Abstract: A dispensing device for dispensing a number of doses of medication to a patient, comprising a dispensing mechanism for dispensing the medication by actuation of the dispensing mechanism from a non-dispensing position to a dispensing position, a dose counter for counting the number of doses dispensed by said device, a first battery-less arrangement for providing power to said dose counter in response to the actuation of said dispensing mechanism, and an electronic display for displaying a dose indication, characterised in that the device includes a second battery-less arrangement for providing power to said electronic display when said dispensing mechanism is in said non-dispensing position.

Abstract: A liquid ejection device of the present invention includes an inhaling port portion, an ejection head for ejecting a liquid to be inhaled by a user through the inhaling port portion, a first sensor for detecting an action of the user relating to inhalation, a second sensor for detecting another action of the user relating to inhalation, the second sensor being different from the first sensor, and a determining portion for determining an operation of ejecting the liquid of the ejection head in response to both a first signal output from the first sensor and a second signal output from the second sensor, wherein the determining portion enables ejection of the liquid from the ejection head when both the first signal and the second signal are signals indicating inhalation intention of the user.

Abstract: Rotary metering valve (200) with a valve inlet (260), a valve outlet (270) and a rotary valve member (280) for transferring a metered dose of aerosol formulation from the inlet to the outlet, wherein the rotary valve member is provided with an inlet port (290) and an outlet port (300), both in communication with a metering conduit (310) in the rotary valve member, the rotary valve member in sequence being rotatable between at least three positions: inlet position where the inlet port is in communication with the valve inlet and aerosol formulation enters the metering conduit, metering position where both ports are closed preserving a metered volume of aerosol formulation in the metering conduit, outlet position where the outlet port is in communication with the valve outlet and the metered dose of aerosol formulation is dispensed from the valve.

Abstract: A portable universal inhaler system formed from an outer part and an inner part slidably received in the outer part. The inner part defines a compartment for receiving a medication canister and includes a universal connector for making a fluid dispensing connection to a variety of commercially available canisters. The inner and outer parts, when assembled, together form a housing that defines a chamber of sufficient volume to house a metered dose of medication. A mouthpiece or mouthpiece attachment location is provided in fluid communication with the chamber for permitting inhalation of medication from the chamber. The structure of the device makes it compact and portable, in the closed position, allows for storage of a medication canister in operative engagement with the device, and provides a convenient way to dispense medication, using a medication canister and a chamber, for inhalation by a user.

Abstract: A system and method of controlling the administration of a medical substance is disclosed. An aerosol generator is configured to aerosolize a medical substance and administer the aerosolized medical substance to a patient using a ventilator. The patient is provided with a patient control interface through which the patient initiates the administration of a dose of the aerosolized medical substance. A processor is configured to control the ventilator and the aerosol generator in response to the patient control interface such that the patient controls the administration of the aerosolized medical substance in accordance with limits on the administration of the medical substance.

Abstract: Provided herein is a metered dose inhaler for use with a pressurized aerosol container which is preferably breath-actuated. The metered dose inhaler contains a diaphragm which includes a central disk of a first, relatively high stiffness material and a peripheral ring, coupled by a flexure of a second, relatively low stiffness material.

Abstract: The present invention relates to an Breath actuated inhaler (BAI) actuator, comprising: a loading element capable of being loaded with an actuation force, a breath actuated trigger mechanism arranged to counteract the actuation force of the loading element, and to fire the actuator by releasing the actuation force of the loading element in response to an inhalation breath, and actuation locking means moveable between a locked position wherein it relieves the actuation force from the trigger mechanism setting the trigger mechanism in a neutral position, and an armed position wherein the trigger mechanism is set in an armed position.

Abstract: The invention provides a pMDI metering valve comprising at least one component which comprises a desiccant-entrained material, a pMDI closed container system containing a desiccant-entrained material, and a method of stabilising the fine particle mass (FPM) of an inhalation drug formulation emitted by a pMDI closed container system comprising providing a desiccant-entrained material inside the pMDI closed container system so as to be in contact with the formulation therein.

