Abstract: In an endoscope bending tube provided in a bending portion of an endoscope in which a first bending tube region and a second bending tube region are arranged, a slit width of a plurality of bending slits arranged in the bending tube region is set to be smaller than a slit width of a plurality of bending slits arranged in the bending tube region, a width of the bending slits on the distal end side between the neighboring bending slits is set to be smaller than a width of the slits on the proximal end side, and an interval between the neighboring bending slits of a slit row in the bending region located on the distal end side is set to be smaller than an interval between the neighboring bending slits of the slit row in the bending region located on the proximal end side.

Abstract: This overtube has a distal-end-side tubular portion that is provided with a first channel through which a manipulator is made to pass and a second channel through which an endoscope is made to pass, and that has flexibility to be driven in accordance with motions of the endoscope; and a proximal-end-side tubular portion that extends the first channel toward a proximal-end side from a proximal end of the distal-end-side tubular portion, wherein distal-end openings of the first channel and the second channel are provided at a distal end of the distal-end-side tubular portion, a proximal-end opening of the second channel is provided at the proximal end of the distal-end-side tubular portion, and a proximal-end opening of the first channel is provided at a proximal end of the proximal-end-side tubular portion.

Abstract: An endoscope includes an insertion section configured to be inserted into a subject to observe an inside of the subject. The insertion section includes a cylindrical connection member, and a hard member having a fitting portion fitted into the connection member and secured to the connection member with an adhesive applied on an outer surface of the fitting portion. At least one of the fitting portion and the connection member includes: a dam portion extending in an axial direction of the insertion section along the outer surface of the fitting portion to block the adhesive flowing along the outer surface of the fitting portion; and a storage portion continuously provided to the dam portion to partially store the adhesive blocked by the dam portion.

Abstract: An endoscope system includes a head portion, a connector portion and a CCU. The head portion includes a test signal generating portion configured to generate a first test pattern signal. The connector portion includes: a test signal generating portion configured to generate a second test pattern signal which is a same pattern signal as the first test pattern; a first comparison circuit configured to output a comparison result of comparing the first test pattern signal with the second test pattern signal; and a test signal generating portion configured to generate a third test pattern signal. The CCU includes: a test signal generating portion configured to generate a fourth test pattern signal which is a same pattern signal as the third test pattern; and a second comparison circuit configured to output a comparison result of comparing the third test pattern signal with the fourth test pattern signal.

Abstract: A family of endoscopes includes a non-zero degree endoscope (210) and a zero degree endoscope (200). Zero degree endoscope (210) includes a first image capture unit (220A) mounted in a distal portion (270A) of the zero degree endoscope with a lengthwise axis of the first image capture unit substantially parallel to a lengthwise axis of that distal portion. Non-zero degree endoscope (210) includes a second image capture unit (220B) mounted in a distal portion (270B) of the non-zero degree endoscope with a lengthwise axis of the second image capture unit intersecting a lengthwise axis of that distal portion at a non-zero angle ?. The first and second image capture units have substantially identical non-folded optical paths.

Abstract: A shape estimation device includes an input circuit, a storage circuit and an arithmetic circuit. The input circuit receives light amount information being a relationship between a wavelength and a light amount. The light amount information is acquired by using a sensor configured such that the light amount to be detected with respect to the wavelength corresponding to each of sensing parts varies in accordance with a shape of each of the sensing parts. The storage circuit stores a relationship among the shape, the wavelength and the light amount with respect to each sensing part. The arithmetic circuit calculates the shape of each sensing part, based on the light amount information, and a light amount estimation value being a relationship between the wavelength and the light amount.

Abstract: An endoscope light source apparatus includes a first light source section that emits first light, a second light source section that emits second light, and an optical path combiner that combines an optical path of the first light and an optical path of the second light. The etendue of the first light source section is smaller than the etendue of the second light source section. The optical path combiner has an optical deflection surface that deflects the second light, and has an aperture that allows the first light to pass through it within an area of the optical deflection surface. The optical path combiner deflects the second light so that a center axis of the optical path of the second light deflected by the optical deflection surface corresponds to a center axis of the optical path of the first light that has passed through the aperture.

