Disposable cartridge for investigating physical properties of blood
A disposable cartridge for measuring the physical properties of blood is disclosed. A waste compartment supports a platform having first and second syringe fittings. First and second syringes containing blood samples to be measured are positioned within the fittings. At least one testing station is located on the platform for subjecting blood flowing from one of the syringes to a test station, and the testing station is connected at a second end to the waste compartment. Tests on blood running through each of the blood channels may be conducted by inducing various platelet activation conditions, such as piercing a channel, or putting a platelet activating substance within a test channel. The cartridge interfaces with a test stand which will measure pressure changes within each of the test channels.
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Claims
2. The disposable cartridge of claim 1 wherein said second blood-carrying tube contains a platelet-induced body.
3. The disposable cartridge of claim 1 further comprising a vertically extending conduit connected to said fluidic couplings which is received in said syringes, and supplies said pressurizing fluid to said syringes.
4. The disposable cartridges of claim 3 wherein said guide means position said syringes to be tangential to a rear edge of said cartridge so that said syringes can be located against a common heating surface.
5. The disposable cartridge of claim 1 further comprising a tapered chamber having an axis aligned with said punching needle, said chamber tapered to receive an optical sensor for detecting blood exiting from a punched hole in said first blood-carrying tube.
6. The disposable cartridge of claim 5 wherein said tapered chamber includes an inlet for receiving a saline solution which washes blood from said hole punched in said first blood-carrying tube.
7. The disposable cartridge of claim 1 wherein each of said first and second blood-carrying tubes.Iadd.are supported.Iaddend.in a common plane to permit said tubes to be heated by a heating surface.
9. The apparatus of claim 8 wherein said test stand further comprises a second heater for maintaining said first and second testing channels at a constant temperature.
10. The apparatus of claim 9 further comprising an optical sensor support for maintaining an optical sensor positioned with respect to a bleeding chamber in one of said testing channels.
12. The apparatus of claim 8, wherein said test stand includes a source of pressurizing fluid coupled to said fluidic coupling inlets when said cartridge is received in said test stand.
13. The apparatus of claim 12, wherein said test stand includes first and second pressure transducers which measure the blood pressure in said first and second testing chambers.
15. A disposable cartridge according to claim 14, wherein said testing station comprises means for creating a precise opening in said conduit means to simulate bleeding.
18. The disposable cartridge of claim 14, wherein said test station further comprises a columnar pressure chamber having a volume of fluid immiscible with blood which is displaced by said blood, and which is connectable to a pressure transducer for monitoring pressure resulting from blood flowing into said columnar pressure chamber.
19. The disposable cartridge of claim 14 wherein said testing station includes means for introducing a shear force to blood flowing in said channel, thereby activating blood platelets.
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Type: Grant
Filed: May 30, 1996
Date of Patent: Jan 19, 1999
Assignee: XYLUM Corporation (Scarsdale, NY)
Inventors: Joseph Blake (New Canaan, CT), Robert P. Cousineau (Mt. Kisco, NY), Mark I. Rosen (Hackensack, NJ), William C. Watson (Greenwich, CT)
Primary Examiner: Jill Warden
Assistant Examiner: Sharidan Carrillo
Law Firm: Cushman Darby & Cushman Intellectual Property Group of Pillsbury Madison & Sutro, LLP
Application Number: 8/655,161
International Classification: G01N 1104;
