Abstract: A fluid dispensing device comprising a body defining a cavity and a dispensing nozzle. A fluid discharging device is housed in the cavity. The fluid discharging device has a hollow casing defining a reservoir for containing a volume of fluid and a plunger slidingly engaged within the hollow casing. The plunger has a tubular portion which is arranged to extend from a first end of the hollow casing for co-operation with the dispensing nozzle. A biasing means is interposed between a second end of the hollow casing and an end wall of the cavity to bias the hollow casing towards the dispensing nozzle. A locking means holds the biasing means in a compressed state. Upon release of the locking means, the force stored in the biasing means is applied to the hollow casing thereby causing fluid to be ejected from the reservoir into the dispensing nozzle.

Abstract: A nasal delivery device is provided for delivering substances such as liquid drugs, vaccines and the like to a nasal passage. The nasal delivery device preferably comprises a drug container such as syringe and a separable spray nozzle. The spray nozzle includes a rigid plastic cap having a spray aperture at a distal end of the nozzle for delivering the liquid substance to the nasal passage. Attachment means is provided for attaching the spray nozzle to the syringe at the time of the delivery of the liquid substance to the nasal passage. The nozzle defines a conduit that allows fluid communication from the syringe to the spray aperture. The nozzle includes an internal valve between the spray aperture and the syringe for allowing only pressurized liquid substance to flow through the conduit and the aperture so that a mist or spray is delivered through the spray aperture.

Abstract: A drug delivery device and method is disclosed which produces aerosolized particles of pharmaceutically active drug for delivery to a patient by inhalation. The device is comprised of a liquid feeding source such as a channel to which formulation is added at one end and expelled through an exit opening. The feeding channel is surrounded by a pressurized chamber into which gas is fed and out of which gas is expelled from an opening. The opening from which the gas is expelled is positioned directly in front of the flow path of liquid expelled from the feeding channel. Various parameters are adjusted so that pressurized gas surrounds liquid flowing out of the feeding channel in a manner so as to maintain a stable capillary microjet of liquid until the liquid exits the pressure chamber opening and is aerosolized. The aerosolized particles having a uniform diameter in the range of about 1 to 5 microns are inhaled into a patient's lungs and thereafter reach the patient's circulatory system.

Abstract: A fluid dispenser device having a body (1), a fluid reservoir (3) containing two half-doses, a dispensing mechanism that dispenses a half-dose of fluid upon actuation, and an energy accumulation mechanism (50, 51, 55) that accumulates energy in the hand of the user and released suddenly so that each of the half-doses is dispensed in full. The dispensing mechanism includes a dispensing member (8) mounted to slide in the reservoir (3) for dispensing the fluid, an actuating element (5) mounted to move between a rest position and an actuating position and on which the user exerts an actuating force to move the dispensing member (8) inside said reservoir (3). The actuating element is mounted to move in a direction substantially transverse to the direction in which the dispensing member (8) moves, and a dose-splitting mechanism (7, 12) dispenses a half-dose of fluid each time the dispensing mechanism is actuated.

Abstract: A dispensing apparatus for dispensing a unit dose of a pharmaceutical substance, in particular for intranasal administration, is described. The apparatus includes a nozzle unit having a safety cap thereon and an actuating device. The safety cap has legs, which can locate within the actuating device. Upon mounting the nozzle unit on the actuating device, the legs on the safety cap push down a ram in the device against the action of a spring, until the head of the ram engages over a shoulder. The ram is released by depression of a button on the device and by relative movement of two parts of the device.

Abstract: A nozzle assembly for use in atomizing and generating sprays from a fluid. The nozzle assembly includes two members, each with generally planar surfaces, that are joined together. A first set of channels is formed in the generally planar surface of a first one of the members to form, in cooperation with the generally planar surface of the second of the members, a plurality of filter passageways. A plenum chamber is formed in the first member. The plenum chamber is in fluid communication with and downstream of the plurality of filter passageways. A second set of channels is formed in the generally planar surface of the first member to form, in cooperation with the generally planar surface of the second member, a plurality of nozzle outlet passageways. These nozzle outlet passageways are in fluid communication with the plenum chamber.

