Therapy Patents (Class 378/65)
  • Patent number: 11964170
    Abstract: A standardized artificial intelligence automatic radiotherapy planning method includes acquiring a medical image; automatically delineating an ROI area of the medical image to acquire a geometric anatomical structure; determining a prescription according to disease type information corresponding to the medical image, the geometric anatomical structure, and a preset disease-prescription template library, and determining a radiation angle of radiation therapy; obtaining a radiation therapy dose distribution result using a dose prediction model; performing optimization processing using a reverse optimization algorithm based on dose distribution or DVH guidance, with reference to the radiation dose distribution result, to generate executable radiation therapy plans.
    Type: Grant
    Filed: May 22, 2020
    Date of Patent: April 23, 2024
    Assignee: BEIJING LINKING MEDICAL TECHNOLOGY CO., LTD.
    Inventors: Gui Li, Qiang Li, Weiyang Fan, Hua Zhang
  • Patent number: 11954848
    Abstract: The invention relates to a method and an installation for automatically measuring linear dimensions of manufactured objects (2) of a series comprising: the disposition of at least one focal point (Fj) of X-rays, on a same base straight line parallel to the rectilinear trajectory of displacement of the objects and of one or several image sensors (Ci); the acquisition, for each object during its displacement, of a set of one-dimensional images comprising, for a number (NK) of distinct section planes (Pk) containing the base straight line, a number (NP) of said images obtained along at least three different directions of projection (Dijk) in the section plane; for each object, and for each distinct section plane (Pk), the determination, from the images obtained, of a delineation of the object in the considered section plane (Pk).
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: April 9, 2024
    Assignee: TIAMA
    Inventors: Olivier Colle, Benoit Cance, Laurent Cosneau, Laurent Desbat, Emanuel Maitre, Nicolas Szafran
  • Patent number: 11950943
    Abstract: The disclosure relates to a patient support device (10) that is connectable to a positioning system (12), such as a multi-joint robot (16), the patient support device (10) comprising: a patient support region (18), comprising a front area (22) which defines a support plane (S) for supporting and/or contacting a patient (P) and an underside area (23) substantially facing away from the front area (22); and a coupling region (26) that is configured to be coupled to the positioning system (12), wherein the support plane (S) at least partially extends between the coupling region (26) and the underside area (23). The disclosure further relates to a patient positioning arrangement comprising such a patient support device (10) and positioning system (12).
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: April 9, 2024
    Assignee: BIZLINK INDUSTRY GERMANY GMBH
    Inventors: Samuel Pinault, Claude Burlot
  • Patent number: 11938346
    Abstract: A particle beam therapy apparatus has a position and posture setter that moves a movable body, that is at least one of the irradiation nozzle and the treatment table. A movement path of the movable body is determined when adapting the positional posture of the movable body from one condition among a plurality of prescribed conditions to another condition. An evaluation value is obtained for adapting the positional posture of the movable body to each of a plurality of prescribed conditions. This evaluation value is for a case of moving the movable body according to the movement path. A setting order is determined for adapting the positional posture of the movable body to each prescribed condition based on the evaluation value; and the positional posture of the movable body is adapted to each of the plurality of prescribed conditions by moving the movable body according to the determined movement path.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: March 26, 2024
    Assignee: HITACHI, LTD.
    Inventors: Hiroki Takahashi, Masanori Suzuki, Takuto Yagihashi, Takeshi Fujita, Isao Furuse, Yuko Okada
  • Patent number: 11938342
    Abstract: In one embodiment, a method includes receiving treatment information relating to a treatment plan for proton- or ion-beam therapy intended to irradiate a target tissue; receiving machine-limitation information relating to one or more limitations of one or more machines involved in the proton- or ion-beam therapy; determining a time-optimized beam current for a proton or ion beam based on the treatment information and the machine-limitation information, wherein the time-optimized beam current minimizes the time required to deliver a required quantity of monitor units to one of a plurality of spots, wherein each of the plurality of spots is a particular area of the target tissue; and delivering the time-optimized beam current to the particular area.
