Abstract: A guide pin piercing jig includes a curved frame, a front cylinder unit provided at a front end of the frame, and a rear cylinder unit provided at a rear end of the frame, in which the front cylinder unit has a positioning projection and a boring aiming portion at a tip thereof, the rear cylinder unit has a plurality of parallel guide pin insertion cylinders into which to insert the guide pins and a tentative fixing unit provided at a tip of the rear cylinder unit, and the rear cylinder unit is provided at a rear end of the frame slidably so as be directed to a tip of the front cylinder unit. It becomes possible to aim at a proper portion of a living body bone through which to bore a bone tunnel and to pierce the living body bone with guide pins for hollow drills from behind the living body bone to the proper aiming portion in a proper direction.

Abstract: Ultrasound catheter devices and methods of the present invention generally provide for ablation and/or disruption of vascular occlusions. An ultrasound transmission member, such as a wire, transmits vibrational energy from an ultrasound transducer to a distal head of the catheter to disrupt vascular occlusions. An absorber member is disposed on or around the ultrasound transmission wire at a location adjacent the sonic connector of the catheter. The absorber member absorbs heat, vibrations, and/or the like from the ultrasound transmission wire at or near the area where the transmission wire is coupled with the sonic connector. The absorptive function typically slows the process of wear and tear on the transmission wire, thus extending the useful life of the ultrasound catheter.

Abstract: The present invention is directed to a method and apparatus for selective guide wire cannulation of a bile duct, removal of biliary calculi, and delivering hydrodynamic gene delivery are also provided. There is provided a method for straightening the terminal common bile duct to allow biliary calculi to be removed, assisting in creation of a gastoejunostomy, and selective guidewire cannulation. A method for isolating a segment of biliary epithelium for hydrodynamic gene delivery is also provided, in which a segment of the bile duct is isolated and plasmids (oncogenic or therapeutic) are injected under pressure to allow entry into cholangiocytes. There is also provided a method for isolating the cystic duct or left/right intrahepatic ducts to allow the insertion of a guide wire and subsequent therapy. A single catheter platform may be used to perform the above procedures.

Abstract: A surgical device includes an elongated shaft having an end-effector assembly at a distal end thereof. The end-effector assembly includes movable first, second and third jaw members. The first and second jaw members controllably movable from a first position, wherein the first and second jaw members are disposed in spaced relation relative to the third jaw member disposed therebetween, to a second position, wherein the first, second and third jaw members cooperate to grasp tissue therebetween.

Abstract: A surgical device adapter for coupling an end effector to a handle assembly is disclosed. The surgical device adapter includes: a housing including a proximal end couplable to a distal end of a handle assembly; and a drive coupling assembly selectively couplable to the handle assembly, the drive coupling assembly including a lock assembly having a pair of spring-loaded, opposing buttons movable from a clamped configuration in which the pair of opposing buttons are engaged to the distal end of the handle assembly to an unclamped configuration in which the pair of opposing buttons are disengaged from the distal end of the handle assembly.

Abstract: A surgical device for performing surgery includes a handle assembly, an elongate member extending from the handle assembly, an articulation mechanism, and an adapter. The elongate member has articulating and straight sections. The articulating section is configured to articulate with respect to the straight section. The adapter rotatably couples the elongate member with the articulation mechanism such that when the elongate member is in a first rotational orientation with respect to the articulation mechanism, the articulating section articulates toward a first direction relative to the straight section upon movement of the handle assembly towards the first direction with respect to the straight section and when the elongate member is in a second rotational orientation with respect to the articulation mechanism, the articulating section articulates toward a second direction relative to the straight section upon movement of the handle assembly towards the first direction with respect to the straight section.

Abstract: A surgical instrument includes a cutting member with an implement for cutting tissue, and a drive coupled to the cutting member to simultaneously rotate and translate the cutting member in response to a force applied to the drive. A method of cutting tissue includes positioning an outer member such that tissue is located within the outer member, engaging the tissue with an inner member, and simultaneously rotating and translating the inner member to cut the tissue. A tangential cutting force is applied to the tissue with the inner member to mechanically cut the tissue. The inner member is mechanically driven to undergo simultaneous rotation and translation.

