Abstract: An inhaler with an inner housing with a pressurised reservoir of an inhalable composition. A breath operated valve is operable by a user inhaling on an inhaling end of the inhaler. A composition flow path extends from the breath operated valve to the inhaling end via which the composition is dispensed when the breath operated valve is opened. The breath operated valve is biased closed by a biasing member contacting the breath operated valve at one end. A bung in the inner housing is positioned in an opening in the inner housing to support the end of the biasing member opposite to the breath operated valve. A rigid outer housing surrounds the inner housing and supports the bung.

Abstract: The present invention provides a new inhaler device for the administration of inhalable liquids to a patient offering one or more advantages or improvements over known inhalers, particularly inhalers for the delivery of halogenated volatile liquids such as methoxyflurane for use as an analgesic.

Abstract: An inhalation therapy device includes an atomizer for atomizing a drug which is advantageously present in the form of a fluid into an atomization chamber so that an aerosol or mist is provided in the atomization chamber. The patient or user can inhale the aerosol produced by the atomizer from the atomization chamber via a mouthpiece. The ampoule is inserted into an ampoule holder holding the fluid-containing ampoule. The inhalation therapy device also includes an opening unit for opening the fluid-containing ampoule. The ampoule holder advantageously includes a first part, disposed displaceably in relation to the opening unit, thereby allowing an ampoule present in the ampoule holder to be displaced in the direction of the opening unit.

Abstract: The present invention provides a new inhaler device for the storage and administration of inhalable liquids to a patient, such as halogenated volatile liquids, particularly methoxyflurane for use as an analgesic, the device having one or more advantages or improvements over known inhalers.

Abstract: Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.

Abstract: A dosing device generating a gas flow with an active substance finely dispersed, with a first gas flow channel and with a dosing chamber that can be fitted in the area of the first gas flow channel, and a dosing chamber release mechanism with a separating element. The first gas flow channel and/or a connection between the first gas flow channel and the dosing chamber is blocked when the separating element is in a closed position. The first gas flow channel and/or the connection between the first gas flow channel and the dosing chamber is freed when the separating element is in an open position. A slide guide element can be driven by the under-pressure applied to the mouthpiece. The separating element and/or the slide guide element is provided with a slide element that influences the sliding friction properties.

Abstract: A monodose inhaler for powdered medicaments consists of a hollow substantially pipe-shaped body that has a first portion (H), for housing a capsule or cartridge of powdered medicament, defined by a wall (W) in which there are formed slots (S) as air intakes to an inner region where the powder drops, and a second portion (M) connected to the first portion (H) for delivering the medicament by means of a primary stream (F) that carries the powder from the drop region along a delivery duct (D) whose end is suitable to be placed in the patient's mouth, and it further includes a secondary duct (D?) located under the delivery duct (D) and provided with its own air intake (S?) for delivering a powderless secondary stream (F?).

Abstract: An exhalation breath-actuated nasal deliver device for and a method of delivering a substance to a nasal cavity of a subject, the delivery device comprising: a nosepiece for fitting to a nostril of a subject; a mouthpiece through which the subject in use exhales; and delivery unit, as one of a mechanical delivery pump or a nebulizer, for delivering a substance to the nosepiece; and an actuation mechanism for actuating the delivery unit in response to oral exhalation through the mouthpiece, and preferably when at least one or both of the pressure at or the flow rate through the nosepiece exceeds a predetermined threshold.

Abstract: A user inhales medicine ejected from the medicine ejecting section of an inhaler into the air flow duct of an air flow duct forming member through a hole. As the air flow duct forming member is taken off from the inhaler body, the medicine ejecting section is covered by a cap for protection. As the air flow duct forming member is fitted to the inhaler body, the cap is opened and a sensor recognizes the open state of the cap so that the air flow duct forming member is prohibited from being fitted to and taken off from the inhaler body by a claw that is secured to the air flow duct forming member. In this way, the medicine ejecting section is prevented from being damaged when the air flow duct is fitted to and taken away from the inhaler.

Abstract: The invention provides an inhaler for dispensing medicament. The inhaler comprises auxiliary energy provision means for providing auxiliary energy for aerosolizing medicament; energy release means for releasing auxiliary energy from the auxiliary energy provision means; feed means for feeding a dose of medicament, characterized in that the inhaler comprises control means for controlling a time interval between aerosolization of the medicament and a user's inhalation. The inhaler is operable, in use, to aerosolize medicament using the auxiliary energy, and harness the user's inhalation to deliver the aerosolized medicament to the user.

