Abstract: In accordance with embodiments of the present disclosure, a ballistocardiogram (BCG) sensor is used to detect heart and vascular characteristics of a user, and provide a BCG output indicative of the detected cardiovascular characteristics. The BCG output can be used for various purposes, such as detecting arterial aging. Secondary sensors can be used in conjunction with the BCG and can be used to determine the central arterial blood pressure, when used in conjunction with a peripheral blood pressure measurement.

Abstract: Aspects of the present disclosure relate to systems and methods for medical imaging that incorporate prior knowledge. Some aspects relate to incorporating prior knowledge using a non-local means filter. Some aspects relate to incorporating prior knowledge for improved perfusion imaging, such as those incorporating arterial spin labeling.

Abstract: A method includes, in a living organ (28) in which an ambient pressure varies as a function of time, sensing the ambient pressure using a pressure sensor (36, 90, 174), which has a capacitance that varies in response to the ambient pressure, so as to produce a time-varying waveform. A calibration voltage, which modifies the capacitance and thus the time-varying waveform, is applied to the pressure sensor. The time-varying waveform is processed so as to isolate and measure a contribution of the calibration voltage to the waveform. A dependence of the capacitance on the ambient pressure is calibrated using the measured contribution of the calibration voltage.

Abstract: Embodiments of the present disclosure relate to a system and method for determining a physiologic parameter of a patient. Specifically, embodiments provided herein include blood pressure cuffs that are adapted to be used in conjunction with a photoplethysmography sensor. The cuff as provided may be configured to be placed over the sensor and/or aligned in a specific manner relative to the sensor. Alternatively, the cuffs may include integral optical components.

Abstract: The invention relates to a method for determining the physical and/or psychological state of a subject. The heart rate variability (HRV) of the subject is analyzed in the time domain, wherein at least one frequency distribution of interbeat intervals (IBI) which are detected in at least one examination time period (1) is examined in the analysis. In order to obtain particularly significant and quickly interpretable information for this purpose, the frequency distribution is examined for a multimodal distribution.

Abstract: For easy determination of the current stress condition of a person, a device is proposed that detects the pulse rate and therefrom additionally determines the heart rate variability. In addition, at least one parameter related to the history of one of the two above mentioned values shall be used. Preferably, the deviation of the cardiac frequency and of the heart rate variability from a reference value is integrated and used as an additional stress indicator.

Abstract: In illustrative implementations of this invention, a photoplethysmographic device measures variations of light that is reflected from, or transmitted through, human skin. In some implementations, the device includes a camera that takes the measurements remotely. In others, the device touches the skin during the measurements. The device includes a camera or other light sensor, which includes at least orange, green and cyan color channels. In some cases, such as a contact device, the device includes three or more colors of active light sources, including at least orange, green and cyan light sources. A computer analyzes the sensor data, in order to estimate a cardiac blood volume pulse wave. For each cardiac pulse, a computer detects the systolic peak and diastolic inflection of the wave, by calculating a second derivative of the wave. From the estimated wave, a computer estimates heart rate, heart rate variability and respiration rate.

Abstract: A method for controlling electrical conditions of tissue in relation to a current stimulus. A first current produced by a first current source is delivered to the tissue via a current injection electrode. A second current drawn by a second current source is extracted from the tissue via a current extraction electrode. The second current source is matched with the first current source so as to balance the first current and the second current. A ground electrode which is proximal to the current injection electrode and the current extraction electrode is grounded, to provide a ground path for any mismatch current between the first current and second current. A response of the tissue to the current stimulus is measured via at least one measurement electrode.

Abstract: A system for electrocardiogram (ECG) interpretation includes a processor and memory coupled to the processor. A rendering module is stored in the memory and is configured to receive input from an ECG and correlate interpretation statements with ECG measurements responsible for the interpretation statements in the ECG. An interface is configured to permit user selection of at least one interpretation statement in a display, the display being configured to render visual indications of the ECG measurements on digitally rendered waveforms of the ECG.

Abstract: A system can include a near-field instrument to be placed inside a chamber of a heart, a far-field instrument to be placed in a stable position in relation to the heart, and a control unit. The control unit is configured to identify a unique pattern in electrogram information received from the far-field instrument when the near-field instrument is in one or more positions within the heart. When the unique pattern is detected, the control unit is configured to receive electrogram information from the near-field instrument. While recording electrogram information from the near-field instrument, the control unit is also configured to record voltage and complex fractionated atrial electrogram (CFAE) characteristics of the tissue inside a heart chamber. This information combined with rotor information can be used to identify substrate versus non-substrate rotor characteristics.

