Abstract: The present application provides a switching power supply and a magnetic resonance imaging system. The switching power supply is used for supplying power to a radio frequency coil control device, wherein the radio frequency coil control device is used for controlling a flow direction of radio frequency power output by a radio frequency amplifier of the magnetic resonance imaging system. Moreover, the switching power supply comprises a first power unit, a second power unit, and an air-cored transformer, the second power unit and the first power unit being electrically coupled through the air-cored transformer, wherein the switching power supply is configured to operate at a preset frequency, and frequency multiplication of the preset frequency is beyond a reception bandwidth of the magnetic resonance imaging system.

Abstract: The present invention provides a method for detecting a monoclonal antibody in a sample, the method comprising: (a) a step of capturing and immobilizing, in pores of a porous body, the monoclonal antibody in the sample; (b) a step of performing selective protease digestion of the monoclonal antibody for 30 min or longer by contacting the porous body having the monoclonal antibody immobilized thereon with nanoparticles having a protease immobilized thereon; and (c) a step of detecting a peptide fragment obtained by the selective protease digestion, using liquid chromatography mass spectrometry (LC-MS), wherein step (b) is carried out under stirring condition for 10 sec to 5 min in the initial reaction stage, and then under static condition. According to the present invention, the detection method of a monoclonal antibody using mass spectrometry is simplified and can be applicable to multisample analysis.

Abstract: A data storage section stores LC/MS analysis data for a large number of culture-medium samples acquired with an LC-MS. Based on those data, a quantitative analyzer calculates concentration values of a large number of compounds in each sample and stores the result in an analysis result storage section. A result display processor retrieves analysis results with the same culture name and different sampling date from the analysis result storage section, creates a table in which concentration values are arranged for each compound and for each sampling date, as well as a graph showing a temporal change in the concentration value of one compound, and displays the table and graph on the same window on a display unit. An operator using an operation unit selects a compound on the displayed table. The result display processor creates a graph for the selected compound and renews the graph on the display.

Abstract: A peak-waveform conversion processor detects a peak in a profile spectrum created based on data obtained at each measurement point in a sample's measurement area, and acquires a rod-like peak by performing centroid conversion processing on a waveform of the peak having a mountain shape. When an operator specifies a target compound to be observed, a mass difference calculation unit calculates a mass difference between a precise m/z of the target compound and an m/z of a rod-like peak at a position close to the precise m/z for each measurement point. A mass difference image creator creates an image showing a distribution of mass differences based on the calculated mass differences. A mass difference related information calculation unit acquires an index value such as an average value of a plurality of mass differences for each mass difference image, and creates a graph showing a frequency distribution of the mass differences.

Abstract: A method of manufacturing a multipole device includes the steps of: (a) forming an intermediate device by assembling a plurality of components including a plurality of precursor multipole electrodes, wherein the plurality of precursor multipole electrodes in the assembled device extend along and are distributed around a central axis; (b) forming a multipole device from the intermediate device by machining the precursor multipole electrodes within the intermediate device to provide a plurality of multipole electrodes having a predetermined spatial relationship; wherein a first component of the multipole device that includes a multipole electrode is attached non-permanently to a second component of the multipole device, the first component including a first alignment formation, and the second component including a second alignment portion configured to engage with the first alignment formation on the first component so as to facilitate alignment of the first component and the second component when the first com

Abstract: The present invention relates to a particle detector comprising at least an optical device configured to emit a luminous radiation; and a substrate extending in a plane and defining a channel intended to receive particles, the channel extending principally in a direction perpendicular to the principal plane; characterised in that the detector comprises a matrix of photo detectors and a reflecting surface; the matrix of photo detectors and the reflecting surface being disposed on mutually parallel planes and situated on either side of said portion of the substrate so that a part of the luminous radiation passes through the channel by being diffracted by a particle, then reflects off the reflecting surface, and then reaches the matrix of photo detectors.

