Abstract: There is provided a a respiratory gas delivery and sampling system, a gas sampling system, a gas sampling interface and a gas sampling tip that may be used to sample exhaled and/or expired gases from a patient, particularly from a patient who is apnoeic and/or who is receiving high flow respiratory therapy. The gas sampling system comprises a respiratory gas monitor in fluid communication with the gas sampling interface, which comprises the gas sampling tip of the invention. The gas sampling interface comprises a gas sampling conduit and the gas sampling tip is located at a free end of the conduit. The gas sampling interface may be configured to allow the gas sampling tip to be selectively positioned at or in the mouth or a nare of the patient's nose.

Abstract: A patient interface includes a frame, an inflatable seal, and a deformable insert. The frame includes an outer portion, an inner portion, and an opening extending therebetween. The inflatable seal is secured to the inner portion of the frame. The inflatable seal defines an internal volume and has at least one aperture. The deformable insert includes an outer surface, an inner surface and a passageway extending therebetween. The deformable insert is positioned within the internal volume of the seal and aligned with at least a portion of the frame inner portion. The passageway is aligned with the frame opening to define a gas flow path from the frame outer portion to the at least one aperture of the seal.

Abstract: The present invention discloses a respiratory mask to connect a user and a breathing tube for receiving a first gas and releasing a second gas, so as to provide an user's respiratory system to exchange gas. It comprises a main part, an air chamber exchange part, an insert and a clamping part. The main part provides a first, second, and third openings that are communicated each other. The first opening connects to the breathing tube to receive the first gas from the breathing tube. The air chamber exchange part provides an exhaust assembly to relieve pressure according to an internal air pressure of the air chamber exchange part. The insert connects to the user's nose so as to direct the first gas to the user or direct the second gas from the user to the air chamber exchange part. The clamping part connects to the user's mouth.

Abstract: In one aspect, the disclosure provides apparatuses for and related methods of delivering inhalation airstreams of different temperatures to the nostrils of a subject. Certain embodiments provide apparatuses for and related methods of alternately delivering inhalation airstreams of different temperatures to the respective nostrils of a subject.

Abstract: A breathing gases supply apparatus 1 can comprise a blower 103/105 and breathing circuit for delivering breathing gases to a patient. The apparatus also can comprise a first controller 109, the controller 109 configured to receive input from at least one sensor 110-112 indicative of patient breathing, and a transmitter 201 configured to communicate with the controller 109 and transmit control signals to an electronic apparatus 203. The controller 109 can be configured to determine sleep in a patient based on the occurrence of a breathing pattern indicative of sleep, detected from the input received from the sensor 110-112 and upon determining sleep, operate the transmitter 201 to send a control signal to control an electronic apparatus 203.

Abstract: Headgear, comprising at least one strap; and at least one rigidizer, the headgear being arranged to position one of the at least one strap and one of the at least one rigidizer, with regard to one another such that the rigidizer imparts a desired shape to at least a portion of the strap while allowing said portion of the strap to move relative to the rigidizer.

Abstract: The invention relates to a respiratory system comprising a first patient interface for delivery of a first flow of gases to a patient, a second patient interface for delivery of a second flow of gases to the patient, and a device and/or sensing arrangement that is configure to facilitate a switching of the system between a first respiratory mode where the device allowing delivery of the first flow of gases to an outlet of the first patient interface when the second patient interface is absent from the patient, and a second respiratory mode where the device reducing or stopping delivery of the first flow of gases to the outlet of the first patient interface when the second patient interface is located together with the first patient interface upon the patient.

Abstract: A system for reducing airway obstructions of a patient may include a ventilator, a control unit, a gas delivery circuit with a proximal end in fluid communication with the ventilator and a distal end in fluid communication with a nasal interface, and a nasal interface. The nasal interface may include at least one jet nozzle, and at least one spontaneous respiration sensor in communication with the control unit for detecting a respiration effort pattern and a need for supporting airway patency. The system may be open to ambient. The control unit may determine more than one gas output velocities. The more than one gas output velocities may be synchronized with different parts of a spontaneous breath effort cycle, and a gas output velocity may be determined by a need for supporting airway patency.

