Abstract: A device for monitoring arterial blood flow includes: a carrier substrate positioned on or affixed to a user's body; an array of light emitting elements on the carrier substrate, in which each light emitting element is arranged to emit light into the user when the carrier is positioned on the user's body; an array of light detecting elements on the carrier substrate, in which each light detecting element is arranged to detect light generated by one or more of the light emitting elements after the light has reflected from an object within the user's body; and an electronic controller to discretely activate one or more of the light emitting elements while simultaneously deactivating one or more other light emitting elements in the array, receive a signal generated by at least one light detecting element, and determine, based on the received signal, a condition of the user's body.

Abstract: A spectrally encoded flow cytometry (SEFC) technique for imaging blood in the microcirculation. Since the dependency of one of the axes of the image on time prevents effective quantification of essential clinical parameters, the optical path in an SEFC system is split into two parallel imaging lines, followed by data analysis for recovering the flow speed from the multiplexed data. The data analysis may be auto-correlation of a pair of images obtained from a sequence of images of the imaged blood vessel.

Abstract: A method of measuring a blood flow velocity of blood flowing in an object includes obtaining first slab data of a first imaging slab to which a first bipolar gradient is applied, obtaining second slab data of a second imaging slab to which a second bipolar gradient is applied, the second imaging slab being moved to a location different from a location of the first imaging slab, and calculating the blood flow velocity based on data included in slices of the first slab data and slices of the second slab data, the slices of the first slab data being located at a same location as the slices of the second slab data on the object.

Abstract: According to one embodiment of a device for measuring blood pressure, the device includes a pressure sensor, a microprocessor, and a user interface, wherein a user exerts pressure on the user's wrist by using the pressure sensor, the pressure sensor senses the pressure to produce oscillation signal, the microprocessor connects with the pressure sensor and receives the oscillation signal to calculate vessel pulse, systolic blood pressure, and diastolic blood pressure of the user, the user interface connects with the microprocessor and receives instruction data of the microprocessor to inform the user.

Abstract: This disclosure provides a personal hand-held monitor (PHHM) which comprises a signal acquisition device for acquiring signals which can be used to derive a measurement of a subject's blood pressure (BP), the signal acquisition device being integrated with a personal hand-held computing device (PHHCD). The signal acquisition device comprises a blood flow occlusion means adapted to be pressed against one side only of a body part or to have one side only of a body part pressed against it, a means for measuring the pressure applied by or to the body part, and a means for detecting the flow of blood through the body part in contact with the blood flow occlusion means. The blood flow occlusion means comprises at least part of an external surface of the PHHM and wherein the pressure is sensed by means of a flexible and essentially incompressible gel in which is immersed a pressure sensor. The pressure sensor is adapted to provide electrical signals to the processor of the PHHCD.

Abstract: High-accuracy magnetic measurement is performed by efficiently using nitrogen-vacancy pairs in all orientations. A magnetic measurement apparatus includes a diamond crystal and an image sensor. The diamond crystal has nitrogen-vacancy pairs. The image sensor detects the intensities of fluorescence generated by an exciting light applied to the diamond crystal by using a plurality of pixels. The nitrogen-vacancy pairs of the diamond crystal are made to one-to-one correspond to the pixels. The fluorescence generated by one nitrogen-vacancy pair is received by one pixel made to correspond to the nitrogen-vacancy pair.

Abstract: A cardiac potential measuring device comprising: a first electrode and a second electrode; a potential difference acquisition circuitry that acquires a potential difference between the first electrode and the second electrode as cardiac potential; an attachment direction detector that detects an attachment direction that is a direction of a virtual line that connects the first electrode and the second electrode attached to the body of the user; and an attachment direction calculator that calculates and outputs a preferred attachment direction in which the potential difference larger than any one of a first potential difference and a second potential difference is generated.

Abstract: Flexible high-density mapping catheter tips (10A) and flexible ablation catheter tips with onboard high-density mapping electrodes (18) are disclosed. These tips can be used for diagnosing and treating cardiac arrhythmias. The flexible, distal tips are adapted to conform to tissue and comprise a plurality of microelectrodes mounted to permit relative movement among at least some of the microelectrodes. The flexible tip portions may comprise a flexible framework forming a flexible array of microelectrodes (for example, a planar or cylindrical array) adapted to conform to tissue and constructed at least in part from nonconductive material in some embodiments. The flexible array of microelectrodes may be formed from a plurality of rows of longitudinally-aligned microelectrodes (18). The flexible array may further comprise, for example, a plurality of electrode-carrying arms or electrode-carrier bands. Multiple flexible frameworks may be present on a single device.