Abstract: There is provided a system and method for angstrom confinement of trapped ions. The method including: receiving water molecules and ionic compounds in a first reservoir, an angstrom confinement assembly is positioned between the first reservoir and a second reservoir, the angstrom confinement assembly defining angstrom conduits; and repeatedly applying an electric field across a first electrode and a second electrode, the first electrode on a same side of the angstrom confinement assembly as the first reservoir and the second electrode on a same side of the angstrom confinement assembly as the second reservoir, the electric field applied such that, when the electric field is applied, positive ions of the ionic compounds are induced to flow through the angstrom conduits, and wherein, when the electric field is not applied, water molecules flow into the angstrom conduits due to capillary forces to confine the positive ions in the angstrom conduits.

Abstract: A method of operating a quadrupole device is disclosed that comprises operating the quadrupole device in a first mode of operation, and operating the quadrupole device in a second mode of operation. Operating the quadrupole device in the first mode of operation comprises applying one or more first voltages to the quadrupole device such that the quadrupole device is operated in an initial stability region and such that at least some ions are stable within the quadrupole device. Operating the quadrupole device in the second mode of operation comprises applying one or more second voltages to the quadrupole device such that the quadrupole device is operated in a different stability region and such that at least some of the ions that were stable within the quadrupole device in the first mode of operation are stable within the quadrupole device in the second mode of operation.

Abstract: A lead-in electrode, of an orthogonal acceleration time-of-flight mass spectrometer, includes: a main body having an ion passing part and a first member including a main-body accommodating part that is a through-hole. One surface of the first member includes an extension part to define a position of one surface of the main body. A second member is attached to the first member. A through-hole is provided at a position of the second member. One surface of the second member includes a first area in contact with a surface opposite to the one surface of the first member and a second area located inside with respect to the first area. The second area is formed lower than a surface, of the first area, in contact with the surface opposite to the one surface. A lead-in electrode elastic member is disposed, in the second area, between the first member and second members.

Abstract: A method of mass spectrometry is disclosed comprising: a) providing temporally separated precursor ions; b) mass analyzing separated precursor ions, and/or product ions derived therefrom, during a plurality of sequential acquisition periods, wherein the value of an operational parameter of the spectrometer is varied during the different acquisition periods; c) storing the spectral data obtained in each acquisition period along with its respective value of the operational parameter; d) interrogating the stored spectral data and determining which of the spectral data for a precursor ion or product ions meets a predetermined criterion, and determining the value of the operational parameter that provides this mass spectral data as a target operational parameter value; and e) mass analyzing again the precursor or product ions whilst the operational parameter is set to the target operational parameter value.

Abstract: A desolvation unit performs desolvation by heating after a sample solution is turned to sample mist by a nebulizer. A sample gas that contains the desolvated sample mist and a carrier gas is introduced through a sample introduction tube to a plasma torch. An addition unit for adding, to the sample introduction tube, a water-containing gas is provided. The addition unit includes a container that contains ultrapure water, a gas tube for introducing the carrier gas into the ultrapure water to cause bubbling, and a gas tube for adding the water-containing gas, to the sample introduction tube. The plasma torch generates an inductively coupled plasma under the condition that supplied power is set to a range of 550 W to 700 W. Generation of interfering molecule ions due to an element having a high ionization potential is inhibited when an element in a sample ionized by the plasma is analyzed.

Abstract: An ion detector for secondary ion mass spectrometer, the detector having an electron emission plate coupled to a first electrical potential and configured to emit electrons upon incidence on ions; a scintillator coupled to a second electrical potential, different from the first electrical potential, the scintillator having a front side facing the electron emission plate and a backside, the scintillator configured to emit photons from the backside upon incidence of electrons on the front side; a lightguide coupled to the backside of the scintillator and confining flow of photons emitted from the backside of the scintillator; and a solid-state photomultiplier coupled to the light guide and having an output configured to output electrical signal corresponding to incidence of photons from the lightguide. A SIMS system includes a plurality of such detectors movable arranged over the focal plane of a mass analyzer.