Abstract: A gas delivery conduit adapted for fluidly connecting to a respiratory gases delivery system in a high flow therapy system. In one embodiment, a nasal cannula includes a base portion defining a first therapeutic gas passageway, a nozzle disposed adjacent said base portion and defining a second therapeutic gas passageway, the first passageway being in gaseous communication with the second passageway and a conduit configured to facilitate sensing that has an inlet side that is independent of and axially spaced apart from an outlet side of the nozzle. The conduit inlet side can extend beyond the nozzle outlet side of the nasal cannula. Additionally, the nasal cannula has a feature adapted to prevent one of the conduit and the nozzle from creating a seal with a user's nare and a feature adapted to prevent one of the conduit and the nozzle from creating a seal with a user's nare.

Abstract: A respiratory assembly is provided. The assembly includes at least one post having a nasal engaging portion on about a first end thereof for delivering treatment gases to the nasal cavity of a patient. A pair of tubes capable of receiving gas from a hose or fluid source are selectively engaged with the pair of posts for delivering treatment gases from the inlet through the receptacle and into the nasal cavity of the patient. A splitter may be positioned between the hose or fluid source and the pair of tubes. Ball and socket joints may provide enhanced flexibility of the assembly while in use.

Abstract: This disclosure relates to a control system for a portable oxygen concentrator (POC). Specifically, this disclosure relates to a method and a system configured for use with an oxygen delivery system that includes nasal fitting which does not include nostril prongs. Because the nasal fitting does not include nostril prongs, user comfort is dramatically increased relative to prior designs. That said, because the fitting is free of nostril prongs, changes in pressure associated with the user's breathing register less than in oxygen delivery systems with traditional fittings (i.e., those that include nostril prongs). As such, the method and system of this disclosure is configured to associate relatively small changes in pressure with a breathing cycle of a user, thereby permitting effective and efficient POC operation.

Abstract: Nasal cannula assemblies for providing respiratory therapy to patients are provided. A nasal cannula assembly can include a cannula, an optional manifold which may be removable, a gas supply tube, and a securement mechanism. Securement mechanisms can include headgear straps, cheek pads, or an adhesive nose strip. A nasal cannula assembly can also include a lanyard, lanyard clip, and/or lanyard connector to help support the weight of a main gas delivery conduit.

Abstract: A patient interface device is includes a cushion and a frame assembly coupled to the cushion, the frame assembly including a main frame member and a stiffening structure coupled to the main frame member, the stiffening structure having a main arm, a first Y-portion coupled to a first end of the main arm having first and second front branches extending at upward and downward angles, respectively, from the first end of the main arm, and a second Y-portion coupled to a second end of the main arm having first and second rear branches extending at upward and downward angles, respectively, from the second end of the main arm.

Abstract: A nasal spray formulation and a method of using a locally acting sodium channel blocker to treat pain is disclosed, wherein the nasal spray formulation comprises from about 5% to about 30% w/v of a locally active sodium channel blocker, from about 0.25% to about 5% w/v of a buffering agent, and from about 5 to about 99% w/v of a pharmaceutically acceptable carrier for nasal administration. The nasal spray formulation is preferably contained in a mechanical multi-dose pump which sprays a unit dose of the nasal spray formulation with a wide plume and small droplet size, such that the unit dose is administered by actuating the mechanical multi-dose spray pump device and spraying a volume of the nasal spray formulation into each nostril of a human subject. Preferably, the nasal spray formulation does not include a preservative.

Abstract: FIGS. 1-16D & 66A-92D disclose a large variety of methods of forming the headgear for use in combination with a breathing apparatus comprising a unitary plastic core within textile casings. In some configurations, the plastic core material penetrates or bursts-through the textile casing of the straps. Some configurations include over moulding, alignment posts, T-joints and joint housings with injection aperture. FIGS. 17-65 & 93A-94C disclose a large variety of different headgear arrangements including top strap, front strap, rear strap and pairs of straps extending from the mask above and below the ear to meet behind the ear. FIGS. 95-121B disclose a large variety of connectors connecting the headgear assembly to the mask assembly where the headgear, mask and connector form a closed loop the connector is disengaged with the mask assembly.

Abstract: An adaptive gas mixture controller system. A pulse oximeter interface receives pulse oximeter data. A gas blender interface communicates with a separate externally connected gas blender. A processor receives pulse oximeter data via the pulse oximeter interface and outputs data to the gas blender interface for adaptive feedback control of the gas mixture based upon the SpO2 level signals from the pulse oximeter interface. When the processor receives data from the gas blender indicating that the gas mixture has been manually changed, enters a manual override mode and halts sending adaptive feedback control signals to the gas blender. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.