Abstract: A surgical instrument includes a cutting member with an implement for cutting tissue, and a drive coupled to the cutting member to simultaneously rotate and translate the cutting member in response to a force applied to the drive. A method of cutting tissue includes positioning an outer member such that tissue is located within the outer member, engaging the tissue with an inner member, and simultaneously rotating and translating the inner member to cut the tissue. A tangential cutting force is applied to the tissue with the inner member to mechanically cut the tissue. The inner member is mechanically driven to undergo simultaneous rotation and translation.

Abstract: A surgical instrument includes a cutting member with an implement for cutting tissue, and a drive coupled to the cutting member to simultaneously rotate and translate the cutting member in response to a force applied to the drive. A method of cutting tissue includes positioning an outer member such that tissue is located within the outer member, engaging the tissue with an inner member, and simultaneously rotating and translating the inner member to cut the tissue. A tangential cutting force is applied to the tissue with the inner member to mechanically cut the tissue. The inner member is mechanically driven to undergo simultaneous rotation and translation.

Abstract: A surgical scalpel handle assembly system and method that requires a surgeon to actively perform a verification process known as a “time out” verification process but specifically requires sequentially moving a series of actuator knobs on a scalpel handle upon affirming each criterion embedded in the scalpel handle. The required sequential confirmation of each criterion unlocks and ejects a blade holder from a scalpel handle to a position fully engaged and ready for blade attachment, surgery and in cutting position. The assembly system and method includes exposed visual indicia on the handle that indicates red color in stand by pre-operative position and indicates green exposed visual indices upon affirming verification of “time out” criteria and thus triggering the deployment of a fully exposed, engaged, and in a ready for surgery for blade attachment in handle.

Abstract: Various medical devices and methods for cutting, evacuating and/or performing work on tissue are provided. The devices and methods may utilize a reciprocating mechanism or motor powered by suction from a vacuum source. The medical devices and methods may be used on tissue in various regions of a patient's body and for treating various conditions, e.g., for performing a polypectomy.

Abstract: A surgical device includes an elongated shaft having an end-effector assembly at a distal end thereof. The end-effector assembly includes first, second and third jaw members. The first and second jaw members controllably movable from a first position, wherein the first and second jaw members are disposed in spaced relation relative to the third jaw member disposed therebetween, to a second position, wherein the first, second and third jaw members cooperate to grasp tissue therebetween. The surgical device also includes a knife operatively coupled to the elongated shaft. A channel defined along a length of an upper surface of the third jaw member is configured to slideably receive a portion of the knife therein.

Abstract: An endoscopic surgical blade is disclosed. The blade is part of an endoscopic knife assembly which also has a knife tube and alignment ring. The endoscopic knife assembly is for use in endoscopic surgery by insertion of the assembly though a slotted cannula. The knife tube is hollow and allows the insertion of an endoscope for viewing of the surgical procedure. The blade has an upper and a lower cutting surface on the forward edge, which meet at an angle at a crotch.

Abstract: A tissue removal device is disclosed. In one arrangement, the tissue removal device comprises a cutting member operatively connected to an actuator assembly and a fixed member. The cutting member is configured to slide with respect to the fixed member in a reciprocating manner. The fixed member includes an upwardly extending foot plate that defines a contact surface that is configured with an uneven texture that serves as a grip to operatively retain material to be cut when the cutting member is moved toward the foot plate.

Abstract: A method of cutting tissue includes providing a surgical instrument including an end-effector assembly including first and second jaw members controllably movable from a first position in spaced relation relative to a third jaw member disposed therebetween to at least one second position closer to the third jaw member wherein the first, second and third jaw members cooperate to grasp tissue therebetween. Each of the first and second jaw members includes an electrically-conductive sealing plate. A cutting member is disposed on a portion of the upper surface of the third jaw member. The method also includes positioning the first, second and third jaw members about tissue, applying energy to the electrically-conductive sealing plates so that energy passes between the electrically-conductive sealing plates and through tissue to effect a tissue seal, and activating the cutting member to cut through tissue overlying the upper surface of the third jaw member.

Abstract: A tool and method for locating a proper position for a portal incision for hip arthroplasty, the tool being a tubular body having a first portion defining a first axis, a second portion defining a second axis non-parallel to the first axis, the second portion having a directional tool and a lead coaxially aligned, wherein when the tubular body is placed adjacent to an acetabulum with the directional tool aimed at the acetabulum and perpendicular to a plane of the face of the acetabulum, the lead points to location on the skin that would be the proper location for the portal incision. The lead may have a blunt tip, a cutting instrument, or an opening through which a flexible tool can be inserted to forge a path towards the proper location for the portal incision.