Abstract: Disclosed is an implantable wireless electrocardiogram sensor device, including: a cylindrical capsule provided with four recesses on a lateral surface thereof in a longitudinal direction thereof at equal intervals; electrodes installed on upper and lower surfaces of the cylindrical capsule and configured to measure electrocardiogram; a wireless electrocardiogram sensor module installed inside the capsule; a data transceiving antenna wound around two recesses symmetrical at a center; and a coil for charging wound around the remaining two recesses in a direction vertical to the antenna.

Abstract: An apparatus for transmitting electrical signals is disclosed. The apparatus includes a substrate and a twisted pair of conductors located on the substrate. The twisted pair of conductors has a first layer comprising conductive material, a second layer comprising nonconductive material, and a third player comprising conductive material. The first layer has a plurality of segments separated by a plurality of gaps. The second layer is positioned in said gaps and electrically insulates a portion of the segments positioned within the gaps. The third layer is positioned over the second layer. The third layer is configured to electrically connects an end of one segment to an end of another segment. The twisted pair of conductors formed by the three dimensional structure comprises two electrically isolated conductors twisted about each other.

Abstract: An adhesive-mountable head-wearable EEG apparatus is disclosed. The apparatus includes an EEG sensor for acquiring an EEG signal of a wearer, a central processing unit for receiving the EEG signal, a small circuit board including the EEG sensor and the central processing unit, and a compact enclosing shell for enclosing the small circuit board, the EEG sensor, and the central processing unit. An adhesive electrode assembly attaches to the compact enclosing shell, or to the small circuit board within the enclosing shell, via snaps or magnets. The adhesive electrode assembly includes two or more gel electrodes for acquiring an EEG signal, and for adhering to the forehead so as to wearably support the EEG apparatus on the forehead. The compact enclosing shell includes chamfered edges, and is sized so as to reduce lateral forces on the compact shell that would tend to detach the EEG apparatus from the wearer's forehead.

Abstract: An ECG device comprising limb leads and chest wall leads is described which is also suitable for deriving the hemodynamic activity of the heart and the function of the vessels and, respectively, also for evaluating the fluid equilibrium. This is achieved in that at least part of the electrodes of the multichannel ECG is developed with additional embodiments for physical emissions and measurements, for example, electric current and voltage, pressure, sound vibrations, light, and that an electrode is provided for the current supply and, respectively, the voltage measurement at the upper thorax aperture. Furthermore, an alternating current field is built up between the electrodes or, respectively, the distance between the electrodes is used as an ion conductor.

Abstract: A measurement method (1) for detecting vital parameters in a human or animal body, in which, in a detection step (3), a magnetic induction sensor detects an induction measurement sequence which is dependent on a time-varying change in at least one vital parameter, wherein in the detection step (3), a secondary sensor unit simultaneously detects a secondary measurement sequence, the secondary measurement sequence being dependent on an influential variable signal sequence that influences the induction measurement sequence, and in that in a subsequent combination step (4), at least one vital parameter measurement sequence for a vital parameter detected from the induction measurement sequence is calculated from the induction measurement sequence and the secondary measurement sequence using a predefined combination function, so that the detection accuracy of the vital parameter represented in the vital parameter measurement sequence and the induction measurement sequence is improved by combining the induction meas

Abstract: Systems and methods are provided for processing a set of multiple serially acquired magnetic resonance spectroscopy (MRS) free induction decay (FID) frames from a multi-frame MRS acquisition series from a region of interest (ROI) in a subject, and for providing a post-processed MRS spectrum. Processing parameters are dynamically varied while measuring results to determine the optimal post-processed results. Spectral regions opposite water from chemical regions of interest are evaluated and used in at least one processing operation. Frequency shift error is estimated via spectral correlation between free induction decay (FID) frames and a reference spectrum. Multiple groups of FID frames within the acquired set are identified to different phases corresponding with a phase step cycle of the acquisition. Baseline correction is also performed via rank order filter (ROF) estimate and a polynomial fit.

Abstract: Systems and methods for monitoring medical procedures. Particular embodiments relate to monitoring medical procedures performed in operating room environments through the use of various types of sensors.