Abstract: Methods and systems that can use a gas comprising a nitrogen center that is introduced upstream of a plasma sustained in a torch are described. In some configurations, the gas comprising the nitrogen center can be introduced as a gas upstream of the plasma and through a sample introduction device. Mass spectrometers and optical emission systems that can use the gas comprising the nitrogen center are also described.

Abstract: A GC interface assembly for a heated transfer line of a gas chromatography interface probe, the heated transfer line comprising an inner tube and an outer tube, the GC interface assembly comprising: a GC fitting securable to said inner tube, the GC fitting comprising a first section comprising a substantially cylindrical projection for fluid connection to a GC source in use, and a second section having a larger radius than the first section in at least one direction, the second section being provided with at least one flat; and a GC end cap securable to an outer tube, the GC end cap comprising an aperture which slidably receives the second section of the GC fitting in use such that the GC fitting is substantially constrained to liner movement with respect to the GC end cap.

Abstract: A mass spectrometry method includes: preparing calibration data for performing calibration on a basis of first data obtained by detecting a chlorobiphenyl in first mass spectrometry of a reference sample of the chlorobiphenyl; acquiring second data obtained by detecting, in second mass spectrometry of a sample, at least one chlorobiphenyl that has a same chlorine number as and is different in kind from the chlorobiphenyl detected in the first mass spectrometry; and calculating a quantitative value for the chlorobiphenyl contained in the sample on a basis of the calibration data and the second data.

Abstract: A particle acceleration system includes an ion source that generates an ion, an accelerator that accelerates the ion, And a transporting unit that transports the ion from the ion source to the accelerator, in which an attachment angle and an attachment position of the ion source with respect to the transporting unit are able to be adjusted.

Abstract: A CDMS may include an ELIT having a charge detection cylinder (CD), a charge generator for generating a high frequency charge (HFC), a charge sensitive preamplifier (CP) having an input coupled to the CD and an output configured to produce a charge detection signal (CHD) in response to a charge induced on the CD, and a processor configured to (a) control the charge generator to induce an HFC on the CD, (b) control operation of the ELIT to cause a trapped ion to oscillate back and forth through the CD each time inducing a charge thereon, and (c) process CHD to (i) determine a gain factor as a function of the HFC induced on the CD, and (ii) modify a magnitude of the portion of CHD resulting from the charge induced on the CD by the trapped ion passing therethrough as a function of the gain factor.

Abstract: A multi-reflecting time-of-flight mass spectrometer (MR-TOF MS) includes an ion source, an orthogonal accelerator, and an ion mirror assembly. The ion source is capable of generating a beam of ions, and is arranged to accelerate the ions in a first direction along a first axis. The orthogonal accelerator is arranged to accelerate the ions in a second direction along a second axis. The second direction is orthogonal to the first direction. The ion mirror assembly includes a plurality of gridless planar mirrors and a plurality of electrodes. The plurality of electrodes are arranged to provide time-focusing of ions along a third axis substantially independent of ion energy and ion position.

Abstract: A miniature electrode apparatus is disclosed for trapping charged particles, the apparatus including, along a longitudinal direction: a first end cap electrode; a central electrode having an aperture; and a second end cap electrode. The aperture is elongated in the lateral plane and extends through the central electrode along the longitudinal direction and the central electrode surrounds the aperture in a lateral plane perpendicular to the longitudinal direction to define a transverse cavity for trapping charged particles.

Abstract: A microorganism identification method utilizing mass spectrometry is provided. More specifically, a method for identifying a phylotype of Cutibacterium acnes utilizing mass spectrometry is provided. The method includes a) a step for reading out a m/z value of a peak derived from a marker protein on a mass spectrum which is obtained by mass spectrometry of a sample containing microorganisms; and b) a step for judging whether the sample contains Cutibacterium acnes (C. acnes) based on the m/z value.