Abstract: An inhaler comprises a pump 17, a drug dosing device 15 and a cyclone 1 which delivers an aerosol of powdered medicament from the drug dosing device 15 into a chamber 11 when the pump 17 is activated. The aerosol is inhaled by the user through a mouthpiece 13.

Abstract: A fluid dispenser device including a body (1), a reservoir unit (3) having a reservoir containing one dose or two half-doses of fluid, a dispensing member mounted to move axially inside the reservoir (3) between a rest position and a dispensing position, and an actuating element (5) that is mounted to move between a rest position and an actuating position. The actuating element (5) is disposed laterally, and has an end portion provided with a cam surface (6) which co-operates with the dispensing member (8) or the reservoir unit (3), the actuating element (5) being moved in a direction that is different from, and in particular substantially perpendicular to, the axial direction in which the dispensing member (8) moves relative to the reservoir.

Abstract: An aerosol medication delivery apparatus includes a holding chamber having an input end and an output end and defining an interior space. The output end comprises an orifice having a cross-sectional area of less than about 60 mm2. In one preferred embodiment, the orifice has a circular cross-section. Preferably, the orifice has a diameter of between about 2.0 mm and about 7.50 mm. In one preferred embodiment, an inhalation and exhalation valve is located at the output end. A method of using the holding chamber is also provided.

Abstract: Disclosed are methods for determining the smoothness index of the interior of a metered dose container.

Abstract: A spacer for delivering a medication spray from an inhaler includes a first conical body joined to a second conical body, forming a continuous spray conduit through first and second internal chambers of the respective first and second conical bodies. A mouthpiece is formed in the proximal end of the first conical body. A spray inlet for attachment to the inhaler is formed at the distal end of the second conical body. A plurality of air inlets are placed downstream of the medication inlet proximate to, or in, the large diameter distal end surface of the first conical body. Recirculation zones are created in the first and second chambers, to force the medication spray into a central airflow path through the spray conduit, minimizing particle deposition by contract with the walls of the spacer.

Abstract: A valve device, particularly for a breathing regulator for divers, including an inlet chamber which can be connected to a source of gas under super-atmospheric pressure, and an outlet chamber which is under a regulated pressure. A seating, which is movable under the influence of the super-atmospheric pressure and the regulated pressure, seals between the inlet chamber and the outlet chamber and has a through-passing passageway that interconnects the chambers. Also included is a valve body which is movably arranged in the seating such as to open and close the through-passing passageway in the seating. A servo element exerts on the valve body a force that depends on the position of the movable seating, so that varying force-influence on the valve body from the super-atmospheric pressure will be compensated for by a corresponding varying force from the servo element. This results in an essentially constant valve characteristic, while providing a mechanically simple solution at the same time.

Abstract: A drug delivery device and method is disclosed which produces aerosolized particles of pharmaceutically active drug for delivery to a patient by inhalation. The device is comprised of a liquid feeding source such as a channel to which formulation is added at one end and expelled through an exit opening. The feeding channel is surrounded by a pressurized chamber into which gas is fed and out of which gas is expelled from an opening. The opening from which the gas is expelled is positioned directly in front of the flow path of liquid expelled from the feeding channel. Various parameters are adjusted so that pressurized gas surrounds liquid flowing out of the feeding channel in a manner so as to maintain a stable capillary microjet of liquid until the liquid exits the pressure chamber opening and is aerosolized. The aerosolized particles having a uniform diameter in the range of about 1 to 5 microns are inhaled into a patient's lungs and thereafter reach the patient's circulatory system.