Abstract: A medical balloon assembly (10) includes a balloon (20) fitted to a balloon catheter (12). The balloon (20) includes a balloon wall (which is a co-extrusion) with ribs or strengthening elements (40) formed of the same polymer material, of a material of the same polymer type or of compatible polymer materials. The ribs in one embodiment extend into the thickness or depth of the balloon wall and in other embodiments may be flattened so as to present a substantially smooth outer surface to the balloon (20). The ribs (40) or strengthening elements may be made of or include radiopaque material.

Abstract: Described here are devices and components for use in performing an atherectomy. Generally, the atherectomy devices may have a handle, a cutter assembly, and a catheter or catheter assembly therebetween. The cutter assembly may include a housing and a cutter comprising a proximal cutter and a distal cutter, each of which may be rotated relative to the atherectomy device to cut occlusive material.

Abstract: An atherectomy device with an exchangeable drive shaft is disclosed, having a drive shaft gear at a distal end of the exchangeable drive shaft for meshing engagement with a prime mover gear on the output shaft of the prime mover. The exchangeable drive shaft is inserted into an opening at the distal end of the handle housing and moved axially in a proximal direction. Surface features on at least the prime mover housing and the engageable drive shaft help to align the drive shaft gear with the prime mover gear for meshing engagement.

Abstract: A capturing unit provided on a distal end of a second tube can be deformed into a contracted state and an expanded state, in which the capturing unit is deployed to form a capturing chamber. The capturing chamber has an opening area decreased as it goes from a distal end opening of the capturing chamber toward a proximal end opening of the capturing chamber. A third tube rotatable relative to the second tube and a cutting unit provided on a distal end of the third tube for cutting a foreign substance are arranged in a second lumen. In the expanded state of the capturing unit, the cutting unit is arranged more toward the proximal end opening of the capturing chamber than the distal end opening.

Abstract: An atherectomy catheter having an inner drive shaft which rotates a distal rotary tissue borer with a helical cutting surface which enables the catheter to cut through and cross a CTO. Additionally, the atherectomy catheter has a distal cutting element rotated by an outer drive shaft configured to cut material from the wall of a vessel at a treatment site as the catheter is pushed distally through the treatment site. The atherectomy catheter includes a collection chamber positioned proximally of the cutting element and rotary tissue borer. The atherectomy catheter may include means to direct material cut from the treatment site into the collection chamber, means to break down larger portions of material that may block or clog the collection chamber and means of transporting the material collected from the treatment site to a proximal opening in the atherectomy catheter.

Abstract: The puncture control system includes a trajectory error compensation filter for outputting a control signal for compensating for the error of a puncture needle from a target trajectory based on information on the position of the puncture needle obtained by a detector, a displacement compensation filter for which initial control parameters are determined based on a model representing characteristics of an organ, and an adder for outputting an added signal obtained by adding outputs of the trajectory error compensation filter and the displacement compensation filter. The organ model is used to predict a displacement of a puncture target position and sequentially determine a course of the puncture needle.

Abstract: A transseptal medical device is provided including a dilator, a needle, and a needle control mechanism. The needle may be disposed within the dilator, and the needle control mechanism may be operably connected to a proximal end of the needle or the dilator for selective adjustment of the distal end of the needle from a first position within the dilator to a second position external to the dilator. The needle control mechanism may include an actuator configured for rotation within the dilator in one embodiment. In another embodiment, the proximal end of the dilator may incorporate internal threads and the proximal end of the needle may incorporate external threads, such that the needle may be configured for rotation during selective adjustment of the distal end of the needle from a first position to a second position. A method for puncturing a septum of a heart is also disclosed.

Abstract: A surgical tool set for treating a collapsed lung condition employs a trocar (20), and a nested cannula including a pleural port tube (30) and a fluid suction tube (50). In operation, the trocar (20) is nested within the pleural port tube (30), and utilized to puncture a port into a pleural cavity (10) of the patient while securing the pleural port tube (30) within the port. Subsequent to removing the trocar (20) from the pleural port tube (30), a fluid suction tube (50) is advanced with a fixed orientation through the secured pleural port tube (30) in a direction of a pleural cavity (10) target location (15) and air is suctioned from the pleural air space through one or more perforated holes into the fluid suction tube (50). The fluid suction tube (50) may have a target orientation section (42) or an additional target orientation tube (40) may be used to fix the orientation of the fluid suction tube (50) relative to the pleural port tube (30).