Abstract: This disclosure provides an endotracheal tube with a tip suitable for traversing the laryngeal inlet and with a guiding channel having a proximal opening adjacent a proximal end portion and a distal opening adjacent to a tip, wherein the guiding channel is adjacent a sidewall of the main lumen of the tube, which allows more accurate wire-guided intubation of a patient, a method and a kit relating to the same.

Abstract: A system includes a control unit configured to be worn by a subject, and having a wireless transceiver configured to receive and transmit signals and a processor coupled to a memory, at least one respiratory volume sensor mountable to the chest or abdomen of the subject and at least one secondary sensor mountable relative to the subject. The respiratory volume sensor is configured to operably generate one or more volumetric signals representative of a respiratory volume of the subject and communicate the one or more volumetric signals to the wireless transceiver of the control unit. The at least one secondary sensor is configured to operably generate one or more secondary signals and representative of at least one of a physiological, a cardiopulmonary or a metabolic condition of the subject, and communicate the one or more secondary signals to the wireless transceiver of the control unit.

Abstract: A high flow nasal therapy system (1) has a gas supply (2), a nebulizer (12), and a nasal interface (7). There are two branches (11, 10) and a valve (6) linked with the controller, the branches including a first branch (11) for delivery of aerosol and a second branch (10) for delivery of non-aerosolized gas. The controller controls delivery into the branches (11, 10), in which flow is unidirectional in the first and second branches, from the gas supply towards the nasal interface. The first branch (11) includes the nebulizer (12) and a line configured to store a bolus of aerosol during flow through the second branch (10). The valve (6) comprises a Y-junction between the gas inlet on one side and the branches on the other side.

Abstract: There is provided a user interface comprising: a. a mask body; b. a sealing cushion connected to the mask body and configured to seal around a patient's nose and/or mouth; wherein the mask body and sealing cushion together define an interior chamber of the user interface; c. a breathing gas delivery inlet provided in the mask body and configured to receive a breathing gas flow from a gas source; and d. at least one non-sealing nasal prong in the interior chamber. The user interface further comprising a breathing gas flow director configured to split the breathing gas flow into two flow paths such that a portion of the breathing gas flow is delivered along a first flow path from the inlet into the interior chamber to pressurise the interior chamber, and such that a portion of the breathing gas flow is delivered along a second flow path from the inlet through the nasal prong.

Abstract: A circuit connector for a humidification system, the system comprising a base unit configured to be engaged by a humidification chamber. The circuit connector comprises an inlet to fluidly connect to an outlet of the humidification chamber to receive humidified gases therefrom, an outlet to sealably connect to or integral with a conduit for directing the humidified gases to a user, and an electrical terminal for electrically coupling the circuit connector to an electrical terminal associated with the base unit. The circuit connector may be releasably and lockably connectable to the outlet of the humidification chamber and/or orientation features may control orientation of component parts of the system as they are assembled.

Abstract: A cushion for use in providing a regimen of respiratory therapy to a patient includes a base that defines a main cavity therein an aperture for receiving a flow of breathing gas. A pair of nasal pillows each extend from the base, each having a cone-shaped head that tapers inward and upward from a base portion, that extends directly from the base, to a top opening. Each head is formed to engage an inner portion of a nare of the patient. Each head defines a passage extending between the main cavity and the top opening for further conveying the flow of breathing gas from the main cavity to a nasal passage of the patient. Each base portion includes an inner edge positioned near the center of the cushion that merges with the hollow base and an opposite outer edge spaced upward from an outer surface of the hollow base.

Abstract: The present invention discloses a patient interface having an adaptive system, a respiratory mask and a cushion module adapted with the adaptive system. The adaptive system includes a forehead pressure diffusing portion, a cheek buffering portion and a connecting portion. The forehead pressure diffusing portion is disposed in a frame module. The cheek buffering portion is disposed in a cushion module. The connecting portion is positioned between the forehead pressure diffusing portion and the cheek buffering portion. The connecting portion is configured to transmit pressure between the forehead pressure diffusing portion and the cheek buffering portion. Thus, when a user wears a mask or other devices with the adaptive system, a force received by the face of the user could be automatically and appropriately distributed, further improving comfort of the wearer.

Abstract: A respiratory mask can have a frame supporting a sealing arrangement. Various features of the frame and sealing arrangement can improve comfort and reduce the occurrence of pressure sores. The frame can include cheek supports that have a large surface area configured to spread loads over a greater area of the patient's face and therefore reduce the forces applied to the face and the occurrence of point loads. The seal can have a main body that includes a spring with a silicone skin, wherein the spring applies a substantially constant force to the face and/or nares of the patient.