Abstract: An implantable system includes terminals, a pulse generator, a sensing circuit, separate signal processing channels, and first, second and third multiplexers. The terminals are connected to electrodes via conductors of leads. Different subsets of the electrodes are used to define different electrical pulse delivery vectors, and different subsets of the electrodes are used to define different sensing vectors. The pulse generator produces electrical pulses, and the sensing circuit senses a signal indicative of an impedance associated with a selected sensing vector. The first multiplexer selectively connects outputs of the pulse generator to a selected one of the different electrical pulse delivery vectors at a time. The second multiplexer selectively connect inputs of the sensing circuit to a selected one of the different sensing vectors at a time. The third multiplexer selectively connects an output of the sensing circuit to one of the plurality of separate signal processing channels at a time.

Abstract: This invention relates to the determination and/or representation of physiological information relating to a heart surface.

Abstract: Example devices are disclosed herein that include a first elongated band coupled to a first housing to be located on a first side of a head of a subject and a second housing to be located near a second side of the head of the subject, the first elongated band comprising a first set of electrodes. The example device also includes a second elongated band coupled to the first housing and to the second housing, the second elongated band comprising a second set of electrodes. In addition, the device includes a third elongated band coupled to the first housing and to the second housing, the third elongated band comprising a third set of electrodes.

Abstract: An EEG monitor with sensors placed to detect signals and analyze the signals to determine if a frequency below 12 Hz, and more particularly between 3 Hz and 8 Hz, called theta waves, are present. Theta waves are generated when the brain is entering a drowsy or sleep mode. The sensors detect brain wave signals and transmit the signals to a microprocessor which analyzes the signals and determines the brain waves being detected. The brain waves are continuously monitored and the data is continuously transmitted to a microprocessor. If brain waves are detected in the predetermined range of between 3 Hz and 8 Hz the microprocessor activates a stimulus, to wake up the person wearing the device. The stimulus may be visual, auditory or tactile, such as an actuator, a phone call or any other stimulus.

Abstract: Concepts presented herein include an apparatus for monitoring EMG signals of a patient's laryngeal muscles. The apparatus includes an endobronchial tube having an exterior surface and two lumens for providing ventilation. Conductive ink electrodes are formed on the exterior surface of the endobronchial tube. The conductive ink electrodes are configured to receive the EMG signals from the laryngeal muscles when the endotracheal tube is placed in a trachea of the patient. At least one conductor is coupled to the conductive ink electrodes and is configured to carry the EMG signals received by the conductive ink electrodes to a processing apparatus.

Abstract: Aspects of the present disclosure relate to magnetic resonance thermometry. In one embodiment, a method includes acquiring undersampled magnetic resonance data associated with an area of interest of a subject receiving focused ultrasound treatment, and reconstructing images corresponding to the area of interest based on the acquired magnetic resonance data, where the reconstructing uses Kalman filtering.

Abstract: A system and method for locating a medical device within a body uses wireless technology to transmit the information obtained from the sensors to a mobile device or other computing system. A software application on the mobile device or computing system can be used to display the information, wherein the user can control the display without needing to contact any items that are not sterile.

Abstract: A device and method for a surgical navigation system comprising a connection unit, a marker carrier unit removably attached to the connection unit, an attachment unit connected to the connection unit for fixing the device to a body part of a patient. The connection unit comprises an articulated arm and the marker carrier unit comprises an attachment area for removably attaching the marker carrier element to the connection unit.

Abstract: A device and manufacturing method for a surgical navigation system, comprising a frame member having an attachment location and a rigid mounting device disposed in the attachment location. The frame member comprises an upper straight portion connected to a lower straight portion via a bent portion, wherein the lower straight portion comprises a plurality of mounts each having a top surface. A centerline extending through the rigid mounting device is level with each of the top surfaces.

