Abstract: Light-protective container assembly for a light-sensitive fluid includes a translucent container defining an inner reservoir to contain the fluid, and a flexible sleeve connected to the container. The sleeve has a tubular configuration sized to substantially cover at least the reservoir of the container, and is made of a material capable of substantially preventing the transmission therethrough of an identified range of wavelengths from the electromagnetic spectrum. Preferably, the sleeve is made of a mixture of a base material and a colorant capable of substantially preventing the transmission of undesired energy through a predetermined thickness of the base. material. The sleeve is connected indirectly to the container by providing the container with at least one passageway therethrough, and by positioning the sleeve such that a first portion of the sleeve is on one side of the container, and a second portion is on an opposite side of the container.

Abstract: An easily-handleable inclusion packaged product having thin-leaf inclusion articles which are prevented from contacting with external atmosphere to give a satisfactorily sanitation. The product can be produced by the steps of (1) coating a solution of an inclusion article on a base sheet, (2) drying the coated solution, and (3) sealing prescribed sections of the base sheet and an overlapping sheet by laminating the overlapping sheet on the base sheet to surround the area coated with the solution.

Abstract: A dual-filled twin bag, a packaging including the twin bag, and a method for forming the packaged twin bags are provided. Each of two bags, a solution bag (10)and a drain bag (12) for a system used for a peritoneal dialysis procedure, are filled, at least partially, with a solution (14). A tubing set (16) connects the two filled bags (10,12) and may also be filled with solution (14) which is added to the bags (10,12) and the tubing set (16) during the manufacturing process. Alternatively, the tubing set (16) may be filled with air. The tubing set (16) is sandwiched between the solution bag (10) and the drain bag (12) and subsequently packaged in an overpouch (24). The method for forming the package including the bags filled with solution is simplified and the overall package size is reduced due to the sandwiched tubing set (16) between the solution bags (10,12) and the provision of solution in both bags (10,12).

Abstract: A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagulation of the blood, separating the blood into two components, one of which is extremely rich in white blood cells through the use of a reagent and centrifugation, sequestering the white cell concentration, and freezing the white cells.

Abstract: The present invention relates to an impermeable flexible multicompartment bag for medical use for sterile solutions, and to a method for the preparation of such bags. Impermeable flexible multicompartment bags for medical use for sterile solutions for perfusions, consisting of two welded sheets of a composite material wherein the sheets forming the inner wall of the bag consist of a polypropylene and are bonded to an outer layer of a thermoplastic polymer by means of a polyolefin layer, characterized in that the sheets facing the contents of the bags which are made of a homophase copolymer of propylene are immediately welded in the intercompartment region and in the peripheral region such that the weld forming the intercompartment region can be ruptured with a force in the range of from 10 to 30 N while the weld in the peripheral region cannot be ruptured.

Abstract: A method of rendering antiseptic a packaged solid admixed emulsion for treating bleeding cuts and the like containing, dispersed therein, a bactericidal component that is solid at room temperature, such as cinnamic alcohol, but melts or liquefies at blood temperature upon contacting the blood, comprising elevating the temperature of the packaged emulsion and/or contacting with moisture briefly to commence such liquefying to wet the exterior surface of the solid emulsion, and with concurrent release of bactericidal vapor within the package, and the resulting antiseptic solid emulsion products produced thereby.

Abstract: A method and apparatus for maximizing fluid retrieval from a fluid container when using a fluid retrieval device. A medical container is provided which includes a container body to hold a volume of medicinal fluid, and a container nozzle coupled to the container body. The nozzle has an opening to permit passage of a fluid retrieval device into the container body. The container includes a fluid pooling structure that guides the volume of medicinal fluid towards a target pooling region in response to a gravitational force, thereby optimizing the fluid retrieval therefrom.

Abstract: In a salt concentrate container system for a dialysis apparatus comprising a salt container consisting of a flexible bag provided at its opposite ends with connecting elements for connection with counter elements of a dialysis apparatus, a rigid bracket extends around the flexible bag and is coupled to the connecting elements at the opposite ends of the bag for firmly holding the connecting elements at a predetermined distance from each other.