    Type: Grant
    Filed: February 2, 2022
    Date of Patent: March 26, 2024
    Assignee: VARIAN MEDICAL SYSTEMS PARTICLE THERAPY GMBH & CO. KG
    Inventors: Holger Goebel, Isabel Huth
  • Patent number: 11918829
    Abstract: Embodiments of the present disclosure provide a method, controller, and system for controlling a dose in radiotherapy of a patient and a computer storage medium. The method includes: starting to time radiation of rays or calculate radiation dose of the rays before a source carrier is aligned with a collimator in a process of aligning of the source carrier and the collimator; irradiating rays to a target area of the patient through the collimator till the radiation dose of the rays received by the patient is equal to a radiation dose required for the radiotherapy. Therefore, the radiation dose of the rays received by the patient in an entire treatment process may reach the radiation dose actually required during the radiotherapy, thereby improving a radiation dose control accuracy and a treatment effect during the radiotherapy.
    Type: Grant
    Filed: September 14, 2021
    Date of Patent: March 5, 2024
    Assignees: OUR UNITED CORPORATION, Shenzhen OUR New Medical Technologies Development Co., Ltd.
    Inventor: Xiaojuan Wen
  • Patent number: 11904188
    Abstract: Provided is a fully-spherical radiation therapy system. The fully-spherical radiation therapy system includes a multi-degree-of-freedom robot, a linear accelerator and a double-image-guided positioning mechanism. The double-image-guided positioning mechanism includes four ray sources and two ray detectors, and the four ray sources include a first ray source, a second ray source, a third ray source and a fourth ray source. An intersection of two beams emitted by the first ray source and the second ray source is a low-level treatment center, an intersection of two beams emitted by the third ray source and the fourth ray source is a high-level treatment center, and the low-level treatment center and the high-level treatment center form a fully-spherical treatment space for multiple treatment nodes of a spherical center.
    Type: Grant
    Filed: July 26, 2022
    Date of Patent: February 20, 2024
    Assignee: BEIJING RAYER SHIWEI MEDICAL RESEARCH CO., LTD
    Inventors: Dongshan Fu, Zhenyu Gu, Yabo Wang, Lujun An
  • Patent number: 11904186
    Abstract: The invention provides a radiotherapeutical or radiosurgical system comprising at least two high-intensity radiation sources configured to rotate around a common rotation axis and a ring-shaped imaging device. A three-source configuration is considered as the most cost-effective and will be used as an example for illustration. The configuration of these high-intensity radiation sources and use of a unique compact MLC for each of the radiation sources make it possible for the system to rapidly deliver high-conformal non-coplanar stereotactic radiation treatment in one gantry rotation without any couch rotation. Therefore the invention can deliver high precision and high-conformal non-coplanar stereotactic radiation treatment to any part of the body in an extremely short time (0.1-20 seconds), which may exhibit numerous advantages over the prior art, such as reduction of radiation damage to the circulating immune cells in blood and mitigation of patient motion-induced problems, among others.
    Type: Grant
    Filed: January 12, 2022
    Date of Patent: February 20, 2024
    Assignees: Capital Medical University, The University of Hong Kong—Shenzhen Hospital
    Inventors: Jianyue Jin, Fengming Kong
  • Patent number: 11904181
    Abstract: Methods and systems for selection of dosimetry levels and sphere amounts of radioactive compounds for use in a radioembolization procedure for procedure planning may include inputting activity parameter information into a dosimetry portal of a dosimetry selection tool; determining a customized activity based on the activity parameter information and one or more customized activity algorithms; generating one or more sphere amount and dosage recommendations based on the customized activity and one or more dosimetry selection algorithms; selecting one of the one or more sphere amount and dosage recommendations as a selected sphere amount and dosage recommendation; and generating a radioactive compound order for the radioembolization procedure based on the customized activity and the selected sphere amount and dosage recommendation.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: February 20, 2024
    Assignee: Bard Peripheral Vascular, Inc.
