With Treatment Subsequent To Solid Wall Formation (e.g., Coating, Hardening, Etc.) Patents (Class 264/4.3)
-
Patent number: 9468591Abstract: A sunscreen composition comprised of one or more sunscreen active agents encapsulated in a cellulose derived capsule wherein the composition can contain one or more additional agents. A sunscreen composition can be mixed with a bodywash, shampoo, conditioner, lotion, gel, soap, cream, hand sanitizer, spray or mousse and can be used by an individual during their normal hygiene processes, such as during a shower or bath or while applying a body product to their skin or hair.Type: GrantFiled: May 3, 2014Date of Patent: October 18, 2016Assignee: CoLabs International CorporationInventor: Laura E. Cohen
-
Patent number: 9456967Abstract: A sunscreen composition comprised of one or more sunscreen active agents encapsulated in a cellulose derived capsule wherein the composition can contain one or more additional agents. A sunscreen composition can be mixed with a bodywash, shampoo, conditioner, lotion, gel, soap, cream, hand sanitizer, spray or mousse and can be used by an individual during their normal hygiene processes, such as during a shower or bath or while applying a body product to their skin or hair.Type: GrantFiled: May 3, 2014Date of Patent: October 4, 2016Assignee: CoLabs International CorporationInventor: Laura E. Cohen
-
Patent number: 9456968Abstract: A sunscreen composition comprised of one or more sunscreen active agents encapsulated in a cellulose derived capsule wherein the composition can contain one or more additional agents. A sunscreen composition can be mixed with a bodywash, shampoo, conditioner, lotion, gel, soap, cream, hand sanitizer, spray or mousse and can be used by an individual during their normal hygiene processes, such as during a shower or bath or while applying a body product to their skin or hair.Type: GrantFiled: May 3, 2014Date of Patent: October 4, 2016Assignee: CoLabs International CorporationInventor: Laura E. Cohen
-
Patent number: 9441070Abstract: Compositions containing a divinylarene dioxide and a hydroxy-substituted dioxide compound and having relatively low viscosity and reduced volatility are used as underfills in the manufacture of electronic assemblies.Type: GrantFiled: September 11, 2013Date of Patent: September 13, 2016Assignee: Rohm and Haas Electronic Materials LLCInventor: Paul L. Morganelli
-
Patent number: 9333191Abstract: Provided herein are mast cell stabilizers used to prevent, treat, or mitigate severity of laminitis. Mast cell stabilizers can be combined with antihistamines and other medicaments to prevent, treat, or mitigate severity of laminitis.Type: GrantFiled: August 19, 2015Date of Patent: May 10, 2016Assignee: WILLOWCROFT PHARM INC.Inventor: Charles F. Owen
-
Patent number: 9220929Abstract: The invention relates to the use of a haemoglobin for the preparation of dressings and to the resulting dressings.Type: GrantFiled: June 10, 2008Date of Patent: December 29, 2015Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS, Hemarina, UNIVERSITE PIERRE ET MARIE CUREInventors: Franck Zal, Morgane Rousselot
-
Patent number: 9187577Abstract: A filled nanoparticle includes a nanosized polymer shell encapsulating a reactive chemical. In another aspect, a filled nanoparticle includes a nanosized polymer shell encapsulating a core which includes a reactive functional group attached to a polymer. A miniemulsion polymerization process of producing filled nanoparticles includes: providing a mixture comprising monomer, initiator or catalyst to aid polymerization, reactive chemical, surfactant and water; shearing the mixture to form a miniemulsion of nanosized particles dispersed in water, the nanosized particles comprising the monomer combined with the reactive chemical; and then heating the miniemulsion to polymerize the monomer and produce filled nanoparticles comprising a nanosized polymer shell encapsulating the reactive chemical.Type: GrantFiled: May 12, 2009Date of Patent: November 17, 2015Assignee: Battelle Memorial InstituteInventors: Ramanathan S. Lalgudi, Jeff J. Boyce, Barry L. McGraw
-