Abstract: Disclosed is an inhaler for administering a medicament in the form of inhalable substances, substance formulations, or substance mixtures, especially in the form of a powder as depicted in exemplary FIG. 1. Said inhaler comprises a housing (1) which is provided with an interior (18) for accommodating at least one capsule that is filled with the medicament. The housing (1) is coupled to a mouthpiece (5) while an actuator (12) encompassing at least one needle (13) is mounted so as to be movable towards the housing in order to open the capsule. The mouthpiece (5) is effectively connected to the actuator (12) in such a way that the needle (13) of the actuator (12) does not extend into the interior (18) for puncturing the capsule in an operational position of the mouthpiece (5).

Abstract: An aerosol inhalation system includes a first conduit member for delivering medication in the form of aerosol particles to a patient. The system also includes a first device in fluid communication with the first holding chamber for producing the aerosol particles and being sealingly yet releasably received within an adapter that forms an entrance into a first holding chamber. The adapter has a compressible material disposed thereon which is at least partially compressed by insertion of the first device to form the seal between the first device and the adapter, thereby creating a closed system that is therefore capable of delivering a fixed concentration of the medication to the patient due to a valve of the valve mechanism being closed when the patient inhales and the medication is delivered to the patient.

Abstract: Fluid flow regulators and fluid conservers are disclosed. An exemplary fluid conserver may be operated in one of an intermittent mode of operation and a continuous mode of operation. Further, the exemplary conserver provides at least two pulses of fluid in response to a first trigger, such as the inhalation of a patient.

Abstract: There is provided a manifold for use in a medicament dispenser device for the delivery of medicament powder from an open blister pocket of a blister pack. The manifold comprises a body, the body defining a chimney having a chimney inlet and a chimney exit for directing airflow from the chimney inlet to the chimney exit; the body further defining a chamber having a chamber inlet and a chamber exit. The chimney exit and said chamber inlet lie side-by-side each other such that when said open blister pocket of said blister pack is positioned adjacent thereto said airflow may be directed from the chimney exit to the chamber inlet via the open blister pocket to entrain said medicament powder and enable transport thereof in the airflow from the chamber inlet to said chamber outlet. The manifold is arranged such as to delay the emptying of the medicament powder from the blister pocket.

Abstract: A process and a device for dosing a pharmaceutical agent, preferably a liquid, are proposed. To achieve an enhanced dosing accuracy, a first component that is produced in batches, such as a shaped seal, is combined with a second component, such as a guide pipe selected from a suitable group guide pipes, wherein the suitable group of second components is selected based on at least one decisively significant value of the respective batch first components and is distinguished by an essential value of the second component which will optimize the sealing between the first and second components.

Abstract: A sound dampening apparatus to be disposed in pneumatic connection with a respiratory support system. The respiratory support system may comprise a source of medical gas, a plurality of pneumatic connections and a patient interface. The sound dampening apparatus comprises an inlet, an outlet, and an outer case which forms a sound dampening chamber. As the medical gas flows through the sound dampening apparatus, the noise energy associated with the flow of medical gas is reduced.

Abstract: A nebulizer and cartridge structure thereof for use in a nebulization apparatus comprises a first cartridge accommodation space and a second cartridge accommodation space. The first cartridge accommodation space includes at least one connection bottom, and the second cartridge accommodation space includes at least one connection side. Moreover, the second cartridge accommodation space is disposed under a lower connection position of the first cartridge accommodation space. The connection bottom is connected to the connection side to form an included angle that can be a lead angle. The lead angle further includes a fillet angle or a chamfering angle. Accordingly, the nebulizer and the cartridge structure can efficiently reduce the residues of liquid medicament.

Abstract: The present invention relates to a nasal delivery device for and a method of delivering a substance, in particular one of a liquid, as a suspension or solution, or a powder containing a medicament, especially systemic or topical pharmaceuticals, or a vaccine to the nasal airway of a subject.

Abstract: A device for delivering a drug by inhalation is disclosed. The device includes a body defining an interior flow-through chamber having upstream and downstream chamber openings, and a drug supply unit contained within the chamber for producing, upon actuation, a heated drug vapor in a condensation region of the chamber. Gas drawn through the chamber region at a selected gas-flow rate is effective to form drug condensation particles from the drug vapor having a selected MMAD between 0.02 and 0.1 MMAD or between 1 and 3.5 ?m. A gas-flow control valve disposed upstream of the unit functions to limit gas-flow rate through the condensation region to the selected gas-flow rate. An actuation switch in the device activates the drug-supply unit, such that the drug-supply unit can be controlled to produce vapor when the gas-flow rate through the chamber is at the selected flow rate.