Abstract: A drug delivery device and method is disclosed which produces aerosolized particles of pharmaceutically active drug for delivery to a patient by inhalation. The device is comprised of a liquid feeding source such as a channel to which formulation is added at one end and expelled through an exit opening. The feeding channel is surrounded by a pressurized chamber into which gas is fed and out of which gas is expelled from an opening. The opening from which the gas is expelled is positioned directly in front of the flow path of liquid expelled from the feeding channel. Various parameters are adjusted so that pressurized gas surrounds liquid flowing out of the feeding channel in a manner so as to maintain a stable capillary microjet of liquid until the liquid exits the pressure chamber opening and is aerosolized. The aerosolized particles having a uniform diameter in the range of about 1 to 5 microns are inhaled into a patient's lungs and thereafter reach the patient's circulatory system.

Abstract: A cardiopulmonary resuscitation device and method that combines artificial, emergency ventilation of a patient's lungs with chest compressions on the patient's sternum area. The device includes a self-inflating bag having a top side, a bottom side, and an outlet port through which the content of the bag is forced when the top side of the bag is pushed toward the bottom side of the bag; target indicia on the self-inflating bag to indicate the proper position of the self-inflating bag on the patient's sternum area and to indicate the proper location on the self-inflating bag for applying force to the top side of the self-inflating bag; a face mask for placement over the patient's mouth and nose; and a tube extending from the outlet port of the self-inflating bag to the face mask.

Abstract: Dosages of inhaled insulin are controlled within a narrow range by controlling the total volume of air inhaled by a patient. By repeatedly delivering aerosolized insulin with the same total inhaled volume of air, the amount of insulin delivered to the patient each time is consistent. A device for delivering insulin by inhalation is disclosed which device comprises a means for measuring inhaled volume and for halting inhalation at a pre-determined point. The device also comprises an adjustable means for applying various amounts of force to a container of formulation to expel different amounts of drug from the container based on the force applied.

Abstract: A mask is provided for the inhalation of medication, such as asthmatic medication. The mask is molded of a resilient plastic or rubber material and has a central through opening and includes an open front portion adapted to receive an aerosolization chamber which receives medication from a metered dose inhaler. A sidewall expands outwardly from the open front portion and is adapted to fit sealingly on a face covering the mouth and nose. The sidewall is provided with an extension to accommodate the nose. A one-way exhalation valve is provided in the mask, preferably at the far end of the nose accommodating extension for conveying exhaled air to the outside, and preventing entrance of outside air therethrough into said mask.

Abstract: A device used with fluid canisters comprising a transparent body allowing the viewing of movement within the body having a minor and major cavity with a float indicator and float seat within the minor cavity. An inhaler top and bottom fits each end of the body forming an airtight chamber within the major and minor cavity above the float, the top having a seat to accept a canister and a nozzle aperture to accept a nozzle of the canister oriented to release fluid from the canister into the major cavity. An inlet through the minor cavity below the seat maintains pressure equal to pressure outside of the body within the minor cavity. Inhalation through a mouthpiece and one way valve reduces pressure within the major and minor cavity above the float drawing fluid through the one way valve creating a pressure difference across the float causing it to move.

Abstract: The invention features a drug delivery device which contains a cup-shaped body for enclosing a single external nare of a mammal but does not extend into the nostril of the mammal. The device is used in methods to treat pulmonary diseases. e.g., exercise intolerance, cough, and asthma-like attacks in horses and other animals.

Abstract: The invention comprises a medicinal inhaler spacer or actuator comprising a chamber having a proximal end closed by a proximal plate, a tangentially aligned inlet on the proximal end of the chamber, a tapered distal end, and an outlet extending through the proximal plate into and communicating with the chamber. Spacers of the present invention may be used to increase the respirable fraction of a medicinal aerosol inhaler. The invention also comprises medicinal aerosol inhalers and methods of delivering drug to the lung of a mammal employing these spacers.

Abstract: The present invention concerns a fluid product distributor comprising a reservoir of fluid product (1), a distribution outlet, a distribution system (2) for distributing fluid product through the distribution outlet, and an activating button (3) to activate the means of distribution. The distribution further comprises a visible reservoir the distribution outlet and the activating button (3) being located on either side of the reservoir (1), such that the reservoir visibly extends between the distribution outlet and the activating button.

