Abstract: The disclosed apparatus, systems and methods relate to the delivery of personalized nutraceutical products to a subject, comprising a library of actives; a software module; and a dispensing unit. In certain aspects, the system further comprises a packaging unit and a delivery unit. According to certain aspects, the library of actives comprises a plurality of active nutraceutical ingredients formulated for precise dispensing. In further aspects, the software module is constructed and arranged to receive prescription information for the subject and to output dispensing instructions to the dispensing unit. In still further aspects, the dispensing unit is constructed and arranged to receive dispensing instructions from the software module and to dispense one or more actives from the library of actives to form a nutraceutical product, and wherein the dispensing instructions are derived from the prescription information and customized to the nutritional needs of the subject.

Abstract: A fluid transfer device (10) includes a vial holder (23) configured to hold a vial (22). An actuator (40) is coupled to the vial holder (23) and can rotate the vial (22) between upright and inverted positions. A pump (positive or negative pressure) can pump contents out of the vial (22). Before pumping of the contents the actuator (40) rotates the vial (22) to the inverted position and after pumping of the contents the actuator (40) rotates the vial (22) to the upright position.

Abstract: A testing assembly for a drug delivery device is disclosed. The testing assembly can include a pressure vessel having a sealed pressure chamber that is configured to be pressurized to a predetermined pressure. The pressure vessel further defines an injection opening extending from an exterior thereof to the pressure chamber. A pierceable barrier extends over and seals the injection opening. The testing assembly further includes a measurement device disposed within the pressure chamber and a container aligned with the injection opening, such that the container is configured to collect a dose of a drug delivered via a drug delivery device through the pierceable barrier and the measurement device is configured to measure the dose of the drug.

Abstract: The invention relates in particular to a device (100) for collecting a sample of a liquid in a container, characterized in that it has: a housing (10) with a longitudinal axis (AL); a component (20, 20?, 20?) comprising: a body (26) provided with at least one channel (21) having a proximal end (21p) and a distal end (21d); a receptacle (24) fixed with respect to the body (26) and situated in the continuation of the proximal end (21p) of said at least one channel (21), said component (20) being mounted rotatably with respect to the housing (10) about the longitudinal axis of this housing (10) between a closure position, in which the distal end (21d) of said at least one channel (21) is closed by the housing (10), and an open position, in which the distal end (21d) of said at least one channel (21) is able to establish a fluidic communication with the container; and an elastic valve (30) housed in the receptacle (24).

Abstract: A detecting machine for detecting a metal foreign object in a to-be-detected object that includes a tag is provided. The detecting machine includes: abase unit that includes an overhead arch; a detecting unit that generates a magnetic signal in response to the to-be-detected object moving past the overhead arch; a tag reader that detects the tag on the to-be-detected object and that generates a tag signal; a display unit that includes a first display and a second display; and a processor that is configured to control the display unit to display information regarding the magnetic signal and the tag signal on the first and second displays.

Abstract: A microfluidic check valve includes an inlet bore, an internal chamber, an outlet bore, and a disk freely movable in the chamber between an open position and a closed position. At the open position, the disk permits fluid to flow from the inlet bore, through the chamber, and to the outlet bore. At the closed position, the disk prevents fluid from flowing in the reverse direction from the chamber into the inlet bore. The check valve may be positioned in-line with a fluid conduit, and/or incorporated with various fluidic devices such as, for example, capillary tubes, fittings, and chromatography columns. The check valve is capable of withstanding high fluid pressures, while featuring a small swept volume, such as a nano-scale volume. The check valve may be utilized, for example, to prevent fluid back flow and isolate pressure pulses in fluid flow systems.

Abstract: An object of the present invention is to provide a dispensing device that can inhibit a dead volume from occurring and can dispense a liquid of a small quantity with a high degree of accuracy while reducing the variation of dispensing quantities. A dispensing device according to the present invention has a detachable dispensing tip and the dispensing tip has a configuration of arranging a plunger in a hollow part of a metal pipe (refer to FIG. 2).

