugcgugugugugcgugugcgug
cgugcgugcgugcgugcgagcuuccuuguuuucaagugugcuguggaguucaaaaucgcuucuggggauuugagucaga
cuuucuggcugucccuuuuugucaccuuuuuguuauugucucaucuccucuggcuguuggagacagucccggccucuccc
uuuauccuuucucaagucugucucgcucagaccacuuccaacaugucuccacucucaaugacucugaucuccgguuugucu
guuaauucuggauuugucggggacaugcaauuuuacuucuguaaguaagugugacugggugguagauuuuuuacauucu
auaucguugagaauuc
151 AJ006289 Sequence below.
caccugauucccgaaggcccgagcccuuagucuaggcaugguggcgcaugccggaaggacgccaucccuccuaggccau
ggaggcucccgcaccgucccucacggaggaggauuugacugaagugaagaaggacgcuuuagagaauuuacguguuuacc
ugagugagaaaancanagcugagauuacauuuugaucaucuacgugcaaaaaaaauacuaguagagaagacacugaagaaa
uuucuugccgaacuucaaauagaaaacgggcugggaaguuguuagacuacuuacaggagaaccccagaugccuggacaccc
ugguggaauccauccgcagggagaaaacacagagcuuccugauucagaagauaacggaugaggugcuaaagcuucggaaua
uaaaacuggagcaccucaaaggccugaagugcagcagcugugagcccuuugcagccggagccaccaacaaccucucuaggu
gcaauuccgauaagagcaaucucucugagaaacagagagcauccacugucauguaccacccagagauagaguccagcacgg
cucccuucuucucuauggcgucgucccugaacuugccaguccuggaaguuggcaggacugaaaacagcagcuucucuucag
ccacucuuccucgaccuggggacccuggggcucccccuuugcccccagaccuucgguuggaagaggggggaaguugagga
aacucaagugagauguuucuccccuuacggucacgggcucuuucacgccaaugauacaucaccgccuaguuguuuuacuag
ugaugcaaaaugcugugaaggaggccaucuuucuauacaaaccacggugacaggucacucacauucgaugcgugccuuua
aaucaguguacacauucucuguaaauaggauuuguuaggguaaagaagcgcucuggggcggcgugguguaaucauggugg
ucgugacuuuuccauaauguccuuucuuuuuuauuauuuunagguguuugcguauuuunacuuuucauaagauuaauu
uuaucggaauauuucucaauuugagaaaacaacuuguggauugggaauaauguunuuagcacauuuaugcuacaaanuuu
cagucugauuguuuuucccacugaucuggcaguauuuuuagcaguaagcuguugugugucaggaaagcuggacacggga
aagcugccgacacacucagcagugucccacuccunaguucugagaagccgucggguucugaggagacaccugguggcacug
agccuggugaccucaguaggccaaaauuuguuuuuacucacccugccaacgugagugucuuacuuucacaagccuugug
uccucagucuuaucuuaaaggauguuaucuuggcagggcaucacuuguaauuaauggaugauacuuguanuugacuaaag
uccucgcucugagccguuuguucuggcuccgagagcgcugacaugugaagcauggugagcagcgagggaacugacaggau
auggccguauccaguguagcuuuaguauuugcaucaggcagccaccagcuccauccguguucuuacugcuuuacaaaguu
ugacuaacuuuacacauuuuaaaaaugcugauugucuucguuuaaanuauaauuuuaccuauuucuugacaucuaacuccu
auuuauuucuauuauuuaaaaauuaagaaaugaaaauuugcuauuaacaauaaaguuuuuuuaaugu
152 X12944 Sequence below.
gguugggggguuggucagcgccgacguccccugccgccaccaugcccaaaagaaaggcugaaggggaugcuaaaggagacaaa
accaaggugaaggacgagccacagagaagaucugcaagguugucugcuaaaccugcuccuccaaagccagagcccaaaccua
aaaaggccccugcgaagaagggagagaagguacccaaggggaagaaggggaaagcugacgccgggaaggaugcgaauaauc
cugcagaaaauggagaugccaaaacagaccaggcacagaaagcugaaggugcuggagaugccaagugaugugugugcauuu
uugauaacuguguacuucuagugacuguacaguuugaaauacuauuuuuuaucaaguuuuauaaaaaugcagaauuucgu
uuuacuuuuuuuuuuuuaagcuauauuguuagcacacagaacacuucaunacugggugggggaaggaucauguguca
guaacaaaaucucucccaagcuggauugaggacagaaaaccucuuucccugauaauuuuggaaggcuccuguuggcuccca
agagagaaauccugaucuuaaccuagguggccaccaaggcacaacaaugccuuguggucugggaaaacuauaaauucacuu
uuauauccucuucccccuguacuaucaacauagacuuaauucccuuaaaaaccagagaccuguuggaaccuggcccccaaaa
uugguuucccaguccauugagugauggggacuuugcagugacuucauugaguguucucaaaagagcacugguuccuuuua
uaaaaaauuguggaucuucagauugauaauucugccuaaaagucagggucggcuugugaaaaguugunaaaacaacauccu
uaaugugaaaugucaacccucacucuaagcuacuucccccuuuucaaagcauugaaugaagacuucauuggguuuuauagu
ggcuuucugauuuugguagucauaucagaagggaauuuggaaguucuuguauauuguugcauugucugcccauguccug
ccugaauaccaugauuguuuaugaaagaaucuuaauaaagcuaguuacaguuagacuggaaaa
153 AW061302 uuuuuuuuuuuuuuuggaaguccauaaguaguuuauugucuucaagacuacagugugg
auuccucucccagagaagggucuuucagaggcaggggacuuuucacccaggugcaggccgu
cuacuugucauuuucauacauaucuggauucuuccuuuucgacugcucaaacuccuauuu
gccccauguguagaucagguagaccacuacaaacggcggcgccacgcgcaggaugcgcuc
gcgagugcggcgcaacacuuuuggggaugccuuugcugaaauagcuugggaaggcgcgcug
cucaaagggcgacaagcugua
154 U67328 Sequence below.
caugaagccagagauguggaagaugugucuagacugcaucaaugaacugauggauacguuggaugcacauuccaacaucuc
ugucggagagaacauuuuggcagagagugagaacuuacacaacuuugaucaguucacuccguguacgacgcugcauccuaa
cuuugguggagcgaauauaugaagaauuuaccaaaauaaugcaaaauacugauccucacucccaaaaguauguggagcacc
ugaaggaugaggcacaagugugugcaucauugagcgagugcagcgcuaccuggaggagaaagguaccacugaggagaucu
gccagaucuacuuaaggcgcauccugcacacguacuacaaguuugacuacaaggcccaucagcggcacguuacuccuccuuua
aggauccucaaagucugagcaagaccaggcagaaaaugagggugaggacucagcugugcuaauggaaagacugugcaagua
caucuaugccaaggaccguacagaccggauccguaccugugccauccucugccauaucuaccaucaugcgcuccacucccgc
ugguaucaggcccgugaccucaugcucaugagccaccuacaggacaacauucagcacgcagacccgccggugcagauccug
uauaaccguacuaugguacaacugggcaucugugcuuuccgccaaggccugacaaaggaugcacacaauggcacuucugga
auucagucaagugguggugccaaggagcuucuaggucaggguuugcugcugcgcgcuugcaggagcgaaaucaggaaca
ggaaaagguagagcgacgccggcaggugcccunucaccugcacaucaaccuggagcugcuggagugugucuaucuggugu
caacuaugcuccuggagauccccuacauggcuacccaugagagcgaugcccgccgacgcaunaucagcaagcaguuccacca
ccaacugcgggugggcgagcggcacgcccugcuagguccucccgagucaaugagggagcaugugg-ucgcugccuccaaggc
caugaagaugggcgacuggaagaccugccacaguuucaucauuaaugaaaagaugaaugggaaagugugggaccuuuuccc
ugaggcugacaaaguucgcaccaugcuaguucggaagauccaggaagagucucugaggaccuaccuuuuuaccuacagcag
ugucuaugacucaaucaguauggagacacuaucagauauguuugagcuggaucuacccacuguucacuccaucaucagcaa
gaugaucauuaacgaagaauugauggcuucccuggaccagccgacacagacuguggugaugcaccguacugagcccucugc
ccagcaagaaacuuggcucugcaagcuggcungaaaacuuggcacccuaguggagaauaauggaugguguuugaccaaa
aacagggaaccuaugguggcua-uuuccgagaccccaaggguggcuaccggaaaaauggaggcuaaaugccccgugguggcu
acccccagcaacagucucagacaaccuccugaguuccccacuucagucacccuguggacagaccaucuaaccuuuuucuccu
aacucaccccaaucauuaaagaucuuuugaggaauuaaaaaaaaagaaagaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
aaaaaaaaaaaaaaa
155 AI604314 uuauuaauuaaaaaacaauuuauugaaaaagaguagugcuuuguacaaauucccauugca
gcccccagauaucaacugaucucuuuccagcuuugguaguaggguauaaaaauaucaaaa
cuagguaaguucugauguaagauuucuaugagauuauuauagaauauauagauuugugua
guuuggcaaguaucauuucuaugcauuuacauuacauauuaagcacagauucuguggcaa
aacaucuuugcauganuacuuuacacacacaaauauaguaaancuuacauaguacaaauu
cacauaagacuccauucugucuauaaucauccaugugguuuuaccaugaauuaana
cuuaaccucuccuauaacucagcuuccauuuaauuuugaaaguaucacuucacaaaga
gacuucauuugcuuuuauuauacauagacu
156 AI845121 cggccgccaagaaguauaacaugcgaguggaagacuacgagccauaccccgaugauggca
uggggunggcgacuacccgaugcuccccaaccgaucacagcaugagagggauccguggu
aucagugggaccacucagaacucaggaugaacuggggngaaccgauacacugagaccuag
acauguacaucaggaaucguguggacacgucaccaccccuguguccugngaugucaugu
guaaacaucucuucggcnnuguggcnuucaugguuuucauguucuggguagggcacgugu
ucccuuccuaccugccugugaguccgaagcaguacccuuacaaaaaucuguaccuggagc
g
157 AW047756 uuauuuunuuauuunuugaugcaaaugucuuuaunuuccacuuaaacaaguuucccuuuu
gcacuggccuguggcacaaaacagauggcuggguggugacauuaacugucaaguuaguga
gaugcagagauggugagacacugcauuugagugcauaauacuuuuauuccagaggaacgc
caugcagcccaguuacaccuuuagaucagaaaggcugaugcaugaccagccucuauugcc
ucccuugguaagaaggacccacaagugcagaguccaacagaugcuggcucugagcugaac
ucagggcauuccaauuaccacuuucuucuucaccuacacagggccugcucagauguccuu
uuuacaacuccauaagcccuuggccaaagucccugcaguguuuggggaggaccuuccca
cccuucaccagucagugucugaucugguggag
158 AI838021 uuuuuuuuuuuuuuuuuaauaucuguaauaguuuanuucaaagauuugacauuuacaag
agaggcaccacaugcuaucugacaguaaaauacugcagggacugaaggccaaggagagag
auccacagaagacaggccuguagugcaggcauugcaucgaccuugcccacagugcnuugu
ucccaacucaggacaguacuuuagugcnugcuucauuacuggaaaaguucacuggacau
aguunccacuuncccccacagcuuccagcucagcaaacuuaagcuacuacuccucgau
gcucucauagaggcucuugauuugugucuggaagaacuuggcaagcucuacucguuuggc
uuucagugucggugucagnaguccguuacaa
159 AW122893 uuuuuuuuuuuuuuuucugaggnauuaaaauaucuagacugaauuuugccaaauguaag
agggagaaagnaccugaagacucugacuacuugcuuanuuuugauugaccuucuugcuu
augucauuacugccucacaacgngunugauguccuuuaaugauacaaagugagccgugc
cuucauuuucuugcccauuuugguaccccucaugccg
160 M59821 Sequence below.
gcgcccgaacgucuagcagaguaccuacugcuguaagcnugucgucugggcugcaccgcccgucuuaacccauucucgacu
uaacuacucucgucgaacaagcauggaaguacagaaagaagcgcagcgcaucaugacucugucgguauggaagauguacca
cucucgcaugcagcgagguggcuugcgacuccaccggagucugcngcuaucccucguuaugcgcagcgcucgagagcucua
ccucucagccaagguagaagcccaccagcccgaguucccgccaucccgcagggcucuugacccucgccugcacccgccgcag
gaagccgaaguugcaguggaaguagcgucccccgaagccgugcagccuccggagcccauggauacgcaagaggaagugcug
cgaguccaggagaccccugcgcucugugacccgccccccgcuagagucagccuaagcgccggagcagcagcguuuugagc
gacaguagugaugccggacugguaccaagcaagaaggcccgucuagaagagguggagggggaggcgacgucggagguucc
caaucgccugcagcuuccuccggcacaaagcgaaagugccuucccuaaccucgcccgcguccuccaaaggcgcuucuccaau
cuccugaacuguggacccgccgugcccccgccgacgccccccacgugcgaggccaagccagccugccgcccggccgacaaua
ugcucaacgugcuggugcgagcugugguggccuucugagagcucugguggcuucuuucgagcggcgccaccggagcggag
aacuucacacccgaggcgaagucggcgggggccgugaagaagagccgaugcccgagcuucgagaggccagggcaaggacu
gaggagcgaggggcgcgggcgccuucucccagacgugcguccauaggugcuauuaaaggacugucccuuccuuggcuugg
agaagggacaccuagaucuugaaucucagggucgaacucucuaggggccaggcugcccuuucaaggccguuucacuaccau
ucgcguuucggccccuacaagugggcacgcuugugcaagcggucagaguugcgucaugggacagacgcgggugcuuccug
uugccucugcguggguguggggccuaggaagaggccaggguguggacccgcccuagggacugggaagugacuugagucac
cucgcccccacaggcugcugugggugagccugaacugaaccaaucaaaucugcgcagaguugaaguggcuggagaccccgg
gacuguuucaaccuagaugaucgccuggcguggaccaccgauggacgggcuuggccgcuggucguaguuuugccguagaca
caacuucuucaggcaggaaagaaaauuuuuuucuaccagcguguuuaagaaagucuguuuacuuuucccacgguauguu
guuuaauuagcaacuaccuggaguucuacaaugucagcuaggaaaauaaagaccaucggugu
161 M13805 See above (same Accession Number).
162 A1845886 uuuuuuuuuuuuuuuuugguuccacuuaaguugcauguuuuauuucucccaaucccagc
a
auagcacagaagcccaucauguccaucccagacugguuucuaguaggcugagaugacagg
gagccucaguaacgcuaauggcacagagggcucccaaaugccaggcacaacugugccucc
acacuggugacugcccagagugcccuugccccaguguguuggcacucagucugacuuac
aacgcaaccugcaccuuugaaagggacagucugggaguggggagugugagggagugaagc
ucaaacugccuccugucagcucacccuuucaacauuaaacagagaccaagagagaaacag
uuccaauauuucacauauauuucuucuugugcagucuaaucgagaaugccauguaaaug
gucacuguucgaaaugcagcaauuuagu
163 X53157 gucucggugagauguuucaagguuacuucgcggagugggcuuuuggcgugcaggcc
cugaggcgcacggcccguggcgcggccgugacccgcuccauggcuucuggaggugguguc
cccacugaugaggagcaggcuacugggcuggagagggagaucaugauagcagcacagaag
ggacuggacccauacaauaugcuaccuccaaaggcagcuucaggcaccaaggaagacccu
aaucuagucccguccaucagcaacaagagaauagugggcugcaucugugaagaggacaac
uguacugucaucugguuuuggcugcacaaaggcgagagucagcgaugccccaacugugga
acccauuacaagcuggugccccaccaaauggcccacugagccccuguguuaucuuuucag
aauguaaagaaaaacuucucucuaauaaagacuagccauugcaccugcuccuccc
164 U19118 See above (same Accession Number).
165 AF062071 Sequence below.
gcgcaccgccuggguggcgcgccagcgucgucuaggugcaucgcgggcccccgcaguuagaaaaauauggcucaggagacu
aaccanccccagggcccaugcuguguaguacaggauguguuuuuaugguauccuaggacaaauggaauguguucugu
uugcuacaaagaacaucuucagagacagcagaauaauggcagaauugagcccaauauggacagcuaaugguuccaacagucc
uaccucagauucugcaucuguacagagagcagaugcugguuuaaacaacugugaaggugcugcuggcagcacaucugaaaa
aucaagaaaugugccuguggcugccuugccuguaacucaacaaaugacagaaaugagcauuucaagagaggacaaaauaac
uaccccgaaaacagaagugucagagccaguugucacucagcccaguccauucaguuucucagcccaguucuuucucaaaguga
agaaaaagcuccugaguugcccaaaccaaagaagaacagauguuuuauguguagaaagaaaguuggccuuacaggguuuga
cugccgauguggaaauuuguuuuguggacuucaccguuacucugacaagcacaacuguccauaugauuacaaagcagaagc
ugcagcaaaaaucagaaaagaaaauccaguuguuuguguugaaaaaauccagagaauauuaaaauuacuacaugugaagagac
ugaaacuuuguuuuuauuuuaauauaucguaggaaaacauuaaagagcagaugcauggccauuuuccuuugauguucucc
agaguuuugcuuuauacuugucugucauauaauugaucuuuuaggauguuuggguguuuguuacaggcagaauuggaua
gauacagcccuacaaauguauaugcccuccccucaguaaaauuggacaaaaauaugcacaacaaauuaaaauacacauauac
uaaucaagguauaaucuuuggcuaguguuaugugccuguacuuaaaaaaaaaaaaaugguacaccagaaaaggacuggca
gucuacuaccauagucaaacuucaccuuaauuucgacaugacuuuuggaagcaggaagaaugcuacaaaacugguauuugg
uaccaugugugagccugguuaaauuggucuucuaaaagcugucaauuaggacauucugcgaaagguaacaucacuacuggu
ucuaagucaaaccaucaagucaacagcagggugccugagauaaucuuggaagcuuauugugcuggccugcaccagaagaua
ucugcauucucauucuaauauauguagcacagaacugcacuaggauuuguuuacaaguuagaaauuaaacucuuuuuugguu
uucacauauagcagcucuguuaaauaacaugcaucugauuuuuauugcaaagguaucuaaacaauuaauuuuucaugu
gcaucuuuuguugaauguuuugguucaagaaagaauguuuaaagcunuuuaaagacuucaguucuuaauguaacuguacc
cuucuuucauggaaaaucauaaccaacauggcugcaguauuacuucuuuaguuuguauccagcaccacuugcagagggcugcuu
uaucauauuguacuuggguguaggacucuaguguucuuggguguauugcauaggcuacauuaucuacaacauuguacaa
uaacanuagaaaaggcgguauacuucacugaugcuugucugguaauaucacuucuguguuaaaauggaagguuuuuugu
gauguaugaaacuuguguuuuuuauauauaaaugaguauaguuuuauuaguguugugguaaugccuguuuucaucugua
aauaguuaaguauguacacaacaaggcacuacuucugauuuuugcaguguucaguccuaguuuuucuuuuuaaaacauu
gaguuugcuucaauuuuauguaccuuaguucuaaguuagauuugcagauguguacagauaguucauauuuauguauug
cacauaaucaugcuauucagcauugaugcuauauuguauuauguaaauaauaaaagcaguguacagagggaaaa
166 U10404 augacaggaugccgcuguguccuucgccaaggacuucuuauccaguggaguggccgcagcc
aucuccaagacagcgguagcacccaucgagagggucaagcugcugcugcaggugcagcau
gccagcaagcaaaucacguauauaagcaauacaagggcaucauagacugcuugguucgu
auccccaaaganagggaauccuguccuucuggcgugggaaccuauccaaugucaucaga
uacuuccccacccaggcucucaacuuugccuucaaagauaaauacaagcagaucuuucug
ggugguguggacaagaggacccaguucuggcgcuacuuugcagggaaccuggcaucaggu
ggugccgcuauggcuacauccuugugcuuuguguacccucuugauuugcccguacccg
u
cuagcagcugaugugggcaaagcuggagcugaaagggaauucaaaggccuuggugacugc
cugguuaagaucuacauaucugaugggauuaugggccuguaccaaggcuuuaauguguca
guacagggcauuaucaucuaccgagcugccuacuuugguaucuaugacacugcaaaggga
augcucccagaucccaagaauacucacaucuucaucagcuggaugauugcacagucuguc
acugcugucgcuggccugacuuccuauccuuuugacacgguucucuuucguaugaugaug
cagucuggacgcaaagganugauaucauguacacaggcacgcuugacugcuggcggaag
aucgcgcgcgaugaagggagcaaggcuuuuuucaagggcgcaugguccanguucucaga
guuauggguggcgccuuugugcuugucuuguauguugagaucaagaaauacacauua
167 U07634 Sequence below.
cguagaaguugucucugucggcgggcgggcgggcaggaguggggcaccgagaccggcgugcggacagcagggaucgcggg
gagcgaggggugcngcauggagcuccgggcagucgguuucugccuggcgcugcugugguuugcgcgcuggcggccgcg
acggcacagauaaggaaguuguuuuguuggacuucgcagcaauaaaaggagagcucggcuggcucacgcaccccuaugg
cuaagggugggaccugaugcaganaucauggacgacaugccuaucuacauguacucggugugcangugguauccggcga
ccaggacaacuggcuccgcaccaacuggguguaccgggaggaggccgagcgcaucuuuauugagcucaaguucacggugcg
agacuguaacagcuucccggguggcgcccaugccugcaaagagaccuucaaccucuacuaugcagagucagauguggacua
uggcaccauuccagaagcgccaguucaccaagauugacaccaucgccccugacgagaucacggucagcagugacuucgag
gcucgcaacgucaagcugaacguagaggagcgcaugguggggccccuuacccggaaguucuucuaccuggccuuccaggac
aucggcgccugcguuucggcugcucuccguucgcgucuacuacaugaugugucccgagaugcugcagagcuuggccuucuu
ccccuugaccauugcugucgcugunuccgauacacaaccccuggccacgguggccgguaccugcguggaccaugccguggu
gccuuaugggaucgagggggcucucaugcacugcacgguauauggcgaguggcuggugccauccgagugccugugccagg
aaggcuacgagaaggucgaggaugccugccgagccuguucuccaggauucuucaagucugaggcaucugagagcccuuccc
uggaguguccagagcauacccugccauccacagagggugccaccuccugccagugugaagaaggcuauuncagggcaccug
aggacccacuguccaugucuugcacacguccacccucugccccuaacuaccucacguucaugcauggguuuccaaaguagaacu
gcguuggacagcucccaaggacacugguggccgccaggacaungucuacagugucacuugugaacagugcugcgcagaguc
uggcgagugugggcccugugaggccacggugcgcuanucagaaccuccucacgcccugacccgcacgagugugacagucag
ugaccuggagccccacaugaacuauaccuucgcugucgangcacgcaauguucgucucaggccuggugacuagccgaagcuu
ccagacugccagcgucaguauuaaccaaacagagccccccaaaguaaggcuggaggaccgaagcaccaccucccugaguguc
accaggagcaucccggugucacagcagagccguguguggaaguacgaagucaccuaccgcaagaagggggangccaacagc
uauaauggccgccgcacggaaggcuucuccuuugacccuggaugaccuugcuccgganaccacuuuaccuggugcaggugcag
acauggacgcaggagggccaaggagccggcagcaaagugcacgaguuccagacgcuguccacggaaauaucucgcaacaug
gcggugaucggcgguguggcuguagguguugunuugcuucugguacuggcaggaguuggccucuucauccaucgaagga
ggaggaaccugcgggcucgccaguccucugaguuauguccguunauccaagucagaacaacuanagccccugaagaccuaug
uggauccucacacuuncgaagaccccaaccaggcuguacucauuuuaccaccgaaauccacccauccuguguggcaaggca
gaaggucauuggagcaggagaguuuggagaggucuauaaagggacgcugnaggcauccucggggaagaaggagauaccgg
uggccaucaagacacugaaagcgugcuacacugagaagcagcggguggacuuccugagcgaggccagcaucauuggccagu
uuagccaccacaauaucauccgccuagaggcgguauucucuaaauacaaacccaugauaauuaucacagaguacauggaga
auggagcgcuagacaaguuccuuagggagnaggauggugaguucagcguacuucaguuggugggcaugcugagggguauc
gcauccggcaugaagnaccuggccaacaugaacuacgugcacagagaccuggcugcccgcaacauccucgucaacagcaacc
ugguguuucaagguuuuccgauuuuggccugucgauugugcuggaggauuuaccccgauugccaccuacaccacaaguggcguuc
aagaucccuauucgauggacagccccagaggccauuuccuaccgcaaguucaccucagccagcgauguguggagcuacggc
auugucaugugggaagugaugacuuauggcgaacggcccunacuggaacugucaaaccacgaggucaugaaagccaucaac
gacggcuuccggcuccccacgcccauuugacugcccuucagccauuuaccagcucaugaugcagugcuggcagcaugagcgc
ucccaccggcccaaguuugccgacaucguuagcauccuggacaagcucauccgacgccccgacucccucaagacgcuggcug
acuucgauccccgaguguccauccggcugcccagcaccagcggcucggagggaguccccuuccguacuuguguccgaguggc
uggauuagcaucaagaucgaacaguacacggancacuucauggugguggcuacacggccaucgagaagguguuuacagaug
ccaacgaagacaucaaaaauaucggaangcgucuuccuggccaccagaaacgcauugccuacagccugcugggacucaagg
accaggucaacacaguggggauuccuaucugaguccaunggggcugucacacaauacungaagagccacaguggucucccu
gccgaucugguuucuggcccacuggaacuuuauuuauuucuguuuccucuuucuaugccucccuaggacucugcagguugcuu
uuuaaaugacaccugccuaagccugauaaacuuggauugcuagucagggcucucuuuccccugaaaaauacccagcuaaga
acuuagcagunugccauggccuucccagcauccccugaggcuaaaguuccaccaagagucganaucgacgagggacauuuc
caaacggaccuccccaucuncanuuggccuccugagaagccacucuggagcugaggcnaagcacuaagcccaggaccauaug
acuagcacuguaccgcccgccccuaguuagaagguaaguuuuauacuuggcuggguuguggucacaagcaaucucccaan
gccuuuuncagaccccagucugcccucccgucgagggccagcuucuugcuuuccuagggcccucucaggaugcuuggcug
ugcugagguuunuauuaaauanauauuuuauacuugcggaaagaaugaguguguggcagggacuugccagggcuggagac
agaggauccccugcaucaagacauucccgguucugguuggcuuugcggaccugcaggagacuuuccgccaccaccccgucucca
gccccuuuggacaaaugucgcugucaguguuncagauuucuuuuauugggauguuunuuuguuguauunuuuugaaccu
uaacuuanuaunuuuuuuauanuuaunguuagaaaangacuuanuucugcucuggaauaaaguugcagaugguuca
168 X04663 Sequence below.
ccaaaaaccuuuuuuncuuucuuguncgguaccuacanuggaaccaccauaaacaauuauuucauuuuaccguagccauuua
aggaaaucgugcacauccaggccggacaguguucaaccagaucauugcuaaanucuaggaauucauaagcgaugaacaug
gcaucgaccccaccgguaccuaccacggugacagcgaccugcagcuggaccgaaucucuguguacuauaaugnagccacagg
uggcaagnaugucccucgagcuaucuugguggaucuagaaccugggacuauggacuccguucgcncagguccuuuuggcc
aaaucuucagaccagacaacuucguuuucggucagucuagggcaggcaacaacugggcuaaaggccacuacacaaaggaag
cugaguuggu-ugacucugucuuggauguggugcggaaggaggcggagagcugugauugccugcaaggcuuucagcugac
ccacucacuggguggaggcacuggcucuggcaugggcacccugcncancagcaagauccgggaagaauauccugaccguau
caugaauaccuucaguguggugcccucgcccaaagucucuuuauaccguggucgagcccuacanugccacccugucugucca
caccacgccaaccuacggagaccugaaccaucucgucucggccaccaugagcggcgucaccaccugccuccguuucccgggc
cagcuuaaugcugaccuucgaaagcuggcugucancauggugccnuucccacgucuccacuucuucaugccuuugcuuugcc
ccucucaccaaccauggaagccaacaguaccgaucccucacugugccugaacuuacccagcaauucuucgaugccaagaaca
ugauggccgccugcgacccgcgccacggccggnaccucacaguugccgccgucuuccguggacggauguccaugaaggagg
uggaugagcagaugcucaacgugcagaacaagaauagcagcuacuucguggaauggauccccaacaaugucaagacagcug
ucuguaacaucccaccgcguggccucaagauaucaaucaccuucauuggaaacagcacagccauccaggaacuguucaagc
gcaucucugagcaguuuacggcuauguuccgccggaaggcuuuccuccacugguacacgggugagggcauggacgagaug
gaguucaccgaggcuuuagagcnacaugaacgaccuuugugucugaguaccagcauuuaccaggaugccaccgcggangagna
aaggauuucggaaaggaggcagaagaggaagccuaacucagugagcccugcaucagcucaggcugcuuagaucccucaac
cuuucuccaacugcccuuuguccuccaguuucuuucugcugccucugucuuguauuuguuuugcuucuguuuucucauu
ggggguaaauggugccuggcacauggcaggcacucaauaaauauuuguuugugg
169 X61232 Sequence below.
ggcagacaaaagaggccggcagugcagcucgcgggacgcauggccgggcgcggaggacgggugcugcuggcgcugugugc
cgcgcugguggccggcggguggcugcugacgcgugaagcccaggagcccggggcgccagcggcuggcaugaggcgccgcc
ggcggcuccagcaagaggacggcaucuccuucgaguaccaccgcuauccagagcngcgcgaggcgcuggugucgguauggc
ugcagugcaccgccaucagcaganucuacacagugguucgccagcuucgauuggccgggagcuccuuugucnucngcugucug
acaaccccgggguccaugaaccgggugaaccugaauuuaaauacaucgggaacaugcauggcaaugaggcgguuggacggg
aauugcucauuuucuuggcccagnaccuguguaacgaguaccagaaaggcaaugagacaauugucaaccugauccacagca
cccgaauucauaucaugcccuccuugaaccccgacggcuuugaganagccgcauggcagcccgguucagcugaagncuggu
uugugggccgcagcaacgcccagggaauagaucugaaccguaacuucccagaccuggacaauaucguauauguuaaugaga
aagaaggcggucccaacaaccaccugcugaagaaucugaagaaaauuguggaccaaaauucaaagcuugcccccgagaccaa
ggcuuucauucacuggaucauuugacauuccauuugugcuuucugccaaucugcaugaggagaccuuguggcuanuucc
cauaugauaagacacggagcauuacugcucacgaauacaauuccugcccugaugacacaauuuuccaaagcuuggcucgcg
cguacucuucuuucaacccagucaugucugaccccaaucgaccucccugcugcaagaaugacgaugacagcagcuuugaug
auggaacgaccaaugguggugcaugguacagcguccccgguuugaaugcaagacuucaauunccugauucagcagcaacugcu
uugugaucacuguagagcuuacgugugagaaguucccaccuaaagagacucucaaaagcuacuggguaaauaacaaaaacu
cccucaucaacuaccuggagcagauacaccgagguguuaaaggguuuguccgugaccuucaggguaacccgaaugccaacg
caaccaucucuguggaugggauagaccaugaugucaccucggcuaaggauggggauuacuggcgaungcuugcuccugga
aacuauaaacuuacagccuccgauccuggcuaccuggcaaucacaaagaaaguggcaguuccuuuuagcccugcuguuggg
guggacuuugagcuugagucuuucucugaaaggaaggaggaggagaaggaagaauugauggagugguggaaaaugauguc
agaaacuuugaanuuuuaagaaaggcuncuaacuaauugcuuucaucuaucuauagacuguaguaagaugcaauguggcn
cuuuuucuuuuagguuguuuugcaguugauauuuancauugauuuuuuuugaucauuaaguaauaguuncuaaucacguaa
auacacccggacaaaaauauaaugcuggacaucuucauucuacaucaacauucgcuuaaaucauucaaaaccucuuuuaacg
naaugggugacaaugucacuugacagangcaugagagucacgauauagcugacugugacccugcacugcaaucacauaguu
ccauauaaguuguccuuagucucuuguuucugauucacuguauaagcaugauccuuuguanugcacuuuggaugggaagaaa
auguacgugcuuuucagaauggcucugaacagaaugguaaaccuaguucuugcguguacuuuaaaaaauggaauuguauua
gucagcuguuaaugccacuucagaaguuugggguuuugucuugauuguagauugg
170 X14309 Sequence below.
gccacggacgccucucugaacggggauccaguucauugauuagagcugccucacugacuacaggccgugucgugucaccguuu
Cugcaggcaccaugagccaggacaccgaaguggacaugaaagauguggagcugaacgagcuagaaccggagaagcagccca
ggggucauguucaccggcuuauccnauugaggagcuacugaagguagcguugcagcccuggcugguuugcgcacccgcugggc
gcugcuacugcucuucuaucucgguuugacuugaucaugcuggcgaucgccguanuuaucaucguucgggcgccgcgcugc
cgugagcugccuguacagaggugguggcacaagggcgcccucuaccgcaucggcgaccuucaggccuuuguaggccgua
ugcguugaguucauagcuggucuguagagccaucuggauuuacuugagcacccugaaggugaagggccugguguuaggcccaa
Unucacaagaaccagaaggaugaaaucaauugaaaccgaccugaaacagauuaaucccacuuuaugcucccagguaaauuuuaa
agaccuucuacaaagugccaagaaaaagagcauucacaucauunuggaccucacucccaacuaccagggccagaaugcgugg
nuccucccugcucaggcugacanuguagccaccaaaauguaggaagcucugaguncuuggcugcaggacgguguggaugg
Uuuccaauuccaggauaugggaaagcugauugaaugcacccuuguacuuagcuguguggcaaaauaucaccaagaacuuaag
ugaggacaggcuuuugauugcagggacugaguccucugaccugcagcaaauugucaacauacuugaauccaccagcgaccu
gcuguugaccagcuccuaccugucaaauuccacuuncacuggggagcguacugaaucccuagucacuagguuuungaaugc
cacuggcagccaauggugcagcuuggaguuguaucgcaagcaggacuuccucgcagacuuuuauaccggaccaucuuucuccgacu
cuaccagcugcugcucuucacucugccagggacuccuguuuuuagcuacggggaugagcuuggccuucagggugcccuuc
cuggacagccugcgaaggccccacucaugccguggaaugaguccagcaucuuucacaucccaagaccuguaagccucaacau
gacagugaagggccagaaugaagacccuggcucccuccuuacccaguuccuugcggcugagugaccuucgguuguaaggagcg
cucucuguugcacggugacuuccaugcacugucuuccucaccugaccucuucuccuacauacgacacugggaccagaauga
gcguuaccugguggugcucaacuuccgagauucgggccggucagccaggcuaggggccuccaaccucccugcuggcauaag
ccugccagccagcgcuaaacuuuugcuuaguaccgacauuugcccguucaaagccuuugaguuaggacaccucccugauuucugga
aaaccugagccugaauccuuauguaugcuugcuguuacaguuccccuuuguggccugauuccuuccuaugcagaaccuacca
cccuccuuuguucuccccaggccuuuuggauucuagucuuccucuccuuguuuuuaaacuuuugcagaunacauacgaau
ucuuauncuggguguuuuugucuucaaauaaaaacaucaccccugccucaug
171 U42386 Sequence below.
ancuuaaaccncguuuauuuugauanccuguuugacuucagunaugnccaagaugccnauuguuuuuugcccnaaauaaauuu
acugaacuugggcuaaaaccaaaccuuggcacacaggugugauacaacuuaacaggaaucaucgauucauccauaaauaaua
uaaggaaaaacucaagugguagccugucuuaaggcuuuugauacuugcagauuggggaaaaacaaacaacaaacgucuuga
agcauauuaauggaauuaguuucuuaauuguagcaaacuguauuaaguuaaaaguucuguunuacuucacucuauccuggaua
gguauuuagaaccugauaauagucuuuaaacaagccauuccagucaugaugaggugauguauggauacaugcauacauuca
angcacuguucucaaaguuaaugcauguaaauacagcaauuccucuuucaauguuuaggcagaucguuaacuaugagcuag
ccaaaugugggcauguunuuacagggaaaguuuaaaggucugauaacuugaaauagguuuaggagaauucaucuacuuag
acuuuuuaaauugccugccauaaaaaauugaaaugguagaauggcugaccacagcaaugaccagcccucaccuaaugcucug
gaugaunuuuggucuanuaacgcaugcuaguguugauguuuuuuggucaagaugggaaugaacaggaagaauuangcagc
aggcuuuuuuuaaaugccgauucacauuacucuguucaagcugcguugagauuuuuaaacuggcuuacuauagacuuuuu
aaaaaaaaaaaaaaccaaacaaauggcuccagaagaguaacaaacugaaaucugagaucacacagguuugguaauauguacaua
acugaacaaggugucaauucugcucuacagugcaguuuagucaguuuunguugcanaggunuccauuguuuuuauagucu
ggnuaugcuaaaucuggccaaagaugagcauuguccaccacuaaaaugccuaugccacuuuggaauucuggguuaauuuug
uugaccagaaugcagaucaaaauguucaaucuuuuuacaguggcauaagaagauaucaaaaauuuccuaaagugcaauag
auuucauguguauuugugccuuguucuaaaacuuuuauuaaguaggugcacuugacaguauugaggucauuuguuaugg
ugcuauuucaauuagucuagguuuaggcccuuguacauuuggcccauaacuuuuuacaaaguacuucuuuuuugcacau
uucagagaauuuuuauauauuaugucuugugugcguguccuuaaacuuccaaucuuauuuuugucucuuuggagauuguuugaacg
cagcuugucuaggaaagggaugggacuagauucuaaaauuuanuugggaccaugggaaugauaguugggaagaaacuuug
cacacgacagauuucuagauacuuuuugcugcuaguuuuauguaauauuuauugaacauuuugacaaauauuuauuuuug
uaagccuaaaagugauucuuugaaaguuuaaagaaacuugaccaaaagacaguacaaaaacacuggcacuugaauguugaa
uuaagcagacccggcauuggcguguagccauaacuuucugauguuaguaaaaacaaaauuggcgacuugaaacuaaaucau
gccaagguuugauacacuugucuugagauauuaacgaaacacuuccaaacacugauacaaaguguccagauucucagaugu
uuguugugugaguuuuguuuaguuguauuuuuuuuucagugaaugucuggcacauugcaauccucaaacaugugguuau
cuuuguuguauuggcauauucagugacuuguacauucagcaauagcauuugagcaaguuuaucagcaagcaauauuuuc
aguuuauguuuccaaauuaagaauggguuuaaacuugcugaauguaaauuauugacccucaagucacuguagcuuuaguagu
ugcuuauuguauuaguuuagaugcuagcacugcaugugcugugcauauucuaguuuuauuaaauaaaaaguugaacuac
acagucuccuuuguuguugucaauugugguuuacuuuuagaggugaaaauaaaguugugcucuugccucgugccaauaug
uacauaacugnacaauugugucaauncuuucucuacagnuunaguuuagncauuuuuagungnauaguuuucccaunguuuuaua
ungncuguuuaugcuaaaucuggccaaagaugagcauugcccaccacuaaaaugccuaugccacugggaauccuagguuan
uuuggngaccagaaugaagugancaaaauguccanucuuuuuacaguggnauaggaagauggnaaaaauunccuaaagug
naauagauuuccaaguguuungugccugguncuaaaacuuuunuuaaguaguugugcacunganaguauugauugncauug