Abstract: The present invention relates to an inhalation device for use with an inhaler (5) comprising a dispersion chamber (18) for fluid communication with the inhaler (5) and a suction chamber (19) in fluid communication with the dispersion chamber (18). The suction chamber (19) is constructed to enable the internal volume of the suction chamber (19) to be increased during use thereby producing a negative pressure in the dispersion chamber (18). In this way, the substance to be inhaled can be drawn from the inhaler into the dispersion chamber (18) for subsequent inhalation.

Abstract: A liquid reservoir for a nebulizer is comprised of a pair of membranes formed of resilient material and sealed about their edges to form a closed chamber between them for containing a liquid to be nebulized. When the chamber is filled with liquid and thereby expanded, the resilient membranes are distended to apply pressure to the liquid in the chamber. A discharge valve controls the discharge of liquid from the reservoir to the nebulizer under the pressure applied by the membranes. The reservoir is mounted on the nebulizer so that one of the membranes abuts a surface of the nebulizer that concavely deforms the membrane to increase the pressure applied to the liquid in the chamber to reduce or eliminate any residual volume of liquid in the chamber at the end of the discharging operation.

Abstract: A flow indicator (F) for an inhaler (I) comprises a housing (1) defining a mouthpiece (M2), an inlet (2) for connection to the product-dispensing chamber of the inhaler, a chamber (3) positioned between the inlet and the mouthpiece of the indicator, and an indicator member (4) movably mounted in the chamber in such a manner that inhalation at the mouthpiece of the indicator causes the indicator member to move within the chamber. The indicator member (4) is so mounted as to co-operate with a switch member (6, 9) associated with the housing (1) to provide an indication when inhalation is at an optimum rate for a given inhaler attached to the inlet (2).

Abstract: A portable medication delivery system enables a patient to elect slow continuous auto-administration or rapid bolus self-administration of a fluid medication. The medication delivery system has an infusion pump, which includes a fluid storage chamber and a spring-driven piston positioned in the fluid storage chamber. The fluid storage chamber is initially charged with the medication and the infusion pump automatically delivers a continuous dosage of the medication at a first flow rate over a long time from the fluid storage chamber to a treatment site in the patient. A bolus injector is positioned in series or in parallel with the infusion pump and is charged with a bolus dosage of the treatment fluid from the fluid storage chamber for alternate manual self-injection of the medication into the treatment site at a higher second flow rate for a short time.

Abstract: A drug delivery device and method is disclosed which produces aerosolized particles of pharmaceutically active drug for delivery to a patient by inhalation. The device is comprised of a liquid feeding source such as a channel to which formulation is added at one end and expelled through an exit opening. The feeding channel is surrounded by a pressurized chamber into which gas is fed and out of which gas is expelled from an opening. The opening from which the gas is expelled is positioned directly in front of the flow path of liquid expelled from the feeding channel. Various parameters are adjusted so that pressurized gas surrounds liquid flowing out of the feeding channel in a manner so as to maintain a stable capillary microjet of liquid until the liquid exits the pressure chamber opening and is aerosolized. The aerosolized particles having a uniform diameter in the range of about 1 to 5 microns are inhaled into a patient's lungs and thereafter reach the patient's circulatory system.

Abstract: A fluid dispenser device comprising a reservoir (10) containing one or more doses of fluid, a dispensing orifice (20), and a dispensing member (30), said device being characterized in that said reservoir is of the syringe type (10) having a hollow tube (11) provided with an upstream opening (12) and with a downstream opening (13), said upstream opening (12) being provided with a piston (40) which, at rest, forms a leaktight stopper, and which co-operates with an actuating rod (30) forming the dispensing member, and said downstream opening (13) being provided with an end-piece (50) firstly incorporating closure means (51) for forming a leaktight stopper at rest, and secondly adapted to define a spray profile (55) when the device is actuated.

Abstract: A breath acutated dry powder inhaler having a housing, a source of pressurized air, transfer valve which allows the release of pressurized air so as to act upon at least one dose of medicament whereupon when a user inhales through a mouthpiece it causes the transfer valve to release the pressurized air which causes the dose to be discharged through the mouthpiece to the user.