Patent number: 9155764Abstract: Red blood cell membrane derived microparticles (RMP) are safe, economical, effective hemostatic agents in the treatment of a wide range of bleeding conditions and can be considered as universal hemostatic agents. RMP are produced from red blood cells using a high-pressure extrusion membrane shear process and can be lyophilized after production and retain activity even when stored at room temperature. RMP can be administered to original donors (autologous treatment), thus avoiding transfusion complications, or can be administered to blood type compatible recipients. RMP produced from type O, Rh negative red cells can be given to any person regardless of blood type. RMP can be administered to reduce excessive bleeding resulting from trauma, surgeries, invasive procedures and various bleeding disorders such as platelet disorders, either congenital or acquired, and coagulation disorders, either congenital or acquired.Type: GrantFiled: January 24, 2012Date of Patent: October 13, 2015Assignee: University of MiamiInventors: Yeon S. Ahn, Wenche Jy, Lawrence L. Horstman
-
Publication number: 20150137399Abstract: An extrusion process comprises extruding a material that is flowable when heated and passing the extrudate thus formed through a nozzle 10 to shape the extrudate into a plurality of substantially uniformly shaped elements such as minispheres or minicapsules.Type: ApplicationFiled: December 30, 2014Publication date: May 21, 2015Applicant: SIGMOID PHARMA LTD.Inventor: Ivan Coulter
-
Publication number: 20150130096Abstract: The polarization of nuclear spins of a material may be enhanced by encapsulating the material within a reverse micelle.Type: ApplicationFiled: May 9, 2013Publication date: May 14, 2015Inventor: Andrew Joshua Wand
-
Patent number: 9028705Abstract: A capsule having a solid core, a primary shell of liquid encapsulating the solid core and a secondary shell of particles encapsulating the primary shell. The primary and secondary shells are generally repulsive to each other. Also provided is a process for the manufacture of capsules and a process for the manufacture of a magnetic body.Type: GrantFiled: May 31, 2012Date of Patent: May 12, 2015Assignee: Magnequench LimitedInventors: Zhao Wei, Han Zhisan, David Miller
-
Patent number: 9005494Abstract: Prior art processes for producing protein-based capsules (for example, capsules for use in electrophoretic media) tend to be wasteful because they produce many capsules outside the desired size range, which is typically about 20 to 50 ?m. Capsule size distribution and yields can be improved by either (a) emulsifying a water-immiscible phase in a preformed coacervate of the protein; or (b) using a limited coalescence process with colloidal alumina as the surface-active particulate material.Type: GrantFiled: August 10, 2009Date of Patent: April 14, 2015Assignee: E Ink CorporationInventors: Peter J. Valianatos, Rajesh Chebiyam, Jeremy J. Manning, Michael L. Steiner, Thomas H. Whitesides, Michael D. Walls
-
Patent number: 8980312Abstract: The present invention is directed to a dried seamless capsule comprising an alginate shell membrane encapsulating fill material, wherein: (i) the alginate shell membrane comprises a polyvalent metal ion alginate having: (a) an average M content of from 50%-62% by weight based on the weight of the M and G content, and (b) a viscosity of 35 to 80 cps; (ii) the alginate shell membrane encapsulates an oil present in an amount of at least 50% by weight of the fill material; (iii) the dried seamless capsule has a disintegration time of less than 12 minutes in an intestinal buffer after pretreatment for 20 minutes; and (iv) the dried seamless capsule has a dry break force strength of at least 7 kg.Type: GrantFiled: September 2, 2010Date of Patent: March 17, 2015Assignee: FMC CorporationInventors: Olav Gaserod, Christian Klein Larsen, Peder Oscar Andersen
-
Publication number: 20150072000Abstract: Method for producing enteric microcapsules without coating, containing diclofenac or one of the salts thereof with satisfactory anti-inflammatory activity and low gastric aggressiveness; and a pharmaceutical composition containing them. The method comprises a) preparing a mixture in water-ethanol with an alginate salt, adding diclofenac or one of the salts thereof previously diluted with a surfactant and sodium bicarbonate; b) adding the previous solution to a solution with a calcium salt; c) resuspending the microcapsules obtained and isolated in an aqueous solution of the alginate salt; and d) isolating, drying and sieving through 1000 and 250 micron meshes the microcapsules obtained; and selecting the fraction comprised between both meshes. The pharmaceutical composition can be an oral composition, tablets, chewable tablets, or a powder for suspension in water.Type: ApplicationFiled: March 20, 2012Publication date: March 12, 2015Applicants: Eastbrand Holdings GMBH, Laboratorios Bago S.A.Inventor: Mario Atilio Los