Abstract: An ear endoscope device for use in a surgical procedure in an ear includes a handle, a visualization shaft extending from the handle, a tool guide extending from the handle parallel to the visualization shaft and configured to guide a tool into the ear with the visualization shaft, an imaging sensor at a distal end of the visualization shaft, and a light source. In some embodiments, the ear endoscope is combined with a suction device. In other embodiments, it may be combined with another tool.

Abstract: A filling machine includes a main body, a feeding unit, a movement unit, a power unit, a pipe unit, and two control units. The main body is provided with a first seat and a first mounting portion. The feeding unit is mounted on the main body and includes a second seat, a filling cylinder, a first plate, and a connecting member. The movement unit is movable relative to the feeding unit and includes a third seat, a first moving member, and a second plate. The power unit is arranged on the movement unit and includes a driving mechanism, and a second moving member. The pipe unit is assembled with the feeding unit, and includes a first line and a second line. The two control units are mounted on the main body to open or close the first line and the second line.

Abstract: A storage unit for storing a fluid, the storage unit comprising at least one wall defining a chamber and an opening. The storage unit comprises a storage unit valve arranged at the opening to selectively seal the chamber. The storage unit valve is able to be selectively opened and closed to allow fluid to flow through the storage unit valve. The storage unit comprises a storage unit keying mechanism configured to allow the storage unit to only connect to a complementary docking station keying mechanism disposed on a docking station for receiving the storage unit. The storage unit valve is configured to only be able to be selectively opened and closed when the storage unit keying mechanism is engaged with said complementary docking station keying mechanism.

Abstract: A method is disclosed for clearing effusion from an ear. The method may include applying liquid to an ear canal, which is proximal to a perforated tympanic membrane, which is proximal to a middle ear containing effusion, applying an ear device to seal and pressurize the liquid inside the ear canal, the ear device regulating the amount of pressure inside the ear canal, and inducing a Eustachian tube, which is distal to the middle ear, to open, which causes the fluid to displace the effusion into the Eustachian tube.

Abstract: The invention relates to a pipetting device, more particularly a pipette or repeater pipette, for pipetting fluid laboratory samples, comprising: an electric control apparatus, by means of which a pipetting process is electrically controllable, a movable part, by means of the movement of which the fluid sample is pipettable, an electrically actuatable motor apparatus, by means of which the movement of the movable part is driveable depending on at least one first speed value defining the speed of the movable part, a measuring apparatus, by means of which at least one measured value which is influenced by the drag caused when pipetting the fluid sample is measurable, wherein the electric control apparatus is configured for the purposes of the at least one first speed value being fixable by the electric control apparatus, depending on at least one measured value. The invention furthermore relates to a method for operating the pipetting device.

Abstract: A semi-automated system (100) suitable for use in a hospital setting for filling patient-specific liquid medication prescriptions from bulk medicine containers (104) into oral/enteral syringes (S) for administration on a just-in-time basis. The system enables hospital pharmacists to simplify and streamline their task, increasing the number of prescriptions that can be filled in a day, improving patient safety and care by minimizing medication errors and the consequences that ensue.

Abstract: A septum is penetrable by a needle for decontamination by physical interaction. The septum can include a peripheral portion, an exterior surface, and an interior surface. A penetration portion extends between the exterior and interior surfaces, is spaced inwardly of the peripheral portion, and is penetrable by the needle or other penetrating element. A flex portion is located between the penetration portion and the peripheral portion. A thicker portion extends between the flex portion and the penetration portion, and defines an increased thickness between the exterior and interior surfaces relative to the flex portion. The flex portion is flexible inwardly relative to the peripheral portion during penetration of the penetration portion by a needle or other penetrating element. The penetration portion physically interacts with and decontaminates the needle when it penetrates the septum. The septum may also reduce or prevent retrograde contamination when the needle is withdrawn.