Abstract: In a press-type medical nebulizer and a pressing means thereof, the nebulizer includes a medicament container having an intake channel and a medical spray generator. The pressing means includes a base, a pressing element and a switching element. The base has a gas-delivering tube, a gas-releasing hole and a trough. The pressing element comprises an operating arm pivotally connected into the trough and a valve for closing the gas-releasing hole. The switching element is slidingly provided on the operating arm to be selectively engaged into the trough for fixing the operating arm. When the switching element is engaged into the trough, the switching element causes the valve to close the gas-releasing hole, so that the pressurized gas can continuously flow through the gas-delivering tube and enter the intake channel. By this arrangement, the user needs not to press the pressing means repeatedly, which is convenient and labor-saving.

Abstract: An inhaler, such as a breath-actuated metered-dose inhaler, for delivering medicament to a patient. The inhaler includes a housing for holding the medicament and having an air inlet and a medicament delivery port which together define an air flow path into which the medicament is dispensed. The air inlet includes an array of elongate apertures formed in the housing, the long sides of adjacent apertures facing each other. Each aperture is provided with a respective different opening in an outer surface of the housing. The opening of each aperture extends in two different planes such that, if at least a part of the opening is covered in one of the two different planes during inhalation by the patient, a void space is created between the cover and the aperture so as to provide an air flow path through the void space to the at least one aperture.

Abstract: The invention relates to a high-pressure chamber for preferably atomizing or injecting metered amounts of fluid, such as pharmaceutical preparations. The components of the high-pressure chamber determining the strength thereof are made of a sintered metal body having plastic regions directly attached thereto. The plastic regions allow corrosion resistance and material compatibility of the interior of the high-pressure chamber and fluids placed under pressure therein. The shape of the sintered metal body provides the entire system with the rigidity required for high-pressure operation and with directly molded connection elements prescribing the type of connection to other components. The components of the high-pressure chamber determining the strength thereof are thereby deformed or crimped to each other, so that inexpensive and quick overall assembly processes are available.

Abstract: A dose counter is provided for coupling with a metered dose inhaler. The dose counter includes a top cover that has a top forming an observation window. The top cover forms an interior space receiving therein a circuit board and an electrical cell supplying electrical power. The circuit board includes a counting circuit and a display screen that is arranged under the window. As such, in the use of the inhaler, depression of the top cover actuates the inhaler and causes the display screen to display the number of times of actuation so as to allow a user to realize the remaining number of times for use of the inhaler thereby improving safety of medication use.

Abstract: A nasal nebulizer with a main canister for receiving fluid and an insert with a fluid channel includes a contiguous pressurized air supply source. The fluid channel may be a tapered tube overlapping an air exit port in the canister. The fluid channel may also comprise a common bell housing surrounding the air exit port above a base of the insert, which rests within the canister. The insert may include an extension projecting out to the canister and a vertical groove may extend down the fluid channel to a hole in the extension, which upon use helps create a vacuum that pulls in deflected fluid. The main canister includes a convex top surface around the periphery of an opening for a reservoir that receives fluids. The top surface extends downwardly to a generally rectangular opening that connects to the pressurized air supply source.

Abstract: Disclosed is a method of regulating fluid flow for a targeted lung region. The method comprises injecting a therapeutic agent into the targeted lung region. The therapeutic agent induces a reaction in lung tissue of the targeted lung region or in a collateral pathway to the lung region to reduce collateral fluid flow into the targeted lung region. In one aspect, the method additionally comprises deploying a bronchial isolation device in the direct pathway to regulate fluid flow to the targeted lung region through the direct pathway. The therapeutic agent can comprise, for example, a sclerosing agent that induces a reaction that causes sclerosis in the lung tissue.

Abstract: A processing method and apparatus are disclosed for processing an inhaler component of a dry powder inhaler so as to remove any electrostatic charge and improve inhaler performance in drug delivery to the respiratory tract. The method includes exposing the inhaler component, while it contains an amount of medicament, to a gas in a chamber at a first predetermined pressure; exposing the inhaler component, in the chamber, to gas at a second pressure greater than the first pressure; and repeating the exposure of the inhaler component to gas at a pressure no greater than the first predetermined pressure.

Abstract: Alkaloid aminoester derivatives according to formula (I) and (VI) act as muscarinic receptor antagonists.

Abstract: Disclosed is the use of an agent (e.g., antibody fragment, antagonist, ligand, dAb monomer) that binds a target in pulmonary tissue for the manufacture of a long action or long therapeutic window formulation for local delivery to pulmonary tissue, and methods for administering an agent that binds a target in pulmonary tissue to a subject to produce a long therapeutic window in pulmonary tissue. The formulation is for, and the method comprises, administering locally to pulmonary tissue. Also disclosed is the use of antagonists of TNFR1 for the manufacture of a formulation or medicament for treating, preventing or suppressing lung inflammation or a respiratory disease, and methods of treating such diseases. Also disclosed are the use of agents a for the manufacture of a delivery device (e.g.