    Inventors: Casey Tyler Hebert, Mark Nicholas Wright, Lee Pusateri, Christopher Basciano, Sivaramakrishnan Balasubramanian
  • Patent number: 11904184
    Abstract: A radiation therapy system comprising a therapeutic radiation system (e.g., an MV X-ray source, and/or a linac) and a co-planar imaging system (e.g., a kV X-ray system) on a fast rotating ring gantry frame. The therapeutic radiation system and the imaging system are separated by a gantry angle, and the gantry frame may rotate in a direction such that the imaging system leads the MV system. The radiation sources of both the therapeutic and imaging radiation systems are each collimated by a dynamic multi-leaf collimator (DMLC) disposed in the beam path of the MV X-ray source and the kV X-ray source, respectively. In one variation, the imaging system identifies patient tumor(s) positions in real-time. The DMLC for the imaging radiation source limits the kV X-ray beam spread to the tumor(s) and/or immediate tumor regions, and helps to reduce irradiation of healthy tissue (e.g., reduce the dose-area product).
    Type: Grant
    Filed: November 9, 2022
    Date of Patent: February 20, 2024
    Assignee: RefleXion Medical, Inc.
    Inventor: Manat Maolinbay
  • Patent number: 11896310
    Abstract: An ophthalmologic information processing apparatus includes an analyzer, a storage unit, and a display controller. The analyzer is configured to specify an atrophy region in a fundus by analyzing data of the fundus of a subject's eye acquired using optical coherence tomography. The storage unit stores image data of the fundus. The display controller is configured to cause a fundus image of the subject's eye to be displayed on a display means based on the image data stored in the storage unit, and to cause a region corresponding to the atrophy region in the fundus image to be displayed on the display means so as to be identifiable.
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: February 13, 2024
    Assignee: TOPCON CORPORATION
    Inventors: Kanichi Tokuda, Taiki Aimi
  • Patent number: 11883127
    Abstract: In a method for synchronous magnetic resonance (MR) imaging and radiation therapy using a combined system having a radiation apparatus and an MR imaging apparatus, wherein the system is designed to record MR signals of a subject during irradiation of the subject, a three-dimensional MR volume data set of the subject is acquired that contains a target volume for the irradiation, the location of a central beam of the radiation therapy apparatus relative to the subject, is continuously determined, and a second MR image data set is determined, which is positioned essentially perpendicular to the central beam. If the location of the central beam changes, a correspondingly changed second MR image data set is determined perpendicular to the central beam.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: January 30, 2024
    Assignee: Siemens Healthcare GmbH
    Inventors: David Grodzki, Arne Hengerer, Sebastian Schmidt
  • Patent number: 11883687
    Abstract: A radiation treatment system may include a gantry configured to rotate around an object, a treatment head moving with the gantry, a plurality of imaging radiation sources configured to emit imaging beams toward the object, and one or more first detectors configured to detect at least a portion of the imaging beams. When the treatment head is delivering a treatment beam to the object, the plurality of imaging radiation sources and the one or more first detectors may be positioned outside at least a portion of a maximum treatment radiation region so as not to interfere with the treatment beam. At least one of the plurality of imaging radiation sources and the one or more first detectors may be positioned at or near an edge of the maximum treatment radiation region.
    Type: Grant
    Filed: September 8, 2020
    Date of Patent: January 30, 2024
    Assignee: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.
