Abstract: A method for predicting an instant at which a predefined fatigue degree is expected to be reached in a vehicle system for fatigue detection, includes: (i) detecting the fatigue characteristic by continuously ascertaining the current fatigue degree of the vehicle operator; (ii) ascertaining a change in the fatigue degree over time within a predefinable time interval of the fatigue characteristic, and/or supplying an empirically determined change in fatigue degree over time; and (iii) ascertaining the instant at which a predefined fatigue degree is expected to be reached, based on the ascertained and/or supplied change in the fatigue degree.

Abstract: A sensor network may be configured to operate in extreme temperature environments. A sensor may be configured to generate a frequency carrier, and transmit the frequency carrier to a node. The node may be configured to amplitude modulate the frequency carrier, and transmit the amplitude modulated frequency carrier to a receiver.

Abstract: An iron redox flow battery system, comprising a redox electrode, a plating electrolyte tank, a plating electrode, a redox electrolyte tank with additional acid additives that may be introduced into the electrolytes in response to electrolyte pH. The acid additives may act to suppress undesired chemical reactions that create losses within the battery and may be added in response to sensor indications of these reactions.

Abstract: A pulse photometer includes a light emitter, a light detector, a first signal separator that separates a first signal component and a first noise component, a second signal separator that separates a second signal component and a second noise component, a first determining section, a second determining section, and a concentration calculating section that calculates a concentration of a light absorption material in blood of the subject based on a fundamental frequency of the first signal component or a fundamental frequency of the second signal component.

Abstract: An apparatus and method for non-invasively determining a blood oxygen parameter value of a subject's tissue is provided. An embodiment of the method includes the steps of: a) providing a spectrophotometric sensor that includes a processing portion and a transducer, b) detecting at least a portion of transmitted light after passage through the subject's tissue and producing initial signal data from the detected light; and c) using the processing portion to: (i) determine a value representative of an attenuation of at least one wavelength of light detected; (ii) determine whether the representative attenuation value is outside a predefined range of attenuation values; and (iii) determine the blood oxygen parameter value using a first interrogation or an alternate interrogation setting.

Abstract: Disclosed herein is a framework for facilitating patient signal analysis. In accordance with one aspect, first and second patient signal data are received from a patient monitor. The first and second patient signal data may then be segmented into respective first and second regions of interest, from which respective first and second waveform parameters may be extracted. One or more morphology indices may then be generated based on the first and second waveform parameters to compare shapes of the first and second regions of interest.

Abstract: A sensor device includes a flow path and a metal layer disposed in the flow path. The flow path is configured to allow a sample containing analytes to flow and to allow a carrier to be disposed therein. The carrier has acceptors that are fixed on a surface thereof and specifically bound with the analytes for producing aggregates. The flow path includes an aggregate trapping section at which the analytes locally concentrate to the section. This sensor device has high detection sensitivity with a simple structure.

Abstract: Embodiments disclosed herein may describe systems and methods for reducing nuisance alarms using probability and/or accuracy of a measured physiological parameter, such as the pulse rate or SpO2 measurement generated by a pulse oximeter. Embodiments may include methods for adjusting a predetermined alarm threshold based on the probability distribution of the estimated pulse rate and/or oxygen saturation of a patient's blood.

Abstract: Ruptured Abdominal Aortic Aneurysms (AAA) cause a large number of deaths annually. Ruptures occur even in people who are already diagnosed with AAA and are being monitored. The reason is that the interval between tests is too long because of the need to visit a pathological facility with imaging equipment. It is preferable to estimate the progress of AAA frequently, once detected, in a non-invasive manner, preferably at the subject's home, without the need for the subject to visit a pathological facility. A device is disclosed for detecting a state of a vascular pathology of a subject, comprising a sensor signal unit (103) for providing a signal representative of a blood volume in a body part of a subject, a comparator (107) for comparing the sensor signal with a reference signal, and a user interface (109) for conveying a result based on the comparison to a user of the device.

Abstract: Systems, methods, and devices of the various embodiments provide a device capable of determining a blood property based at least in part on the measurement of the amount of light received by a receiver circuit with a limited current capacity by charging a capacitor with a low voltage power supply and intermittently discharging the capacitor through a light emitting diode. In some embodiments the device may be a pulse oximeter capable of taking blood oxygen readings. In some embodiments the device may be a heart rate monitor to determine a heart rate based on an amount of light passed through tissue. The various embodiments may enable pulse oximeters and/or heart rate monitors to be incorporated into small unobtrusive body patches, while enabling the pulse oximeters to operate from a power output equivalent to that of a small coin cell battery or printed cell battery.