Abstract: Fluid containment pressure vessel that eliminates the outer support housing present in certain conventional vessels, and provides an improved cap-to-body interface. In certain embodiments, the cap is threaded and configured to threadingly engage with the body of the pressure vessel, and has sufficient structural integrity to withstand the pressures in the device without the need for a support housing. In certain embodiments, an interlock mechanism is provided that prevents the cap from being opened (e.g., removed from the body) while the device is under pressure. In certain embodiments, a pressure relief valve is provided with a pre-loaded biasing mechanism to achieve the required pressure release rate. The vessel can be used for sample preparation, including purification or concentration of samples, particularly protein samples.

Abstract: An apparatus for filling a product into a container is provided. The apparatus can include a filling unit that can deliver the product into the container, the filling unit can include a pump and a filling nozzle at its one end. The apparatus can also include a drive unit for moving the container in relation to the filling unit between a first position, in which a bottom end of the container is arranged at a maximum distance from the filling nozzle, and a second position, in which the bottom end of the container is arranged at a minimum distance from the filling nozzle. A controller can control delivery of the product through the filling nozzle and the drive unit.

Abstract: The present disclosure relates to a drive mechanism for a medicament delivery device according to the disclosure comprises a compression member comprising a first cavity containing a first volume of fluid, said compression member also comprising a second cavity containing a second volume of fluid; a passage for fluid communication between the first cavity and the second cavity; a first movable piston arranged to seal the first cavity; a second movable piston arranged to seal the second cavity; wherein movement of the first movable piston or of the second movable piston, by an applied force, causes a relative change of volume between the first volume of fluid and the second volume of fluid, via a fluid flow through said passage, such that the respective second movable piston or the first movable piston is also moved.

Abstract: Disclosed is a septum holder that comprises a body having an upper body part and a lower body part that has a bored out interior. An insert comprising at least one bore that forms the seat of a needle valve fits loosely into the bored out interior of the lower body part. A septum comprising an upper part is attached to an exterior surface of the lower body part of the septum holder. A lower part of the septum extends downward beyond the lower edge of the lower body part of the septum holder. The septum holder is characterized in that the insert can freely move up and down in the interior of the lower body part and the septum can freely move up and down on the exterior surface of the lower body part. Also disclosed is a connector section for a liquid transfer apparatus that comprises the septum holder.

Abstract: A high pressure delivery device for delivering a medicament includes a first chamber for storing a supply of the medicament and a second chamber in fluid communication with the first chamber. A fluid connection path is in fluid communication with the second chamber for administering the medicament. A valving system is in fluid communication with the first chamber, the second chamber and the fluid connection path. The valving system allows a dose of the medicament to be injected from the first chamber into the second chamber while substantially preventing backflow of the dose into the first chamber and substantially preventing leakage through the fluid connection path. The valving system also allows the dose in the second chamber to be administered through the fluid connection path while substantially preventing the dose from flowing back into the first chamber.

Abstract: A pneumatic needle-free injection device restores pressured air in a pressure room to deliver high pressure air instantaneously, so as to inject a dose subcutaneously, intradermally, and intramuscularly, accelerating an absorption process of skins. The device can be further linked to a high-pressured air container for portable usage.

Abstract: A device for reconstituting a pharmaceutical composition from at least a first component in a first container and a second component in a second container. The device includes a fluidic unit having a first connector coupled to the first container, a second connector coupled to the second container, a pump, and a fluidic circuit connecting the first connector, the second connector and the pump. The first connector includes a crankpin in rotating engagement within a body and including an axial port fluidically couplable to the first container, a radial port fluidically connected to the axial port of the first connector, and at least one channel arranged therein so as to cooperate with the radial ports of the body of the first connector to selectively connect the axial port of the first connector with at least one channel portion of the fluidic circuit depending on the angular position of the crankpin.