    Inventors: Jonathan Maltz, Johannes Stahl, Supratik Bose, Walter Aguilar
  • Patent number: 11883211
    Abstract: The disclosure relates to techniques for triggering magnetic resonance data acquisition. The techniques include detecting a respiration direction of a respiration signal of an acquisition subject, predicting in real time an amplitude peak value of an expiration signal in the current respiration period according to the real-time respiration signal of the acquisition subject, multiplying the amplitude peak value by a preset coefficient, and using the product as a trigger point threshold of the current respiration period. When it is determined that an expiration stage of the current respiration period is starting, the techniques also include calculating in real time or periodically the absolute value of the difference between the amplitude of the current expiration signal and the trigger point threshold currently calculated, and if the absolute value of the difference is less than a preset difference threshold, then triggering MR data acquisition.
    Type: Grant
    Filed: June 3, 2021
    Date of Patent: January 30, 2024
    Assignee: Siemens Healthcare GmbH
    Inventors: Jin Qiang He, Fang Dong, De He Weng
  • Patent number: 11877805
    Abstract: A method of trajectory planning for a medical robot system is disclosed herein, wherein a pose of a first component of the robot system may be changed independently of a pose of a second component of the robot system. The method includes determining an initial status, wherein, for each degree of freedom, an initial value is measured. Based on the initial status, items of position information of at least two discrete reference points of the first component in respect of one another are determined as well as further items of position information of at least two discrete further reference points of the second component in respect of one another. Depending on the initial status, the items of position information and the further items of position information, a trajectory for the robot system is planned, which transfers the robot system from the initial status into a target status.
    Type: Grant
    Filed: February 15, 2023
    Date of Patent: January 23, 2024
    Assignee: Siemens Healthcare GmbH
    Inventor: Ankit Patel
  • Patent number: 11878189
    Abstract: A computer-implemented method of performing a treatment fraction of radiation therapy comprises: determining a current position of a target volume of patient anatomy; based on the current position of the target volume, computing an accumulated dose for non-target tissue proximate the target volume; determining that the accumulated dose is less than a current value for a dose budget of the non-target tissue; and in response to the accumulated dose being less than the current value for the dose budget, applying a treatment beam to the target volume while the target volume is in the current position.
    Type: Grant
    Filed: August 31, 2022
    Date of Patent: January 23, 2024
    Assignee: SIEMENS HEALTHINEEERS INTERNATIONAL AG
    Inventors: Nasim Givehchi, Claas Wessels, Toon Roggen, Pascal Paysan, Marius Heinrich Walter Koehl, Stefan Georg Scheib
  • Patent number: 11872063
    Abstract: A method for determining a deformation measurement of a couch in a medical procedure may include determining a first deformation measurement of the couch at a reference point, the first deformation measurement corresponding to a first working position of the couch. The method may also include determining a second deformation measurement of the couch at the reference point, the second deformation measurement corresponding to a second working position of the couch. The method may further include determining a difference between the first deformation measurement and the second deformation measurement and causing an adjustment of one of the first working position and the second working position of the couch based on the difference between the first deformation measurement and the second deformation measurement.
    Type: Grant
    Filed: January 4, 2021
    Date of Patent: January 16, 2024
    Assignee: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.
    Inventors: Johannes Stahl, Supratik Bose, Li Wang
  • Patent number: 11872411
    Abstract: A newly developed algorithm and software can effectively and accurately predict the collisions for the accelerator, phantom, and patient setups, and can help physicians to choose the noncolliding and optimized beam sets efficiently via offering the ideal hits of planning target volume (PTV) and constraints of organ at risks (OARs).
    Type: Grant
    Filed: February 25, 2022
    Date of Patent: January 16, 2024
    Inventor: Yu-Jen Wang
  • Patent number: 11869120
    Abstract: A system and method for image reconstruction are provided. A first region of an object may be determined. The first region may correspond to a first voxel. A second region of the object may be determined. The second region may correspond to a second voxel. Scan data of the object may be acquired. A first regional image may be reconstructed based on the scan data. The reconstruction of the first regional image may include a forward projection on the first voxel and the second voxel and a back projection on the first voxel.