-
Publication number: 20150030671Abstract: A method of preparing and composition of bioavailable hydrophobic, poorly water soluble drugs. It uses for example, lecithin, sterol, a calcium salt, and solvent; mixing to form liposomes and then the solvent driven off; the ratios used and physical form differ from others, and maximize performance.Type: ApplicationFiled: August 6, 2014Publication date: January 29, 2015Inventor: Curtis A. Spilburg
-
Publication number: 20140360981Abstract: A medical contrast agent made of microbubbles containing Au nanoclusters is provided. The shell of the microbubbles contains fluorescent Au nanocluster-albumin complex, and the core contains air or fluorocarbons. The method for preparing the microbubbles is also disclosed.Type: ApplicationFiled: August 26, 2014Publication date: December 11, 2014Inventors: Cheng-An J. Lin, Walter Hong-Shong CHANG, Chih-Hsien LEE, Wen-Kai CHUANG
-
Patent number: 8865032Abstract: The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft gel capsules.Type: GrantFiled: August 13, 2013Date of Patent: October 21, 2014Assignee: Soft Gel Technologies, Inc.Inventor: Michael Fantuzzi
-
Patent number: 8859641Abstract: Particle in the shape of an encapsulated droplet comprising a core material and a shell material surrounding the core material, the shell material containing maleimide groups, preferably a copolymer of maleimide groups. The shell material contains a copolymer of styrene and maleic anhydride derivatives, of which more than 75 mole %, preferably more than 90 mole % is maleimide, and the average particle size is smaller than 300 nm. The particles are obtained by a process comprising by heating between 80° C. and 195° C., more preferably between 120° C. and 190° C. an ammonium salt of a maleic anhydride containing polymer in the presence of the core material.Type: GrantFiled: July 23, 2007Date of Patent: October 14, 2014Assignee: Topchim N.V.Inventor: Henk Jan Frans Van Den Abbeele
-
Patent number: 8852646Abstract: Implantable materials may be used in an iatrogenic site. Applications include radioopaque materials for fiducial marking. Applications include a method of treating a patient with a pharmaceutically acceptable implant system comprising implanting a collection of pharmaceutically acceptable, covalently-crosslinked hydrogel particles, wherein the collection comprises a plurality of sets of the particles, with the sets having different rates of biodegradation.Type: GrantFiled: January 25, 2013Date of Patent: October 7, 2014Assignee: Incept, LLCInventors: Patrick Campbell, Amarpreet S. Sawhney
-
Publication number: 20140287008Abstract: A hybrid polyurea encapsulate formulation obtained by mixing a starch/fragrance emulsion with a polyurea capsule suspension is provided as is a method of using the formulation in a personal care product, a beauty care product, a fabric care product, a home care product, a personal hygiene product, an oral care product and a method for releasing an encapsulated fragrance by moisture, shear, or a combination thereof.Type: ApplicationFiled: June 9, 2014Publication date: September 25, 2014Inventors: Yabin Lei, Michael V. Imperiale, Lewis M. Popplewell, Franklin Pringgosusanto, Ralph Gencarelli
-
Publication number: 20140287433Abstract: This invention relates to a method of determining presence, amount and/or activity of a clostridial neurotoxin in a sample, the method comprising or consisting of the following steps: (a) bringing said sample into contact with a liposome, said liposome comprising (aa) at least one receptor on its outer surface, said receptor being capable of binding said neurotoxin and comprising or consisting of (i) a glycolipid and (ii) a peptide or protein; and (ab) a substrate in its interior, said substrate (i) being cleavable by the peptidase comprised in said neurotoxin and (ii) generating a detectable signal upon cleavage, said detectable signal preferably being generated by (1) the donor of a FRET pair, said donor exhibiting increased fluorescence upon cleavage by said peptidase, (2) a luminescent compound formed upon said cleavage, or (3) an enzyme formed upon said cleavage; and (b) determining whether an increase in signal occurs as compared to the absence of said sample, wherein such increase is indicative of theType: ApplicationFiled: July 18, 2012Publication date: September 25, 2014Applicants: ETH ZÜRICH, VERTEIDIGUNG, BEVÖLKERUNGSSCHUTZ UND SPORT, TOXOGEN GMBH, MIPROLAB GMBHInventors: Oliver Weingart, Marc Avondet, Martin Loessner, Andreas Rummel, Frank Gessler
