Including Liquid Flow Diversion Patents (Class 210/659)
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Patent number: 11940428Abstract: A preparative liquid chromatograph including an analysis channel (2), an injector (6), a separation column (8), a detector (10), a plurality of fraction collectors (14-1 to 14-n), a switching valve (12) that switches fraction collectors (14-1 to 14-n) to be connected to the outlet of the detector (10) among the plurality of fraction collectors (14-1 to 14-n), and a controller (16) for controlling operations of the plurality of fraction collectors (14-1 to 14-n) and the switching valve (12). In a case where the number of remaining unused collection containers of the fraction collector in use, which is connected to the outlet of the detector, falls below the number of buffers which is an integer of two or more, the controller (16) is configured to switch the switching valve (12) while the fraction collector in use is not performing a peak collection operation.Type: GrantFiled: February 25, 2022Date of Patent: March 26, 2024Assignee: SHIMADZU CORPORATIONInventors: Soichiro Tamaoki, Tomoyuki Yamazaki, Shohei Sato
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Patent number: 11913920Abstract: The invention relates to a method for controlling preparative liquid chromatography, comprising the following steps, at least a part of said steps being implemented by a computer comprising a processor and a display screen coupled to said processor: (a) selecting an analytical liquid chromatography method from among thin layer chromatography (TLC) and high performance liquid chromatography (HPLC), (b) inputting analytical liquid chromatography data obtained by the method selected at step (a) for a product to be purified, (c) accessing a table of separating tools available to the user to implement said preparative liquid chromatography, (d) from said analytical liquid chromatography data and table of available separating tools, selecting an optimal separating tool from said table and computing preparative liquid chromatography operating conditions for said selected separating tool.Type: GrantFiled: April 8, 2019Date of Patent: February 27, 2024Assignee: INTRCHIM S.A.Inventors: Lionel Boch, Didier Charbonneau, Alain Tchapla, Dominique Desquaires, Olivier Mercier, Yann Pourcheresse, Nicolas Quetant
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Patent number: 11912739Abstract: Provided herein are methods of performing chromatography with gamma-irradiated chromatography resin that include providing a chromatography column including a gamma-irradiated chromatography resin; performing a first cycle of chromatography through the column, where the cycle includes exposing the chromatography resin to a denaturing buffer; and performing at least one additional cycle of chromatography through the column. Also provided are integrated, closed or substantially closed, and continuous processes for manufacturing of a recombinant protein that include the use of at least one chromatography column including gamma-irradiated chromatography resin, where the gamma-irradiated chromatography resin is exposed to denaturing buffer during each cycle in the process, and reduced bioburden buffer is used in the process.Type: GrantFiled: August 14, 2020Date of Patent: February 27, 2024Assignee: Genzyme CorporationInventors: Rahul Godawat, Veena Warikoo, Rohan Patil, Konstantin Konstantinov, Venkat Kishore Ryakala, Mahsa Rohani
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Patent number: 11867673Abstract: The present invention relates to method of using spectroscopy for real time measuring of concentration of desired product and using measured data for monitoring and control of chromatography. It develops a method and system for measuring real-time concentration of clarified harvest and that of flow through of loading step of the chromatography and using measured data for determining breakthrough in real-time. The two modes of operation are used viz. first mode (Part A) uses a single near infrared spectroscopy (NIR) flow cell prior to the continuous chromatography column to ensure optimal loading in each cycle based on dynamic binding capacity studies carried out previously with the desired Protein A resin and second mode (Part B) uses two near infrared spectroscopy (NIR) flow cells, one before and one after the column, to detect the breakthrough curve (from 1% breakthrough onwards).Type: GrantFiled: March 20, 2020Date of Patent: January 9, 2024Assignee: Indian Institute of Technology DelhiInventors: Anurag Singh Rathore, Garima Thakur, Vishwanath Hebbi
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Patent number: 11857892Abstract: The invention relates to a method for separating a mixture in a system comprising a plurality of chromatography columns, the method successively comprising, in a cyclical manner, in a given part of the system: a step of collecting a raffinate; a step of injecting the mixture to be separated; a step of collecting an extract; and a step of injecting a mobile phase; the method further comprising: determining, in a node of the system, the history of a variable representing the concentration of at least one species contained in the mixture to be separated; detecting, within said history, a characteristic point between the beginning of a step of collecting the extract and the end of the following step of collecting the raffinate; comparing the position of the characteristic point in relation to a target position; and adjusting the carrier volume of the characteristic point, modifying the position of the characteristic point in order to bring the position of the characteristic point closer to the target position; thType: GrantFiled: November 16, 2018Date of Patent: January 2, 2024Assignee: NOVASEP PROCESS SOLUTIONSInventors: Cedric Prieur, Eric Valery