auuauggugcuauuuccanuuagucuagguuuagacccu
172 U51126 Sequence below.
g
gacuaugggcaucuggguucuuccucuucuacuuggccacgagguaaccggcuucuuguaccacgugugcucaccucuac
aaucugugcggauucagacuccaagcaacuaggcuacccagugacaggcuaaaaacuacagcucuaacgucuuggaaggcg
auuccauggaccaggauguggaaagcccaguggccauucaccagccaaaguugccuaagcaggccagggacgaccugccga
gacacaucagccgagacaggaccaaaaggaaaauccagagguacgugaggaaggaugggaagugcaacguucaccacggcaa
ugugcgggagacguaccgauaccugacggacaucuucaccacccugguuugaccugaaguggagauucaaccuguugaucuu
ugucauggucuacacagugacguagcuuuucuuugggaugaucugguagcugauugcguacauccagggagauauggac
cacauagaggaccccucguggacuccuugugucaccaaccucaacggguuugucucugcuuuuuauucuccauagagaca
gaaaccaccaucgguuauggcuaccgggucaucacggacaaguuucccugaggggauuauucuccucuuaauccaguccgug
uugagguccauugucaacgccuucaugguaggauguauguuuaugaaaauaucccaacccaagaagagggcagagacccug
gucuuuuccacccacgcggugaucuccaugcgggaugggaaacugugcuugauguuccgggugggggacuugaggaauuc
ucacauuguggaggcauccaucagagccaaguugaucaaguccaaacagacuucagagguuggaguuuauuccccucaacca
gacugauaucaacgugggguacuacacaggggacgaccggcucuuucuggugucaccauugauuauuaaccaugaaauuaa
ccaacagagucccuucugggagaucuccaaagcgcagcugccuaaagaggaacuggagauuguggucauccuggagggaau
gguggaagccacagggcaguucugaaaucgaaaucaagcagaggucuauaagaacacccuggagacccccaugcugcugga
ucuuggguccaugaacugcuuuuuuugcuacaaucaaaaaugcuagucgcugaucugauaggagaggaaacgagacuca
gagccugaaggauaacacgcugagggcugauuucauacacucuucccggcuggaucaucccagcccccacagcguccaggc
unaguuucuuccuuuguuuuaacaaucuauacuuccuccagccugggcgagcuaguauacccagaguuugguuuuguuuc
uuuucagagcuguaagcccaguuccauuugaccucaucugggaggagaguuaagcaauaagaccugaaauuucuaaacucug
ggguagaaaaccucugcagagacagcgucucugggaagucucuacagagacagaguagggaagucucacgaaggucagagu
cuuacuuccauaccuggagaaauccgcccguccguucagugccgguuucaacuccucugccaaagacuucuuuccaagaca
cugguaucagcuaucccagcaguaacuuuggcaguauauaaaucaauggcacugccccauaaaaccccguugaguaaaaccu
auggucuucaacagcugaggagccuguagcccagcuccugugugaggcuaaggcuguggagaccaugccugcucaccucc
ucguugaaaagcaaaacacuguaagaaaccuaacaugacuuuuuccaacauuucucaggcuggggagaagacuugguccac
aaauuagcuugaggucuugaucuggaucccuagcauccauggaagaaggugggcaugaucacccacacuccucaucccauag
cucugaaugagguaggcagauuccuggggcucaccagcucauccuaacagccaggucccaaugagggacugucuacaaaag
aacaagagguggauccugagaagcgacacccaagcuugaccucuagccccuguacacaccuguuaagcaccugggcaucgg
gacacacacucgcaanuugcaaacaaggcaaauncucacacnucagaaggcacngagagaancccauaagcncaaaaagnun
ggagccaagauugaccauuaugacuuuuugaaaagacuaaaccacuagauagaauguuucauuucuaaaacaccuuac
cugaaaaguauuacugcucuucuuucugcaacuggaccaugcagagauccacaaagagaugcccagagauuauuagugaug
gucaunugauauncacaauguggacucuaagccaaggccccancaacucagauccagaggcugacagugugcunancuuag
agauaccacagugacugccuaaucaccacguccuuaagucaggggaguuuaauuauuuccuaugaacaccgaauggggaca
gcggauuaccaaugaagcaauccaaccugacaauccuaaccacccagaagaggaucgcugggggaaagcaugaauuauuuac
gugucaacaugugcacacuccggccacgcagcucaacagccaggagugcuucnccacuuagcccugcccuggcauccauun
augaucucgucuanuguguuuunacccagcnagcuuuuucucaaaaauaauaucucccagccauaaaccuacucaucug
uguccucuuuauuucaacccacaauuacaucauucacuggcuugcucaguuucuucaacucugaaaugagaaugauaaug
augaugccucnucccccaagccaccauccucccccgugaccuuccuagguacagacucaaaccagggaagauuauuuccuuc
ucauaggccacagaguganaugcaauaaagaacaaagccunguagggaagcagagagaaagaccaguccucacaagagacu
ccauuguuuccaggaacuuugaagcuuggacaaaaugucagaugauccccuuugaaggugcuccaaagagucaaugugaaa
aauauugacugaugugugcccguccacaagccaaggugccucugcccuggucaccuaccaugaauuauaaacugaugauau
uuaaaauaauaaggaacacuggagccggccagaaaggauucugcaaucccauaaauagcaacauucaucacuacaaugccug
ccaacggugaccaugaauguagauuacccccaacucuucuaaggccacuaaggacagggcaaacuaccucugagaauagag
gcucacuguucugcaucccacuucuaaauguuccaugaauuuuuugagacaucucccauaucccuguuagaaagauucaac
cnugugcuauuaaccaaaucaunuugaanuccauaaaccucuacucuaaagnauacacuuuuucuacaanacagacaacaa
auaugacuuuuuccuaugaaagaguaauaaagauacuauaucagucugcuuugacucaaaaaaaaaaaaaaaaaaaaaaaaa
aaaaaaaaaaaa
173 AF093853 Sequence below.
gaguunugguaggcccagguaccuccuccanaanugaccacauanuuggucacanaucaagccnccacaganacaaaaauau
ugaaauuaucccaugcauccugucugaucaccacagacuaaggcugaucuucaauaacaacauaaaaauagaaaaccagguu
cacugcugcggcugcgccnccnuguucucagcgncaccacugccgccaugcccggagggungcuucncgaggacgangccc
ccaacuuugaggccaauaccaccaucggccgcauccgcnuccacgauuuaccuggaaganucaugggacauncucuuuuccc
acccacgggacuuuaccccaaugugcaccacagaacuuggcagagcugcaaaacugacgccaaaguucgccaagaggaaug
uuaaguugauugcucuuucaauagacaguguugaggaucaucuugccuggagcaaggacaucaaugcuuacaauggugaa
acacccacgaaaaaanugccauuncccaucanugaugaunagggcagggaccungccauccuunugggcauanuggaucca
gucgaanaagacgauaacaacaugccugugacgacccguguaguguucauuuuuggcccugacaagaaacugaagcuguc
uauccucuacccugccaccacgagcaggaacuuugaugagauucucagagugguugacucucuccagcugacaggcacaaa
gccgguugccaccccaguuaacuggaagaagggagaaagcgugaugguaguccccacccucuccgaagaggaagccaaaca
auguuucccuaaaggagucuucaccaaagagcucccgucuggcaaaaaauaccuccguuauacaccccaaccuuaagucuuu
gcggaaauuggggcugcaucugcacguccagcacuggggccugaggacgucagccggcagccguggguccuugcagcagg
nccguagaaagancguggcangaucacagccgguccuguagaucgcucgcuauacuacugggucaunaaauggaaauggca
ccananccuucucggaauucuuuacucugugccuucgccaacauucuaccccucugccugucacaaugcccuacuaacugg
cucucuuugaaacgaauuauguauugaagauuccuuaggucucugcagggucuuugaucagcaagcaagguagugucagu
gugggcucugugcuagaaugaugaaacaccuunuguagcuunccgaacggaaucuucugunacccanuunggagagcacu
gacauggggagangcuuncaauucuguauuuuuaguaaananaguggggacaaccgggaanauucuuncagggaaucuau
uguaaguuucuaucgaaguaggcucaanaagccuuucgccucccaaangugcgcauguaccuccuaanguuuccacaucug
cucucuggugaugucugccngugaacgcaccunanaanagacaggcgaugacagugununaccacucagnguccuaguag
ugaguggccauuucuaaauucuacuuuuugagauucaacaaauaaaauccugaucagaaaaaaaaaaaaauagaaagccaa
cauucauguggaaacuaaacaacacuacucaaugauuccuuggucagagaugaaauaaagaaagaaauuaaaaacuuuuua
gaguunaaugaaaaugaagccacaacauacccaaacuuaugggacacaaugaaggcauuucuaagaggaaaacucauaaccc
agagugcauccaaaggaaaaaaaaaaaaaccuagagagaguguacacuagcagccugacugcacacauagaagcucagcaaa
aaaaggaaucaaauucacccaaaaggaauagacaacaagaaauaaucaaacuuaaugcugaaaucaaccaaauggaaacaaaa
agaacuauucaaagagugggccaaaccaggagcuaguucuuugagaaaaucaacaaganagauaaacccuaagccagacuca
cuagagggcacagggacagcauccuaauaaacaaaaucagaacagaaaagggagacauaacaacagauccugaagaaaucca
aaacaccaccagauccucuacaaaaggcuauacucaacaaaacuggaaaaccuggaugaaaggaaaagcuucuagacaga
174 Z19521 Sequence below.
augagcaccgcauaucugaugcgucgcugggucaucgcccugcuccuugcugcugccggaguagcaguagaagacucagg
cagcaggaacgaguuccaguguagagacggaaaaugcaucgcuagcaagugggugugcgauuucagccccgagugcccgga
uggcuccgaugauuuccccaaagacaugcaugucugucaccugucaguccaaucaanucagcuguggaggccgugucagccg
augcauuccuaacuccuggaaaugugauggacagguagacugugaaaaugacucancgaacaaggcuguccccccaagac
gugcucccaggaugacuuccgaugccaggauggcaagugcaucuccccgcaguuugugugugauggagaccgagauugcc
uagauggcucugaugaggcccacugcccagccaccacuuguggccccgcccacuuccgcuuucaaaucauccanaugcauccc
caaucuuugggccugcgacggggaugucgacuguguugacggcucccauaaguauccacagaacugccaggccgaagacac
ggccuccaaaggcguaagcagccccugcuccucccaggagauccacugugguagcagugaguguauccaucgcagcuggg
agugugcagauaucuccuucauucacgguagccgccaaugugaccgugaacaugacugcaaggacaungcgacgagcucg
gcugcgucaaugugacacagugugauggccccaacaagaucaagugucacaguggggagugcaucagcuuggacaaggug
ggaggcuguucccacaucugcaauugaccucaagauuuugcucugagugccugugucccauggcuuccgguugguggaccu
ccacaggugugaagauaungacgagugucaggagccagacaccugcagccagcacugugugaaccuggaaggcagcuacaa
gugagagugccaggccggcuuccacaaggacccacacaccagggucagcaaggcuguugcuccanaggcuaucugucuu
caccaaccgccacgagguccggaauuaugacccuguuaccgcagcgaguacaccagucugcuccccaaccugaagaauguggug
gcucucgacacggaagugaccaacaauagaaucuacugguccgaccugucccaaaaaaagaucuacagcggccugauggacc
aggccccuaacuuguccuacgacaccaucaucagugaggaccugcaagccccagacgggcuggcgguagacaggauccacc
gcaacaucuacuggacagauucagucccaggcagcguaucuguggcugacaccaaguugcguaaagauugaggacacuuuuucc
aagaggcaggguccagacccagagccaucguaguggacccuguacauggcuucauguacuggacagauuggggaacacccg
ccaagaucaagaaagggggauugaaugguguggacauccacucacuggugaccgaaaacauccaguggccaaauggcauca
cacuagaucuauccaguggccgucucuauuggguugauuccaaacuccacucuaucuccagcaucgaugucaaugguuggca
aucggaaaaccauuuuuaggaugagaaccaucuggcccaccccuucuccuugaccaucuaugaggacaaaauguauugga
cagaugucauaaacgaagccauuuucagugccaaucgacucacggguncagaugugaauaugguggcugaaaaccucuugu
ccccuugaggacanaguccuuuuuccacaaggucacacagccuauuaggggugaacuuugugugagacaacagcccuccucccca
auggugguugccaguaccugugccugcccucccacagaucaguccccacucgcccaaauucaccugcgccugcccugaug
gcaugcugcuggccaaggacaugcggagcugccucacagaagucgacacuguacugaccacccaggggacauccgccgucc
ggccuguggucaccgcaacagcuaccaggccaccgaagcacagugaggaucucucagcucccaguacuccuaggcagccug
uguuacaccccagggcucagcacaguuugcgucauuugacaguuuucccaccaauuuccagguuugacauggcuggcangggaaug
aggagcagccacaugguaugaggunccaguccaucuucaucccuauuugcacagguugcccuccuuguccnuggggccguc
cugcnguggaggaacaggcggcugaagaacaucacaancaacagcauaaacuuagacaacccagucuaccagaagaccacag
aggacgagcuccacauungccgaagccauugauggcuanaccuaccccucaagacagauuugucagccuggaggacgaugugg
caugagcagccaugagagccgucucuuuccgggauccauugccaagcuuaagcagaaaagacacucucuccagaccucccca
accagcacugguccugccaccucccugggucuguguugcncaaagcaagauagagcaaagcugggcuggggggccaagcuc
agcuuccugucuucccagguucuguuuuauauauunauugucuuuggacagaaaaggcuacuggcugugcuugaaanacg
a
175 U04354 Sequence below.
accggucaucgggcucuuccuugggcucagggcacggaucaaguccucggcucgcucggccagcaccgcggcaccauggcg
caggagcuacaacaccccguguucgcacgcgcaggccagcaagcuaugcugcaaguguggagggucgaaaagcuauaacu
gguaccggugccccagggugccuauggugacuuuuacgucggagagcccuaccuggugcugcacaccaccaaguccagcag
gggcuucuccuaccgccugcauuucuggcugggaaaggaguguucccaggaugagagcacagcggcugccaucuuuacgg
uccagauggacgacuauuuggguggcaagccaguccagagcagagagcuucaaggcuaugagucgacugauuuuuugggc
gaaaagacuucugcacgugaagggucggagaguggucagagccacugaaguuccccucagcugggagagcuucaacaaggg
cgacugcuucaucauugaccuuggcaccgaaauuuaccaguggugugguuccuccugcaacaaauaugagcgucuuuaaagc
aaaccagguauccauuaucauccgggacaaugagagguaaggaagaucucaacucauugugguauaaaaaggaagugaacc
aucagagcucaugaagguauuagggagaaagccugagcuuccagauggggacaaugaugacgaugucguagcagacauaag
uaacaggaagauggcgaagcucuacaugguuucagaugcaaguggguccaugaaaguaacacugguggcugaagaaaaccc
auucuccauggguauguugcuuucugaagaaugcuucauuuuggaccauagugcugcaaaacaaauuuuuguauagaaag
guaaaaugcuaacccacaggagaggaagacugccaugaagacagcugaggaguuuuuacagaaaaugaaguauucuacua
auacucaaauucagguucuuccggaaguucggunaacaccaauuuaucaaacaguucuuuaaggacuggaaggauaaagacc
agagugauggcuuugggaagguguacaucacggaaaaagugacucagauaaagcagauuccguuugauGccucaaaacua
cacaguucuccgcagauggcagcccagcacaacaugguggacgauggcucuggcgggguggagaucuggcguguagagaa
cagugguagaguccagauugacccaagcuccuauggcgaguucuauggcggugacugcuacauuauccucuacacuuaucc
caaaggacagaucaucuacacauagcaaggagcaaaugcuaccagagaugaacugaccauguccgcguuucugacugucca
guuggaccggucccuuggagggcaggcugugcagguccgugucucucaaggcaaagagccugcucaccugcugaguuagu
ucaaagacaaaccacucauuauuuauaagaaugggacauccaagaaagaagggcaggcaccggcucccccuacacgccuuuu
ucaaguccguuaggaaccuggcaucuaucaccagaauuguggagguagacguugaugcaaauucauuaaauucuaaugacac
uuuuguccuaaaacugccacgaaacaauggcuucaucuggauaggaaaaggugcuagccaggaggaggagaaaggagcaga
guauguggcugauguccucaagugcaaagcuucaagaauucaagaaggcaaggaaccagaggaauucuggaacucucuugg
agggaggggagacuaccagacuucaccauugcuagaaacucgggcugaagaccauccaccucggcuuuaugguugcuccaa
caaaacuggaagauucauuauugaagaaguuccaggaguguucacccaggaugaccuggcagaagaugaugucaugcuacu
aaauguaccuggagacagacccuucuggaagagacaagaguuacaccgauugucaucaucaagcaagggcacgauuccccccac
auucacaggcuaguuucugggcugggacuccagcaggugguaaaaccagcaacuauccuggcuacauuggggcagcugcc
acuuuguuguuggggaauuguuuacuuuuuguuauuggcuuuugaagauaaacuccugccaaauggauauauaucuaua
ucuauaucuauaucuauaucuauaucuauaucuauaucuauaucuauaucuaucuauaucuaaucuauaucuaucuaucua
ucuaucuaucuaucuaucuaucuaucuaucuaucuauaugcuccucuuuuccuucucuuucaaagggaauugcuGuaugu
uacuauacugaaauaaccuaaagcaaccauuuguuuucgagcaauuuugcaaucuggggaccucugaggaaguaauuuugu
cauucagccacugcuagccaaacuugucuuuucccauagagaggaaggagagccacagugcuucuaagcauuuccccgucu
gcuacucuauuugcagugugcuuuacuuuauguauggcuuuaacaauGccuugcuauuucccaucucaagucaaugccac
uuggaugccauucacucccaaguguccuuacauaggaugaacuucuuuagcuuuunuagaaaacuaaaaucaugucuuuua
ugauaaaacacauuuuauuucuauaaguuuaacuuuauauauuugauagcacaugcucaauagcauaaagaauaugcauug
aaugauguuuuucauaauuaaaauauauccuuuugg
176 M35244 Sequence below.
caagguugagagcaagaaggugcaagauguaggccagcagaauuaucagacccaguaucggcuucugccacuggaagaauu
uccaacauaaaacagaugaucaguuugggacaaucgauucugcgaccagagguagugucaucugguuacuuuuaaaauuca
gauugucugguguuuuccaaucacucgcgacuguaauuunaguuggauucuuuagauaauacaaucgcugucgcucuagu
uuauaaagcuauccaagaucugcccagucccagauguccugauuccucagggcggcuauggucugcgcccuucuccugca
gcuggaugccagaccauccuggacucggaucccuuuggguucacacucgcuuagguauuucuacaccgcugugucccggcc
uggccuuggggagcccugguucaunaucgucggcuauguggacgacaugcagguccugcgcuucagcagcaaggaggaga
cuccgaggauggcacccuggcuggaccaagagcnaccaaaugacucagancagcagacucauauagucacaauucaagaac
agcugucuganaggaaucugaugacccugguucaunuuuncancaagagcauggacgacucucacacacuacaguggcugc
aggacugcgauguggagccagaucggcaccugugucucugguacaaccagcucgccuaugauagcgaggaucuccccaccc
ugaguaaaacccanguuccuguacagugguuanacagcacuuuunccucagaucucucagcaccuggagggccacugcncag
augugcugcagaanuaccuggananagggaaggagaggcugcugcguucagaccccccaaaggcacaugugacccgucacc
ccagaccugaaggugaugucacccugaggugcugggcccuggguuucuacccugcugacaucacccugaccuggcagnagg
auggggaggagcugacccaagauguggaguuuuuggagnccaggccugcaggggangganccuuccagangugguucagcu
auggugcugccucuuggaaaggugcagacuuacacgugccauguggaccaugaggggcugccuugagccccucacccugag
augggagccugcaugguaccaanagccuuggauuuggauuguugccacgguuuuuuccauuuugcucauungucucugu
guggcucgcagacccaugaanagnaugcaggugguuagaggaaggcgugacacccaagangcaggcagagacaguccccaa
aacucuagcaacacuauugugcnuugaugaagagaugggcnuuugcuunugcaaaauuaaguccuguaaaacuuaucuag
gccacuccccaggancuucaggaucaucugggagaugccccnuugaguggcngggcngugaggacagcaggccaguucuu
gccacccuggacaganacacaucucaccunucuggcucgaggaucugancaccugucucuugccuacucggcuucuaguca
agcauunugucaccuugucaacagucccagggacacaaaccuucccuccucucacccacagcacucugcauccuacccccaau
gcnucagggacauuunaucaggucanaunguancaauggcuuugaugcagaanagaacuguggacuaauagagauaggg
uuuaauaaaaaaaauaucuuuuu
177 AW121930 uuuuuunuuuuuuunuuuucaacuuuaagacuagauuugaguaucagucuggguucucugag
ggggaccucugucaucacgccuauaaucaucccgagaguagucaucccuggagcuccacg
accgaucaucccgucugucauagcggucuucauagcgguccccaccuccucuguagucau
caucucucccanacccacuuccanaugcccuucugccacugccuauccuggacucauagc
cucuucauagucucugcugccucggucaucauagcgaucccggcccccauagcggucca
ugucucugcgugggccgucccgauauccgucccuauacccaucccgauaccggucugaan
cguaacgaucucgauacuugucuccaaagcuaucaucgccucuucuagguaggaaucau
cacaacugucuguggugggacgggcccuccagucugugucuguuuug
178 A1852632 uuuuuuuuuunuuuuuuuggcccccaggcucugucucnaggaugggaauagaucaagccaa
acagugaaaaauaaggcaaaucguggcuucgggguuugagacuggcaccaauggcaaauc
agcagaggagaugcanauggguuuaacaancacaguungugguuguancaugagcaggcagg
aaacccuugaccaacacccanaguccacgucuucgcauaugcagggcacaacuuccnaca
gcagucucugggcuuggaggcuugnuacucuuccuaccuuucccacccccuaanagacac
caagaugucugcccacgangggaunacaucangcucuucuggcuggg
179 U70475 Sequence below.
uucuagcacagccacggcuacacagacanacccucucucaacuaaaacanagcanaccccccganuauuguuuuuauuuacg
gaugucuguunauugagacgggguucauggcagacaugagugucucagugcauuugcuauccucucuucuaaaggggcgg
gggggguuggugcgcuggagagguggcucagcaguunagagcacugacuucucuuccagaguuuccugaguucanuucccag
caaccacauggugacuuauaaccaucuauagucagaucugaugccunucuucuugccuguaggcagaccacuanauacauaa
ugcagucaucagugagccanacuaanucgaauggguagcuagaucuugungcuunuagcganuanauauungugaaugg
aauugacagucuucucuauucucauucaguuuguuuguguucuuccccaucagucauaacauguagugaacuaacccguc
nggaccaucunaaccauggcuucuccuuccuuuucuguunuanacauaggacauggauungauugacauccuuuggaggc
augacauagaucuuggaguaagucgagauuuugnuugacuuungucagcgacagaaggacuaugagcuggaaaaacanaaa
aacucgaaaaggaaagacaagagcaacuccagaaggaacaggagaaggccuuuuucgcucaguuucaacugcaugaagaaac
aggagauuccucccaauncagccggcccagcauauccagncagacaccaguuauccgccagcnacucccagguacacucg
ucguggugggagcuaaggaaaacucuagugagaaagcagacucucuggaguugaguucuuggucugccauuuacuguguc
uuuugugaagaggagaaguucucaaacuucgcuucuugauaaucaagacacagaucacagggaagacuuuuguaaguucag
aaacauccucugugguuugaugaaacagcggcagaaauacuguugggaguaaaagaaguaggcauugcucauugugguuuaggc
agggcccugauuguauggguaacugacuuaacuguguuaaguaugauucccauuuuauauucccaugucuaaacaacuaaa
gcauuugcccagaacacucagaaagaaaugaagggagguuauugccuagcacagagcccugguucagucccccaucuguu
cguuaaaggggagggacuaauaauuuugaacacaaucugguuugaaucuuuaugcaaaucgauuucugaaaugagaccauagguuu
uauuuuaugaacaagucuuauugcucguugugacccugugcuuagaacauuucauaaaugaugcucucugugccuuuccc
ccuuuccuccaguuuugcccacauuucccaaacaagaugccuuguacuuugaagacuguaugcagcuuunuucauuagacauuccc
auuuuagaugaccaugagguauaaaaauuguuuguuuuaacagcaaaacuucccuuaucugauauuaguuccuuucaugugu
cuccaauuaagagaagaaaagaaaauuuuagaaggaaaaaauugaucaaagaaauugucaaguaaacuguaugagagcuaua
uaaugcuauaaaauaagaccuguaugguucuggugagauggcucaguagguaauuaguacccgacuuucucuuccgaaggucc
agaguucaaaucccagcaaccacaagguagcucacaacauccauaacaagaucugacuucccucuucuggagugucugaagac
agcuacauguacuuacauauaauaaauaaauaaaucuuuaaaaaaaaaaaauaaggccuguaaacuacaaguccauuuuac
uguauagcuguuaaacaggaaucagaauaauuuucccuuugaaacuggauauagauauauaaaauauauugacuaguaaagaa
caacuauuaaucagcauuuggauuaaaaaaucuuaaucuguuauuugaagcauucugcuagauauuauaugucagauuua
aguccuaaugaauguuuuuuuauccauuuugaagucuuugccuuuaaauacauggagugaaauaaccuaggaguguauuuauau
ggagucacugggaggaggaaauguuucauuuuauaaaagcagccugagagcuguaggcccugcugcugucuguucuucau
accuuggcucucacucacaugaaucaaugucacgucaauucuuggcuuucuucacuugcauuucaguucacuuacccuuggaua
uccccagccacgcugaaaguuucaguuucuucacugccccucaucaggcccagucccucaauagcucucuggaggcagccaugac
ugauuuaagcagcauagagcaggacauggagcaaguuuggcaggagcuauuuuccauucccgaauuacagguaagagagcu
cuaggauuugugcuguuuucuugcgggcccuuuuaauuagucauccuaguuauauauuauuacauuucuaccuccucaaag
gaagaaauugaugguguauuuaaauuacucaugagagcuucccagacucacuuaacacacauaguuuuuagguaaucagac
ugaauauuucuggauaaauucauucaaagacugaaagcuaauuuagaguuucugacaaagauaaaauacuuaucuauugaaa
aaugggaguugaaggaauunugaaaagaacaccuuugauuuggggguagggaauugaucuaaaaugcacuuagccucug
cucauacaaugugaccuucuuuccuaguaucuuaauaccgaaaacaagcagcuggcugauacuaccgcuguucccagccca
gaagccacacugacagaaauggacagcauuaccauuuuuacucaucgaucuccucgcuggaaaaagaagugggcaacugu
gguccacauuuccuucaugguuuugauugauucuauucagcagcauccucuccacugaugaugccagccagcuuuaccuccuua
gacucaaaucccaccuuaaacacaaauuuuggcgauugaauuuuauucuugcuuuucauagcagagcccagugacgguuggcagc
augccuuccuccgcugccaucagucagucacucuuucugaacuccuggacgggacuuuauuugaaggcugugaccugucacugugu
uuuucaacccgaagcacgcugaaggcacaauggaauucaaugacuaugacucugcauuuaacugaacacaaguccca
gccgagcguccccagaacacuuccguauagucuuuccauuuacggagacccaccgccuggucagugacucggaaauagagg
agcuagauagugccccuggaagugucaaacagaacggcccuaaagcacagccagcacauucuuuccuuuggagacacaguacagcc
ucugucaccagcucaagggcacagugcuccuaugcgugaaucccaauuuugaaaauacaacaaaaaaagaaguucccgugagu
ccuggucaucaaaaagccccauucacaaaagacaaacauucaagccgcuuuagagggcuucauucucacacgagaugagcuuagau
Caaaagcucuccauauuccauucccugucgaaaaaaucauuaaccucccuguuuugaugacuucaaugaaaugauguccaagga
gcaauucaaugaagcucagcucgcauugauccgagauauucgcaggagagguaagaauaaagucgccgcccagaacuguag
gaaaaggaagcuggagaacauuugucgagcuggagcaagacuugggccacuauaaaagacgagagagaaaaacuacuucagaga
aaagggagaaaacgacagaaaccuccaucuacugaaaaggcggcucagcaccuuguaucuugaagucuucagcauguuuuacg
ugaugaggauggaaagccuuacucucccagugaauacucucugcagcaaaccagagauggcaauguguuccuuguucccaa
aagcaagaagccagauacaaagaaaaacuagguaucgggaggauuugagccuuuucuuuagcuaguguuuguuuuguacugcu
aaaacuuuccuacuguaauguaaaaugcagaaacacuuuauuaaguaacuauacaaaauuauagccaaagcuaguauagcaau
aauaugaaacuuuacaaagcauuaaagucucaauguugaaucaguuucauuuuaacucucaaguuaauuucuuaggcacca
uuugggauuaguuucuguuuauguguaaauacuacagaacuuauuuauacuauucucacuuguuacauuucauagacuuaua
ugacaucuggcuaaaagcaaacuauugaaaacuaaccagaccacuauacuuuuuuuauauacuguaugaacaggaaaugacau
uuuuauanuaaauuguuungcucauaaaaauuaaaaggagcuagcacuaauaaaagaauaucaugacuuaaacuacuuugg
acunuuuugaauuuuauucacacuauuuuccauacaacnaucacuucauuuuaccacauuuggunuauunuacauuuucaaaaugg
guuugaaaauacagaggcaunuuauagccauguguggcaguccaugauuuunuauucccgacauncaggaggcagaagca
ggcagaucccugggcuccaggacggccaaggcuacaugagagccugucucaagaaagacaaacccuuucuauacuaaacgu
uagcuaggauugucaaggagangguanauauccacaaugguaugccugcuguacaguacuguuugcacagagaacanauccu
guaaccuccuguguucuuagaaguggcauucuaagaagggcuaggaaga
180 U09659 ggccagcaggacucuccungcagcagcggcccgaguucagaguccguuagcugcguuuggug
gcgccgaaggcgaaagucaucacugcacanccunuuuaggaaguuucuuccacucuuuugac
agaguauugguugaaaggagugccgccgaaacuguaaccaaagguggcauuaugcuucca
gaaaagucucaaggaaaagugungcaagcaacggucguggcuguggggucaggagggaaa
ggaaacagugcagagauuaaaccugucagugucaaaguugaagauaaaguucuucuccca
gaauauggaggcaccaaaguaguucuagaugacaaggauuauuucuuauuuagagauagu
gacauucuuggaaaguaugucgacugaaaucacuguugaaauggugucacgugaagcugc
cauuccacugaugucugaacuauuucaucauguaaauaauuu
181 AW124785 uuuuuuuuuuuuuuucaggucucauuuucguuauuugaaauucggugcucgguaa
g
uuuuuucucuuccccucaaauuuuauuucaguaaaaggagacuugggcgagguggauacc
ccacagccggauucuucccccccugccccccaggguggcuaaugcuaucuggggagucg
ucauagggaagagaacuaugguuugggcuccugccugaggccuccaaucucagcccagugg
acauaucacaggcagcunaaaaaaaaaacccuaaaaaaaacaccccaaaacacacauuua
aauagguanucaagacagcuunaaaaaaugcacccacucacaccccccucccuuuncuuu
uuggaaaaaaaaanaggaaaaaaaaaaaaaccaaaccgaauucucguuuccucua
182 AF071315 Sequence below.
anuuggcuccgaggccaagaanucggauccaaggcugcgcggggaaaauggcggcggcagcugcggcguggcgaugg
gagcguuaggcagcagcggcauggauuuuggaugcagcaguccccagcgugauggccuccggagugacugggagugunuccg
ucgcucuucauccccuugucauuccuuaacaucucagaccauuuggauccgcaugcgcucccagaaggcacggccuaugcagg
ugauuggggcucugancgggaagcaggaggggcgaaauaucgaagugaugaacuccuuugagcugcugucccacaccgug
gaagagaagauunucauugacaaagaauauuauuacaccaaggaggagcaguuuaacagguuuucaaggagcuggaguuu
cuggguugguauaccacagggggcccaccugaccccucacacauuccacguccauaagcagguugucugagauaauugagagu
ccgcucuuncugaagungaacccuaugaccaagcacacagaucunccugucagcguuuuugagucugucaucgauauaauc
aauggagaggccacaaugcuguuugcugagcucacuuncacucuggccacugaggaagcugaacggaucgguguagaccac
guggcccggaugacagcaucaggcaguggggagaacuccacuguggcugaacaccugauagcucagcauagugccaucaag
augcuccacacccaugugaagcucauuuagaauaugucaagcccucugaagcagcngagguuucccuucaaccaugacauc
cugcguuaggccnaugcccuaugucacugucucccaguncucagcacugacaaguucaagacagacuunuaugaucanugc
aaugacguggggcucauggccuaccucggcaccaucaccaaaacuuugcaacacaaugaaccaguuugugaacaaguucaacg
uuccucuacgaccgacaagccauuggccggcgaaugcagggacuuguuuuucugaucaugguucugcnaaggauaguguugu