Abstract: Cannula assemblies and methods of conducting surgeries. The cannula assembly comprises a cannula that is sized for the common 4 mm arthroscopy switching stick, which is put in a one-step fashion with the use of a unique switching stick inserter. All steps for placement of the cannula are performed in a single forward motion, i.e., no backing up of components are necessary for placement. The method of conducting surgery includes the steps of: providing a cannula/switching stick assembly comprising a cannula sized to accommodate a corresponding switching stick, and a switching stick inserter (modular handle) designed to fit on the switching stick, and to help insert and control the switching stick; and inserting the cannula/switching stick assembly through an arthroscopic portal during a surgical procedure, in a single forward motion.

Abstract: Provided herein are trans-abdominal gastric systems and related methods that are useful in a range of applications for accessing internal regions of a patient. A cannula has internal and external anchors to reliably secure the anchor to an abdominal wall of the patient. An introducer with a capture element facilitates system placement by retrograde introduction. Upon completion, the system is removed and the gastric and abdominal wall incision and defect closed by sutures specially connected to the system that ensures reliable system removal and suture closure in a configuration that is outside the abdominal wall. The systems and methods are particularly suited for use with conventional laparoscopic or endoscopic medical instruments.

Abstract: A surgical apparatus includes a housing member and an inner member. The housing member includes an expandable material that is adapted to transition between a compressed condition and an expanded condition. In the expanded condition, an outer surface of the housing member is adapted for a substantial sealing relationship with tissue upon insertion of the housing member within the tissue for accessing an underlying tissue site. The housing member has leading and trailing ends that define a longitudinal axis. The inner member is operably associated with the housing member and includes one or more longitudinal portals extending therethrough adapted for substantially sealed reception of a surgical object. The inner member may be less compliant than the housing member. The inner member may rotate about the longitudinal axis of the housing member.

Abstract: An access assembly configured to receive one or more surgical instruments is provided. The access assembly includes a flexible housing having a proximal end and a distal end, the housing defining a longitudinal passageway extending from the proximal end to the distal end and a seal assembly received within the longitudinal passageway of the housing. The seal assembly defining a plurality of ports each configured to receive an instrument inserted therethrough in a sealing manner.

Abstract: A dilator that facilitates implantation of an interspinous spacer is provided. The dilator includes a proximal portion and a tapered distal portion interconnected by an elongated body portion. The tapered distal portion is ideally suited for splitting ligamentous tissue for creating a posterior midline pathway through the supraspinous ligament as well as for distracting the adjacent spinous processes. Two oppositely located and longitudinally extending channels or grooves are formed in the outer surface of the dilator for stabilizing the dilator with respect to the spinous processes. An accompanying cannula together with the dilator form a system for the distraction of the adjacent spinous processes, stabilization of the spinous processes with respect to the system and creation of a working channel for the implantation of an interspinous spacer.

Abstract: A beauty tool (1) includes: a substantially rod-shaped main body (10); an attraction head (2) provided in the main body (10); and a beauty effect imparting part for imparting a beauty effect to human skin in a state where it is in contact with or close to the human skin. The attraction head (2) is provided at one end of the main body (10) and includes a magnetic force generating surface (20) for attracting and removing, by means of a magnetic force, a cosmetic agent applied to the human skin.

Abstract: Orthopaedic device (10, 110, 210, 310) for correcting deformities of a long bone (11), comprising a bar (12), extended along an axis (Y-Y) and intended to be placed alongside the bone (11), at least a first clamp (14, 214, 314) for a first group of osseous screws (16) and a second clamp (18, 19, 118) for a second group of osseous screws (20, 22), removably mounted on said bar (12), wherein the first of said clamps (14, 214, 314) is placed onboard a support base (21, 221, 321) in turn mounted on said bar (12), and angularly movable in relation to the support base around a given rotation axis (X-X, X?-X?, Z-Z) by means of a rotary coupling, characterised in that said rotary coupling comprises a male element (35; 235, 236, 237, 238, 239; 333, 334) associated with the first clamp (14, 214, 314) and having a surface at least partially cylindrical, and a corresponding female element (36; 130; 250, 254, 255; 336, 337) associated with the support base (21, 221, 321) and having a surface at least partially cylindrical

Abstract: The invention relates to an apparatus for displacing tissue within the body, wherein the apparatus includes two or more attachment members selectively displaceable with respect to each other via a driving member. The driving member preferably is rotatable and is caused to rotate by a magnetic actuator that can be activated by a magnetic field from outside the body.