Abstract: A flexible bar-shaped camera is applied to an intubation device and placed inside an endotracheal tube. The intubation device has a display screen. The flexible bar-shaped camera includes a main body. The endotracheal tube has a tube front end and a first curved end. The main body has a camera end, a connecting end, and a second curved end. The camera end is located at the second curved end. After the flexible bar-shaped camera is placed inside the endotracheal tube, the second curved end touches the tube front end, and the second curved end situates in the first curved end, such that the camera end is parallel to the display screen.

Abstract: The invention provides a system and method obtaining the refractive index of the cornea. According to the invention, an optical coherence tomography system with a high numerical aperture lens. In a first position, radation is focused on the front surface of the cornea; in a second position, focused on the back surface of the cornea. The distance the high numerical aperture lens moves corresponds to the thickness of the cornea. The OCT reference mirror signals in a first position correspond to the front surface of the cornea; in a second position correspond to the back surface of the cornea. The distance between the first and second positions of the reference mirror corresponds to the optical distance of the cornea. Optical distance divided by physical distance provides the refractive index. Various alternate embodiments are taught.

Abstract: An optical measurement system method for measuring a characteristic of a subject's eye use a probe beam having an infrared wavelength in the infrared spectrum to measure a refraction of the subject's eye at the infrared wavelength; capture at least two different Purkinje images at two different corresponding wavelengths from at least one surface of the lens of the subject's eye; determine from the at least two different Purkinje images a value for at least one parameter of the subject's eye; use the value of the at least one parameter to determine a customized chromatic adjustment factor for the subject's eye; and correct the measured refraction of the subject's eye at the infrared wavelength with the customized chromatic adjustment factor to determine a refraction of the subject's eye at a visible wavelength in the visible spectrum.

Abstract: A method and apparatus for measuring the topography of the corneal and scleral regions of the eye. The measurements provide surface contours that are useful in the manufacture of scleral contact lenses.

Abstract: Described herein is a light directing assembly for use in an object analysis system. The light directing assembly includes a plurality of optical relay assemblies. Each optical relay assembly includes at least one optical element configured to relay an interrogation beam from a light transmission system to an object and relay a return beam from the object to the light transmission system, the return beam being generated by reflection or back scattering of the interrogation beam by the object. Each optical relay assembly defines an interrogation angle at which the interrogation beam relayed by the optical relay assembly reaches the object, and an optical path length being the distance from the light transmission system to the object traveled by an interrogation beam via the optical relay assembly.

Abstract: A method of detecting constriction of the pupils includes: registering one or more motion illusion pattern images or one or more luminance values of the one or more motion illusion pattern images, the one or more motion illusion pattern images including a first motion illusion pattern image which had caused motion illusion to a specific user; displaying the registered one or more motion illusion pattern images or one or more motion illusion pattern images created based on the registered one or more luminance values on a display device; and determining whether the motion illusion is occurred to the specific user based on the displaying.

Abstract: A method and system for tracking eye recovery. The method includes: receiving eye data from an eyewear, wherein the eye data includes images acquired by an image capturing device in the eyewear; analyzing the eye data to determine an eye recovery status, wherein the analyzing is carried out by comparing the eye data to an initial set of eye conditions; and providing a notification of the eye recovery status.

Abstract: System and Method pertaining to the modification and integration of an existing consumer digital camera, for example, with an optical imaging module to enable point and shoot fundus photography of the eye. The auto-focus macro capability of existing consumer cameras is adapted to photograph the retina over an extended diopter range, eliminating the need for manual diopter focus adjustment. The thru-the-lens (TTL) auto-exposure flash capability of existing consumer cameras is adapted to photograph the retina with automatic flash exposure eliminating the need for manual flash adjustment. The consumer camera imaging sensor and flash are modified to perform both non-mydriatic focusing of the retina using infrared illumination and standard color flash photography of the retina without the need for additional imaging sensors or mechanical filters.

Abstract: Individuals who suffer from certain kinds of medical conditions, particularly conditions that only sporadically exhibit measurable symptoms, can feel helpless in their attempts to secure access to medical care because, at least in part, they are left to the mercy of their condition to present symptoms at the right time to allow diagnosis and treatment. Providing these individuals with ambulatory extended-wear health monitors that record ECG and physiology, preferably available over-the-counter and without health insurance preauthorization, is a first step towards addressing their needs. In addition, these individuals need a way to gain entry into the health care system once a medically-actionable medical condition has been identified. Here, the ECG and physiology is downloaded and evaluated post-monitoring against medical diagnostic criteria.