Abstract: A patient interface can have a frame supporting a sealing member. Various features of the sealing member can improve comfort and sealing performance in the context of forming seals with the nares of a user, as well as contact with other facial surfaces. The sealing member can include convex portions, concave portions and thickness variations for providing various sealing, comfort, and deformability effects.

Abstract: Aspects of the present technology comprise a positioning and stabilising structure to hold a seal-forming structure in a therapeutically effective position on a head of a patient. The seal-forming structure may be constructed and arranged to form a seal with a region of the patient's face surrounding an entrance to the patient's airways for sealed delivery of a flow of air at a therapeutic pressure of at least 4 cmH2O with respect to ambient air pressure throughout the patient's respiratory cycle in use. The positioning and stabilising structure may comprise at least one gas delivery tube to deliver the flow of air to the entrance of a patient's airways via the seal-forming structure. The positioning and stabilising structure may comprise an adjustment mechanism for adjustment of a length of the at least one gas delivery tube to enable the positioning and stabilising structure to fit different size heads.

Abstract: Nasal cannulas for providing respiratory therapy to patients can have a body, two prongs extending from the body, and a gases inlet on one side of the body. There can be a throttle or internal localized reduction in the cross-sectional area of a cavity defined by the internal walls of the cannula body in between the prongs. In at least some arrangements, the throttle can partially or substantially fully equalize flow between the prongs of the cannula.

Abstract: The present invention generally relates to, amongst other things, systems, devices, materials, and methods that can improve the accuracy and/or precision of nitric oxide therapy by, for example, reducing the dilution of inhaled nitric oxide (NO). As described herein, NO dilution can occur because of various factors. To reduce the dilution of an intended NO dose, various exemplary nasal cannulas, pneumatic configurations, methods of manufacturing, and methods of use, etc. are disclosed.

Abstract: A nasal patient interface arrangement is for transporting breathing gas from a pressurized gas supply to a patient. The arrangement provides a first bidirectional gas passage in contact with ambient air and receives nasally expired air. The arrangement includes an inspiratory air conduit connecting to a pneumatic unit. The arrangement also includes a nose adapter for bidirectional gas transport. The nose adapter is connected to a nose of the patient. The arrangement further includes a valve arrangement controlling the passage of gas through the first bidirectional gas passage. The arrangement provides a second bidirectional gas passage which is connected to the inspiratory air conduct, the nose adapter, and the first gas passage. The valve arrangement is substantially enclosed in the first bidirectional gas passage.

Abstract: The systems and methods of the present disclosure are for use in a medical procedure, in which a connection mechanism is provided with a first end connected to a medical system interface at a first joint and a second end connected to an anatomic orifice device at a second joint. The anatomic orifice device is fixedly coupled to a patient. A flexible portion is provided between the first and second ends, the flexible portion being able to provide flexibility in at least one degree of freedom in response to movement of the anatomic orifice device.

Abstract: Devices and methods for providing respiratory therapy are disclosed. One device includes a first lumen, a second lumen, and a bridge with at least one opening. The first lumen has a first inlet end to receive a first flow of breathing gas, a first outlet end to deliver the first flow, and a first bend between the first inlet end and the first outlet end. The second lumen has a second inlet end to receive a second flow of breathing gas, a second outlet end to deliver the second flow, and a second bend between the second inlet end and the second outlet end. The bridge separates the first lumen and the second lumen, attaches to the first lumen at the first bend and the second lumen at the second bend, and is configured to maintain the first flow of breathing gas separate from the second flow of breathing gas.

Abstract: A system having a scope with a longitudinal length extending between a proximal end and a distal end includes a plurality of markers spaced along the longitudinal length. The system also includes a disassociation and positioning device that is configured to enhance unsedated transnasal endoscopic procedures by at least partially occluding the vision of a patient while enabling body cavity access, and optionally record and sense body functions such as temperature, heart rate and oxygenation of the blood stream. The system further includes a sensor integrated into the distraction device, wherein the sensor is configured to detect the markers on the longitudinal length of the scope.

