Abstract: A delivery device for a prosthetic heart valve includes a shaft, a sheath, and a pull wire. The shaft has a proximal end, a distal end, and a longitudinal axis. The sheath is attached to the shaft and is rotatable about an axis transverse to the longitudinal axis of the shaft. The pull wire is mechanically coupled to the sheath such that movement of the pull wire rotates the sheath relative to the shaft. The sheath may be in a first position relative to the shaft when a distal end of the pull wire is in a first position and may be in a second position when the distal end of the pull wire is in a second position. Deflection of the sheath relative to the shaft enables a prosthetic valve to be axially aligned with the native valve annulus for deployment.

Abstract: The diameter of an annulus in a patient (e.g., the mitral valve annulus) can be reduced using a tissue engaging member that is installed on the annulus and an actuator that is implanted into the patient's body. The tissue engaging member has anchors used to implant the tissue engaging member into the annulus, and a cinching loop runs through the tissue engaging member. The cinching loop terminates onto cinching wires. Preferably, tissue healing is used to enhance the bond between the tissue engaging member and the annulus. The actuator, which can be actuated from outside the patient's body, pulls the cinching wires in a proximal direction while holding the distal end of the cinching wires in close proximity to each other, so as to cause a reduction in the diameter of the cinching loop. This will cause a corresponding reduction in the diameter of the annulus.

Abstract: A bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of milled and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder on the coherent mass. In some embodiments, a method of implanting a bone material is provided, the method comprising contacting the bone material with a liquid, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass; molding the bone material into a shape to implant the bone material; and implanting the bone material at the target tissue site.

Abstract: A three component system for repairing critically sized bone defects having a first shape memory polymer (SMP) component formed as a scaffold that fills the defects, a second SMP component formed as a restricting sleeve that stabilizes and supports osseointegration and osteoconduction, and a third SMP component formed as a two-dimensional cell culture substate for engineering periosteal grafts.

Abstract: The invention provides treatment methods of using meniscus to repair injured and/or arthritic joints, for example, small hand joints including but not limited to radiocarpal, metacarpophalangeal, and interphalangeal joints. The invention also provides various implants made of meniscus for injured and/or arthritic joints.

Abstract: A partial resurfacing implant for use in repairing an articular cartilage defect site that includes a top articulating portion having a top surface that is configured with at least one radius of curvature to approximate the surface contour of the articular cartilage surrounding the defect site. The implant also includes a supporting plate that has a top surface and a bottom surface. The top surface is attached to the top articulating portion by a locking mechanism. The bottom surface of the supporting plate is constructed to facilitate the insertion of the implant into the defect site. Extending from the bottom surface of the supporting plate is at least one implant fixation portion. The at least one implant fixation portion is integrally connected to and is oriented about normal relative to the bottom surface. A method of repairing an articular cartilage defect with the partial joint resurfacing implant is also disclosed.

Abstract: An acetabular hip implant includes an acetabular shell component having a first feature and a first insert having a second feature that cooperates with the first feature of the acetabular shell component and further includes a third feature. The implant further includes a second insert having a fourth feature that cooperates with the third feature of the first insert and further includes a fifth feature. A femoral head component includes a sixth feature that cooperates with the fifth feature. Interaction between the first and second features, between the third and fourth features, and between the fifth and sixth features mechanically constrains the acetabular hip implant to prevent dislocation of the femoral head during rotation.

Abstract: A tibial prosthesis has a bearing component configured for an anterior-medial insertion, which advantageously avoids the extensor mechanism of the knee. A tibial tray may include a banana-shaped boss that corresponds to a notch formed in the bearing component. After the bearing component is inserted along the anterior-medial path, the boss is received within the notch by rotating the bearing component with respect to the tibial tray. This rotation seat the bearing component upon the tibial tray in the manner of a fixed-bearing prosthesis. Alternatively, the boss and notch may define angled central axes which allow straight anterior-medial insertion of the bearing component and locking engagement to the tibial tray.