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Patent number: 11845769Abstract: An anion exchange for separating a plurality of carbohydrates includes a negatively charged substrate particle. A base polymer layer includes a first plurality of quaternary amines. The polyalkylpolyamine polymer layer is covalently attached to the base condensation polymer layer. The polyalkylpolyamine polymer layer includes a polymeric branch structure that includes a second plurality of quaternary amines. A density of the second plurality of quaternary amines increases in a direction away from the base condensation polymer layer. The anion exchange stationary phase does not have a hydroxy group spaced apart from any one of the first or the second plurality of quaternary amines by an ethyl group.Type: GrantFiled: February 15, 2021Date of Patent: December 19, 2023Assignee: Dionex CorporationInventors: Christopher A. Pohl, Jinhua Chen
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Patent number: 11841350Abstract: A dynamic axial compression column is disclosed herein. This dynamic axial column utilized external compression to prevent the creation of end plate space in the column. The dynamic axial column can include a tube defining a first opening, a second opening, and a lumen extending there between. The dynamic axial column can include a first end plate assembly sealing the first opening and movably extending at least partially into the lumen via the first opening, a second end plate assembly sealing the second opening, a plurality of rods extending along the outside of the tube and connecting the first end plate assembly and the second end plate assembly, and a first plurality of compression devices external to the tube and engaging one of the plurality of rods to bias the first end plate assembly towards the second end plate assembly.Type: GrantFiled: March 15, 2022Date of Patent: December 12, 2023Assignee: Bio-Rad Laboratories, Inc.Inventors: Christopher Belisle, Mark A. Snyder
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Patent number: 11835498Abstract: A high throughput gas-chromatography system for analysis of high-molecular weight additives in a polymer material, and an analysis method using same are provided. A high throughput gas-chromatography system is capable of qualitatively and quantitatively analyzing, at the same time, high-molecular weight additives in a polymer, and reducing analysis time by increasing a heating rate and a column maximum temperature.Type: GrantFiled: October 29, 2018Date of Patent: December 5, 2023Inventors: Rin Jang, Mi Kyoung Jin, Moon Ja Nam, Byoung Hyoun Kim
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Patent number: 11828737Abstract: In a preparative liquid chromatograph, a control device for controlling at least operation of a sample injection part includes a holding part for holding a chromatogram-for-setting created in advance for a sample to be analyzed, and an injection program creating part configured to create an injection program that defines timings at which injection operations are executed based on the chromatogram-for-setting, so that, in the case where the number of injections in a multiple injection mode is set, a peak of a chromatogram of the sample to be analyzed injected in each injection operation does not overlap a peak of a chromatogram of the sample to be analyzed injected in another injection operation.Type: GrantFiled: April 5, 2017Date of Patent: November 28, 2023Assignee: Shimadzu CorporationInventors: Soichiro Tamaoki, Tsutomu Okoba, Takayuki Iriki, Shiori Ueda
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Patent number: 11782034Abstract: A fraction collector control device includes a peak designation part that displays a chromatogram for setting and requires a user to select at least one peak in the chromatogram for setting, a parameter extraction part that extracts, as a parameter, a signal level and/or a slope at a start point and an end point of each peak designated by a user, and a threshold candidate generation part that generates, based on the parameter extracted by the parameter extraction part, a threshold candidate usable as a common threshold for detecting start points of all peaks designated by a user and a common threshold for detecting end points of all peaks designated by a user.Type: GrantFiled: March 7, 2017Date of Patent: October 10, 2023Assignee: Shimadzu CorporationInventors: Soichiro Tamaoki, Tsutomu Okoba, Takayuki Iriki, Shiori Ueda
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Patent number: 11733215Abstract: In a preparative liquid chromatograph, a control device for controlling at least operation of a sample injection part includes a holding part for holding a chromatogram-for-setting created in advance for a sample to be analyzed, and an injection program creating part configured to create an injection program that defines timings at which injection operations are executed based on the chromatogram-for-setting, so that, in the case where the number of injections in a multiple injection mode is set, a peak of a chromatogram of the sample to be analyzed injected in each injection operation does not overlap a peak of a chromatogram of the sample to be analyzed injected in another injection operation.Type: GrantFiled: April 5, 2017Date of Patent: August 22, 2023Assignee: Shimadzu CorporationInventors: Soichiro Tamaoki, Tsutomu Okoba, Takayuki Iriki, Shiori Ueda
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Patent number: 11725191Abstract: Methods for continuously inactivating virus during manufacture of a biological product are provided. The methods include steps of (1) combining (a) a composition including a biological product, and (b) a composition including a virus-inactivation reagent, to obtain (c) a treatment composition having a predetermined property for inactivation of a virus, (2) confirming that the treatment composition exhibits the predetermined property, (3) transferring the treatment composition to a treatment vessel that includes an inlet, an outlet, and a static mixer, the transferring occurring at the inlet, (4) incubating the treatment composition in the treatment vessel at a predetermined temperature while the treatment composition flows at a predetermined rate and contacts the static mixer, and (5) collecting the treatment composition from the treatment vessel at the outlet, wherein steps (1) to (5) are carried out continuously. Apparatuses and systems including such a treatment vessel are also provided.Type: GrantFiled: August 23, 2019Date of Patent: August 15, 2023Assignee: Boehringer Ingelheim International GmbHInventors: Jonathan Coffman, Jeff Goby, Scott Godfrey, Raquel Orozco, Jens Holger Vogel