Abstract: A closed fluid transfer system for fluidly interconnecting a syringe to any one of a patient I.V. set, a vial and an I.V. bag, is provided and includes a first adapter defining a lumen and supporting a seal across a first end of its lumen, the first adapter supporting a rear end of a needle within the lumen, wherein the seal is movable relative to the needle such that a tip of the needle penetrates through the seal; and a second adapter defining a lumen and supporting a seal across a first end of its lumen; wherein when the second adapter is coupled to the first adapter, the second adapter seal abuts the first adapter seal and moves the first adapter seal relative to the tip of the needle such that the tip of the needle penetrates through the abutting first adapter seal and second adapter seal.

Abstract: A device comprises a syringe comprising a syringe body portion and a plunger portion configured to engage with and slide axially within the body portion; a tube set fitted to the syringe. The tube set may comprise a proximal tube attached to the plunger portion at a proximal end thereof and terminated, at a distal end thereof, by a beak assembly configured to assume a first configuration suitable for coring through tissue and a second configuration suitable for tissue penetration and parting off tissue; and a distal tube disposed over and coupled to the proximal tube to enable travel-limited axial displacement relative to the proximal tube. Axially moving the plunger portion of the plunger portion within the body portion of the syringe causes differential movement of the proximal tube relative to the distal tube to selectively cause the beak assembly to assume the first or the second configuration.

Abstract: A vial access device includes an outer housing defining an annular space and an inner space, an inner housing, and a connector configured to engage a mating connector with the connector having a body defining a central passageway and a flange that extends radially outward from the body. The flange and the housing defining a filter space that is in fluid communication with the annular space. A pressure equalization system is positioned within the annular space of the outer housing. The device also includes a vial connection element configured to be secured to a vial and having a body and a spike member extending from the body. The spike member defining a fluid passageway and a vent passageway with the fluid passageway in fluid communication with the central passageway of the connector and the vent passageway in fluid communication with the filter space and the annular space.

Abstract: Various embodiments of the present invention are directed to transferring fluidic media from a vial to a reservoir. In various embodiments, fluidic media may be transferred from the vial to the reservoir by moving a housing portion to move a plunger head located in the reservoir to draw fluidic media from the vial to the reservoir. In other embodiments, fluidic media may be transferred from the vial to the reservoir while the reservoir is held by a holding unit and vibrated by a vibrator to remove air from the fluidic media. In some embodiments, fluidic media may be transferred from the vial to the reservoir by moving a handle operatively connected to a bias member for assisting with the transfer of fluidic media. In other embodiments, the transfer of fluidic media may be assisted by a bias member and a needle connecting atmosphere and the vial.

Abstract: A fuel changing device which is for connection with a fuel pipe or a fuel can is provided, including: a barrel, connected with a conduit portion communicating with an interior of the barrel; a plunger, including a piston movably received in the barrel and an operation rod connected with the piston and extending out of the barrel; an adapting mechanism, including an adapter connected to the conduit portion and at least one adapting tube, the adapter selectively detachably connected with one end of the adapting tube or for selectively detachably connected with a fuel connector of the fuel can, another end of the adapting tube being for detachably connected with the fuel pipe.

Abstract: Paste food dispensation devices and tillable, sealable sachets or pouches for food use are known in the art. The present invention provides a food dispensing system that enables food to be mashed within a hopper, and then to be dispensed into a pouch by way of a plunger formed from a masher with a cover on the head of the masher.

Abstract: A fluid transfer system (100) includes a transfer device (104) and an interface device (102). The transfer device (104) includes a fluid transfer member (164) and a transfer coupling member (125) to align the fluid transfer member (164) with the interface device (102). The interface device (102) includes a reservoir port (108), a fluid transfer member receptacle (144), an interface coupling member (124), and a reservoir valve (110). The interface coupling member (124) is configured to close the fluid transfer member receptacle (144) and to couple to the transfer coupling member (125) and open the fluid transfer member receptacle (144) to receive the fluid transfer member (164). The reservoir valve (110), e.g., a sliding seal, is configured to close the reservoir port (108) from the fluid transfer member receptacle (144) and to open the reservoir port (108) to the fluid transfer member (164) when the fluid transfer member (164) is positioned in the fluid transfer member receptacle (144).