Abstract: An expandable medical implant is provided with an implantable cage body. The proximal and distal ends of the cage body may each be provided with a tapered or cam portion. The implant may further include a proximal flexure, a distal flexure, a proximal plug member having a tapered portion configured to mate with the tapered portion of the proximal end of the cage body, and a distal plug member having a tapered portion configured to mate with the tapered portion of the distal end of the cage body. The proximal plug member may be configured to move longitudinally such that the distal flexure moves and the circumference of the proximal end of the cage body resiliently expands. The distal plug member may be configured to move longitudinally such that the proximal flexure moves and the circumference of the distal end of the cage body resiliently expands. Methods are also disclosed.

Abstract: An implant or endoprosthesis suitable to be implanted in human or animal tissue includes two (or more than two) parts to be joined in situ. Each one of the parts includes a joining location, the two joining locations facing each other when the device parts are positioned for being joined together, wherein one of the joining locations includes a material which is liquefiable by mechanical vibration and the other one of the joining locations includes a material which is not liquefiable by mechanical vibration and a structure (e.g. undercut cavities or protrusions) suitable for forming a positive fit connection with the liquefiable material. The joining process is effected by pressing the two device parts against each other and by applying ultrasonic vibration to one of the device parts when the two parts are positioned relative to each other such that the two joining locations are in contact with each other.

Abstract: A spinal implant comprises a first member including a wall that defines a first cavity and a second member including a wall defining a second cavity. At least one first expandable bone graft is disposable within the second cavity. The second member is axially translatable relative to the first member between a first configuration and a second, expanded configuration such that at least a portion of the at least one first graft is disposed within the first cavity and the first cavity includes a substantially void portion. At least one second bone graft has a selective configuration and dimension for disposal within the substantially void portion. Systems and methods are disclosed.

Abstract: An orthopaedic impactor includes an elongate member having an interface end; an impact head connected to the elongate member; an implant interface held at the interface end that is configured to connect to an acetabular cup; and a securing mechanism attached to the elongate member that includes an actuator and a pressing member at least partly covering the implant interface. The pressing member is connected to the actuator and slidable relative to the implant interface. The actuator is configured to slide the pressing member along the implant interface.

Abstract: A surgical instrument for operating hip joint osteoarthritis in a human patient is provided. The hip joint comprises an acetabulum, being a part of the pelvic bone, and a caput femur, being the proximal part of the femoral bone. The surgical instrument is adapted to assist in the operating of the hip joint osteoarthritis from the abdominal side of the pelvic bone of said human patient.

Abstract: A cup and a temporary insert are respectively configured to be tightly press fitted into each other along their periphery. The temporary insert includes a through hole communicating outside with a free space between the outer surface of the temporary insert and the inner surface of the cup. In the through hole can be engaged the threaded end of an impactor. for manipulating the cup when it is being set. A syringe can be engaged, enabling a liquid under pressure to be injected into the free space, thus separating the temporary insert from the cup without any risk of damaging the inner surface of the cup. Thus, the cup can be securely manipulated when it is being set without any risk of damaging the inner surface of the cup.

Abstract: The present invention provides an expandable fusion device capable of being installed inside an intervertebral disc space to maintain normal disc spacing and restore spinal stability, thereby facilitating an intervertebral fusion. In one embodiment, the fusion device includes a body portion, a first endplate, and a second endplate, the first and second endplates capable of being moved in a direction away from the body portion into an expanded configuration or capable of being moved towards the body portion into an unexpanded configuration. The fusion device is capable of being deployed and installed in both configurations.

Abstract: A mechanical finger comprises a plurality of phalanges coupled to a single actuator using a kinematic linkage and a differential linkage arranged in parallel. The mechanical finger is capable of exhibiting consistent predictable motion when moving in free space or when contacting an object at the fingertip, and of curling in order to conform to an object when the contact is at other locations on the finger.

Abstract: The present invention is directed to prosthetic device for attaching a mechanical limb to a user. The prosthetic device includes a liner, a prosthetic socket worn over the liner and an attachment mechanism. The attachment mechanism includes a belt that is guided over rollers coupled to the outside of the socket. A portion of the belt passes from the outer surface of the socket to the inner surface of the prosthetic socket to contact and matingly engage the liner, thereby fixing the position of the prosthetic socket with respect to the liner and the users limb.