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Patent number: 11661635Abstract: A method for purifying a mixture in a multicolumn chromatography system. The method successively and cyclically collects a raffinate, injects the mixture to be separated, collects an extract, and injects eluent. The mixture to be separated contains fructose and has a dry matter mass concentration of 45 to 55%. The method is carried out at a temperature of 50 to 62° C.Type: GrantFiled: April 22, 2019Date of Patent: May 30, 2023Assignee: NOVASEP PROCESS SOLUTIONSInventors: Teddy Ebran, Guillaume Thibault
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Patent number: 11630088Abstract: Automation of the collection and reinjection of a sample into a large number of containers is made possible without increasing the size of a liquid handler itself.Type: GrantFiled: March 29, 2021Date of Patent: April 18, 2023Assignee: Shimadzu CorporationInventor: Tomoyuki Yamazaki
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Patent number: 11467137Abstract: When a flow path switch valve is in a first flow path state, an aqueous solvent supplied by an aqueous solvent supplier is guided to a first flow path, and a pH of the aqueous solvent is measured by a pH meter provided in the first flow path. When the flow path switch valve is in a second flow path state, the aqueous solvent supplied by the aqueous solvent supplier is guided to a second flow path. A sample to be analyzed is supplied by a sample supplier at a position farther downstream than the flow path switch valve. The solvent that has passed through the second flow path and the sample supplied by the sample supplier are guided to a separation column. The sample that has passed through the separation column is detected by a detector.Type: GrantFiled: January 21, 2021Date of Patent: October 11, 2022Assignee: Shimadzu CorporationInventor: Hiroshi Ohashi
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Patent number: 11447716Abstract: A system and method for extracting essential oils is provided. One embodiment comprises an extractor assembly with an extractor cover, an extractor container, and an extractor assembly base, wherein the extractor container is secured between the extractor cover and the extractor assembly base during an extraction process; a bowl cover assembly with a collection bowl, and a bowl cover assembly base, wherein the collection bowl is secured between the extractor assembly base and the bowl cover assembly base during the extraction process; and a canister compression holder assembly, wherein a cannister containing a solvent is secured within the canister compression holder assembly during the extraction process. A solvent that is released from the cannister passes into the extractor container that contains matter that is to have essential oils extracted therefrom. The extracted oils exits the extractor assembly base into the collection bowl that collects the solvent with the essential oils.Type: GrantFiled: May 21, 2020Date of Patent: September 20, 2022Inventor: Mark Herwig
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Patent number: 11415563Abstract: In an LC/MS/MS analysis: injecting a sample into a passage leading to a column group provided in a liquid chromatograph, the column group including a plurality of columns serially connected to each other and packed with different kinds of packing materials; supplying an eluant to one or a plurality of columns including a column located most downstream, to separate a portion of the target components in the sample in the one or plurality of columns, and sequentially elute those components from the most downstream column to perform mass spectrometry; and supplying a different eluant to one or a plurality of columns including the most downstream column, to separate at least a portion of the target components which stayed uneluted in the one or plurality of columns in the first analysis step, and sequentially elute those components from the most downstream column to perform mass spectrometry.Type: GrantFiled: April 13, 2017Date of Patent: August 16, 2022Assignees: SHIMADZU CORPORATION, NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIESInventors: Toshikazu Minohata, Jun Watanabe, Shoji Nakayama
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Patent number: 11300548Abstract: A liquid chromatographic (LC) system is introduced which comprises at least one fluidic stream, the fluidic stream comprising a sample-injection valve, a trap-bypass-selection valve, a column-bypass valve, a load-elute valve and a trap-selection valve. Also, a liquid chromatographic (LC) system is introduced which comprises at least one fluidic stream. The fluidic stream comprises a first substream and a second substream. The first substream comprises a first sample-injection valve, a load-elute valve and a trap-selection valve. The second substream comprises a second sample-injection valve and a column-bypass valve. The fluidic stream further comprises a trap-LC substream transfer valve and a substream-selection valve. The LC systems provide a broad choice of chromatographic options and modes and enable to flexibly and rapidly switch between them.Type: GrantFiled: June 4, 2020Date of Patent: April 12, 2022Assignee: Roche Diagnostics Operations, Inc.Inventor: Adrian Sievers-Engler