Abstract: A delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: at least one nosepiece unit (21) for insertion into one nasal cavity of a subject and comprising a nosepiece (25) for fitting to the respective nostril of the subject; and at least one delivery unit (23) which is operative to deliver a substance through the at least one nosepiece unit into the one nasal cavity of the subject, wherein the at least one delivery unit includes a substance supply unit (27) for delivering a substance and an actuation unit (29) which is operable to actuate the substance supply unit, either automatically or manually, in response to nasal exhalation or at least attempted nasal exhalation by the subject.

Abstract: Improved counter device (1) having a hollow casing (2) on the inside of which a mechanical type of numerator assembly (3) is housed with an activation device for the numerator assembly (3), and wherein said activation device has a rod (4) that is axially moveable in a straight line having a protrusion that is perpendicular to the rod (4) coupled in a elongated hole (7) located in a moving element (6) jointed in a fixed point that can move at an angle; said moveable element (6) being coupled at one end to a toothed wheel (8) connected to the hub of the numerator assembly (3) itself, in a such way that when the rod (4) moves, when receives a impulsion, to record a numeric count brought about by the slide of the protrusion along the mentioned elongated hole (7) in turn bringing about the angular sliding of the moveable element (6) that activates the toothed wheel of the assembly (3).

Abstract: A conjoined tube within a tube located inside a lower section of a snorkel designed to steer water droplets away from the snorkel diver's breathing path. The lower section of the snorkel has two valves. One is the scupper valve positioned at the lowest point of the inside tube. The scupper valve is a light duty valve or a low resistance one-way watertight passage intended to allow droplets of water to drain into the main reservoir. The outer tube lower section contains a reservoir for holding residual water that travels down to the bottom of the snorkel and is contained therein. During the normal clearing operation, the reservoir can be emptied and water will exit out of the lower section and into the surrounding water.

Abstract: The invention relates to use of certain quinuclidine carbonate derivatives as cough suppressants, particularly for treating patients with upper respiratory tract infections or asthma.

Abstract: The invention provides an apparatus for forming fine particles of a substance in a precipitation chamber, in which the apparatus has means to convey the fine particles from the precipitation chamber to at least one particle collection chamber, downstream of the precipitation chamber, the particle collection chamber having an inlet and an outlet separate from the inlet. The invention also provides a method of forming fine particles of a substance, the method comprising contacting a non-gaseous fluid containing the substance with a dense fluid to expand the non-gaseous fluid in a precipitation chamber, conveying a resulting mixture of fluid and the fine particles from the precipitation chamber to a collection chamber, the collection chamber having an inlet and an outlet separate from the inlet.

Abstract: A medication delivery device for delivering a medicament by inhalation, said device comprising a housing (2) defining a chamber adapted to receive a metered dose of medication from a medication dispensing device, such as a pressurised metered dose inhaler canister or a dry powder inhaler, said chamber having an outlet (4) communicating with a mouthpiece of the device whereby said metered dose of medication can be withdrawn from the chamber via the mouthpiece by inhalation by a patient, said chamber being provided with a moveable wall (5) moveable between a first position and a second position, whereby said moveable wall is arranged to move from its first position to its second position as a patient withdraws a dose of medication from the chamber by inhalation to verify complete inhalation of said dose of medication. FIG.

Abstract: A dispenser for dispensing metered dosages of a substance from a container includes a dispenser housing having a top, a bottom, and a wall defining an elongated cavity open at the top and extending along a longitudinal axis. An indicating device includes a face member defining a viewing window. The face member is snap-fitted to the dispenser housing wall. The indicating device further includes an indicator member having a surface visible through the viewing window. The surface includes dosage indicia. The indicator member is rotatable about an axis substantially perpendicular to the longitudinal axis. An indicator actuator has at least a portion disposed in the cavity. The actuator is adapted to be moved by an actuation of the container, with the actuator adapted to rotate the indicator member upon a predetermined number of actuations of the container.

Abstract: Described herein are methods and compositions for the treatment of respiratory diseases such as, for example, exercise induced pulmonary hemorrhage. The methods include the use of compositions comprising platelet enriched plasma, for example, platelet rich plasma and/or platelet poor plasma, for treatment of respiratory diseases in humans and animals, in particular, equines, by administration to the respiratory system.