    Type: Grant
    Filed: April 18, 2022
    Date of Patent: January 9, 2024
    Assignee: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.
    Inventors: Yang Lyu, Yu Ding
  • Patent number: 11869680
    Abstract: A control circuit optimizes a radiation treatment plan for a patient treatment volume using an automatically iterating optimization process that optimizes as a function, at least in part, of predetermined cost functions, wherein at least one of the cost functions favors apertures for the multi-leaf collimation system having local curvature that deviates only minimally from a reference curvature. By one approach the control circuit determines the reference curvature as a function, at least in part, of at least one of setting the reference curvature to a static minimal local curvature, a shape of a projective mapping of the treatment volume onto an isocenter plane, and/or a fluence map associated with an amount of radiation to be administered to the treatment volume from a particular direction. By one approach the control circuit dynamically determines when to employ one or more such cost functions.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: January 9, 2024
    Assignee: Varian Medical Systems International AG
    Inventors: Santtu T.T. Ollila, Janne I. Nord, Jarkko Y. Peltola
  • Patent number: 11865363
    Abstract: The present disclosure generally relates to the field of radiation treatment. More specifically, the present disclosure generally relates to methods and radiation treatment systems for facilitating a multimodal radiation therapy treatment plan, in particular a multimodal radiation therapy plan employing a combined photon beam and electron beam radiation treatment. According to one example embodiment described in the disclosure, a method may comprise obtaining information related to a set of candidate beam types for the combined photon beam and electron beam radiation treatment; comparing the set of candidate beam types against a selection criterion to establish a subset of beam types from the candidate beam types; and generating the combined photon beam and electron beam radiation treatment plan utilizing the thus established subset of beam types.
    Type: Grant
    Filed: May 27, 2019
    Date of Patent: January 9, 2024
    Assignee: RaySearch Laboratories AB
    Inventors: Rasmus Bokrantz, Albin Fredriksson, Kjell Eriksson, Erik Engwall, Erik Traneus
  • Patent number: 11865368
    Abstract: The present invention relates to a medical data processing method of determining the representation of an anatomical body part (2) of a patient (1) in a sequence of medical images, the anatomical body part (2) being subject to a vital movement of the patient (1), the method being constituted to be executed by a computer and comprising the following steps: a) acquiring advance medical image data comprising a time-related advance medical image comprising a representation of the anatomical body part (2) in a specific movement phase; b) acquiring current medical image data describing a sequence of current medical images, wherein the sequence comprises a specific current medical image comprising a representation of the anatomical body part (2) in the specific movement phase, and a tracking current medical image which is different from the specific current medical image and comprises a representation of the anatomical body part (2) in a tracking movement phase which is different from the specific movement phase;
    Type: Grant
    Filed: March 17, 2023
    Date of Patent: January 9, 2024
    Assignee: BRAINLAB AG
    Inventors: Kajetan Berlinger, Stephan Froehlich
  • Patent number: 11857805
    Abstract: Systems and methods provide a radiotherapy treatment by focusing an electron beam on an x-ray target (e.g., a tungsten plate) to produce a high-yield x-ray output with improved field shaping. A modified electron beam spatial distribution is employed to scan the x-ray target, such as a 2D periodic beam path, which advantageously lowers the temperature of the x-ray target compared to typical compact beam spatial distribution. As a result, the x-ray target can produce a high yield x-ray output without sacrificing the life span of the x-ray target. The use of a 2D periodic beam path allows a much colder x-ray target functioning regime such that more dosage can be applied in a short period of time compared to existing techniques.
    Type: Grant
    Filed: April 9, 2021
    Date of Patent: January 2, 2024
    Assignee: VARIAN MEDICAL SYSTEMS, INC.
    Inventors: Anuj Purwar, Dragos Constantin, James Clayton
  • Patent number: 11861845
    Abstract: Systems, methods, and computer software are disclosed for acquiring images during delivery of a radiation beam, the images capturing at least a portion of a shape representative of a radiation field generated by a radiation delivery system that includes a radiation source configured to deliver the radiation beam.