Abstract: A system and method of dynamically localizing a measurement of parameter characterizing tissue sample with waves produced by spectrometric system at multiple wavelengths and detected at a fixed location of the detector of the system. The parameter is calculated based on impulse response of the sample, reference data representing characteristics of material components of the sample, and path lengths through the sample corresponding to different wavelengths. Dynamic localization is effectuated by considering different portions of a curve representing the determined parameter, and provides for the formation of a spatial map of distribution of the parameter across the sample. Additional measurement of impulse response at multiple detectors facilitates determination of change of the measured parameter across the sample as a function of time.

Abstract: Apparatus and method for harvesting selected vessels in the body of a patient include manual manipulation of a rigid dissecting endoscope and the reconfiguration thereof to facilitate tissue dissection and tissue dilation in the formation of an anatomical space about the vessel within which side-branch vessels may be manipulated in preparation for severance and removal of the vessel from the anatomical space.

Abstract: An apparatus includes a sensor body, a circuit board, a cable, at least one light emitting device, and at least one photodetector. The circuit board is enclosed within the sensor body and includes at least one conductive trace and at least one aperture. The cable is coupled to the at least one conductive trace. The cable includes a shield conductor and a signal conductor. The at least one light emitting device is coupled to the circuit board and is configured to emit light into a tissue. The at least one photodetector includes a planar active area coupled to the circuit board and is configured to provide an output signal based on light detected by the active area. The planar active area is aligned with the aperture. The output signal is coupled to the cable.

Abstract: A physiological function detecting earphone includes an earphone body, an earplug mounted at one side of the earphone body and defining a window, a light processing module including a light sensing module towards the window, and a signal processing module. A detecting method using the earphone by a participant includes the steps of: the participant inserts the earplug in the ear canal thereof; the light sensing module senses the changes of light emitted through the window and then reflected by the wall of the ear canal; the light processing module processes the reflected light changes to get photoplethysmography (PPG) signals; and the signal processing module receives and processes the PPG signals to get physiological information of the participant.

Abstract: A method and system for optical measuring one or more vital signs of a human is described. The method includes generating an optical Pulse Width Modulated (PWM) signal modulated in accordance with a predetermined Pulse Width Modulation scheme. The PWM scheme includes one or more Pulse Width Modulations having different modulation frequencies. The method also includes applying the PWM optical signal to a measurement location in a blood perfused body tissue of the human and receiving light originated back from the measurement location. A photo current signal of a time response of the blood perfused body tissue to the PWM optical signal is indicative of the vital signs. The method includes generating a voltage signal from the photo current signal and processing the voltage signal for determining the vital signs.

Abstract: An apparatus for measuring capillary refill time has a measurement module containing at least two radiation sources and at least one detector configured to detect radiation from each source that interacts with and is received from a measurement region of a patient or subject. One radiation source may be characterized by a wavelength that is absorbed substantially equally by oxyhemoglobin and deoxyhemoglobin. The other radiation source may be substantially unaffected by the presence or absence of blood in the measurement region. The measurement module may be applied against a measurement region of a patient for a first time period, and the released from the measurement region for a second time period, and detected signals processed to quantitatively evaluate capillary refill time.

Abstract: A physiological information measuring apparatus includes a first detection unit, having a first light emitting unit and a first light receiving unit, separated from one another by a first distance. A second detection unit of the physiological information measuring apparatus has a second light emitting unit and a second light receiving unit, separated from one another by a second, different distance. Alternatively, the second detection unit shares the first light emitting unit with the first detection unit and has a second light receiving unit. Alternatively, the second detection unit shares the first light receiving unit with the first detection unit and has a second light emitting unit. A measuring unit of the physiological information measuring apparatus measures the physiological information of a user based on light received by the light receiving unit or light receiving units.