Abstract: A package for tablet products that includes a container having an interior volume for holding the tablet products and a closure secured to a cylindrical finish of the container. A product hold-down device has an axially resilient central portion, a lower portion for engaging the upper surface of the product within the container, and an upper portion for securement within the container finish to hold the device in place within the finish, with the closure removed from the finish, against the axially resilient forces applied to the device by engagement of the lower portion with product in the container and resilient compression of the central portion of the device. Thus, the hold-down device can be inserted into the container and secured to the container using automatic packaging equipment, and the container closure then applied to the container. In use, the closure is removed from the container, and the device is removed and discarded by the user.

Abstract: A method and device for organizing, storing, instructing, and coordinating the combined use of topical therapeutic agents, including moisturizing agents, for the treatment of respiratory tract disorders.

Abstract: A sampler pouch having a lower barrier layer; an upper barrier layer peelably sealed to the lower barrier layer to form a cavity; and a fluidic sample material absorbed within an internal supportive structure within the cavity. The internal supportive structure is inert and substantially retains the sample material when subjected to compressive forces, thereby reducing internal pressure against the peel seal and allowing for the use of low strength peel seals.

Abstract: Multiple use universal connector designed for use in various containers having a fluid port for accessing to the content of the container or for transferring fluid into the container. The multiple use universal connector incorporates a diaphragm capable of being penetrated repeatedly by an access means such as a luer connector or a syringe having a sharp or blunt cannula for fluid communication between the content of the container and the access means. The multiple use universal connector re-seals itself after being penetrated and the access means removed therefrom.

Abstract: Methods, compositions, and compounds for modulating the activity of an endothelin peptide are provided. The methods use compositions that contain compounds of formula (1): where X and Y are selected from groups that include O, S, and NH; and Ar1, Ar2 and Ar3 are independently selected from substituted or unsubstituted groups that include 5 to 6 membered aryl groups and heteroaryl groups that contain one or two heteroatom(s). The methods are effected by contacting endothelin receptors with one or more of the compounds or with compositions containing one or more of the compounds prior to, simultaneously with, or subsequent to contacting the receptors with an endothelin peptide.

Abstract: Universal connector designed for use in various containers having a fluid port for access to the content of the container or for transferring fluid into the container. The universal connector incorporates an elastomeric membrane capable of being ruptured by an access means such as a luer connector or a syringe having a sharp or blunt cannula for fluid communication between the content of the container and the access means.

Abstract: Multiple use universal connector designed for use in various containers having a fluid port for accessing to the content of the container or for transferring fluid into the container. The multiple use universal connector incorporates a diaphragm capable of being penetrated repeatedly by an access means such as a luer connector or a syringe having a sharp or blunt cannula for fluid communication between the content of the container and the access means. The multiple use universal connector re-seals itself after being penetrated and the access means removed therefrom.

Abstract: Single use universal connector, flexible medical container assembly for the containment and delivery of medical fluid having three access means: a single use universal connector access means for luer connection, needle or spike piercing; a needle access means and a spike access means.

Abstract: Multiple use universal connector designed for use in various containers having a fluid port for accessing to the content of the container or for transferring fluid into the container. The multiple use universal connector incorporates a diaphragm capable of being penetrated repeatedly by an access means such as a luer connector or a syringe having a sharp or blunt cannula for fluid communication between the content of the container and the access means. The multiple use universal connector re-seals itself after being penetrated and the access means removed therefrom.

Abstract: A packaged skin product is provided which includes at least one regular or irregular polygonal shaped patch for adhesive application to the skin. An outer carton formed of a series of walls functions as a receptacle for storing the patches. A front wall of the outer carton includes a window of a size and shape identical to one of the patches. A plurality of these patches adhere to a single backing sheet which is enclosed within a sealed laminated pouch. The window serves to inform a potential customer as to the size and visual nature of the enclosed patches.