-
Publication number: 20140271824Abstract: The present invention relates to a liposomal formulation for oral delivery of a bioactive agent that considers pH stability and oxidative stability of a bioactive ingredient. These lipid formulations are superior to conventional liposomes due to their stability, thereby circumventing the need for intra-venous delivery of bioactive agents. In one embodiment, the methods and compositions of the present invention relate to the oral delivery of insulin or a prodrug thereof.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: The Penn State Research FoundationInventors: Mark Kester, Karam El-Bayoumy, Christine Skibinski, Arunangshu Das
-
Publication number: 20140212480Abstract: Described herein are pharmaceutical compositions according to aspects of the present invention which include one or more hydrophilic antineoplastic chemotherapeutics, such as vinca alkyloid antineoplastic chemotherapeutics, encapsulated in ceramide anionic liposomes. Methods of treatment of a subject having cancer using the pharmaceutical compositions are described, along with methods of making ceramide anionic liposomes which encapsulate one or more hydrophilic antineoplastic chemotherapeutics in the aqueous interior of the ceramide anionic liposomes.Type: ApplicationFiled: April 3, 2014Publication date: July 31, 2014Applicant: The Penn State Research FoundationInventors: Mark Kester, Sriram S. Shanmugavelandy, Todd Fox
-
Publication number: 20140200141Abstract: A capsule suspension formulation comprising microencapsulated pendimethalin comprising a herbicidally effective amount of pendimethalin being encapsulated within a polymeric wall, said polymeric wall being in-situ formed by an interfacial polymerization reaction occurring between a first phase dispersed in a second phase, at least one of said first and second phases being characterized in comprising a pre-defined amount of at least one alkali or alkaline earth metal salt of an organic acid; and a herbicidally effective amount of a second herbicide.Type: ApplicationFiled: September 29, 2011Publication date: July 17, 2014Applicant: UPL LIMITEDInventors: Jaidev Rajnikant Shroff, Vikram Rajnikant Shroff, Prakash Mahadev Jadhav, Christian Becker
-
Publication number: 20140191430Abstract: The present invention relates to a method for producing microcapsules having a calibrated diameter and at least one parameter characteristic of the mechanical properties of an equally calibrated microcapsule, characterized in that the method includes the steps of: producing microcapsules by means of injection into a microsystem (10) of three fluids (f1, f2, f3); deforming the microcapsules by means generating a flow within a capillary tube (20); observing and acquiring the outline of at least one deformed microcapsule observed by an optical acquisition means (30); comparing the acquired outline with outlines from a collection of reference microcapsule outlines; determining the diameter and said at least one parameter characteristic of the mechanical properties of the observed microcapsule; and modifying the flow rates (Q1, Q2, and/or Q3) of the fluids (f1, f2, f3). The present invention also relates to a system for producing calibrated microcapsules.Type: ApplicationFiled: April 23, 2012Publication date: July 10, 2014Inventors: Eric Leclerc, Anne-Virginie Salsac, Dominique Barthes-Biesel, Thi Xuan Chu
-
Patent number: 8765030Abstract: Hydrophobic liquids are microencapsulated by an enteric matrix in an environment substantially free of organic solvents, the process including forming an emulsion of the enteric material and hydrophobic liquid in water, the emulsion titrated with an acid to form a particulate precipitate of the microencapsulated hydrophobic liquid in an enteric matrix.Type: GrantFiled: May 18, 2012Date of Patent: July 1, 2014Assignee: Intercontinental Great Brands LLCInventors: Ahmad Akashe, Anilkumar Ganapati Gaonkar, Les Lawrence, Amado R. Lopez, Ronald L. Meibach, Dana Sebesta, Yan Wang, James D. White
-
Patent number: 8747892Abstract: The present invention describes processes for the preparation of a lipid blend and a uniform filterable phospholipid suspension containing the lipid blend, such suspension being useful as an ultrasound contrast agent.Type: GrantFiled: July 25, 2013Date of Patent: June 10, 2014Assignee: Lantheus Medical Imaging, Inc.Inventors: Poh K. Hui, John E. Bishop, Eleodoro S. Madrigal, Jr.