Abstract: For an automatic adjustment of a detector voltage, a measurement of a standard sample is performed, in which a reflection voltage generator under the control of an autotuning controller applies, to a reflector, voltages which are different from those applied in a normal measurement and do not cause temporal conversion of ions. Ions having the same m/z simultaneously ejected from an ejector are dispersed in the temporal direction and reach a detector. Therefore, a plurality of low peaks corresponding to individual ions are observed on a profile spectrum. A peak-value data acquirer determines a wave-height value of each peak. A wave-height-value list creator creates a list of wave-height values. A detector voltage determiner searches for a detector voltage at which the median of the wave-height values in the wave-height-value list falls within a reference range.

Abstract: In one aspect, a time-of-flight mass spectrometer includes a source comprising a backing plate configured to operably couple to a core sample containing component, and an acceleration region. The time-of-flight mass spectrometer also includes a time-of-flight mass analyzer operably associated with the source region. In some embodiments, the core sample core sample containing component is a coring drill bit. In some embodiments, core containing component is configured to couple to the backing plate of the source region from the opposite side of the acceleration region. In some embodiments, core containing component is configured to couple to the backing plate of the source region on the acceleration region side of the backing plate. In some embodiments, the acceleration region is a single-stage acceleration region. In other embodiments, the acceleration region is a two-stage acceleration region.

Abstract: Thermal management arrangements for analysis systems including a plasma source such as inductively-coupled-plasma are disclosed. An analysis system may include a plasma source configured to a plasma source configured to receive and ionize a sample to create an ionized sample, and an instrument such as a mass spectrometer or optical emission spectrometer configured to receive and analyze the ionized sample. A heat shield may be positioned between the plasma source and the instrument, and the heat shield may be constructed and arranged to direct heated gas and/or plasma from the plasma source away from the instrument. In some instances, the heated gas and/or plasma may be extracted from a chamber containing the plasma source.

Abstract: A laser desorption/ionization method, includes: a first step of preparing a sample support body including a substrate on which a plurality of through holes opening to a first surface and a second surface facing each other are formed, and a conductive layer provided on at least the first surface; a second step of introducing a sample and a solvent having refractoriness in a vacuum into the plurality of through holes; and a third step of ionizing a component of the sample by irradiating the first surface with laser beam while applying a voltage to the conductive layer.

Abstract: A method of analyzing a complex sample includes performing a sequential chromatographic-IMS-MS analysis of a sample to obtain a plurality of experimental mass spectra having isotopic clusters, wherein each spectrum of the plurality of spectra is associated with a chromatographic retention time and an ion-mobility drift time. The method also includes calculating a model isotopic cluster of a precursor or product ion associated with a candidate compound in the sample, in correspondence to the natural isotopic-abundance ratios of elements composing the compound. The method further includes comparing peaks of the model isotopic cluster to corresponding peaks of an isotopic cluster of one of the experimental mass spectra to extract one or more saturated or interfered peaks of the experimental isotopic cluster, wherein at least one of the peaks of the experimental isotopic cluster is un-saturated and un-interfered.

Abstract: A sample introduction system for a spectrometer comprises a desolvation region that receives or generates sample ions from a solvent matrix and removes at least some of the solvent matrix from the sample ions. A separation chamber downstream of the desolvation region has a separation chamber inlet communicating with the desolvation region, for receiving the desolvated sample ions along with non-ionised solvent and solvent ion vapours. The separation chamber has electrodes for generating an electric field within the separation chamber, defining a first flow path for sample ions between the separation chamber inlet and a separation chamber outlet. Unwanted solvent ions and non-ionised solvent vapours are directed away from the separation chamber outlet. The sample introduction system has a reaction chamber with an inlet communicating with the separation chamber outlet, for receiving the sample ions from the separation chamber and for decomposing the received ions into smaller products.

Abstract: In one aspect, a curtain and orifice plate assembly for use in a mass spectrometry system is disclosed, which comprises a curtain plate including a first printed circuit board (PCB) having an aperture configured for receiving ions generated by an ion source of the mass spectrometry system and at least one gas-flow channel, where said first PCB has at least one metal coating disposed on at least a portion thereof. The assembly further includes an orifice plate coupled to the curtain plate, which includes a PCB providing an orifice that is substantially aligned with the aperture of the curtain plate so that the ions entering the assembly via said aperture of the curtain plate can exit the assembly via said orifice of the orifice plate, where the second PCB has at least one metal coating disposed on at least a portion thereof.