Abstract: According to one aspect of the present invention, an aerosol inhalation system includes a first conduit member for delivering medication in the form of aerosol particles to a patient. The system also includes a first device in fluid communication with the first holding chamber for producing the aerosol particles and being sealingly yet releasably received within an adapter that forms an entrance into a first holding chamber. The adapter has a compressible material disposed thereon which is at least partially compressed by insertion of the first device to form the seal between the first device and the adapter, thereby creating a closed system that is therefore capable of delivering a fixed concentration of the medication to the patient due to a valve of the valve mechanism being closed when the patient inhales and the medication is delivered to the patient.

Abstract: A ventilator circuit for use in administering medication to a patient includes a chamber housing defining an interior space and having an input end and an output end and a one-way inhalation valve positioned upstream of the interior space. The one-way inhalation valve is operative to permit a flow of medication into the interior space of the chamber housing. An inhalation conduit communicates with the output end of the chamber and is adapted to transmit the medication to the patient. An exhaust conduit is connected to the inhalation conduit and a one-way exhaust valve is located in the exhaust conduit. The one-way exhaust valve is adapted to prevent a backflow of gas from the exhaust conduit into the inhalation conduit. A method of administering a medication to a patient is also provided.

Abstract: A drug transfer system is adapted to transfer a powdered drug into a patient via inhalation. The drug transfer system includes a drug container or packet that removably inserts into an inhaler device. As the patient inhales from the inhaler device, the drug flows from the container, through the inhaler device, and into the patient's respiratory system. The system is adapted for ease of use without requiring the user to perform any cumbersome manipulations of the drug packet during insertion into the inhaler or during inhalation of the drug.

Abstract: A dry powder inhaler (1) is to be made available, with which a particle size and particle size distribution preferred for inhalation are to be achieved and by means of which as high a line particle fraction as possible is to be realized. This is achieved by means of a dry powder inhaler (1 ) that is characterized in that provided in the inhaler (1) is a nozzle (10) through which the aerosol (9) flows before leaving the inhaler (1).

Abstract: A breath actuated dry powder inhaler, comprising a substantially disc shaped air circulation chamber for de-agglomeration of entrained powdered medicament using the energy of the inspiratory air stream. The chamber has a substantially circular or polygonal sidewall extending about a central axis between top and bottom walls of the chamber so that the height of the chamber is smaller than its diameter. A plurality of air supply channels disposed about the circumference of the chamber, which channels extend from joint or separate air inlets and which channels enter the chamber substantially tangentially to its sidewall. At least one of the supply channels extends through a powder dose supply region of the inhaler. The chamber further comprises an air outlet axially extending from a discharge opening in the centre of the top or bottom wall of the chamber and connects to a discharge channel that extends to a mouthpiece.

Abstract: An inhalation aid to be used in connection with an aerosol dispenser. The inhalation aid includes a chamber designed with an opening for connection to an aerosol dispenser and an opening including a mouthpiece for drawing the aerosol. The chamber is designed with a variable volume. The chamber is delimited by a conically tapering expansion bellows made of a continuous, elastic material, whereby a simple and tight construction of the inhalation aid is obtainable.

Abstract: A gas delivery system and a method of delivering gas are disclosed. In one such system there is a housing and a displaceable partition. The housing may be divided by the partition into a respirator side and a patient side. The partition may have one or more holes extending through the partition to allow gas to move from one side of the partition to the other side of the partition.

Abstract: The present invention relates to a personal use assistive breathing device wherein a can adaptor or bottle mounting member is secured to a bottle canister containing a pressurized gas. A mouth piece member retains an action knob positioned for actuating a stem valve on the bottle canister upon a rotation. During use the action knob is spaced away from the mouthpiece and air passages entrain ambient atmospheric air with the escaping pressurized gas. The action knob may be retained in the in-use position without continual pressure allowing hands-free use. During storage, the action knob is spaced in contact with the mouthpiece prohibiting unintended gas release and enabling ready handling without risk of gas-loss.

Abstract: According to one aspect of the present invention, an aerosol inhalation system includes a first conduit member for delivering medication in the form of aerosol particles to a patient. The system includes a first holding chamber for holding the aerosol particles prior to deliver to the first conduit member and a valve mechanism associated with the first conduit member. The system also includes a first device in fluid communication with the first holding chamber for producing the aerosol particles and being sealingly yet releasably received within an adapter that forms an entrance into the first holding chamber. The adapter has a compressible material disposed thereon which is at least partially compressed by insertion of the first device to form the seal between the first device and the adapter.

