Abstract: A valve closure for dispensing liquid by means of a pressurised gas has an inner sleeve (12) which includes a socket (16) and an annular inner valve seat (18). The inner sleeve carries a ring seal (14) which is urged against an outer valve seat (9) by an outer spring (15). A valve member (21) has an annular sealing face (23) co-operable with the inner valve seat (18) and a spring (24) urges the valve member (21) against the inner valve seat (18). The valve member (21) incorporates a plurality of projections (26) spaced radially from the annular sealing face (23). The valve closure can be used with a dispensing coupler having a tubular probe with a circumferential ring seal and a locking recess to engage the locking fingers of a detachable closing element.

Abstract: The present invention is a method and apparatus for readmitting air into vacuum containers, such as canning jars, by incorporating a flexibly-mounted check valve in the container lid or body, and sandwiching an elastomeric seal member, such as an O Ring, between the check valve and the vacuum container's lid or wall. The check valve is flexibly mounted to the airtight container by a retainer member that permits the check valve to move vertically and horizontally and compresses the elastomeric seal member sufficiently to prevent leakage. Air is readmitted into the vacuum container by applying a force to the check valve that sufficiently decompresses a segment of the elastomeric seal member to cause leakage. The displacement force on the check valve may be applied by hand, without using any tools.

Abstract: The disclosure provides compositions for treating an ocular condition. The composition comprises a physiologically effective amount of an androgen, wherein the composition is suitable for topical administration to an eye. The disclosure further provides methods for treating an ocular condition with the disclosed compositions.

Abstract: Described is a process for producing poliovirus, the process comprising: a) providing a serum-free suspension culture of cells, which are primary human retina (HER) cells that have been immortalized by expression of adenovirus E1 sequences, b) infecting the cells with poliovirus, at a cell density of between 2×106 cells/ml and 150×106 cells/ml, and c) harvesting poliovirus at a time of between 12 and 48 hours after infection.

Abstract: An improved stopper apparatus for use with wine barrel bung holes includes a generally frusto-conical stopper member having a central aperture, a top surface, a bottom surface, and an outer circumferential surface adapted to seal against the inner circumferential surface of the bung hole. The apparatus further includes a sealing insert member having a top portion, a middle portion, and a bottom portion, the top portion having a diameter slightly greater than the stopper member central aperture such that the sealing insert member can be pushed into the central aperture so as to bring the top surface of the sealing insert member with the top surface and the stopper member during barrel aging. The sealing insert member further has a lower surface adapted for sealing engagement against the stopper member top surface during barrel fermentation.

Abstract: An improved stopper apparatus for use with wine barrel bung holes includes a generally frusto-conical stopper member having a central aperture, a top surface, a bottom surface, and an outer circumferential surface adapted to seal against the inner circumferential surface of the bung hole. The apparatus further includes a sealing insert member having a top portion, a middle portion, and a bottom portion, the top portion having a diameter slightly greater than the stopper member central aperture such that the sealing insert member can be pushed into the central aperture so as to bring the top surface of the sealing insert member with the top surface and the stopper member during barrel aging. The sealing insert member further has a lower surface adapted for sealing engagement against the stopper member top surface during barrel fermentation.

Abstract: A stopper apparatus for use with wine barrel bung holes includes a generally frusto-conical stopper member having a central aperture, a top surface, a bottom surface, and an outer circumferential surface adapted to seal against the inner circumferential surface of the bung hole. The apparatus further includes a sealing insert member having a top portion, a middle portion, and a bottom portion, the top portion having a diameter greater than the stopper member central aperture, and which has a lower surface adapted for sealing engagement against the stopper member top surface. The bottom portion includes at least one flexible lateral projection element adapted to contact and apply a force against the stopper member bottom surface, so as to urge the top portion lower surface into sealing engagement with the stopper member top surface.