Abstract: Apparatus and methods are described for use with an endoluminal data-acquisition device having a radiopaque portion coupled thereto, including, while the endoluminal data-acquisition device is being moved through the lumen, acquiring a plurality of endoluminal data points of the lumen using the endoluminal data-acquisition device. A combined extraluminal image of the lumen is generated that contains images of the radiopaque portion at first and second locations within the lumen, by co-registering first and second extraluminal images with each other. At least one location on the combined extraluminal image is identified as corresponding to a location within the lumen at which a given one of the endoluminal data points was acquired, by identifying the first and second locations of the radiopaque portion within the combined extraluminal image. An output is generated, in response thereto. Other applications are also described.

Abstract: Disclosed herein, among other things, are methods and apparatus related to identification of apnea type. One aspect of the present subject matter provides a method for real-time apnea discrimination. The method includes sensing an impedance-based tidal volume signal to monitor a respiratory cycle of a patient, and detecting a reduction in tidal swing using the sensed impendence to detect an apnea event. When the apnea event is detected, a shape of the sensed signal is compared to a stored signal shape to determine whether the apnea event is primarily an obstructive sleep apnea (OSA) event or primarily a central sleep apnea (CSA) event, in various embodiments.

Abstract: A biological information acquisition apparatus includes a light source, a light-receiving unit, and a calculation unit. The light source is configured to irradiate a biological body with light. The light-receiving unit is configured to receive the light from the biological body. The calculation unit is configured to determine biological information. The calculation unit is configured to detect a first value by using a first signal from the light-receiving unit while the light source emits the light, detect a second value by using a second signal from the light-receiving unit while the light source does not emit the light, determine a temperature of the biological body based on the second value, and correct the first value using the temperature.

Abstract: An optical isolation element is provided on an optical sensor comprising a light source, at least one photodetector, and indicator material that emits light that is detected by the photodetector when optically excited by the light source. The optical isolation element limits the optical paths by which light may be transmitted by the light source, thereby limiting exposure of the excitation light source to regions of interest. The optical isolation element also limits the optical paths by which light may be transmitted to the photodetector, thereby limiting exposure of the photodetector to light from extraneous sources.

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Abstract: Methods and apparatus for providing data processing and control for use in a medical communication system are provided.

Abstract: An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. The working electrode can have a first side edge and a second side edge. The reference electrode can be situated such that at least a portion of the first and second side edges of the working electrode are adjacent respective sections of the reference electrode.

Abstract: Disclosed are methods, apparatuses, etc. for calibrating glucose monitoring sensors and/or insulin delivery systems. In certain example embodiments, blood glucose reference samples may be correlated with sensor measurements with regard to a delay associated with the sensor measurements. In certain other example embodiments, a blood-glucose concentration in a patient may be determined based, at least in part, on one or more probability models, one or more functions for estimating blood-glucose concentrations, and/or blood glucose reference sample-sensor measurement pairs.

Abstract: A measuring device for an analyte in a specimen includes a device body, and a sensing unit and an installation unit that are disposed on the device body. The sensing unit includes a measuring module to measure a parameter of the analyte in the specimen. The installation unit removably installs the device body on a drug injection device.

Abstract: A system and method for separating a venous component and an arterial component from a red signal and an infrared signal of a PPG sensor is provided. The method uses the second order statistics of venous and arterial signals to separate the venous and arterial signals. After reliable separation of the venous and the arterial component signals, the component signals can be used for different purposes. In a preferred embodiment, the respiratory signal, pattern, and rate are extracted from the separated venous component and a reliable “ratio of ratios” is extracted for SpO2 using only the arterial component of the PPG signals. The disclosed embodiments enable real-time continuous monitoring of respiration pattern/rate and site-independent arterial oxygen saturation.

Abstract: A catheter system and related method for measuring the oxidation state of biological molecules in a region of a measurement site of a subject. The system may include a catheter device having one or more emitters in mechanical communication with the catheter and configured to make contact with a tissue wall of the subject. The catheter device also includes one or more detectors in mechanical communication with the catheter and configured to make contact with the tissue wall of the subject. The emitters and the detector are in electromagnetic radiation communication with one another, whereby the electromagnetic radiation communication allows visible radiation or near infrared radiation emitted by emitters to be detected by the detector to determine tissue oxidation state of the region of the measurement site of the subject.