-
Publication number: 20140151912Abstract: Methods and apparatuses for encapsulating inorganic micro- or nanostructures within polymeric microgels are described. In various embodiments, viruses are encapsulated with microgels during microgel formation. The viruses can provide a template for in situ synthesis of the inorganic structures within the microgel. The inorganic structures can be distributed substantially homogeneously throughout the microgel, or can be distributed non-uniformly within the microgel. The inventive microgel compositions can be used for a variety of applications including electronic devices, biotechnological devices, fuel cells, display devices and optical devices.Type: ApplicationFiled: February 7, 2014Publication date: June 5, 2014Applicants: President and Fellows of Harvard college, Massachusetts Institute of TechnologyInventors: Yoon Sung Nam, Angela Belcher, Daeyeon Lee, Jin-Woong Kim, David Weitz
-
Patent number: 8715545Abstract: The present systems and methods utilize a polyamic acid solution as a precursor to form a polyimide bead having desired properties. The polyamic acid solution may be formed into a polyamic acid droplet. The polyamic acid droplet is then processed to form a polyamic acid bead, such as by extraction of solvent to concentrate the polyamic acid or by partial chemical imidization of the polyamic acid. The polyamic acid bead is then better able to retain its shape during subsequent processing steps, such as drying and pressurizing, before final thermal imidization.Type: GrantFiled: September 3, 2010Date of Patent: May 6, 2014Assignee: ExxonMobil Upstream Research CompanyInventors: Dennis G. Peiffer, Barbara Carstensen, Richard S. Polizzotti, Arnold Lustiger, David C. Dalrymple, Walter T. Matuszek
-
Publication number: 20140103553Abstract: An embodiment of the invention provides a method for forming microcapsules for electrophoresis display by forming microcapsules through a complex coacervation reaction between a sulfonated styrene maleic anhydride copolymer and gelatin, wherein a mass ratio of the sulfonated styrene maleic anhydride copolymer to the gelatin is 1:10˜10:1. The method of the embodiment of the invention not only can obtain microcapsules with good sealability and stability, but also can obtain microcapsules having evenly distributed particle sizes and low cost.Type: ApplicationFiled: September 24, 2012Publication date: April 17, 2014Applicant: BOE TECHNOLOGY GROUP CO., LTD.Inventors: Wenwen Sun, Chuanxiang Xu
-
Patent number: 8685441Abstract: The present invention describes processes for the preparation of a lipid blend and a uniform filterable phospholipid suspension containing the lipid blend, such suspension being useful as an ultrasound contrast agent.Type: GrantFiled: July 23, 2013Date of Patent: April 1, 2014Assignee: Lantheus Medical Imaging, Inc.Inventors: Poh K. Hui, John E. Bishop, Eleodoro S. Madrigal, Jr.
-
Patent number: 8658205Abstract: The present invention describes processes for the preparation of a lipid blend and a uniform filterable phospholipid suspension containing the lipid blend, such suspension being useful as an ultrasound contrast agent.Type: GrantFiled: August 1, 2011Date of Patent: February 25, 2014Assignee: Lantheus Medical Imaging, Inc.Inventors: Poh K. Hui, John E. Bishop, Eleodoro S. Madrigal, Jr.