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Patent number: 11226274Abstract: Systems and methods for concentrating an analyte preparatory to analysis thereof include processing the effluent of an analyte concentrator to produce an eluent for eluting an analyte retained in the same or separate concentrator, and systems implementing the same. The analyte concentrator system connects the effluent outlet of an analyte concentrator column to an eluent generation module such that the substantially analyte-free effluent discharged from the analyte concentrator column passes fluidly into the eluent generation module. Eluent generated from the substantially analyte-free effluent in the eluent generation module is likewise substantially free of the analyte. The systems and methods can minimize and/or (substantially) eliminate background signal during analysis of the concentrated analyte.Type: GrantFiled: February 12, 2016Date of Patent: January 18, 2022Assignee: DIONEX CORPORATIONInventor: Kannan Srinivasan
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Patent number: 11154795Abstract: The invention relates to a method for chromatographic separation, comprising at least one step of elution of species held on a stationary phase by means of an eluent, followed by a step of moving the eluent in contact with the stationary phase by means of a compressed gas. Preferably, the movement step takes place after a step of elution of the product(s) of interest and/or after a step of regeneration of the stationary phase.Type: GrantFiled: October 21, 2016Date of Patent: October 26, 2021Assignee: NOVASEP EQUIPMENT SOLUTIONSInventor: Jérôme Boni
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Patent number: 10948466Abstract: An in-line electrolytic reagent concentrator device that circumvents the need for additional pumps and supplies of reagents to support operation of a carbonate or ammonia removal device. The device generates regenerant solutions as strong as, or even stronger, than commercially recommended regenerant solutions. The device may also regenerate eluent solutions so as to reduce the frequency of eluent maintenance and replacement in ion chromatography systems.Type: GrantFiled: March 3, 2017Date of Patent: March 16, 2021Inventors: Kannan Srinivasan, Mrinal Sengupta, SM Rahmat Ullah
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Patent number: 10913906Abstract: The present invention relates to a process for the separation of aromatic hydrocarbons from a hydrocarbon feed stream comprising contacting a hydrocarbon feed stream with a solvent for aromatics (aromatics solvent) to provide an aromatics-laden solvent stream and subjecting the aromatics-laden solvent stream to solvent regeneration to provide regenerated aromatics solvent and an aromatics stream.Type: GrantFiled: December 12, 2016Date of Patent: February 9, 2021Assignee: SABIC GLOBAL TECHNOLOGIES B.V.Inventors: Kokil Jain, Christoph Dittrich, Kumar Prashant
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Patent number: 10416137Abstract: An electrodialytic device for ion chromatography, including aspects functioning as an eluent suppressor device and aspects functioning as an eluent generator device. In general, the device includes a monolithic block of ionomeric polymer material having (1) a first channel with an inlet port, an outlet port, and an active length of exposed polymer material disposed therebetween, (2) a second channel having an inlet port, an outlet port, and an active length of exposed polymer material disposed therebetween, (3) a first and second at-least-partially exposed electrodes positioned in electrical communication with the second channel, with the second electrode disposed, at least in part, across the second channel from the first electrode. A current flowing between the electrodes will drive an electrodialytic migration of ions between the active lengths, from an eluent stream in the case of a suppression device or into an eluent stream in the case of a generator device.Type: GrantFiled: September 7, 2016Date of Patent: September 17, 2019Assignee: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEMInventors: Purnendu K. Dasgupta, Weixiong Huang
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Patent number: 10005006Abstract: The invention relates to a method for setting a gradient delay volume GDV of a liquid chromatography system for a chromatography run in liquid chromatography, in particular a high-performance liquid chromatography system, in which a desired value GDVtarget of a gradient delay volume of the liquid chromatography system is ascertained or predefined and, if the value GDVtarget deviates from a specific fixed value GDVactual of a liquid chromatography system, this value GDVtarget is set in a range 0??GDV=GDVtarget?GDVactual?Vmax of a volume of a volume adjustment device 5. Furthermore, the invention relates to an automatic sampler for carrying out such a method.Type: GrantFiled: March 18, 2015Date of Patent: June 26, 2018Assignee: DIONEX SOFTRON GMBHInventors: Hermann Hochgraeber, Thomas Wachinger
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Patent number: 9522862Abstract: A simulated moving bed separator and methods for isolating a desired component are provided. A method includes removing an extract from an extract bed of the simulated moving bed separator, where the extract includes the desired component, and where the simulated moving bed separator includes a plurality of adsorbent beds circularly coupled together. The simulated moving bed separator also includes a distributor and a plurality of conduits fluidly coupling the distributor to the adsorbent beds. The adsorbent beds include the extract bed and a secondary flush bed downstream from the extract bed. A secondary flush conduit is flushed with a secondary flush fluid while removing extract from the extract bed, where the secondary flush conduit fluidly couples the secondary flush bed with the distributor. The flush fluid includes the extract.Type: GrantFiled: June 30, 2014Date of Patent: December 20, 2016Assignee: UOP LLCInventor: Robert Edward Sanders