Abstract: An array of a plurality of shape memory material microposts have a proximal end configured to be secured to a substrate with a tissue penetrating distal end.

Abstract: An endoluminal prosthesis system for a branched body lumen comprises a branch vessel prosthesis. The branch vessel prosthesis is deployable within a branch vessel body lumen and comprises a stent having a generally tubular body portion, a flareable proximal end portion, and a coupling portion disposed intermediate the body portion and the flareable portion. The coupling portion is more crush-resistant than the body portion. The flareable proximal end may be disposed within a fenestrated stent graft wit with coupling portion disposed in the fenestration of the fenestrated stent graft.

Abstract: Method for sealing a stent graft in an endovascular aneurysm repair. Includes following steps/procedures. Positioning the stent graft to extend across an aneurysm in aneurysmatic host vessel. Introducing and placing a balloon catheter in the host vessel at a location distal to the graft distal end. Inflating balloon to pressure configured for unconstrained balloon expansion with maximal balloon diameter equal to or greater than smallest inner diameter of host vessel, thereby occluding normal blood flowing thereacross. Infusing contrast enhancing material through balloon catheter for allowing radiographic visualization of endoleakage between stent graft and a host vessel wall. Deflating and repositioning balloon to another location within stent graft. Pressurizing balloon to another pressure configured for plastically expanding selected section of stent graft from a smaller diameter to a fixed enlarged diameter.

Abstract: The present invention relates to a deployment handle for a prosthesis delivery device and to a delivery device including such a handle. The handle assembly facilitates the controlled release of a prosthesis from the delivery device, while ensuring that various deployment steps are performed in a particular sequential order. The handle assembly comprises a main handle and a second handle which is rotatably and/or longitudinally moveable relative to the main handle. The second handle has an initial position on the main handle such that it prevents access to, and premature manipulation of, a proximal stent release mechanism, until the stent graft has been at least partially unsheathed.

Abstract: Stent delivery systems and methods for making and using stent delivery systems are disclosed. An example stent delivery system may include an inner shaft. A deployment sheath may be disposed about the inner shaft. A stent may be disposed between the inner shaft and the deployment sheath. A stent reconstraining member may be secured to an inner surface of the deployment sheath and releasably secured to the stent.

Abstract: A medical implant delivery device includes an elongate carrier which includes a device holding member at its distal end, attached to a catheter element. The device holding member includes at least one channel extending along its length. A pusher element, in the form of an outer catheter, is disposed over the elongate carrier and provides a pusher shoulder. A medical device can be held on the device holding member. An outer sheath is typically disposed over the implant delivery device, in known manner. The device holding member is made of a resilient material able to compress radially inwardly, particularly by compression of the walls bounding the channel. The compressibility of the device holding member reduces the friction between the medical device and the carrier sheath as well as the force required to retract the outer sheath during the deployment of the medical device.

Abstract: A stent delivery system is disclosed in which a stent is contained in a sheath in an initial state and the stent is released inside a living body lumen in accordance with a movement of the sheath in a proximal direction with respect to an inner member. A movement mechanism of the stent delivery system has a rack member which is connected to a proximal end of the sheath, and a plurality of pinions which move the rack member in accordance with rotations thereof.

Abstract: Method and apparatus for limiting absorption of food products in specific parts of the digestive system is presented. A gastrointestinal implant device is anchored in the stomach and extends beyond the ligament of Treitz. All food exiting the stomach is funneled through the device. The gastrointestinal device includes an anchor for anchoring the device to the stomach and a flexible sleeve to limit absorption of nutrients in the duodenum. The anchor is collapsible for endoscopic delivery and removal.

