Treatment of contact lenses with an aqueous solution including sulfobetaine compounds

The present invention provides methods for treating contact lenses and compositions for the same. The present invention includes contacting a lens with an aqueous solution comprising a sulfobetaine compound represented by the formula: ##STR1## wherein: R.sub.1 is an alkyl group having from 8 to 30 carbon atoms, R.sub.2 and R.sub.3 are individually hydrogen or alkyl groups having from 1 to 4 carbon atoms, and R.sub.4 is an alkyl group having from 2 to 6 carbon atoms. In preferred embodiments of the invention, the subject compounds are used in combination with antimicrobial agents for providing simultaneous disinfection and cleaning of contact lenses.

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Claims

1. A method for treating contact lenses comprising contacting a lens with an aqueous solution comprising

(a) at least about 0.01 percent by weight of a sulfobetaine compound represented by the formula: ##STR5## wherein: R.sub.1 is an alkyl group having from 8 to 30 carbon atoms, R.sub.2 and R.sub.3 are individually hydrogen or an alkyl group having 1 to 4 carbon atoms, and R.sub.4 is an alkyl group having from 2 to 6 carbon atoms.

2. The method of claim 1 wherein R.sub.1 is an aliphatic alkyl group having from 8 to 22 carbon atoms.

3. The method of claim 1 wherein R.sub.1 is an aliphatic alkyl group having 10 carbon atoms.

4. The method of claim 1 wherein R.sub.2 and R.sub.3 are both methyl groups.

5. The method of claim 1 wherein R.sub.4 is an aliphatic alkyl group having 3 carbon atoms.

6. The method of claim 1 wherein the sulfobetaine compound comprises N-decyl-N,N-dimethyl-3-ammonio-1-propane-sulfonate.

7. The method of claim 1 wherein the solution further comprises an antimicrobial agent.

8. The method of claim 1 wherein the solution includes polyaminopropyl biguanide.

9. The method of claim 1 comprising the sequential steps of: rubbing the lens with the solution, followed by immersing the lens within the solution.

Referenced Cited
U.S. Patent Documents
4329335 May 11, 1982 Su et al.
4485029 November 27, 1984 Kato et al.
4622258 November 11, 1986 Mencke
4758595 July 19, 1988 Ogunbiyi et al.
5096607 March 17, 1992 Mowrey-McKee
Foreign Patent Documents
0736521 A1 October 1996 EPX
94/15649 July 1994 WOX
Other references
  • Meucci, V.P. et al "Solubilization Reagent for Biological Test Samples for Immunoassays" Chemical Abstracts, vol. 116 (1992) abstract No. 210753n. Rabilloud, T. et al "Amidosulfobetaines, a family of detergents with improved solubilization properties: application for isoelectric focusing under denaturing conditions" Chemical Abstracts, vol. 112, (1990) abstract No. 154543x. Toxicol. In Vitro (1995), 9(2), 185-90 Coden:Tivieq;ISSN: 0887-2333, 1995, XP000675837, Vivian, L. et al: "Comparision of Three In Vitro Cytotoxicity Assays for Estimating Surfactant Ocular Irritation" see column 2, line 12-column 2, line 30; tables 1,4.
Patent History
Patent number: 5765579
Type: Grant
Filed: Jan 30, 1997
Date of Patent: Jun 16, 1998
Inventors: David J. Heiler (Avon, NY), Suzanne F. Groemminger (Rochester, NY)
Primary Examiner: Jeffrey Snay
Attorney: Chris P. Konkol
Application Number: 8/795,048
Classifications