Abstract: Bone graft compositions and methods are provided for promoting cellular recruitment bone regeneration. The novel bone graft includes at least one of: fluorapatite nano-crystalline coated non-ceramic hydrophilic hydroxylapatite crystals; and a combination of fluorapatite nano-crystalline coated non-ceramic hydrophilic hydroxylapatite crystals and fluorapatite nano-crystalline coated hydroxylapatite crystal clusters. Methods include treating cells at a bone defect site with the novel bone graft, wherein fluorapatite crystallites from the fluorapatite nano-crystalline coating immediately and continuously release fluorapatite to the cellular environment over the course of treating the cells. The compositions and methods promote cell differentiation, migration, and proliferation. Through the use of compositions and methods provided herein, inhibition of the migration of connective tissue and epithelial cells to bone defect sites is realized for better bone restoration by osteoblast cells.
Abstract: Waterborne aqueous-alcohol soluble protein compositions, methods of making the compositions, and applications thereof are disclosed. The dispersion compositions include protein, water, acid, and optionally an ester of a carboxylic acid. The methods of making the compositions including combining the protein, water, acid and optionally ester to form a dispersion without the benefit of alcohol. Applications include industrial and food applications, such as binders and coatings, for example paint binders or coatings for paper products and pharmaceuticals.
Abstract: The disclosure relates to medical devices coated with zein admixed with levulinic acid. The medical device may further include a therapeutic agent in contact with zein admixed with levulinic acid. Zein admixed with levulinic acid allows the therapeutic agent to be retained on the device during delivery and also controls the elution rate of the therapeutic agent following implantation. The disclosure further relates to methods of delivering a therapeutic agent on said medical devices as well as their use especially in the form of stents for prevention of restenosis.
Type:
Grant
Filed:
November 19, 2008
Date of Patent:
September 3, 2013
Assignee:
Cook Medical Technologies LLC
Inventors:
Ashley P. Lindsay, Waleska Perez-Segarra, Patrick H. Ruane, Christine Casterline
Abstract: The present invention relates to a process for producing protein microparticles in dilute organic acid solutions and in the absence of an alcohol such as ethanol. The microparticles are formed by dissolving a cereal prolamin protein in a concentrated organic acid solution with agitation and then diluting the solution with an aqueous solution. Protein microparticles having vacuoles are thus formed. The protein microparticles may be used to form powders, films, coatings, matrices, scaffolds and the like. Complete films can be formed from the protein microparticles of the invention.
Abstract: The invention relates to water-based prolamin (e.g., zein) compositions and to methods of making water-based prolamin compositions. The compositions may be used in paints, printing inks, varnishes, adhesives, glues, binders (e.g., for paper), food coatings, and the like.
Abstract: A coating composition comprising from 5-15% by weight prolamine, from 5 to 15% by weight surfactant and from 70-90% by weight water is provided along with methods of sizing substrates. Particularly preferred are compositions further comprising glyoxal or other crosslinking agents. Also provided are coating compositions comprising from 5 to 30% surfactant by weight with water and an antifoam agent and further comprising a carbohydrate The compositions are optionally applied with additional coating ingredients including carbohydrates including starches as well as binders, minerals and pigments and antifoam agents.
Type:
Application
Filed:
November 15, 2011
Publication date:
May 24, 2012
Applicant:
PENFORD PRODUCTS CO.
Inventors:
Flave Markland, John Widen, Nikola A. Nikolic
Abstract: Sheets, films, and articles of manufacture from a corn zein resin. A wet corn zein resin is formed including corn zein and a fatty acid, and the wet zein resin is cold rolled into sheets. The sheets are dried, and the dried zein resin is processed to form sheets, films, and/or articles of manufacture.
Type:
Grant
Filed:
September 22, 2003
Date of Patent:
February 1, 2005
Assignee:
The Board of Trustees of The University of Illinois
Inventors:
Graciela Wild Padua, Andrianaivo Maherisoa Rakotonirainy, Toan Thanh Ha
Abstract: Plasticized prolamine compositions and methods of preparing same are provided. The compositions can be used for making chewing gum bases, especially as biodegradable chewing gum bases. The inventive plasticizers are selected from a group of N-acyl derivatives of amino acids. The compositions are also useful for making other edible products as well as eco-friendly packaging films, coatings, adhesives, and encapsulation vehicles for medicament delivery and the like.