Abstract: Various embodiments of the present invention are directed to transferring fluidic media from a vial to a reservoir. In various embodiments, fluidic media may be transferred from the vial to the reservoir by moving a housing portion to move a plunger head located in the reservoir to draw fluidic media from the vial to the reservoir. In other embodiments, fluidic media may be transferred from the vial to the reservoir while the reservoir is held by a holding unit and vibrated by a vibrator to remove air from the fluidic media. In some embodiments, fluidic media may be transferred from the vial to the reservoir by moving a handle operatively connected to a bias member for assisting with the transfer of fluidic media. In other embodiments, the transfer of fluidic media may be assisted by a bias member and a needle connecting atmosphere and the vial.

Abstract: A vehicle includes a brake system. The brake system includes a hydraulic brake line having a line pressure. The vehicle additionally includes a vacuum reservoir. The vacuum reservoir is selectively fluidly coupled to the hydraulic brake line. The vacuum reservoir is configured to, when fluidly coupled to the hydraulic brake line, reduce the line pressure during a drive cycle.

Abstract: A blinding device for administering a substance to a patient in a clinical trial is presented where the blinding device has an opaque housing to receive at least two delivery devices adapted to dispense a substance provided therein, an outlet being in fluid communication with at least one delivery device for administering the substance to a patient, and at least one actuating member mechanically engageable with at least one delivery device and being actuatable from outside the housing.

Abstract: A system for titrating liquids, with a syringe or tip, comprising a holding device and at least one tag and a metering equipment, comprising an additional holding device for holding the syringe or tip on the holding device, a reading device for reading the tag of the syringe or tip held by the additional holding device, a driving device having a motor, which is detachably coupled with a plunger of the syringe when the same is held by the additional holding device, or which is coupled with a plunger which is arranged in a cylinder which is coupled with the tip via a fluid conduit, when the same is held by the additional holding device, an operating device for operating the metering equipment and a control device, connected with the operating device, the reading device and the driving device, which controls the movement of the plunger depending of the tag of the inserted syringe or tip.

Abstract: Syringes for providing fluid communications are provided. The syringes include a connector body section having a tip portion and a gravity-assisted valve, and a barrel section. One or more syringes include a configuration of the gravity-assisted valve to allow bidirectional fluid communications between the tip portion and a fluid reservoir when the syringe is pointed downward. One or more syringes include a configuration of the gravity-assisted valve to prohibit fluid communication from the fluid reservoir to the tip portion when the syringe is pointed upward. One or more syringes include a gas pathway extending from an interstitial space of the connector body section to an interior volume of the plunger defining a gas reservoir.

Abstract: A method for transferring a viscous material into a syringe that has a plug dividing a syringe interior into a first sub-chamber and a second sub-chamber, where a radial clearance exists between the plug and the syringe, includes transferring the viscous material from a container into the first sub-chamber to fill the first sub-chamber while allowing air initially present within the first sub-chamber to flow into the second sub-chamber via the radial clearance, and flowing a first volume of the viscous material into but not through the radial clearance such that the viscosity of the first volume of the viscous material and the radial clearance cooperate to block a flow of a second volume of the viscous material into the radial clearance and prevent the second volume of the viscous material from leaking from the first sub-chamber into the second sub-chamber.

Abstract: A liquid collection device is configured to determine a difference between a liquid level after suction operation determined by calculation based on the liquid level detected at the time of previous probe lowering operation and a liquid level that is actually detected at the time of current probe lowering operation, to detect presence of foam if the difference is greater than a first threshold set as a maximum value of an allowable error set in advance in the device and is equal to or smaller than a second threshold that is set greater than the first threshold, and moreover, to display a warning to an operator when presence of foam is detected.