Abstract: Embodiments of the present invention comprise systems and methods for noninvasion measurements of physiological properties of tissues. The system comprises a light emitter, an optical detector, a mechanical sensor and a processor. The light emitter is capable of emitting light of at least two different wavelengths and comprises at least one light source. The processor is capable of evaluating physiological properties of the tissues from measurements of the optical and the mechanical sensor. More precisely, the processor is capable of evaluating physiological properties of venous blood by using data measured by the mechanical sensor and the optical detector. For example, the oxygenation of venous blood can be measured. Furthermore, the systems can optionally comprise a light emitter which emits three wavelengths and/or the light emitter and the optical detector are arranged in reflection geometry and are located at a distance of at most 10 mm from each other.

Abstract: A system for providing continuous monitoring of a patient includes: a first monitor device configured to measure one or more physiological attributes associated with the patient, the first monitor device being a contactless device; and a second monitor device configured to measure one or more physiological attributes associated with the patient, the second monitor device including one or more sensors contacting the patient; wherein, upon an alarm condition by the first monitor device, the second monitor device is configured to measure a physiological attribute and suppress the alarm condition when the second monitor device detects a non-alarm condition.

Abstract: Methods, devices and systems are provided for wirelessly powering and controlling a lab-on-a-chip device. Direct current (DC) and alternating current (AC) signals can be produced at the lab-on-a-chip device in a wireless manner. In some configurations, integrated RF components and optoelectronic components of the lab-on-a-chip device are used to collaboratively produce the DC and AC signals. In other configurations only optoelectronic components on the lab-on-a-chip system can produce the DC and/or AC signals in response to incident light. By modulating the incident light, AC signals of various frequencies and waveforms can be generated. The DC and AC signals can be used by additional integrated electronic circuits and by a microfluidic chip lactated on the lab-on-a-chip device to control the behavior of the bioparticles in the microfluidic device.

Abstract: The invention relates to a diagnostic measuring apparatus for non-invasively detecting at least one physiological parameter of the human body. The measuring apparatus comprises: —a continuum emitter (110) for emitting first electromagnetic radiation, the spectrum of which has a continuum extending over a wavelength range, —a bearing area for bearing a human body part (100) on the measuring apparatus, wherein the bearing area is designed such that the body part (100) is irradiated with the first electromagnetic radiation, wherein the first electromagnetic radiation is emitted by transmission, scattering and/or reflection as second electromagnetic radiation from the tissue of the body part (100), —a detector (102; 104) for detecting at least one spectral component of the second electromagnetic radiation, —a spectral decomposition unit (106; 114; 116; 402) for spectrally selecting wavelength ranges of the first and/or second electromagnetic radiation.

Abstract: A GoPro® pivoting/swivel mount that is securely integrated with high quality Mechanix® type gloves that are used for diving.

Abstract: According to the present invention, a method and apparatus for non-invasively determining the blood oxygen saturation level within a subject's tissue is provided. The method comprises the steps of: a) providing a spectrophotometric sensor operable to transmit light into the subject's tissue, and to sense the light; b) detecting light after passage through the subject's tissue using the sensor, and producing initial signal data from the light sensed; c) calibrating the sensor to that particular subject using the initial signal data, thereby accounting for the specific physical characteristics of the particular subject's tissue being sensed; and d) using the calibrated sensor to determine the blood oxygen parameter value within the subject's tissue.

Abstract: A system for in-situ spectroscopic measurements in heterogeneous catalytic reactors includes a reactor having a reactor chamber, a device for collecting a sample, and a device for collecting spectroscopic information. The device for collecting the sample includes a sampling capillary having an orifice situated inside the reactor chamber. The device for collecting spectroscopic information includes at least one optical radiation guide for guiding optical radiation onto the sample for excitation and for collecting optical radiation emitted, absorbed, reflected or scattered by the sample. The at least one optical radiation guide may be inserted into the sampling capillary, such that a tip of the at least one optical radiation guide is proximate to the orifice. A method for analyzing a reactor state including the steps of providing a reactor; collecting spectroscopic information from a sample inside the reactor chamber; and analyzing the collected spectroscopic information is also provided.

Abstract: Automated critical congenital heart defect (“CCHD”) screening systems and processes are described. A caregiver may be guided to use a single or dual sensor pulse oximeter to obtain pre- and post-ductal blood oxygenation measurements. A delta of the measurements indicates the possible existence or nonexistence of a CCHD. Errors in the measurements are reduced by a configurable measurement confidence threshold based on, for example, a perfusion index. Measurement data may be stored and retrieved from a remote data processing center for repeated screenings.