Abstract: A pressure-assisted breathing system is provided that comprises: a pressure-generating circuit for maintaining a positive pressure within the system; a patient interface device coupled to a patient's respiratory system; a respiratory circuit for providing gas communication between the pressure-generating circuit and the patient interface device; means for introducing aerosol particles into the gas flow in the respiratory circuit; and means for discontinuing the introduction of aerosol particles into said respiratory circuit gas flow when the patient exhales. In one embodiment, a flow sensor is disposed in an auxiliary circuit in fluid communication with the respiratory circuit and electronically coupled with a nebulizer. The flow sensor is adapted to detect changes in the volumetric flow rate of gas in the auxiliary circuit when the patient exhales and stops exhaling and sends corresponding electronic signals to the nebulizer to turn off and turn on, respectively.

Abstract: An improved humidifier assembly includes a tubing and a one-way valve for equalizing pressure between gas space of a water supply container and gas space of a humidifier vessel.

Abstract: A self-contained system which converts nitrous oxide to a breathable gas mixture of nitrogen and oxygen. In the preferred embodiment of the present invention, a portable system is disclosed wherein liquefied nitrous oxide is converted to a breathable gas mixture of nitrogen and oxygen. The decomposition occurs over a catalyst bed which is all contained in a small reactor. The invention is useful for underwater, fire fighting and outer space applications.

Abstract: Formulations, methods and devices for producing formulations and methods for nebulizer delivery of formulations of water-insoluble drugs are provided. Also provided are methods for minimizing wastage of drugs administered by nebulizer, and for the achievement of quantitative dosing with diluent from a mass marketed formulations, which because of the mass market is much less costly per dose than formulations manufactured specifically for much lower volume medical use.

Abstract: A cool air inhaler for use in treating croup, having a body having at least one side wall and a bottom wall forming an enclosed space open at an upper portion of the body wherein the upper portion of the body is adapted to generally conform to contours of a lower part of a patient face. An air chamber is formed in an upper part of the body and has an exhaust vent for exhausting the patient's exhaled air to an exterior space while an ice reservoir is formed in a lower part of the body to contain ice and meltwater from the ice and an air passage is connected from the exterior space and passing through the ice reservoir to conduct air to the air chamber.

Abstract: The invention relates to an aerosol generator that comprises an oscillating membrane that is provided with openings. The aerosol generator is further characterized in that the liquid container is impinged upon with negative pressure by displacing a sealing element using a slidable sleeve and a rotary sleeve.

Abstract: A flow indicator (F) for an inhaler (I) comprises a housing (1) defining a mouthpiece (M2), an inlet (2) for connection to the product-dispensing chamber of the inhaler, a chamber (3) positioned between the inlet and the mouthpiece of the indicator, and an indicator member (4) movably mounted in the chamber in such a manner that inhalation at the mouthpiece of the indicator causes the indicator member to move within the chamber. The indicator member (4) is so mounted as to co-operate with a switch member (6, 9) associated with the housing (1) to provide an indication when inhalation is at an optimum rate for a given inhaler attached to the inlet (2).

Abstract: An implantable flow control element is provided which prevents air from entering an isolated portion of a patient's lung. The element may permit air to escape from the isolated portion so that the element acts like a valve. Systems for implanting pulmonary devices are also provided.

Abstract: A monitoring process for the reliable metering of different gaseous anesthetics uses a gaseous anesthetic monitor designed as only a single-channel monitor for determining the concentration of only one gaseous anesthetic. The process also uses an associated gaseous anesthetic metering means.

Abstract: A patient ventilator system has a high-frequency oscillation ventilator connectable to a patient circuit and operable to induce oscillations within gas in the circuit at a predetermined high-frequency and a gas supply connectable to the patient circuit for supplying breathing gas thereto. A detection device is also included within the ventilator system and is adapted to monitor during the operation of the high-frequency oscillator ventilator, gas pressure and/or gas flow to detect a variation therein not derived from the induced high-frequency oscillations and to output a trigger signal dependent on the detected variation indicating a spontaneous breathing effort. The gas supply is operable on receipt of the trigger signal to supply breathing gas into the circuit at a level to assist the spontaneous breathing effort.

Abstract: A device for flow rate limitation at low differential pressures, particularly for limiting the volumetric inhalation flow during inhalation of therapeutic aerosols, consists of a housing 11 including an aspiration orifice 14, an inhalation orifice 15 and a flow passage 23 disposed therebetween. The flow passage has a flat elongate cross-section with flexible large-area walls 18, 20 having a cross-sectional area adapted to be reduced, as a function of the differential pressure prevailing between the inhalation orifice and the aspiration orifice, as well as of the flexibility of the material of the walls, to a size appropriate for a predetermined volumetric maximum inhalation flow.