Abstract: A biological information measurement device according to the present invention detects a signal expressing biological information from a fingertip using an internal sensor (S1). A first perfusion index and first biological information aside from the first perfusion index are obtained from the signal detected by the internal sensor (S2, S3). It is determined whether or not the first perfusion index is greater than or equal to a first threshold (S4). When the first perfusion index is greater than or equal to the first threshold, the first biological information is permitted to be displayed in a display unit (S5). However, when the first perfusion index is less than the first threshold, a notification is made indicating that an external sensor that is lighter than a main body, is an entity separate from the main body, and is communicably connected to the main body is to be used (S6).

Abstract: Apparatus, systems, and methods are provided that generate in vivo maps of oxygenation measurements of biological tissue. These may include surgical instruments and stand-alone imaging systems with incorporated oxygen sensing capability. Oxygenation maps can be determined via fluorescent or phosphorescent lifetime imaging of an injectable probe with an oxygen-dependent optical response. Probe configuration and methods and apparatus of injecting the probe into the tissue are provided. Methods and apparatus for temperature compensation of temperature-dependent lifetime measurements are provided to improve oxygenation measurement accuracy. Oxygen maps may be registered with visible light images to assist in assessing tissue viability or localize anomalies in the tissue.

Abstract: Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.

Abstract: Provided are sensor systems and methods for detecting analytes of bodily fluids. The systems can be used to reduce the administration volume of certain compounds and/or fluids during medical monitoring or other procedures by providing a calibration path configured to receive a first fluid, a sample path isolated from the calibration path, the sample path configured to receive a bodily fluid from a subject, and a sensor apparatus comprising at least one sensor selectively positionable between the calibration path and the sample path.

Abstract: A game board and method for diagnosing and treating neurological disorders such as attention deficits and/or comorbidities, attention deficit hyperactivity disorder, and/or conditions with attentional impairment such as autism spectrum disorder (ASD), anxiety, depression, and epilepsy The game board has two sets of marks, each set forming a line, wherein a first line is orientated in a first direction parallel with a side of the rectangular game board, and a second line orientated in a second direction diagonal to the first line. Objective cubes are variously positioned on the marks and the player is instructed to hit an objective cube according to whether it displays a particular image. Distractors are employed to assist in diagnosing and treating the disorder.

Abstract: A pressure sensing catheter system includes a urethral catheter and a sensor array formed on the urethral catheter. The sensor array includes a plurality of pressure sensors distributed along a length of the urethral catheter. The sensor array is configured to produce a dynamic pressure distribution profile along a urethra.

Abstract: Disclosed herein are apparatus and methods for delivering bone conduction stimuli for measuring the gravitation receptor functions of the inner ear. In some embodiments, a system may include (i) an impactor operatively linked to a guide disposed within a housing and (ii) an electrically driven actuator enclosed within the housing. The electrically driven actuator may be configured to cause the impactor to (i) travel to a striking point to deliver a mechanical bone conduction stimulus for transmission to a skull bone and (ii) controllably decelerate prior to the instance of stimuli delivery. The system may also include an oculometric response monitoring system including a video camera for capturing video of motion of one or more eyes of the patient.

Abstract: The system and method for detecting seizure activity combines signal traces from both an electroencephalogram (EEG) and an electrocardiogram (ECG) in order to detect and predict a seizure event in a patient. Determination of a seizure classification of the combination is based on Dempster-Shafer Theory (DST) to calculate a combined probability belief. Prior to combination, classification of the EEG and ECG data is performed by linear discriminant analysis (LDA) or naïve Bayesian classification to provide a seizure event classification or a non-seizure event classification.

Abstract: A method and apparatus for diagnosing a user's health state are provided. The apparatus includes including a voice detecting unit which detects and monitors a user's voice; a voice analyzing unit which extracts a voice feature from a voice detected by the voice detecting unit, based on a health state to be diagnosed; a voice diagnosing unit which diagnoses a health state of the user by comparing the voice feature extracted by the voice analyzing unit with an abnormal state reference, and which monitors a change in the health state; and a diagnosis outputting unit which outputs information regarding the health state and a health state change diagnosed by the voice diagnosing unit.

Abstract: Methods, devices and systems to detect analyte level in a patient with gestational diabetes and/or provide related therapy management are provided.

Abstract: An apparatus may be configured for documenting a code blue scenario when adhered to the chest of a subject undergoing resuscitation by sensing and transmitting information associated with the code blue scenario. Such information may include one or more of vital signs of the subject during resuscitation, information associated with chest movements of the subject during resuscitation, and audio information from an environment of the subject during resuscitation. A computing platform that is separate and distinct from the apparatus may provide code blue documentation conveying information related to the vital signs of the subject and derived from the audio information from the environment of the subject during resuscitation.