Abstract: A drug or other medication is incorporated into a candy and is molded onto a lollipop stick. A medicated lollipop is safely and conveniently stored by mounting the end of the lollipop stick remote from the medicated candy to the inner surface of a childproof cap. The lollipop then is inserted into a container, and the childproof cap is releasably locked with the open top of the container. The medicated lollipop can be accessed as needed merely by opening the container. Additionally, the medicated lollipop can be temporarily stored away from the container merely by converting the cap, and supporting the medicated lollipop by the cap.

Abstract: The invention features an empty device for receiving a bioactive agent. The device includes a biocompatible and semi-permeable membrane that defines an enclosed space; the membrane also has at least one end that defines an opening for introducing the bioactive agent into the enclosed space. The device is configured to be placed in an animal.In one embodiment of the invention, the membrane has an inner surface and an outer surface, where the inner surface defines the inner surface, and includes a biocompatible adhesive in the general region of the opening to allow sealing of the opening after the introduction of the bioactive agent into the enclosed space.Another embodiment of the invention includes a biocompatible frame mounted in supporting relationship to the membrane and defining an opening for introducing the bioactive agent into the enclosed space. The frame has greater porosity than the membrane.

Abstract: Multiple use universal connector designed for use in various containers having a fluid port for accessing to the content of the container or for transferring fluid into the container. The multiple use universal connector incorporates a diaphragm capable of being penetrated repeatedly by an access means such as a luer connector or a syringe having a sharp or blunt cannula for fluid communication between the content of the container and the access means. The multiple use universal connector re-seals itself after being penetrated and the access means removed therefrom.

Abstract: A temperature-controlled container for transporting biologic tissue and human skin is set out wherein an outer insulated container houses a power source, a thermostat means, a heating means, a power source and interior container along with a retention means for holding the sample in place and a lid that interlocks with the open annular area by a T-shaped friction plug. The thermostat means may be a microchip and heating element so that the sample and interior temperature does not vary from a given temperature parameter.

Abstract: A temperature-controlled container for transporting biologic tissue and human skin is set out wherein an outer insulated container houses a power source, a thermostat means, a heating means, a power source and interior container along with a retention means for holding the sample in place and a lid that interlocks with the open elongated chamber area by a T-shaped friction plug. The thermostat means may be a microchip and heating element so that the sample and interior temperature does not vary from a given temperature parameter. A eutectic pack which is a solid at room temperature and experiences a phase change to the liquid state at temperatures exceeding room temperature is provided to insure that a minimal super-ambient temperature is maintained.

Abstract: Universal connector designed for use in various containers having a fluid port for access to the content of the container or for transferring fluid into the container. The universal connector incorporates an elastomeric membrane capable of being ruptured by an access means such as a luer connector or a syringe having a sharp or blunt cannula for fluid communication between the content of the container and the access means.

Abstract: A tampon reminder in the form of an adhesive sticker is disclosed. The user can remover the sticker and apply it to the users body, clothing, or a suitable object where it will serve to remind the user that the tampon is in use. The disclosed invention prevent tampons from being inadvertently left in place for an excessive time.

Abstract: The invention concerns a multilayer polymer film and a multichamber bag, whose bag chambers are formed by seams in the outer border zone and by at least one seam in the chamber separation zone, whereby the seams are formed from the polymer materials facing the chambers. The polymer materials facing the chambers are inseparably sealed together in the outer border zone and sealed together in the chamber separation zone such that the seam is separable with a force which lies in the range from 5 to 20 N. The different strength of the bond from the sealing process is obtained by varying sealing temperatures.

Abstract: A dual-filled twin bag, a packaging including the twin bag, and a method for forming the packaged twin bags are provided. Each of two bags, a solution bag (10) and a drain bag (12) for a system used for a peritoneal dialysis procedure, are filled, at least partially, with a solution (14). A tubing set (16) connects the two filled bags (10,12) and may also be filled with solution (14) which is added to the bags (10,12) and the tubing set (16) during the manufacturing process. The tubing set (16) is sandwiched between the solution bag (10) and the drain bag (12) and subsequently packaged in an overpouch (24). The method for forming the package including the bags filled with solution is simplified and the overall package size is reduced due to the sandwiched tubing set (16) between the solution bags (10,12) and the provision of solution in both bags (10,12).