Abstract: An apparatus comprises a sleeve, a seal, and an anchor assembly. The sleeve is flexible and non-permeable and is configured to fit in a duodenum. The seal is positioned at the proximal end of the sleeve and is configured to seal the proximal end of the sleeve against the stomach mucosa, the pylorus, or the duodenum mucosa. The anchor assembly comprises a pair of atraumatic anchor ends and a resilient member positioned between the anchor ends. At least a portion of the resilient member extends along at least a portion of the length of the sleeve. The resilient member is configured to bias the anchor ends generally toward each other, to thereby substantially anchor the sleeve in the duodenum. The sleeve is configured to prevent chyme from contacting the mucosa of the duodenum; and to prevent enzymes excreted in the duodenum from mixing with chyme in the duodenum.

Abstract: An orthosis for supporting a human ankle joint is described. The orthosis may include a foot section and a tibial section, with a tensioning mechanism configured to adjust the tension between the foot section and the tibial section in order to change the range of motion of the joint. Methods for assembling and using an orthosis are also described.

Abstract: The invention relates to a neck brace comprising a deformable brace, said deformable brace is provided with a removable cushion fixed thereon by a tie; said deformable brace is additionally provided with two movable sponge sleeves, and the two movable sponge sleeves slide along the deformable brace. the neck brace consists of a deformable brace, with one end supporting the head and the other end attached onto the body to distribute the weight of the head to other parts of the body through the brace, and reduce the pressure applied to cervical vertebra, thus protecting the cervical vertebra; a removable cushion is provided on one end of the brace, which can improve comfort degree of the product; two thickened sponge sleeves are provided in the middle of the structure, which can produce enhanced comfort when the brace is in contact with the body.

Abstract: A two layered device for opening nasal passages, the device comprising: a circular pad having an adhesive underlay surface, a smooth overlay surface, and a center soft plastic compression material within the underlay surface thereof for applying the pad on each side of a human nose, within the Maxillary Sinus areas. The Sinus Nasal Pads placed in the Maxillary Sinus area enables the Nasal Passage to open and providing relief from nasal congestion.

Abstract: Method and system is disclosed for manufacturing an orthopedic insert. The process includes, initializing a plurality of sensors as pixel-based information, making one or more pressure measurement from each of the plurality of sensors, analyzing and conditioning the pressure measurements to derive a pressure value for each pressure sensor, converting the pressure values into a pixel intensity value, mapping the pixel intensity values to a graphic image, determining pixel intensity values between each mapped pixel intensity value along a first axis, determining pixel intensity values along a second axis, and machining an orthotic insert based upon the graphical image.

Abstract: Provided herein are medical drainage systems comprising structures to prevent blockages within drainage tubing, especially medical drainage tubing, for example caused by debris or airlocks. The novel systems of the invention employ, in some embodiments, elements of the Archimedian screw. The Archimedian screw elements comprise a rotating conveyer present in the tubing which promotes continuous flow of material through the tubing and prevents the formation of dependent loops and other blockages. The systems of the invention may be employed in diverse contexts, including urinary catheter drainage systems and thoracostamy systems. The systems of the invention, being gravity independent, may also be employed for the drainage or a movement of materials in space and other low gravity environments.

Abstract: A drainable ostomy pouch includes a collection portion and a drain chute portion extending from the collection portion and having a discharge opening for permitting emptying of contents from the pouch. The drain chute is foldable between an open condition in which the drain chute portion is extended from the collection portion, and a closed condition in which the drain chute portion is folded towards the collection portion. At least one flap retains the folded drain chute portion.

Abstract: An occlusive device can reversibly block flow through a lumen of a patient, such as a blood vessel, a reproductive structure, a ureter, a colon, and other body lumens. The device can include a frame comprising having a distal portion that tapers inwardly toward a central axis of the frame. The frame can expand from a compressed configuration to a deployed configuration. The device can also include a flow reducing member coupled to the frame for restricting flow through the lumen and a withdrawal component that can engaged by a retrieval device to retrieve the device from within the lumen.