Abstract: A method includes displaying a position of a distal end of a medical probe that is being navigated in an organ of a patient on a three-dimensional (3D) map of the organ. In response to an event, a plane of interest including the distal end is selected, a real-time Magnetic Resonance Imaging (MRI) slice of the organ is acquired at the selected plane, and the MRI slice is displayed overlaid on the 3D map.

Abstract: Devices and methods obtain and use endovascular electrograms in a number of clinical applications and settings. In one embodiment, methods for triggering analysis of an endovascular ECG waveform are based on the detection of a peak in a skin-based ECG waveform in order to determine a location of an indwelling medical device, such as a catheter. In another embodiment, the position of a catheter or other medical device within the vasculature can be determined by analysis of the energy profile of a detected P-wave. In yet other embodiments, magnetic connecting devices are used for establishing an operable connection through a sterile field.

Abstract: Methods of using subcutaneously implantable sensor devices and associated systems having a communication module that is controlled based upon the detection of a predetermined chemical agent.

Abstract: First RGB image signals are inputted. Color difference signals Cr and Cb are calculated from the first RGB image signals. In a feature space formed by the color difference signals Cr and Cb, a first process and a second process are performed. In the first process, coordinates which correspond to the first, second, and third observation areas are moved in a parallel manner such that the coordinates which correspond to the second observation area are moved to a reference area that contains the origin point. In the second process, the coordinates which correspond to the first observation area and the coordinates which correspond to the third observation area are moved away from each other.

Abstract: A modular instrumented floor covering assembly is used in connection with a subject walking across the assembly. The floor covering assembly comprises a plurality of sensor panels attached together along interlocking edges. The edges are held together by interlocking strips or by magnets. Each sensor panel has a pressure sensor matrix responsive to the weight of the subject for generating data relating to movement of the subject. The sensor panels are assembled on the floor selectively and releasably in patterns. No tools are needed for assembly. Data is sent wirelessly between the sensor panels and from the sensor panels to a computer for analysis. A power supply, wiring grid, and releasable connectors on the panel edges supplies electrical power to the sensor panels and between adjacent sensor panels.

Abstract: According to one embodiment, a respiratory measurement module measures a first signal related to a respiratory fluctuation of the user. A body movement measurement module measures a second signal related to a movement of a trunk of the user. A respiration detector detects whether or not the user is in a respiratory arrest state, based on the measured first signal measured. A body movement detector detects whether or not the trunk of the user is moving, based on the measured second signal. An estimation module estimates a respiratory state of the user, based on a detection result by the respiration detector and a detection result by the body movement detector. An output module outputs respiratory state information indicating the estimated respiratory state.

Abstract: A device for detecting an unacceptable deviation from a neutral spine position in a user is provided. The device is configured to determine changes in orientation and curvature of the user's back, and comprises a first sensor configured to determine the change in orientation, a second sensor configured to determine the change in curvature, a signaling mechanism configured to issue an alert to the user, an attachment element configured to maintain the device on the user, and a controller configured to determine that an unacceptable deviation has occurred based on readings of the first and second sensors.

Abstract: Embodiments are disclosed to automatically reset tracked physical performance information determined based on motion data generated using a sensor configured to measure motion of a user wearing a fitness monitoring device by calculating, utilizing the motion data, a reset time when a period of inactivity within each of a plurality of consecutive sampling periods exceeds a threshold time period. The fitness monitoring device may determine, utilizing the motion data stored over an extended period of time, an approximated midnight time and adjust the reset time to equal the approximated midnight time. The fitness monitoring device may generate motion data to track a number of steps achieved towards a goal, which may represent a threshold number of steps to be taken over a period of time. Embodiments also include utilizing other sensor data, such as light intensity data, to determine when a user is likely asleep.

Abstract: According to an example, an apparatus for performing spectroscopy includes an elongated substrate having a shape and size to be inserted into a specimen, wherein the elongated substrate has a first end and a second end. The apparatus also includes a plurality of surface-enhanced spectroscopy (SES) elements positioned on an exterior surface of the elongated substrate at a location between the first end and the second end of the elongated substrate.

Abstract: Improved monitoring of one or more blood coagulation factors is provided. Factor-specific molecular probes having a dye-quencher arrangement are employed. In preferred embodiments, a compact integrated optical source and detector device is used for fluorescence measurements. Continuous and real-time monitoring of the activity of one or multiple blood factors is provided. Such real-time information can be used to automatically control delivery of drugs such as coagulants and/or blood thinners.