Abstract: A dry powder delivery system and method for use, the system having an elongated tube containing a matrix having a measured amount of dry particles of a therapeutic compound and a porous element having a desiccant therein. The porous element with the desiccant can be combined with the powder-containing matrix or it can be two separate elements. The pressure drop induced by inhalation of the user causes air to flow through the tube and into contact with the particles of dry powder for discharging the particles for inhalation by the user.

Abstract: A nebulizer has structure for determining the duration of a pulse of atomization during inspiration, the determination structure including components for measuring the tidal volume of a patient, measuring the duration of inspiration, for storing estimates of the volume of a patient's upper airway, and for calculating the duration of the pulse. The duration of the pulse is calculated on the basis of the tidal volume, the duration of inspiration, and the stored estimated volume of patient's upper airway.

Abstract: An inhaler device and a method in which powder for inhalation is jetted off a prepared device surface containing a defined pre-metered quantity of finely divided powder. The jetting function is obtained by a directed air stream pushing or cutting free a medical powder applied to a carrier surface and by creating a stream of air dispersing the powder into inspiratory air at the moment it is being inhaled. The inhaler device includes active (air permeable) porous walls for preventing finely divided powder from sticking to the inner faces of the inhaler device by creating a pressure gradient across the active wall, thus forcing a small flow of air through the active wall thereby keeping the powder from sticking to the inner faces.

Abstract: The present invention relates to a spacer for children primarily intended to be used in conjunction with a metered dose inhaler (MDI), said spacer having a generally oblong shape and being rotationally symmetrical around a central, longitudinal axis and being provided with an opening at each end located centrally in said axis for connection of an meterd dose inhaler respectively of a mouth-piece or similar. The spacer has a small total volume which is in the range between 50 and 400 ml, and the material in the spacer has a surface resitivity which is lower than 109 Ohm, preferably lower than 106 Ohm.

Abstract: A self-contained system which converts nitrous oxide to a breathable gas mixture of nitrogen and oxygen. In the preferred embodiment of the present invention, a portable system is disclosed wherein liquefied nitrous oxide is converted to a breathable gas mixture of nitrogen and oxygen. The decomposition occurs over a catalyst bed which is all contained in a small reactor. The invention is useful for underwater, fire fighting and outer space applications.

Abstract: An inhalant medicator comprises a medicator body formed at one axial end with a capsule housing hole and at another axial end with an inhalant port, an inflow air passageway having an axial inflow passage extending in an axial direction of the medicator body and a first pin insertion hole extending in a radial direction of the medicator body for communicating the capsule housing hole with the atmosphere, an outflow air passageway having an outflow passage extending in the axial direction of the medicator body and a second pin insertion hole extending in the radial direction of the medicator body for communicating the capsule housing hole with the inhalant port, and a boring tool having pins insertable toward a capsule through the first and second insertion holes for pricking holes in the capsule accommodated in the capsule housing hole with the pins.

Abstract: A vaporizer for vaporizing a liquid anaesthetic has an inlet for a carrier gas, an outlet for the carrier gas and vaporized anaesthetic, a flow channel connecting the inlet to the outlet, a chamber for liquid anaesthetic, a first connection between the flow channel and the chamber, a second connection between the flow channel and the chamber downstream from the first connection and a throttle in the flow channel between the first connection and the second connection. The second connection has a conduit, one end of which is immersed in the liquid anaesthetic, and a valve connected to the other end of the conduit so as to increase safety, prevent leakage and erroneous dispensing and allow the use of liquid anaesthetics with a low boiling point. The valve is devised to open when there is a predetermined drop in pressure across the throttle, allowing liquid anaesthetic to be dispensed into the flow channel.

Abstract: An adjustable gas flow regulator device primarily for use in medical care, said device comprising a two-part body (8/25) having a high pressure gas inlet connector (1) and a gas outlet connector (16) mounted thereon. Mounted within the body is a conventional regulator comprising a piston (9) axially movable in a stepped bore (46/47). Mounted between the output of the regulator and the outer connector (16) is a flow selector device comprising a flow selecting member (13) rotatable by means of a knob (31). The flow selecting member (13) is formed with a plurality of radially extending bores (54) in the outer part of each of which is fitted a setting plug which may be externally adjustable by a tool (not shown).