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Patent number: 9416880Abstract: A rotary metering valve assembly includes a stationary body plate having a first contact surface. Also included is a valve plate having a second contact surface disposed in contact with the first contact surface of the stationary body plate, wherein the valve plate is configured to rotate relative to the stationary body plate. At least one of the first contact surface and the second contact surface comprises a surface flatness of less than about 2.4 ?m (about 93 ?in) and a surface roughness of at least about 0.2 ?m (about 8 ?in).Type: GrantFiled: February 21, 2014Date of Patent: August 16, 2016Assignee: HAMILTON SUNDSTRAND CORPORATIONInventors: Kevin M. Rankin, Peter M. Ballard, Todd Haugsjaahabink, Glen A. Pruden
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Patent number: 9260677Abstract: The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product from a feed mixture, which process comprises the steps of: (i) purifying the feed mixture in a first separation step in a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous organic solvent, to obtain an intermediate product; and (ii) purifying the intermediate product obtained in (i) in a second separation step using a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous organic solvent, to obtain the PUFA product; wherein (a) the first and second separation steps are carried out sequentially on the same chromatography apparatus, the intermediate product being recovered between the first and second separation steps and the process conditions in the chromatography apparatus being adjusted between the first anType: GrantFiled: July 6, 2012Date of Patent: February 16, 2016Assignee: BASF Pharma Callanish LimitedInventors: Adam Kelliher, Angus Morrison, Anil Oroskar, Rakesh Vikraman Nair Rema, Abhilesh Agarwal
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Patent number: 9180387Abstract: The invention concerns a method for separating fractions of a mixture to be separated, in a device (1) comprising: several chromatography columns (21, 22, 23,) mounted in series; an open separation loop comprising in input a point for injecting (6) eluent in one of the columns and in output a point for drawing (8) a fraction of the mixture. The method includes the following steps: batch injection of the mixture to be separated in the open separation loop (4); collecting at least two fractions; offsetting at least one column of the eluent injecting and fraction drawing points (6, 8) of the separation loop (4). The invention also concerns a device for separating fractions of a mixture to be separated.Type: GrantFiled: July 25, 2006Date of Patent: November 10, 2015Assignee: NOVASEP PROCESSInventors: Eric Valery, Olivier Ludemann-Hombourger
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Patent number: 9005990Abstract: The present invention concerns a method of purifying colistin using reverse phase chromatography, wherein loading a column with colistin base in acetic acid and high ethanol concentration and eluting with low ethanol concentration is performed.Type: GrantFiled: September 29, 2010Date of Patent: April 14, 2015Assignee: Xellia Pharmaceuticals APSInventors: Torben Koch, Carsten Overblle Petersen
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Patent number: 8999172Abstract: A system is provided for removal of undesirable dissolved substances from solutions containing two or more dissolved substances to produce one or more new solutions suitable for beneficial use. The system utilizes amphoteric media in a treatment cycle where dissolved substances from the concentrated solution are first adsorbed by the media and subsequently rinsed with water to desorb and collect the dissolved substances sequentially into dilute effluent streams the substances are either aggregated or segregated based upon differences in relative concentrations of dissolved substances that is a result of differences in the affinity of the media for the dissolved substances. One or more of the dilute effluent streams are treated with a desalination process to recover water for media rinse and to concentrate the separated dissolved substances to facilitate beneficial use or disposal.Type: GrantFiled: December 13, 2011Date of Patent: April 7, 2015Assignee: Global Water Advisors, Inc.Inventor: Joseph E. Zuback
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Patent number: 8992778Abstract: Embodiments of the present invention feature methods and apparatus for performing chromatographic separations. The invention feature methods and control means in the form of computer programs and software that control the formation of a concentration gradient at two or more total flow rates, with an elution period occurring in a slow flow rate and at least other portions of the gradient occurring during a fast total flow rate.Type: GrantFiled: February 5, 2007Date of Patent: March 31, 2015Assignee: Waters Technologies CorporationInventor: Hongji Liu
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Patent number: 8956535Abstract: A single pass simulated moving bed apparatus and methods are described for continuously separating a target molecule from a liquid mixture, using a simulated moving bed system. The simulated moving bed system includes a plurality of filter cartridge modules in serial fluid communication. Each filter cartridge module includes a volume of stationary phase particulates adjacent a porous substrate layer. The volume of stationary phase particulates has a bed height of less than 1 centimeter.Type: GrantFiled: July 11, 2008Date of Patent: February 17, 2015Assignee: 3M Innovative Properties CompanyInventors: Kelly J. Gibbens, Masayuki Nakamura, Kannan Seshadri, Andrew W. Rabins, Larry J. Carson, Robert T. Fitzsimons, Jr.