Abstract: A smart physiological monitoring system. In a first embodiment, a smart physiological monitoring system comprises a smart physiological monitoring apparatus communicably coupled with an Internet router and a mobile computing device via wireless transmission circuitry, the wireless communication circuitry of the smart physiological monitoring apparatus comprising Wi-Fi communication circuitry and Bluetooth communication circuitry. The smart physiological monitoring apparatus further comprising a sensor network, the sensor network comprising at least one physiological parameter sensor.

Abstract: An object information acquiring apparatus of the present invention includes a light source generating light having a first and a second wavelength, a conversion element receiving photoacoustic waves from an object and outputs first and second reception signals, a characteristic information acquiring unit acquiring first and second characteristic information distributions and acquiring a substance concentration distribution inside the object, a position shift acquiring unit acquiring a position shift between the first and second characteristic information distributions, and a display controlling unit displaying an image based on the substance concentration distribution and the position shift.

Abstract: Some embodiments relate to a device, method, and/or computer-readable medium storing processor-executable process steps to remove a component of a signal corresponding to ambient light in a photoplethysmographic sensor device, including capturing a first detected light signal representing an ambient light at a first time, causing a light emitter to generate a source light signal driven at a first level, capturing a second detected light signal representing the source light signal after interacting with a user's tissue plus the first detected light signal, generating a first output signal based on the second detected light signal adjusted by the first detected light signal, causing the light emitter to generate a source light signal driven at a second level, capturing a third detected light signal representing the source light signal driven at the second level after interacting with the user's skin plus the first detected light signal, and generating a second output signal based on the third detected light sig

Abstract: This disclosure describes various systems for collecting thermal measurements of regions of a user's face. Each of the systems includes a frame configured to be worn on the user's head, and one or more lightweight thermal cameras that are coupled to the frame and configured to take thermal measurements of a region of interest on the user's face. Due to their coupling to the frame, the thermal cameras remain pointed at their respective regions of interest event when the user's head performs angular movements. The thermal measurements collected by some embodiments of the systems described herein may be utilized for a variety of applications that involve detecting different types of physiological responses or medical disorders.

Abstract: A device for measuring temperature includes first and second temperature sensors enclosed in a first material having one or more material components, a contact surface for contacting a body whose temperature is to be measured, at least part of the contact surface being parallel to a lateral direction. The first and second temperature sensors are arranged at different depths from the contact surface and the net thermal conductivity across the device from the contact surface through the first and second temperature sensors is greater than the net lateral thermal conductivity of the device through the first and second temperature sensors.

Abstract: It is an object of the present invention to provide a heart rate monitor system (10) which is able to determine the resting heart rate in an effective and unobtrusive manner. In an aspect of the present invention, a heart rate monitor system (10) comprising an inactivity determining unit (320) for determining periods of inactivity (IP) of a user based on motion data (MD) detected by at least one motion sensor (200) attached to the user and a resting heart rate calculating unit (330) for calculating a resting heart rate (RHR) of the user based on heart rate data (HR) detected by at least one heart rate sensor (100) attached to the user during the periods of inactivity (IP) as determined by the inactivity determining unit (320) is provided.

Abstract: Systems and methods for detecting cardiac conditions such as events indicative of worsening heart failure are described. A system can include a sensor circuit to sense a physiological signal, transform one or more first signal portions of the physiological signal into one or more baseline values, and transform one or more second signal portions of the physiological signal into short-term values associated with respective timing information. The system can generate a cardiac condition indicator using a weighted combination of relative difference between the one or more short-term values and the one or more baseline values. The weighting can include one or more weight factors determined according to the timings of the one or more second signal portions. The system can output an indication of a progression over time of the cardiac condition indicator, or deliver therapy according to the cardiac condition indicator.

Abstract: A method for monitoring autoregulation includes, using a processor, receiving a blood pressure signal an oxygen saturation signal, and a regional oxygen saturation signal from a patient. The method also includes normalizing the regional oxygen saturation signal to correct for variation in the oxygen saturation signal based on a relationship between the oxygen saturation signal and the regional oxygen saturation signal. The method further includes determining a linear correlation between the blood pressure signal and the normalized regional oxygen saturation signal. The method still further includes providing a signal indicative of the patient's autoregulation status to an output device based on the linear correlation.