Abstract: An optical sensor device includes a light emitter for emitting, to a living body, lights having two wavelengths and blinking at a predetermined frequency, and a light receiver for receiving the lights from the living body. The light receiver outputs first and second detection signals corresponding to the respective wavelengths. A filter circuit extracts, from the first and second detection signals, modulation signals that are obtained with amplitude modulation of signals of the predetermined frequency. The modulation signals are amplified by a post-amplifier and are taken into an arithmetic processing unit after being converted to digital signals by an AD converter. The arithmetic processing unit calculates DC components and AC components of the first and second detection signals by employing the modulation signals converted the digital signals.

Abstract: A physiological monitor for determining blood oxygen saturation of a medical patient includes a sensor, a signal processor and a display. The sensor includes at least three light emitting diodes. Each light emitting diode is adapted to emit light of a different wavelength. The sensor also includes a detector, where the detector is adapted to receive light from the three light emitting diodes after being attenuated by tissue. The detector generates an output signal based at least in part upon the received light. The signal processor determines blood oxygen saturation based at least upon the output signal, and the display provides an indication of the blood oxygen saturation.

Abstract: A method for adjusting, calibrating and/or checking a function of a photometric sensor, which is embodied for measuring at least one measured variable in a medium, wherein the sensor works with at least one measuring wavelength and at least one reference wavelength, comprising the steps as follows: mounting a calibration insert in a receptacle provided therefor at the sensor, adjusting, calibrating and/or performing the function check, and removing the calibration insert, characterized in that the transmittance of light of the measuring wavelength and the transmittance of light of the reference wavelength through the calibration insert are different. The invention relates further to a calibration insert.

Abstract: A process cartridge detachably mountable to an image forming apparatus includes a rotatable developer carrying member, a rotatable developer feeding member, a rotatable developer stirring member, a developer carrying member gear, a developer feeding member gear, a developer stirring member gear, a transmission member for transmitting a driving force to the developer carrying member, the developer feeding member and the developer stirring member, wherein the transmission member includes a first gear for transmitting the driving force to the developer carrying member gear, a second gear for transmitting the driving force to the developer feeding member gear, and a third gear for transmitting the driving force to the developer stirring member gear, in which the first gear, the second gear and the third gear are integrally molded.

Abstract: A connector of a sensor probe and its receptacle on a console have security mechanisms that ensure that the connector and the receptacle are properly connected and mated. The connector and receptacle can have physical security features that block insertion of the connector into the receptacle if they are not aligned in a proper orientation. The console can also include a software security feature that allows optical measurements from the sensor probe only if the connector of the sensor probe and receptacle on the console are connected properly. An adapter can also be used to convert a conventional receptacle mounted on a console into a receptacle with security features.

Abstract: A controller for optical components. A controller includes an analog interface that is configured to connect to an optical component external to the controller. The analog interface is able to deliver and/or receive signals to and/or from the optical component. The controller includes a digital interface that is able to connect to a memory external to the controller. The digital interface may receive a digital representation of operating characteristics of the optical component. The controller is configured to deliver and/or receive signals to and/or from the optical component based on the digital representation of operating characteristics.

Abstract: A proximity detection system is described among devices in a unified communications network. A narrow beam LED and a diffuse beam LED, both located near a first object, such as a computer monitor, provide a light illumination pattern detected by a narrow beam light detector and a broad beam light detector, both located near a second device, such as a headset. A processor calculates the ratio of measured intensity from the narrow beam LED compared to the broad beam LED as measured by the broad beam detector to provide an estimate for how far off axis the second object (e.g., a user of the headset) is with respect to the centerline in front of the second object (e.g., the computer monitor). The processor also calculates the ratio of measured intensity of the narrow IR beam detector to the broad IR beam detector to provide an estimate of the second object's orientation (e.g., the headset user's head) with respect to the first object to determine if the second object is facing the first object.

Abstract: A whole blood immunity measuring device includes a hemolytic reagent supply device that supplies a hemolytic reagent to a whole blood sample, a first light source that irradiates light on a first blood sample as being the whole blood sample to which the hemolytic reagent is added, a first light detection device that detects transmitted first light intensity, and a Hgb calculation part that calculates concentration of hemoglobin based on the first light intensity. An immunoreagent supply device supplies an immunoreagent to the first sample, a whole second light source irradiates light on a second blood sample as being the first sample to which the immunoreagent is added. A second light detection device detects transmitted second light intensity, and a measuring object calculation part that calculates a concentration of the measuring object based on the second light intensity.