-
Publication number: 20140044761Abstract: A hybrid encapsulate formulation obtained by mixing a starch/fragrance emulsion with a core-shell capsule suspension is provided as is a method of using the formulation in a personal care product, a beauty care product, a fabric care product, a home care product, a personal hygiene product, an oral care product and a method for releasing an encapsulated fragrance by moisture, shear, or a combination thereof.Type: ApplicationFiled: October 18, 2013Publication date: February 13, 2014Applicant: International Flavors & Fragrances Inc.Inventors: Yabin Lei, Michael V. Imperiale, Lewis M. Popplewell, Franklin Pringgosusanto, Ralph Gencarelli
-
Publication number: 20140039072Abstract: Provided is a method for producing vesicles which comprise a lipid as a main component and which encapsulate a functional substance therein. The method includes the steps of (a) putting the functional substance, lipid and water in a cylindrical container; and (b) producing the vesicles encapsulating the functional substance in lipid vesicles which comprise the lipid as a major component and which encapsulate the functional substance therein, by kneading the contents of the container with simultaneous rotational movement of the container around its center axis together with revolutionary movement of the container about a predetermined axis of revolution.Type: ApplicationFiled: April 4, 2012Publication date: February 6, 2014Applicant: WASEDA UNIVERSITYInventor: Hiromi Sakai
-
Publication number: 20140010885Abstract: A self-assembling nanoparticle drug delivery system for the delivery of various bioactive agents including peptides, proteins, nucleic acids or synthetic chemical drugs is provided. The self-assembling nanoparticle drug delivery system described herein includes viral capsid proteins, such as Hepatitis B Virus core protein, encapsulating the bioactive agent, a lipid layer or lipid/cholesterol layer coat and targeting or facilitating molecules anchored in the lipid layer. A method for construction of the self-assembling nanoparticle drug delivery system is also provided.Type: ApplicationFiled: January 18, 2012Publication date: January 9, 2014Inventors: Miguel de los Rios, Kenneth J. Oh, Timothy L. Bullock, Patrick T. Johnson, Jacek Ostrowski
-
Publication number: 20130336891Abstract: Formulation of acoustically activatable particles having low vaporization energy and methods for using same are disclosed. According to one aspect, a method of producing particles of materials includes, with a first substance that includes at least one component that is a gas at room temperature and atmospheric pressure, performing one of: causing the first substance to condense to a liquid phase, and extruding or emulsifying the first substance into or in the presence of a second substance to create a droplet or emulsion in which the first substance is encapsulated by the second substance; or extruding or emulsifying the first substance into or in the presence of a second substance to create a bubble in which the first substance is encapsulated by the second substance and wherein at least some of the first substance is in a gaseous phase, and causing the first substance to condense to a liquid phase, which causes the bubble to transform into a droplet or emulsion.Type: ApplicationFiled: October 11, 2011Publication date: December 19, 2013Applicant: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILLInventors: Paul A. Dayton, Paul S. Sheeran, Terry O. Matsunaga, Mark A. Borden
-
Publication number: 20130307170Abstract: The invention relates to blood substitute compositions, and methods of use thereof. Described herein are compositions in which hemoglobin is maintained substantially in the reduced form of hemoglobin as opposed to the oxidized methemoglobin form through inclusion of an oxido-reductase enzyme and reducing agent within a vesicle with the hemoglobin. The vesicles additionally can comprise a dismutase, a catalase, and an electron acceptor, each of which contribute to either the maintenance of hemoglobin in the active oxygen carrying state or provide a benefit not achieved with free hemoglobin.Type: ApplicationFiled: June 28, 2011Publication date: November 21, 2013Applicant: THE GENERAL HOSPITAL CORPORATIONInventors: Martin L. Yarmush, Eric Yang, Tali Konry, Erkin Seker, Dhruv Sarin, Prakash Rai
-
Publication number: 20130259922Abstract: The present invention relates to the preparation of liposomes with enhanced loading capacity for pharmaceutically and/or diagnostically active agents and/or cosmetic agents which are substantially solubilized by the liposomal membranes, to liposome dispersions with enhanced stability with respect to release of the active agent and/or cosmetic agent from the liposomes obtainable by the process, and to pharmaceutical or cosmetic compositions comprising said stabilized liposome dispersions. The preparation may involve dehydration and rehydration steps of liposome dispersions which may be carried out by spray drying.Type: ApplicationFiled: May 20, 2011Publication date: October 3, 2013Applicant: MEDIGENE AGInventors: Heinrich Haas, Ursula Fattler
-
Patent number: 8506859Abstract: The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft gel capsules.Type: GrantFiled: February 28, 2012Date of Patent: August 13, 2013Assignee: Soft Gel Technologies, Inc.Inventor: Michael Fantuzzi
-
Publication number: 20130195965Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.Type: ApplicationFiled: March 5, 2013Publication date: August 1, 2013Applicant: PACIRA PHARMACEUTICALS, INC.Inventor: PACIRA PHARMACEUTICALS, INC.