Abstract: A breath actuated inhaler for delivering medicament by inhalation, comprising a housing having a mouthpiece and defining an air flow path extending from the mouthpiece through the housing; the housing holding a replaceable canister of medicament actuatable to deliver a dose of medicament into the air flow path, wherein the housing defines an opening in the air flow path and the opening is closed by a closure element connected to and replaceable with the canister. The closure element acts as a safety feature because it is only closed when the inhaler is used with a canister to which a closure element is connected the closure element carries an indication of the type of medicament in the canister to allow the user to recognise the type of medicament. A plurality of inhalers may be provided in which each given inhaler has an opening with a different shape and has a closure element with a shape which conforms with the opening of the given inhaler but which does not conform with the openings of the other inhalers.

Abstract: An improved medical mechanical compressor nebulizer for atomizing liquid inhalation dose to achieve therapeutic effect comprises a body, an air compression device located in the body, a safety switch which is serially connected to voltage is located at the surrounding of the air compression device and an atomization device connecting to the air compression device and an output device. The atomization device is precisely and securely fastened to the air compression device by a screwing mechanism, not only for connection of air passage, but also for forming a coupled air chamber which serves as a buffer to attain more stabilized ejecting air, reduce noise and achieve improved atomization effect. Also, the above screwing design can prevent unwarranted power consumption if the apparatus is inadvertently activated by the user.

Abstract: An interactive character associated with a metered dose inhaler that includes a medication dispensing canister and a canister holder. The interactive character includes a base portion adapted to be coupled to a canister such that actuation of the canister to dispense a medication requires providing an actuating force on the base portion. An interactive element is coupled to the base portion so that it that activates in a manner that is readily perceived by humans. The interactive element is actuated by an actuating system responsive to the actuating force being applied to the base portion to actuate the canister.

Abstract: A method and apparatus for delivering a medicine to a patient via the patient's respiratory system with control and efficiency. A nebulization catheter is positioned in the patient's respiratory system so that a distal end of the nebulization catheter is in the respiratory system and a proximal end is outside the body. In a first aspect, the nebulization catheter may be used in conjunction with an endotracheal tube and preferably is removable from the endotracheal tube. The nebulization catheter conveys medicine in liquid form to the distal end at which location the medicine is nebulized by a pressurized gas or other nebulizing mechanism. The nebulized medicine is conveyed to the patient's lungs by the patient's respiration which may be assisted by a ventilator. By producing the aerosol of the liquid medicine at a location inside the patient's respiratory system, the nebulizing catheter provides for increased efficiency and control of the dosage of medicine being delivered.

Abstract: A drug dispensing system for substantially preventing addictive use of drugs. The system has multiple dispensers each containing a drug such as nasal spray. The drug in at least one of the dispensers is diluted to a first pre-selected concentration level with a diluent and the drug in at least a second one of the dispensers is diluted to a second lower pre-selected concentration level with a diluent.

Abstract: The inventions relates to a small light device (1) for inhaling medicaments using supported pressure respiration, comprising a mouthpiece (2), a reservoir (5; 12), which has a variable volume for receiving respiratory gas and which can be connected to the mouthpiece (2) and into the flow either directly or using a distributor (3), an adjustable, gas-tight closer (8) between the mouthpiece (2) and the reservoir (5; 12) and at least one connecting element (10; 17) for the medicament supply to the reservoir, (5; 12), said medicament being supplied either directly or indirectly, using a distributor (3). The reservoir (5; 12) has a wall which adjusts to its change in volume. Said wall can be expanded against a restoring force by the pressurised influx of respiratory gas, in such a way that the supported pressure respiration take place using the effect of the restoring force during inhalation of the respiratory gas which contains the medicament.

Abstract: A distribution valve for nasal spray allowing to distribute a drug inside the nasal cavities in a uniform and repeatable way is described. The distribution valve has a section of elliptical or oval shape, corresponding to the shape of the nostril and it has a distribution nozzle having elliptical or oval shape (or slot shape) in order to obtain a more uniform distribution of the medicament on the inner mucosa of the nasal cavity.