Abstract: The present invention involves method and apparatus for analyzing two measured signals that are modeled as containing primary and secondary portions. Coefficients relate the two signals according to a model defined in accordance with the present invention. In one embodiment, the present invention involves utilizing a transformation which evaluates a plurality of possible signal coefficients find appropriate coefficients. Alternatively, the present invention involves using statistical functions or Fourier transform and windowing techniques to determine the coefficients relating to two measured signals. Use of this invention is described in particular detail with respect to blood oximetry measurements.

Abstract: An analyte meter for an analyte test strip includes a light source configured to emit a light having a wavelength substantially similar to the maximum absorption band of Hb, an optics assembly configured to direct the light emitted by the light source to a test strip, and a photodetector configured to quantitatively detect light emanating from the test strip and to generate a signal correlating to an analyte concentration in the test strip.

Abstract: The present disclosure is directed towards embodiments of systems and methods for discriminating (e.g., masking out) scale bands that are determined to be not of interest from a scalogram derived from a continuous wavelet transform of a signal. Techniques for determining whether a scale band is not of interest include, for example, determining whether a scale band's amplitude is being modulated by one or more other bands in the scalogram. Another technique involves determining whether a scale band is located between two other bands and has energy less than that of its neighboring bands. Another technique involves determining whether a scale band is located at about half the scale of another, more dominant (i.e., higher energy) band.

Abstract: An optical waveguiding optical format enables consistent optical analysis of small sample volumes. The optical format is comprised of an illumination light guide, a read window upon which a sample is placed, a sample collection needle or capillary, and a detection guide. Light redirecting facets are provided within the format itself such that the format serves as a unitary component for accepting light, directing light through a sample, and emitting light for detection.

Abstract: The present disclosure is directed towards embodiments of systems and methods for discriminating (e.g., masking out) scale bands that are determined to be not of interest from a scalogram derived from a continuous wavelet transform of a signal. Techniques for determining whether a scale band is not of interest include, for example, determining whether a scale band's amplitude is being modulated by one or more other bands in the scalogram. Another technique involves determining whether a scale band is located between two other bands and has energy less than that of its neighboring bands. Another technique involves determining whether a scale band is located at about half the scale of another, more dominant (i.e., higher energy) band.

Abstract: According to embodiments, techniques for using continuous wavelet transforms and spectral transforms to identify pulse rates from a photoplethysmographic (PPG) signal are disclosed. According to embodiments, candidate pulse rates of the PPG signal may be identified from a wavelet transformed PPG signal and a spectral transformed PPG signal. A pulse rate may be determined from the candidate pulse rates by selecting one of the candidate pulse rates or by combining the candidate pulse rates. According to embodiments, a spectral transform of a PPG signal may be performed to identify a frequency region associated with a pulse rate of the PPG signal. A continuous wavelet transform of the PPG signal at a scale corresponding to the identified frequency region may be performed to determine a pulse rate from the wavelet transformed signal.

Abstract: Systems and sensor clip assemblies for optically monitoring blood flowing through a blood chamber are provided. A sensor clip assembly includes emitters and photodetectors positioned on opposing arms, a signal conditioning circuit for conditioning raw analog signals generated by the photodetectors while the sensor clip assembly is fastened to a blood chamber, and an analog-to-digital converter for converting the conditioned analog signals to raw digital data. The sensor clip assembly may output the raw digital data to an external device and receive synchronized control signals from the external device, or the sensor clip assembly may include a microcontroller for performing calculations on the raw digital data and providing synchronized control signals internally. Parameters of blood flowing through the blood chamber such as hematocrit, oxygen saturation, and change in blood volume may be calculated from the raw digital data derived from the raw analog signals generated by the photodetectors.

Abstract: A method and apparatus are disclosed that reduces variation in radiation therapy treatment planning among plurality of users within the same or different geographic locations. The system includes a method and an apparatus that provide users with the knowledge information and utilizing the knowledge information to contour target volumes for radiation treatment planning. The mode of operation includes utilizing a stand-alone workstation or a server computer connected to the plurality of thin client workstations.

Abstract: A sensor clip assembly for an optical blood monitoring system includes a circuit board with a microprocessor that is programmed with a ratiometric model to calculate hematocrit and/or oxygen saturation levels of a patient.