-
Publication number: 20130189352Abstract: A liposome and preparation method thereof; the liposome is prepared from drugs, a phospholipid, a cholesterol-based compound, an internal buffering system and a pH adjusting agent; the drugs, the phospholipid and the cholesterol-based compound are in a weight ratio of 1:2-100:1-35; the drugs is a combination of a chloroquine-based drug and an adriamycin-based drug.Type: ApplicationFiled: November 23, 2011Publication date: July 25, 2013Applicant: ZHEJIANG UNIVERSITYInventors: Liyan Qiu, Mingfei Yao
-
Publication number: 20130183374Abstract: Disclosed are formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs which minimize the side effects of unencapsulated non-steroidal anti-inflammatory drugs while maintaining or improving efficacy. Methods of making and administering the formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs and their use as medicaments are also provided.Type: ApplicationFiled: March 6, 2013Publication date: July 18, 2013Applicant: PACIRA PHARMACEUTICALS, INC.Inventor: PACIRA PHARMACEUTICALS, INC.
-
Publication number: 20130183375Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.Type: ApplicationFiled: March 8, 2013Publication date: July 18, 2013Applicant: Pacira Pharmaceuticals, Inc.Inventor: Pacira Pharmaceuticals, Inc.
-
Publication number: 20130183373Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.Type: ApplicationFiled: March 6, 2013Publication date: July 18, 2013Applicant: PACIRA PHARMACEUTICALS, INC.Inventor: Pacira Pharmaceuticals, Inc.
-
Publication number: 20130183372Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.Type: ApplicationFiled: March 6, 2013Publication date: July 18, 2013Applicant: PACIRA PHARMACEUTICALS, INC.Inventor: PACIRA PHARMACEUTICALS, INC.
-
Publication number: 20130177636Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.Type: ApplicationFiled: March 6, 2013Publication date: July 11, 2013Applicant: Pacira Pharmaceuticals, Inc.Inventor: Pacira Pharmaceuticals, Inc.
-
Publication number: 20130177634Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.Type: ApplicationFiled: March 5, 2013Publication date: July 11, 2013Applicant: PACIRA PHARMACEUTICALS, INC.Inventor: PACIRA PHARMACEUTICALS, INC.
-
Publication number: 20130177638Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.Type: ApplicationFiled: March 6, 2013Publication date: July 11, 2013Applicant: PACIRA PHARMACEUTICALS, INC.Inventor: PACIRA PHARMACEUTICALS, INC.
-
Publication number: 20130177635Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.Type: ApplicationFiled: March 5, 2013Publication date: July 11, 2013Applicant: PACIRA PHARMACEUTICALS, INC.Inventor: PACIRA PHARMACEUTICALS, INC.
-
Publication number: 20130177598Abstract: A pharmaceutical composition comprising protein micro and/or nanoparticles are provided. The particles have a predetermined geometric shape and a broadest dimension less than about 10 micrometers. The particles may further comprise active agents.Type: ApplicationFiled: February 27, 2008Publication date: July 11, 2013Applicant: The University of North Carolina at Chapel HillInventors: Joseph M. Desimone, Stephanie Gratton, Ji Guo, Jennifer Yvonne Kelly, Andrew James Murphy, Mary E Napier