Abstract: A packaging for goods, such as, for example, tablets, capsules or the like, is suggested which is simple to produce and can be handled without problem, comprising a packaging lower part and a cover film, wherein the goods are arranged individually between the packaging lower part and the cover film and enclosed by them, wherein the cover film comprises a pull-off layer and a push-through layer which are designed such that first of all the pull-off layer can be detached from the packaging in sections and the goods then removed individually by being pushed through the push-through layer, wherein the pull-off layer is peelably connected to the push-through layer, wherein the push-through layer is connected to the lower part by means of a sealing layer and wherein the push-through layer is produced on a polymer basis.

Abstract: Methods, compositions, and compounds for modulating the activity of an endothelin peptide are provided. The methods use compositions that contain compounds of formula (I): ##STR1## where X and Y are selected from groups that include O, S, and NH; and Ar.sup.1, Ar.sup.2 and Ar.sup.3 are independently selected from substituted or unsubstituted groups that include 5 to 6 membered aryl groups and heteraryl groups that contain one or two heteroatom(s). The methods are effected by contacting endothelin receptors with one or more of the compounds or with compositions containing one or more of the compounds prior to, simultaneously with, or subsequent to contacting the receptors with an endothelin peptide.

Abstract: A method and device for organizing, storing, instructing, and coordinating the combined use of aerosol medications for the treatment of disorders including respiratory tract disorders for the purpose of reducing medication error and increasing therapeutic compliance.

Abstract: This invention provides a method for inhibiting adsorption of container-derived contaminants on a powdery or solid drug which comprises establishing a lower alcohol vapor phase within a container made, at least in part, of rubber or a plastic material. The method inhibits adsorption of container-derived substances on a drug to preclude development of insoluble particulate matter owing to said adsorption in an aqueous solution prepared extemporaneously without causing loss of the drug and avoiding the toxic effect of decomposition or degradation of the drug, thus insuring a long-term trouble-free stable shelf-life of the drug.

Abstract: Packaging for medicaments such as blister packs contain a plurality of recesses which hold contents. A lidding foil closes off the packaging and protects the contents. The contents such as tablets are pushed through the lidding foil whereupon the lidding foil breaks. The lidding foil features at least one conductive strip and the medicament packaging can be connected to a computer. On pushing the contents through the lidding foil, the lidding foil breaks and the computer recognizes the impulse emitted as a result of this action. The conductive strips contain, as current carrying fraction, an SnO.sub.2 /SbO.sub.3 hydroxide mixture on a mica substrate.

Abstract: A method and device for organizing, storing, instructing, and coordinating the combined use of aerosol and oral medications for the treatment of disorders including respiratory tract disorders for the purpose of reducing medication error and increasing therapeutic compliance.

Abstract: A pharmaceutical dispensing container which holds multiple dosage units for aiding in the compliance in the eradication/treatment for Helicobater pylori and subsequent/related gastric maladies in relation to said bacterial infection using a repetative dosage regimen for a treatment period of sufficient duration to mitigate said bacterial infection formatted in such a way to gain optimal ease of compliance resulting in improved outcome of treatment. Dosage units may be antibiotic, anti microbial, or symtomatic relief agents in any combination.

Abstract: This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 3-benzyl-benzofurans which are .alpha.-substituted with ether, thioether, amino, hydrazino, cyano or halo that are useful for the treatment of the various medical indications associated with post-menopausal syndrome, as well as estrogen dependent diseases including cancer of the breast, uterus and cervix. The present invention further relates to intermediate compounds and processes useful for preparing the pharmaceutically active compounds of the present invention, and pharmaceutical compositions.

Abstract: A transdermal drug delivery device involving a carrier containing a dissolved drug. The device also involves a desiccant package that is inert to the carrier, permeable to water vapor, and defines a desiccant compartment containing a desiccant. The device also involves water vapor impermeable product package that contains the carrier and the desiccant package.

