Having Specific Container Patents (Class 34/296)
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Publication number: 20150128445Abstract: The invention relates to an apparatus and a method of freezing a liquid substance contained in at least one receptacle, comprising the steps of: providing the liquid substance in at least one receptacle, providing a cooling chamber and a cooling device having a cooling surface; setting the temperature of the cooling surface, starting a freezing procedure by placing the receptacle with the liquid substance therein on the cooling surface to form a seed or initial zone of nucleation; and continuing the freezing procedure to completely freeze the substance.Type: ApplicationFiled: January 26, 2015Publication date: May 14, 2015Inventors: Juergen Dittrich, Guenther Ziegler
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Patent number: 8950609Abstract: A stopper device including a stopper, cap and ring provided with tabs for locking onto a container neck and a body for handling the ring. The body includes a first mechanism for transmitting a thrust force to the ring and a second mechanism for activating the tabs. The ring and the handling body are respectively provided with first and second retainers that hold the handling body in a waiting position. The handling body is mobile parallel to the thrust force direction and in relation to the ring, between a first position activating the tabs of the ring and is mobile in translation only in the thrust force direction, and a second position that also activates the tabs and is immobilized in relation to the ring in axial translation. The tabs extend from a continuous edge of the ring and are each arranged in an opening with a closed contour.Type: GrantFiled: November 23, 2011Date of Patent: February 10, 2015Assignee: West Pharmaceutical Services Deutschland GmbH & Co. KGInventor: Antoine Aneas
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Patent number: 8683712Abstract: A method of manufacturing a lyophilized reagent, including mounting a plurality of reagent cartridges in which a liquid reagent is loaded in a tray including one or more tunnel-shaped first rails having opened end portions in a lengthwise direction and an opening formed in the top of the one or more first rails; closing the opened end portions, placing the tray in a lyophilizer and lyophilizing the liquid reagent according to a lyophilizing program.Type: GrantFiled: October 6, 2009Date of Patent: April 1, 2014Assignee: Samsung Electronics Co., Ltd.Inventors: Do-gyoon Kim, Han-sang Kim, Jung-nam Lee
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Patent number: 8322046Abstract: A method of manufacturing heat-sensitive pharmaceutical powder is disclosed. The original pharmaceutical substances are dissolved in a solution or suspended in a suspension, which is sprayed through an atomizing nozzle and frozen in a cold gas phase or liquid nitrogen atomized directly in the spray-freeze chamber or gas jacket at the same time (for cooling purposes). The particles are freeze-dried at roughly atmospheric pressure in a down-stream fluid flow with exit filter thereby to remove moisture entrapped on or inside the frozen particles. The system has applicability for forming other powders.Type: GrantFiled: March 18, 2008Date of Patent: December 4, 2012Inventors: Zhaolin Wang, Warren H. Finlay
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Publication number: 20100236090Abstract: A multilayer plastic container for storing lyophilized products includes at least three layers consisting of inner and outer layers having a moisture vapor transmission rate of not more than 0.1 gm mil/100 sq. in.-day at 73° F. and 95% rh, and an intermediate layer of hygroscopic resin construction having a moisture content less than 1000 ppm. The hygroscopic intermediate layer preferably comprises at least 30% of the total thickness of the three layers. The inner and outer layers preferably are of cyclic olefin polymer or cyclic olefin copolymer construction, and the hygroscopic intermediate layer preferably is of amorphous nylon construction. The container preferably is empty and sealed within a secondary container, such as a metallized bag, that is impervious to moisture.Type: ApplicationFiled: June 1, 2010Publication date: September 23, 2010Inventor: Michael J. Grimm
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Publication number: 20080172902Abstract: A process of freeze drying of an essentially aqueous solution comprising at least one first step having a first temperature and pressure level (i.e. primary drying phase) and at least one second step having a second temperature and pressure level (i.e. secondary drying phase) following the first step, wherein in the secondary drying phase limited desorption energy input is applied.Type: ApplicationFiled: June 19, 2007Publication date: July 24, 2008Applicant: Octapharma AGInventors: Gerhard Gruber, Anton Reschny