Abstract: A method of measuring signals for a wearable electronic device includes setting at least one threshold value corresponding to each of a plurality of physiological signals of a user; measuring the plurality of physiological signals to obtain a plurality of measurement data; and obtaining a measurement result according to the threshold value and the plurality of measurement data.

Abstract: Example headsets and methods for gathering electroencephalographic signals are disclosed herein. An example headset includes an adjustment assembly including a first support to be disposed on a first side of a head of a person and a second support to be disposed on a second side of the head of the person. The example headset also includes an adjustor operatively coupled to the first support. Further, the example headset includes an electrode strip and a tension strap having a first end operatively coupled to the adjustor and a second end operatively coupled to the second support.

Abstract: The invention relates to a slash and gash resistant protective composite fabric comprising at least one layer of base fabric, wherein the base fabric is a densely woven, ballistic fabric. At least one layer of rigid fabric, each having a base layer and a hard polymer layer having a special matrix, is bonded onto the base layer, and the rigid fabric is cut into strips of material having a scale-like pattern or shape. Each of the strips of material are connected to the layer of base fabric in overlapping layers whereby the base fabric is covered. The protective composite fabric further includes a resilient elastically deformable material having at least one sensor therein for monitoring of vital signs of a wearer, the resilient elastically deformable material being connected with the at least one layer of a base fabric and the rigid fabric.

Abstract: The invention relates to a device and a method for noninvasive measurement of parameters of a bodily tissue, the measuring device having a sensor unit and a sensor mat for detachable placement of the device on a body surface. The sensor unit (1) has a receptacle (6), the interior of which accommodates a sensor arrangement, wherein the receptacle (6) has a sensor surface (15) in the direction of the body surface. The sensor mat (8) has a cutout (11) for accommodating the sensor unit (1) and a contact surface (14), at least partially surrounding the sensor unit (1), for placement on the body surface (9). A cover (12) is provided for closing the cutout (11) over an upper side of the sensor unit (1) and the sensor mat (8) during a measurement of parameters. The sensor unit (1), the sensor mat (8) and the cover (12) are detachable from one another.

Abstract: Provided herein is a self-contained physiological measuring device adapted for disposition within a patient body cavity, primarily the vagina, for an extended period of time (e.g., 6-48 hours or more). While disposed within the body cavity, the device periodically measures one or more physiological parameters at known locations within the body cavity. In addition to measuring such physiological parameters, the device is operative to store such measurements to memory for subsequent download/processing upon removal of the device from the body cavity and/or upon wireless interrogation.

Abstract: In a method for computing MR images of an examination object that performs a cyclic movement, MR signals are detected over at least two cycles of the cyclic movement. In each of these cycles, data for multiple MR images are recorded. Over these cycles, a magnetization of the examination object that influences the MR images approaches a state of equilibrium in a second of these cycles is closer to the state of equilibrium than in a first of these cycles. Movement information for various movement phases of the cyclic movement of the examination object is determined using the MR images from the second cycle, with movement information of the examination object determined for each of the various movement phases. Movement correction of the examination object is carried out in the MR images of the first cycle using the movement information determined in the second cycle.

Abstract: As described herein, an unknown FFR is classified based on certain extracted features. In addition, an estimation of the unknown FFR can be determined based on certain extracted features. Furthermore, a confidence interval can be determined for the estimated FFR. In another instance, boundary conditions for determining an FFR via simulation are determined. The boundary conditions can be used to classify the unknown FFR.

Abstract: An apparatus for determining a non-apparent attribute of an object having a sensor portion with which the object makes contact and to which the object applies pressure. The apparatus has a computer in communication with the sensor portion that receives signals from the sensor portion corresponding to the contact and pressure applied to the sensor portion, and determines from the signals the non-apparent attribute. The apparatus has an output in communication with the computer that identifies the non-apparent attribute determined by the computer. A method for determining a non-apparent attribute of an object.

Abstract: Systems and methods for non-invasively determining parameters related to blood glucose are disclosed. Embodiments are disclosed wherein a wearable sensor device comprises non-invasive sensors generating various sensed data which is then utilized to determine a glucose-related parameter.