Abstract: An apparatus for filling drug containers such as syringes, and related filling methods, are disclosed. The apparatus uses a removable pumping syringe mounted to the apparatus and located intermediate between the bulk source of drug and the container (e.g. syringe) to be filled such that the drug is first pumped into the pumping syringe and then pumped into the container (e.g. syringe). Actuation of the intermediate pumping syringe is effected with a linear actuator such as a step motor which is engaged to the plunger of the pumping syringe. The linear actuator is controlled by a controller which typically allows different filling and calibrating procedures.

Abstract: An adaptor for coupling with a medical container, including: a tubular body receiving a pierceable elastomeric piece, defining an inner cavity of the adaptor, the pierceable elastomeric piece being movable within the tubular body between a first position, in which a distal part of the pierceable elastomeric piece forms a seal of the cavity, and a second position, proximally spaced from the first position, in which the distal part opens the seal of the cavity, an air inlet, a filtering system for filling the inner cavity with decontaminated air, and a gripping member for securing the adaptor to the medical container. Also, an assembly comprising such an adaptor and a medical container.

Abstract: Provided herein is a pipette tip (600) for electroporation including an outer surface, a void (611) located within the outer surface, and a conductor (622) located at least partially on or within the outer surface, in electrical communication with at least a portion of the outer surface and the void. Further provided herein is a pipette tip for electroporation including a body, a connector (620), and an elongated part (630). The connector is located at the distal end of the body and further includes at least one connecting post, a connecting part in mechanical communication with the connector, and a conductor located at least partially on or within the connector, wherein the conductor surrounds at least a portion of the connecting post. The elongated part also has a void and is located at the distal end of the connector. The void of the body, connector, and elongated part are in fluid communication.

Abstract: The application describes innovative designs for components of a drug transfer apparatus that overcome problems encountered in daily use of prior art apparatuses. Specifically described are components configured to prevent liquid from entering the air chamber of syringes coupled to the apparatus and to prevent tearing of the rubber stopper of drug vials when they are attached to the apparatus.

Abstract: A multi-vial dispensing cassette provides serial dispensement of radiopharmaceutical fluid into a plurality of dispense vials connected in series. Needle holders may be provided for one or more vials in the cassette and at clip may be incorporated into the needle holder. Each dispense vial has a body and a cap with a fill needle and a withdrawal needle. The withdrawal needle of one vial is connected to the fill needle of an adjacent vial.

Abstract: A fluid transfer device for transferring fluid between a supply reservoir and a fill reservoir includes a metering reservoir and a manifold that forms at least part of a first channel that is fluidly connected with the metering reservoir. The first channel comprises a first cannula extending from the manifold. The manifold forms at least part of a second channel fluidly connected with the metering reservoir. The second channel comprises a second cannula extending from the manifold. A third channel extends through the manifold and comprises a third cannula having a first end proximate a distal end of the first cannula and a second end proximate a distal end of the second cannula. A first check valve is disposed within the first channel and a second check valve is disposed within the second channel.

Abstract: Provided is a liquid container having a vacuum pumping device, which includes: a housing having a lower portion which is opened by means of an opening or closing control to be exposed to the atmosphere and an upper portion having a mounting hole so that a space is formed therein; an inner container having a cylinder chamber provided at an upper portion thereof to allow a liquid to flow in or out and a liquid store area connected to a lower portion of the cylinder chamber to change a volume according to an amount of liquid therein, the cylinder chamber being coupled to the mounting hole of the housing so that the inner housing is detachably mounted in the housing for refilling; a syringe unit coupled to or separated from the cylinder chamber to suck the liquid from the inner container and discharge the sucked liquid outwards; and an elastic cap mounted to the cylinder chamber, the elastic cap being closed in advance when the syringe unit is inserted into the cylinder chamber and opened later when the syringe u

Abstract: A cartridge syringe has a housing with an opening for inserting the cartridge having a cylinder filled with a medication and closed at its ends by a piercing membrane and a stopper having a blind hole. A ram is provided for pressing the stopper for injecting the medication in the cylinder after piercing the membrane. The ram has an actuating element and can be attached in the blind hole of the stopper for aspiration. The ram has an outer sleeve with a core. The outer sleeve is displaceably guided in a rotatable manner and the core in a rotationally fixed manner. A front end of the outer sleeve is provided with at least one fixing hook which is spring-loaded inwardly A cam is engageable with the fixing hook such that, upon rotation of the outer sleeve, the fixing hook is movable either to the fixing position or to the unlocked position.