Abstract: A method of analysis is disclosed comprising providing a sample on an insulating substrate such as a petri dish 4 and contacting e.g. the rear surface of the insulating substrate with a first electrode 9. The method further comprises contacting the sample with a second electrode 2 and applying an AC or RF voltage to the first and second electrodes 9,2 in order to generate an aerosol from the sample.

Abstract: The invention generally relates to logical operations in mass spectrometry. The system comprising a mass spectrometer comprising one or more ion traps; and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply one or more scan functions to the one or more ion traps, the scan functions being combine together.

Abstract: A detector system for targeted analysis and/or sample collection by distance-of-flight mass spectrometry (tDOF-MS).

Abstract: A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 AMU. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments. An efficient ion source enables relatively low power consumption without sacrificing measurement resolution. Variable geometry mechanical filters allow for variable resolution. An onboard ion pump removes the need for an external pumping source. A magnet and magnetic yoke produce magnetic field regions with different flux densities to run the ion pump and a magnetic sector mass analyzer. An onboard digital controller and power conversion circuit inside the vacuum chamber allows a large degree of flexibility over the operation of the mass spectrometer while eliminating the need for high-voltage electrical feedthroughs. The miniature mass spectrometer senses fractions of a percentage of inlet gas and returns mass spectra data to a computer.

Abstract: The invention generally relates to ion traps and methods of use thereof. In certain embodiments, the invention provides a system that includes a mass spectrometer including an ion trap, and a central processing unit (CPU). The CPU has storage that is coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a constant radio frequency (RF) signal to the ion trap, and apply a first alternating current (AC) signal to the ion trap the frequency of which varies as a function of time.

Abstract: A method of estimating a parameter for fitting a multi-component Taylorgram model to Taylorgram data g(t) is disclosed. The data comprises a multi-component Taylorgram peak or front at t=tr. The method comprises: evaluating a value of an integration or differential of the data; determining the parameter, based on an analytical expression that includes the value of the integral or differential of the data, the parameter corresponding with a physical property of a sample from which the Taylorgram data was obtained.

Abstract: Four rod electrodes (50a to 50d) for separating ions according to a mass-to-charge ratio are held by a rod holder (51). The rod holder (51) is placed on a metal holder sustaining stand (52) provided on a bottom surface of a vacuum housing (1), and is fixed while being pressed by a fixation band (53) fixed to the holder sustaining stand (52) with screws (56). A heat release layer (55) made from heat dissipation silicone or the like is inserted between the fixation band (53) and the rod holder (51) and between the fixation band (53) and the holder sustaining stand (52). Therefore, heat generated in the rod holder (51) due to dielectric loss is not only directly transmitted to the holder sustaining stand (52), but also efficiently transmitted to the holder sustaining stand (52) through the fixation band (53).

Abstract: The present invention relates to a device (1) for measuring a magnetic field (B) and/or an electric field (E) comprising:—a measurement cell (3) enclosing a gas that is sensitive to the Zeeman effect and/or to the Stark effect, a polarised light source (7) the wavelength of which is tuned to an absorption line of the gas that is sensitive to the Zeeman effect and/or to the Stark effect,—at least one polarimetry system (11) configured to measure a first parameter corresponding to the rotation by a polarisation angle caused by the passage of the beam (9) through the measurement cell (3) enclosing a gas that is sensitive to the Zeeman effect and/or to the Stark effect,—a system (13) for measuring absorption, configured to measure a second parameter corresponding to the absorption of the beam (9) by the gas that is sensitive to the Zeeman effect and/or to the Stark effect in the measurement cell (3), and a processing unit (15) configured to combine the measurement of the first parameter corresponding to the rotat