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous and subcutaneous measurement of glucose in a host.

Abstract: Devices and methods for monitoring an analyte are provided. Embodiments include continuous analyte sensors having a high degree of accuracy.

Abstract: A lancet device includes a housing, a removable front cap mounted to the housing, a lancet holding member, a trigger and an arming system comprising a grippable cocking member structured and arranged to place the lancet device in a trigger-set or armed position. A depth adjustment system includes a member that is at least slidable and partially rotatably mounted and that has an axis of rotation arranged substantially parallel to a center axis of the lancet holding member. An ejection system includes an ejector having a portion extending outside a sidewall opening of the housing and being located closer to a front end of the housing than to a rear end of the housing. The sidewall opening of the housing is arranged on an area of the housing located between the trigger and a wall of the housing located opposite the trigger. The ejection system is structured and arranged to at least one of prevent axial movement of the lancet holding member or remove or eject a lancet from the lancet holding member.

Abstract: The present invention is directed to an automated vessel puncture device, methods of mapping three-dimensional views of subcutaneous vessels and methods for providing simultaneous real-time diagnostic assay.

Abstract: An oral detection device is used for making oral detection of gastroesophageal reflux disease or other diseases or disorders. It includes a sensor, a sensor container, a base and a tooth retainer. The sensor is held in the sensor container and got its orientation maintained towards the esophageal opening. The tooth retainer works to connect the base where the sensor container and the sensor within are secured to, to teeth in either a maxillary style or a mandibular style. In this way, the oral detection device is able to detect gastroesophageal reflux or other targets in mouth in a removable and reusable way.

Abstract: A system and method for the non-invasive measurement of tone, state of tension, biomechanical or viscoelastic properties of soft biological tissues includes a testing-end, an actuator arranged to apply a force to the testing-end, and a sensor to sense movement of the testing-end. A signal generating circuit supplies a control signal to the actuator so the biological tissues are subjected by the testing-end to a load, including means to adjust the signal provided by the signal generating circuit in accordance with the component of weight acting through the testing-end onto the biological tissue so that the load to which the biological tissue is subjected is constant. An impulse signal generating circuit supplies an impulse signal to the actuator so the biological tissue is subjected by the testing-end to a mechanical deformation. In use the soft biological tissue is subjected first to the constant load, and then to the impulse signal; and the consequent movement of the biological tissue is then registered.

Abstract: A method and system are provided for characterizing a portion of biological tissue. A surface of the tissue is illuminated with light having a known wavelength spectrum capable of materially penetrating the tissue. The intensity of the illumination light remitted from the tissue in response to the illumination over a known measurement window is measured over a hyperspectral range of wavelengths for at least two distinguishable polarization components. Based on a model of the response of the tissue and the preceding measurements, data representative of the location and one or more characteristics of an abnormal portion of the tissue are produced. A method is provided to eliminate the masking effect of melanin to obtain accurate estimations of an anomaly.

Abstract: Methods and apparatus are described for detecting acne, particularly in its earliest stages before any humanly visible or palpable manifestations thereof have emerged. An arrangement is described in which a green fluorescence image of an area of skin illuminated with blue light is captured and processed to detect the presence of microcomedones. The captured green fluorescence image is corrected for the non-uniform distribution of excitation light on the surface of the illuminated area of skin. Fluorescent spots are then detected in the corrected image. The subset of fluorescent spots having an intensity lower than an intensity threshold and an area smaller than an area threshold are selected as representative of candidate microcomedones. The subset can be further refined by eliminating fluorescent spots that have irregular shapes, are associated with inflammation, or exhibit comedone features. Additional filtering can be applied by selecting those spots whose locations correspond to those of pores.

Abstract: A method for controlling gait-training apparatus using biofeedback is provided. A biosignal-detecting loop is used to detect and analyze the electromyographic signal of a user using the gait-training apparatus. A feedback control loop is used to drive the gait-training apparatus and determine the fatigue level of the user. When the user's muscle starts to become fatigue, the feedback control loop can further adjust the threshold for triggering the gait-training apparatus to retain the training session so that the training intensity can be regulated on-line and the user's muscle can be trained effectively based on the concept of progressive overload.