Abstract: This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 3-benzyl-benzofurans which are .alpha.-substituted with ether, thioether amino, cyano or halo that are useful for the treatment of the various medical indications associated with post-menopausal syndrome, as well as estrogen dependent diseases including cancer of the breast, uterus and cervix. The present invention further relates to intermediate compounds and processes useful for preparing the pharmaceutically active compounds of the present invention, and pharmaceutical compositions.

Abstract: The present invention relates to a packaging material for reduced transfer from a package to its content of substances causing undesirable taste and/or hazardous substances, this reduction being due to the packaging material containing a hydrophobic zeolite. More specifically, the invention concerns paperboard, in which case the substances causing undesirable taste mainly are naturally occurring extractive substances, oxidation products thereof and, to a lesser extent, the paper chemicals present. Further, the presence of a hydrophobic zeolite in the paperboard enhances the water-repellent (hydrophobic) capacity. Also, the present invention concerns a method for production of a packaging material of paper, board or paperboard by forming and dewatering a suspension of lignocellulose-containing fibres, where the dewatering takes place in the presence of a hydrophobic zeolite.

Abstract: A sensor dispensing instrument is adapted to receive a generally circular sensor pack containing a plurality of blood glucose sensors. Each of the sensors are disposed in sensor cavities, each of which is in fluid communication with a corresponding desiccant cavity and has a support wall that assists in directing the sensor as its being ejected from the cavity. The sensor pack is loaded on an indexing disk in the instrument such that when a slide actuator on the instrument is moved toward a testing position, a feed mechanism engaged by the slide actuator moves a knife blade thereon toward one of the sensor cavities. The knife blade pierces a portion of a foil covering the sensor cavity and engages the sensor disposed in the cavity to thereby eject the sensor from the sensor cavity.

Abstract: System employing a sterile medical solution containing glucose or glucose polymers, for example nutritional solutions or solutions for peritoneal dialysis, whereby the majority of the solution is packed in a first package, while the glucose or the glucose polymers are separately packed in a second package, whereafter the two packages are heat sterilized. The content of the glucose or glucose polymers in the second package is maintained above 10% by weight, preferably above 20% by weight and most preferably in the order of 40% by weight in order to reduce or totally eliminate the breakdown of glucose. The medical solution after sterilization, mixing and diluting to 1.5% glucose content has an absorbency caused by breakdown products from glucose at 228 nm less than 0.35 and preferably in the order of 0.20 or lower. The medical solution is also defined in that after sterilization, mixing and dilution to 1.

Abstract: A port is formed in a thermoplastic container wall by slitting the wall, inserting a thermoplastic tube through the slit, placing a mandrel in the tube, placing opposed dies defining a bore over the sheet and tube, and dielectrically heating the thermoplastic to fuse the tube and sheet. Preferably the bore defined by the dies is of a diameter slightly less than that of the tube, and has an enlarged central area which forms a thickened section of material over the slit.

Abstract: Methods and articles of manufacture are provided for treating disorders of smooth muscle function in organ systems. A treatment element comprises a biocompatible polymer matrix loaded with a neuroactive substance. The device is placed in contact with the targeted organ system in a manner effecting a therapeutic effect on the smooth muscle function of the organ system.

Abstract: A portable medicine carrier and protector for storing and transporting medicine stored in vials. The vials may be of different sizes. The medicine carrier and protector includes a hollow, thin walled medicine carrier. The carrier is substantially filled with a paraffinic hydrocarbon (C14-C18) such as Hexadecane, an alpha olefin (C14-C20), or a material such as Dimethyl Sulfoxide. A cavity is disposed in a top surface of the carrier. The cavity being formed from a plurality of different semi-circular compartments. Each of the compartments has a different cross-sectional radius. This allows the carrier to accept medicine vials of differing sizes. A plurality of solid ribbed members are disposed transversely in the cavity, so as to prevent direct contact between the carrier and the medicine vials.

Abstract: A hemostatic tampon kit including an oval-shaped tampon adopted for easy insertion into the nasal cavity by a layman, composed of a compressed synthetic sponge adapted to expand upon contact with an aqueous fluid, the tampon includes a string attached thereto for anchoring to a nasal bandage placed over the nostrils of the user which includes an absorbent drip pad and an attachment element on the bandage for engaging and holding the tampon string. A sealable container of liquid vasoconstrictive medication for wetting and expanding the tampon and a container of anti-bacterial ointment for lubricating the tampon during insertion.