Abstract: Exemplary embodiments of the present disclosure provide method and apparatus for effecting (e.g., lightening) an appearance of skin by cooling or freezing small separated surface regions of the skin to produce regions of local hypopigmentation. The width of the regions can be, for example, smaller than about 1 mm or 0.5 mm, and a distance between these frozen regions can be greater than about 3 times the width of the regions. An exemplary apparatus can be provided that includes a plurality of spatially-separated thermally conductive arrangements that can be affixed or otherwise coupled to a base. For example, the conductive arrangements can be regions of conductive material provided in or proximal to a thermal insulator, or thermally conductive protrusions affixed to the base. The conductive arrangements can be cooled and then contacted with the skin surface to produce the small regions of hypopigmentation.

Abstract: The present invention is directed to a device for absorbing heat from a body. More particularly, the invention pertains to an improved device which utilizes a gel material comprising liquids and solids to absorb, over an extended period of time, heat from a body.

Abstract: The invention relates to a method and apparatus for controlling the inner temperature of a patient, comprising the steps of creating a fluid circuit that comprises a patient and a heat exchanger, the power supply thereto being controlled by a controller; subjecting at least a portion of the fluid in said circuit to the heat exchanger; directing the subjected fluid to and into the patient to control the temperature of the patient; estimating the organ temperature of the patient by a model that has been obtained on a mammal other than the patient; and controlling the power supply to the heat exchanger such that the estimated organ temperature does not exceed a threshold organ temperature, potentially taking into account estimated future organ temperatures. The invention further relates to a method and apparatus for controlling the inner temperature of a patient when subject to whole body hyperthermia, and to a method for obtaining the model.

Abstract: Apparatus is provided, including an external device, including a mount, placed in front of an eye, and a laser which emits toward the eye radiation that is outside of 380-750 nm. The apparatus additionally includes an intraocular device which is implanted entirely in the eye, and includes an energy receiver, a plurality of stimulating electrodes, a plurality of photosensors, and driving circuitry coupled to the energy receiver and to the photosensors, and configured to drive the electrodes to apply currents to a retina of the eye in response to the signals from the photosensors. The photosensors are (a) generally insensitive to the energy from the laser, and (b) generally sensitive to visible light. Other applications are also described.

Abstract: A nozzle unit for cross-linking of eye tissue is disclosed. The nozzle unit comprises a dosing device for providing a predefined dose of a photosensitizer, a pressure-generating device for generating a pressure in the dosing device, and an outlet nozzle for discharging the dose of the photosensitizer, in a puff-type manner and in the form of at least one stream or stream bundle, through an outlet opening of the outlet nozzle.

Abstract: A system for preparing an intraocular lens (IOL) injector for receipt of an IOL. A manifold mates with an injector cartridge and easily distributes a lubricating agent to a load chamber of the cartridge. The IOL is then transferred into the load chamber. The cartridge may be rotatably coupled to the handpiece, and then converted from a preparation and load position to a delivery position. The manifold may remain external to the load chamber or fit within the load chamber and include a handle that remains outside. One or more internal channels in the manifold lead from one or more inlet ports to surfaces in the load chamber than contact the IOL.

Abstract: A vitrectomy probe includes a hand-graspable body and an outer tube extending from the hand-graspable body. The outer tube includes a closed distal end and a first port sized to receive tissue. The vitrectomy probe also includes an inner tube within the outer tube with a second port that is selectively alignable with a portion of the first port to allow fluid flow and uniquely sized to increase fluid flow. The inner tube includes a distal tip with a cutting edge on each of the distal and proximal sides of the tip. The distal tip has a smaller diameter than that of the inner tube at a proximal side of the second port. The proximal side of the second port includes a guiding surface that slidably bears on an inner surface of the outer tube to prevent the distal tip from excessively protruding from the first port of the outer tube.

Abstract: A delivery system is disclosed which can be used to deliver an ocular implant into a target location within the eye via an ab interno procedure. In some embodiments, the implant can provide fluid communication between the anterior chamber and the suprachoroidal or supraciliary space while in an implanted state. The delivery system can include a proximal handle component and a distal delivery component. In addition, the proximal handle component can include an actuator to control the release of the implant from the delivery component into the target location in the eye.