Abstract: The present invention relates to an inhaler for effectively delivering medications by inhalation through the mouth of patients, having a spacer for more effectively mixing the medication and air, and easy to operate lever and canister selection mechanisms. A preferred embodiment of the invention has a mouthpiece comprising a flexible, elastic material. A lever arm is provided that is opposed to the body of the inhaler, which allows a patient to use the entire hand to activate the metered dose inhaler canister. In a preferred embodiment a valve assembly and whistle are included in the inhaler to improve the consistency and effectiveness of delivery of medication to the lungs of a patient.

Abstract: Dosages of inhaled insulin are controlled within a narrow range by controlling the total volume of air inhaled by a patient. By repeatedly delivering aerosolized insulin with the same total inhaled volume of air, the amount of insulin delivered to the patient each time is consistent. A device for delivering insulin by inhalation is disclosed which device comprises a means for measuring inhaled volume and for halting inhalation at a pre-determined point. The device also comprises an adjustable means for applying various amounts of force to a container of formulation to expel different amounts of drug from the container based on the force applied.

Abstract: Method and apparatus for enabling a user having reduced manual dexterity and/or strength to operate an aerosol inhaler by modifying the inhaler to have a lever juxtaposed adjacent the flat end of the aerosol cannister, or inserting an inhaler into a device having a lever juxtaposed to the flat end of the aerosol cannister, the lever adapted to be moved by the user to depress the aerosol cannister and dispense medication contained in said aerosol cannister.

Abstract: A device for accurately delivering aerosolized doses of a medicament disperses a measured amount of drug in a measured volume of carrier gas and transfers the resulting aerosol to a chamber prior to inhalation by a patient. The chamber is filled efficiently with the aerosol, and inhalation by the patient draws the aerosol dose into the lungs. This is followed by the inhalation of atmospheric air that will push the initial dose well into the lung interiors. The apparatus optimally includes a dose regulator, a counter, a clock, a dose memory and a signal to indicate when a dose is ready for inhalation. Optimal chamber designs are disclosed.

Abstract: A disposable, expandable/collapsible medication inhalation apparatus for use with an MDI inhaler includes an elongated housing for receiving a plume of medication particles ejected by the MDI inhaler, a mouthpiece, and an inhalation valve disposed between the mouthpiece and the housing. A pair of foldable side sections are pressed together to expand the apparatus. An exhalation port in the mouthpiece allows exhalation through the mouthpiece. A collapsible boot adapter receives a mouthpiece of the MDI inhaler. The inhalation apparatus is constructed from a single sheet of foldable sheet material.

Abstract: A device used with fluid canisters comprising a transparent body allowing the viewing of movement within the body having a minor and major cavity with a float indicator and float seat within the minor cavity. An inhaler top and bottom fits each end of the body forming an airtight chamber within the major and minor cavity above the float, the top having a seat to accept a canister and a nozzle aperture to accept a nozzle of the canister oriented to release fluid from the canister into the major cavity. An inlet through the minor cavity below the seat maintains pressure equal to pressure outside of the body within the minor cavity. Inhalation through a mouthpiece and one way valve reduces pressure within the major and minor cavity above the float drawing fluid through the one way valve creating a pressure difference across the float causing it to move.

Abstract: A fluid dispenser device comprising a body (1), a reservoir unit (3) comprising a reservoir containing one dose or two half-doses of fluid, a dispensing member such as a piston (8) mounted to move axially inside the reservoir (3) between a rest position and a dispensing position, and an actuating element (5) that is mounted to move between a rest position and an actuating position, said fluid dispenser device being characterized in that said actuating element (5) is disposed laterally, and has an end portion provided with a cam surface (6) which cooperates with said dispensing member (8) or said reservoir unit (3), said actuating element (5) being moved in a direction that is different from, and in particular substantially perpendicular to, the axial direction in which the dispensing member (8) moves relative to the reservoir.