Abstract: A treatment delivery system which uses a flexible plastic outer container and a smaller, readily burstable, thin film plastic inner container fixedly positioned in the outer container. The inner container contains a treatment solution and a dry foam appliance is loosely placed within the inner container. When the inner container is burst by applying pressure to the outer container at a position which corresponds to the position of the inner container therein, the treatment solution comes into contact with the foam appliance so as to be absorbed by, and to wet the appliance. The wetted foam appliance can then be removed from the outer container for use.

Abstract: The present invention relates to a method for treating hypertension or glaucoma in the eye comprising contacting the surface of the eye with a therapeutic amount of a 15-deoxyprostaglandin derivative of the formula (I): ##STR1## in which ##STR2## is a 5 membered ring which is selected from a group consisting of ##STR3## R.sup.1 is hydrogen or lower alkyl; R.sup.2 is C.sub.6 -C.sub.12 alkyl, C.sub.6 -C.sub.12 alkenyl or C.sub.6 -C.sub.12 alkadienyl or a pharmaceutically acceptable salt thereof. The invention also relates to a kit for delivery of a topical solution for treatment of glaucoma which comprises (a) container having a solution including a compound of the formula (I), and (b) means for topical delivery of said solution to the eye in a controlled dosage.

Abstract: Disclosed is an odor-absorbing, non-dusting porous web material and a method of making the same. The web material includes a porous base web (for example, a fibrous base web, such as a non-woven or paper web) having distributed throughout odor-absorbing particulate (such as zeolite). Alkaline salt or alkaline earth oxide particulate, to better effect removal of acidic malodor, desirably also is distributed throughout the base web, in the final product. The odor-absorbing particulate is bound to the base web (e.g., fibers of a fibrous base web) by a binding system, containing a binding agent. The binding system, in the odor-absorbing web materials, is transparent to the odors so as not to substantially effect the ability of the particulate to absorb odor-causing material.

Abstract: A device comprising a solid or powdered concrete admixture contained in a water-soluble container such that when the container and its contents are introduced into a wet mixer and agitated for a period of time, the water-soluble container is dissolved and the contents are released into the wet mixer. A separate water-insoluble receptacle is used to house and store the water-soluble container and its contents. In addition, there is disclosed a method for modifying the properties of a concrete by introducing a pre-weighed amount of solid admixture contained in a water-soluble container into a wet mixer and thereafter agitating the resulting mix.

Abstract: A dispenser for maintaining light sensitive substances utilized in the practice of dentistry shielded from light and providing easy and convenient access by the dentist includes a container and a cover therefor with the cover being hingably attached to the container. The container includes a plurality of recesses for receiving one or more light sensitive substances. The container is provided with structure such as a finger hold on the bottom or an elastic band for maintaining the container on one or more digits of a hand and the cover is provided with a ring or other suitable structure for maintaining the cover in operable engagement with another digit of the hand, such as a thumb, whereby the dispenser may be held in one hand and readily opened and closed to provide easy, quick, convenient access to the light sensitive substances by the dentist.

Abstract: Disclosed are nitrosated and/or nitrosylated phosphodiesterase inhibitors having the formula NOn-PDE inhibitor where n is 1 or 2. The invention also provides compositions comprising such compounds in a pharmaceutically acceptable carrier. The invention also provides a composition comprising a therapeutically effective amount of an phosphodiesterase inhibitor (PDE inhibitor), which can optionally be substituted with at least one NO or NO2 moiety, and one to ten fold molar excess of a compound that donates, transfers or releases nitrogen monoxide as a charged species, i.e., nitrosonium (NO+) or nitroxyl (NO−), or as the neutral species, nitric oxide (NO•) or which stimulates endogenous EDRF production. The invention also provides compositions comprising such compounds in a pharmaceutically acceptable carrier. The invention also provides methods for treating sexual dysfunctions in males and females.