Abstract: A person support apparatus includes a frame and a support surface cooperating with the frame to support a person. The person support apparatus also has a sensor coupled to one of the frame and the support surface. The sensor detects at least one characteristic associated with the person. A controller is coupled to the sensor. In response to at least one of a condition of the frame, a condition of the support surface, a position of the person, or a condition of the person, the controller operates to control the sensor by at least one of changing a gain of the sensor and changing a manner in which a signal from the sensor is filtered. In some instances, the controller turns the sensor off.

Abstract: The invention describes an implantable pressure sensor having a housing, wherein the housing has walls and two or more pressure transfer membranes bounding an internal volume, wherein the pressure transfer membranes are not coplanar.

Abstract: Methods to identify and risk stratify disease states, cardiac structural defects, functional cardiac deficiencies induced by teratogens and other toxic agents, pathological substrates, conduction delays and defects, and ejection fraction using single channel biological data obtained from the subject. A modified Matching Pursuit (MP) algorithm may be used to find a noiseless model of the data that is sparse and does not assume periodicity of the signal. After the model is derived, various metrics and subspaces are extracted to characterize the cardiac system. In another method, space-time domain is divided into a number of regions (which is largely determined by the signal length), the density of the signal is computed in each region and input to a learning algorithm to associate them to the desired cardiac dysfunction indicator target.

Abstract: A measurement device includes an ear canal connection configured to be inserted into an ear canal, a shaft extending from the ear canal connection along an insertion direction, a biological sensor configured to be turnable about the shaft relative to the ear canal connection and a controller configured to measure the biological information based on a biometric output obtained from the biological sensor.

Abstract: An apparatus includes a wearable sensor structure that includes multiple individual sensor units placed in a row. Each individual sensor unit includes a first portion to contact a surface of skin under which arteries and/or veins are to be located, and a second portion that contacts the first portion and is configured to have a capacitance. The first and second portions are configured to create a capacitance change in response to a squeezing or bending between the first portion and a fixed part of the second portion caused by a pulse pressure and release of the pulse pressure. The apparatus includes circuitry configured to measure waveforms for the individual sensor units. Each waveform captures the capacitance change for its corresponding individual sensor unit. The apparatus includes a wireless interface configured to transmit the waveforms. A computing system is also disclosed that analyzes the waveforms and can provide alerts based thereon.

Abstract: The present invention is directed to a wearable system wherein elements of the system, including various sensors adapted to detect biometric and other data and/or to deliver drugs, are positioned proximal to, on the ear or in the ear canal of a person. In embodiments of the invention, elements of the system are positioned on the ear or in the ear canal for extended periods of time. For example, an element of the system may be positioned on the tympanic membrane of a user and left there overnight, for multiple days, months, or years. Because of the position and longevity of the system elements in the ear canal, the present invention has many advantages over prior wearable biometric and drug delivery devices.

Abstract: Provided is a technology for measuring a user's blood pressure by using light sources, in which the blood pressure measuring apparatus includes: a light emitter configured to emit one or more lights having different penetration characteristics toward a user; a light receiver configured to receive the lights that have penetrated through the user, and acquire photo-plethysmography (PPG) signals from the received lights; and a blood pressure measurer configured to measure a phase difference between the acquired PPG signals, and measure a blood pressure based on the measured phase difference.

Abstract: A wearable heart rate monitoring device includes an optical sensor configured to translate test light reflected from a wearer of the wearable heart rate monitoring device into a machine-readable heart rate signal. The wearable heart rate monitoring device also includes an elevation sensor configured to translate an elevation of the wearable heart rate monitoring device into a machine-readable elevation signal. The wearable heart rate monitoring device further includes a heart rate reporting machine configured to output an estimated heart rate based on at least the machine-readable heart rate signal and the machine-readable elevation signal.

Abstract: The present invention relates to a device, system and method for obtaining vital sign related information of a living being.

Abstract: An apparatus and a method of measuring bioinformation are provided. The apparatus for measuring bioinformation includes a first sensor configured to measure a first biosignal including arterial pulse wave information, a second sensor configured to measure a second biosignal including venous or capillary pulse wave information, and a bioinformation estimator configured to estimate bioinformation of a user based on a time delay between the first biosignal and the second biosignal.