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Publication number: 20140284279Abstract: The present invention provides an apparatus that can be used to connect a flash chromatography instrument to a fraction collector and a mass detector to perform mass-directed flash chromatography.Type: ApplicationFiled: March 24, 2014Publication date: September 25, 2014Applicant: BIOTAGE ABInventors: Anders WARNGREN, Anders WESSMAN, Erik HALLIN, Lars JOHNSSON
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Publication number: 20140251913Abstract: A chromatography system for separation of a biopolymer is described, comprising at least one feed tank, at least one hold tank, at least one elution buffer tank, at least one eluate tank, at least two packed bed chromatography columns and at least one pump and at least one outlet detector both fluidically connected to said each packed bed chromatography column, wherein the feed tank, the hold tank(s), the elution buffer tank and the eluate tank are each fluidically connected to the packed bed chromatography columns via a system of valves.Type: ApplicationFiled: May 19, 2014Publication date: September 11, 2014Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: KAROL LACKI, MARTIN HALL
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Patent number: 8821732Abstract: A device (SMB) for separation by simulated moving bed adsorption comprises a plurality of elementary zones Zi in series operating in a closed loop, each of said zones comprising, between two successive fluid injection or extraction points, a unique bed Li of adsorbant solid with volume VAi and a non-selective free volume Vi, in which the majority of the zones are ordinary elementary zones each having an identical volume VA of the same adsorbant S, and a substantially identical non-selective free volume equal to V; the device also comprises at least one particular elementary zone Z0, termed the particular elementary zone, comprising a non-selective free volume V0 which is greater than V, and a unique bed L0 of adsorbant S0 with volume VA0 which is less than VA, S0 having a volume adsorption capacity C0 which is greater than that, C, of S, such that the overall adsorption capacity C0×VA0 of Z0 is closer to the overall adsorption capacity C×VA of each of the ordinary elementary zones than the overall adsorptionType: GrantFiled: December 1, 2008Date of Patent: September 2, 2014Assignee: IFP Energies NouvellesInventors: Philibert Leflaive, Tom Frising, Damien Leinekugel-Le-cocq, Gerard Hotier
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Patent number: 8802913Abstract: A process for separating a product from a multicomponent feedstream to an adsorption apparatus or system is described. The apparatus or system may comprise a moving-bed or a simulated moving-bed adsorption means. The product comprises at least one organic compound, such as an aryl compound with alkyl substitutes. In embodiments the conduits used to supply the feedstream to the apparatus or system are flushed with media of multiple grades. The improvement is a more efficient use of the desorbent. In embodiments the process achieves improvements in one or more of efficiency of adsorption separation, capacity of adsorption apparatus systems, and purity of product attainable by adsorption process.Type: GrantFiled: October 3, 2013Date of Patent: August 12, 2014Assignee: ExxonMobil Chemical Patents Inc.Inventor: John R. Porter
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Patent number: 8741146Abstract: A method for the recovery of acids and other materials from hydrometallurgic process solutions comprising processing said solutions utilizing a simulated moving bed chromatographic method to produce at least two product streams.Type: GrantFiled: February 28, 2012Date of Patent: June 3, 2014Assignee: Amalgamated Research LLCInventors: Michael M. Kearney, Michael W. Mumm, Lawrence Velasquez, William Jacob, IV
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Patent number: 8741134Abstract: In a preferred embodiment, a sample container storage part for storing a number of sample containers S, a nozzle for dropping a sample component separated and supplied by an LC and an additive liquid such as digestive fluid supplied from another liquid supplying part to the sample container S, a carrying mechanism for carrying and positioning the sample container at an arbitrary position under the nozzle, and a second nozzle, serving as a suction/injection mechanism, for sucking in the fractionated/collected sample component and injecting the sample component to another LC. The carrying mechanism provides a rotation mechanism. The carrying mechanism rotates over 180 degrees and carries the sample container S completed with fractionating/collecting to the position of the second nozzle, and the sample is sucked in by the second nozzle and injected to the LC of next stage.Type: GrantFiled: December 20, 2005Date of Patent: June 3, 2014Assignee: Shimadzu CorporationInventors: Shuzo Maruyama, Yosuke Iwata
