Aspartylphenylalanone Esters And Cyclohexylalanine Esters Patents (Class 260/998.21)
  • Selective MMP inhibitors having reduced side-effects
    Patent number: 6818622
    Abstract: The subject invention pertains to matrix metalloproteinase (MMP) inhibitors that exhibit an IC50 of below 10−4M against MMP and have substantially no activity against non-MMP metalloproteinase-related events. The MMP inhibitors of the invention have reduced side-effects, especially with respect to joint pain.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: November 16, 2004
    Assignee: Darwin Discovery Ltd.
    Inventors: John Bird, John Gary Montana, Ruth Elizabeth Wills, Andrew Douglas Baxter, David Alan Owen
  • Peptidyl compounds
    Patent number: 6180611
    Abstract: Compounds of general formula (I): have utility as inhibitors of matrix metalloproteinases and TNF.
    Type: Grant
    Filed: May 20, 1999
    Date of Patent: January 30, 2001
    Assignee: Darwin Discovery, Ltd.
    Inventors: John Montana, Andrew Douglas Baxter, David Alan Owen, Robert John Watson, Neil Phillipson