Abstract: A nebulizer device for administering aerosol cannabinoid mixtures to a user includes a mouthpiece, a first reservoir, a second reservoir, and a nebulizer device. The nebulizer module is configured to receive a first dosage of the first liquid from the first reservoir and a second dosage of a second liquid from the second reservoir. The nebulizer module is also configured to transform the first liquid into an inhalant and the second liquid into an aerosol that are provided to the user through the mouthpiece. The device further includes a dosage module configured to independently control the delivery of the first liquid and the second liquid to the nebulizer module to set a ratio between the first dosage of the first liquid and the second dosage of the second liquid. The dosage module thereby controls a composition of an aerosol cannabinoid mixture administered to the user.

Abstract: A high flow therapy system for delivering heated and humidified respiratory gas to an airway of a patient includes a respiratory gas flow pathway for delivering the respiratory gas to the airway of the patient by way of a non-sealing respiratory interface; wherein flow rate of the respiratory gas is controlled by a microprocessor, a mixing area for mixing a first gas and a second gas in the respiratory gas flow pathway, a humidification area downstream of the mixing area and configured for humidifying respiratory gas in the respiratory gas flow pathway, and a heated delivery conduit for minimizing condensation of humidified respiratory gas.

Abstract: Provided herein is a capnography fitting for use in a capnography system wherein the capnography fitting is configured to fit inhalation masks of various sizes and shapes so that viable carbon dioxide readings can be obtained from an air sample obtained from a patient's exhaled gas. The fitting includes a rigid tube having a proximal end inlet configured to receive an inhalation gas and to slidably engage a mixed gas fitting, and a distal end outlet configured to slidably engage directly to an inlet of an inhalation mask configured to cover a nose and/or mouth. The tube also includes an angled port in fluid communication with and disposed adjacent to the proximal end inlet or the distal end outlet. Methods and kits are also provided.

Abstract: A nasal cannula device includes a cannula body. The cannula body includes an accommodating chamber inside and includes two nasal joint tube extended outwardly and communicating with the accommodating chamber. A junction ring is formed between the cannula body and each nasal joint tube. At least one of the cannula body and each nasal joint tube includes a recessed annular section recessed at one side of each junction ring. The recessed annular section has a thickness smaller than a thickness of the cannula body, a thickness of each nasal joint tube, and a thickness of each junction ring. Accordingly, the nasal cannula device can deliver a therapeutic gas smoothly.

Abstract: The apparatus, method, and system disclosed relates to a headgear assembly for a respiratory system for the delivery of respiratory therapy to a patient. The headgear comprises a yoke at least partially formed from an elastomeric material. The yoke is configured to be stretched under tension to attach the yoke to the headgear assembly.

Abstract: A resuscitation bag system (1) useable for resuscitating a person in cardiac arrest, and having a gas control unit (90) with a first valve (92) fluidly connected to a first (922) and to a second conduit (923), the first (922) and second conduits (923) being arranged in parallel and further fluidly connected to the first conduit element (56), the first conduit (922) having a first flow restriction (924) configured for limiting the gas flow to a first flowrate, and the second conduit (923) comprising second flow restriction (925) configured for limiting the gas flow to a second flowrate, with the second flowrate being less than the first flowrate.

Abstract: A nasal cannula includes a distribution conduit running along a virtual distribution path. The distribution path defines a longitudinal direction and has two branch openings. A respective supply conduit branches off from each branch opening. The distribution conduit also has two coupling openings arranged spaced apart from the branch openings. The nasal cannula has a plug via which one of the two coupling openings can be sealed as a closure opening. Another of the two coupling openings is designed as a supply opening. The plug has a flow-directing configuration with an exposed flow-directing surface. In a reference state in which the plug is closing the closure opening, the flow-directing surface is arranged in the distribution conduit in the longitudinal extension region of at least one branch opening and positioned relative to the distribution path to deflect treatment gas flowing in the distribution conduit from the supply opening along the distribution path towards at least one of the branch openings.

Abstract: A portable oxygen concentrator retrofit system and method in which an existing portable oxygen concentrator may be retrofitted to output an enriched oxygen gas at a flow rate suitable for use in a patient ventilation system without the need for an external source of compressed gas.

Abstract: A headgear assembly includes a first arm member and a second arm member each having a first end and a second, opposing end. The first end of the first arm member has a structure sized and configured to engage a first rotation-resistant coupling of a frame in a manner which prohibits rotation of the first arm member with respect to the frame in a first plane in which the first arm member is located. The first end of the second arm member has a structure sized and configured to engage a second rotation-resistant coupling of the frame in a manner which prohibits rotation of the second arm member with respect to the frame in a second plane in which the second arm member is located. The assembly further includes a strap member coupled to the first and second arm members.