Abstract: The present disclosure provides systems and methods for generating an electrophysiological map of a geometric structure. The system includes a computer-based model construction system configured to acquire electrical information at a plurality of diagnostic landmark points, assign a color value, based on the acquired electrical information, to each of the diagnostic landmark points, create a first 3D texture region storing floats for a weighted physiological metric, create a second 3D texture region storing floats for a total weight, for each diagnostic landmark point, additively blend the color value of the diagnostic landmark point into voxels of the first 3D texture region that are within a predetermined distance, normalize the colored voxels using the second 3D texture region to generate a normalized 3D texture map, generate the electrophysiological map from the normalized 3D texture map and a surface of the geometric structure, and display the generated electrophysiological map.

Abstract: Catheterization of the heart is carried out by inserting a probe having electrodes into a heart of a living subject, recording a bipolar electrogram and a unipolar electrogram from one of the electrodes at a location in the heart, and defining a window of interest wherein a rate of change in a potential of the bipolar electrogram exceeds a predetermined value. An annotation is established in the unipolar electrogram, wherein the annotation denotes a maximum rate of change in a potential of the unipolar electrogram within the window of interest. A quality value is assigned to the annotation, and a 3-dimensional map is generated of a portion of the heart that includes the annotation and the quality value thereof.

Abstract: We describe a method of processing an EEG and/or MEG signal to generate image data representing a 3D current distribution, J, within the brain, the method comprising: capturing a plurality of electric and/or magnetic measurements from the exterior of the head; solving an integral equation for a part of said current distribution to generate said image data representing said 3D current distribution, wherein said integral equation comprises an integral of a first function representing said part of said current distribution and of a second function (??vs (r, ?)) representing the geometry and conductivity of the head independent of said current distribution; wherein said solving comprises: modelling the head as at least two regions separated by at least one internal boundary, and solving a set of partial differential equations, one for each said internal region, each partial differential equation comprising a geometry-conductivity function (w(r, ?)) representing the geometry and conductivity of the respective regi

Abstract: Implantable medical device systems and methods configured to use a detection profile selected from among a plurality of detection profiles to define a detection threshold for identifying cardiac events, in which a close call definition is used to determine which of the plurality of detection profiles is to be chosen. Upon identifying a close call, in which an overdetection nearly occurred but did not actually take place, a relatively less sensitive detection profile is chosen.

Abstract: Single-unit EEG sensors contain multiple closely spaced dry electrodes that can hook onto skin and associated electronic circuitry such as amplifiers, A/D convertors, wireless transmitters, and a power source such as a battery. The electrodes can be separated by about 20 mm or less, and the associated circuitry can be situated within a volume defined by the multiple electrodes. The single-unit sensors hook onto the skin using a tooth surface so that a rotation of the sensor secures and electrically connects the sensor to the skin.

Abstract: A method of measuring bioelectric signals of a patient having an axis extending from the patient's head to the patient's feet includes attaching a patch to the patient's skin. The patch may include a first electrode and a second electrode spaced apart along a longitudinal axis of the patch. The patch may be attached such that the longitudinal axis of the patch is generally aligned with the axis of the patient. The method may also include attaching a third electrode to the patient's skin, and measuring bioelectric signals of the patient using the first electrode, the second electrode, and the third electrode.

Abstract: A system for the detection, recording, and analysis of EMG data attained during exercise in real-time is described. The system employs a surface EMG sensor equipped with a Bluetooth or a Wi-Fi module. The sensor transmits sEMG data via Bluetooth or Wi-Fi to a smart device, which processes this data utilizing a preloaded application and informs the user of the efficacy of exercises with key statistics in real-time. A sensor box containing the EMG sensor also contains a pre-amplification circuit, an amplification circuit, a DC-offset circuit, and a signal smoothing and amplifier circuit to maximize the reduction of extraneous noise frequently observed with conventional sEMG sensors. A proprietary mobile device application receives, interprets, records, and displays the EMG data for the user.

Abstract: A cooking apparatus includes a non-ferrous cooking vessel configured to receive food. The cooking apparatus also includes a ferrous cooking vessel cover that is configured for placement over a top of the non-ferrous cooking vessel. The cooking apparatus also includes one or more induction heating elements suspended from the ferrous cooking vessel cover, and a radiation source. The radiation source is configured to deliver electromagnetic radiation to the ferrous cooking vessel cover and the one or more induction heating elements such that the ferrous cooking vessel cover and the one or more induction heating elements are heated.

