Abstract: Single dose formulations containing a combination of a lipid regulating agent selected from gemfibrozil, clofibrate, bezafibrate, or fenofibrate and an ACAT inhibiting agent are effective pharmacological formulations for regulating blood serum lipid and cholesterol levels.

Abstract: Substantially pure neocarzinostatin anticancer agents have the formula (A):(SMA)--(NCS)--(SMA) (A)wherein (NCS) is a divalent neocarzinostatin residue and (SMA) comprises the monovalent residue of a partially half-esterified styrene-maleic acid copolymer having a weight-average molecular weight of from 800 to 2,500, said (NCS) residue being bonded to said (SMA) residues via amide linkages formed between primary amino groups of the neocarzinostatin molecule and carbonyl groups of the partially half-esterified styrene-maleic acid copolymer.

Abstract: Novel neocarzinostatin anticancer agents have the formula:(SMA)--(NCS)wherein (NCS) is a neocarzinostatin residue, n is an integer ranging from 1 to 35, and (SMA) comprises the residue of a half-esterified styrene-maleic acid copolymer having an average molecular weight of from 1,000 to 10,000, said half-esterified styrene-maleic acid copolymer comprising (i) styrene residues, (ii) maleic acid residues covalently bonded to (NCS), (iii) free maleic acid residues, and (iv) half-esterified maleic acid residues, and further wherein the total amount of said residues (ii) and (iii) ranges from an average of 0.1 per molecule to 60 mole % of said (SMA).

Abstract: The calcium salts of the solid cyclic copolymers of divinyl ether and maleic anhydride, soluble in water, have been found to be as effective in treating tumors and viruses as the prior art alkali metal salts (e.g., the sodium salt) but much less toxic. These copolymers are characterized by containing divinyl ether and maleic anhydride in a mole ratio of about 1:2, having a molecular weight of from about 2000 to about 100,000 and from about 5% to about 70% of its carboxylic acid groups converted to calcium salts.

Abstract: Iodophor powders are prepared by suspending a particulate iodophor-forming polymer in an iodine solution in which the polymer is insoluble, and adding to the suspension a solution of an iodide in a solvent system miscible with the solvent of the iodine solution, to cause the formation of an iodophor. The iodophor can be separated from the solvent by filtration.

Abstract: A stable, compatible thixotropic gel of the type gelled from a mixture including a solvent, a cosolvent and a gelling agent. The gelling agent comprises a copolymer of ethylene and at least one comonomer selected from the group consisting of acrylic acid, methacrylic acid, ethacrylic acid, esterified acrylic acid, vinyl acetate, vinyl formate, vinyl propionate and mixtures thereof. The copolymer has a number average molecular weight between about 500 and about 10,000.

Abstract: A novel microporous resin which is useful in the treatment of hyperchloesterolemia. This resin is comprised of a cross-linked polystyrene matrix and is characterized by active moieties selected from among methylamino, methylammonium or a combination of methylamino and methylammonium groups. The porosity of this resin is capable of absorbing and retaining bile salts having an average diameter of 150-200 Angstrom units.

Abstract: A generic polymeric agent for releasing 5-aminosalicylic acid or its salts is disclosed which comprises a nonabsorbable pharmacologically acceptable organic polymer backbone containing aromatic rings to which are covalently bonded via azo bonds a plurality of salicylic acid or salicylate salt groups. The azo bonds attach to the salicylates' 5-position carbon. The polymers undergo bacterial cleavage in the mammalian lower bowel to release 5-aminosalicylic acid and/or its salts.

Abstract: Neocarzinostatin derivatives having the formula; ##STR1## wherein N represents a neocarzinostatin residue, and R.sub.1 +R.sub.2 represents a residue of polystyrene-maleic acid copolymer having a molecular weight of 2,500 to 80,000. These neocarzinostatin derivatives are prepared by reacting neocarzinostatin with a polystyrene-maleic acid copolymer containing at least one maleic anhydride residue per molecule.The neocarzinostatin derivatives exhibit anticarcinogenic activity.

Abstract: An antibacterial and antifungal material comprising a polymer containing carboxyl groups in an amount of at least about 0.008 milliequivalent per gram of the polymer and antibacterial and antifungal metallic ions ionically bonded to the carboxyl groups in an amount of at least about 0.0009 millimole per gram of the polymer.

Abstract: Polymeric form of a biologically active compound containing at least one -NH.sub.2 group in its molecule, adapted for the protracted release of said biologically active compound by enzymatic cleavage of the polymer in vivo in the organism. The active compound is bonded by its -NH.sub.2 group to the carboxylic group of an L-amino acid as for instance, .beta.-phenylalanine, tyrosine, tryptophane, lysine, arginine, glycine, alanine, leucine, citruline or ornithine, which latter is in twin bonded by its amino group to the terminal carboxylic group of the side chain of a substituted amide or ester of acrylic or methacrylic acid, said side chain constituting a linear moiety containing at least 3 carbon atoms.

Abstract: A dry, solid, water-swellable, water-insoluble absorbent composition of matter comprises an ionic complex of a water-soluble anionic poly-electrolyte and a polyvalent metal cation. The composition is characterized by an ability to uncomplex at an elevated pH and recomplex at a lower pH.