Abstract: An assembly is disclosed for treating an isthmic fracture. It also relates to an assembly which includes materials and instruments for utilizing the assembly in connection with treating the fracture.

Abstract: The present method includes the following steps: removing a portion of a previously implanted spinal arthroplasty device; and attaching a revision component to a remaining portion of the previously implanted spinal arthroplasty device to alter a biomechanical characteristic of the implanted arthroplasty device. Another aspect of the invention provides a method of limiting motion between adjacent vertebrae including the steps of accessing an implanted spinal arthroplasty device comprising a cephalad component fixed to a first vertebra and a caudal component fixed to a second vertebra inferior to the first vertebra, the cephalad and caudal components having a range of motion between them, and attaching a revision component to the cephalad and caudal components to reduce the range of motion. The invention also includes revision devices for revising the biomechanics of implanted spinal arthroplasty devices.

Abstract: Devices, systems and methods for dynamically stabilizing the spine are provided. The devices include an expandable spacer or member having an unexpanded configuration and an expanded configuration, wherein the expandable member in an expanded configuration has a size, volume and/or shape configured for positioning between the spinous processes of adjacent vertebrae in order to distract the vertebrae relative to each other. The systems include one or more expandable members and an expansion medium for injection within or for filling the interior of the expandable member via the port. The methods involve the implantation of one or more devices or expandable spacers.

Abstract: A method and device for inserting screws into a patient, such that when the device is removed the device does not stick to the screw. The device, being a push-off driver, may have a handle, an inner driver, and a threaded driver sleeve having a button mechanism and a plurality of spheres, and an inner sleeve. The method includes the steps of assembling a push-off driver attaching a bone screw to the push-off driver inserting the bone screw and detaching the bone screw from the driver by unthreading the threaded driver sleeve from the polyaxial screw which causes the spheres in the recess of the inner driver to back up against the start of the recess and causing the threaded driver sleeve to “push-off” the polyaxial screw from the inner driver.

Abstract: A tool set for implanting a rod in a human spine in conjunction with bone screws. The tool set includes a pair of end guide tools that receive opposite ends of the rod in channels and under manipulation by a surgeon facilitate transport of the rod toward the bone screws attached to the guide tools. Intermediate guide tools having guiding pass through slots are utilized to guide intermediate locations along the rod toward associated bone screws. An attachment structure operably connects the guide tools to the bone screws. The guide tools each include a lower guide and advancement structure to allow a closure top with mating structure to be rotated and driven downward against the rod and to cooperate with similar structure in the bone screw to seat and lock the rod therein. A method utilizing the tool set allows a surgeon to percutaneously implant the rod in the patient.

Abstract: A pin made of cortical bone may be inserted into adjoining bones of a toe to align and secure the bones. The pin may have barbs to prevent migration of the pin. The pin may include a shoulder to further prevent migration of the pin from the bones, to increase the strength of the pin, and to increase the surface area between the bone pin and the host bone. The pin may further include flattened portions on its circumference to aide in rotating the pin during insertion. The pin may be treated to reduce brittleness.

Abstract: The invention comprises a method for fixating bones in the foot by aligning the bones in their desired position, inserting a screw in the aligned bones, inserting at least one transverse element near the head or tip of the screw, and tightening the screw to compress the bones. The screw comprises a shaft having first and second ends with spirally wound screw threads beginning near the first end and extending along the shaft. Advantageously, the screw is cannulated and screw threads are formed on an interior surface of the cannulation. Illustratively, the transverse elements may be staples, open-ended washers, or open-ended nuts. Reduction instruments and drill guides used in the invention are also disclosed.

Abstract: A bone plate system having a retainer for resisting back-out of a bone anchor from a throughbore of a bone plate is provided. In one aspect, a bone plate system having a resilient retainer disposed in a bone plate throughbore with a pair of elongate arm portions of the resilient retainer extending along opposite sides of the throughbore. In another aspect, a bone plate system having a resilient retainer with a pair of elongate interference portions completely exposed in the throughbore and spaced from each other across the throughbore to retain a head of a bone anchor received in the throughbore. In addition, a bone plate system having a resilient retainer with a pair of opposite end portions disposed within a groove of a throughbore wall such that a bone anchor may be inserted into the throughbore without contacting either of the opposite end portions of the retainer.