Abstract: Glaucoma can be treated by implanting an intraocular shunt into an eye. The eye has an anterior chamber and sclera. A shunt can be placed into the eye to establish fluid communication from the anterior chamber of the eye through the sclera.

Abstract: An intraocular shunt deployment device can release an intraocular shunt into an eye using a deployment mechanism that coordinates action between a pusher component, a shaft component, and a housing of the device. The deployment mechanism causes axial movement of the components in response to a rotational input force.

Abstract: The present invention describes an earwax removal device having varying structures to provide different earwax removal capabilities. In all designs, the overall contour of the earwax-extracting member resembles the dimensions of the external auditory canal and is flexible enough to conform to it during insertion. Each engages and collects wax using the pressure of insertion and rotation effects. Embodiments include a club-like member having multiple protrusions and extractions to collect wax along its sides, and an opening in the tip that leads to a channel to collect wax; a flexible spiral member to compress when the device is inserted in an ear and thereby extract wax as it expands when the device is removed; a screw-like structure to laterally move wax and grind as it rotates; a multi-channel structure to cut and collect wax simultaneously; and a shovel-like structure to effectively shear and scrape wax from an ear canal.

Abstract: A device with an adjustable horizontally faced adjustable headband, including recyclable plastic elements of and adapter that attaches multiple spherical cups. Attached to the spherical cups are styrofoam liners, which provide comfort and solidify sounds within the ear canal for a personal amphitheater experience.

Abstract: A combined compression and absorption dressing/bandage, which includes a short stretch compression bandage and at least one absorptive wound dressing comprising at least one absorbent layer of a non-woven fabric of any one or more of cotton, viscose and polyester fibres, the absorbent layer having an operative inner face and an operative outer face, the at least one wound dressing being bonded to the short stretch compression bandage with its inner face towards the bandage and the outer face facing away from the bandage.

Abstract: A wound care device for the treatment of wounds is disclosed by means of atmospheric negative pressure in the wound region, including a wound-covering element that can be attached to the skin of a patient as well as a connection device for the suctioning of fluid media, wherein the wound-covering element includes a window that can be opened, which window is arranged on the wound-covering element by means of a gas-tight closure.

Abstract: A bandage system for dressing a wound. The bandage system includes an elongated bandage formed into a roll that can be cut to the size necessary to cover the user's wound. A separate strip of adhesive tabs is provided, wherein the adhesive tabs are removably secured to one another via perforated lines of connection. The adhesive tabs include a smooth outer surface and an underside surface having a pressure sensitive adhesive thereon. The adhesive tabs can be placed orthogonally to the bandage so as to be adhered to the user's skin and the bandage in order to securely position the bandage on the user. Additional adhesive tabs can be used to secure the bandage in the desired position. The elongated bandage and strip of adhesive tabs are preferably wound in a roll on a spool within a dispensing device, wherein the bandage and tabs can be withdrawn therefrom.

Abstract: A plastic sheath dimensioned to fit securely and snugly around an arm or leg cast or bandage of a wearer includes a flexible elastic band at an open first end constructed with at least one expandable trough encircling the sheath, with a stretchable band looped over the elastic band and fitted within the trough at said first end, and with the stretchable band being rollable forwardly from the opened first end of the sheath towards an opposite sealed second end from trough to trough when it is desired to remove the sheath from being worn.

Abstract: The Improved Sock is made of yarns knitted into a foot and calf, with graduated compression on an individual's foot from the foot to the calf. The yarns can include wool and alpaca fibers. A substantial proportion of wool and/or alpaca are on the inside of the sock so as to be in direct contact with the skin and wound. The Improved Sock provides absorption and wicking of inflammatory mediators, bacteria and biofilm and necrotic exudate from the foot and leg. The Improved Sock has AgNP shapes electrostatically bonded to the yarn. At least 30% of the mass of the AgNP shapes attached to the fibers have a shape selected from the group consisting of truncated triangular plates (a triangle with the corners rounded off), triangular prisms, discs and combinations of two or more of them. The Improved Sock functions as a unique wound dressing with the sock in direct contact with the wound.