gucucagacagcuguuccauuuaccugaguaccacauucccuuuagagaaacucaunaanaaaagagcagccccuuaaaa
aaaaaaaaaaaaaaaaaaaaaaaaaaaaa
183 D49733 Sequence below.
aaaacccaaucuuugguuuuaaagccaaaaauauaagcaaaaugcauaaguuugcauuuuguuuuuuguuuuuucccgag
guccuugaucuungcccccaaanuugagggcauaaaguaancccucaguuaccuaaaaacacagccauuccuuugccauuc
cacucuccuggauuggccgcuucugugcgcgggggagaggugacucacuauuncuacugaggaaaggggagccaguggug
gaagucagguugagucacuaaugcacagcagcuucaccccuccccccaacuuccuuggcucucuggggaugccuugauccuc
ucccucacuuugcaccuacuuccccuggucccucaccacuacccuuugcccacccacucaaauucuungcucugcucuuua
cuccagaaggccaaaggcaaggcuuagaguugaguaggcagggaaccaacauuaugaagccccaggccagaaaaggguuguucuu
gcagagugaggguuggcaugcuggcuccucucaccauaccugcccccgccccuuuuuggguacaggauggcuccuuuaagag
Caguggauccacccccuguagaggagggccuauuagagccucugccuggcugucagugacucaguguucgcggugacgcu
gccucagccucaacaccagccaacccagaucccgaggugcgccagcgcccagcccagaucuccacgccugccauugagcgauuc
gcagcacugucacccugccggccauggagaccccgucacagcggcgcgccacccgcaguggggcgcaggccagcucuacccc
acugucgcccacucggaucacccggcugcaggagaaggaggaccuuucauugagcucaauuuaccgccuggccuuuguacaucga
ucgcgugcguucccuggaggaccgaaaacgcggggcugcggccuucgcaucacugacuuggaaggagguaucagccgaggagg
guccggcaucaaggcggccuacgaguuccgagcuggggugugcccgcaagacccuugauucuguggccaaguggcgcgccc
gccuccagcuagauucugagcaaagugcgugaggaguucaaggagcugaaggcucgguuuagugaggcccggccggccggca
ccagggaggcagcagucgccuguaacuggccaucuaguccccucccuccccgaaacuugccucccgcgaugacuggcagua
ccaanuunnnuunnuunnnuunuuuunnuunuuuunnuunnuunnnuunnuunnnuunnuunnnuunuuuunnuunnuunnnuun
nuunnnuunnuunnnannnnnnannnnnnuannnnnnuannngcuaggccagaunagaaagcuuucuguauuaauacacaguacau
gcaucauucauguucuacauaauuaaggauuaaaggaagcuacauuguuuaauaugaaaaaaaauaggggucuugauaauguagug
ccuagcauuuacgaacuucgggguuuuuggguuugaucccagcaucucacaaaccacguguaaucccagcacuuggaagguagaggc
cggaggauccgaaguuuaaggucauucuugacuacuuagcaaauucggggcacccuaggauaccugagacccugucaugaa
uaaaaauuaaauaauaaauaaaccaauaugauucuagguugagcagcagcuugggcaauguaaugccggaaguuuagccagau
agaggguugcagucccaggaggacccuggcugggagcagcacucaguccccugcccaaccacagggggccaccggguuucuu
aggcgggcgggcggggcgcgggccgucauccccuccugcuccuuauuuuagcccauuguagagucugggccgccugucc
cucccccaggacagggggaggaaauunnnuunuuuunnnuunuuuunnnuunnuunnnuunuuuunnuunuuuunnuunuuuunn
uunuuuunnnuuunnnuunnnnnuunnnnnuunnnnnnuunnnnnnuunnnnnnnuunnngaugccaacaauccuaauguaaugau
uucccucuucugacagcugcggggaccgcagagaggucccaucccagaugcacuccugaaaccuuucuuuucuuuuucuagcaaca
ccaaggaaagagauggacuuuguuagcuggcgcaggcccggcucaaggaccucgaggcucuucuucaacuuccaaggaagcugcccu
gagcacugcucucagugagaagcgcacauuggagggcgagcuccaugaccugcgggggcagguagccaagguaggccgcu
guccugugaccccaguuuaccccaccuuuguccgacauaucauucggucccauuugccugcucaccuucacuucuccagucua
ganuunnnnuunuunnnuuuunnnnuuuunnnnuuuunnnnuuuunnnnuuuunnnnnuuuunnnnuuuunnnnuuuunnnnnnuu
nnnuunnnnnuunnnnnuuuunnnnuuuunnucuagauggggacagccaucaccucuccuuuggcauuuccugaacccccuccca
Ccucuccaugaacuuggcuuucucccucucauucuugaggcggcccuuuggagaggcuaagaagcagcuucaggaugagaugc
ugaggcaaguauaugcugagaacaggcuacagacgcugaaggaagagcuuugacuuccagaagaacauuuacagcgagguaa
gcguuucccgcuguacaggucuuucuuacuuuguggacagcugggaggggucaccuaauaaugccaggcuaagcgagggcugcc
cgugccuggccgguggaguuacgacuucuggucucagcuucuaaggaaccauugcgauguucuaaucuaagugucucccc
Uuaaccuuucaagaacuugcgugagaccaagcgccggcaugagacgcagcuuuuggagaucgauaacgggaagcagcgaaag
agaaaagacauacuccgccaaggugcuggccucauccuguccucucccuggugcugcccuggggacgggugggugguggc
agggggccagggaugccuuccucaggcccccagcuccagguuccugcucucauaacugugugcucccugcagcuguuauaau
gccaggcagucugcugagaggaacagcaacucgugggggcugcccaugaggaacuuugcagcagucuuucgaauccgcauugac
agccucucguucccagcucagccagcuccaaaagcaggugacccucaguuuaccccucccaccuuggcucuggucuaagcaga
uacugcagaauucccacugagaagggggugggggagggacuccaggaccacaugcuaugguucugaaucugaugccugucu
agcuuuccaggggcuucuccuuuaacuagcccgauccucagagccucuauuuuuacugugcauugaagauuuuuuucauguuuc
uucugugccugccggagacugaaccagaggccucuuugcuugguagauaggugcuuucucacugaguuacaaacccagccgc
auucccuacuuggagauagagcuucccuuggacuggacauguagcucaguugguacauuugcuugcuuauauauacacgaug
accuggcuucuauccccaggaaccnnnnuunnnnnnuunnnnnnuuuunnnnuuuunnnnuuuunnnnnuuuunnnnnuuuunnn
nnnuunnnuuuunnnnuuuunnnnuuuunnnnuuuunnnnuuuunnnnnuunnnnucuagagagagccuacagauccugagugucc
cucugccugccccugugccccucccucuucaucgacaucagcccuuaggaggcuucauucagacccuuuaucuuccccggccccag
uuagaaagagcgagagauggcggagaugcgggcgaggaugcagcagcagcuggacgaguaccaggagcugcuggacaucaagc
uguucccuggacauggagauccaugccuaucgaaagcuuucuggagggcgaguuaggagauugugaacuaggaggggucuacag
anuugucaggggccucuggccgcaacuaccaugacuaaccccgcaccgugucuccaccuuccccaggcugcgccugucccc
cagcccuaccucgcagcgcagccguggccgcgccuccucccacucaucccagucucaggguggaggcagcgucaccaaaaag
cgcaagcuggagucuuccgagagccggagcagcuucucgcagcaugcucgcacuagcgggcguguggcgguagauugaagu
cgaugaagaggggaaaguucggcggcugcacaacaagguccaacgaggugggccuaugaaccagauugguucuuuuucaguau
cugggaguucuugguucucguggagcaucugucucccuaucugagaauuuggagugugugguaguccugucaucuuuaa
uuuguuguugaagauuucaugauauauuggauuuggugacccuugagccaauauuucuagguuuuaugccagagnuaguggugg
aaaccugucuuucuuuucuuuuucuuuuuuucuuuuuucuuuuuucuuuuucucuuuuucuucucuucuuuuuuuuuuuuccgau
ggggucuuuugcccagguuggcuuugaucucccuaguuaagcuguuccccugccucagccuuuccauaguagcuggaacugcag
gnuucacacuggcgnccauuccuaccuaagcuccugauuugagauaauccaagagucguuuugaacucccuguccuccuuccucc
uuccuccuuccuccacccuacuuuucauaccaguccauggggcaacuagcagaucaaucgucagaauagugacgauccuuuga
ugaccuaucgcuucccaccgaaguucacccuaaaggcugggcagguggugacgguuugaguggaagggcacuuugggacucug
gcuggaguggagaaguuggccucaggacaggagcauuaaaaauaagcacaucucuuaaaccaucuuucccagaucugggc
uucaggaacuugaugccacccauuagccccccuacugacuugguauggaaggcgcagaacaccuggggcugugauagcagccu
ucgcaccgcucucaucaacuccacuggagaagugaguauguugcagccgguagcuugcuggacaaggcucccccgggugac
cauaaugggaacuagcuaccuccaacccaagggaaccugccuuggguuuaggaucgcuuuccugagcccaagucccaccca
guuaagcaagccagaagucuccccaguagaauaugguuuggaagucagccagugauuuguuaauagcagacuccagcuauacag
agcaccgagcucuuucaguuguguuuccuuuuuuugcgcgugcguuugcgcgcgugugcacaugugcauguguuuauccuuagucc
ccagcaucagaggungacaagguuguauaaaggcccgggacaguucuaagugguuacuauggguagacaggcugcacagcc
cucacccccugacucuugggccugggcuauauguccccacaguuaaguggccaugcgcaagcuuugugucucacugaccaugg
uuuggaggacaauugaggaugacgacgaauaugggagaagagcuccuccaucaccaccguaugaguggcagccgccgcugaaucc
cagcccacaaggguagcccugccagccuagggcagcucucccaccuccaugccaaagucuuuucauuaaagaauguuuugg
aaugccacuugcugcccuguuccuuucuucucucuccucccucuaccuugaacaguugaacccaggugucugguaaggaaggg
aauggggacuugcuuggaugccauggauacuccacaguggcaguggggacagggguucuauauuunguuccugauaaagggcug
ggaggacagagguggccccagcccugccucucuuccucacucccauugcaugcacacuucucuccucucuccuuccacccua
uugcaugcuucuccucagauuucccugcaacaauguucucuuuccuuccuguccccucacaaauuaagucucuccaucuuu
gcucuuccucuuuggauuugccccauaagugucuaagauucaggggagauuaaaggccacagcucuuuuauuucgaaggcuuccu
ggcuuuauuucccccaucaugcccuuccucccagccacaggucuuucccaaguccccaucacuugguugucuggguacagacaga
ggucaccuuccugcccaauggccaggaagcuccaagagcccacagccuaggugccgguccuaagaagucagucccaaacucg
cugucccuccuaagccuuaucucccuucccaggguucccacugcagcggcucgggauaccccgcugaguacaaccuacgcu
Cacgcaccgugcugugcgggacguugggcagccugcugacaaggcugccgguuuggagcgggagcccaggugggcggaucc
aucuccucuggcucuucugccuccagugucacagucacucgaagcuuccgcaguguggggggcaguggggguggcagcuu
cggggacaaccuauucacccgcuccuaccuccuuuggcaacuccagucccaugagccaggugagucaucucugcccuacagca
ggacacugcucacugagcagcagguagggcagcccaagggaguggggucccccuccuugcagucccucuugcauccugcc
Ccuccugucugaaccccagacucgaggucagggcaaggcccagagugugaguuuguuggguggacaaccccuuuguuggucag
ggagggagaguuaagggccagccacugcugcucacaccucuuuccuucucuucucucuuagagcucccagaacugcagcauca
uguaaucugggaccugccaggcagagcugagggcagaagccaccugcuccccccucaccacaugccaccuccugucugcuc
cuuaggagagcaggccugaagccaaagaaaaauuuauccccugccuuugguuuuuuuuuucuucuauuuuuuuucuuu
uucuaagagaaguuauuuucuacaguguuuuauacugaaggaaaaacucaagcaaaaaaaaaaaucuuuuaucucaauccu
aaauccuuccccuuuucuuuuccuuuguauucugccuuuaaaaccaaaggggcuucucuaggagcccagggaaaggacugcuuuuu
uauagagucuagauuuuuguccugcugccuuggcuuuacccucaucccaggacccugugacaauggugccugagaggcaggc
auggagguucucuuucaccaaccuccuccaacaacuugggcccacugccacgccaggcugcagagaaauagggcacaaagaggaug
acugagaaggucaagccccuccccggcacuacacgaggccgaggcuccucugccugccuuaccuucuuccugcccuucccua
gccuggggcgaguggauucccagaggcaaaucugccgugcuugcuuuuucuauauuuauuuagacaagagaugggaaug
acggguuaaggagaaguugaugaucaguuugauuccuaccuuuucccauucuucugagccuggugguucucugucucaauugaugg
agggcaaugucaagugggauacagggaagagugggggacgaaggcucccagagauggggagaaccugcuggggcugguga
gaagucuagaggugcggcgauugguggcuacagcaaacacuaaggaacccuucaccccauuucccaucugcaccucugcuc
uccccuccaaaucaauuacacuaguuguuuccaucccagaugcuuuggugucucuuuguuuuggugugauguguguuuaucag
aggcagacacauacacacaggagguggccacacauucacuauuauauucacuacccaggcuauaaagguauguaugagauagacu
ucuagaaaggucagcauauguggggugagcgagggguguccuuccuaucccucauccauccagcaccuuuuaaaaggggcc
agcaauccacaugugcaucagacacaggagcacagagancggaguuguagaguagggcagaguagcagagcuuccuugcug
cccuguaguucacaggcucuuugaucaugugaucgcu
184 X80899 Sequence below.
gcggugcgaagcgggccuccgccaacauguacuacaaguuuagcaguuucacgcagaaguuggcuggagcuugggcuucg
gaagccuacaccccgcagggguuuagccaguuuccacagaagcaccaccuaucauauuugccacaccaaccaaacugaccu
ccaguguaacagcauaugauuauucuguaaggaacaaaguuccagagcuggcaaaaauuuuuuccagaaggcugauaguuuuc
caccugaaacgaggccuuccagaccaaaugcuuuaccggaccaccauggcucugacacugggagggaccaucuacugccuga
ucgcccucuacauggccucgcagcccagaaacaaaugagcuugccuguggaggacugguucacuuuguggcacaaacccuu
ugaauccucacuuuuucauguuuuccacuuggauagucuacuuacauuuuugcaaacaaauugaaaagauaagaauacauugu
uuugauuuguuuauggugugcagauggccugucagaugucagagcugguuugacaguuaaaacuauuguuuaggaaau
gucacugagccaucacugagcugugcuucugcuccugauuucccuggaguucugcaggaaaguugcucuccagcucauuc
guggccagccgugcucagggccucgggacucaggcggugucugagcgguuaagcgaacgcgnauuccuuuuggaguguagg
uuguaauuggaggaaggaaaacaaaagccagcggacaauuggugaagugagaucugaguuuagccacccuaggaauuucguuccg
ccuugcagaaaacauugagaggaaugauagcaaccugccucuauuugugggcaguugguuucaaagggugugugucucg
cccanaccuagggaaauggguguuuuguuccaucgugggaggauucaccugucagugcugcacauuagacagcugugucag
gacuucuccuuuaauaauacuuguagcuuuacauuauaauuaaccggacugcggaauaaacacuuggaaucaaaaaaaaaaaa
aaaaaaaa
185 D83203 Sequence below.
cugagacagaacgaaacguccgcagauaacuacccguucuggcucuuguuaguucuauguguauggauaaugucuuggga
gguuuugaaauaccacaaaccuugcuagcccagggugcagcugccucugccgucagaccucagauuauaagggacagaaca
cagcacggaaguggggggaucagaaccaugggagauccaggacgaaggguccugugcgcaggugcggcaccgaauccuaua
uuugacauugaagcugucgucagcccaacuaguguguuuuaacauggaagcacaaugacucaggcgcuucagaauguaga
auagagaauaagauagagagcaaucuugacguuuccuguuaaaaaccagacaucauguaacauuacaagcuuaaggcccaau
acuucguauacauucuccaucaucucuguaacaaccaaugagaccuugaacaaaacuaucacaacagagcccuggccagugu
cugaucuccaugucaccucugugggugugacacaggcucgucucaccuggagcaaugcaaauggcacugccuccuaccgga
ugcugauugaagaguugaccacacauuccucagucaauauuucaggucugaagccggggaccaauaauacguucgcuuucc
caaaaucaaaugagacacaggcugacuuugcaguuacagagggaggucccggaugccaaugguuaccaaaagaaucccaguga
ccaaccuaucccaaccacacaagaauucucuugccucuguggacccacccucuggccaggaucccucccucacagagaucuu
gcuuacugaccuaaagccugauacucaguacaauugccaccaucuauucucaugcagcaaauggcacugauggacagcccagg
aacaaaguguuuuaaaacaaauuuccacccaauuucugacguccgaacuaugaacaucaguugccucaagcaugacccugaccu
ggaaaagcaauuacgaugggucccguacuucaauugucuacaaaauacacguggcugggggggaccacuccgucaaccaaa
cugucaauaancugaggccaucauccucggacucagcuccagcaccuuguacaacaucacaguucauccuuuccugguuuc
agacggagggcacaccaagcuuccuccaagguguacacuucccccggauucaggucucugacuuccgaaugacaaauggucaaca
Caagggcaauugguuuggcuuggaggagcaaugacuccaaguccuucgagauuuucaucaagcaggacggaggugagaag
cauucgaaaugcuuucgacgggaaaccagaggcuuauauauuugaagauuuaaaggccuggaaccaguuaccauuuugagauaauu
ccacgaggaccagacgggacagaagggcuguccaguacagugaaugggagcacuuugaccccagugccgugacugacauccgg
gugucaacauuagcaccacugaaaugcaguuggaguggcagaaunggacgaugccucuggauacacuuaccauuuaguu
cuagagucuaaaauuuggcuccaucaucaggaccaacaguucucagaaguggaucacaguaguugagccucaccccaggcaccu
ugugucccacauugaaguaaacaccaccaccaccacggcagccauccgauggaagaacgaggacacagccucugcuuccuau
gccuacuccguccuuaucuugaagacuuugagauggcagcaauguaaccagcaacuucacaaaagacccuucuauucuaaucc
cuugaguuuaaucccuggcaucucuuuacacaggugaagauccuuacacaaauugggggaugguacaacaucacugguaccugguu
ggaagcuguucugunggaaccugaaucagugaccuccuuccacugugaaguggucccuaaggagccagcauugguucuca
agugggccugccccuuuggcauguacacaggcuucgagcugggggucaguuagugauuccuguugacaauaugacacgccua
aagaacugcacaucauaugaugacacaaaguggcaauacggaaguucaccuauuugaauuuuucuaccucguacaacauucagc
aucgccaccuugucaugugggaagauggcgcuucccgcccagaacaucugcaccacuggcaucacagacccaccuacuccgg
auggauccccuaauauuacaucguucagucacaauucauuaaagguuuaaguucagcggguuuuaauuccagccacggaccua
ucaaaaccuauuggcugucauccucaccaccggggaagcugcccaaccuucuugcagauguuuugaaguacacguaugaauauu
ucaaaaggggagccucggauacuuaugucacauaccucauaagaauagaagagaagggacagucucagggcuugucugaag
ucuugaacuaugaaauugauguggggaaccaauccacuacccucggcuacuacaacgggaggcuggagccucugggcuccu
accgggauugugguugcuagcuuuaccaauuauuaccuacaaccuucaggaaugacggccucaucaauagggaugagagcuaug
ugucuuucaguccauauucagaggccguguucuugccccaggauccaggugucaucugcggagcaguguuuggauguauc
uuuggugcccuggccaucacagcuugugggaggcuucaucuucuggagaaagaaaaggacagaugccaagaauaaugaagug
uccuuuucucaaauuaaaccuaaaaaauccaaguuaauccgaguuugagaauuuugaggccuacuuuagaaacauucaagcu
gacucuaacuuuguggguuugcagaggaauaugaggaccugaagcugauugggauaaguuuuuaccuaaauacacagcugagau
agccgagaacagagggaagaaccgcuacaacaauguucugcccuaugauauuucucgagucaaacuuucaguccagacccau
ucgacagauuuacuacaucaaugccaacuauaugccuggcuaccauuccaagaaagauuucauugccacacaaggaccuuuc
ccaacacuuugaaagauuucuggcguauaguuuugauagaaaaacguauauaccauuuguuauguugaccaaaugcgguggagg
cagggaaggaccaaaugugaggaguacuggccuuccaagcaggcucaggacuacggggacauaacuguggcgaugacauca
gaaguauuucuuccagaauggaccaucagagauuuuguuugugaaaaauaugcagaauagcgagagccauccucugaugcag
uuccauuuucaccuccuuuccuaaccacggugguuccugacaccacuggaccugcucaucaacuuucaguaccuaguccgggau
uacaugaagcagauaccccccgagucaccaauucuggugcauugcagugcugggguuuuggaaggacgggcacuuuucaucgcc
aucgaucgccugaucuaucagauagagaaugagaacaccuuuggacguguaugguuauugucuaugaccuucggaugcacag
gccucugauggugcagacagagggaccagguauguuuuccucaaucaguguuuuggauauuaucagaacccaaaaagacuu
caaaaguugaucucaucuaucagaacacaacggcaaugacaaucuaugaaaaccucgagccaaguuccuugaaugugacuau
guugcuucauccacagcugaacgauuuuggauguuggguucuagguccuggcuguugcuggucugcuaggauccagggc
cuuguugacaucuaggaagauauuaaauuaucccgcugaaggccgcaguuuuagauuguagccacuagauggagccagagca
cugguaugaaggagcaccagggccguguaaggcaaaagaggacccagaaaaagaaacuuaacuuguucacuuuccuuugagaaacc
gcaagucaacaagccaaggaaguugccuuugcauuuucauuugguagccuuuccaaucccgcuuauuacauaauauguucaug
uucauggcaaaaaaaaaaaaaauaaaauaaaauaaauaaaaaaggaaaacaaaauaaaaaaaaucuuagaacauu
186 Z20410 gcccccucaagggcanccugggcuacacngagcaccagguggucuccucugacuucaac
a
gcgacacccacuccuccaccugacgcuggggcuggcauugcccucaacgaccacuuugu
c
aagcucauuuccugguaugacaacgaauuugcuacagcaacaggguguggaccucaugg
cccacanggccuccaagguaagccccuggaccaccaucccagcaaggcacaagaggaag
g
agagacccu
187 AI839906 uuuuuunuuuuuunuuucauauuaacuuguaguuuuauucagguuuganuuuuaac
aaaugugucagggagagagcccacaggaaaggguaaagcccgugggggcaaggccuucc
cagaugccugaggagggaucguguccccucccccccuccucuucucaccaccccuacag
ggguuuaggaagagacacaggcagggaaagggcngguccccagncuguacaguggngc
uugggggugaaggacuauggagaacaggggaccagaucggggaugaguaggauaaagg
gcacaagaccauuuaccagaauccagcuuucugauuccaaauugaauuaaaaagaaaaaa
aggagagacgaaccuaaaccacaagcaguacccaacucccuuncccccaucago
188 AI843448 uuuuuuunuuuuunuuuuagggaagaggcuuuugccagauaaguuuuuauuuauuuaa
aaaaaaaaaaaaaaccagugcaacuggaaaucagguuugagucgcuggaggugagugaga
gucggaaggcccuccacaccucagugguggcaggaucuggacccguagccuaagccugg
ucugauccagccgagaugcuggaaagcagagcacacgguggugcccaucagggcaaaga
ggacaagagagcccacggcuccuccauaccacuugcuagggucuccuguguaguaacca
uaugcguaaaggacucgcccaauaauccaggccaggcccaggccagaagcuaugcgcgg
gugguaaacaccucccaccguuaggaaaaa
189 AW125336 cggccgcgugaguuuugacugagcuucugcangaaguucanaugcaacuccauacauca
guucauuuucuagcauuaccacuggguuauuaucacgaauggccgauuuaauaagucc
uuuugcauccucggaauuccaggggcugaccacunuuaaccugggcagugcccauacc
augcagcaaagcauugcgagugcugagcagcuacaccugcugaggcgccauugggcccc
cugaauacuaugggcaca
190 AW123802 uuuuuuuuuuuuuuuuugaagggccauuggaguuuauuuacagacaaccuuagguga
ggccuuuuccucuaggaucuacaugcuuuugaaguuacuugguuucaggcuucuuguc
uccagcuncgagcuugagacucucaggaggcuagcgauagacagggaaagccucccagg
ggcuguucaggucaaacuugcggaauucuugugccagcuccacugguucagccacuacc
cgcuuuaccucaucgucguaacgaagcucaacauagccagugaggggaaagucuuuccg
gaaaggangucccucgaagccanaancugucaggauccuucuuaaaucagggugauua
aaaaaaaaaaaaaaaaaaaa
191 AI835771 uuuuuunuuuuuunuuugggaggcagcaaacuuuauugaugguauncaaaaaaauag
ggagggcucccuaggcccccccuguuauuaugggggucugggauggaaauuuugaggg
aaaugcucaauuuugggggcccauuugggaaaaggccccccuugcccaauguccuugcu
ggggugagugguccaaggnuuunacuccuuggaggccaunuuggccaagagguccac
cacccuguugcuguagccguauucauugucaaaccaagaaaugagcuugacaaauuugu
cauugaaaaaaaugccaaccccggaaucaaagg
192 X53584 Sequence below.
gcuccucaucucacucaggccuaugccaaagauguaaaauuugaugcgaaugcucgagccuuaaugcuucaagguguagac
cuuuuagccgaugcuguagcuguuacaauggggccaaagggaagaacagugauuauugaacagaguuggggaagucccaa
aguaacaaaagauggggucacuguugcaaagucaanugauuuaaaggauaaanacaaaaauaucggagcuaagcuuguuca
ggaugugccaauaacacaaaugaagaggcuggggauggcaccaccacugccacuguucuggcacggucuauugccaagga
gucuuuggagaagaucagcaaaggggcuaauccaguggaaauccauagagguuguggauuguuagcugguggaugcuguaauug
cugaacuaaagaaacagucuaaaccugagacaaccccagaagaaauugcucagguagcuacaauuucugcaaacggagacaa
agacauugggaacaucauuucugaugcaaugaagaagguuggaagaaagggugucaucacagugaaggauggaaaaacccu
gaaugaugagcuagaaauuauuuuaaggcaugaaguuunuagaguuauauuauuuccccauauuuuuuaacacaucaaaagg
uugaaauugcuaaugcucaucggaagccauuggucauaaucgccgaagauguugacggagaagcucuaagcacgcugguu
uuuuaacaggcuaaaaguuggucuucagguuguagcagucaaagcuccagguuuuuggguuacaacaggaagaaccagcuuaaa
aauauggcuaucgcuacuggugguacgguauunuggagaagaagguuuuggaaucuuaaaucuuggaaaauguucaagcucauga
uuuagggaaaguuggagaggucaucgucaccaaagaugaugccaugcuuunaaaggaaaagguugacaaagcucacauuga
aaaacgguauucaagaaaucacugagcagcuagacaucacaacuagugaauaugaaaaauuaaaauucugaacgagcgacuugcu
aaacuuucagauagaguagcuguguuggaaaguuggaggaacaaggugaugguugaaguugaauggagaagaaaaacagaguuuac
ugaugcucucaaugcuacaagagcagcuguugaagaaggcauaguucuaggagggggcugcgcucugcuucggugcaucc
cagccuuggauuucauuaaagccugcuaaugaagaccagaaaauagguauagaaauuauuaaaauuagcacuuaaaauuccug
caaugacgauugcuaagaaugcaggugguugaaggaucuuugauaguuugagaaaauuucugcagagguuccucagaaguuugau
uaugacgccaugcuuggagauuaugugaacaugguggaaaaagggaucauagauccaacaaagguagugagaacugccuu
acuggaugcugcugggguggccuccuncuaacuacagccgaagcuguagugacagaaauuccuaaagaagagaaggaccc
uggaaugggugcaaugauuggcauugauaggauguauaggagggcucauauucuaacuccuagaguagugcuuuugcccuu
aucaaugaacugugacaggaagcucaaggcagguuccucaccaauaacuucagagaagucaccuggagaaaaugacugaaga
gaaggcuggcugaccacuguaaucaucaguuacugguuuccuuugacgauauauaaugguuuacugcugucauuguccau
gccuacagauaauuauunuuguauuuuugaauaaagaacauuuguacauuccugauuucugguugcaagagccauauacca
guguccugcuuucaacuuaaaucacagaggcaucaucuacucuacuuugugagucaucaggacuguagcgcugugucaacaaaa
cauagagaguucagaagacagccuuucuguggaagggugggaaugauuguguacaaaguagagaaguauccaauuaugug
acaaccuuuguguaa
193 M32599 acagccacaucuucuuuguacaaugccagccucgucccguagacaaaauggugaaggucgguguaaacggauuuuggccgua
acuacauggucuacauguuccaguauuuacuccacucacggcaaauucaacggcacagucaaggccgagaaugggaagcuug
uucaucaacgggaagcccaucaccaucuuccaggaggagaccccacuaacaucaaauaggguugaggccgguggcuugaguaug
uccgccccuucugccgaugcccccauuuuuugugaugggugugaaccacgagaaauaugacaacucacucaagauugucagc
aauugcauccugcaccaccaacugcuuuagccccccuggccaagguucauccaugacaacuuuggcauuguauaagggcucaug
accacaguccaugccaucacugccacccagaagacaguggauggccccucuggaaagcuguggcgugauggccgaggggcu
gcccagaacaucaucccugcauccacugguugcugccaaggcugugggcaaggucaucccagagcugaacgggaagcucacu
ggcauggccuuccguguuccuacccccaauuuuguccgucguggaucuuuacuuugccgccuggagaaaccugccaaguaugau
gacaucaagaagguggugaagcaggcaucugagggcccacugaagggcaucuugggcuacacugaggaccagguugacucc
ugcgacuucaacagcaacucccacucuuccaccuucgaugccggggcuggcauugcucucaaugacaacuuugucaagcuc
auuuccugguaugacaaugaauacguucuacagcaacagggugguggaccucauggccuacauggccuccaaggaguaagaa
acccuagaccacccaccccagcaagaacacuaagcaagagaggcccuaucccaacuucggcccccaacacugagcaucucccuc
acaauuuccaucccagacccccauaauaacaggaggggccuagggagcccucccuacucucuugaauaccaucaauaaaguu
cgcugcacccac
194 AF035644 agaagcuuccuaaagaacaagcaaguugaauagagaaaauagugaucaauaauaggcauu
uuaguggucuuuuuaauguuuucugcugcggaacauuucaaganuuanugauuuccucc
uccccccauuuuuuucccaccacacucacacacgcacgcucacacunnuuannugccauaa
ugaaccguccagccccuguauagaucucuuaugagaacauacguuuucugauaacucaca
accccaccaaugcgacucucaacaaguucacagaggaacuuaagaaguacggagugacaa
cuuugguucgaguuugugaugcuacanaugauaaagcuccaguugaaaaagaaggaaucc
acguucuagauuggccguuugaugauggagcuccacccccuaaucagauaguagaugauu
ggcuaaaccuguuaaaaaccaaauuucgugaagagccaggcuguuguguugcagugcauu
guguugcaggauugggaagggcuccugugcuaguugcgcuugcauugauugaaugcgga
a
ugaaguaugaagaugcuguucaauuuauaagacaaaaaagaagaggagcauucaauucca
aacagcugcuuuacuuggagaaguaccgaccuaagaugcgguuacgcuucagagauacca
augggcacugcuguguucaguagaaguagaagcaggcuggcuggaucguggcauuagag
g
gaa
195 Y00629 Sequence below.
auucagguuccucacagacccagggggugaggauauugcuuuuugcccacuugcuucagcuacuggucaacgccacaguc
ccgacccagaguaguaagugaggggaggggugaggggagggguugggagcgaaaaagacucugugaggaaaagcgggagg
guggugguggcggaggugcagcaccccaaguuccgccuucccuguccuagucccucccccgccuuuaccugggaccnugagc
cugggggagaucgaugucucaccgcgcaccgcccccaagcccacacucgcugcgguauuucaccaccaccaugucccagcc
cggccucggggagccccgguucaucauugucggcuacguggacgacacgcaguncgugcgcuucgacagcgacgcggaaaa
acaugguugaggaacuucagaguaaaccugaggacccugcucuugcuacuacaaucagaguaacgacggugagugcggcuuugg
aucacagcuaugaucacuccauguccccugagacgggccugggucaucuugacccgcugagacaaaguuncauccaaacgc
cuuacccagaaccucagacaaaaaagcccccgcagaguucugcunaggunuggggunguacuuuugnuucucuuunguuuu
gagauaucuacuaacauugggcaaaguggccacauuguggcgcucaucagcguaucccuuccagaaucucacacgcugcagu
ggauguacggcugcgacguggggcccgaugggcaccugcuccgcggguauugucaagaggccuacaauggccaggauuac
aucucccugaacgaggaccugcguuccuggaccgcgaaugacanagccucacagaucucuaagcacaagucagaggcaguc
gaugaggcccaccaacagauuggcauaccuuucaagguccuugcguuugaguuugcuccauaganaccuacggcuuuggaaaugag
acacugcagcgcucaauugcccuagagagcucuccucacuuuuccucugcauuuuggaugaaauccuuaagguauaaccu
caggggcagaacgcuguncagcgggcacagcgcggaggaggagggagagggacucccaaaacugcuunuccccuguaggga
uucuaauccuuaacaaaagcagaucaggcucgacaauggcccuggacccauggggguuaggguugcucuuucucaggccuccc
uccuugcccuacucagugucucuauagucagacuccagcuuuucucaaucucuuggcccucauccaacucaggaccagaag
cccuucccaugagucugcagagaccuggagccuccuguccauguuguccugcucacauccuaaggcaucccuaagagcaga
uccucccaggugcaggugcucnagcuggugucuagaugaugugcaccauaaucccaccgcaguccuccuguccaccccagg
acggucacaugaacacugcugaguccccagaagaaaacaagaugccucauccuuucaacucucucccucagacccuccaaag
gcacaugugacccaucacccuagaucugaagaugaagucacccugaggugcugggcccugggcuucuacccugcugacauc
acccugaccuggcaguugaauggggaggagcugacccaggacauggagcuuguggagaccaggccugcaggggauggaac
cuuccagaagugggcagcugucuuuggugccucuugggaauugagcaguanuacacaugccauguguaccaugauugggcugc
cugagccccucacccugagaugggguaaggagggugugggugcugaacuggggucagggaaagcuggagccuucugcaga
cccugagnuggucauggcucagagcugggaucauaacccucaccuucauuuccuguaccuguccuucccagagccuccucc
auccacugucuccaucauuuguaaucauagcuguucuguuuuguccuuguuagcugugaucauccuuggagcugugguggcuu
uugugaugaagaagaggagacacauagguaggaaagggcagggucugaguuuucucucaaccuccuuuugcagugugcuc
ugcuccuuaaugggaaacauagccacacccacauugcugcagucuccaacugggucagcngucaguuccgggaacucccna
gggcugguguuucucuggucucucauggcuuuucuucucacagguguaaaaggaugcuaugcucauguucuagguaaguu
gcgagagaggggcaggggacacccuugucccugaggcucucaggauggagcugggauuuguuccagcccauaaucuccuc
uugccacauccucucugucuccucugugugccuuguuaucucuucuacugcaggcagcaagagcuuccagaccucugacug
gccucagaaggcaugaaaaucccugggggggcuggugagauggcucaguggguaagagcacugacugcucuuucugaaggu
ccagaguucaaaucccagcaaccacaugguggcucacaaccaucaacgagaucugacucccucuucuggagugucugaa
gacagcuacaauguacuuacauauaauaaa
196 AW125380 uuuuuuuuuuuguucccuugaaagccagauguuccaaaaaguagccugcuccauuguuc
u
ucuucagucucauagcgacugccagcgucaauccacacucccaccgugcagguagcaugcg
aggacugcuccgaggccacacgcagcccguuguccaagaugcugaccugggucuccggca
cgcucuagaggaccugggcgaagguugcgguaccccacaaggcagguaaccucagcaggg
ccggcgagcggcgggugcgccucgugccg
197 U68564 Sequence below.
ggagcuuaauguuuugaccuguagagguccucacuuuucgucauggcgcugaagguggcgauagcugcuggcggugcug
caaaggcaaugcucaagccaacucuccucugccguccuugggagguucuggcugcccauguagccccccgaaggagcauuu
ccucacaacaaacaauuccuccaucugcuaaguauggugggcggcauacagugacuaugaucccaggggauggcaucggcc
cagagcucauguugcauguuaagucuguauucaggcaugcaugugugccgguggacuuugaagaggugcauguaagcucc
aacgcugaugaggaggacauccgcaaugccaucaugaccauccgccggaaccguauggcccugaagggcaacauugaaaca
aaucauaaccugccaccaucccacaaaucucgaaacaacauccuucgcaccagccuagaccucuaugccaacgucauccacug
uaagagccugccaggaguggugacccggcacaaggacauagacauccucauuguacgggaaaacacagaaggcgaguacag
cagccuggagcaugagagcguagcaggagugguggagagcuugaagauuaucaccaaagccaagucccugcacauugcuga
auaugcuuucaagcuggcccaggagagugggcguaagaaagugacggcugugcacaaggccaacaucaugaaacuggguga
uggacucuuccuccagugcugcagggaaguagcagcccacuacccucagaucaccuuugacagcaugauuguagacaacac
aacaaugcagcugguaucccggccucagcaguunugaugucauggugaugccuaaucucuaugguaacauugucaacaacgu
cugugcagggcuaguuggaggcccaggccuuguggcuggggccaacuuauggccauguguaugcagauucgagacagcua
caaggaacacaggcaaaaguauugccauuaagaacauugcuaacccgacugccacacugcuagcaagcuugcaugaugcuaga
ccaccucaagcuccacuccuaugccacuuccauccgcaaagcugucuuagcauccauggacaaugaaaauaugcauacccca