Abstract: The present disclosure describes the use and the manufacture of a fiber optic sensor having an angled terminal portion of a fiber optic element. In one embodiment, an optical fiber is cut at an angle and a portion of the fiber's jacket is removed near the angle so that the cladding is exposed. Light may then travel through the fiber, reflect off the angled portion, and emit through the exposed cladding into a patient. Light may also be collected from the patient using the same or a different fiber optic element having an angled terminal portion. In one embodiment, the emitted light can then be collected and analyzed to derive various physiological parameters. In certain embodiments, the fiber optic sensor may be used in environments where metallic and/or electronic sensors are not suitable.

Abstract: The systems and methods described herein provide for fast and accurate image segmentation through the application of a multi-stage classifier to an image data set. An image processing system is provided having a processor configured to apply a multi-stage classifier to the image data set to identify a distinctive region. The multi-stage classifier can include two or more component classifiers. The first component classifier can have a sensitivity level configured to identify one or more target regions in the image data set and the second component classifier can have a specificity level configured to confirm the presence of the distinctive region in any identified target regions. Also provided is a classification array having multiple multi-stage classifiers for identification and confirmation of more than one distinctive region or for the application of different classification configurations to the image data set to identify a specific distinctive region.

Abstract: The present disclosure is directed towards embodiments of systems and methods for discriminating (e.g., masking out) scale bands that are determined to be not of interest from a scalogram derived from a continuous wavelet transform of a signal. Techniques for determining whether a scale band is not of interest include, for example, determining whether a scale band's amplitude is being modulated by one or more other bands in the scalogram. Another technique involves determining whether a scale band is located between two other bands and has energy less than that of its neighboring bands. Another technique involves determining whether a scale band is located at about half the scale of another, more dominant (i.e., higher energy) band.

Abstract: A method and system are presented for use in determination of the concentration of an analyte in a subject's medium. The medium is irradiated with at least two radiation components to produce detectable radiation responses of the medium thereto. These at least two radiation components are selected to have different mean wavelengths and such that the spectral bandwidth of at least one of said at least two radiation components is characterized by relatively high variability of the extinction coefficient of the analyte of interest across said spectral bandwidth. This enables analysis of data indicative of detected radiation responses of the medium to said at least two radiation components and determination of the concentration of said analyte.

Abstract: Techniques for the display of a signal with a wavelet transform of that signal in a wavelet transform viewer are disclosed, according to embodiments. According to embodiments, the wavelet transform viewer can display a plot of physiological signals such as a photoplethysmograph (PPG) signal. A portion of the plot of the signal can be selected. A wavelet transform the selected portion of the signal can be calculated and a wavelet plot of the tranformed signal can be displayed simultaneously with that signal. A plot of the selected portion of the signal can also be simultaneously displayed with both the plot of the signal and the wavelet plot.

Abstract: A light modifying ceramic composition comprises an oxygen permeable sol-gel matrix and a lumophore held on the matrix. In particular, the lumophore of the invention is a hexanuclear molybdenum/tungsten core having 12 anionic ligands and two ligands that are uncharged. Uncharged ligands include organic nitriles, organic phosphines, and organic arsines. In one embodiment, the ceramic composition containing the lumophore and the sol-gel matrix is applied to the end of an optical fiber to provide a remote oxygen sensor. The sensors are useful for in situ biological monitoring of oxygen either in vivo or in vitro, and in time dependent control of combustion processes such as an automobile or power plant.

Abstract: An optical measurement instrument for a living body to measure dynamic change of blood of a brain includes light incident units for irradiating light on a head of a subject, a light detector for detecting a light irradiated from the light incident units and reflected within the subject, a signal processing unit for calculating a spacious distribution of signals from the subject to be measured from a signal detected by the light detector, and a display for displaying the spacious distribution of signals from the subject to be measured. Measurement points are arranged about a middle of the light incident units and the light detector, and the light incident units and the light detector are arranged such that the measurement points are arranged to form a lattice whose circumference is square.

Abstract: An oximeter for spectro-photometric in-vitro determination of hemoglobin derivatives in a sample, typically a hemolyzed blood sample, is provided comprising a single measurement light source emitting measurement radiation, a sample chamber, for instance a measurement cuvette containing the sample, a detector device, which records a spectrum of the measurement radiation after its interaction with the sample, and an evaluation unit following the detector device, which determines the hemoglobin derivatives and at least one further analyte from the spectrum recorded by the detector device.