Abstract: A system and method for improving operation of a needle trap by changing a flow path through a needle trap to enable a needle to draw a fluid sample into a working end of the needle and out through the side hole, wherein drawing the sample through the side hole eliminates the possibility of a leak through the side hole while drawing a fluid sample into the working end.

Abstract: An apparatus and method for preparing a pharmaceutical for transient application includes a tray having a sealed compartment, a vial of an ophthalmic formulation of mitomycin-C, a diluent carrier containing sterilized water, and a syringe that are all contained together in a single package. The component parts of the apparatus are used together to reconstitute the contents of the vial with the water in the diluent carrier, and then draw the reconstituted drug into the sealed compartment of the tray by a suction force produced by the syringe. In the tray compartment, the reconstituted drug is absorbed in at least one absorbent pad. The absorbent pads may come in multiple shapes and or/sizes. The tray is opened to remove the pad and the absorbed drug from the tray compartment for use of the pad in transient application of the drug.

Abstract: A drug eluting catheter includes an active agent, such as a drug or chemical substance, which is integrated with the catheter and allows variable dosing of the agent for elution to the patient's body. The catheter includes a dosing region and graduated markings or is associated with a measurement device that includes graduated markings that correspond to a range of dose of the active agent associated with the catheter. By removing or masking an undesired dosing region prior to administration, a user may vary the dosage to suit a patient's needs.

Abstract: A robotic intravenous automation system, including a robotically controlled holder configured to manipulate an intravenous (IV) bag and a closed system transfer device (CSTD). The controller includes a processor configured to control the holder. The IV bag includes a first fluid port and a second fluid port, and the CSTD includes a CSTD port, a spike adapter that is fluidically separated from the CSTD port, and a flexible member connecting the CSTD port to the spike adapter.

Abstract: A refillable dispenser for viscous compositions comprises a bottle having walls defining an upper cavity and a lower cavity, a viscous composition refill mechanism configured to allow viscous composition to enter the upper cavity when the refill mechanism is fluidly coupled to a viscous composition source and a viscous composition dispensing mechanism configured to allow viscous composition to be dispensed from the upper cavity to outside the bottle when the dispensing mechanism is actuated. A gasket configured to substantially seal the upper cavity from the lower cavity is provided wherein the gasket is capable of moving towards the upper cavity upon actuation of the dispensing mechanism and moving towards the lower cavity upon entrance of the viscous composition into the upper cavity.

Abstract: A pressure-stable cylinder/piston unit which blocks water vapor and oxygen and is designed for a needle-free injector, with a chamber arranged in a cylinder, which blocks water vapor and oxygen, and designed for long-term and sterile storage of an injection solution, an end wall with at least one nozzle bore or one outlet element, a pressure-stable outer cylinder, and a pressure-stable piston arranged movably in the chamber and blocking water vapor and oxygen. Methods for bubble-free, automatic or manual filling of the cylinder/piston unit, also at atmospheric pressure are also disclosed.

Abstract: The drug delivery device (1) connects an syringe barrel (6) and a drug container (2) by means of a closed system, and delivers a drug between the syringe barrel and drug container through said closed system. This drug delivery device includes a first member (8) connected to the drug container (2) on the side of a stopper (4), and a second member (30) connected at one end to the first member and connected at the other end to the syringe barrel (6). The first member and the second member are connected by a fitting mechanism. A second hollow needle member (34) provided on the second member faces towards the first member, and the tip portion (36) and the base portion (38) are fixed. The first member has a first hollow needle member (12). The first member and the second member each have an elastic member (18 and 40).