Abstract: A fluid can be discontinuously atomized with an atomizer of the present invention. The atomizer can include a helical spring, disk spring or gas spring, acting as a pressure spring, as an energy storage device, a cylinder, piston, two ducts and two valves. Atomization can be initiated manually by triggering a locking mechanism. The energy storage device can be disposed outside a storage container for the fluid. The energy storage device can be provided mechanical energy manually. Via the piston, the stored energy can exert pressure onto the fluid in the cylinder, which ranges from 1 MPa to 5 MPa (10 bar to 50 bar). Distribution of the droplet size in the atomized jet can be independent from the level of experience and behavior of the person actuating the atomizer, and can be adjusted in a reproducible manner. The mean droplet diameter can be smaller than about 50 micrometers. The mass flow of the fluid through the nozzle can be less than about 0.4 g/s.

Abstract: A nasal inhaler for introducing a substance to a nasal cavity of a user. The nasal inhaler comprises a chamber having an interior and an exterior, an outlet comprising an air exit passageway in flow communication with the interior of the chamber, a one-way air inlet valve in one-way flow communication with the interior of the chamber, and a dosage inlet passageway in flow communication with the interior of the chamber. A container includes a dispensing portion disposed in the dosage inlet passageway. In preferred embodiment, an adapter defines the dosage inlet passageway and is connected to the chamber. A mask also can be connected to the outlet. A method for dispensing a substance into the nasal cavity of the user comprises inserting the outlet into the nasal cavity, dispensing the substance into the chamber and inhaling through the outlet. A method for assembling a nasal inhaler assembly also is provided.

Abstract: A device for dispensing medication in an aerosol form from an MDI which is activated by a source of compressed air which is pressurized by a compression piston in associate with a cocking lever which also acts as a mouthpiece cover wherein the device automatically discharges the medication upon inhalation on the mouthpiece. The device also has a detachable component for alternative use as a press and breathe type inhaler.

Abstract: The present invention relates to pressurized metered dose inhaler (pMDI) actuators having with laser-drilled orifices of novel dimensions, and to medicinal aerosol solution formulation products comprising these actuators. In particular, the present invention relates to the optimisation of the output characteristics of drug solution formulations in hydrofluoroalkanes (HFAs) by use of pMDIs with actuators with laser-drilled orifices of specific dimensions. Moreover, the actuators of the present invention allow the use of solution formulations with a high ethanol content and a high ratio of ethanol to active ingredients and thus, the use of poorly soluble active ingredients in solution formulations and allow the use of solution formulations which are substantially free of low volatility components.

Abstract: The invention relates to an improved pharmaceutical substance as well as to an improved application device which is suitable for a more effective nasal administration of a substance.

Abstract: A respiratory nitric oxide meter includes a respiratory connector designed to be supported in contact with a subject and to pass respiratory gases as the subject breathes. A flow pathway receives and passes the respiration gases. One end of the pathway is in fluid communication with the respiratory connector, and the other end is in fluid communication with a reservoir of respiratory gases. A nitric oxide concentration sensor generates electrical signals as a function of the instantaneous fraction of nitric oxide as the respiration gases pass through the flow pathway.

Abstract: A drug delivery device and method is disclosed which produces aerosolized particles of pharmaceutically active drug for delivery to a patient by inhalation. The device is comprised of a liquid feeding source such as a channel to which formulation is added at one end and expelled through an exit opening. The feeding channel is surrounded by a pressurized chamber into which gas is fed and out of which gas is expelled from an opening. The opening from which the gas is expelled is positioned directly in front of the flow path of liquid expelled from the feeding channel. Various parameters are adjusted so that pressurized gas surrounds liquid flowing out of the feeding channel in a manner so as to maintain a stable capillary microjet of liquid until the liquid exits the pressure chamber opening and is aerosolized. The aerosolized particles having a uniform diameter in the range of about 1 to 5 microns are inhaled into a patient's lungs and thereafter reach the patient's circulatory system.

Abstract: A method of treating a systemic disease in a patient in need of such treatment is disclosed. The method comprising maintaining the inspiratory flow rate and volume of the patient to a certain value and then administering a medicament aerosol formulation to such patient.