gauauuggaggccagggcaccacaucccaagccauccaggacaucauucgucauauccgcaucauuauggacgggcugug
gaggcuuagcuaucccuacaguuuugcucagcuugucuguaggacucucuucucacuuuagcacuccagcuagcuugggg
gacaggaccca
198 AW125346 uuuuuuuuuuuuuuuuuguucuuaauagaaaacuuuauuuucacugauaaugucacugua
acauaauuucauagcagaccugugcaaaagaucccacaucaccaaugucuccaagagauu
ucacacacuucugggcaggacacacaacucugcccccacccccguguugacagucaacau
uuuacccccgcuaugaguacagaaaggcgaggcaucauaacgaagccgccugaaggcagc
gugagcugaagucggacgcuuugccaccucugaaugaaugguucaccacagcaacagcacau
gguugccucagugugcucagggugggucuuugaaaaaacgucccacuauguaaauaugcu
gcacuuaucccuucaacauugu
199 X61232 See above (same Accession Number).
200 D20333 gauccuguauauguguguuuugggggagcuaugauaaguuuuauggcaaacgguugguau
uguuaacuuuuuauugucaucaaaaguucauaaaaguccuauuaauccccauauucunnn
uucugcccuuaacucugguauacaccaaaaagaaaucuuuuacuuuccuuguuuuuaucauua
uaaaaauaaaguauuuugcuaguauggaaa
201 AB025218 aguccgcaucccggcguucggcccgucccgcaccauggugacgcucgccgagcugcuaucg
cugcuggccgcgcugcuggccacggccucgggcuacuuugucagcaucgacgcgcacgcc
gaguuaguuuuucuucuuagcgggucaccuccggcaccaagaugggccucaucuucgaguuug
gcggaaggcaucuuccuagacaucgacguuggagaucacaggaccagauaauaaaggaauc
uauaaaggagaccgggaguccagcgggaaguacacauuugcagcccacauggaugggaca
uacanguucugcuuuagcanuaguuauguccacuaugacuccaaagauaguaauguucacc
auugacauuggggaggcucccaaaauacaaaacauggagacagaaacucaucagaacaag
cuagaagaaaugauuaaugagcuggcaguggcaaugacagccguaaagcacgaacaggag
uacauggaaguccgggagagaauacacagagccaucaaugacaacacaaacagcagagug
guccuuugguccuucuucgangcucuuguucuaguugccaugacauugggacauuaucuac
uaccugaagagauuuuuuuugaaguccggaggguuguuuaaaaggccuuuuuccuguugaucc
caaauucaugauuuacu
202 U84411 Sequence below.
acauuggcucuaugcugcggccggcuucagcgacgcuuccucgggcagcucacugcauggucuacuguagcccccgccgccu
gcauccccgccgccgccccgcgacgcccaccgccgccugcccugccgccgccgccugcgccgccucgggaccggcuguauga
uaggccacaaucuucaaugaguagacauauuccucaguucuguguuuguucucguuucacacauuuauggaguuucuuuaag
agcaguggagauuacugccagcacagcacgaccucuuaugcagacaagugaacuguagaaauuucauuacuacuccaccaaga
aacccccauaagaguggauaaccuggacacaggcguguugaauugaaaucugcacagcauuugagaagagcucagaccugg
augggguaaaccucagugccacuuccuuuguauugccucuaguauuacugggauugaagagucacugcuucuuguuuagg
agguucauuucauuuggcccguuuucucccaauuucauacucaagcacugagaauuucaaguggaguauuaucgaauaucaaag
uagacuucagguuguuuuuugguuuuguuuuguuuuuuuuuuguuuugguuuuuuuuuuuuuuuucuguuuugguuu
aaaucauuucuguauucaauuuuuaauucuuucauaacccuauuggguguuuuuuuaaacuaaauuaacauggcucgaa
ugaaccgcccugcuccuguggaagucacauacaagaacaugcgauuucuuauuacacacaauccaaccaaugcgaccuuaaa
caaauuuauagaggaacuuaagaaguauggaguuaccacaauaguaagaguaugugaagcaacuuacgacacuacucuugu
ggagaaagaaggcauucauguucuugacuggccuuuugaugauggugcaccaccauccaaccagauugucgaugacuggc
uaagucuugugaagauuaaguuucgugnagaaccuggaugcuguauugcuuuccauugugucuucauugccuuggcagagcu
ccggugcuuuguugcccuagcauuuaauuuaaaguggaauugaaauaugaaaaugcaguacaauucauaagacaaaagcggcgu
ggagcuuuuaacagcaagcaacuuuuguaucuggagaaguaccguccgaaaaugcggcuccgcuucaaggauuccaauggu
cauagaaacaacuguuguauucaauaaaacuggguuugccugaugccauugccuuggaagugnacuucagaugggaccuga
unuuaucaugcauauuacccaaugugucggcuuacugaauaaguucuacugcagcuccacaggaauacuuaaaaaccagucuuu
accaggccacaaguuugacagaauugcaaccucuauauuugggcuaugaucaacauguuuggacacuuagcaaaagauuuu
ugcuuucagcauuunaaaugugcuuauuauuuguaccaauugaccuuuccuaaaauaagguauugaguuaugucauuaa
auguacuccugugccagaauauuauuagucuauaaauaauuuagaaagauuagguaccaaaauacccagcacaauacuugu
auauuuuuagcaucauacagaaccaaaauugcaggaacugagaacucucagaccauccaugguguauuccuucagucauuu
caaacacugcagggcuccucucguuaucugccugcucacucuguuuacaucucccacacuuaugccagaauacgucagguu
uugcuuaaccauccuuuauuuuuuuuuauuuuuuuuuuuuaacuaagucuugcgcugauuauuuaauaugucuuacucauuu
uguuuuguuuugggaaaccucugucugaaaaaucaacuuuguuacagaagcacauaucuucaacaaugucuccagacaaaa
agccuuanaguuaauuuaauguuugcacucagaagugcaaccuaacagggagggccugaaaaagaaacgagaggaggcuau
uaaauauuuuuauuuaauauguugccuuugucaugugcagaacauguagauuuaugcucuuaauuaguanauauuuuaag
acauagagauacauguguagcuaacccauucuuauucaaaauucuggaauuuuguguuuuccnauaccuaucaggaaguu
uccagcuuguuugaauuauggcuuuccucuucccaaucucuugcaaaaaagacaaagugggaugaaucugcuagugaacug
agcagaaauguuuuauaacgccuuuugagcuauguancuuaauaauuggauacuugaucauuuguuuuauunuguaaucg
aauaaaauguagauguguauuaaaguuaguucaaccauauauuuuacuaucuaugaauguuguaguuauaguucuuguau
gagaaauaguuugucaguguucaccagcuuguaaaaacuuaguaugagagcuucaacauuuaaanaaaugaugaaccgcau
ucgucacugaggacacuuuugccuaaaauuaacuuaauuuguagaaaacaauggauucaguuaauaucauuucaauuuaug
gaaaaaauuuguuaggguugccaaguugcuuuuuuauuuaaaaguuucuucuuuaaaaucuagauaauuguugaaucaguugaau
guugggcaccgaggggaaacaguuuguaauagaugaucuagauuuuucaguucaguuccaucagucacuuguagcucugc
aauuuccagaccaguuuucucauuuuuaaguucauuacaugccuguauauauuuugaaauuaacuugaaccugaguauuu
ggcacaugauggcnuaauaaauunuaacuuuc
203 M62362 Sequence below.
acacuccccaaccuccaccuccccucgcucggccucuuauaugcucccaugcucccuaguguuuggcuggaaguaggugacuu
agaggcuuaaaggaggggcgccuaaccacggaccacgugugugcgggggcgacagcgccgccgggguggggcugagcgcu
gcaagccggguucgccuugcagcgcaggagucagugggcguugcgccacgaucucucuccacuagcacuaugcucccgccc
cacucaccgccuuggaaaguucacaggagaaggcgggcucuuaagacccagcaggcaccauccuacuaucgccuucgauccgag
acccguuuggacaccagggggcgaugccgacccucuauaaaagcgguccccgcgcgggccuggccauucgcgacccgaagc
ugcguggcgcgagccaguuggggcacugggugggcggcggcgacagcggcgccacgcgcaggcuggaggccgccgaggc
ucgccaugccgggagaacucuaacucccccauggagucggccgacuucuacgagguggagccgcaucccccgaugagcagu
caccuccagagccccccgcacgcgcccagcaacgcccgccuuuggcuuuccccggggcgcgggccccgcgccgcccccagcc
ccaccugccgccccggagccgcugggcggaucugcgagcacgagacgucuauagacaucagcgccuacaucgacccggccgc
cuucaacgacgaguccuggccaaccucuuccagcacagccgacagcaggagaaggccaaggcagcggcgggccccgcggg
uggcggcggugacuuugacuacccgggagccccggcgggccccggcggcgcggucauguccgcgggggcgcacgggcccc
cucccggcuacggcugugcggcggccggcuaccuggacggcaggcuggagccccuguacgagcgcgucggggcgcccgcg
cuacggccgcuggugaucaaacaagagccccgcgaggaggacgaggcgaagcagcuggcgcuggccggccucuuccccuac
cagccaccgccgccaccgccaccgccgcacccgcacgcgucucccgcgcaccuggccgccccccacuugcaguuccagaucgc
gcacugcggccagaccaccaugcaccuacagccuggccaccccacaccgccgcccacgcccgugcccagcccgcacgcugcgc
ccgccuugggugcugcgggccugccuggccccgggagcgcgcucaagggcuuggccggugcgcaccccgaccuccgcacgg
gaggcaucggcgguggcagcgguaccggugcgggcaaagccaagaaguucgguggacaagaacagcaacgaguaccauguac
ggcgggaacgcaacaacaucgcggugcgcaagagccgagauaaagccaaacaacgcaacguggagacgcaacagaaggugcu
ggaguugaccagugacaaugaccgccugcgcaagcggguggaacagcugagccgugaacuggacacgcugcggggcaucuu
ccgccagcugccugagagcuccuuggucaaauccauggcaacugcgcgugaggcgcgcagcugcgggaccgccuuugggcc
ggcccccuggcuggagacccagaggaugguuucgggucgcuggaucucuaggcugcccgggccgcgcaagccaggacuag
gagauuccgguguggccugaaagccuggccugcuccgcguguccccucccuuccucugagccggacucggugcgucuaag
augagauagucaauccauggugguuucuccuugagaccgagagacuuuuccgcggagcugagcuggaugcccggcaguac
cuugauauuuuuuuggaggauuccugcuuccucucgggccucagcuggcccccgugagaaaaaugaagggugcaggccc
agggcaggaggaagauacaggaagcugagaucccggcaguugcccugagcuugccccucagucccugucuuuuagagaugagg
gacuuagguguuggggauuugagucuguguccucacccccagcuacagggagguggagggcuccuaaucccuugcuuuuu
gcaccuccaccuacauccccccccccccacucagcuuacaacaggccagguuuccugggugaguucauggagaaugggggca
ccacccccagucagacagaaagcugaguugugaguuagccaugugguaggagacagagaccuagguuucugggcuuugug
gggugggggauaggaggacacggggaccauuagccuuguguguacuguaugucgccagccgcuguugcugaaggaacuug
aagcacaaucgauccaucccagagggacuggaguuaugacaagcuucccaaauauuuugcuuuaucauccgauaucaacac
uuguaucuggucucugugucccagcggugccuugugcaauggcagugugcacgucuaugcuaaaccaccauuuuauuugg
ucuuuuguuuuguuuuugguuuugcucugauucuugccaaacugagacucuucacuaacagcuaugggaaggagcugagu
gaggcucucauucuuuuugguuuaguugauguuuggguuuuucgucugccucccagaggaccaaugaaaugaagugggc
uucccccucuccccuaguuguccaaggguguauguaguagugggucuuagcuuccuccggcuaagacuuaggcuucccca
cccacccaaccccauccccaacaucccuuucucugggucuggaaagaaggccaccuccaaccaguucauacacacaccccug
uggcugggagcagggcuggaccgcuuccuucucuucuuuuuauuggggggggggacacaaaguuucaugcuagaugucgu
auguauuauaucuauaauauaaacauaucaaacucaa
204 AA032310 gangcucagugucguganauauaaaccaaaccuuagagccaucgcugaguauaaaaaaaa
ggaagauuuauauucngcaaagaguagccgaacuggacaaaauuacuucugaaagagaua
auuuungacangcauaugaagaucuucganaacaaaguucugaaunauuuauggcuuuguu
uuuacguaauaacaaauaaacuaaaagaaaacuaccaaaugcucacauugggaggagaua
cugaacuggagcuuguggacaguuuagauccuuuuucugaaggaaucauguucaguguu
c
ggccaccuaagaaaaguuggaagaagaucuuuaaccucucaggaggcgagaaaacccuua
guuccuggccuuaguguuug
205 M94087 Sequence below.
gccgguuunguuuugcgcucgugugucccuuuccucuuccccucccgcauuggcuugcggccaccauguucguauuagagg
cagcagugccuacggcagcguuauccuuugcauggcaucaacagcaccaggcucuacaacggcaacccccaccagccuaa
gccauggcgcucuucacgaaauccagcagcaguguugcuguaacggacaaagauaccuucgaguuaagcacauuccuggaa
uccagcanagccccacaacaugaccgagaugauucuuccuuuaacauucgaaguguuggcgugggacuuuaugucccccuucuua
ccagucggauuugggagcugagaaagccuaagucucuuagauaacuaucuggagguggccaagcacuugaaaccucaug
gguucuccagcgacaaggcgggcuccucggaauggccggcuauggaugauggcuuggccagugccucagacaccggcaag
gaggaugccuuuuccgggacauuauuguuauguuggagaaaauuugaucugaaauuaguuugacuucuuaugcucuguuucgaau
ggaugaccuggaaaccaugccagaugagcucuugaccacguuggaugacacauaugaucuuuuugccccucuaguccaaga
gacuaauaaggagcccccucagacagugaacccaauuggccaucucccagaaaguuuaauaaaagucgaccagguugccccc
uunacauucuuucagccuuuccccuguuccccagggguucugucuuccacuccagagcauuccuuuaguuuagagcuagg
cagugaagnugauaucucugaaauagacaggaagccugacucugcuacuuacaunuacucuanucccuccauguguaaagga
ggaagacacucccucugacaaugacaguggcaucuguaugagcccggaguccuaccugggcucuccccagcauagccccuc
caccuccagggccccaccagacaaucugccuucuccaggugguucccgugggucuccucggcccaaaccuuaugacccaccu
ggaguunguuugacagcuaaagugaagacugagaaauuggauaagangcuuaaaaagauggauucaaaacaagacagcagcc
acuagguaccgccagaagaagcgggcugagcaggaggcccucauggcgaguguaaggagcuagaaaaaaagaaugaggcu
cugaaagagaaggcagauucucuggccaaggagauccaguaucugaaagaccugauagaagagguccguaaggcaaggggg
aagaagagaguuccguaauaggguauuucaggugcuuuguuucuuguacauagucuuguguugcuguguuugcuguaauaa
auuauuuuguagugaaagu
206 AI847609 uuuuuuuuuuuuuuuauguagggaaguucauauuuuauuuguccagugacauuuuuua
caguugaauacaaguuaaaggccugcunugcacaccaaagccagguccuungggugguuca
gucaaagaauuuaaggccuccagcuggcucacaacagaagcggccacuccuuggcccuggu
uu
gggaacuuuuccaacuuuaaguucaucaauaaucucuucaauauccuugggugucagauc
cucauaguaguugucauuuauuugaaccaucggugcauuuacacaggccccuaaacauuc
cacuucuauaagagugaaaaguuugucagguguagucucuccaaccuuuauuccaa
207 AI853294 uunuunuuunuunuuunggggugaauauagccaaguauuccauuuanuaacaaaauagu
cuuagcaagggagagcucuguucaccccacaagaggccccgcagccgaggccggcccgaag
ccccagcgcuuucugcguaagaccuuggaguugaguugaagguguuugggauuaagacuuguau
u
aagucuuuaauccuagccaccgcaggaacccacggaaaccuaaugccagcuuuggcgauu
gcuuugcucaguuucuguugacaugggaagggagugcucugauccuagggcucccugaguc
c
ccagccugcccccaacagagcuccuaaaguugucuggucugcugacuugaggacugguaa
gcuuuggacggauccaucaagu
208 M33934 Sequence below.
ccucugcggcacgguccucggagcagcgcgguucucggagccacgcgucugucuuccuccguggucauaucggacuaccu
gauuagcggaggcaccucuuncgugccggacgacgggcucacagcgcagcagcucnucaacugcuggacggccucaccua
caaugauuuucucauucuuccuuugguauaucgacuucacuuucagaucagguggacuugacgucugcucuaacuaagaaga
uuacacuaaagaccccauuauuuccucacccauggacacugucacagaggcuggaauggccaucacgauggcgcuuacag
gagguanugguuucauccaccacaacugcacaccugaauuccaggccaaugaaguucggaaagugaagaaauacgaacagg
gauucaucacugaccccguguuuccuuagccccaaguuaucguguacgcgauuuuunuugaggccaaagccaggcauggcuucu
augguauccccaucacagauacaggccagauauggagucgaungguaugcaucaucuccucaagggacaungauunccuc
aaggaggaagagcaugaccgguucuuggaagagaucaugacuaagagggaagauuugguggucgccccugccggcgucac
ucugaaagaggcaaaugagauncugcagcgaaguaaaaagggaaagnugcccaungugaaugaaaangaugagcugguagc
caucanugcccauacagaccuaaagaagaaucgugauuacccccuggccuccaaagaugccaagaagcancugcugugugg
ggcagccauuggcacucaugaggaugacaaguauaggcuggacuuacuggcccuugcugguguggauguagugguuuug
gacucuucccagggaaacuccaucuuccaaaucaauaugaucaaauacaucaaggagaaguaucccagucuacaggucauug
gaggcaauguagucacugcugcgcnagccnanaccucauagaugcagguguagaugcuuuguagucggcaugggaauuu
gguuccaucugcaucacccaggaaguguuggccugugggcggccccaagccacagcaguguacaaggucucugaguaugcc
cgucgcuuugguguuccugunauugcugauggaggaauccaaaaugugggncauauugccaaagcnuuggcucungggg
cuuccacagucaugaugggcucccuccuggcugccaccacugaggccccuggcgaguacuucuucucagaugggauccggc
ugaagaanuaccgagguauggguncucuugaugccauauacaaacaucucaacaaccagaaccgauacuncagugaagcng
acaaaaucaaaguggcccaaggagnuncaggggcagngcaggacaaggggucuauccacaaguucgnuccuuaccugauug
cuggcauccagcauuccugucaagacauuggugccaagaguuunacccaagucagagccaugacguacucgggguuagcuua
aauuugagaagaggacauccucugcucagguggaagguggcguccacagccuccauncauacgagaaacggcuuuucugaa
aacagauccaguauaugccuugaauuuuucaauaaaaguuugggaaaaaaaaagugaaaaaaaaaaaaaaaaaaaaaaaaaaa
aaaaaaaaaaaa
209 X16202 gugugaugcagaacugaugucagggaaagcuggagccuunugcagacccugagcugcuc
acggcugagagcuggggucauuacccucaccuucauuuccuguaccuguccuucccagag
ccuccuccauccacugucuccancauggcnacguagcuuuuucuuuguuguccuuugagcu
uggccaucauncagcugugguaucuuungugaugaagagaaauagacacacaaguaaua
aagggcagagucugaguunuu
210 AI661431 gugugggugcagacuggggucagggaaagcuggagccuuuugcagaccuugagcuguc
acaggaggggaaggccaaagcaagaaugaaagucccccgccccguaucaccacgggcacu
cggggucacccucaggaacaugcagucucugcacgugaggaaaganacacgcagagaugg
acgagcacuuuuncacccuaaunaaauungaugcacuaaccacagaccccccu
aagggcagagucugaguuuuu
211 AI839109 uuuuuuuuuuuuuuuuuaaaaaaaaaaauggcaucuuuuauucaucaaucccuguuacac
acugaaauacaugcaucuuucuuauguuacuuagcaacguccuuucuauccuuucaccca
uaaaucagucugaugaauucaucuuuaaauucaagaaguuuuucuuuuugaaacgcuacu
uacaunuuaungucucaauaucaaagccaaucuagagauuuauucuuccuacaggugaaa
uagauguuaauacgggaacagucaguacauguucaagaugacaucaaaguuaugcccuaa
gcagauauuucaaggcaauaucaugccacuagcucugagacucuaaguaucacugauagu
acuaaaagguagaagucagcuncaaaaacacacucuugcaauggacacugcucaugaugu
cuaagauuguucacucccacagucaugauuucagaugcacaguuuuuuuugcuuuccuga
gcauucggunugac
212 AI849135 uuuuuuuuuuuuuuuuuaagagugucaccaaagcuuuauuuacaugcgucaucaucucuu
uuacaaacuagauuaugguuuuaaauggaauacacaggcaauaucuacaaacgccacggg
aaguacgcaccuccauuccaccgggaagaugcagauucccaaaucaaacugguuuugauc
cuugagaagaaaggcggcagagcuaacucacggcagcguaugguuagacaagguccucag
uacccagaaugcagcaggauugcgucugccucaaaccagacgaccaacugcugcaggugu
uuaaacauauccacacgccacacgaaauucuaguuuaugugggauagaagcaagaaaaaa
aaaaaaccauggcgccucgugccg
213 M32459 gguccagauaguaaacugcucccuuacaucuccuuaaauauaaaguaaagaaaaagaaaa
aacucaguucggguaaccaaguucaacaaguaauccuuggggccgcugugguaucgccaa
aaucuacauaguaucucuuauuaaaauguuuugacgaaaauguaacaauuacgguacuua
augguaacaauguggcugaggaagcaauaguuaacaaagaagagcuaagcuaugcaacaa
accagauuucuauuggucacaaauuugaaguugagaccuguuauccaauuaccaaguacu
uccgcauacaucaucauaggcauuugaagauuucaaccaaucaggagcauguuccuucua
uaaaggaacccagaaccuaaccucugcauuuccuauuucuuuguagaaauggcucguacg
aagcagaccgcucgcaaguccacuggcggcaaggccccgcgcaagcagcuggccaccaag
gccgcccgcaagagcgccccggccaccggcggcgugaagaaaccucaccgcuaccguccc
guucaccguggcuucugcgcgagauccggcgcuaccagaagucgaccgagcugcugauccgc
aagcugccguuccagcgccuggugcgcgagaucgcgcaggacuucaagaccgaccugcgc
uuccagagcucggccgucauggcucugcaggaggcgagcgaggccuaccuugugggucug
uuugaguuacaccaaccugugcgccauccacgccaagcgugucaccaucaugcccaaguuac
auccagcuaucccgccguauccgcagcgagcaggcuuaauaggcacgcuuucuacacugg
cacguaaaccaaaacggcucuuuuaagagccaccuccauuauccaccaaagaugcuugaa
guacaaguugugagaguuuucuaggguuuccuauuauagccuuucuugacaangungca
ccacccgacgaagcagucugag
214 AI841389 uuuuuuuuuuuuuuuuuggacuucugcggcuuuuauuuuugcauguaaaccacuggggg
g
agggggaucuugauggugggcacccuagagauuacacuggaguuccgagggcuccagaca
cuagcugggaagucaggugacagaaacaaugauucagaccaaucacaugnuugcaaaacu
gauucuccagcagggauncugguggucaauuguggaugccuaaggaagcagugacauggg
aggggcacgcacugggcuggccuugagcugcugggaugacaucagggauagaggaccuag
cagcugguggcuccagggaucuccgguccaugcuuuauuuggccaggggguuccugaagg
accugccagcaaacuuggcuuugcugcccagcucuuccucaauucugaggaucugauugu
acuu
215 X03039 Sequence below.
auucuaauugaucaugucugcgauuucaggauucuauccagancaauggccccgacggaug
gagaguaacuggaacgagauuguggauagcuuugaugacaugaaucucucagagucccuccuccgugguauuuaugccua
uuuuuugagaagcccucugccauccagcagcgagcuauucuuccuuguaucaaggguuaugaugugauugcucaagccc
agcugggacugggaaaacagcuacauuugccauaucaauucugcagcagauugaauuagaucuaaaggccacucaggcuu
ugguucuggcacccacacgugaauuggcucagcagauacaaaaggugguuauggcauuaggagacuacaugggugccucu
ugucaugccugcauugggggcaccaaugugcgugcugaggugcagaagcugcagauggaagcuccccauaucaucguggg
uaccccuggccggguguuugacaugcuuaaccggagauaccugucccccaaauacaucaagauguucguacuggaugaagc
agaugaaaugunaagccgaggguucaaggaucagaucuaugacauauuccagaagcucaacagcaacacacagguagunuu
guugucugcuacaaugccuucugauguccuugaggugaccaagaaauuuaugagagacccuauucggauucuugucaaga
aggaagaauuaacccuggaggguauccaccaauucuacaucaauguggaacgagaagaguggaagcuugacacauugugu
gacuuguaugagacgcugaccaucacccaggcagucaucuuuaucaacaccagaaggaagguggacuggcucaccgagaag
augcaugcccuuagauuucacuguuucugccaugcacggagauauggaccaaaaggaacgagaugugaucaugagguuaguuc
cggucuggcucuagcagaguauuaauuaccacugaccuguuauccagaggcauugaugugcagcaggucuccuuagucau
caacuaugaccuucccaccaacagggaaaacuacauccacagaaucggucgagguggucgguuuggucguaaggguguggc
uauuucauggunccgaagaagacaagaggacucuucgagacauugagacuuucuacaacaccuccauugaagauuaugcc
ccucaacauncugaccucauuugagaugcuguccugcgaccuggcccuagcccagauucaguccugauguggggcuaa
ggaagagcuggaggggggaggggagggagccaagggauggacaucuuguuuuuguuuuggcuuuuuuuuuuuuuuuguu
ucaguuuuuuucucuaugaauaaaugucacuuuuugaggc
216 AW049795 uuuuuuuuuuuuuuuuugccaggauauauuuauuacugaaaguacaagcaacugagguuu
acccugggaacacccacaaugaaacguguaucuucccuguuucucagaugcugccuccuu
ccacagagugaguunucguuuaaaacucauaaugaggagaaggcagggggcuccaccccu
uuccuauucaaucugaagacugaauugggcuacacugggauggaaauuucaauugcuaca
ggucagugucaaccaaggguucgugugucaggaacucuggcugguaagaugacacaaagg
cuucaugcugaagcucagggagguccagggagccuggcagaauggaaucaucauggucau
caucaaacaucuaugucuggaaggcuucaaggcucauaauugcaucauucucuggcaguu
ccugagagagcugccccuuccuggguuugcacgcaucaaauuucacccacugguaauuga
cacaguuuugagcuucgggacaacucunaaucagguuguggaugguuggaugagaaaacc
caaagaagucggcaccgcauga
217 D87691 Sequence below.
auuguaacagaagaaggaaaggaaaagaaaguuaacauugacunugaaccuuucaaaccaauuaauacaucauuguauuug
ugcgacaauaaguuucauacagaggcucuuacagcguuacuuucagaugacagcaaguuugguuuuuuguaauagacgg
aaauggugcucuuuuuggcacgcuccaaauaaacaccagagaaguccugcacaaauucacuguggaucucccaaaaaaacac
ggcagaggaggucaaucagccuugcguuuugcccguuuaagaauggaaaagagacauaacuauguucggaaaguagccgag
acugcugugcagcuguuuauuucuggagaccaagugaauguggcugguuugguuuuagcuggaucagcugacuuuaaaac
ugaacuaagucaaucugacauguuugaccagaaguugcaaucuaaaguuuuaaaauuaguugauauauccuaugguagug
aaaauggauucaaccaagcuauugaauuaucuacugaaguucucuccaacgugaaguucauucaagagaagaaauuaauag
gacgauauunugaugaaauuagccaggacacaggcaaguacuguuuuggaguugaagauacacuaaaggcuuuggaaaug
agagcuguacaaauucuaauagucuauaaaaaucuggauauaaugagauacguucuucauugccaaaucacaaaagauag
aaaauucucuauuuaacuccagaacaagagaaggauaaaucucacuucacagacaaagagacuggacaggaacacgaacuga
cacaagaaggaucacaguuuguaaaaggauuugguggaauuggagguaucuugcgguaccgaguagauuuccagggaaug
gaguaccaaggaggagaugaugaauunuuugaccuugaugacuacuagguagucgacauggguccggcaaccgugccuca
cccuccagcauucaacccaaggagcauacccgugguggaguccaacagaucccugccunacaauuggagcauuuccagaacu
uaauccgugagcauuggauacugaaaagaaaagugaaacaaaaccagacccaacccuacacuuugguuugucuuugguguca
gcgcagcagccgacaacuaaguu
218 AI117211 cagaggagucauuguugcuguggugacuuuugugaugaagagaaggagaaacacagcgua
agccagcugccuggaguggacuaagugacagacaaugucuuucacacaucuccugugacau
ccagagcccucaguuuuucuuuagucauguaucugauguuucccugugagccuaugggucaa
agunagaacuguacaacccaaccugcccugcacacagaacccugucccugcacugcccu
ggguucccuuccacagccaaccuugcugcuccagccaaacacugggcgacaucugcaucc
ugccaguuaccaaugcugcccugagcugcagcugcucacuuccacacugagaguaagaaucu
gaaugggacuagauucuuaacauccugaccgaggguugauuucuuguuaauuucaugga
uugagaauacuuagaguuuugguuugucuugauuuuuuuucaag
219 Y00520 ugaauaaaaacgaggagccgaagauucuagggggcuacagcugcgcuuuugcagcacuga
acaugguuccggguacucaagauauugcguuuguguuuggagagguguagauuguagauu
ccagccgagaagaccaggaaaagauaaggauaaagaaugucauauaucucaggagcuaga
ucacuucccgaugaacaaguaagaauugccucaacaaaaauggauggaauuggaccgaaa
aaagccauucagcuucguuaucgauuagguaucagugggaacaucaagaugaaugaguua
acuaaguaucagaucgaccaaauugaacaaaugauagcucaagaucauguuguucauugg
gaauugaagaggagagaacgagcagacaucaaacgauuauuucuauuucucguuaucgu
ggaauucgucaucaagauggaucgcccuuacgcggucaacgaacucauacuaaugcaagg
acugcucgcaagcaaauucggaaaugaaagaaggcuaccgaaagaacaagcaacggauuu
cgcgcucaucccuugcuuagcgcauacguuuuucuugcuccuugguacuugucugauucaa
ucacacuguucauuaguucacuugauuuuucguucgaugucuugaaccgcuuacuaauca
cguauacguauaguaggcccccuucgccacuccacgucuggcccgucuuggucucgcuca
cuucuccgccuaucguaucggcucggcuucguccgucaagcgacagcuucugccuuoga
cggcuaucacuaucgcucaugacugguaguacucuauguaguagucggccuuuguuaagcu
u
220 AA638002 uauaaccauguuagaagcggaaguuggccugaaaaccugaggcuuaggcuucauagcugg
gcuguagauuggauuuaaacccaguuggagugcaaagucauggugugcucaaggugauga
cagugaacagaguaug
221 Z22661 caugggccuccugagaga
uccuuagauccagguuagugcauaggaaaguguccccccacuaccuacagcuaagggauu
gggguggugggaucaugguggagggccguggugaauacuagcgaugucccccgcuacccg
ugcgucugccuccagggugccccuccaaccaggaugaggcucuucaucgcucuuccuguc
cugauuguggucguagccaugaccuuggaagguaagaaagagccuuggaagguaagaaag
augcuuuaagugugaaguuggccuugugccugcggcccaggcuuagaagacccucgagg
agggcucugaggucccuuucugugucaucauuccacuaccgcccucccaucgucccccau
cccaccugccaggugccuuauuuuuugugucauagugggugcagaaggaggcaauacuguc
cagaaaagacgcaguaaccaaugaccuaggauaccacccuuuagaauuggcuaaucuucc
uagaaggggcggacgguaaaaacaaggaggugagaggugcaguaaaaucaaguguccaau
acccucccccaugcuaaugaguuugcucgcaacccucucgcggcaggcccagcccccgcc
caggcgaccccagauuuguccggaacauuggagagcauaccggauaaacugaaggaguuu
gggaacacuuuggaagacaaggcccgggcagccauugaacauaucaaacagaaggaaauu
uugaccaagacccg
222 X99644 Sequence below.
cagcgccuggggcgcggcgggcgucggcccaggagacgcguggcggcgcucggccucgcggcaucggcuggcc
guuggcggcgagcgcacuugcgccugcgcagcgggguccgugccccuccuccccugggcggcccccccacccccccggcgg
caugugaauggcggccucggcggcagcgacugcagcggccucggccgcgacggccgccucggcagccucuaguagcccag
ggucgggcgagggcucggcgggcggugagaagcguccggcugcuuccucagccgcggcggccucugcagccgcgucgucc
ccugcggggggcgguggcgaggcgcaggagcuucuggagcacugcggcgugugucgcgagcgccugcggcccgagcggga
uccucggcugcuuucccugucuacauucggccuuucagugccugccugguuccccuucuacacccgccgcagcgaauaauucggg
ggauggcggcucggcgggcgacggcgcuaugguggauuguccagugugcaaacagcagugcuacuccaaagacaucgugg
agaauuauuuuaugcgugauaguggcaguaaggccucuucugauucccaggaugcuaaccagugcugcacuagcugugaa
gauaaugccccagccacuagcuauuuuguggagugcucugaaccacuuugugagaccuguuuuggaggcucaccagcguugu
aaaauacaccaaggaccacacugugcgcuccacaggaccugcuaaaacucgagauagagagcgaacagucuacuguaaugu
gcacaagcaugagccccucgugcuguucugugagagcugugacacacucaccugccgcgacugccagcucaacgcucacaa
ggaccaucaguaccauuuuuuuguuaauuaugcagugaggaaccaacguaaacucuuggcuucacuggagaaacgucuugggg
acaaacaugccacacuuucagaaaaacaccaaggagguucgaagcucgauccgccaauuguucugaugugcagaagcaagugca
gguugaugucaagauggccauucugcagaucaugaaggagcugaauaagcggggucgaguucuggucaaugaugcccaga
aggugaccgagguuucagcaggaacgucuggagcgccagcacuggaccaugaccaaaauucagaagcaccaggaacacauuu
ugcguuuugccucuugggcucuggagaguugauaacaauacagcucuucuugcucuucuaagaagcuaaucuauuuccagcug
caucgggcccucaaaaugauuguggauccuguggagccucauggugagaugaaguuucagugggaucucaaugccuggac
caagagugcugaagccuuuggcaagauuguggcugagcguccugguacgaacuccacagguccugggcccauggcuccucc
aaaagccccaagcccucuaagcaagcaagguucuggcaguagccaacccauggaaguacaagagggauauuucuuuauguc
agaugaucccuauucaagugcagagccgcauguaucaggcaugaagcggucccgcucuggugagggagagguaaguggcc
ucuuaaggaaggugccacgugugagccuugaacgccuggaucuggaccucaccucugacagccagccaccagucuucaagg
ucuuuccuggaagcacuacugaggacuacaaucugauuguuauugagauuggugcugcugcagcagcuuucuggucaggcu
gggacugugccaccaggagccccuggugccccaccccuuccuggcauggccauugucaaggaagaagagacagaagcugcu
auuggagcucccccggcugcccccgaggguccugaaaccaagccuguguugaugccucugacugaagguccuggugccgag
ggaccucgucuagcuucaccuaguggcaguaccagcucaggcuuggaggugguuugcuccuuuagguuacuucagccccagu
aagugauccagguauuccuggaugacaaugccacuaucuugccgaguucugccagaaaccagguaaccuggucauguguaacca
gugcgaauuuugcuuccaccuggauugccaccucccugcccugcaggauguuccaggggaggaauggaguugcucacucu
gccacgugcucccugaccuaaaggaggaagauggaagccucagccuuugauguuagcagauagcacugguuuugguagcuaaac
uucucaccagccaaccaacggaaauguugagcguguucuccuggcccuguacuaccaugaaccaugccguucccuugcaucagc
agcugucaccuccuuauagcuccccccaguuaguuugcucaagauuuugggccgcauguucaaacauuuucaacaagcuuuacug
aagacaaggcagauguucaguccaucaucggcuuugcagcgcuucuuugagacacgcauaaaugaugccuuuggugacacca
aguuuucugcugugcugguagaaccaccaccauugaaccuucccagugcuggccuaaguucucaggagcucucuggcccug
gugauggccccugaagcuggggcucuuguggucagcccaguccagcucuggucucuguauuuucaccccauacccugucc
uauaguggccugacuccuauucuugcuauccccauucguccccucaguucccucuuucacaaaaugguauuuacuucuaugga