Abstract: The self-locking osteosynthesis device includes a plate equipped with holes for the passage of fixation screws. The invention is characterized in that, at least in the areas defining the screw holes, the aforementioned plate is made from a material having mechanical properties such that the periphery of the holes can be self-tapped by means of tapping screws which can be used to fix the plate.

Abstract: A medical apparatus including a bar with a first attachment loop, a second attachment and a plurality of hooks, wherein the medical apparatus is an arch bar.

Abstract: Expandable fixation assemblies, expandable cranial fixation assemblies, and expandable intervertebral implant assemblies are provided for securing structures to bone and for securing bones and/or bone segments with respect to each other. An expansion member can be moved through at least a portion of an expandable fixation body, thereby causing expansion of the expandable fixation body, such that bone engagement features of the expandable fixation body engage surrounding structure, such as bone.

Abstract: The invention concerns an osteosynthesis screw (1) formed from a core (2) externally provided with a helical thread (3), said screw comprising a distal penetration portion and a proximal portion forming the head of the screw (6) and having a conical longitudinal section characterised in that the proximal portion comprises annular notches which are formed in the thickness of the core (2) and in the gaps between the threads of said proximal portion in such a way as to reduce the radial pressure during screwing.—Surgical device.

Abstract: A bionic apparatus is provided. The bionic apparatus includes a flexible portion having a plurality of pores, a rigid portion connected with the flexible portion, and a supporting element disposed in the flexible portion. The pore size of each pore is between 50 ?m to 500 ?m. The flexible portion, the rigid portion and the supporting element are one-piece formed by a additive manufacturing process.

Abstract: A bone screw arrangement with a variable length, comprises a guide screw, which is formed with a guide that extends in the axial direction in the interior of the guide screw, and comprises an anchor screw, which has a guide element that is received in the guide such that an arrangement length formed by the guide screw together with the anchor screw can be adjusted by moving the guide element in the axial direction in the guide in the interior of the guide screw. The guide element is received in a free-running manner in a portion of the guide when the guide element is moved in order to change the arrangement length, and the guide element is blocked from running freely in the axial direction at least in a distal end position in which the anchor screw is completely extended.

Abstract: The embodiments provide devices and methods that both strengthen the bone and stimulate the bone. Bone fractures or non-unions are stabilized, integrated or healed, which results in reduction of a bone defect, such as a bone marrow lesion or edema. In addition, the distribution of forces in a joint are restored or altered to relieve pain. In general, a joint is evaluated by taking an image of the joint and one or more subchondral defects are detected. At least one of the subchondral defects may be diagnosed as the source of pain and an extent of treatment for the subchondral defect is determined. The disclosed devices and techniques are particularly suited for treating chronic defects or injuries, where the patient's natural healing response has not resolved the defect. The present disclosure also provides several exemplary treatment modalities for the different extents of treatment needed.

Abstract: Various embodiments of the present disclosure include a tool for stabilizing a fractured bone. The tool comprises a barrel having a proximal end and a distal end. The distal end of the barrel includes a passageway for receiving a bone pin configured to be driven into the fractured bone to stabilize the fractured bone. The passageway is sized to accommodate axial movement of the bone pin through the passageway while limiting radial movement of the bone pin in the passageway. The tool further comprises a piston having a proximal end and a distal end and configured to translate axially relative to the barrel. The proximal end of the piston includes a head and the distal end of the piston includes a needle formation, the needle formation being sized for receipt within the passageway of the barrel to drive the bone pin axially from the barrel and into the fractured bone.

Abstract: A method of non-thermally ablating undesirable tissue in the body by application of pulsed, bi-polar, instant charge reversal electrical fields of sufficient energy to cause complete and immediate cell membrane rupture and destruction. Energy is delivered through radio frequency pulses of particular frequencies, wave characteristics, pulse widths and pulse numbers, such that enhanced physical stresses are placed on the cell membrane to cause its immediate and complete destruction thereby spilling the entire cell content and membrane constituents into the extracellular space without denaturing proteins so as to enable animmunological response to destroy and remove the target tissue and similarly marked tissue elsewhere in the subject.

Abstract: A device for effecting change in tissue at a treatment site includes a housing having an aperture for receiving a user's finger, a cold plate supported by said housing for cooling the tissue at the treatment site, and at least one thermoelectric cooling semiconductor thermally coupled to said cold plate and electrically coupled to a power source. In another embodiment, the cold plate may include a surface for contacting the treatment site, and at least a portion of said cold plate including said surface may extend from said housing.