Abstract: A method and apparatus for providing ventilatory assistance to a spontaneously breathing patient an error signal (56) is computed that is the difference between a function of respiratory airflow (54) over a period of time and a target value (52). Using a servo loop, air is delivered to the patient at a pressure that is a function of the error signal, the phase of the current breathing cycle, and a loop gain that varies depending on the magnitude of the error signal. The loop gain increases with the magnitude of the error signal, and the gain is greater for error signals below a ventilation target than for error signals above the ventilation target value. The target value (52) is an alveolar ventilation that takes into account the patient's physiologic dead space.

Abstract: A patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways comprising: a cushion member that includes a retaining structure and a seal-forming structure permanently connected to the retaining structure; a frame member attachable to the retaining structure; and a positioning and stabilising structure attachable to the frame member.

Abstract: Embodiments of the present disclosure include a nasal pillow apparatus having a first nasal pillow, a second nasal pillow, and a connecting bar that connects the first nasal pillow to the second nasal pillow, the connecting bar being disposed below a bottom surface of the first nasal pillow and a bottom surface of the second nasal pillow. Each of the first nasal pillow and the second nasal pillow includes an inner wall having a first end and a second end opposite the first end; and an outer wall connected to the second end of the inner wall. When inserted into a nostril of a patient, the outer wall is configured to conform to the nostril by compressing in a first direction and expanding in a second direction.

Abstract: A gas delivery conduit adapted for fluidly connecting to a respiratory gases delivery system in a high flow therapy system. In one embodiment, a nasal cannula includes a base portion defining a first therapeutic gas passageway, a nozzle disposed adjacent the base portion and defining a second therapeutic gas passageway, the first passageway being in gaseous communication with the second passageway and a conduit configured to facilitate sensing that has an inlet side that is independent of and axially spaced apart from an outlet side of the nozzle. The conduit inlet side can extend beyond the nozzle outlet side of the nasal cannula. Additionally, the nasal cannula has a feature adapted to prevent one of the conduit and the nozzle from creating a seal with a user's rare and a feature adapted to prevent one of the conduit and the nozzle from creating a seal with a user's nare.

Abstract: An endotracheal tube includes a main tubular portion including a distal end and a proximal end opposite the distal end, the main tubular portion including a central lumen at least in part defined by a wall of the main tubular portion; a wire lumen disposed within the wall of the main tubular portion, the wire lumen defined at least in part by a sidewall portion of the wire lumen and extending from about the proximal end of the main tubular portion to about the distal end of the main tubular portion; a wire disposed in the wire lumen; and one or more cutouts extending along a portion of the wall of the main tubular portion, the cutouts comprising openings in the sidewall portion of the wire lumen, wherein the cutouts are not in fluid communication with the central lumen.

Abstract: A patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways comprising: a cushion member that includes a retaining structure and a seal-forming structure permanently connected to the retaining structure; a frame member attachable to the retaining structure; and a positioning and stabilising structure attachable to the frame member.

Abstract: A mask assembly for use as part of an apparatus for supplying a flow of respiratory gases to a user is disclosed. The mask assembly includes a mask body having an inlet through which said flow of respiratory gases are provided to the interior of said mask body. A mask seal assembly comprising a seal of flexible material and a clip of rigid material is attached to the body. The seal has a first side and a second side. The first side of the seal is shaped to approximately match the contours of a user's face and in use substantially seal against a user's face. The second side is attached to the clip. The clip provides an interface extending substantially the full perimeter or periphery of the mask seal assembly for releasably attaching the mask seal assembly to the mask body. The clip comprises a bridging portion spanning outwards from the perimeter or periphery of the mask body to space at least a portion of the second side of the seal outwards from the perimeter or periphery of the mask body.

Abstract: Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.

Abstract: A head-mountable flow generator is configured to deliver a flow of breathable gas at a continuously positive pressure with respect to ambient air pressure to a patient interface in communication with an entrance to a patient's airways including at least an entrance of the patient's nares, while the patient is sleeping, to ameliorate sleep disordered breathing. The flow generator includes a motor, an impeller assembly and housing that encases the motor and the impeller assembly. The housing is configured to be mounted on the patient's head and comprises an inlet to receive the flow of breathable gas and a pair of opposing outlets to deliver the flow of breathable gas. In addition, the impeller assembly is configured to pressurize the flow of breathable gas received from the inlet, and the housing is configured to convey the pressurized flow of breathable gas through both outlets.