uuuaauaaaaacuucacugagucaguuaaaaaaaaaaaa
223 AI843895 uuuuuuuuuuuuuuuuuaaaaauaauuucauuuuuuaauauucuguacaaaauuucucaa
ccuaugaaaauaaaguaaucaaaaguucaaaguaguacauaggccugcccuggagccaggc
ccagccggaucuacacuauguacaggucucccagggugagccucagcuagggaaaagcca
cuaaggugccuacagagcaagauuggugccaucgguuccagugcagccucugcaauuuccag
aucugccacuaaaggucggcaugauccugauugcuuaucaggcucacccucuggaagacc
acagccaaugacaaagguccucaagggaaagcuuuggggucuagcuggaagugacggugg
guccgccgcccaacgcaagagcaucugcuggcaguccagcaguaaccggugaucgccaa
224 M38724 uccgucguaaccuguugaguaacuauggaagacuauaucaaaauagagaaaauuggagaa
gguacuuacggugugguguauaaggguagacacagagucacuggccagauaguggccaug
aagaagaucagacuugaaagcgaggaagaaggagugcccaguacugcaauucgggaaauc
ucucuauuaaaagaacuucgacauccaaauauagucagccugcaggaugugaucaugcag
gacuccaggcuguaucucaucuuugaguuccuguccauggaccucaagaaguaccuggac
uccaucccuccugggcaguucauggauucuucacucguuaagaguuacuuacaccaaauc
cuccaggaaauuguguuuugccacucccggcgaguuuaucacagagacuuaaaaccucaa
aaucuauugauugaugacaaaggaacaaucaaacuggcugauuucggccuugccagagcg
uuuggaauaccgauacgaguguacacacacgagguagugacgcugugguaccgaucucca
gaaguguugcugggcacguucguuacuccacuccgguugacaucaggaguauagggacc
auauuugcagaacuggccaccaagaagccgcuuuuccacggcgacucagagauugaccag
cucuucaggaucuucagagcucugggcacuccuaacaacgaaguguggccagaagucgag
ucccugcaggacuacaagaacaccuuucccaaguggaagccggggagccucgcaucccac
gucuagaaccuagacgagaacggcuuggauuugcucucaaaaaugcuaucuaugauccu
gccaaacgaaucucuggcaaaauggcccugaagcacccguacuuugaugacuuggacaau
cagauuugaagauguagcccucaggauggaugucccugucugcuggucguaggggaaga
ucg
225 AW122989 uuuuuuuuuuuuuuuuuacuaggcaaagaauuuuauuaacccuuuccaaacuuuauuccc
aggcuucuucagcuuuauuugccgcaaagaaugaauuagguauagcgaaaacugaaaaga
gcugcaguguccgggggcuugggcuuaaaaauauuagagaucuagauuuuaucagaucca
uaauaaacaaaaaaauuuuuuaaagcagucaaugauauaaaauagcagcaccuguanuuc
ugcaaguaucaccuucuucaaaauuugcuucaauucaauuuugccucauucuauagaagcu
caucaaaauucuccaccagaucuggaacuucaucaucaucauccucuccaguagcaaggg
gugcauuaccauccacagauuguuugggcagagcuucagccagucuccuuaaacuaguca
ggucugucugcaccaagcuuuugaggaugcugggaagcauuuugucagcugcuuugc
226 AI844810 uuuuuuuuuuuuuuuuuuuucaugcuugccuagggauggggaauagaucucaauaaa
a
acauacaguaaaaacaggggguggggagggggaaggcuuaucauguacaauguuuaaacu
acaauagugauguaccuuaauuacuuccaugcacacaagucuaacauuacaaguuuuuaa
aaaauaaacaccauuaagacuucuaggagcauuuuauaauaaauuccuaauuuuuucuuu
guagauagaucaagcaccuccaaaauacagauuccuauacacagugagcacuuuacuuaa
cguacauggacagccucagucugcagacgucuuggaucagcuuggcaggcaacauacc
auagugccaaauggaaagaagagcaguagcaauuaaacuuaaaacuaaguuaacuuuuu
aauuaaauacagaaaauauacugauuugcuaaaaauaaauaagaugugauguauuuaaca
cuucacuauaaagaaugaacaccaugacauccucgugccg
227 AA940430 agaagaaggaggagugggaccgcaagcaugaggaugcuaguagggaguaugagaaaggca
ugaaauguaugaaggaggaagaggggacucauucaaaaagggacaagucuaagaagaaaa
agaaaguaaaagcaaagauggaaaaaaaguccacuccuucccggggcucgucauccaagu
cuucauccaggcaguugagugacagcuucaagagcaaagaguuuguguccagugaugaga
gcucuucaggcgagaacaagagcaaaaagaagaggaggcggacgaggacucugaagagga
gcuaggccaguaccccaccaaacucagaggacucugccucgagaucugaugaauaaaggag
ggaauucccaccccgucacagcuccagucucucacauaguccuuggauucugugccauc
gaguaacugcucuugguggcuuccacugcccugaggcuuugagggaag
228 M38381 Sequence below.
aucgucguaaucguuugcagacuucucgccgucgccuuguaagcuuugucuucgccuugcaagcuuugucuucaggguug
gaaagauggagacauucaaagagaacuuacuguccugacugggauaaaagagacugggauuauggaacauggagaagcagca
gcagucacaaaagaaagaagagaucacauagcagcgcccgugagcaaaagcgcugcagguacgaucacuccaaaacgacaga
cagcuauuaucuggaaagcagauccauaaaugagaaagcuuaucauagucgacgcuauguugaugaauacaggaaugacua
caugguucuacgagccagggcaucccuauggagaaccuggaagcagauaccagaugcauaguagcaaguccucugguaggag
aaaagaucgaggaguguagaggaugaugaggagggucaccugaucugucagaguggagacguacuaagugcaagauauga
aauuguugauacuuuaguuugaaggugcuuucggaaaagugguggaaugcaucgaucauaaagugggagguagacguguag
caauaaaaauaguuaaaaauauggauagauacugugaagcugcucaaucggaaauacaaguuuuggaacacuugaauacaa
cagacccccauaguacuuuccguuguguccagauguuggagugguuugagcaucgaggucacauuugcauuguguuugaa
cuucuuugggcuuaguacuuaugauuucauuaggaaaacauuuuuucugccguuucgaauggaucauaucaggaagauuugc
auaucaaauauggcaaaucuguaaacuuuuugcauaauaauaaauuaacucauacagacuuaaaaccugaaaacaucuuauu
ugugaagucugacuacacagaggcuuauaaucccaaaaugaaacgugaugaacguacuauaguaaauccagauauuaaagu
gguggacuuuggaagugcaacauaugaugaugaacaccacagcacauugguaucuacaagacauuauagagcaccggaagu
uauuuuagcccucgaguggucacagccaugugaugucuggaacauaggauguauucuuaucgagguauuaucuuggauuua
caguuuuuucgacucaugauagcagggaacauuuagcaaugauggaaaggauucuuggaccacuaccaaagcacaugauac
agaaaaccaggaaacgcagauauuuccaucaugaucgauuagauugggaugaacacaguucugcuggcagauauguuucuc
agcgcuguaaaccucugguagggaguuuaugggcuaucucagggaugccgaacaugagcuucucuuugaccucauugggguaaaua
uuggaguaugaucccgccaaaagaauuacucucaaagaagcccuaaagcauccuuucuuuuacccacuuaaaaagcauacgu
gauuuauaaacacagugcucugaaaggaaucuuacagacuguaucagucuagcuuuuaauuaaguuauuuuguauagcuu
aauuuguaaaacauuuuauguuuuuuagaugcuuuauuaaauacauggccaaaccaaauaacaucuuucaguaauuauaga
augauuuauuuggaauaaaauuugugcuuaugaauguaaaaaaa
229 AF014371 ggacucgcgacaagcguccucagcgcgaagaggcggacucuugaguccucgccuugagccu
ugcaucugagaaguuccagguacuuuguacaacugcaucccagaaccuguauguuuucag
caccuuuauaagugauggcugccaucaggaagaaacuggugauuguuggugauggagcuu
gugguaagacaugcuugcucauagucuucagcaaggaccaguucccagaggucuaugugc
ccacgguauuugaaaacuauguagcggauaucgagguggauggguaacaaguaguguug
g
cuuuaugggacacagcuggacaggaagauuaugacugccugaggccucucucuuauccag
acaccgauguuauauugauguguuuuuccauugacagcccugauaguuuagaaaacaucc
cagaaaaauggacuccagaagucaagcauuucuguccaaaugugcccaucauccugguug
ggaacaagaaggaccuucggaaugacgagcacacgagacgggaguuggccaaaaugaagc
aggagccgguaaaaccugaagaaggcagagauauggcaaacaggauuggcgcuuuugggu
acauggaguguucagcaaagaccaaaaauggagugagagugguuuuugagauauccacaa
gagcugcucugcaagcuagacgugggaagaaaaagucugggugccucaucuugugaagcc
uugugaacgcaucucaugcguuuuaauuugaagugcuguuuauuaaucuuaguguauga
u
uacucgccuuucauuuaucuauaauuuaccuaaga
230 Z30939 uucaagaccgaccugcgcuuccagagcucggccgucauggcucugcaggaggcgagcgag
gccuaccucgugggucuguuugaggacaccaaccugugcgccauccacgccaagcguguc
accaucaugcccaaguuacauccagcuggcccgucgcauucguggggagaguugcguaaauu
aggguagugaaugaauuuauaccccaaagacucuuuucagagccacccacauuuucuaua
aaaggcuguauaucgauaagcuuuuauaaaccccacucagcaacucc
231 U28208 uuaugugauuaaaaaaauucaacuugguuauuacuuaacuuaagggccuuggugcuggugcu
uugccugauguugguaaaggugcagcagaagaaucaauugaugaaauuauggagcauaua
aaagauagccauaugcucuuuaucacagcagggauggguguuugguacuguuaacauugugcu
gcaccgguaauugcaaaagcagccagagaaacaagagcgguaguuaaagauaaaggagca
aaagaaaaaaagauacugacuguuggaguuguaacuaagccguucgguuuugaaggugug
cgacguaugcgcauugcagagcuuggacuugaagaguugcaaaaauacguagauacacuu
auugucauucccaaucaaaauuuauuuagaauuugcuaacgagaaaacuacauuuugcuugac
gcauuucaacucgccgauaauguucugcauauuggcauaagaggaguaacugauuugaug
aucaugccaggacugauuaaucuugauuuugcugauauagaaacaguaaugagugagaug
guuuaaggcaauuuauuguuuacuggagaagcagaaggauuaagauagggcaauuagugcugca
gaggcugcgauaucuaauccauugcuugacaauguaucaaugaaaggugcgcaaggaaua
uugauuaauauuacuggugguggagacaugacucuauuugaaguugauucugcagccaau
agagugcguuuaagaaguggaugaaaaugcaaauauaauauuuggugccacuuuugaucag
gcgauggagggaagaguuuagaguuucuguucuuacaacuggcauuugauagcuguaacgac
aauucaucuguuaaucaaaacaagaucccagcagaggaaaaaaauuuuaaauggccuuau
aaucaaauuccaacauuagaaacaaaagaauaugcuucaacugag
232 AV218217 ugaucaggucacauuccggugccuuccacccccuauggcacgggcgccccgccuugccau
accacagcucccuccaggcuuagaccuggcuucaccgcauuucaggugcuauaccccccc
cugcuuuuccccccauugcccuuaaaugccccucggccccuccauccccccggaacaggg
uggcacuugccacucucaggaccaccuugccaaggagaauaaaccgaauccuguugcu
Thus, the transcripts identified in this Example, the proteins they encode, and the pathways in which the proteins participate contribute significantly to HF stem cell activation. Accordingly, anagen can be induced by activation of these transcripts, proteins, and pathways.
Example 9 Molecular Pathways Activated During Induction of Epidermal Cells to Differentiate into HF Stem Cells The gene expression pattern of HF stem cells was analyzed as described in Example 8 and compared to non-bulge basal keratinocytes. 157 genes were differentially expressed in the HF stem cells, as assessed by microarray analysis and quantitative polymerase chain reaction (qPCR). A group of selected genes with increased expression in HF stem cells is depicted in Table 4. A group of selected genes with decreased expression in HF stem cells is depicted in Table 5.
TABLE 4
Genes up-regulated in HF stem cells. Numbers in parentheses are the fold increase
as determined by quantitative real time PCR.
Gene Name/
Protein
name/ SEQ
GenBk Fold ID
Acces #. incr. Sequence No.
Cell surface proteins
Cd34/Cd 34 43 uuuuuuuuuuuuuuuuucacucaucacguuuauucagaagagaauaca 233
antigen (189) cccaauccucucaucucuggaaaguuuuguuccuagccaucauuaagau
AI847784, caggaccccuauucuccccuuaaccccaggagauaagcuuauagucuu
AI173145 uguagattauucugaaccucugaucacaaaggguuauaaaauagugaagg
gguuuggacuaggaaaggcacagacugaaaggaaucugccaggggacug
aggccacagcucccccauugagucagaggaagguuggaagucacuuuauuuu
auagaaggccaagggccucagagcaagaguauuccuuugaagagcuca
Calcium-related
S100a4/ 35 ugguggagcaggucucaggaaucucuucgcuucagcuucaaucauggcc 234
S100A4 (144) uguggucuggucgccagcaaccugaaucucaaaccuggggaaugucuca
(mts) aaguucggggagagguggccucggacgccaagagcuuugugcugaacc
X15986 ugggaaaagacagcaacaaccugugccuacacuucaauccucgcuucaau
gcccauggagacgccaacaccauuguguguaacaccaaggaagauggga
ccuggggaaccgaacaccgggaaccugccuuccccuuccagcccgggag
caucacagaggugugcaucaccuuugaccaggcugaccugaccaucaag
cuucagacggacaugaauncaaguuccccaaccgccucaacauguuaggc
caucaacuacauggcggcggauggagacuucaagauuaagugcguggcc
uuugagugaagccagccagccuguagcccucaauaaaggcagcugccuc
ugcu
Transcription Factors and related genes
Id2 helix- 11 gugguucuucggcgccagguucgcccgcuucugcccuuagguaacauu 235
loop-helix (25) cucuaaacugcguuucucucccaaucuuuugcaggcauuuggggacuu
protein uaucuuuucuuuuuacutuucucupuuucuuuugcacaaaaagaagucu
AF077861 acaagaucuuuuaagacuuuuguuaucagccauuucaccaggagaacac
gugaauggaccuuuuaaaaagaaagcguuaaggaaaacuaaggaugau
cgucuugcccaggugucuuuguucuccggccuagacuguugauaccguua
uuuaugagagacuuucagugcccuuuuucuacagauggaagguuuucuuu
auauacuauucccaccauggggagcgaaaagguuaaaaaaaagaaaaaaa
ucacaaggaauugcccaauguaagcagacuuugccguuuucacaaaggug
gagcgugaauuccaggaggacccaguauucgguuacuuaaaugaagucu
ucggucagaaauggccuuuuuugacacgagccuacugaaugcuguguaua
uatauuauauauaaauauauauauauugauuugaaccuuguguuacucuuu
aauuagaguuuucuuguauaguggcagaaauaaccuauuucugcauuaa
aauguaaugacguacuuaugcuaaacuuuuuauaaaaguuuaguuguaa
acuuaacccuuuuauacaaaauaaaucaaguguuuuuuauugaauguuga
uugcuugcuuuauuucagacaaccagugcuuugauuuuuuuuaugcu
auguuauaacugaacccaaauaaauaccaguucaaauuuauguagacug
uauuaagauuauaauaaaaugugucugacaucaa
Id4 4 cgaugaaggcggugagcccggugcgccccucgggccgcaaggcgccguc 236
AJ001972 (12) gggcugcggcguucggguuagcuggcgcuacgcugccuggcggagcacgg
ccacagccugggugacucggcagccgccgccgccgcugcggcggccacg
cgcugcaaggcggccgaggcggcggccgaugagccggcgcugugccugc
agugcgauaugaacgacugcuacauuucgccugcggaggcucgugccuac
caucccgcccaacaagaaagucagcaaaguagagauccugcagcacguu
ucgacuacauccuggaccugcagcuggcgcuggagacucacccugcuuu
gcugagacagccgccaccgcccgcgccaccucuccacccggccggggcuu
guccagucgcgccgccgcggaccccacucaccgcgcucaacacugacccg
gugagaagccuuggcgggcacccugggcaucgcgggaaagguggcggg
gcggcgagauacggguggucuugcuccucucagggaaugacagccgcu
ucucccaucuccaccgagagccgccugcugggcauggugauuccacuuggu
cccuuugagccgagggcgguugggcuuggagcccugcgucuccggagugu
cccuugcaucacaggaggcuuccccagcuucgggcucggguggggacuc
uacuucaccuugccuaguuuuuccaggacgucuccugggugguggcgacac
ugugauaugcgcacucuaaccgcuuuuccccuugguguuggguugcug
uuccaggccggcugccguugaacaagcaagauacagcauucucuugccgcu
Peg3/ 12 Sequence below. 237
Paternally acuagucucgaccauguaccaucacggagacaacaccaacagugacaugaacagugacgacgacauga
expressed gccgaagugggagagaaaccccacccccucgaccaucucaugcuuuuggcagugagcgagaccuggag
gene 3 cgcaggggcagaagcagagauguggagccucgagaccgcuggccauacaccaggaaucccagaagcag
zinc gcugccucaacgggaucuuucucuuccugugaugucaagaccacauunuggacuggacagaaaugaug
finger acaaacguuccauagauuauugagucucgaucccaggauaccgagucauaccagaauguuguggaacu
protein caaagaggacaagaagccucagaauccaauucaggacaaccuggagaacuacagaaagcugcucucgc
AF038939 ugggaguccagcuugccgaagaugaccgacacucucacaugacacaaggccacucaucgagguccaaga
gagcugccuacccaagcaccagccaaggucuucaaacccaugccugaggccaaaaagccaucccaca
ggcgugggaucuguaaggacgagucuucuccuccuccaagguuccccaggccuaaugauaacu
ggaaggacaguuccuccagcagaagagagucagugauccaggagaggguuuuauuuaauuggagcgc
auuuaggggcggcuuccgguucaacgcagaccuggcuuccauuaauucagagcucuagaaauuga
agaggcguuaccacuuugauucugaugagcgggguucgggccaugagcauaaaagcugugugagg
aagaagccuuuugaguguggugcugagaugagacaggcuaugagcaugggcaaccugaacagcccuu
ccuucucugagucgcagucaaucgauuuuguuggccaacccauacguguguuuaugagugcgggagg
caguncaguuuucaucucugaguunguugagcaccagaucaugcacacuagggagaaccucuaug
aauauggagaguccuuuauucanagcguuggcugucaaugaggugcaaagaaguucagguagggggg
aaacgcuuugaguguaaggaauguggagaaaccuucaguaggagugcugcccuggcagagcaccgcc
aaauccaugcuagagaanaucuuuucagaauguauuagaucaggauugaugaggagaccauca
ugccuagcccgaccuunagugauucugcagaaaauguauuggcaaagauaaguucuauaagugc
aaggugugcaauagaccuuucugcacaguuccgcccugauuugagcaccagaaaauccaugguag
aggcaacucagaugacagagauaaugagcgugaacgcgaacgugaucgucuacgugcacgugcacg
agagcagcuuugagcgcgaacgugaacgggagcgugagcgugagcuuggggaacccuuucuuuacc
uguccaaacuucaauaaguuncuaagauuguacaggaaaaacaaaaucuuaugagugcaaagugu
guauggaaagcuuucuucaucucucaucccugagggagcaucagaaaauccauacuagaggaaa
ucccauuuugaaaauaagagcaggaugugcgaggagaccuuugucccuagcagucucuccgacggc
gccagaaaacuuacagagagaagcuuguucgacccnaacaaugccagggaugcacugaugggaaac
ucagacuccagcgagcaucagaaaaaccuuuucccgaaguuaacuucuungagggcagaggauuu
gauuaaacccuucguuuuaaucucagaagagucauacuauaacaagaccaccugaaaacaaagacg
augacaagccguucacaaucagugucaacccuaaugacaagcugaaacuccccaucauggaaaau
ggcucccagggcaaauccugugagaggucuguuauucauagcuugggcuccgcagaagcucauuaau
uagucauuuguggacugguuguucaguaaaccaauuaccaguggcagauuucuagcacccagagc
ucaauucagcauuuacuaccccagagcacacucuggaggcaacaccuaugaaggaaaagaauacaag
gacucuaucauccauagcuugccagcuccucgaccucugaaacgucauagagcaaaugaccauauuc
aaugugaugaggggggagaauccuccauuuauaucccagauauuuauuaauaagggaaggaagau
uccugccagagaagaugcuuuaugaaggaaguagcagcagcaacuaccacacaccaaauguaucccg
ugcugaaccuccaaaucuuncuggagagucccaugacucuaagcaggauaucacgunuucaguucccag
cucaaguguucgugaacaccagaaagcucgugccaaaaagaaguacauugagcccaggaacaacgaga
ccucuguuauccacucccuaccuunuggugaguugcuugcaggucaccguagggcaaaguucuungag
ugucaguuaaugcguuggaguuccuuugcuucguaauucugagcucanugaacaccagaaganucau
ganagagaaagaccuuucuggaagccgacanuaugagcgcucugucauccgcagccuugcgcccag
ugacccucagaccaguuaugcccaagaacguuucauccaagaacaagagcguaaauucagagcguu
uuggacaacgcucaacuaccagcaacaaccucaguguacagaaaaucuaugcccaagagacauuuu
aaugccgaggagccccauganaaagaaacucauauucaaaaaaunucaugacaaagagccauaugg
uaaggagcccaguggcaaggagcccauggugaugagccccaggacaaagancccuuguucaggagaug
cgcagugaagagccccaugaugauaagccccauggccaggaucccaugauuauaauccca
uggccaggaucccaugaugauaucccauagccaguaucccacggugaugagccccauggccaggag
ccccacggugaugagccccaugacaagganccauugaucaggagaugcgcagugaagagccccac
agugaagagucuucauggugaugaucccauggugaagagucccauggccaggagaaaguugaag
augcuuaccauuaggccucaguuucugaagagcaucagaaagaugacguuaggugaugaaucuaug
aaugccaggacugugggcugggcuuacuuuncuuaugaccucacaagccaccaggacacccauagcag
aaaggcucugguugacagucgugaauaugcacauuugaaguucaugcccacuccgucagcga
auuugagaaaaaaugcucuggagagaaacuauaugaauguccaaaauguggggagucuuucauua
cauucguuwauuugagcaccagagaguuucacgaacaagaccagcuguauuccguaauugccuguuu
augacgcuuucaucuucuuugcccguuagaccaaggauaaauugcnuguugaaaggaauccugccguu
ucuuagucagccauucgaugccgucaguguggauaggcuucauucacaguucugcccuaaaugag
cacaugagacagcacagagauaaugaaauaauggaacagaguugcuuwagaugagauuucauuca
aggccuauccucacugaguaucaugggauugaanagaagagaaguuuucgagugcacaaucuguag
ggaaugcuuuucacugccaaacagaucggggaccaccacaccaaagucacaaagauuuauccuaugag
uaugggcccuccuacacccaugccuccuuucucaccgaucccucaggaagcacaucccacuguacg
aaugcaaagauuuggccaguccuuuccuagacgacacugucauucgcuugcgcaugguguuucaucc
ugagcgagaaggugugucagaaauauagcugccacugcccaaaaggucgaagccaauguccuca
ucccacaagaaguacugcgaauccauaggucaaaugcagaagcugcugagcccgaaguggaggcu
uagagcccgagguggaggcugcagagccugagguggaggcugcagagccuauuggagaggcugaagg
gccagauggagaauuugcugagccugauggcgaggcugagcagccaauggagaguuugaacagcc
aaacgaugauacugacgagccauacagagccguaaucgaagacccagaagagaaagaugacgaaccug
agaaaangucgaagagccagagggagaugcagaugagcccgauggugcagacauugaagacccaga
agaggaaggagaagaucaagagauugagguugaagaaccauacuacanugucaugaaugcgcagaan
guugcuuccagcuagccuuuggcgagcaucugaaaagucacgccagugugaucaucuucgaucuug
ccaauccuggagagugcucuuggcuacauugangggccauaccagugcagguggugcggagcaguag
acgacaaguacuucaaaugugaugugugcgguaacucuuangaccgccucucccuugccagacac
cagaauucucacacugguugaguaaccaggcugaagaaaagaagaguaagccaaaccuucuucccag
aaccagaccuuaauaaaucacaaagagagccuauuaccanccauaaugucuuuaagaaauua
ccuuccuguauacauaccggacuucacaucaaagacuuucacucucaucacaanugaaaaaag
aaaagacauuuaacgcagggacucuuuwaguuuuaucuguucccuauggaacaucaguguauauu
ugggaaagcuagagugaacaucuacaucuuccauuucaucuaaguaacuagauugagggaaaccu
agugauauuccagaccacagagguuucccagucgacuguauuaugauaccccuuuauacccunac
auaaugauuccugccauguauauaaaugagcaaaucagugauacauuuuuuuaauuuaguguacu
auauaauuunaguuunucuuacagagcuaccuagccugguacucuugauuuuuucccugaggag
gaagagagcaacaauuuagcauauauuuguaaguauuguccaugcagaagcuuuucuuuagcauca
uuugancccauuaguauuccuuucaguaauguguguucuguccccuaccucuuuagauaguccug
ugaagauguggguaugaaauaucgugugucuuuuuaauccuggcuauguggaaacaggcauuuuagc
uuunagccauuuggugugcacccagaccccuugagacugauuguguaacccuuuacaauauauggau
uugucucugugacccaaaucaacccaucccuacauuuauauaccuunagugguuuuuugc
Growth Factors, Receptors and Related genes
Fz2/ 9 uuuuuuuuuuuuuuuuuaccguucuuuauuuaaaaaaauaaaauagga 238
Frizzled 2 (17) guccguagggugcacccuccccccuccugagugaaggagggcnggugc
AW123618 aguccggaccugggagaggggaaagcccguaggcaggcgagaccgcuu
cacacaguggucuuccaugccggcuguuguugaucgaguguaganu
uccuccacgagugcagugucuugccggaccagauccagaauccangu
gaugcccacgaugaugucaugagguauuugaucauguagacugugaa
gucgggcguugcggggcguguagugguauguaggggauggcuag
gcucaugcagugauguuucccaggauacucccagugcucgcgGaaG
gccugcucauagaaguagcaggcgaug
Dkk3/ 6 Sequence below. 239
Dickkopf 3 (22) ggccgcuuucgacgccucuccauucugcucuuuuggcagcccagcuaccggucgugaccagauccagc
AJ243964 uugcagcucagcuuuguucauucgaauuuaugcggcggccagcgcggaacaaacaugcagcggcucgg
gauuauuuucuguguacacuugcuggcggcggcgguccccacugcuccuuucuccuuccccgacggu
cacuuggacuccggcggagccgqucccagcucuucaacuacccucaggaggaagcuacgcucaa
ugagauguuucgagagguggaggauucugauggaagacacucagcacaaacugcgcagugccguu
uaggagauauaggcggaagaagcagcugcuaaaacguccucuguagugaaccuggcaagcuuaccu
cccaacuaucacaaugaucccagcacggagaccagggugggaaauaacacaguccaugugcacca
uaaguucacaagauaaccaacaaccagaguggacagguggucuuuuucugagacagucauuac
aucuguaggggaugaagaaggcaagaggagccaugaauguaucauugaugaagacuguugauccc
accagguacugccaguucuccagcuuucauuacaccugccagccaugccaggaccagcagaua
caugggaccaucugugacaaccagagggauugccagccuggccuguguugugccuuccaaagaggc
cugcuguuccccgugugcacaccccuugcccguggagggaaagcucuaccaugaccccaccaacc
agcugcuagaucucaucaccugggaacuggagccugaaggagcuuuggaccgaugccccugcg
ccaguggccuccuaugccagccacacagccacagucugguguacaugugcaagccagccuucg
ugguucagccaugaccacagugaggagagccagcugcccagggaggccccggaugaguacgaaga
uguuggcuucauaggggaaguuucgccaggagcuggaagaccuggagcguuagccuagcccaggauu
auggcauuugaggggccugccccuguggagucacuaggcggagaggaggagauuuaggcccagacc
cagcugagucacugguagaugugcaauagaaauggcuaauuuuauuuuucccaggaguguccccaug
uguggaauggccgcagcuccuucccaguagcuuuuccucuggcuugacaagguacagugcaguacau
uucuuccagccgcccugcuucucuggcuugggaaagacaggcauuugcgguuuaagggcagcggug
agucgucccucgcuguuacuagaaacgcugucuuauucuucauggauggaagauuuguuguaggga
guggaugggaaggquugaagucuugcucaugauggauuuugggauacagggaggaggaugccugcc
uugcagacguggacuuggcaaaauguaaccuuugcuuuugucuuguccgcucccauguugcugag
gcaguggcuacacaagagcuaugcugcucugugucucccacauauuucaucccuguuguuuca
gcuccuaccucacugucagcacagcccuucauagccacgcccccucuuugcucaccacagccuag
gagguaccagagguacuucucucagagccccaugcucucucucucaaccccauaccagccucugug
ccagcgacagcccuuccaaauguuagguuagugaaauccuuuguuuuuuauuauuuucuccuuca
uaggcacgccugccacuaaggucaguucuaacuugcauugucccucuaacguucguaacaaugug
guagacacugcuuccaccgacugcuucaauaccucugaaagccagugcucggagugcaguucgug
uaaauuaauuugcaggaaguauacuuggcuaauuguagggcuaguouugugaaugaaauugcaaag
ucgcuuagcaacaauggaaagccuuucucagucacaccgagaagucacaaccaagccagguugugua
gaguacagcugugacauacagacagaagaaguucugguucuggaugucagucucagaugacgguuu
cagguuuccaggaacuauuaccauucuguaucuauccagaguuauuaaaauugaaaguugcacaca
uuuguauaagcaugccuuucuccugaguuuuaaauuauauguauacacaaacauguggcccu
caaagaucaugcacaaaccacuacucuuugcuaauucuuuggacuuuucucuuugauuuucaaua
aauacaaauccccuucauuucaaaaaaaaaaaaaaa
Sfrp1 6 Sequence below. 240
Secreted gcacgagcagcccgcagcccgccgcgccuugugcgagccgggacaacacuucggccccgcgcgcuccc
frizzled- cgccgcggcgaccugcugcagcggaggaccccaucgaucggagacccggggagcagcgcgcagcccgc
related ccgacugcgucuuuguccccggaggcuccgggaaguuugcagcgggacgcgcgcgugaaggcagcgu
protein II ggggagcaccccacgccagcccccgacgggcccaucccgacgucgccgaacaacaugggcgucggg
U88566 cgcagcgcgcagggucgcggcggggccgccucgggagugcugcuggcauuggccgccgcucugcug
gccgcggguucggccagcgaguacgacuacgugagcuuccaguccgacaucggcucguaucag
agcgggcgcuucuacaccaagcccccgcagugcguggacaucccgguggaccugaggcugugcca
caacgugggcuacaagaagauggugcugcccuuccuuuggagcucugaccauggcaugguuagca
gcaggccagcagcugggugccgcuuucaucaagaacugccacaugggcacccaggucuuccucugu
ucgcucuucgcgcccgucugucuggaccggcccaucuacccgugucgcuggcucugcgaggccgug
cgcgacucgugcgagccggucaugcaguucuucggcuucuacuggcccgagaugcucaaaugugaca
aguuccccgagggcgacgucugcaucucaugaccccgcccaauaccaugaugccucuaagcccca
agguacuucuuguguccuccaugcaacaacgaauugaagucagaggccaucauugaacaucucug
ugcaagcaaguuugcacugaggaugaaaaucaaagaagugaagaaggaaaacggugacaagaagau
uguccccaagaagaagaaacccuugaagcuggggcccaucaagaagaaggaguuagaaggcgcuuu
ugcuuuuuccugaagaacuugugccgacugucccugccaccagcuggacaaccucagccacaacuu
ucucaucauaggccgcaagaugaagaaccaguaccugcuaacagccauucacaaguaggacaagaaa
aacaaagaguucaaaaacuucaugaagagaaugaaaaaccacgagugucccaccuuccagucuguu
uuuaagugauacuggggcggacugggauuugggauuuguggcuuggggugaggguggguugcgcgugg
augacccuggcucuuuggggcucacauauugcucucucccauacaguguggcuuuugcauugcac
cugacucuguuccuacagcgaacccucucccuuuccuccauagccacauccagcuaaggccacggc
cuuuagauuaggaaggcuuuuuuuuuuuuaagggcugcagcagggccagcagcgacgugcaaa
aggagaggcagaauccuuucacugagccuggggcacaaaaaacagaaaauguuuuccgguuugga
aaaacaaaacaaaacggauuauaaagaacugcagacggacagcugcucagcucaacguuguucggg
acaucauuaccaauugcuuuuggagucuaagccucuacagguagaagagucugaucauugccaagcc
aggcugcuuucaguuuauuauuaaucccccucuuucugccuuagauagaccaucgccaccuucaaa
acacacacacacacacacacacacacacacacacacacacacacacacacacacacuucugaaagua
gccagguuaucccaguauauucgggauagcuaaggguuugggugggaggccauagcuacucuaccuc
agcuuuugaacuggccaccuuugauaggaaacugaggucucagauggacacuucuaccaguccaucg
ggauacaaggaugccaggcaagggucuugcuuuugucugaaggagguacgugggcaugaagagac
augaggcauuucaggcugagaagcaacagcuacuaguuuucaucaauagaguuugaugaaaugag
caaagguagaaauuuucaagcaggucacaagucugggugauuuuggggaauccugugccaacagc
cucacuuuguaauuccaucuugucacuuucaaaagaucagcaacauaaaacagggauaaaagccc
acauucccuccaaggcuugaguaaaaguccacacucagcauuuaaagacuaacgucguugacugcc
caaggcugcccucuuaauacaccgccuaugcaugugcuguguauugcaacucugugcaugug
cuguggaggagaugggccucauggcugugcuggcagcccguuucaguauagcguggaaagaga
caguauccauagacucugcuuuucugcaaggaaagcccuuuuccuuauacaugauugccuauaa
uucagacaaauuuaaaaucgcugccugccugagcccuccaccuuuacuuuugcauucuuccgguca
uauucuuuugaggcuauagugcccuauccuggagaugguuucauaggcuaacuauucugcagcu
uucccaugugcccagagguauuucucaaaguugguaugcuuaauaagugauguaaauuuccagu
ucuucuuaggcaaccuuacuccuguugucccug
Dab2/ 15 Sequence below. 241
Disabled aauuccgaguggccgcgcggcuauuuaaguggcguuacuccgcguccucggcgcagccuugaggcuucggg
homolog 2 cgcgggggaagucaugauugcuccacagaugcacuagcuaguccguuuuacuuuguggguuuaguccuuuuu
U18869 gaccgcccgccggagauuggcuaguaucagugacugucuacugcuggauuuucuacuugccuucccguc
augucuaacgaaguuaaaacaagcacaaccaauggccagccugaccaacaggcugccccgaaagcgc
caucaaagaaggagaagaagaaagguucuugaaaagacagacgaguacuuguuggccagguucaauggug
augguguuaaaucaaggccaagcuaaucguuuauugaugaugugccuuuacucgagaagacaaaaugagu
ucaggauucuaugaugaaacucaagagaauggcagcagcuggucgcucuucagggacaacacaagcaaag
aaucugggucaacauuuccuugucuggcauaaaaaucauugaugagaaaacugggguaauugaacaugaa
cauccaguaaauagauuuccuucauugcucgugaugugacagacaacagagcauuugguuaugugugugg
aggugaaggccagcaucaauuuuuuacuauaaaaacagggcaacaggcugagccauuaaucgucgauc
uuaaagaccuuuuuucaaauuaucuuaacccuugauugucaagcuaacaaauugaagcuggguguugac
cagauggauuuguuuggggacaugucuacaccuccugaccuaaauaguccaacagaaagcaaagauau
ccuguuaguguuaucuaaacucugaaaucuuacaccaaucagaacucuuuaagagaaaauccauuucu
uaacaaauggagucaccuccuguuucucucccucgaccaaagccucaggcauccuucuugccugagaacgc
cuuuucugccaaucucaacuucuuucccaccccuaacccugauccuuuccgugaugaucccuuugcaca
gccagaccaaucggcacccucuucguucgauucucucacaucuccagaucagaagaaagcgauuucugag
uagcucgucuacuccacagaguaaagggccccugaacgucgauacuaauuuacuuugguucagcaau
uugaccagcucuucuaaccggacuuggcaaaccggaagcuucagggaggcccguggcccuacccaag
uucgcagacccagcaagcagugagaacucaaaaugggguaucugaaagagaacagaacggcuuccauauc
aaaucuuccccgaacccuuuugugguuaauucccucccaaaggacuaucgguaccgaauguucguaaag
cagaacuuggaaaauucuauccaguccucaacacaugacuccauagccauuauucccaccuccacaa
aguaccaaaccaggaagaagcagaaggacugcuuaaguuucuucagcaaacgacuugccugcuucagaca
ucuuuugccucagaaccuccaggccagauugucccccacauugacaaccugcagucccgcagucgaa
cuuccuggaucucuucaaaggcaaugcuccucccccaguggggccccuuguaggucuuagguacgguccca
guaacacccccccaaacaggacccuggacgccuguugucuacaguccuucgacaacuaugguccca
ggagccauuaauaaguggccagccucccaguuuucgccagccacucguuuuuugguacaaccccagcaguu
uacaagucuggaaucagucuccaucauuugcaaccccagcuuccccuccaccccccacaguuuguguccua
ccacaucuguggcgcccaacgcuuggucauccacaagcccucuauggaauccuuuucagaguaauaauau
cuuuccaccucccaccauguccacucaguuccucuccucagccuuuaugauguccucuguucuggcca
caccgccucaaccaccuccccgaaauggcccacuaaaggacauucccaggacgcuuucacuggcuuagac
ccccuuggggauaaagaggucaaggaagugaaagaaauguuuaaggacuuccagcugcggcagccaccuc
uuguuucccucaaggaagguuggagacgccucccucugggacuucaagcgccuucuccaguuacuuc
aacaauaaaguuggcauuccucaggagcauguagaccaugaugauuuugaugccaaucaacuguugaa
caagauuaaugaaccaccaaagccagccccgagacaagguguccucuuggguaccaagucugcugac
aauucacucgagaacccuuucuccaaaggguucagcucaucaaaccccucuguguuuuuucucagccug
caucuucugauccccacaguuagcccuuuaugaaauccuuuugccuuagcuucuugaaguuguaauga
ugacuauccagaugagcaaaagacuggcuuuggucaagaaugaagcagacagccagaaacauguuga
ccucuguccucgcuccagcuuugacguauuaucuguuacccuauuuguuuuggccucuuguacuuguaa
aaugccuuucauuuuccuuucuaggcuaaagcuaaacuuaaacuaugucuuuuguaaauuuuucuccua
aacucucuagcuccaauauuaaaugaaguagcuucccuaucaaaucccugucuguugugcccccuuga
aacuuccagaauuauucuccauuucuacccuccauuugggaggagcggcuaccuuuacccuuaauau
cacacugccuugagucaauguccaaauacucauagcucucaaagucauuuggguuuuccuggugugc
ggccuaaaccuaaagcauccuuuaauagggaaguaagacaccuugcuuccuauguccacuucaggga
gaauuuuuauuuaauaaaauaaaagcaaaacuaacuucucaaauccacccaaggaccauuuuugagau
gguucguuucucagcuaacugcaccauuuuaccaauccugccccaaguggugcuuacauuugacuuuga
agaagagaaagagcuaacuuucaaaacacaaggcauuauuucaaagcuaauaaaacaauuucucccug
gggccccacauuguuuucauuccagauacguugcagcuguuugacccuaaugacauuaugcccuaca
uuuuuuccuuaaaaauccugauuuuuauuuucaugugauuuuuguuucuucaauaaagaugauuauugug
uuugcacggaauuuc
Cktsf1b1/ 12 augaaucgcaccgcauacacuguaggagcguugcuucuccuccugggg 242
Gremlin, (12) acccuacugccaacagcugaggggaaaaagaaagguucccaaggagccau
Cysteine uccgccuccugacaaggcucagcacaaugacucugagcagacccaguccc
knot caccacaaccuggcuccaggacccgggggcggggccaggggcggggcac
superfamily cgccaugccuggagaggaggugcuugaguuccagccaagaggcccugcac
1, BMP gugacagagcgcaaguaucugaagcgagauuggugcaaaacucagcccc
antagonist ugaaacagaccauccacgaggagggcugcaacagccgcacuaucaucaac
1 cgcuucuguuauggccagugcaacuccuucuacauccccaggcacaucc
AF045801 gaaaggaggaaggguccuuucagucuugcuccuucugcaagcccaagaa
guucaccaccaugauggucacacucaacuguccugagcuacagccaccca
ccaagaagaaaagggucacacgcgugaagcagugccguugcauauccau
cgacuuggauuaa
Fgfr1/ 10 Sequence below. 243
Fibroblast auggaauuauccauggagguacauagccuuuguuaccaaccuuuuaaccgcagaacugggauguauggcua
growth gaagugccuccucuucuuugggcuugugcuuuggucacagccacucuuucugcacugccaggccagccccaa
factor accuugcccgaacaagcucagcccugggggucccuguggaaguggagucucuccugguccacccuggcgac
receptor 1 cugcuacagcuucgcugucggcuucgcgaugaugugcagagcaucaacuggcugcgggauggggugcagc
U22324 ugguggagagcaaccguacccgcaucacaggggaggagguggaggugcgggacuccauccccgcugacu
gcuggccucuacgcuugcgugaccagcagccccucuggcagcgauaccaccuacuucuccucaaugucuca
gaugcacucccauccucggaagaugaugacgacgacgaugacuccuccucggaggagaaagagacggaca
acaccaaaccaaaccguaggccuguagcucccuacuggacauccccagagaaaauggagaagaaacugc
augcggugcccgcugccaagacggugaaguucaagugcccgucgaguaugacacccaaccccacucuugcg