Abstract: According to one embodiment, a sleep state estimation device attached to a user during sleep and used is provided. The device includes a first detector, a first estimation module, a second detector, and a second estimation module. The first detector is configured to detect a first signal, to estimate a first state of the user. The first estimation module is configured to estimate the user's first state, based on the first signal. The second detector is configured to detect a second signal to estimate a second state of the user other than the user's first state. The second estimation module is configured to estimate the user's second state by using the second signal, based on an estimation method determined in accordance with the first signal.

Abstract: The invention is directed to a system and method using the system for guiding a person in correct activation of her or his core muscles for a sport or other exercise session The system is based on an elastic belt to be closely adhered to the lower abdomen of the human being and adapted to follow an inward movement of the lower abdominal wall without movements of the spine and pelvis effectively activating the core muscles responsible for low back control, sensor means provided at the belt for capturing extensions and contractions of the belt following said inward movement of the lower abdominal wall, means for evaluating the extensions and contractions of the belt following said lower abdominal wall region and for outputting evaluation data, means for comparing the evaluation data attained thereby to data representing correct activation of the core muscles, and feedback means provided with the belt for providing feedback to said result of said comparison to said person.

Abstract: The present invention relates to a new integrated, holistic approach to empower older adults to enhance their quality of life and independence through a personalized lifestyle and nutrition program. This is achieved by measuring the physical status of the adults with respect to strength and endurance. In addition, their nutritional status is assessed. Based on those assessments recommendations are provided with respect to particular exercise programs and nutrients that support the functions bones, muscles and cartilage. These methods can be implemented as a software program and executed on computer systems.

Abstract: An example system includes a physiological sensor for generating physiological data associated with a user bearing the physiological sensor. The physiological sensor is configured to wirelessly communicate the physiological data. A portable device includes a touch input device; an accelerometer for generating accelerometer data indicative of activity of the user; wireless communication circuitry for receiving the physiological data; memory for storing the accelerometer data and the physiological sensor data; and a vibrator for providing tactile output to the user. The wireless communication circuitry transmits the physiological data and the accelerometer data to a computer device for use in a presentation application.

Abstract: The invention relates to the field of mobile training data acquisition in sport, particularly in strength training, body building, fitness sports and rehabilitation, as well as the analysis of said training data. The invention involves a method and a mobile device (1) for precise acquisition of multiple training data. The multiple training data includes, for example, the time-path curve of the force application point of the training load, the mechanical work and the tension duration of eccentric and concentric muscle length changes and isometric muscle contractions. An analysis of the training data is based on a training model (25).

Abstract: According to one embodiment, a sleep sensor which is attached to a user who is sleeping when it is to be used is provided. The sleep sensor includes a first detector, an estimation module, a second detector and a control module. The first detector is configured to detect an acceleration signal representing acceleration that is obtained from the sleep sensor. The estimation module is configured to estimate the user's body position based on the detected acceleration signal. The second detector is configured to detect a signal for estimating a state other than the user's body position. The control module is configured to operate the second detector when the estimated user's body position is at least one of predefined body positions.

Abstract: The present invention rapidly reacts to changes in the degree of anesthesia to provide an accurate and timely anesthetic depth measurement result, and a method for measuring anesthetic depth comprises the steps of: an epoch dividing portion generating an epoch signal by dividing a EEG signal into a plurality of numbers based on time units, a coefficient portion extracting a CAI calculation value (CAI) by calculating the number of points in an epoch having a value higher than an established critical value, a Shannon entropy calculating portion extracting a Shannon entropy calculation value (ShEn) by conducting a Shannon entropy-calculation from the EEG signal, and a spectra entropy calculating portion extracting a spectra entropy value (SpEn) by conducting a spectra entropy calculation; an improved Shannon entropy extracting portion extracting an improved Shannon entropy calculation value (MshEn) by multiplying the Shannon entropy calculation value (ShEn) and the spectra entropy calculation value (SpEn); and a

Abstract: The respiratory exercise device comprises means for detecting the respiration of a person and it is characterized in that said means for detecting the respiration of a person comprises a turbine whistle (3) which generates a variable frequency sound as a function of the air flow which passes through the same and a microphone (4) which captures said variable frequency sound generated by the turbine whistle (3). The method for respiratory exercise comprises the steps of obtaining data relating to the respiration of a person with the previous device, sending said data relating to the respiration to control means; and applying an algorithm to said data for calculating the values of the flows generated by the respiration. It allows respiratory exercise to be carried out in a simple manner, even for children.