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Patent number: 8722955Abstract: A device (SMB) for separation by simulated moving bed adsorption comprises a plurality of elementary adsorption zones Zi in series operating in a closed loop, and at least one singular adsorption zone with a dead volume which is greater than the adsorption zones Zi, the solid adsorbant of said singular adsorption zone having a granulometry which is lower than that of the solid adsorbant of the ordinary adsorption zones.Type: GrantFiled: March 24, 2009Date of Patent: May 13, 2014Assignee: IFP Energies NouvellesInventors: Gerard Hotier, Tom Frising, Philibert Leflaive, Damien Leinekugel le Coco
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Patent number: 8679332Abstract: A method and apparatus for monitoring and controlling the nano-scale flow rate of fluid in the operating flow path of a HPLC system without relying on a nano-scale sensor in the operating flow path. A main flow sensor is disposed in the main flow path between the pump and a flow-divider. A waste flow sensor is disposed in the waste flow path downstream of the splitter. The output signal of the waste flow sensor is subtracted from the output signal of the main flow sensor in a difference circuit. The difference signal is divided by the output signal from the main flow sensor in a divider circuit. The output of the divider circuit represents an empirical split ratio of the flow-divider and is independent of media composition.Type: GrantFiled: December 19, 2007Date of Patent: March 25, 2014Assignee: Waters Technology CorporationInventors: Geoff C. Gerhardt, Keith Fadgen
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Patent number: 8679333Abstract: A method and apparatus for monitoring and controlling nano-scale flow rate of fluid in the operating flow path of a HPLC system provide fluid flow without relying on complex calibration routines to compensate for solvent composition gradients typically used in HPLC. The apparatus and method are used to correct the flow output of a typical, analytical-scale (0.1-5 mL/min) HPLC pump to enable accurate and precise flow delivery at capillary (<0.1 mL/min) and nano-scale (<1 ?L/min) HPLC flow rates.Type: GrantFiled: January 25, 2010Date of Patent: March 25, 2014Assignee: Waters Technologies CorporationInventors: Geoff C. Gerhardt, Joseph A. Luongo
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Publication number: 20140061133Abstract: A method for chromatographically separating analytes of a liquid sample comprises: (i) providing the sample in a conduit; (ii) providing a solvent for the sample; (iii) causing the solvent to simultaneously flow into the conduit so as to expel the sample from the conduit and flow into and through a second conduit so as to exit said second conduit; (iv) simultaneously providing the expelled sample and the exited solvent to a mixing tee-junction such that the expelled sample and the exited solvent mix thereat; (v) providing the mixture of the expelled sample and the exited solvent to a chromatographic column such that the analytes are transferred to the column and are chromatographically separated therein under the influence of a flow of the solvent, or a different solvent or a mixture of solvents.Type: ApplicationFiled: August 31, 2012Publication date: March 6, 2014Inventor: Joseph Lewis HERMAN
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Patent number: 8658040Abstract: The invention relates to a chromatographic process for substance separation in the context of the preparation of chemicals such as, for example, chiral pharmaceuticals, isomers or biomolecules on the small-scale and production scale, based on Simulated Moving Bed (SMB=countercurrent chromatography) technology.Type: GrantFiled: August 12, 2009Date of Patent: February 25, 2014Assignee: Bayer Intellectual Property GmbHInventors: Jochen Strube, Karsten-Ulrich Klatt, Gerhard Noeth, Joern Greifenberg, Sebastian Bocker, Heinz Kansy, Peter Jahn, Berthold Justen
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Patent number: 8621915Abstract: The invention provides improved methods and apparatus for multidimensional analysis, especially for multidimensional liquid chromatography. Methods and apparatus for the quantitative determination of one or more components comprised in a sample mixture are described. Methods and apparatus of the invention typically allow accurate quantitative determination of more components of the mixture than prior multidimensional methods. The invention is particularly useful for, but is not limited to the analysis of complex mixtures of peptides and proteins.Type: GrantFiled: May 27, 2008Date of Patent: January 7, 2014Assignee: Waters Technologies Corp.Inventor: Hongji Liu
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Patent number: 8608960Abstract: Provided are methods of separating an immunoreactive compound from at least one immaterial component, using a simulated moving bed (“SMB”) system and a SMB apparatus for use in these methods. Also provided are purified immunoreactive compounds prepared using the SMB methods and apparatus and methods of treatment with the purified immunoreactive compounds.Type: GrantFiled: May 21, 2007Date of Patent: December 17, 2013Assignee: Biogen Idec Inc.Inventors: Jorg Thommes, Alan M. Sonnenfeld, John P. Pieracci, Lynn Conley, Marc Bisschops, Maarten Pennings