Abstract: A biological brain age is calculated by measuring a brain cortex thickness of each region in a brain MRI image of a person to be examined, and comparing the measured brain cortex thickness with normal control group information. A device for calculating the biological brain includes an image information input unit to input an MRI brain image of a person to be examined, a brain age calculation control unit to control a biological brain age calculation operation of the person to be examined based on the MRI brain image, a brain thickness measuring unit to measure a brain cortex thickness of each region in the MRI brain image, and a brain age calculating unit to match the measured brain cortex thickness with a normal range of brain thickness of each age, and calculate a biological brain age of the person to be examined.

Abstract: A system and method for collecting a set of kinematic data streams from an activity tracking system with at least one activity monitoring system that is attached to a user; segmenting at least a subset of the kinematic data streams into a set of segments according to actions of the user; generating a set of biomechanical signals from the kinematic data streams wherein a biomechanical signal characterize a biomechanical property during a segment and includes generating a first integration data set through data integration and baseline error correction across the set of segments of the normalized kinematic data stream and determining at least a first biomechanical signal that is at least partially based on the first integration data set; and applying the set of biomechanical signals.

Abstract: One example implementation detects Rh incompatibility between a mother and a baby by utilizing a light emitter to project light into the flesh of a user, a light detector to measure voltage from light in the flesh of the user caused by the projected light, and an Rh analyzer to detect Rh incompatibility between a user and a fetus within the user based on the voltage.

Abstract: An electronic sweat sensor (300) includes a plurality of porous substrates (310, 312), each porous substrate (310, 312) having an electrically conductive surface (320, 322). The porous substrates (310, 312) have a generally planar surface. The generally planar surface may be adapted to be positioned on skin (12) generally coplanar with the skin. The electronic sweat sensor (300) further includes a porous spacer (315) layer defining a gap between at least two of the porous substrates (310, 312). When an analyte flow (305), which may be from skin (12), is moving perpendicular to the planar surface and through at least one of the porous substrates (310, 312), at least one of the conductive surfaces (320, 322) provides an electrical response to the presence of the analyte flow (305).

Abstract: The concentration of an administered compound, such as a drug (D), in an organ or a bodily fluid, such as blood, is determined directly through detecting the drug (D) or its metabolites (DM) in sweat. The concentration may be determined indirectly by administering the drug (D) together with one or more tracer compounds (T, T2) or metabolites thereof (TM, T2M) or by detecting concentrations and trends of other analytes present in the body that react to the presence of the drug (D). By determining tracer concentration in sweat, the concentration of the drug (D) in blood or an organ can be determined. The tracer (T, T2) is a compound selected for ease of detection in sweat, known metabolic and solubility profiles that correspond to those of the drug (D), and safety of use. A smart transdermal delivery patch (300) is used to administer a dosage of drug to a wearer in coordination with at least one sweat sensor (324) reading conveying information about the wearer.

Abstract: Provided is a living organism information measurement device which users can easily and reliably operate. A living organism information measurement device for acquiring living organism information and generating measurement data relating to the information is provided with a device body, and a panel detachably attached to the device body. The device body comprises a control unit which executes a plurality of functions of the device body, a living organism information measurement unit which is connected to the control unit and generates the measurement data, and a first communication unit connected to the control unit. The panel comprises a second communication unit including a memory storing predetermined information. When the panel is attached to the device body, the first communication unit receives the predetermined information from the second communication unit. The control unit selects and executes a function corresponding to the received predetermined information among the plurality of functions.

Abstract: A method for sensing a physiological feature is provided. A sensing apparatus is provided for sensing the physiological feature. The sensing apparatus includes a lighting unit, a light sensing unit, and a controller. The lighting unit and a light sensing unit are located on the same side of a portion under test of a testing subject. The lighting unit transmits a white light to the portion under test. The light sensing unit senses a reflected light. And the controller executes a measurement operation for the physiological feature based on a color wavelength of the reflected light.

Abstract: A sensor can be manufactured by printing a working electrode onto a substrate using aerosol jet printing. Sensing chemistry (e.g., enzyme-based ink that including detection chemistry) also can be printed onto the working electrode using aerosol jet printing. A reference electrode also can be printed on the substrate at a position spaced along the substrate from the working electrode. In certain examples, the substrate can be positioned within a lumen of a skin piercing member of a sensor module.