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Patent number: 6941676Abstract: Disclosed is a freeze-drying apparatus for foodstuffs, medicaments, etc., wherein liquid material is directly and distributively poured into upright cylindrical tubes, then, in its isolated state from external atmosphere for perfect sterilization, the liquid material is frozen with uniform thickness onto inner wall surface of the tubes, with further possibility of uniform heating of the freeze-dried layer. The main body of this apparatus is constructed with upright cylindrical tubes for freezing liquid material onto inner surface of tubes and jackets to surround the outer periphery of each of the tubes in a substantially concentric cylindrical shape, within which to circulate heat medium; then, a duct communicating to the vacuum exhaust system is connected to the upper end side of these tubes, while, a recovery chamber provided with valve is connected to the lower end side of tubes; and an inlet port is defined for feeding liquid material into inner cavity of tubes.Type: GrantFiled: January 4, 2002Date of Patent: September 13, 2005Assignee: Kyowa Vacuum Engineering Co., Ltd.Inventors: Hiromichi Akimoto, Ryoji Sunama
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Patent number: 6904701Abstract: A device for holding substances during drying comprising a flask having a structure defining an opening. A pair of contiguous or juxtaposed filters is disposed in the opening. A freeze-drying assembly comprising a freeze-drying apparatus, and the device disposed in the apparatus for holding substances during freeze-drying processing. A method for processing a substance under sterile conditions comprising disposing a substance in a flask, positioning the flask in a drying apparatus, and passing a drying medium through a pair of juxtaposed filters for drying the substance.Type: GrantFiled: February 15, 2002Date of Patent: June 14, 2005Assignee: The Regents of The University of CaliforniaInventors: Thurein M. Htoo, John H. Crowe, Ann E. Oliver, Fern Tablin
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Patent number: 6745490Abstract: This invention is concerned with a distributive ejection apparatus for liquid material in a freeze-drying apparatus for foodstuffs, medicaments, etc., wherein the liquid material adjusted from the starting material for foodstuffs, medicaments, etc. is caused to freeze onto the inner wall surface of the upright cylindrical tube, and the distributive ejection of the liquid material onto the tube at the time of its freeze-drying by sublimation of the moisture content in the material under the vacuum condition may be done in the state of supplying the liquid material over the entire surface of the inner wall surface of the tube with a substantially uniform thickness.Type: GrantFiled: January 4, 2002Date of Patent: June 8, 2004Assignee: Kyowa Vacuum Engineering Co., Ltd.Inventors: Hiromichi Akimoto, Ryoji Sunama
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Patent number: 6543155Abstract: Freeze-dried products of high quality produced from materials to be freeze-dried in a freeze-drying apparatus comprising a sealed vessel enclosing a processing chamber provided therein with a rotary cage receiving a gas-permeable container containing frozen pieces of the said material, prepared by freezing the said material with a refrigerant, and a heating device for heating the frozen material by radiant heat rays, wherein the freeze-dried product is produced by a process which can attain, even when dry ice is used as the refrigerant, efficient sublimating removal of large amount of carbon dioxide gas evolved from dry ice and of moisture included in the material, while preventing adhesion of the frozen pieces of the said material to each other and while permitting reduction of the sublimation duration, wherein the frozen material retained in the gas-permeable container placed in the rotary cage is heated uniformly by the heating device under vacuum condition while it is being maintained under rotational movType: GrantFiled: September 20, 2002Date of Patent: April 8, 2003Assignee: National Agricultural Research OrganizationInventor: Akira Horigane
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Patent number: 6543154Abstract: Freeze-dried products of high quality produced from materials to be freeze-dried in a freeze-drying apparatus comprising a sealed vessel enclosing a processing chamber provided therein with a rotary cage receiving a gas-permeable container containing one or more frozen products of the said material, prepared by freezing the said material with dry ice, and a heating device for heating the frozen product by radiant heat rays, wherein the freeze-dried product is produced by a process which can attain efficient sublimating removal of large amount of carbon dioxide gas evolved from dry ice and of moisture included in the material, while preventing adhesion of the frozen products to each other and while permitting reduction of the sublimation duration, wherein the frozen product retained in the gas-permeable container placed in the rotary cage is heated uniformly by the heating device under vacuum condition while holding it under rotational movement to thereby facilitate the sublimation of dry ice and of the frozenType: GrantFiled: October 17, 2001Date of Patent: April 8, 2003Assignee: National Agricultural Research OrganizationInventor: Akira Horigane