Abstract: An ionizer includes an ionization probe (21) provided with a capillary (211), a metallic slender tube (212), and a nebulizing gas pipe (213). The ionization probe (21) is equipped to perform ESI-based ionization of components in a liquid sample. An electroconductive capillary (22) is disposed at a position forward in a flow direction of a nebulized flow of the liquid sample from the ionization probe (21). A high voltage from a high voltage power supply (23) is applied to the electroconductive capillary (22) to induce corona discharge so that the components in the liquid sample are ionized by the APCI as well. At the time of tuning the ionizer, a standard sample solution is provided through the electroconductive capillary (22), and a high voltage from the high voltage power supply (23) is applied to the electroconductive capillary (22) so that components in the standard sample solution are ionized by the ESI or due to an ion molecular reaction with solvent molecular ions produced in the ionization probe (21).

Abstract: A method of manufacture for a ion mobility filter is disclosed. The method of manufacturing an ion filter for a spectrometry system includes providing a sheet of conductive material and defining a plurality of ion filters on the sheet. The definition of the plurality of ion filters is achieved by forming an electrode layer for each ion filter on the sheet, where each electrode layer comprises at least one ion channel and an isolation channel surrounding the at least one ion channel. A support layer on each electrode layer is also formed. Each support layer comprises an aperture at least partially aligned with the at least one ion channel. The ion filter is then separated. The risk of contaminants entering the at least one ion channel when separating the ion filters is reduced by surrounding the at least one ion channel with the isolation channel.

Abstract: A method for cleaning an electrospray emitter of a mass spectrometer, comprises: (a) changing a mode of operation of the electrospray emitter from a stable jet mode of operation to a dripping mode or a pulsating mode of operation by lowering a magnitude of a voltage applied between an counter electrode and the electrospray emitter; (b) causing a cleaning solvent to flow through the electrospray emitter at least until a droplet of the cleaning solvent forms on an exterior surface of the electrospray emitter while operating the electrospray emitter in the dripping mode of operation; and (c) causing the droplet to dislodge from the electrospray emitter exterior.

Abstract: A method of mass spectrometry is disclosed comprising: performing a plurality of cycles of operation during a single experimental run, wherein each cycle comprises: mass selectively transmitting precursor ions of a single mass, or range of masses, through or out of a mass separator or mass filter at any given time, wherein the mass separator or mass filter is operated such that the single mass or range of masses transmitted therefrom is varied with time; and mass analysing ions.

Abstract: An amplification system includes a first amplification module, a second amplification module, a third amplification module I, a fourth amplification module I, a first load, a third amplification module II, a fourth amplification module II and a second load. An output terminal of the first amplification module is connected to an input terminal of the second amplification module; output terminals of the second amplification module are connected to an input terminal of the third amplification module I and an input terminal of the third amplification module II. An output terminal of the third amplification module I is connected to an input terminal of the first load through the fourth amplification module I. An output terminal of the third amplification module II is connected to an input terminal of the second load through the fourth amplification module II.

Abstract: Certain configurations of systems and methods that can detect inorganic ions and organic ions in a sample are described. In some configurations, the system may comprise one, two, three or more mass spectrometer cores. In some instances, the mass spectrometer cores can utilize common components such as gas controllers, processors, power supplies and vacuum pumps. In certain configurations, the systems can be designed to detect both inorganic and organic analytes comprising a mass from about three atomic mass units, four atomic mass units or five atomic mass units up to a mass of about two thousand atomic mass units.

Abstract: The present invention is directed to a method and device to desorb an analyte using heat to allow desorption of the analyte molecules, where the desorbed analyte molecules are ionized with ambient temperature ionizing species. In various embodiments of the invention a current is passed through a mesh upon which the analyte molecules are present. The current heats the mesh and results in desorption of the analyte molecules which then interact with gas phase metastable neutral molecules or atoms to form analyte ions characteristic of the analyte molecules.

Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing ions towards an ion storage region; selecting a target maximum charge desired to be stored within the ion storage region at any given time; and reducing the ion current passing to the ion storage region such that the ions entering the ion storage region do not cause the total charge within the storage region to rise above said target maximum charge. The step of reducing the ion current passing to the ion storage region comprises: temporally separating the ions according to their ion mobility in an ion mobility separator; and mass filtering the ions according to mass to charge ratio with a mass filter. Said steps of separating and mass filtering the ions result in substantially only target ions having selected combinations of ion mobility and mass to charge ratio being transmitted towards the ion storage region.

Abstract: Disclosed herein are embodiments of a system for selectively ionizing samples that may comprise a plurality of different analytes that are not normally detectable using the same ionization technique. The disclosed system comprises a unique split flow tube that can be coupled with a plurality of ionization sources to facilitate using different ionization techniques for the same sample. Also disclosed herein are embodiments of a method for determining the presence of analytes in a sample, wherein the number and type of detectable analytes that can be identified is increased and sensitivity and selectivity are not sacrificed.

Abstract: A method is disclosed comprising obtaining physical or other non-mass spectrometric data from one or more regions of a target using a probe. The physical or other non-mass spectrometric data may be used to determine one or more regions of interest of the target. An ambient ionisation ion source may then used to generate an aerosol, smoke or vapour from one or more regions of the target.

Abstract: Provided is a tactile feedback device including a tactile transmission element having an enclosed space inside, the tactile transmission element including a compression part which is compressed toward the enclosed space by an electrostatic force generated by the application of voltage, and a tactile part which transmits tactile sensation to a user by expansion with movement of air by the compression.

Abstract: Systems and methods are disclosed for determining if the dynamic range of quantitation in mass spectrometry can be extended. A DIA method is performed on a sample for a compound of interest at each acquisition time of a plurality of acquisition times. A plurality of product ion spectra are produced for each window of two or more precursor ion mass selection windows. A known product ion of the compound of interest is selected. Two or more XICs are calculated from two or more different precursor ion windows for the known product ion. A ratio of one XIC of the two or more XICs to at least one other XIC of the two or more XICs is calculated. If the ratio is above a threshold, the XIC is used in the quantitation. If not, two or more XICs can be combined into a single XIC that is used for the quantitation.

Abstract: A device for generating negative ions comprises: a) an ionizer (14) including a heatable ionizer surface; b) a heater (60) for heating said ionizer whereby positive ions (30) are generated at said ionizer surface (14e); c) a target (34) including a material for generating negative ions when said positive ions impigne on said material; wherein d) said ionizer is arranged opposite the target; e) said target is electrically negatively biased in respect to said ionizer; f) said ionizer comprises an aperture (22) through which said generated negative ions are extracted from said target to generate a beam (50) of negative ions; and wherein g) said ionizer surface (14e) is planar.

Abstract: An ion guiding device includes ring electrodes with a same size disposed in parallel; wherein a connection line of centers of the ring electrodes is defined as an axis, a normal of a plane where any of the ring electrodes is located and a tangent line of the axis at a center of the ring electrode form an included angle being a range of (0, 90) degrees; a radio-frequency voltage source, for applying an out-phase radio-frequency voltage on a neighboring ring electrode along the axis, so that ions are confined inside the ring electrode during a transmission process; and a direct-current voltage source, applying a direct-current voltage with an amplitude changing along the axis on the ring electrode, so that the ions are transmitted along the axis and focused to a position closer to an inner surface of the ring electrode along a direction of the normal.

Abstract: A method of injecting ions into an ion storage device, comprising: providing an RF trapping field in the ion storage device that defines a trapping volume in the ion storage device by applying one or more RF voltages to one or more trapping electrodes; providing a gas in the trapping volume; injecting ions into the trapping volume through an aperture in an end electrode located at a first end of the ion storage device, the end electrode having a DC voltage applied thereto; reflecting the injected ions at a second end of the ion storage device, opposite to the first end, thereby returning the ions to the first end; and ramping the DC voltage applied to the end electrode during the period between injecting the ions through the aperture and the return of the ions to the first end, such that by the time the ions return to the first end for a first time a potential barrier is established by the ramped DC voltage that prevents returning ions from striking the end electrode.