cuauugaaaaauggcaaagagugacaagggcaacuuacaccuuucaucguggagaaugaguaugggagca
ucaaccacaccuaccagcuugacuuucguggaacgaucuccgcaccgacccauccuuucaaucagggcu
gccugccaacgagacaguggcccuaggcagcaauguggaguuucauguguaagguguacagcgauccgcag
ccucacauuucaguggcuugaagcacaucgaggugaacgggaguaagauucgggccagacaacuugccg
uauguccagauccugaagacugcuggaguuaauuaccaccgacaaggaaauggaggugcuucaucuacgga
augucuccuuuugaggaugcgggggaguauacgugcuuggcagguuacucuaucggacucucccaucacu
cuugcaugguuugaccguucuggaagcccuggaagagagaccagcuugugauugaccucaccgcucuacc
uggagaucauuuaucuacugcaccggggccuuuccugaucuccugcauguugggcucugucaucaucuau
aagaugaagagcggcaccaagaagagcgacuuccauagccagauggcugugcacaagcuauccaaga
gcaucccucuggcagacagguaacagugucagcugacuccagugcauccaugaacucugggguuucuccug
guucggcccucacggcucuccuccagcgggacccccaugccggcuggagucuccgaauuaugagcuucccu
gaggauccccgcugggagcugccacgagacagacuggucuuaggcaaaccacuuggcgagggcugcuucgg
gcaggugguguuggcugaggccaucgggcuggauaaggacaaacccaaccgugugaccaaaguggccgugaa
cgauguugaaguccgacgaacggagaaggaccugucggaucuugaucucggagauggagaugaugaaaaug
uauugggaagcacaagaauauucauucaaccucugggagcgugcacacaggaugguccucuuuaugucauu
cguggaguacgccuccaaaggcaaccuccgggaguaucuaaggcccggaggccuccugggcuggaguacuu
gcuauuaaccccagccacaaccccgaggaacagcugucuuccaaagaucugguauccuaugccuaucaggu
ggcucgaugcauggaguauucuugccucuaagaaguguauacaccgagaccuggcugcuaggaacguccu
ggugaccgaggauaacguaaugaagaucgcagacuuuggcuuagcucgagacauucaucauaucgacuacua
caagaaaaccaccaacggccggcugccugugaaguggauggccccugaggcguuguuugaccggaucuaca
cacaccagagcaauguauggucuuuuggagugcucuugugggagaucuucacucuggguuggcuccccaua
ccccgguuguaccuguggaggaacuuuuucaagcugcugaaggagggucaucgaauggacaagcccagua
acuguaccaaugagcuguacaugaugaugcgggacugcuggcaugcagugcccucucagagaccuacguuc
aagcaguugguggaagaccuggaccgcauuuguggccuugaccuccagccaggaguaucuguuaccugucc
auaccgcuggaccaguacucacccagcuuucccgacacacggagcuccaccuuucuccucaggggaggac
ucugucuuuucucucaugagccguuaccugaggagcccugucugccucgacaccccacccagcuuugccaa
caguggacucaaacggcgcuga
Fgf1/ 10 auaucugaaauggagauucacaaccuucgcagcccugaccgagaagunca 244
Fibroblast accugccucuaggaaacuacaaaaagcccaaacugcucuacugcagcaac
growth gggggccacuucuugaggauccuuccugauggcaccguggaugggaca
factor 1 agaucaggagcgaccagcacauucagcugcagcuucagugcggaaagug
M30641 cgggcgaaguguauauaaaggguacggagaccggccaguacuuggccau
ggacaccgaagggcuuuuauacggcucgcagacaccaaaugaggaaugu
cuuuuuccuggaaaggcuggaagaaaaccauuauaacacuuacaccuccaa
gaagcaugcggagaagaacugguuuugugggccucaagaagaacgggagc
uguaagcgcgguccucggacucacuauggccagaaagccaucuuguuuc
ugccccucccuugucuucugacuag
Gpr49/ 64 Sequence below. 245
G protein- (377) auggacaccuccugcguccacaugcuccuguccuugcuggcgcugcugcaguugguggccgccggcagcuca
coupled ccgggaccagaugcgauaccgcggggcugcccaucacacugucacugugagcuggauggcaggaugcugcuc
receptor 49 aggguggacugcucggaccugguugcucucuugagcugcccuccaaccucaugucuucaccuccuaccu
FEX ggaccucaguaugaacaacaucagucagcuacccgccagucuccuacaucgccucugcuuccuagaagag
AF110818 uuacgucuugcuggaaaugcuuugacacacauucccaagggagcguucacgggccuucacagccucaaag
ugcuuaugcugcagaacaaccagcugagaaagguuccggaggaagcgcuacagaanuungaagccuucaa
ucccuuucgccuagaugccaaccacaucagcuacuuugccacccagcuguuucagcggccugcacucccug
aggcaccuguggcuuaaaugacaaugcuucucacagacgucccuauccaggcunucagaagunuaucagccc
ugcaaaccaugaccuuggcccugaacaaaauacaccacauagcagacuacgccuuuggaaaccucuccagc
cucgugguucugcaucuccauaanaanagaauccacucccugggaaagaaaugcuuuuuauggacucca
cagccuggagacuunagauunaaanuauaanaaccuugauaaauuccccacugcaaucaagacacucucca
accunaaagaacuagganuccacagcaacaacaucaggucaauaccggagcgagcguucguaggcaacccu
ucucuuaucacaauacacuucuaugacaaccccauccaauuuguuuggaguaucugcuuuucagcauuu
gccugaacuaagaacacugacuuuugaauggugccucgcacauuacugaauuuccucacuugacaagaac
ugccacccuauagagucugacuunaacuggagcaaagaucucaucucuuccccaaucccuucuaugaucag
uuaccuaaucuccaagugcuagauuugucuuacaaccuacucgaagacuuacccaguuugucaggcugc
caaaaacuucagaaaauugaccugaggcauaacgagaucuaugaaauuaagggcagcacuuuucagcaguu
guuuaaccuccgaucucugaacuuagcauggaauaaaaungcuaucauucaccccaauacguunucuacg
uugccgncucuaauaaagunggaccuaucauccaaucuuccugucguccuucccugugacuggguuacau
ugguuuaacucacuuaaaauuaacagggaaccgagccuuacagagccugauaccaucugcaaacuuccca
gagcucaagauuauagaaaugccaucugcuuaccaguguugugcauuuggggggugugagaaugucuana
aaanuucuaaccaauggaauaaagacgacggcaacauuuguggacgaccuucauaagaaagacgcuggg
uuauucaaguucaagaugagcgggaccuugaagauuuccuacuugacuuugaggaagaccugaaugcc
cuucacucggugcagugcucgccuuccccaggucccuucaagcccuguuagcaccuauuugguagcua
gcugauccgaaucgggguauggaccacggcaguacugacgcuuuccugcaaugccuugguggcuuugaccg
uguucagaacuccccuguacaucucuuccauaaagcugcuaauugggguaaucgcgguaguggacauucuc
augggggucuccagugcugugcuggcugccguggaugcauucacuuuuuugccguunugcucagcacuu
gugcguggugggaagacggaaucuugcugccaaaucguuggcuuccuguccauuuuungcuuccgaaucgu
cgaucuuccugcucacucuggcagcgcuggaacgagguuuuucugucaagugcucuucgaaguuugaagu
gaaagcuccccuuuuuagccugagagcgaucguuuugcuauguguccuguuggcccugaccauugccacaau
ccccuugcuaggauugcaguaaguacaaugccucuccccucugccugcccuugcccuuuuugggauccauu
caccacgggcuacaugguggcuucucguauncucaacucucucuauuuccucauuaauugaccauuaccua
cacaaagcucuacugcaguuuggagaaauagagcuggagaaucuuugggauuguucgauggugaagcacau
ugcucuguugcucuucgccaacugcauccuuuacugccccguuugcuuucuuauccuucuccucuuugcua
aaccucaccuuuuaucaguccugacgucauuaaauuuauacuucucguuuaucgucccacuuccuuccugu
cucaacccacuucucuuacauuguucuucaauccccauuuuuaaggaggauauaugcagccugggaaag
cauacccguuucuggaugagaucaaaacacgcgagucugcuguccauuaacucggacgauguugagaaacg
guccugugagucaacccaagccuuuaguauccuuuacccacgccagcauagccuauncuugccuuccacuu
ccgguugcaucaccagcuuaccccaugacugaaagcugucaucucucuucaguugcauuuugucccauauc
ucuagugacuauaagagaggaacguuuuuaagaguuggaaaccugaaaagugauuucuaucagagcagua
gcuaagaaaagcugagcuaaaaaccuaccuuaaaacccaagcaaacaucucuaaauugguguggaaacagu
ggugccuuagagcaggagagcaucauuaaacaccgcuuguaucauuuguucaacuaagaauaaagccauca
aguucacuuagaugaacccagaugagaaaagcagccugaaaugcucuuucgcauuuguaguucucuucuga
cucaccagcauagucucccauagugagaagacucguuggaugacucaauggguguauuuuaaauccacaaa
uuccuuguuuaaaagguuagaguuuuaagaaaaaaaaaaaaaaaaa
Igfbp5/ 37 Sequence below. 246
insulin- uuuuuuuuucuucaccuccucccuuuucaaggccuccaaacuaauuauuuucuguuugcuuuauagugagc
like aauucugugguuucucuccaccaccacccccaauucugacccgaucccgccuggggguuucuacggucuc
growth cgcucacucugcgugcaccuggcgcgccucuuuuuuucacccccaaccuguugcaagucuuuaauccucgca
thctor auugggacuugcgugcaggcaccugaauccuccuuugccucauauuuuugcaaguguuugggauagagcac
binding cugcucuaccugcaagagauuuaaaggaaaaaaaucuccaaucucccucuuucuccacacacucucgcucu
protein 5 ccugccccgccccgagguaaagccagacuccgagaaaauggugaucagcgugguccuccugcugcuggccg
L12447 ccuaugccguaccggcucaaggccuggguucuuucgugcauugugaacccugcgacgagaaagcucuguc
cauguguccccccauccucugggcugugagcuggucaaagagcccggcuguggcugcugcaugacuugc
gcccuggcggagggacagucguguggugucuacacagagcgcugcgcccaggguuugcgcugccuccccc
ggcaggaugaggagaagccgcugcacgcccugcugcacggccgcgggguuugccucaacgaaaagagcuac
cuucgcauuuuccgagcugaagggcugaggcugugaagaaggaccgcagaaaaaaacugacccagucca
aguuggcgagcaaaccaagauagagagagacucucgggaacacgaggaacccaccaccuccgagauuugc
ugaagagaccuacucccccaaggucuuuccggcccaauucacauuguggggggugcagagaacacugccc
accccagagucaucccugcaccugagaugagacaggaauccgaacaaggccccugccgcagacacauguau
aucuucccuccaggaguucaaagccagcccacgcauuugugccccgugcuguguaccugcccaacugugac
cgcaaagaauucuacaagaaaaagcaguguaagcccucccguggccgcaaacauggcauucugcuagugu
uguagacaaguacggaauugagcugccgggcauggaguacguggauggggacuuucagugccacgccuucg
acauucauuuaacguugagugacgcguccccucccuuccucccccuauccuacccccccagccccaacuc
cagccagcgccucccuccaccccaggacgucacucauuucaucucauuuuaggggaaauauauuauaca
uauauauuugaggaaacugaggaccucggaaucucuagcaagggcuaaagagacacuccccaccaugaccc
cggaaauguauuccuuuuuugaagcaaguugaacggacagagaagggaaggagagaagaagcaagaggga
gcgagagauggaaagaaagcaaagcpuggaauagaggaaaagagggaaggacagauaggauuagagagag
aagagagaaacagcaaggcagaaaggacuccacaaccaaggcugaaucugcccuuuuucuuucagcucua
gccuggugucagaaaaauuugcuccugcagccagcaguguggauggcuagaccccucacccucccuccuc
cuuacccaagugcagugugauucauccccaaauuacaaagacuaaaauuucauuccaucccucuuuaaaau
aaacaaaagugaguuuauugaagauagguuauucccccagcagacaaaugaacucagaauauguugca
aauuuuacucuuguuaaagauuuuuuuuaagaagucaguacgcacccccaacacuggaaagacuugauucu
ccagggugacaagcaauucagaagcgcguggcuucggcccuugauuucacuagacucaaagcuggcccgga
gccucuguggaggaggaugagagguggagaaaaccaaggggcuuguacucacccacaauuacuccauguag
acuuuauagacauauaaaucuauuuucuuuuaccuuuuuuucccuuucccuuucuuucgaaguuuuacauu
accucuuuaaaguaguuuuuuuuuuaggacacuuugaagaucuuccucauuucugggaaaaauccauauu
ucacaaauacaacccagaacgccagcuuuggccugcguccaggcagccuuucucgugauucuacaagugug
gcucuuuuuuuggggcaccgauuugaucuucucaugauuccaaacguguguugaaaugaauccaccaagcc
aggaacugccagcacccaaaggugcaucaagugcauuaacccaagucaccccauuucagccuucca
acccgcagaaaguaacugucucacaccacaccacauuaaaccugccagauccaucuguaacccacuggccu
gcccagaccuuuuuuucccaucugcauuuuuuuuuuugaacugcauuuugaaagccucccucagaugccag
gcugacagaucaaagagaaacuaacaugaaagaugacagaggaggaauaaguggaggguugauggcaga
gacuuccacagagagacauagaaaauggagcagaggucuggggguggggaggacaagaaagagacagagag
caggaaaauuaccaauagaauuuuuccuuggugucuuuccaucuaaucaacucucugagauuugagaggaa
aaagaaggcaggggaagaacuugagguagaaaugaggucaguucaagucacagggcccagauuugugggua
acugaggcaggauccagacuuuagacacacgguuugaaacaaggcugguuauuccugacuggguauuugaa
gggugaagaggaugccuuggaaagacagcacaacuucaguuuucaacuucaggcccccaaggaggaacu
gaggccaaagaauccuuucaagugcuucauuggucuccucugcccgacucaaacauccuucccugugaugg
aggaugguagaaagcccaggacaacucaggcccguuaucuucacgacuguugucauuugccagccugauu
auuuauccaagagaagcaucucauugcccacuggcuucuuucaacaaaaaggugcuuaacaaaaggcuc
aagacuaucuuuugaagacugaagauaaccuuccaggagaggagacucgugcauugguacaggaggcccc
uuuuuggcgggggacacagcucuuugcuucucucuugauguucauggcauaguagaggcccccuccaa
cccggauauguuagcaacacaaaguugagagcaaagaaacugacgugcgucgacucauaguuacaugggug
gcugcaugcacagaaagauaugccuccuauugccuggacaggacaguuggcugggaaggaaagagaaaa
uugaucuucauuaagacaaagggccugaugggauggcaauagaaggacuuaccagaccugcagggucagu
auacccaucaccccgcacaacauccccauucccccaacucaaacuucaauauaucuuaggccaguauccua
gaccuaagucucuccuuucugccauuauuucuccgcaucuugagcagucaucugacuugagauuugccaa
guuggauacugggauaccacuugccccccaagaaaagacuugagccagaaacugccuuacuuucgcucccc
cucccgagccuggagcuaacuccugugaggggugcucucuucaccccacaacuuacuagaccuugagug
agccucugucccuuaugugggcucuucgcugugagccacagauggaggucauuuguauagacaguuagccu
uccccaagucagccuaccucccccaaacuugugaguucuccccgcugcuucauuauggaaaggcaucuaa
gacagcaagucuuucuagaggaagcuugccuuuuaacagacagauggaacuaaaccuuccaaaugggaga
ucuggcugaacccaggauuacagagaccauggacauggaugggpucaucaagagaagagggauguccuu
cuccagguuagggagagagaaggcaaguuugcaacgaucccaucaugcccugagcaagaagcuauuguuc
ccauugcuagccuuuaacuccauuagaggccucucuguuugguuuauccacagcaguaggcccaaguaug
gccuguuuccccaccucuacuuuaucccguggaagguuuucuucccaccccuuuuuugacaaaugccuca
cucgagcaguggaaagauagcucucuucccccucuuucugccagguaacaaagagaccuaaccaggacc
uauucuccaccccagccagucuuugaccagccagaacaaauucagggaaccuggagaauaaaagacucuac
uuuuccucuuuacaaagacucuuguuucucugacggccaauccuaaacagacaaggcuuguaacaucug
uccccacaggauacggaggagguucagcuguugcucacuccucuucuccuuccaagacccucuuccgacc
augacuuaucuccaugguuacauccucaccaucauucucccacuaccaaggguugccauggcaaccuccc
aaccaccugcccaucccaggcaggcagcuguccuucugcucauuaacccuauuaggacucuaguugaaauu
uuacagcuuuaagagaauagugagccaaggagaagagacccuauaguccucuuggcuuuucaagagaaga
aggcuaugauuuuaaaacacaguagaagggaaagaggucucgucgaggucgaccucucccggggagcuug
ggguuguacugucuuuauuuuuaaaccacuaaagugcaauuuuuccuacacucuuguuaccccgccucu
ucuuucccuguuuagguuuuuauuuccuugaacagacuuuuugguuuuuuaauggaguauagacuuuacc
acuucacagacucuggccuccucuccaagucucucuggauggggaaaaggaagguagaggpcagaggggaa
ggggucccucgucaccccgcauccauucacccccacuucucuggucccuagucaccuugcuucaccccuau
cuccgacaccaucacugucacacaguagccugucacacggauaguacaguuagacaagacuccuucagauu
ccgagacgccuaccgguuguuuuugguuuuuguuuuguuuucuuuuguuuguuuguuuguuuguuuuuuac
aacagcuuauaaccacaucacauauuacuguagcucucuauaguguuacguucagacaccpagcucugucc
uucucuuauuuuguugguuuuugacuuuaaaaaaaaauacuuaugcuuuuuuuacuguuugaaacagauu
gaaauaaaaauugaacaacaaaccaguugugaaaaaaaaaaaaaaugugaaaaaaaaucaccccgaugugg
aagagcuucggcuccucuuuagcauuuuguacuuuaaggaaauaaaaaagaaaaaccuggaagaucucac
auuuuauuacaaagugaaaaaaaaa
Myoc/ 111 Sequence below. 247
trabecular guccagucugcagucuguauucggaagacauagauacuaaauacauggcaacucuuuuuuuuguuuguuuua
meshwork auucaucaggauguggagcgcuagucuuggguaggagagccagucacccugaggacagcugaaacaaucgc
induced uggcaaguauggaguguggaugagagaccccaagcccacccaccccuuacacccaggaaagcacauggauu
gluco- gauuucauguuggcacagagaucuccagguguuugaauacagucagauaagccaauucgagcagggcuauc
corticoid cuuccaagguccaugugcucccucgggcacuuggaggcacgggugcugugguguaugcggggagccucuau
protein uuccagggggcugaguccagaacuguggucagguaugagcuagacacggagaccgugaaguagauuaagg
AF041335 aaauucuggagcuggcuaccacggacacuucccguacgcgugggguggcuuacacagacauugacuuacug
uagauugagcggccucuuaucaucuacagcacgaaggaagccaaggaggccauaguccucuccaaauugaa
cccagcgaaccuggaacuugagcguaccugggagacuaacauccguaagcagucuguggccaaugccuuu
guuaucuguggcaucuuguacacggugagcagcuuacuucuucauuccaugcaaccgucaacuucgccuuc
gacacuuaaaugggaccauuaagacccugaccaucccauucacgaaucgcuacaaguacagcaguaugauu
gacuacaacccccuagagaggaagcuguuugccugggacaacuucaacauggucaccuaugauaucaagcu
cuuggagaugugaggagccucuaugccuaccagcaaaggccagaaaaggugaaguucgucucccggguga
agcagcugucagcagaggcaucagaugcauggaguuuucuccuccugcuuagauuuuauuuuccaggucaa
uguacagcuacuccccucugacugacacguccuccaggcuuuguauagucgcauagacucuuguuucuucu
gucagcuuucaaagggcuguuccucuuuuaaaaaucacauagug
Itm2a/E25 30 Sequence below. 248
putative gggagaccugagcucgcugcugccuguggaagacugggagaggagacacuaagugcugcucaagcaagcgc
Integral gauccucuccucuuuucauccugcagcccaagauacugauucgagccguccuuaccgcuagaauuuuucac
membrane cauggugaagaucgccuucaacaccccuacggcggugcaaaaggagaaggcgcagcaagauauagaagc
protein 2A gcucaucagucgcacuguccgagcuucaaauccugacuggcaaggagcucagaguugucccgcaguuaga
L38971 aagaugucucaucugggagaugcaugcuuacucuccuaggccucucauucaucuuugccaggacugauugu
ugguagagccuacauuuacaaguacuuucaugcccaagaccaccauuhuaccauuggugagaugugcuucu
uugauucugaggauccugucaauuccauuccuggaggagagccauacuuucugccugugacugaggagucu
gauauccgugaggaugacaacauugccaucauugaugugccugugcccaguuucucugauagcgauccgg
cggcaauuuauucacgacuuugagaagggaaugacugcuuaccuggacuugcuuuugggaaacuguuaucu
gaugccccucaauacuuccauuguuaugacuccaaagaaucugguggaacuuuuuuggaaaacuggcaag
uggcaaguauuugccucauacuuaugugguucgugaagaccugguugcuguggaagaaauucgugauguu
aguaaccuugguauuuuauuuuaccaacuuugcaacaaccgaaaauccuuccgccuuuagacgcagagacc
uucugcuggguuucaacaagcgugccauugacaaaugcuggaagauuuagacacuuccccaaugaauuuau
cauugaaaccaagaucugucaggagugaaaugugacagauaaacaguauccuugauaauuaagaaguca
aggaacuuaccgucugacuuggaaaauuugaaauuugaugggauacucaugcuauuuacucauacauuua
cucuauugcuuauuacuggaaaaggaaagggaaaggggggagaaaacuacuuaaccacugcaagcgauug
uccaauuucuacuuuauugacauugcuuacuuguuuucaacaagucaaaugauuaucuuuuucuucuuga
auuuuauacgguuuuagauuucugaaagcagcaugaaugugucaucuuaccauccugacaauaaagcccau
ccucugguuuuauuuaaagcaagcucuuuccaacaucacuuggcuagagcaugcuuuaaauuuuaaaauau
auuugaaauuuuguuuugacauuuuuuugugugaaacaugucaaaucucuuaccauucuuuaguuuucuuu
cuuuauuaucuucaacucuccugauuucacauuuacauuuuugcauuucuuaucaggugcuguguaacgaa
ucugacugauaugugaacaaucuucaugaggaagcaauuuuuuuacucauguaaugauucuuucucacuga
uaauaaaguuuuaccguauucaauca
Eps8/ 15 Sequence below. 249
epidermal ggccauuaccaaucgcgacccgcgcacacacggcccgggcggcgggcgaagcgggcucccggggcgcugggc
growth gcagggcgcggcacaagccccaacaacgucucugcaacgcggcgcggcgggcacuccagcucccagaucuu
factor uucucccucggucaccucccucgcgucuaggaggucguggcacucccugaggagcgcggcugcucggagg
receptor gcggauccuagaacagaggcgugagagccggcaugaauggucauaugucuuaaccgcuccaguggguaugg
pathway agucuuacccuucucaacugaaugguuacggaucuuuucaccacccuauuucccagauggacagagaaca
substrate 8 cagcucaagaacaagugcaaaggcccuuuaugaacaaacgaagaacuaugccccagacagugucagcagug
L21671 ugucggacgugucccaguaccgcguggaacacuugaccaccuucgugcuggaucggaaagaugcaaugau
cacugucgaggacggaauaagaaagcugaaguugcugUuaugccaagguucaaaguguggacucaagauau
gauucuccaaguggaugaccgagcugugagccuugauuugacuuagagucaaagaaugaauuuggagaauuu
uccucuuaaacacaaucucgcauugucaagcaguggugcaugcaugcagcuaugacuccauucucgccuu
gguaugcaaagagccaacgcagagcaagccagaccuucaccuuuuccagugugaugagguuaaggcaaacc
uaauuuagugaagauaucgaaagugcaaucagugacaguaaaggugggaaacagaagaggcggccggaggc
ccugaggaugauugccaaagcagauccuggcaucccuccuccucccagagcuccuugccccuguaccacc
gggcacugucacacagguuggacguuaggaguucgcguagcagccugcucugccuaggcagcugaccagg
gugacuucgagaagccccggcaguaccacgagcaagaagagacgcccgagaugauggcagcccggaucga
caguugaugugcaaaucuuaaaccauuugguuuuggaugacauugaauuuuuuaucaccaaacuccaaaa
agccgccgaagcguuuucugacuuuucuaaaaggaagaaaaguaagaaaaguaaaacgaaaggaccuggag
aggacguuuuaacacuugagggcaaaacccccaccuccugacgaguuuguugacuguuuccagaaguuuu
aaacauggauucaaccuucuggccaaguugaagucccauauccagaacccgagugcuucagaucugguuca
uuuuuguuuacuccacuaaauauggugguccaggcaacagguggcccugaacuggccauaucaguacuc
agcccacuguugacaaaagacacaguugauuucuuaaacuacacagccacugcauaggaacggaagcugu
cggaugucacugggagauaguugggugaaagugagagcagaguggccgaaagaacaguucauucccacc
uuuacgucccgagguuccgcaacggcugggagcccccgaugcugaacuucaugggcgcgcccacagagca
agacauguaucaacuggccgaguccguggccaacgcagaacaccagcgcaauaggacagcaagaggcugu
ccacagagcauuccaauguuuuccgacuauccucagccgacggauaugcguacaguagcagcauguacca
cagaggaccacaugcagaccacggggaggcugccaugccuuucaagucaacuccuaaucaccaaguag
auaggaauuaugacgcagucaaaacacaacccaagaaauacgccaaauccaaguacgacuuuguguucga
ggaacagcaguagcucucgguuaugaaagaugaugucuuagagauacucgacuuaucgaaggcaguggua
gaaaguccauaaugccaguagagacucuuggguuugugccaaauaacauucuagauaucaugagaacucca
gaaucuagaguggggcgcgcugaccccccauacacacauaccauacagaaacaaaggacggaauuggccu
gagaucagcugacacuccuucugccccaucacccccuccauuuccagcaccuuuccggucccccuuccacc
auucuguaccagcacccuuucugugcccaaguuccagcagauugucacccgccagaacagcagcuccaaug
acaguaggggcagcauuaugcaugacagccagagauacaaacaacucccaguggaccgaaggaaguuucc
gcagauggaagagguucaggaugagcuuucuuccagaggcugaccaucgggcgcagucugaucagaggaag
uuccacgugccacggcagauguuccagugaucaauaucacuuaugacuccucaccggaagaaguaaaaacuu
cggcugcagucaaagggauucaaucccgugacuaucaauuagccucaugguuguuaaacggagcacaacu
cuuuucuucaacaaagacgaacugaggucugucugcccggaaggugccagagucuuuuaaccaaaucacu
uuguucagaaagcugcuuuggaggacaguaauggaagcuccgaguuacaagagaucaugcggagacggca
ggagaagaucagcgccgcugcgagcgacucgagaguggagucuuuugaugaagggagcagccacuaagucc
augaacuuccuuauucuuauuguuggucguugaacagugauggacaugcuuuguuuuaagaagccuugaa
ggggaaugucaaagcuugucguuucuugguauuauguaauuuuaucgccauauaaggaaacagauaugc
cugaguaagcagaggacccgcugcuucugugcacauuaguuugauuaaaacugagaagcggguagguagau
ggcucagcaaguaaaggugcuugcugccaagcccaaugacccauuuuucgagucccugggucuacauuu
guaguuagagagcuggcuuucugcaaguuguccucugaccaccacacauaaauaaauaacaaauguaauuu
auacaaacuuuuaaaagaaaauguaauuuaaaaaaccagacguucuagacugucugggcuugggaaauauuu
uuuucacuuuccuaagguguacuuuccuuugcuacauuaauuuugcagccuuguucgaugaucuaaguuu
gggauuuuuacaauggcagauuuauucauugcaacaaggaagacacagccauuugaugaaaaaaaaaaga
aagucuucagcuuucagugacuaugauaccugcuguccaaugaggaggcucaguuagacuacccucugcuu
acuuugaggucugacaugcccaaugagaguguauuuagcuuuauuuaaaguucuuaauuccaacaguuuu
aaaaaucacauuuaaaugauuguacaagguagccagaccuugaauguaugaauagacuauauuauaugucc
cgagaaacuuuguuacucuucagcucuguugauugcgaaaucuugcauagauuuuaugcuuugauuuaguu
ucu
Fyn/Fyn 10 Sequence below. 250
proto- ccugggccccgccgcagacgcgcggagccgccugggccgcgccggaggaaggcgaggagaggaccauguaa
oncogene augugcuccggagcugagcgccaagccaagcaguguuugaaaggaucaggaugcugaucuauucguggcaaa
M27266 uagucaguccgaccgcugguuucguagacaugugguguauauaaaguuugugauaguugguuugauauuugg
gagcuuggauaaugguucuguuuugcaauguaaggauaaagaagcagcgaaacugacaaaggagaggga
gcggcagccugaaccagagcucuggguaccacuauggcacaaccccaccccucagcacuaccccagcuu
cggcgugaccuccaucccgaacuacaucaacuuccacgcagcugggggccagggacucaccgucuuugg
ggguguuuaacuccuccucucacacugggacccuacgcacgagaguuagggacaggagugacacuguuu
guggcgcuuuauaacuaugaagcacggacggaagaugaccugaguuuucacaaaggaaaaauauuucaua
uauugaacagcucggaaggagauugguggpagcccgcuccuugacaaccggggaaacuuuuacauucccag
caauuacguggcuccaguugacuccauccaggcagaagagugguacuuuggaauacuuggccgcauagau
gcugagagacagcuccuguccuuuggaaacccaagagguaccuuucuuauccgcgagagccaaaccaccaa
aauugccuucucacuuuccauccguaauuaugaugauaugaaaggggaccacgucaaucauuauaaaaucc
gcaagcuugacaaugguggauacuauaucacaucgcgggcccaguuugauacacuucagcuacugguac
agcauuacucagagauagcugaugguuuguguuuuuacuuaacugugguuucaucaaguuguaccccaca
aacuucuggauuggcuauagaugcuugggauguugcacgugacucguuguuucuggauuaagaugcuggg
gcagggguguuucgcugauguguggcuugguaccuggaauggauauacaauaguagccauaaagacccuuu
agccaggcaccaugucuccggaguccuuccuggaggaggcgcagaucauguaguagcuguagcaugacaa
gcuggugcagcucuacgcggucgugucugaggagcccauuuacaucgucacggaguacaugagcauagga
uguuugcuugacuucuuuauagaugguuuaaggaagagcucugaaguuaccaaaccuuguagacaugcgg
cacagguugcuacaagaauggcuuacaucgaacgcaugaauuuuauccacagagaucugcgaucagcauu
cauucuaguggggaauggacuuauuugcuagauugcugacuuuggauuggcucgguugauuguagacaaug
auuacacagcaugacauggugcgauguuucccauuaaguggacagcccccgaugcggcccuguauggaag
guucacaaucaaaucugacauauauucuuuuggaaucuuacucacagagcuggucuccaaaggaagaau
gccauucccaggcaupacaaccgggaggugcuggagcagguggagagaggcuauaggaugcccugcccac
auacugcccgaucucccugcacgagcucaugauccacuuucuggaaauaggauccggaagagcgcccuu
accuucgaguacuugcagggcuuccuggaggacuacuuuacauccacagagccccaguaucagcccauu
gaaaaccugugagagccugcgcuucagacgccucuucccgaggccucccuaccccuccccauuugcuuc
caauucuguagccagcugccccagagcaggagaaccguccaggaucagauugcaugugacucuugaagcug
aucuuccacuugcccucauuuaugacacuugucccccaguccgaaccuccucugugaaccaucugagacag
aagcguguuauuucucaaacuuggaaaugcauuguaucgauguuaugucaaaggccaaaccucuauucag
uguauauagcugcuccugugccaucaaucccagugcuuuccuuuuuuuaaaaagaaauagcauauccu
augugauuuuuacucugauuucaccugauucaacuauauaaaaaauaguauuuuuuuccaauaguggcc
ucuuugucuaauacauuauauuuuuuuuucauguuuuaacaaaaaaaaaaaaaaaaaaaaaaaa
Structurally-related
Col6a1/ 36 Sequence below. 251
Procol- cccucccuggcucucuccucagcucugggcucugacugcagcaagcagagacaaccucucacucugccuuu
lagen, type cccagcgcccacccugacccuggcccacauuugacggugacucgcaggccagccagaaacaugaggcuggc
VI, alpha 1 ccacgcucugcugccccugcugcuacaagccuuucugguuuggccacacaggacauccagggcuccaaagc
X66405 gauugccuuccaauuacugcccuguggaucuauucuucguacucgacaccucggaaaguguggccungag
gcugaaaccuuauggggccuugguggacaagaugaagnccuucacuaagcgcuucauugacaaccugag
agacagguacuaccggugugaccgcaaccugguuuggaaugcgggugcgcugcacuacagugacgagg
uggagaucauccgagggcucacgaucaugcccaguggccgcgaugagcucaaggccagauuggaugcggu
caaguacuncaggaaagacaccuacaccgacugcgccauuaagaaagggcuggaggagcugcucauaggga
ggcucccaccugaaggagaacaaguacuuugaucguggugaccgacgggcauccucuagagggcuacaagg
aaccaugcgggggucuggaaaugcaguaaaugaggccaaacaccugggcaucaaguuucuuuucuguggcc
aucacaccugaccaccuguuagccacgucuaaguaucauugccacagaccacacauaccgacgcaauuuca
cagcagcugacuaggggcauagccgcaaugcagaagaggucaucagccagaccauugacaccauuguggac
augauuaaaaauuaacguggaacaaguguguuguucuuuugagugccaggcugccagaggaccuccagggc
cccgaggcgacccuggguaugagggggagcgaggaaauuccaggucuuccgggagagaagggagaagcugg
aagacccuggacgaccuggggaucuuagaccagucgaguaccaggguaugaagggagaaaaggggagccgu
ggagagaaggguuuccagaggaccgaaagguuacaagggcgagaaaggcaagcgcggaaucgacggggucga
cggcaugaaggggagacgggguacccaggacuaccugcugcaagggcuccccaggauuugauggcuuuc
aaggacccccgggucccaagggugaugcuggugccuuugggaugaagggagaaaagggugaagcuggag
cagacggugaggcugggagaccagggaacucagggcaccuggagaugagggugauccuggagagccugg
uccccccggagaaaaaggagaggccggugaugaaggaaaugcuggcccagacggugccccuggagaga
gggguggcccuggugaaagaggaccucgggggaccccuggugugagaggaccaaggguuagacccgggug
gaagcuggaccacagggugaccaaggaagagaggggcccgucggcaucccuguuagacucgggugaggcu
ggccccauuggaccuaaaggauaccgaggugaugaggguccuccagguccugagggccucagaggagcc
ccaggaccuguugguccuccuggagaccccggacugaugggugagagaggugaggauggaccaccaggaa
acggcacggaagguuuccccgcuuucccuggguauccaggcaacagaggcccuccugggcuaaauggcac
aaaaguucuacccuggccucaagggguuaugagagugaagugagagacccaggagaggauaacaacgac
auuucaccccguggggucaaaggggcaaaaggauaccgaagcccagaaggaccccagggaccucca
ggacaugugggaccaccugggccagaugagugugagauccuggauaucaucaugaaaaugugcucc
ugcugugagugcacauguguuacccauugacauccucuucguuucuggacagcucggagauucauuggcc
uacauuaacuungagauuaccaaagacuucaucaucaaagucaungaccggungagcaaggaugagcuagu
caaauungagccagggcagucucacgcgggcgugguacaguacagccacaaccagaugcaagagcacgugg
caggacuucaaagaagcugucaagaagcuacaauggauggcugguggcacauucaccggagaagcgcugc
aguacaugcggagccccaacguccgcaacgccacacccggaaccggcuacucccacccacacaaaacaacc
gaanugcccuggucauuacggaugaacauucuaacacucaacaggacacgacaccucucagugugcucugu
ggugcagacauucagguaguuuucugugggaaucaaggauguguuuggcuuuguggcgggcuccgacca
gcucaaugucauuuccugccaaggcuuaucgcaaggucguccagguaucucccuggugaaggagaacuaug
cagagcuucucaaugacgacuuucugaagaacauaacagcccagaucuauauagauaaaaaauguccgga
unauaccuguccaaucacauucuccuccccggcugacaucaccauccugcuagacagcucagccagugucg
gcagccacaacuuucgaaaccaccaaggucuucgccaagcgccuagcugagcgauuccugucagcaggcag
ggcggauccuucccaggaugugcggguggccgugguacauuuauaguggccaggggcagcaacagccag
agucgggcggcucuucauuuucuuacaganuacacagugcuggccagcucuguggacagcauggauuucau
caacgacgccacagacgucaacgaugcucugagcuacgugacucguuucuaccgggaaccucgucauugcc
accaagaagagauuugcuuuuguuuucauuacagcaacucucaaugggccacagcagaggccauugagaag
gcugugcaggaggcccagcgugcaggcauugagaucuuuuguggugguggugggaccccaggugaacgagc
cccacauccgugugcuugucacuggcaagacugcagaguacgacguggccuuuggcgagcgccaccuaun
uccguguaccaaacuaccaggcccuuucuacguguucguacucuaccagacagucuccaggaagguguuc
cacugggcuagagguuccacacacguggcuuugacacacauggcauggagacacauuucaacaggccu
ucccgcccuucccacugacaaaacaggaauaggaaaugugacccaacugguaacucaacugucunuaaag
cggaacgcugagaugcacacucuuugcuuuguguaauguccccuguggcuucaccugagcucuaucuag
aucccuucccuuguuuuuguacaucaugguguuccaucuugcugaccccucccccaucugggacuggaucc
aaucaucucgucuuccuccucacugccccuaaccuauccguguuugucuucacaccaucacugcagunu
ccgucuguguucugucuucaugcucaacaugaagcagaccuucucaugaguucagcuugcuggauuaugg
cuuuuaggaunuugaacacaggaggaguuccaaacacaaacuuggaggagaccccuccucuucaucaggu
gcuugucauuugaccuacaugcaucuuggucugguccuuauggcuaguccuuccacucugaaagcaaaggu
gcuaucuaucuguaaaggcucucucuacacacccauuaggcunagcuuagacaguucacacucaagu
guccugucagaaucaauccagagcuuucucccucaaaauagugacuugucucccccugguccccaaaggc
uccccuuuaguuaguuucuucauggcucccccacauuccccguaaucuuuauccaagccagcuaucucug
cuaauaaagguuuccauuuuucaaaaaaaaaaaaaa
Tnc/ 17 accccaugccccacccccaccuucgauguuuugaacauuucuaacaacug 252
Tenascin C aagccaguaaagucauauucuuuaaauuuccaggacauucauauuauuc
AV230686 acauaaucauggucauagugaugauauaaacugaggacuutuaaagaga
X56304 uuuucccuucccaaacguuucuggacaguaccugauuguauuuuuuuu
guuuuguuuuuguuuuuaauaaaagcacaguacuutuucc
Krt2-6a/ 10 Sequence below. 253
Keratin gucugcccugccguuuuuacuucccagccuucucaucuccaggaaccaugucuaccaaaaccaccaucaaa
complex 2, agucaaaccagccaccguguucuacagugccagcucagccagaguuucuuguuacucaaccgcucgguucuu
basic, gene cagcaguguguccgugugccgcucccgggacaacgguggcuccagugcaauguguauaggagcuggcu
6a (keratin uuggcagcaggagccucuaugguguggggagcuccaagaggaucuccaucggagggggcagcuguggcauu
6a) gggaggaggcuauggcagccgauucggaggaagcuucggcauugugguggagcuuuguaguggcuuuggcu
K02108 ucguuugguggagcuggcuuuggugguggcuaugguuggagcuggcuucccgaugugcccacuuggaggc
uauccaagaguuucaccaucaaccagagccuccucacaccccugaaccugcaaauugaccccaccaccagc
gggucaggacugaggagagggagcagaucaagacccucaauaacaaguuuugccuccuucaucgacaagg
agagcccauguuugagcaguacaucaggaaccuccgcagacagcuggacagcaucauuuggagauuagga
gucugcgguucauggagcagcagaacaaggucauggacaccaagugggcccugcugcaagagcaggacacc
aagaccgugaggcagaacaugcauuuaacucagagcugaggaacaugcaggaacucguagaagaacuacgg
aacaaauaugaagaugaaaucaacaagcgcacagacgcagagaaugaauucgugacccugaagaaggaugu
gagaugcugccuacaugaacaaaguuugaacugcaagccaaggcagacagucuaacagaugauaucaacuu
ccuugauuagcucucuaugaagcagaacugucucagaugcaaacucacaucucagacacaucuguauccu
cuccauggucaacaaccguagccucguccuagacagcaucaucgcugaggucaaggcccaguuugaggu
cauagcuagagaagucgggcugaagcugagucauuguaccagacuaaauaugaggagcugcaggucaca
gcuggcagacauggggacgaccugcgcaacaccaagcaggagauugcugagaucaaccgcauuuauccag
aggcugagaucugagaucgaccacguuaagaagcagugugccaaccugcaagcugcuauuugcugaugcug
agcaacguggggagauggcccugaaggaugcaaggggcaagcuggaagggcuggaggaugcccugcaaaaa
gccaaacaggacauggccauacugcugaaggaguaccaugaacucaugaaugucaagcuggcccuugaugu
aggaaauugccaccuacaggaagcugcuggaaggagaggagugcagguugaauggugaagguguuggac
caguucaacaucucuguggugcaguccaccguguccagcggcuauggcagugccuaggggugccagcagc
agcuuuaggcauggauggaggcagcagcuacuccuauagcagcagccauagccuuggagguggcuuucagu
gcuggcaguggcaggccaucggagguggccucagcucuucugguggccucagcucuucuaccaucaaauua
caccaccaccuccuccagcaagaagagcuacaggcaguugaauucugucaccaagagcuugucucuggucc
cagaugucauggcugcagcugaaccacaugcuuugguucccggaagggaacgaaucccaaccucuggccuc
cccauggcucaguuucuacauuuguguuugcacgucagcaccuauacauguucuuuugguaacccagaccc
caaaauguugcagaauguagaccuccaagacgaaaccccaaacccuacccagaauacccaccuuaaauuc
ugucaugguuucugacuuccuccagagucuguaaaauaaaaugcccccacaacaaac
Channel-related.