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Patent number: 6212791Abstract: The invention permits the application of an identifying mark onto a fast-dissolving dosage form without the need for application of pressure or printing directly onto the dosage unit. The invention comprises preparing of a fast-dissolving dosage unit that is embossed with an identifying mark such as a manufacturer's logo, medicinal component strength, or other information relating to the unit. The desired identifying mark is first embossed onto the base of the container such as a blister pocket. Liquid suspension is then filled into the container and solidified, e.g., freeze-dried, therein. The resulting dosage unit in the container is thereby embossed with a substantial copy of the identifying mark that was embossed on the base of the container. The embossed identifying mark on the base of the container remains thereon as well thereby affording the ability to learn the identifying mark on the enclosed unit without opening the packet.Type: GrantFiled: March 31, 2000Date of Patent: April 10, 2001Assignee: R.P. Scherer CorporationInventors: Andrew R. Thompson, Richard J. Yarwood, Patrick Kearney
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Patent number: 5822882Abstract: A freeze dryer includes a freezer unit having a plurality of walls defining a freezer interior. A housing defining a chamber suitable for receiving a specimen to be freeze dried is mounted to one of the panels to extend through an aperture therein into the freezer interior. A lid engages the housing to seal the housing. A condenser and a pump are coupled to the housing to lower pressure in the chamber and to condense liquid from the specimen.Type: GrantFiled: July 23, 1996Date of Patent: October 20, 1998Assignee: Freezedry Specialties, Inc.Inventor: Alan R. Anger
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Patent number: 5596814Abstract: An vented vial stopper for use in processing freeze-dried products is provided. The stopper includes a vent passageway that is covered with a waterproof and moisture vapor permeable membrane to allow the venting of moisture during the freeze-drying process. The membrane also extends to cover most or all of the exposed surface of the stopper to protect the stopper from chemical attack during processing.Type: GrantFiled: November 6, 1995Date of Patent: January 28, 1997Assignee: W. L. Gore & Associates, Inc.Inventors: Ralph D. Zingle, Nelson A. George
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Patent number: 5501673Abstract: An injection cartridge of the dual-chamber type has a bypass connection between its two chambers which is arranged such that the interior wall of the cartridge is modified in a determined area in such a way that the movable wall between the two chambers does not seal completely against the interior wall in said area.Type: GrantFiled: December 8, 1994Date of Patent: March 26, 1996Assignee: Pharmacia ABInventors: Birger Hjertman, Gustav Levander, Olle Ljunquist
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Patent number: 5457895Abstract: The invention permits the application of an identifying mark onto a freeze-dried tablet without the need for application of pressure or for printing directly on the tablet. The invention comprises the preparation of a freeze-dried unit that is embossed with an identifying mark such as a manufacturer's logo, medicinal component strength, or other information relating to the unit. The desired identifying mark is first embossed onto the base of a container such as a blister pocket. Liquid suspension is then filled into the container and freeze-dried therein. The resulting freeze-dried unit in the container is thereby embossed with substantial copy of the identifying mark that was embossed on the base of the container. The embossed identifying mark on the base of the container remains thereon as well, providing at reduced manufacturing cost the added ability to learn the identifying mark on the enclosed freeze-dried unit without opening the blister pack.Type: GrantFiled: October 1, 1993Date of Patent: October 17, 1995Assignee: R. P. Scherer CorporationInventors: Andrew R. Thompson, Richard J. Yarwood, Patrick Kearney
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Patent number: 5435076Abstract: A device for an injection apparatus, including a dual-chamber injection cartridge. The cartridge includes a front end, a rear end, a front opening in the vicinity of a front end of the cartridge, a front chamber located in the vicinity of the front opening and including a drug freeze-dried in the front chamber, a rear chamber including a liquid component, a movable wall separating the front chamber and the rear chamber, a bypass for transferring the liquid component between the front chamber and the rear chamber, and a rear piston. The cartridge is slidably arranged within a cylindrical sleeve substantially the same length as the cartridge. A stopper is located in the vicinity of the front opening of the cartridge. The stopper is directed rearwardly coaxially with the cartridge, wherein as the sleeve is displaced rearwardly after the freeze-drying of the drug, the stopper enters the front opening of the cartridge to sealingly close the cartridge.Type: GrantFiled: November 24, 1993Date of Patent: July 25, 1995Assignee: Pharmacia AktiebolagInventors: Birger Hjertman, Gustav Levander, Olle Ljungquist