Abstract: In a first aspect, the invention relates to a method for operating an aerosol inhalation device (10), comprising the steps of transporting a certain amount of an aerosol to a desired location outside said device (10) and vibrating the transported aerosol when it has reached said desired location. In a second aspect, the invention relates to an aerosol inhalation device (10) comprising a pump (1) for flowing a certain amount of an aerosol to a desired location outside the device (10), a vibrator (2) for vibrating the transported aerosol in a vibration mode and a control configured to actuate the vibrator (2) for vibrating the flowed aerosol only when it has reached said desired location.

Abstract: A nasal spray device for the delivery of a pharmaceutical formulation to the nasal cavity in metered doses. The device includes: a pressurised aerosol canister including a vial containing a pharmaceutical formulation including an active ingredient, a propellant and, optionally, a co-solvent, the aerosol canister further including a metering valve having a valve stem; and an actuator for the aerosol canister, the actuator including a stem block having a receptacle into which the valve stem of metering valve of the aerosol canister is received and axially located and being displaceable relative to the vial of the aerosol canister to actuate the metering valve of the aerosol canister, a sump extending below the receptacle, the stem block further defining a discharge orifice for the pharmaceutical formulation and a transfer channel through which a dispensed dose of the pharmaceutical formulation is able to pass from the sump to the discharge orifice.

Abstract: Ventilator circuit aerosol delivery systems used to administer medication to a patient are disclosed. In one implementation, a metered dose inhaler (“MDI”) ventilator assembly may include a housing that defines an interior space, an inhalation port that defines an inhalation passageway in communication with the interior space, an exhalation port that defines an exhalation passageway in communication with the interior space, a patient port that defines a patient passageway in communication with the interior space, and a MDI receptacle positioned on the housing and in communication with the interior space. The MDI receptacle is operative to receive a MDI container and dispense an aerosolized medication within the MID container into the interior space so that during inhalation, an inhalation flow including the aerosolized medication may flow through the inhalation port, the interior space, and the patient port.

Abstract: A delivery system includes a holding chamber with first, second and third openings, and independently moveable first, second and third flow control members. A delivery system includes a holding chamber and a flow control member including a flap pivotable from an at rest position in a direction toward an outlet of a user interface and away from an output end of the holding chamber in response to a pressure being applied thereto.

Abstract: An inhaler for delivering a metered dose of a medicament, the inhaler comprising a dispensing port (15) and one or more containers (1, 2) holding a combination of a first drug and a second drug; wherein the first drug is for treatment of a physiological condition, and the second drug is a motivational substance; the inhaler including an actuator and a metered dispenser (3) for delivery when actuated of a predetermined dose of the first and second drugs to a patient by inhalation through the dispensing port (5).

Abstract: A breath-actuated nasal delivery device, comprising: a mouthpiece through which a user in use exhales to actuate the delivery device; a nosepiece for fitting to a nostril of the user through which a substance is in use delivered; a substance supply unit actuatable to deliver a dose of a substance through the nosepiece; a loading unit operable to load the substance supply unit with an actuation force; and a release mechanism for enabling actuation of the substance supply unit in response to exhalation by the user through the mouthpiece; wherein the release mechanism comprises a locking unit which is movable: between a locking configuration in which the substance supply unit is locked in a non-actuated position when loaded by the loading unit and a release configuration in which the substance supply unit is actuatable by the loading unit, and a trigger member for releasing the locking unit from the locking configuration to the release configuration in response to exhalation by the user through the mouthpiece an

Abstract: This invention relates to a therapeutic device and method of administering precisely measured doses of a therapeutic substance via inhalation to pediatric and adult patients. More specifically, the invention relates to a therapeutic device and method of administering inhaled medication which delivers a controlled flow rate to a mouthpiece for administration of medicament to young children and adults with a diminished capacity, at a rate of about 25.8 L/minute to 30.2 L/minute.

Abstract: A dispenser includes a dispenser housing, an indicating device connected to the dispenser housing and a container removably engaged with the dispenser housing. The container and the dispenser housing remain connected as the container is moved between an engaged position and a disengaged position relative to the dispenser housing. The dispenser housing includes an upper portion pivotally connected to a lower portion.