Potassium 14 uuuuuuuuuuuuuuuuugauuuuaauuacaaacuuuauuuguccuc 254
channel, caguucacaguuuauacgugguacaucccaccaugucagcuuccaga
subfamily acggcuauucaggagauggguggagcuuucuuuguaaaggaacccga
K, member cauuuuaaaauuuugguuagaaucuucauagguuuauaaaaguacuc
2 ucugcaaacgaacuggauauauuuacauuuuagcuuaaauucaaau
AI849601 uuuggaaaauaggaaucuuuuuguguuuauuaaacauccuggguuua
ugucuuaagacuuuacucugaaugccacaugaucacguaagcccaag
ccucccccagaagggaaaaaucaguuuugc
Skd3/ 4 uuuuuuuuuuuuuuuuugggugccaugccacagcaaggggccuuua 255
Suppressor uuuaaauguucagggcacagacaaauggaugcuagaugguguagcaca
of K + ccuucucaggguggaguggugccuggauguccaguuuugcgggucuu
transport gcuguccuuaucaaugaucuccaguucgcaauguagguggacgcuucuu
defect 3 cagccugggaugagagcagcucacggcucuuaaggaggugcuuuguc
AI837887 cgaauccuccacagugauacccagggugcaacccccugg
Clic4/ 3 uuuuuuuuuuuuuuucugacacaguaguaauccuuccagacuccuu 256
Chloride acacaauauuacaacucccccaguacauaaauguuccuauaccaugca
intracellular cacagcaacaugggguccacuaaugucgcaggcgacuuuucuaaugg
channel 4 uggaacauagcaccucaaguucugccaucuacacagugaagggacgu
(mito- gauggucggggcuccagagugacagcaaacugccucuugggugacac
chondrial.) gcuuguggcgaagugccucc
AI845237
Col18a1/ 5 Sequence below. 257
Endostatin gagaauauuugcugaggaggugaggcugcugcagcuccuugaagacccccuaccugagaagaucucacaaa
(alpha ucgaugacccucacgucgggccggccuacaucuuuggaccaaacuccaacaguggccagguggcccaguau
1 (XVIII) cauuucccaaaacucuucuuccgggacuuuucgcugcuguuucauguccggccagccacagaggcagcag
collagen) gggugcuauuugccaucacagaugcugcccagguaguagucucacugggcgugaagcucucagagguccga
L22545 gauagacagcaaaacaucucauuacucuacacggagccuggggccagccagacccagacgggagccagcuu
ccgccuaccugcauuuguugggcaguggacacacuucgcgcucagcgucgacggaggcucuguggcucucu
uguagacugugaagaauuccagagguuuugccauuugcucgggccucgcagggacuggagcuagagcgug
gcgcuggccucuuugugguuucaggcuggaacagcagacccugacaaguuccaggggaugaucucagagc
ugauguacgcaaaaccccccgggugagcccugugcacugucuggaugaagaagaugaugaugaagaccgg
gcaucuggagauuuuggaaguggcuuugaagaaagcagcaagucacacaaggaggauacaucucuacuac
cugggcucccucagccaccuccugucacuuccccaccccuguucuggaggcagcaccacagaagauccua
gaacagaagaaacggaggaagacgccgauguauuauucuauaggagcugagacccuuccuggcacagguu
ucaagcgaugcaugggaugaagcuauccagaaccccggaaagggcuugaaaagggagguaugaaaggac
aaaagggagaaccaggugcccaguugcccaccuggcccagcuggcccccaggguccugccgguccaguggu
ccagauucccaacucacaaccugucccuggagcacaaguuacccccguugaccucagguugccaccaguga
aggauggcacuccaggaagggauggugaaccagguugacccuggugaagauaggagaccggguaacacua
gaccucaaggcuuuccagggaccccaggagaugugggcccuaagggcgagaagggagauccugguuuauu
ggggccccgaggaccuccagggccuccagggccaccaggacccuccuucagacaagacaagcugaccuucau
ugacauggagggauccgguuucagcggagacauagagaaccuuagaggcccacaaggcuuucccugg
uccccccggggcccccuggugucccaauacuuccuggugagccaagacgcuuuggaucaaugguuccua
cugcaccaggaccugcaggccuuccugguguaccugggaaggaaggaccccccgguuuuccaggucccccg
ggaccuccagguccuccaggcaaagagggcccaccaggaguggccggccagaaaggcaguguugugaugug
cggcacccaagacccaaggggagcaaaggagaccuuugggcccaucgguaugccuggcaaguucuggcuu
ggcuggauccccuaggcaguuggacccccaggaccuccagggccuccagggccaccaggaccaggauuugc
ugcuggauucgaugauauggaaggcucuggaauaccccucuggacaacagcccgaagcucugaugggcugc
agggaccucccgggcgccgggacucaagggggaucuggaguguucaggccuaccuguuagccaaggga
gaaguuuugagcagauggagcccagggcaucccuggucccccaggaagagaagguuugcagcuggaucuc
cggggccaaaaggagagaaggggaugccgggagaaaagggaaacccaggaaaagauggagugggccggc
cgggccucccugggccuccagugccuccagggcuggugaucuaugugucaagugaggauaaagcaauag
ugagcacgccaggaccuuuagggcaagccaguuguacgcaggcuuuccuggaccugcuggaccgaaggu
ugaccuggguuccaaaggcgaacaggguucuuccgggguuuaagggugagaagggagagccaggcacuauc
uuuuaguccugauggcagacgucugggccauccccagagggagccaagggagagccaguucuuucgagga
cccccggguccuuauggacgaccugggcacaagggugaaauuggcuucccuggacguuccgggucgaccug
guuaacgaauggcuuaaagggauuagaagggagagccuggauuaugccagccuugguucagcaugagauga
uuaccuggccccccugggccuccaggacccccagguccuccugggaugcccaucuauugacagcaagaga
ggguggggccaccugggccaccagggcaauuccccauuugaccucuuccaccuggaagcggaaaugaaggg
ggacaaggagaccgaggggaugcuggacagaaaggagagaggggagaaccuggggcuccuggugguggauuc
uucagcucaaguuguaccuggcccacccggcccaccuggauacccuggaauuccggguccaaagggagaga
ugcauccgggggccaccuggcccuccuggcccgcaguugaccuccuggcauuggcuaugagggucgccagg
ggucccccaggaccuccaggaccuccaggaccucccuccucccuggcccucacaaacagacugucagugu
uccugguccuccaggcccaccugguccuccagguucccccaggagccauggugccucugcugggcagguga
ggaucuuugggccacauaccagaccaugcuggacaagauccgggaggugccggagggcuggcucaucuuug
uggccgagagggaagagcucuauguacgcguuagaaauggcuuccggaaggugcugcugugggcccggaca
uccuccugagaggcugggcaaugagguggcugcuuuccagcccccauugguccagcuucaugauuggcagu
acucaucaggacuuucagccaguuucuccaccugguggcacugaacaccccccugucuggauugcaugcgu
ggccauacacccggagggaguacuccuauuccacggcacgacccuggcgagcagaugacauccuggccaac
ccaccgcgccugccagaccgccagccuuacccuggaguuccacaucaccacaguuccuaugugcaccugc
cgccagcccgccccacccucucacuugcucauuauccguggaacagauuuccagugcuuuccaacaagccc
gagccguagggcugucaugcaccuuccgggcuuuccuguccucuuaggcuacaggaucucuauagcaucgu
gcgccgugcugaccgggggucugugcccaucgucaaccugaaggacgaggugcuaucucccagcugggac
ucccuguuuucuggcucccagggucaagugcaacccggggcccgcaucuuuucuuuugacguucagagau
guccuugagacacccagccuauccacagaagagcguauggcacaucucggaccccagugggcggaggcuaa
ugaagaguuacuugugagacauggcgaacugaaacuacuggggcuacaggucaggccuccucccugcugu
caggcaggcuccuggaacagaaagcugcgagcugccacaacagcuacaucauccugugcauuaagaauag
cuucaugaccucuuucuccaaauaggccucugccagcacaacuccuguauaguucccauuuuuauguaauc
cucaagaaauaaaaggaagccaaagaguaaaaaaaaa
TABLE 5
Genes down-regulated in HF stem cells.
Gene Fold SEQ
Name/protein Decr Sequence ID No.
Growth Factors, Receptors and Downstream genes
GNA-14 32 Sequence below. 258
Mouse G cccugccuuucgcgccgcguuucgccucgcgcuccgcgccucuuucucccuccccucguugguuc
protein alpha cggugguuccucuuccccccuugcuuucugcggcuccuccgcgcggccgguucguuccuucuccc
subunit (GNA- cggucccuuuucgcuccgucgcgguggcccgcccuggccgcugcugcuguuugucuugcggcggcg
14) cccgcgucuccgcgccuccgcgcggcgcucgcgccucccguucgccgcgccccgccggccgcgcg
M80631 ccgggcgcucccgcugcuguugcugggccccggugcgcgugggccccgccccuuucucccgccgc
ugcggcuccucccugggucuggcucccgugcugccgcucgcccgggcuucccgccgcugguuucc
cccccccucuucccggcccugcccgcccuuucuccgcgcccuggcuccccugcggcuccccuccc
uguuuugcgccucuccggccccugccccgcuccuccgggccguggccgucgccccggucccugc
cccucucucgcgccccgguggccgcccucccgccgcuguggcuggcucccggccucccggcgugu
uccgcccggcggcgggcguccccgcuguccgccucugcccccucuucccugccggcccuugcgc
cgucucgccugcccucuuuucgugcccccccccccggcugugcuucguguucgcuuugcccccc
ccuggccuccuucuuccucucccuucuucccuggccccccuccuucuuccgccugguggcuguu
gguggcccgcgcuucugcccgccggcccuggcuuucccugcuuugcgguguccccucccuccuuu
cuucuugguugcucugcgugccucugccccgguuucuggcugcgugugccccugcgccccgccu
ggcggcgcgccccgcccuguuucgcccccuccuccccucccccugguuucugcccuccuccgug
cuucuguucuuccccccgccggcucuucucgcggcgccccuccuguccucuccucuccuucgcuc
cuuccccgcgucccccggccccccgcccgcugucccgcggcccgggccuuucuccugccgcuguc
ucccgccccgccuccugcccccgcgccgguuucucucuuucucccuucccuuuuugcucccgc
ccccgcgccucuccgcuuuguguuuuucugcuguccccgccccccuccucccgcucccccuccg
ggcguuccccuuggugucccuggcgggccuccuccuccgcgcccgcgggugcucugcgcccuuc
cugccugcucuccccgugcuucuggccccggcccuccggcccuucuugucgccccccggcccgc
gcugggucgugcccugugcccccuccuucccccccccuuuuccgugucuuuccuucuucccugu
cucccucuuuucucgccuuuugguugcccgcuucggucuccuuuuugcgugguucccccucuccu
cuuuuuuuuccccucgucuucccccguucuuuccccccuccugc
Ly6/Lympho- 12 gaauuucccugcaaccuugucuuuagaggaagcaaauuacugguuguuuag 259
cyte antigen 6 gagggagcugugagguuuuuaucugagcagcccuucucugaggaug
complex gacacuucucacacuacaaaguccuguuugcugauucuucuuguuug
X04653 cccuacuauguugcagaaagaacucagggacuuugaguuuuaccagug
cuauggagucccauuagagacuacuugcccaucauuuuaccagccccu
acccugauguuagucuguguuacucaggaggcagcaguuuauuguggg
uucucaaacaaggaaaguaaaaaacaaucuuugcuuacccauucugcc
cuccuaauauugaaaguauggagauccuggguacuaaggucaaugu
gaagacuuccuguugccaggaagaccucugcaaugcagcaguuccca
auggauugcagcaccuggaccauggcagguugugcuucuuuuucagccu
gagcucaguccuccugcagaccaugcucugaugguccucccaaugac
cuccacccuuguccuuuuauccucaugugcaacaauuucuuccugga
gcccucuagugaugaauuaugaguuauagaagcuccaauugugggag
uaguaugugaaauaccauguuuugccuuuauagcccuuucugauuag
guaggugcucuaauccucucuagggcuuuucaagucuguacuuccua
gaaugucauuuuguuuuuggauugcuuucucaugacccuuugaggcaca
caaccagcacaguugaagaggcagaauuccaagauauuaugcuaucac
cauccacacauaaguaucugggguccugcaauguucccacauguauc
cugaugucccccuuuuuguuuuccaauaaacccuuuguucuccc
Bmp4/Bone 11 Sequence below. 260
morphogenetic ggaagaaagagagggagggaaaagagaaggaaggaguagaugugagaggguggugcugagggugg
protein 4 gaaggcaagagcgcgaggccuuugcccggaagcuauugugaguucuugcauccgagcugagagac
L47480 gcccagccuaagacgccuuucgcugcaacccagccuaguaucuuggucuuccgucccugauggg
auucucguucuaaaccgucuuuggagccugcagcgauccagucucuguucccuucgaccagguuc
auugcagcuuucuagagguccccagaagcagcugcuggcgagcccgcuucugcaggaaccaaugg
gaggcaaaaguuggccuauuccuccuuccuuucuccaacaguguuugaagguauugauaauugga
uauguuuucugcgucuaucauuccuacuuuagggaggugcgggccaggagaggcgggaaggag
agaaggcugagcagggcaaccuggagaggggcgcuauuucugaguuauucgaguuugcacccgu
aguagaagcuggggauggggcucaggcuguaaccuaaaaggcaccuccauaggccuuggaagaga
gggucauugguuaauuaacuguuuggguauuuuguggguuugcuuccacuuagacuauaagauuu
gggagaguuagggagucaacucuaaguuucaacaccaguuuggggacugaggacuugcuucauuu
aggauuagagaaccuagccagaacuuagcuuugcaaaagaggcuuguccugcuuugcucuaaagc
gcgacccgggauagagaggcuuccuugagcggggugucaccuuuaucuuguccccuacgcaccc
ccucccagccccugagagcuagcgaacuguagguacacaacucgcucccaucuccaggagcuau
uuucuuagacauggacacccauaauuucugccuucugguacucuccccucccuauugaaagauu
guguuaagguuccgacggaaccguggccaggaugccgaauuggcuaccugugcgggucuacugcc
augcagugucugugcggacaugccagcagggcuauuugaggagcuugcgauacuccaaaggguu
cgggaauugcgggguccuuacacgcaguggaguugggccccuuuuacucagaagguuuccgc
cacggcuuuguuuugauaguuuuuuuuaguauccugguuuaugaacugaagguuuuuuugagau
guugaaucacuagcagggucauauuuuggcauuaccgaggcuacuauaaaauuuagguuuuaga
agaagauuucaggggagaaagugaaggguauucugccuccaggagcuguaucaaccccauuaaga
aaaaaaaaaauaccaggagauugaaauuacuuugaucuguauuuuuaauuaaaaaaaaucag
ggaagaaauugaguuuauuagaaaguugauccuuuagcgucguucgguuccaugugcccucgcu
cccgcgugcgccagugcuagcauaucuuccauucucuuucccccuuuaaaagcaaauuaaacaa
aucaacaauaagcccuuugcccuuuccauucgcuuucccaguuauuucccagcggcgacucgugu
cggggaauagagaaaucgucucagaaagcugcgcugaugguggugagagcggacugucuuucagg
ggcgcccgcggucucugcacccagggcagcagugugggauggcgcugggcagccaccgccgcca
gggggggggagagguuagguugaaaaccagcuggacacgucgaguuccuaagugaggcaaagagg
cgggaaggacgugacucuccauccuuuacacuucuuucucaaaaguuucccgaaagugccccccg
ccucgaaaacuagggccgguacgggguggagcgggcucuggagcgggggaguccuggguuucgguc
cucggauggaccccgugcaaagaccuguuggauuagaguugcgcuuccgagguuagaacaggc
caggcaucuuaggauagucaguucacccccccccccaaccccacccgaguuguguugguuauuuu
uggaggaaucuuagccgcgauucuguagcugguuaaaaggaggaaaggggugggggaaggaagu
aggcugugcggggguggcgguggggguggaggugguuuaaaaaguaagccaagccagagggagag
gucgagugcaggccgaaagcuguuucggguuuguagacgcuuugugaucgcgcuuugguguc
uccuuucgugccggguaggaguuguuaguuugcauacucugagaucuaaaaaaaaugugaugcgc
ucuuuucuuuggcaugccuguuuagaaucugguccggaguuagaagcucagacguccacccccc
accccccgcccacccccucugccuugaauggcaccgccgaccgguuucugaaggaucugcuuggc
uggagcggacgcugaggguggcagacacgguguggggacucuggcguuggcuacuagacaguac
uuagaagccuuucuucuaucuuuucccacaccgcucaaaccccgacacccccgcgacggacugag
uuggcgacggagucagaucuuuggaugaaaauuuggauccuuaggggucggcugccugucgcuag
aagcauuauuuggccucucggagacccguguggaggaagagcuggagugugcgaguguuuauug
cguguguguguguguguguguguguguguguguguuuugugugugugucugcccuuugagggucc
cuaugcuuuuccuuuucauggaacgcugucgugaggcuuugguaaacugucuuuucgguuccuc
ucucggcugcacuuagcuuugucggcgcuguaaagagacgcgucuuaagugcacccugauccuc
aggcuuagauauccguccccgaaccuggccagaugcauugcacugcgcgccgcagguagagacg
ugccccuguccccugcgugcagcgacuugaccgagaucgcgccaguguggugucccgccgaaag
uuccucaaagaggcggggacauucccagacggcuggggcuccagcugcaggcgcggagguuggcc
ucgcucuaggggcuggacccagccggggugggaggauggaggaggggcgggcgggcuuucggug
aguggggcggggccucuggguccacgugacuccuaggggcuggaagaaaauagagccugucugcu
ccagagucuucauuauaucaaauaucauuuuggagccauuccguagugccauucgugcgacgc
acugcucauuucucugagccuuuccagcauaguuuguuaagauuggcuccaagaaucauggacu
guuauuaugccuuguuuucugucagugaguagacaccucuucuuucccuuuugggauuucacu
cuguccucccaucccugaccacugucuugucccucccgucggauuccauuucagugccccgcg
cccuacucucaguagcuuaugguuucuuucuggucccuuaaggccagacauacgaaauguacgg
gcuccuuuuuuagcgcucccacuguuuucucugauccgcugcaugcaaaaaagagggaacgcg
agagaccaaauagaugaaagauccucagguugaggcugucccuugaagggcuaaccacuccc
uuucagucccgauauauccacuagccugggaaggccaguuccuugccucauaaaaaauuuaaa
aaaaacaauauaauagucguuuuggaacaagacucuuuuagugagcauuuuaacuagcgaccaca
augaaauaaaucacaaaaucacuggagcagcccuagacuccuuuucccagucacugaaccuugc
ugcccaguccaagcccuaccagcacauuucuguucuccccuccuccuguucuuaaccauuuggaa
gguuguggaaauugggcuggagggcggaggaagggcgggggugguuggggugugaagguggggg
guuggggaggcuuagguccgaagugaagagcuuuggcauuuuaauucucccuccuccuccccccu
uuuccuccucaauguuauuguuuauccuugaagaagccacgcugagaucauagcucagauaaccg
uuggacaggauggaggcuaucuuauuugggguuauuugaguguaaacaaguuagaccaaguaauu
uagggcgauucuuuuuucgggccgugcauggcugcagcugguguguguguguguagggugugaggg
agaaauacaaacuugaucuuuucggaccguuuucaucuuugaccguaguuugcuaccccuaua
gcauaugcagagacaucucuauuucucgcuauugauuuuuauuuauuuuuaaccuuccaccccau
ccccuccccagagacaccaugauuccugguaaccgaaugcugauggucguuuuauuaugccaag
uccugcuaggaggcgcgagccauguaguuugauaccugagaccgggaagaaaaaagucucgagau
ucaggucaucgggaggacucgcucagguagaucauugcuccuguggacuucgaggcgacacuuc
uacagauguuugggcugcgccgccguccgcagccuagcaagagcgccgucauuccggauuuauga
gggaucuuuucggcuccagucuggggaggaggaggaggaagagcagagccagggaaccgggcuug
aguacccggagcgucccgccaucgagccaacacugugaggaguuuccucacgaagguaguuuugcu
cuuaguccuuugcgguguaggguggguuagagcuccguuggagaggguggggagugggcagcug
gcaggacaagcugaagggguuguggaagcccccggggaagaagaguuucauguuuaucaaagc
uccgaguccuggagacuguggauagggccucuuaccuucaacuuucagagcugccucugagggua
cuuucuggagaccaaguagugguggugaugggugagguugguuacuuugugauauggacugaca
ccacucagacuucugcuaccucccagugguuguucuuuagcuauaccaaagucagagauucugc
ccguuuuuguuccaaagcaccuacugaauuuaauauuacaucuguguguuugucagguuuauca
auuaggggccuuguaauacgaucugaauguuuccuagcggauguuucuuuuccaaaguaaau
cugaguuuauuaauuccuccagcaucauuacuguguuggaauuuuauuuuucccuucuguaacau
gaucaacaaagcguacucuguuguuccacuuguaaagaaaacuguacacaaagccaagaggggg
cuuuaaaaggggaguccaagggugguggaguaaaagaguugacacauggaaauuuauuaguuca
uauaaaggaguuuugggagauacuuucuuuucuuuggaguuugacaaauguuuagcuaagauuau
aaagcagaauucaaccaauucugcuauuuuuuguauuuguuucuuuguuuuuguuuuguuugguu
uuuuauuuuuuuuuuuuuuuuuuugucucagaaaagcucaugguuccuuuuucuuuuuccccau
ucaacugugccuagaacaucuggagaacaucccgggaccaguaagagcucuugcuuuuucguuuu
accucuuucaaccucaacaacaucccagaaaaugaggugaucuccuucggcagagcuccggcucu
uucgggagcagguggaccagggcccugacugggaacagggcuuccaccguauaaacauuuaugag
guuaugaagcccccagcagaaaugguuccuggacaccucaucacacgacuacuggacaccagacu
aguccaucacaaugugacacgugggaaacuuucgaugugagcccugcaguccuucgcuggaccc
gggaaaagcaacccaauuauugggcuuggccauuugaggugacucaccuccaccagacacggacc
ucaccagggccagcaugucagaaucagccgaucgauaccucaagggaguggagauugggcccaa
cuccgcccccuccuggucacuuauggccaugauggccggguuccauuaccuugacccgcaggauu
ggccaaacguagucccaagcauucacccacagcaguccaggaaaaaaaauaagaacugccgucgc
cauucacuauacguggacuucagugacgugggcaggaaugauuggauuguggccccacccggc
auaccaggccuucuacugccaaggggacugacccuuuccacuggcugacaccucaacucaaccaa
ccaugccauugugcagacccuagucaacucuguuauucuaguaucccuaaggccuguuguguc
cccacuaaacuugagugccauuuccauauuuguuaccuggauaaguaugacaagguauuguuuga
aaaauuaucaagagauggugguagagggguguggaugccgcugagaucagacaguccggaggg
cggacacacacacacacacacacacacacacacacacacacacacacacguucccauucaacca
ccuacacauaccacacaaacugcuucccuauagcuggacuuuuaucuuuaaaaaaaaaaaaaga
aagaaagaaagaaauaagaaaaaaaaugaaagacagaaaagaaaaaaaaaacccuaaacaacuca
ccuuuaccauauuaaugacuuacgugcaaauuuuaugaccauauagaucauauouugacaaauaua
uuuauuaacaacauuauuaaaagaaaauaaaaugag
IL1r2/Inter- 11 gaauucccacuuacaugcgaacaucucuauauuacauccucaauucuauc 261
leukin 1 cccucgaanccacggacuuaucagucaaucaauacaacagucaaaga
receptor, type auuuuuucuacguuauccuggagcauugcgcuggcaccucuuuuu
II cuaaucaucuuaguugugaggccaauuauagaugcgcagacgguaua
AV223216 aacgcagggcaggaaagacauuauggacugaccaagcuacggacugac
X59769 aaccaggacuucccuuccagcccaaacuaaauaaaggaaaugaa
Wnt3a/wing- 4 Sequence below. 262
less-related gaauucauugucuuaccuuaggcagagggcccagcgccacugcagccgcgccaccucccagggc
MMTV cgggccagcccaggcguccgcgcucucgggauggacuccccccgcuacgcgcucaagccggcgaug
integration site gcuccucucggauaccucuuagugcucugcagccugaagcaggcucagggcagcaacccgaucu
3A ggugguccuuggcugugggaccccagacaccacucugagcacucagcccauucucugugccagca
X56842 ucccaggccugguaccgaagcagcugcgcuucugcaggaacuacguggagaucaugcccagcgug
agcugaguugugucaaagcgggcauccaggaguuuccagcaccaguccgaggccggcguuggaacu
uucaccaccgacagcacagccuggccaucuuuggcccuguucuggacaaagccacccgggaguca
gcgagggcuggaaguggggcggcuguagugaggacauugaauuuggaggaauggucucucgggag
uugccuuuguccaugccaucgccuccgcuggaguagcuuucgcaguaacacccuccuguacagagg
cgaucauugcuaucuguggcugcagcagccgccuccacggcuccccagugccgaugccagggaga
accggccggaugcccgcucugccaugaaccgucacaacaaugaggcugggcgccaggccaucgcc
agucacaugcacucaaguuucaaaugccacuuggcuaucuguagcugugaagugaagaccugcug
gguggucgcagccggacuuccgcaccaucggggauuuccucaaggacaaguaugacagugccuc
ggagauggugguagagaaacaccgagagucucguggcuggguggagacccugaggccacguuac
acguacuucaaggugccgacagaacgcgaccuggucuacuacgaggccucacccaacuuugcaa
ccuaaccccgaaacugcuccuucgggacgcgugaccgcaccuguaugugauucgcauggcauag
auguugugcgaccuguugugcugcgcacgcgggcauaacacgcgcacucagcgacggacggacaa
augccacugucuuuuccauuggugcugcuacgucagcugccaggagugcacacgugucuaugac
gugcacaccugcaaguaggagagcuccuaacacgggagcaggguucauuccuggguaagguuccu
aaccugguuggcguugguuccuacuuggagguugucucuuuacuuggugacuuguucuuacuug
agggcggagauccuaccugugagggucucauaccuaacgacccaguuuugccuucagccucggcu
ccuauuuugagaucuggguuccuuuuuaggggagaagcuccugucugggauacggguuucugcc
cgaggguggggcuccacuuggggauggaauuccaauuugggccggaaguccuaccucaauggcu
uggacuccucucuuuuccuacagggcuuaauggagacagguaacuacucccucaacuagcugg
gguucgugcggaugggucggagcggagagauuagcaucccuccucccagaggcacugcucua
ucuagauacaugagagggugcuucagggugggcccuauuugggcuugaggaucccgugggggcg
gggcuucaccccgacuggguggaacuuuuggagacccccuuccacuggggcaaggcuucacu
gaagacucaugggauggagcuccacggaaggaggaguuccucagcgagccucggcucugagcag
gccauccagcucccaucuggccccuuuccaguccuaguguaagguucaaccugcaagccucauc
ugcgcagagcaggaucuccuggcagaaugaggcauggagaagaacucaggggugauaccaagac
ccuaacaaaccccgugccuggguaccucuuuuaaagcucugcaccccuucuucaagggcuuuccu
gagucuccuuggcagaguuuccugaggaagauuugcagucccccauguucaagugaacaccuua
gaacagaacagacucuauccugaguagagagguucucuaggaaucucuauggggacugcuaggaa
cggauccugggcaugacagccucguaugauagccugcauccgcucugacacuuaauacucagau
cucccgggaaacccagcucauccgguccgugauguccaugccccaaaugccucagagauguugc
ucacuuuuuaguuguauuuaacuucggagacaugggucacagucaugccgcagagccaggguug
uuucaggacccaucugauuccccagagcugcuguugaggcaauggucaccagauccguugccc
accacccugucccgagcuucucuagugucugucuggccuggaagugaggugcuacauacagcc
caucugccacaagagcuuccugauugguaccacugugaaccgucccucccccuccagacagguu
gagguugauguggccauacaggauuugugcccggagagcuggaaagaguagagaggcugcacac
gcgugguaacugacugucuucuaccuggaacuuugccuucgcgcuuguaacuuuuuuuucaauc
cugcuauauccacccaccacuggauuuagacaaaagugauuuucuuuuuuuuuuuuucuuuucu
uucuaugaaagaaauuauuuuaguuuauaguauguuuguuucaaauaauuugggaaaguaaaaag
agagaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
Il12rb2/ 3 Sequence below. 263
interleukin 12 cgcaccggagguccacacugccgcguggacuccagcgauggcgcugcgcuaggcuagcgggugcc
receptor, beta 2 aggaucccucucugcguccugugcugggaagagcucuggagaaccagaguugcauucuggaguug
U64199 caagacucauggcacagacuguuagagaaugucauuggcacuucuuuuuuuuguucauguggcu
ugcugauuaaagcaaauauagaugugugcaagcuuggcacugugaccgccagccugccccucuga
aucccaguucuaacgaauuaauccucuuaaaguuugucaaugauguccuuguugaaaaucuccaug
agcuuccucuucggucagcugccuauauuuccugcuccuugaaucccaagcaaggcuguucacauu
aaagaaaguccaugccacacuuugucacuccuccacuuuucaagucaccaaccuuuucccuuggu
uaugaccuuguuugucugcaagcuaaacuguacaacucucaaaagaagccaccaauccaguaugu
gggguagagaucucaguuggucuugcuccagaaccaccucaaaacaaucauguguccaggaagg
agaaaauggaacuguggccuguuccuggaacucuggaaaaguuacuuaucugaaaaccaauua
cacuuuuacaguuaaguggaccaaacaaucugaccugucagaaacaauguuuuucugacaauc
cgucagaauugcaaucgccuggaucuugggaucaaucuaagcccuaauuuuagcugaauccauuu
cauuuccguguuuacugccaucaacgaucuuggaaaaucuucuuucacuuccgcauacguucac
guucuaggacauagugaucccucuuccuccgugggacaucagaaucaacuauuaaaugcuucugg
agagcagagguacacugcagugggaagaugagguggcaagugguacucaaucaacucagauauc
agccucuuaacagcacguccuggaacauggucaaugcuacaaaugccaaaggaaaauaugaccu
guagaucugagaccguuuuacagaauaugaauaucaaaucuccucuaagcuacaucucucug
gaggaaguuggaguaauaggagagagucacugagaacacgacaccagaggaagagccuguuggg
auauuuagacaucugguacaugaaacaagacaucgacuaugacagacagcagaucucucuuuuu
cuggaagagucuuuaauccaucagaggcaagggggaagauccuccacuaucaguuugacguuac
aagaggugacaaagaaaacaacacuugcagaauacuacaaaacacaccuccuggaccagggucau
cccccgaacuggggcuuggacggcaucaaugucugcagccaacucaaaaggcgcuucugcacc
cacucacauuaacauaguggaccuauguggcacugguguugcuggcuccucaccaggucucugc
aaagucguuagaacauggacaacauucuagugaccuuugcagccuccuaagaaagcugauuucu
gcuguucaggaguacauaguggaauuauagagcucuccaaccagauagcaucacgaaguuuuc
ccccacacuggcuacggauccccccggacaacaugucugcucugauuucagagaacauaaagc
ccuauaucaguuaugaaaucagggugcaugcacugucagagagccaaggagggugcagcucca
uccggggugacuccaagcacaaagcaccagugaguggcccucacauuacugccaucacagagaa
aaaggaacgccuuuuucauuuccuggacccacauuccauucccauagcaaaggaucugcauccu
ccauuuacagaauauacuagaaagaacgagacucgacagcacaaccugagcucuugcgaaauuc
aguaccgacgcucacaaaacucacauccaauuaagcagccuacagcccagggugacauaugucc
uauggaugacagcugugacagcugcuggugaaaguccccaaggaaaugaaagggaauuuuugu
cccacagggcaaagccaacuagaaagcauucgugauaucaagcauuuacaucgcuaucaucacg
guaugcacguucucaaaucguuuucuuccggcaaaaggcauauacucaccugucuacucuuca
aaaccucaaugguauagcagaaccauuccagaucagcaaacagcacuuggguaaagaaguaucc
acauucuggaggagaagauccagcuaccuacggauaaucuccugauggcauggcccacuccugaa
gagccugagccccugaucauccaugaaguccucuaccacaugaucccaguugucagacaaccau
auucuuucaaaagaggccaaggauuuccaaggcuacucuaccuccaagcaagaugcaauguau
auuugccaauccacaagcuacaggacucucacagcugagaccagacaacuagugaaccuauaca
aggugcuagaaagcagagacccugacucaaaacuggccaaccugaccagccccuuuuacaguc
accccauuugaacuaccuuccuagccaugaaggcuauuuuacccuccaacauagaagaucuguc
accacaugaggcugacccaacgauuucuuuuugaccuggagcaucaacauauuuuucucuuucc
auuuuugcaucaaguucucuccgcccacucaucuucgguggugagcggcugacucuagaucgguu
aaagaugggcuaugacucccucaugaguaaugaggcuuuuauacuagaaagccaacguaccucau
uuuaucugcccaguuccuacuccaaaggucugugacagugaagacaagccagcugucucuugga
uuaaaauuagcuuucaccauagguacuuaagucuuauauauuaagguggcaauacaccaacacuu
gauaucauauagaaaggaccccaagauagucaugcuc
Wnt10a/Wing- 3 Sequence below. 264
less-related ggcacgaguucacccucugcaugcguuccccuccccccucuccagcaaacacggcgcgccagucc
MMTV aaagcggacucaguggccucgguugacgggagcaugccaccuccuuuggugacgucacuugguug
integration site auagaacccuuagacacuacaugguugggggguuggucagaacucccgagccaggacagucacuc
10a acuucuucaggcaguggggcugggccagacaguaccgcccccaccgcacccgccucgcacacccu
U61969 cggaagcgcaggcucgcagcgcggcgcugguggugggggguugcgccccagaacuucggccucca
aguccccagcccgcugcaccuccuuacccucuagaggcccccucccccuuuacccucuagaggc
accaguuaguuuucgcaaggggcccuuggaaauucccuggaccccugugccaggaaugcccauuc
gcccgcuccccauccacccccccgagggcggagcccggaugcgcugccccauggagcggggaggc
gggcgccgucagcagcgggagcugugaccugaguaggagcagugugucgcagccgccccacccc
ugccgaucaugcgccucgacccugguucgccagucccacugggcugugagccccccacuccuggc
ccugucacggcccgcgcgccaugggcagcacccacccucaccccuggcuacggcucccacaaggg
ccccagccgcagccugauuucuaggcgcuccuguucuuccuacugcugcuggcugccgcugugcc
caggucagcacccaacgacauccugggccuccgccuaccccagagcccgugcucaacgccaacaca
ugugugccugacauuuucccggccugagccggcggcagauggaggugugugugcgucacccugacg
uggccgccucugcuauccagggcauccauucgccauccaugauuugccagcaucauuuuccgggac
cagcgcuucgccuacgccauagcagcugccgggguggugcacgcaguguccaacgcgugcgcucu
ggguaaacugaggcuugcgguuucgacgccuccagacguggguuacuagaagcuuuccgucguag
cugcaccgcuuugcagcuggacgcgcuuucagcgcggaaagggcuugagccacggggucccugaac
cacccggccauacuuuccugccagcccaggucugcaggacuccuaugaguaggguggcugcaguc
cggauguaugcuucggagaacgcuucucuaaggacuuucuggacucccgagagccucacagaga
ccauccaugcucuuaaugagacuccacaacaaccgugugggccuugcaggcggugauggagaac
auuucggcguaagugcaaaugccacggcaccucaggcagcugccagcucaagaccugcuaucagg
ugacgccugaguuuccgcacaguagggggcgcugcuacgcaaccauuccaccgcgccacgcucau
ccggccgcacaaccgcaacgguggccagcuggagcccggccccgcgggagcacccucgccagc
accgggcacuccagggcuuucgccgcagguuccagccacuccgaccuggucuacuuugagaaa
ucucccgacuucuguuuaggcgagccgcgccuggacucggcaggcacuguugggcaccugug
caauaauuagcagcacgggucccgauggcugcggcagcaugugcuguggccgcggccacaacau
ucugcgccagacgcgcagcgagcgcugccacugccgguuccacuggugcugcuucguuucugcga
agaaugccgcaucaccgagugggucagcgucugcaugugagcagacccaagcuccucugggucuc
aagaaugguuuguccucuuuauugccuggcuucugccgcuagcagaucugaaccaggcagcaagc
agcagccuuuggcuuccugagagaggugguuggcucuuacagccccgagggucuacaaucacca
gacaguccagaucugauugacauuccuccgcucaccucuguagguuccccucuuucuguuccua
gcucagacagcugggggugauaguggagacuguuccacacccuaggacaggucaccaaagcagc
ccagccuguucaugccuaccuccuuuucaucucuucuucccuuccccaggagugauaggcaaug
cacugaagcugaugggcaccggggaagaaaacuaaaaggcagaaauggccgucaucgggcugaa
gugacucuaagggcuccagaccucugcuccugucuuucacuuaacagauauuuauuuuugcgcu
cucuuugagacacucucuggggaaaaauuaauucuccggagucuacaggcugauuaagguuacau
ggacaauaaaccaguaaacacacaaaaaaaaaaaaaaaaaa
Ifngr2/Inter- 3 Sequence below. 265
feron-gamma gaauuccgggccgcuugcacuuggcgacuagucugcggcggacgugacgccaaggccacguugca
receptor ggcgcggguccccugucaaggugucccucgcgcaggaauaugcccgcaggcggcagcuggcagga
precursor ugauucuacuggugguuccuugaugcugucuacgaaggucgggaguggagcuuugacgagcaccg
M28233 gaggauccugagccucccucggugccuguaccgacgaauguucuaauuaaucuuauaacuugaac
ccugucguaugcugggaauaccagaacaugucacagacuccuauuuuuuacuguacagguaaagg
uguauucggguuccuggacugauuccugcaccaacauuucuuuaucauuuuuuguaauaucuauga
gacaaauuauguauccugauguaucugccugggccagaguuaaagcuaagguuggacaaaaagaa
cucugacuaugcacggucaaaagaguuccuuauguccuaaaguugaaaggucgggcccccuggcc
uggagaucaggaggaagaaggaagaacagcucuccguccucguauuucaccugaagucguugug
aauuugagagagccagggaaccauguuuguuugacgggagcaccuguuacacauucgacuauacu
aguguauguagagcauaaccauaguauggagauuccuuacauacgaaacauacggucgaaaaauu
auuaguguaaugagacucuuguaugaguuaaacaucucaguauccacacuggauuccagauauug
uauuucaguagacguuaaucucaucuuucuggcaaguuagacauaaaaucgaaagacgucugua
ucccuccuuuccaugaugacagaaaggauucaauuuggauucuguugguuuucuccucuuaccg
ucuuuacaguaguuauccugguauuuugcguauugguauacuaagaagaauucauucaagauua
caaagcauuaauguuaccuaaguccuugcucucugugguaaaaagugccacguuuagagacaaa
caccugaaucgaaguauucacuugucacaccgcaccagccagcuguccuagagagugagacggug