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Publication number: 20130319945Abstract: A device for field flux fractioning comprises a sensor to determine the presence of particles in a liquid and a channel impermeable for particles and permeable for liquid. A pump conveys the liquid to first and second paths to the channel, where the second path connects in a first position to the pump outlet and in a second position to the sensor. An injection device injects a sample comprising particles into the liquid flowing through the first path. A distribution device distributes the flow volume conveyed by the pump in a first position at a predetermined ratio to the first and second paths. A control device comprises a valve and a measuring device to measure the flow volume. The valve controls the flow volume in the first path in consideration of the measuring device measurement and the pump conveys the liquid in a flow volume, which can be precisely dosed.Type: ApplicationFiled: September 22, 2011Publication date: December 5, 2013Applicant: WYATT TECHNOLOGY EUROPE GMBHInventors: Ulrich Rosch, Christoph Johann
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Patent number: 8586350Abstract: A high-purity fragment is obtained by a simple mechanism and method for separating and purifying a nucleic acid, particularly fragment DNA, extremely efficiently and with a high reproducibility, wherein elution with a high-concentration salt is not performed and necessity of elution and purification is eliminated. This mechanism is a mechanism for purifying a nucleic acid, particularly fragment DNA using a monolith structure formed with glass or silica, specifically, an integral porous body having an open structure with pores that communicate the upper end with the lower end, wherein through-pores corresponding to nucleic acid sizes of 35 bp (mer) to 100 Kbp (mer) are provided.Type: GrantFiled: February 12, 2004Date of Patent: November 19, 2013Assignee: GL Sciences IncorporatedInventors: Osuman Toujou, Masayoshi Ohira, Kensuke Okusa, Nobuo Seto, Masahiro Furuno
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Publication number: 20130248451Abstract: A chromatography system for separation of a biopolymer is described, comprising at least one feed tank, at least one hold tank, at least one elution buffer tank, at least one eluate tank, at least two packed bed chromatography columns and for each packed bed chromatography column at least one pump and at least one outlet detector both connected to said each packed bed chromatography column, wherein the feed tank, the hold tank(s), the elution buffer tank and the eluate tank are each connected to the packed bed chromatography columns via a system of valves.Type: ApplicationFiled: December 2, 2011Publication date: September 26, 2013Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: Martin Hall, Karol Lacki
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Patent number: 8529757Abstract: A process for separating a product from a multicomponent feedstream to an adsorption apparatus or system. The apparatus or system may comprise a moving-bed or a simulated moving-bed adsorption means. The product comprises at least one organic compound, such as an aryl compound with alkyl substitutes. In embodiments the conduits used to supply the feedstream to the apparatus or system are flushed with media of multiple grades. In embodiments the process achieves improvements in one or more of efficiency of adsorption separation, capacity of adsorption apparatus systems, and purity of product attainable by adsorption process.Type: GrantFiled: May 5, 2010Date of Patent: September 10, 2013Assignee: ExxonMobil Chemical Patents Inc.Inventors: Anthony Go, Dana Lynn Pilliod, John R. Porter
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Patent number: 8496836Abstract: A process for continuous or quasi-continuous purification of a multi-component mixture (F) by means of individual chromatographic columns through which the mixture is fed by means of at least one solvent(s). The multi-component mixture (F) at least comprises light impurities (A), an intermediate product (B) to be purified and heavy impurities (C), and the columns are grouped into at least four sections (?,?,?,?). After or within a switch time (t*) the last column from the first section (?) is moved to the first position of the second section (?), the last column of the second section (?) is moved to the first position of the third section (?), the last column of the third section (?) is moved to the first position of the fourth section (?) and the last column of the fourth section (?) is moved to become the first column of the first section (?).Type: GrantFiled: October 29, 2010Date of Patent: July 30, 2013Assignee: Eidgenossische Technische Hochschule ZurichInventors: Lars Aumann, Massimo Morbidelli