Abstract: Described here are compositions and methods for the treatment of respiratory conditions using glucocorticosteroids delivered by a next generation nebulizer. The methods administer a therapeutic dose with nebulization time of 2 minutes or less. The faster nebulization time improves patient compliance.

Abstract: A fluid dispenser device comprising: a reservoir (1) of fluid to be dispensed; a dispenser member (2), such as a pump or a valve, mounted on said reservoir (1); and a body (3) that is suitable for receiving said reservoir (1), said body (3) being provided with a dispenser orifice and an opening (310) through which said reservoir (1) can be inserted into the body (3), said reservoir (1) being displaceable in said body (3) between a rest position and a dispensing position, said reservoir (1) being removable from said body (3); said reservoir (1) and said body (3) including respective ID means (10, 11) that make it possible to associate said reservoir (1) with said body (3).

Abstract: The present invention application relates to a pharmaceutical preparation to be administered into respiratory organs for treating or preventing inflammatory respiratory diseases, comprising a peptide which acts on formyl peptide receptors (FPRs) or receptors analogous thereto, in an amount which is effective in suppressing respiratory inflammation. The present invention application also relates to a method for treating or preventing inflammatory respiratory diseases by using the preparation, and to a kit containing the preparation. As compared with systemic administration of the peptide by injection, direct administration of the peptide to respiratory organs remarkedly improves the effect in suppressing respiratory inflammation.

Abstract: A metered dose inhaler dose counter, the counter includes: an actuator; a rotary gear wheel having a plurality of ratchet teeth; a driver for driving the rotary gear in a step-wise fashion in response to displacement of the actuator; a pawl that prevents reverse rotation of the rotary gear; and a display coupled to the rotary gear.

Abstract: Various aspects of the present invention provide for methods of manufacturing a pharmaceutical drug product, which include storing a container at a temperature greater than ambient conditions for at least about seven days and conducting release testing on the container after storing. Products manufactured by this method have a more consistent fine particle size distribution (FSD) and fine particle fraction (FPF) at ambient conditions and at accelerated stability conditions over the life of the drug product. Advantageously, such products may more reliably and regularly pass testing requirements as required for an approved drug product by regulatory authorities such as the United States Food and Drug Administration (USFDA).

Abstract: An actuator for a metered-dose inhaler is provided. The actuator comprises a housing having a mouthpiece portion and a canister receiving portion configured to receive a canister. The actuator further comprises a member disposed within the housing and defining a valve stem receptacle configured to receive a valve stem of the canister. An orifice is formed in the member, which is in fluid communication with the valve stem receptacle and extending to a face of the member opposite to the valve stem receptacle. A longitudinal axis of the orifice is aligned with a longitudinal axis of the valve stem receptacle. At least one air inlet opening is provided in an outer shell of the housing so as to be spaced from an opening for receiving the canister and a mouthpiece opening.

Abstract: An artificial cigarette, inhaler or other nebulizer device may include a housing, an air passage into the housing, a fog generator chamber within the housing connected to the air passage, a liquid source connected to the fog generating chamber, and a fog generator within the fog generating chamber for receiving liquid from the liquid source and creating an aerosol. The fog generator may be an ultrasonic nebulizer and/or a pneumatic nebulizer.

Abstract: The invention relates to an aerosol container for pharmaceutically active aerosols that are to be administered in predetermined amounts and that are supplied in the container in the form of a suspension, the suspension also comprising, in addition to a pharmaceutically active substance, at least a propellant gas. The aerosol container has a metering valve that comprises a metering chamber and a valve stem. In a first position of the valve stem, the metering chamber is in communication with the interior of the container and has been filled with a predetermined amount of the aerosol. In a second position of the valve stem, the amount of aerosol disposed in the metering chamber is released. The propellant gas is an alternative propellant gas that is free of fluorochlorohydrocarbons, preferably a propellant gas that comprises only fluorohydrocarbons, and the inner wall of the container is coated with a plastics coating.

Abstract: The invention is for a waterproof Inhaler Usage Indicator with or without a replaceable battery (6), to provide a count of the amount of drug remaining inside the canister (4) with the counter (1) still attached to the canister (4). It is not limited to inhalers alone, but any type of canister (4) that dispenses through a nozzle (24) when placed inside an housing (2) in order to count the number of displacements between the canister (4) and housing (2). The status of the drug can be checked at any time by a quick movement of the inhaler in any axis to allow the motion sensor (40, 41) to initiate the display of the amount of remaining drug uses. The counter assembly (1) is attached to the top of the canister (4) and uses the displacement between the canister (4) and housing (2) to count the number of uses.