aucugugaagagccccuguccacagugacagcuccagacagccccgaagcagcagaacaggaag
gaacuuuucaaaagaaacaaaggcucuggaggcuggaggaagcacaucugccaugaccccagac
aaccuccaacuccgacacaaagacgcagcuuuucccuguuaaguaguaucagucaggcccuug
uagccucaccgccuaucacuccgaaacggcucugacaguggccucgugggaucgggcagcucca
uaucggacuuggaaucucucccaaacaacaacucagaaacaaagauggcagagcacgacccucca
cccgugagaaaggcccccauggccuccgguuuaugacaaaccgcacauuguuggugacgugcuug
uggauguuggggggaaggagucucucaugggguauagacucacaggagaggcccaggagcuguc
cuaaggucucccgaggccugcuggugguaaagaaacugaccuuuuaggcaguuuuuucugcauuu
gauuuucaugaaagaagcuauacauuagcuuaauacuaaccacauagaauauucagacuuagau
acgugauaaggauccugugggcacugcuggguccacucugcaaaugccaagacuaucaaaggaa
cguauugucgcuucuggcuccuucccagguaggcuagcauucugugaguuuugccucggcuagc
cuugcuuccuacagccgccacugcuccuccacccugaucaucucacaggacaggguggaccggg
uuuuuuuuuuuuuuuuucacacaccuuuguauauguaaguucauguauauuaauuauguuuuaca
uguuucacuuuugaacugaaagcuacucaaagccagccguaagucuaugguagaaugugaugga
acauguugguggaagcuuuguacaauagaacacauuuggugagagcuuuguacauacuuuuuuau
ggagcauuacuuacgauuuuuuaguaaaauguuuugaaaccaaaaaaaaaaaaaggaauuc
Fgfbp1/ 3 uugagacuccacagccucauccugcucuccuuccuucuccuggcuac 266
Fibroblast ucaggcguucucagaaaaggucagaaagagagccaagaacgcaccac
growth factor acagcacagcggaggaggggguagaggguucagcucccucguuuagg
binding protein gaaggcccagaauaagcagagaagcaggacaucuaaaucucugacgc
1 auggcaaguuugucaccaaagaccaagccacaugcagaugggcugug
AF065441 acugaggaggagcagggcaucagccugaagguccagugcacauagc
cgaucaggaguuuucuuguguuuuugcuuggugacccaacugacugc
cuuaaacacuuacaaagaccagaucuacuggaaacagguugcccgcac
gcugcgcaaacagaaaaauaucugcaggaacgccaagagugucuuga
agaccagagugugcagaaagagauuuuccagagucuaaccucaagcug
gugaaccccaacacacguggaaacacgaagcccaggaaggagaaagc
agaggucuccgcaagggagcacaacaagguccaagaagcugucucca
cggagccaaacagggucaaagaagacaucacacucaauuccagcugcg
acccagaccauggcuuuagagauuccagagugucuagaggauccaga
ugugcucaucagaggaagaccgcccuggaguucuguggggaaucu
uggagcuuccauuugcacauuucuuccucaacauguuacaggcgacauc
augcuaa
Transcription Factors and Related Genes
Klf5/Kruppel- 5 aauucgucgacaugcgccguuccagugcauggugugccaacgcagc 267
like favor 5 uucucccuuccgaccaccucgcgcugcacaugaagcgccaccagaa
AA611766 cugagcgagcgagcgcugccccacccgccugacgccuugcaguccgc
ucugccauccuuuaaaccgcagaccuaacuucauaaaaaga
Gata3/GATA 4 Sequence below. 268
binding protein gcuaaacuaucccgcaaagauuuuucuuuccucccuaaacccuccuuuuuugcucuccuuuucua
3 uacccuuaacugcaaacaaaccauuaaacgaccccucuccugggccuccgacggcaggaguccgc
X55123 ggaccucccaggccgacagcccucccucuacccgcgagguuccgguuccgggcgagagggcgcga
cgcacagccgaggacauggaggugacugcggaccagccgcgcugggugagcaccaucaccccgcg
guccucaacggucaacacccagacacgcaccacccgauccucggccauucauacauauaaacuuc
uaguauccgcugacggaagagguggacguacuuuuuuacaucgauggucaaggcaaccacgucccg
cuccuacuacggaaacuccgcagggcuacggugcagagguauccuccgacccaccacgggagcca
gguaugccgcccgccucugcugcacggaucucugccuggcuggauggcggcaaagcccuugcagc
caccacaccgccuucgcccuggaaccucagccccuucuccaagacguccauccaccacggcucu
aggcaagaugagaaagagugccucaaguaucaggugcagcugccagauagcaugaagcugugacg
aucccggggccucuguccguuuacccuccggcuucauccucuucucuggcggccggccacucca
guccucaucucuucaccuucccgcccaccccgccgaaagacgucuccccagacccgucgcuguc
gcaccccgguguccgccgggucggccucacucucgaggcgcauugaccacccugggugaugccuca
uccucagcccaccaccccauuaccaccuauccgcccuaugugcccgaguuacaacucuggacucu
ucccacccagcagccugcugggaggauccccuaccggguuucggauguaagucgaggcccaaguu
cacgauccacacagaaggcagggagugugugaacugcguuggcaaccucuaccccacuguggcguu
cgagauuuguaccgggcacuaccuuuacaauugccugcggacucuaccauaaaaugaauugggc
auaccggccccuuaucaagcccaagcgaaggcugucagcagcaaggagagcagggacauccugc
gcgaacugucagaccaccaccaccacccucuggaggaggaacgcuaauggggacccggucugcaa
augccuguggucuguacuacaagcuucauaauauuuaacagaccccuucuauugaagaaagaag
agcauccagacccgaaaccggaagaugucuagcaaaucgaaaaagugcaaaaaagugcauugacg
ucgcuagaggacuuccccaaaagcagcuccuucaacccggccgcucucuccagacacaugucaucc
ccugagccacaucucucccuucagccacuccagccacaugcugaccacaccgacgcccaugcauc
cgcccuccggccucuccuucggaccucaccacccuuccagcauggucaccgccauggguuagag
aggcagacccugcuccacaugcgugaggagucuccaagugugcaaauguuccuccgaccccuuuc
uacuuugcguuuuucgcaggagcguaucaugaagcccgaaagcgacagaucuguguuuuuuga
aggcagaaagcaaaauguuuugcuucuuuuuucaaaggagccgagguggugucugcauuccaacc
acugaauccggaucccauuugugaauaagccauucagacuucauauucccuauuuuaaaggguc
ucuagugcugugaaaaaaauauugcugaacauugcauauuaacuuauauuuguaagaaauacug
uacauuuugaggaagacuuuauuguaccuggauagcuguaagaaaggcaugaaggacgccaagag
uuuuaaggaauauagggguuuuaaaguaauuuaaaaaaaaaaaaaagaaaua
Stimulated by 3 Sequence below. 269
retinoic acid caaccaccuccuaccugccugcccaaaacuccagggcuggaacacggagaccugucaaggaugga
14, basic-helix- uuuugcccacauguuaccaaguguacaaguccaggcggggaauuaaaacggagcgaagacagcaag
loop-helix aagaaacuuuuacaaacugccgcaccggcugauuugagaaagagacgugaccggauuaacgagugc
protein gauugcccagcugaagugucuccuacccgaacaucucaaacuuacuacuuuguuucacuuggaaa
Y07836 aagcagugguucuggagcuuacguuugaagcacgugaaauauugacaaaucuuaauugaucagcag
cagcagaaaaucauugcccugcagagcgguuuacaagcuggugauuugucgggaagaaaucucgag
gcagggcaagaaauguucugcucagguuuccagacuugugcccgugagguacuucaguaccuggc
gaagcaugagaacacucgggaccugaaaucuucccagcucgucacucaucuccaucguguguuuc
ucggauugcugcaggguggagcuuccaguaaccauuggacuaugcucccaaagccaucgacuuuaa
gagaagcccagcuuccuagccaagggauucagaaggcccagauaaaaacuaugugccagucauc
cagcggacuuuugcucccucgggugguugagcagagcggcagugacacggacacagacaguguuc
guauggaggugaauuguuagaaaggggacuuucgcagugaacagccguacuucaaaagcgaccaug
ggacgcagguucgccgugggauacgugucauacaauuaagcaagaauccgaagagccccccacca
caaaaagccgaaugcaacuucucagaagaauaaggccacuucacgucaguaucugauggguucccc
auuucuugggccacacccacaucagccuccuuuuugccuucccuucuaucucaucccaccaucg
ccuuugccuaccugccuuaugcuggagaaaugcugguaccccaccucugugccaguguuauucc
caggccuucaacaccucagcugcagcccucuccaacuuauuaacccagacaagauaccgacucc
cuugcuucugccccagagacucccuucuccuuuggcacauucgucccuugacucuucggccuug
cuccaggcuuugaagcagaucccuccuuuaaacuuagaaaccaaagacuaaacucuggagggauc
uuccugcugccuugcuuucuuuccucccuaauuccaaaaaccacgaagguuucccugagugcag
agagauagcccacccugcagacccacagagaagauucaugugugugugagagugagugagugug
cgugcgugcguuuuguuguauguuuguauauguaggacaauaaguuccuuugacacaagggagac
acgagaaggauagccugacaucagaugacagacuggaggacuguagcacaucucugggcguuucc
cuacccagagaagagcc
Cell Cycle Related
Mki67/antigen 4 Sequence below. 270
identified by agucaccgacguuguauaacgacggccagugaauuguaaucgacucacuauagggcgaauugggu
monoclonal accggccccccccucgaggucgacgguaucgauaagcuugauaucgaauuucucguccgcgugcgg
antibody Ki67 ugucuggucggggcggagcgaaggccgcgggggccguguacgguccuccgcggcuaaggagccgag
X82786 cugcuccgacgcgggcugcgcccggugagcggaugccagagcuaauuggcugauuaaccgcugag
gaacggcccggcagggcaacugcgagcuuucaccgagaggcuuuccacccugguccgcagucccg
uacggccgggcggaccauggcguccucggcuucaccuuggucaccaucaagcggagcggcgauga
cggcgcacacucccgcugagccucagcucugccuguuuuguaggaguuugaaugugacauucgua
uccagcugccuguagugucucaaagacauugcccaauuauaguccaagagcaaaaggcgauauua
uuauaauuucaguuucuaccaauccaacucaaguaaacgggguuuacuauagaugagccuguga
uggcugagacauggagacauaauaaccaucauugaccgcuccuuuagguaugaagauggaaauca
ugaggauggaagcaaaccauagaauuuccaggaaagucccuuuggaaaggaaccaucaaggcgag
ccuaagauagcuucugugcugacccugaugggaaaagucaagauaccaaagcuucaaaaaugacu
gcuucaagaagaucuuuuguguaugccaagggccuuucugcagauagcccugccucagauggcu
caaagaacaguguuagccaagacucaucagggcauguagaacagcacacuggcagaaacauagua
cgagcccacuucugggggaucucuuuuuaagaaguccaggucucagggagcagguuacaaggaac
cgaagucuuuuccuacacagaaccuugcaauacaacaaaaagaaaucucccuuuugagaaacuuu
uaucaaucaaugaaggaagaguuggauguaaaaucccagaaaucuuguaggaaaucagaacccca
accugaccgugcagcagaggaaucggggagacacagcuauuuggugucaggcagggcaagagca
aagucuaguggaagcaccccuguuacugcagccuucuucacccaaaguaguaagaucugucugag
aagauggcgcgguguauggugccuguccagacuuccacagagacagcuaaaauuagaccccugug
cggcauucacagcaacuuaaggaugaagacucucguguuacuggcagacgacauucugugaaucu
ggaugaagguggaagugcccaggcaguccauaaaacagucacuccugggaaacuggcgacuagaa
accaaacuccgguggaggcuggggauguuguauccucugauacaccagaacauuccucuuccccc
cagagauguauuccuguaagguagaggcuccaucucagagacacaaaaucggcucucuuuacuc
aacgccuuguccaggugaaaagaaaacucccaaagguuuccuucagcaagccugagaaacuggc
cacagccgccgaacagacuugcuucuggccuaccuggucuuaguuccguugauaucagcaacuu
uggugauuccauuucaagagugagugaaugccuaugaagagaauuuguauccuuuggugucauc
uaagaccugaauuauuuuaaugaaaacuuugccuccuaauacaccacugaaaagagugaaacgc
caaccaagaggaagucucuuggcacucacagcccagcuguccucaagacaaucaucaaggaacgg
ccccagucuccagggaaacaagagucuccugggauaacgccaccgaggacaaaugaucaaagacg
cagaucaggcaggacuuccaguggaagcaauuuauaugugagacagacauucccaagaaauaggc
agaaagagcgguaaccugccugcgaagagagcauccaucagccggagucagcauggcauucuac
agaugauuugcuccaaaaggcgaaguggagcuucugaagccaacuugauuguugcaaaaucaugg
gcugauguuguaaaacuuggcgugaaacaaacacaaacgaaagaugcgaaacaugucccuccaaag
cagacgagcaagagacaaagaagacccagcacuccaaagaaacccacaagcaaucuucacaauca
auuuacuacaggccaugcaaacucucccuguaccauuguaguagguagagcgcagauugaaaaa
guaagugugccugcccgacccuacaaaaugcuugaauuaacuugaugcuaaaccgaaaaguggac
uucagugaagaucugucaggacauuugucugaaagacaauugcaaguaacuaauucaggagacau
uaccugagcccaucaccacagagauuuugggagaaaaaggcuauccaguacucggaaugcagcaaa
augcagcagucugauagauauucuuucaaguccuaccuuaagacggcggauucaucaaugaaaa
ucacagugcaaacuccuaagaauuguccauaacauuuacugaccuugagaagaagacuccgguuu
cucugagacagacccugaagacugcaucgagugugagcaaguuaagaagaucuagagagcucaga
acauacccuuguggaaacuaugaaugaaaaaacagaauucauuuccuugcugagaacaccacagca
agacauuuaagggguuacauuucgauuaacaaaaaguagaucaacagugcaggacaauugaaaac
agcuccucaaagaugcaaagaaaguagugaauuuuaaguaaaaguucagaaaagacaucaacuag
aggagaucaagugccaggaagcagaagccgacaaaagacuuacuaggaagucagauggucaccca
caacagcagacuaugcugaggacuacuuagucaaggacaaggaaccauacaaaaccuagaggaau
ccauuucacaugcaaaacacaucaauaauuugaguuaucagaauuacagaaaagaaaggugaaca
auaauaguauuaugcaaccaaaaagaagcacucgccaaagaccccuggcaaaaaggcaaaccucu
agaagggccagcuggucucaaggaacacuuuugaaacaccaaaccccaaagauuaaaccuauuaa
gcggaagacagaacuagaguccuuugcaaaucaccacaagucacaacagagaauaucacaacaaa
ucacaaauuccacagacuagcacaucuguugaagaaauagacaugaaggaagaaagcucugccu
agugacaaauguauacauuaugccagaugaauccaggcauaaucccaaaauuuaaaacuugagu
cagugaggauuaucaaagcuuuuugaagcaaucugaaaaugaaaugcugaccucaacaguaaaug
agaagcaagagacuuuaggaaaaucuaaaaaaaaggcucagccccuggaagaccugacuuguuu
accaggaacucuuuauaucaccaguuccacuaacauaaucaaaaaaauucccaacaaaucuccac
acacacaaccagucagaaccccagcgagcacaaaggacucuuccaacagguuucucaguaaagu
ggaugugagacaagaaccuucaacacuugggaaaagaacgaagucaccaggcagagccccagg
caccagcaccagugcaggaagaaaauugcugcacagccuacauggaaacuccaaagcagaaacugg
agucuauagaaaauuuaacagggcuuaguuaaacaguccagaacaccuaaagacaucacugguuu
ccaguuauaguuuccaaauaccauuaucaugcuauggcccauuagugguuugucaaaaccaaaaa
aauguucuuuuaauucuccacaaccagaaagugccauaacccgaaagagcagagagagacagucu
agggcaaguauaaguaaaauagauguuaaagaagaacuuuuagaaucagaggaacaccuacaauu
aggagaagguguagacacauuucagguauccaccaacaaagucauuagaucaucuaggaaaccug
ccaaagcguaaacuggauucaacagcuugguauugccuaacagcaagaauaugcgcuauucuuca
uaggaccaguuuagaacccaaaucaacaaaaagagucugcccaagaucaucuugagaaaaauggau
aguaaggauaacacaccaugccuagaaaaccugaauaucuucaagagcucuuccaaaugccaggc
cuaugcuaaugacucuuugaccacuggaaucucaacaaugcuugcuagaucaccacaaugacaga
agaaauuucagucucuuggaagcagucacuuggacaaaguccacaccacacaagagcaggaggau
aaugcaaucaaagcaauuauagagauuggaauuaucacagugucuuccaagaacucuuccaaaca
cucacgcuacuguucugauccauuaauugguaacaaacaaacaagaauguccuugagaucuccac
gaaccaggauuuguuagaacuccacgaaccucaaagagacuuggcuaagacaaguuguuggga
auauugcugugagagaaaagaucuuucuccagugagucugccacagugugcuacaggggagguu
guacacauacccauagggcagaagaugacacagagaacaaaggugugaaggaauccacaccuca
ggacacuggacucaucagcaagucgaacugucagcaaaggcagcaaauggcacaugaagaaagc
cucaauucucaauagacuuauuuucauccccaagagcucuuucaaacaccaaccaguggcaaaga
cccaguaacuguuuugaugaaacuuuacaaaaauagcucugcagucuccacaaccaggacauua
ucauaaacccagcaagcaugaagagacagccaacaugagucucaggaaagacaugagagauuuu
ccauacuugaaaaacaaacacagucacaggcagauuacgcaggcacaccagcaccaugcaggaa
uuaaaauggcaccacagccauuauuugaaacaccaaagcagaaacuggauuuucauaggaa
auuucaacaggacauuaagaggaggccucggacacccaaaaacagggcucagccccuagaagacc
guggaugcuuccaagaacucuuucaaacaccagcuggugccagugacccugugaguguuugaag
aaagugcaaagauaucuuuggcaucuucacaagcagaaccagucagaaccccagcaaguacaaau
uagacgcuccaagacaggucucaguaaaguggaugugagacaaaaaccuucaacacuugggaaaa
cgaaugaagucacuuaagcagagccccaggcacaccagcaccagugcaggaagaaaaugaagcac
cagccuucauggaaacuccaaagagaaacuggauuuucacaggaaauucaucaggacauaagag
gaggccacagacacuaagaucagggcucagccccuagaagaccuggauggcuuccaagaacucuu
ccaaacaccagcuuugugccaaugacucagugacuguuugaggaaaguguaaaaaugucuuuuau
aaaucuucacaagcagaaccagucaaaaccccggcaaQcacaaagagacucuccaagacaggucu
gcaguaagguggaugugagagaagacccuucaauacuugagaaaaaaacaaagucaccaggcac
accgcaccagugcaggaaaaaaaugacugcacagccuucauggaaacuccaaagcagaaacugga
uuucacaggaaauucaucagacauaagaggaggccacggacaccuaagaucagagcucagcccc
auagaagaccuggauggcuuccaagaacucuuccaaacaccagcuggugcuagugacucaguga
cuguugaggaaagugcaaagaugucuuuggaaucuucacaagcaaaaccagucaaaaccccguuc
uaagcacaaagauuacucuccaagacaggucucaguaagguggaugugagagaagacccuucaac
acuugggaaaaaacaaagcaccaggcagagccccaggcacaccagcaccagugcaggaagaaaau
gacagcacagccuucauggaaacuccaaagcagaaacuggauuuugcagagaauucaucagggag
uaagagaaggucacgaacaucuaagaacaggucucagccccagaagaccuuugauggcuuccaa
gaacucuuccaaacaccagcuggugccaguaacccugugauuuguugaagaaagugcaaagauau
cuuuuggaaucuucacaagcagaaccagucagaacccgggcaaacacaaagagacuuuccaaga
caggucucaauaagauggaugugagagaagggcacucuccgcucaguaagucaagcugugcaucac
agaaagucaugcaaacccucacacuuggagaagaucauggcagagagaccaaagaugggaaggu
auuguuagcucagaauuguaccagcaauauauguuacucguggcaagaggcagcaaaggucaugua
agaaaagaucccaguccccagaagaccucucugguauucaggaggucuuccaaacaucaggccau
aacaaggauucagugacaguggacaaucuugcaaaacugcccagcucgucuccaccacuagagcc
aacagacacuucaguaaccucacggagacaggccagaacuuugucuuuaggaaaguucacuuuga
aaaaugaacuuucaggaggcauaaugcauccacaaauaucagaggaaauuguggacuuaccuag
agaaccaaaaagugaaggcaaagucauuaaaacaaggaagcaaucuguaaaacggaaauuggac
acagaagucaaugugccucgcaguaagaggcaaagaauuacaagagcagaaaagacccuagagg
aucugccuggcuuccaagagcucugccaagcuccaagcuugguaauggacucaguuauuguug
agaaaaccccaaagaugcccgacaaaucuccaaaaccuguggauacaacuucagagacacagaca
agaagaagacucaggagacugguuguuacugaagagcccauaccacaaagaaagacuacaagagu
uguaaggcaaaccagaaacacacagaaagagcccauaagugacaaucaagguauuaaggagaaaa
cccaacccuuagaagaacucaccaguuuccaagaggaaacugccaaaagaauaucuuccaaauc
uccacaaccggaagagaaggaaaccuuagcagguuuaaagaggcagcucagaauacaacuaauca
cacgaugguguaaaagaagagcccaagcacagagaaagcaaccauccagggaaaccaggaacaca
cucaaagagccuguaggugacaguauaaauguugaagagguuaagaagucuacaaagcagaaaa
uugauccaguagcaagugugccugucagcaagaggccacggaggguacccaaggaaaaggcaca
cggcccuagaauuggcuggucucaaaagaccaauccaaacccuaggccacacugaugaaucaaca
agugauaaagaaccacacagaugcccuguaauucucuacaaccagagcaaguugacagcuuccaa
ggucccugaaauugguaacaaugguacccaaguuucaaaggccuccauaaagcagacauuagaua
cagagcucaccaaggcgacccaggacaagacgugggaaaguauuaggcagaugaagagccuucagc
caguaagaaagacaguaucaacaucaaggcaaacuaugcgaucccgcaauagccaaaguaacugg
acagcaggaggcagcuaaggacacauaaaggaugggguucaacccucuugaaguuguuaggugac
auccaaagaaauaaccaaauaucagaucacucugagaaacuagcacaugacaccaguauccuuaag
uagcacucaacagcaaaagccagacucaguaaaccucugagaacaugcagaagagugcugaggac
gcucuaaagagauccccaaagaaguguugauggacaccagagaccaugcacauuacaaagcaaaa
gcaacccuuugcuguccccgaagaggaagucugcaagagauggaagcauugugagaaccagggcu
ugcgcucuuuagcaccaaagcaggaagcaacagaugagaagccuguaccugagaaaaaaagggc
ugcuuccagcaagaguauguaucaccugagccugugaagaugaaacaccugaaaaucgugucaa
acaaacuugaaucuguggaagagcagguuagcacuguuaugaaaacagaagaaauggaagccaaa
agagaaaauccugucacuccagaucagaacucuagguaccgaaagaaaaccaauguaaaacagc
caaggcccaaguuugaugcaucugcagagaaugucgggauaaagaaaaacgagaagacuaugaag
uuguaugcaccaagaaguuaagaacaagaaauuagaacaagaaguuaccagaaaagugaaacuau
guaacugccucccaggauuacagagcugcauauccagaugauuugagccaagaaaucuacaucuc
uggguuccaauuucagugggaaaagaacaugcuugaggucuagaggaacgacugagaugccccag
ccuugugaagcagaagagaaaacaagcaaaccagcugcagaaaucuugauaaagccucaggaagag
aaaggagucucuggagagucugauguuagguguuugagguccagaaaaacuagagucgcuuugga
cauuugaaccuaagccaaggguaacucguggaaccaagaaagaugcaaaaacucugaaggaggau
gaagacagcaaagacauuuaagaaggaaaaguaaauuugacuuagugauaaguuccaguguggu
uuucaccuccaguguaaagaugaacuguaaauacuacgcuacugccugaguuuaaggaaggaagc
uuugagcuuuccuuugucauacucucuucagauccaauggaguuucaugaggaagaucaccaagg
aucucagcgcaauuacaguuuagggguaagcaggcagaaaugugacccucuguccuauccaauaa
agcucugaaauucgcugccaaaa
Cks2/CDC28 4 gacguagagccccuugcgcccgguuuccugaucccgcuuacuc 271
protein kinase cucugcgcgccggcaggauggcccacaagcagaucuacuacuc
regulatory agacaaguacuucgaugagcacuacgaguaccggcaugucaug
subunit 2, sim uuacccagagaacucucuaaacaaguacccaaaacucaucuga
to cdk uguccgaagaggaguggaggagacuugguguccaacagaguc
regulatory uaggauggguucauuacaugauucaugagccagaaccgcaua
subunit 2 uucuucucuuuagacgaccucuuccaaaagaacaacaaaaaug
AA681998 aagugcagcugggaucaucuaaucuuuucaaauuuaaugua
uauguguauuuaagguaguauucagugaauacuugaaaagug
uacaaaccuucauccauaccugugcaugcgcuguauucuuca
cagcaacagagcucagucaaaugcaacugcaaguagg
Ccng2/ 3 Sequence below. 272
Cyclin G2 cuacccuagacaaucacggcuuagccggcgcgcggagucgaucgucucggucgcuagagcugucc
U95826 ugagcucgaacgguccgacgcccccaccgcgccgguccgugacgccgggaccaacacgaugaagg
auuuuaggggccaagcacuuggcaggugacgaagggguucagcuuuucggauuguugaacuucuac
auggaggcuaccccggagaaugauaacacuuuguguucaagacugagaaaugccaaaguggaaga
uucuggaacaagaacagagauaccaaccucgggaaaaagggcugaucuuguaagaaguuuaacuaa
cuucuuuggaucuuggcacugaaacuuucguucuggcugucaauauuuuggauagauucuuggcc
cuuaugaagguaaaaccgaaacaccuguccugcauuggcgucugcugcuuuuugcuggccgccag
gcuggcggaagaagaaggugacguuccccccacgcacgacgugauccgcaucagucaguguaaaug
cacagcgucugacauuaaacgcauggagaaaaucaucucagagaaacugcacuaugagcuggaag
cuaccacugccuuaaacuuuuugcacuuguaccacgcgauuguauuuugucacacuucagaaagg
guuaaaaaacauuugaagcucagcgacacugaauucuuuuacuggagggaacugguuucuaaaug
ucaaggagauucucagccucgauaaacucgaagcgcagcugaaagcuugcaacugccgaguuguc
uucuccaaagcaagaccaucuguauuagcucugugccuucucaauuuggaaauagaaacgauaaa
aaucccguggaacugcuggaaauucucuugcuuuagcagaguauucuucgccucgcugcugcaag
ccugaucugaagaagcugguauggauuguuucgcgacgcacugcgcagaaccuccacagca
guacuacaguguuccugagcugcccacuaucccagagggggguugcuuugacggaagugaaagug
aggacucuggugaagcaugaguuguggagaggagagucucagcagcuccccacccagcgauca
ggagugcaccuucuucuuugacuuccaagaggcuucagacacuuguacuuuccaccauagagg
aaucugacauuguucuguaucagggaauuuauuaaguguguguaccuagguuucaaagcaauaaa
cuuggggguugaauaggguaguuuuccuagguuuccagccccccgucuagucagg
Prc 1/Protein 3 aacuaccuugagcagguuuuauuaacuugcaccuaacucagacg 273
regulator of ugaguaggacagaaggaagcugucccgggcgaacugagguca
cytokinesis 1 caaagacuugcuuuugauucaagagagaccuuaaaggcuagu
DNA segment, uaugauaguuaaguacaaguuuuaacaucugguagcuaacuu
Chr 7 uuuucucuaccccguaauucuacuaugacugcucuucuaga
AA856349 gguccugaguucaaaucccagcaaccacaugguggcucacaac
caucuauaaugggaucugaugcccucuucuggugugc
Thus, the transcripts identified in this Example, the proteins they encode, and the pathways in which the proteins participate, contribute significantly to induction of epidermal cells to differentiate into HF stem cells. Activation of the transcripts, proteins, and pathways depicted in Table 4 is thus a method for enhancing EDIHN. In addition, inhibition of the transcripts, proteins, and pathways depicted in Table 4 is thus a method for preventing EDIHN and eliminating hair follicles. In addition, inhibition of the transcripts, proteins, and pathways depicted in Table 5 is a method for enhancing EDIHN. In addition, activation of the transcripts, proteins, and pathways depicted in Table 5 is thus a method for enhancing EDIHN.
Example 10 Expression of Wnt-1 Inhibitors During the First Nine Days after Wounding Causes Pigmentation of New HF Materials and Experimental Methods In this Example, doubly transgenic mice expressing both tetO-Dkk1 and K5-rtTA were utilized. When these mice are fed chow formulated with 1 g/kg doxycycline (BioServ, Laurel, Md.), they express Dkk1, under the control of the K5 promoter, in the basal epidermis. The control mice also received doxycycline, but they were K5-rtTA negative and thus did not express Dkk1.
Results A 1 cm2 wound was induced on the lower back of the doubly transgenic mice at 21 days or 50 days old. Mice were placed on doxycycline-containing chow immediately after wounding to induce Dkk1 expression, and then doxycycline was discontinued after completion of the re-epithelialization at 9 days after wounding. Dkk1 expression inhibits Wnt activity, which in turn induces follicle pigmentation. At 22 days after wounding, pigmented HF were observed in the excised skin after preparing the epidermal sheet (FIG. 23A-B). Control mice lacked pigmented HF (FIG. 24).
In other experiments, continued expression of Dkk1 after the 9-day period inhibited formation of new HF.
The findings of this Example show that pigmented HF can be produced by suppressing expression of Wnt1 or by inducing expression of Dkk1 during the period of re-epithelialization, then inducing expression of Wnt1. In addition, the findings of this Example show that factors that inhibit neonatal hair follicle formation (e.g. Dkk1) also inhibit EDIHN, thus further supporting the notion that hair follicles formed by EDIHN are similar to normal hair follicles.
Example 11 Inhibition of EDIHN by Epidermal Growth Factor Injection 21 day-old mice were wounded as described in previous Examples. Starting from day 11 after wounding, a time point corresponding to the point at which the wound had recently re-epithelialized, 10 μL of 1 μg/ml EGF was injected into the wound bed. EGF was injected once per day after this point for a total of 5 days. Three days later, the skin was collected, and whole-mount EDIHN assays were performed. EGF prevented HF formation as assessed by gross morphology. In addition, whole mounts of control and treated skin were analyzed with anti-K17 antibody immunostaining. All mice injected with EGF (n=4) exhibited no new HF formation (FIGS. 25 A-B), while control mice (n=2) had many new HF, as expected. (FIGS. 25 C-D).
In an additional experiment, recombinant EGF (1 microgram (mcg)/microliter (mcl)) was injected at days 11, 13 and 15 after wounding. Skin was collected at 18 days after wounding and stained for K17 and alkaline phosphotase. Once again, administration of EGF inhibited EDIHN.
The findings of this Example show that EGF inhibits HF formation. Thus, inhibiting EGF, EGFR, or one of the pathways in which they participate increases EDIHN-induced HF formation.
Example 12 Enhancement of EDIHN by Inhibition of EGF Receptor To determine the effect of administration of EGF receptor inhibitors on DIHN, the inhibitor AG1478 (150 μM in 10 μL volume) was administered as a single injection 11 days after incisional wounding (1 cm2) to the middle of the wound near the skin surface. EGF receptor inhibitor administration led to generation of more and larger hair follicles compared with control mice that were wounded only (FIG. 26A). As shown in FIG. 26B, large hair follicles developed in the wounded area in the AG1478-injected mice. Left panel: epidermis stained for K17, with three large hair follicles next to each other. Right panel: dermis stained for AP with large coalescing dermal papilla areas.
The findings of this Example confirm the results of the previous Example, and show that more and larger HF can be generated when EDIHN comprises, or is followed by, administration of EGFR inhibitors, or with compounds with a similar mechanism of action; e.g. Hedgehog protein and androgen antagonists.
Example 13 Enhancement of EDIHN by Expression of a β-Catenin Activator To determine the effect of administration of β-catenin activators on EDIHN, K14-Wnt7 transgenic mice, which overexpress the β-catenin pathway activator, Wnt7, in the epidermis, were subjected to EDIHN, then HF formation was measured 19 days after wounding. In each of 2 separate experiments, with 4 week old and 3 week old mice, the transgenic mice developed significantly larger numbers of HF compared to control, non-transgenic littermate mice (FIG. 27 A-C).
Thus, administration of β-catenin activators leads to an increase in EDIHN. The findings of Examples 11-13 show that new HF can be generated by (a) disrupting the epidermis; and (b) administering a factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell.
Example 14 Enhancement of EDIHN by Administration of FGF To determine the effect of fibroblast growth factor (FGF) on EDIHN, recombinant FGF is administered 11 days after incisional wounding, as described in Example 11. FGF administration enhances HF formation, showing that new HF can be generated by (a) disrupting the epidermis; and (b) administering FGF, a nucleotide encoding FGF, or a factor that increases signaling by FGF.
Example 15 Enhancement of EDIHN by Administration of Edar To determine the effect of fibroblast growth factor (FGF) on EDIHN, K14-Eda-A1 transgenic mice, which overexpress (ectodysplasin-A1) Eda-A1 in the epidermis, are subjected to EDIHN, then HF formation is measured 19 days after wounding as described in Example 13. The transgenic mice develop significantly larger numbers of HF compared to control, non-transgenic littermate mice, showing that new HF can be generated by (a) disrupting the epidermis: and (b) administering a factor that enhances signaling by ectodysplasin.
Example 16 Enhancement of EDIHN by Administration of Minoxidil To determine the effect of minoxidil on EDIHN, recombinant FGF is administered 11 days after incisional wounding, as described in Example 11. Minoxidil administration enhances HF formation, showing that new HF can be generated by (a) disrupting the epidermis; and (b) administering a minoxidil.
Example 17 Removal of HF by Abrasion and Administration of EGF Hair-bearing regions of the epidermis of mice is abraded, as described in Example 1, then administering recombinant EGF, as described in Example 1. This method prevents hair re-growth in the abraded areas, showing that hair can be removed by (a) disrupting the epidermal layer; and (b) administering EGF, a nucleotide encoding EGF, or a factor that increases signaling by EGF.