Abstract: The present invention provides a diagnostic imaging system (100), comprising a magnetic resonance (MR) imaging system (110) for providing an image representation of at least a portion of a subject of interest (120) positioned in an examination space (116), a hyperthermia device (111) for locally heating a target zone within the portion of the subject of interest (120), and a control unit (126) for controlling the MR imaging system (110) and the hyperthermia device (111), wherein the diagnostic imaging system (100) is adapted to provide a diagnostic image representation of the portion of the subject of interest (120) by correlating image representations obtained at different temperatures of the target zone, wherein the diagnostic image representation comprises information on temperature dependent changes of the metabolism of the subject of interest (120).

Abstract: The invention relates to a detection system of an endo-urethral device for an artificial urinary sphincter implantable in the body of a patient, said sphincter comprising an occlusive cuff (2) adapted to compress the urethra, the bladder neck or the prostate of said patient, an activation device (5) of said cuff (2) and a control unit (6) adapted to control the activation device. Said system comprises at least one compression sensor (13) of the urethra and a posture sensor (9), and a processing unit (30) configured to determine: (i) if the compression parameter of the urethra exceeds a predetermined threshold during a predetermined period, (ii) if the patient is in a recumbent position. If the conditions (i) and (ii) are fulfilled, the processing unit sends to the activation device (5) an immediate reduction order of the compression exerted by the cuff (2).

Abstract: The invention is a system for monitoring and reporting the activity level and caloric expenditure of an individual. The system has sensors in electronic communication with a wearable device. A processor is programmed to communicate with the sensor and a computing device to activity data from movement-related data. A remote server receiving the activity data and the data from computing device, and generates a graphical presentation. The graphical presentation comprises information related to the activity data. The wearable device also provides visual and audio data.

Abstract: Measuring expended energy of a moving body by providing at least one first sensor for measuring position data of a first part of the moving body, providing at least one second sensor for measuring relative position data of a second part of the moving body, using the first sensor to make a first measurement of the position of the first part over a period of time and subsequently calculating a global expended energy of the first part relative to a reference frame from the first measurement, using the second sensor to make a second measurement of the position of the second part over said period of time and subsequently calculating a relative expended energy of the second part relative to the first part from the first and second measurements.

Abstract: Dual-energy absorptiometry is used to estimate visceral fat metrics and display results, preferably as related to normative data. The process involves deriving x-ray measurements for respective pixel positions related to a two-dimensional projection image of a body slice containing visceral fat and subcutaneous fat, at least some of the measurements being dual-energy x-ray measurements, processing the measurements to derive estimates of metrics related to the visceral fat in the slice, and using the resulting estimates. Processing the measurements includes an algorithm which places boundaries of regions, e.g., a large “abdominal” region and a smaller “abdominal cavity” region. Two boundaries of the “abdominal cavity” region are placed at positions associated with the left and right innermost extent of the abdominal muscle wall by identifying inflection of % Fat values.

Abstract: A device for detecting spatial differences in fluid level changes in a tissue of a patient may include a support structure for securing the device to a body part of the patient, a processing element operably connected to the support structure, a wireless networking interface operably connected to the support structure and in communication with the processing element and an external computing device via a network, a first transmission module operably connected to the support structure and in communication with the processing element, a second transmission module and a third transmission module operably connected to the support structure and in communication with the processing element. When activated, the first transmission module transmits a first time varying magnetic field through the tissue of the patient. The second and third transmission modules, which are spatially separated from one another, receive first and second versions, respectively, of the first time varying magnetic field.

Abstract: A baby foot strap comprises a strap with an opening for a heel and a flange that wraps over the top of the foot, and at least one sensor attached to an interior of the strap, so as to monitor one or more desired health parameters of the baby.

Abstract: Provided herein is an integrated wireless patch comprising a contact layer, an electronics layer, and a battery layer. The contact layer is a substrate having gel cutouts. The electronics layer can be folded into contact with the contact layer. The battery layer can be folded into contact with the electronic layer. Further provided herein is a method of manufacturing a wireless integrated patch comprising folding a substrate comprising at least one cutout, at least one contact disk in communication with a surface of a patient through the cutout, and battery terminals, wherein the at least one cutout, the at least on contact, and the battery terminals are adaptable to be located in different layers after the substrate is folded.