Abstract: A method of manufacturing an atomising body for an atomising device includes the steps of providing a support element having a first layer on a first surface of the support element and a second layer on a second surface of the support element, the first layer including a first perforated membrane and the second layer comprising a process orifice, etching a cavity through the support element, the cavity forming a fluid connection from the process orifice to the perforated membrane, by providing etching substance to the process orifice. The atomising body as obtained may advantageously be applied in an atomising device or an inhaler.

Abstract: There is provided a drug dispenser device comprising a housing defining a first chamber; extending from said housing and defining a second open chamber, an outlet for insertion into a body cavity of a patient; provided to said first chamber of the housing, a discharge block defining a discharge block orifice; receivable within the first chamber for movement therewithin, a drug discharge device, said drug discharge device having a longitudinal axis and comprising a container for storing a drug formulation to be dispensed, a discharge mechanism and a discharge channel from said container, wherein said discharge channel is receivable by said discharge block to enable discharge of said drug formulation via said discharge block orifice to said outlet; provided to the housing; and at least one finger operable member moveable to apply a force directly or indirectly to the drug discharge device for movement along the longitudinal axis towards the discharge block to actuate said discharge mechanism.

Abstract: Containers for incrementally dispensing pressurized contents are described. The containers comprise a vessel suited to contain pressurized contents, a port integral with the vessel and through which pressurized contents contained in the vessel can be released from the vessel, preferably incrementally in approximately equal amounts, and a measuring device disposed in or otherwise associated with the vessel such that the quantity or amount of contents in the vessel can be measured or assessed. The measuring device senses ambient conditions in the vessel and, directly or with other components, indicates, for example, the amount of pressurized contents remaining in the vessel and displaying it to an observer. Devices for incrementally dispensing pressurized contents from such containers are also described.

Abstract: A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece for fitting to a nostril of a subject; a delivery unit comprising a substance supply unit and a nozzle unit including at least one nozzle fluidly connected to the substance supply unit for generating an aerosol spray for delivery to a nasal airway of the subject; and an aerosol interactor operable to interact with an aerosol spray as generated by the at least one nozzle.

Abstract: A product is disclosed for inverted spray dispensing of material that comprises at least some particulate matter. The dispensing end of the container is connected to a valve, which includes a valve that moves from a biased closed position to an open position to discharge the product downward through the valve, when the dispensing end of the container is directed downward. An inlet end of the valve is spaced vertically above the dispensing end of the container when the dispensing end of the container is directed downward. The inlet end of the valve or spring cup is connected to a mesh filter having a pore size at least as large as an average diameter of the solid particles. Even when the container and a layer of settled particles forms at the dispensing end of the container, valve and mesh filter are designed so that at a portion of the proximal end of the mesh filter is disposed above the layer of settled particles to prevent clogging of the mesh filter.

Abstract: A dose counter device for an inhaler that in a reliable way registers a delivered dose from a canister in the inhaler and that at the same time substantially reduces the risk of falsely registering a dose not delivered substantially avoids erroneous counting of delivered doses from the canister.

Abstract: A breath-actuated inhaler for delivery of a medicament by inhalation from a canister (2) which is compressible to deliver a dose of medicament. The inhaler comprises a housing (1) for holding a canister (2) and including a mouthpiece (5) for delivery of a dose of medicament from a canister (2) held in the housing; and an actuation mechanism (6) for compressing a canister (2) held in the housing (1) in response to inhalation at the mouthpiece (5). The housing includes two separable portions (19, 20). The first housing portion (19) mounts the actuation mechanism (6). The second housing portion (20) houses the mouthpiece (5) and a duct (24) shaped to direct an inhalation flow from the mouthpeice (5) to the first housing portion (19) for triggering the actuation mechanism (6). The duct (24) and the mouthpiece (5) are integrally formed and separable from the second housing portion (20).

Abstract: An apparatus and method for performing positive pressure (PP) therapy alone or in combination with an aerosol delivery apparatus. The positive pressure apparatus includes a positive pressure valve having a continuously variable respiratory window. The PP valve may be associated with a patient respiratory system interface alone, such as, but not limited to, a mask or mouthpiece, or in combination with an aerosol delivery apparatus.