    Type: Grant
    Filed: March 2, 2023
    Date of Patent: January 2, 2024
    Assignee: Sun Nuclear Corporation
    Inventors: Jeffrey M. Kapatoes, Jeffery Simon
  • Patent number: 11857804
    Abstract: A method (100) is disclosed for determining a medical imaging schedule for a subject receiving treatment at a target site. The method comprises obtaining (102) first blood panel information from a first blood sample acquired from the subject prior to the treatment commencing; obtaining (104) initial imaging data acquired in respect of the target site prior to the treatment commencing; obtaining (106) information regarding the treatment being received; and determining (108), based on at least the first blood panel information, the initial imaging data and the treatment information, a time at which to capture first imaging data in respect of the target site in order to assess a response to the treatment. A system and a computer program product are also disclosed.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: January 2, 2024
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Pedro Jorge Da Silva Rodrigues, Vanda LĂşcia de Carvalho Vitorino De Almeida, Reinhold Wimberger Friedl
  • Patent number: 11850023
    Abstract: A magnetic resonance tomography unit and a method is provided in which a patient couch may be moved in relation to the longitudinal direction into the patient tunnel in the transversal direction into a left-hand side extreme position and an opposite-lying right-hand side extreme position. Using an image acquisition facility in the left-hand side extreme position a right-hand side part is acquired and in the right-hand side extreme position a left-hand side part of the outer contour of the predetermined object is acquired. Using the image acquisition facility, the outer contour of the object is subsequently created from the left-hand side part of the outer contour and also from the right-hand side part of the outer contour.
    Type: Grant
    Filed: September 22, 2022
    Date of Patent: December 26, 2023
    Assignee: Siemens Healthcare GmbH
    Inventors: Elena Nioutsikou, Manuel Schneider, Martin Requardt
  • Patent number: 11847721
    Abstract: Much of the image processing that is applied to medical images is a form of “inverse problem”. This is a class of mathematical problems in which a “forward” model by which a signal is converted into dataset is known, to at least some degree, but where the aim is to reconstruct the signal given the resulting dataset. Thus, an inverse problem is essentially seeking to discover x given knowledge of A(x)+noise by finding an appropriate reconstruction operator A† such that A† (A(x)+noise)?x, thereby enabling us to obtain x (or a close approximation) given knowledge of an output dataset consisting of A(x)+noise. Generally, several such processes (or their equivalents) are applied to the image dataset.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: December 19, 2023
    Assignee: ELEKTA AB (PUBL)
    Inventors: Jonas Anders Adler, Ozan Ă–ktem
  • Patent number: 11844963
    Abstract: Example methods and systems for photon energy synthesis and introducing energy modulation into radiation treatment planning process and delivery process are provided. Example methods comprise obtaining, via a linear accelerator, a first photon energy beam dosimetric data, a second photon energy beam dosimetric data, and an intermediate photon energy beam dosimetric data, and fitting the first photon energy beam dosimetric data and the second photon energy beam dosimetric data according to a preset fitting coefficient. A synthesized photon beam is then generated from dosimetric data from the fitted first photon energy beam dosimetric data and the fitted second photon energy beam dosimetric data. Further, continuously variable photon energies can be derived, where two or more existing photon energy beams are combined linearly and applied to both forward and inverse radiation planning modules for a radiation treatment plan.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: December 19, 2023
    Assignee: Duke University
    Inventors: Qiuwen Wu, Bo Liu, Fugen Zhou, Xile Zhang
  • Patent number: 11844962
    Abstract: Disclosed herein are radiotherapy methods and systems that can display a workflow-oriented graphical user interface(s). In an embodiment, a method comprises presenting, by a server, a first page of a first graphical user interface on the radiotherapy console associated with a radiotherapy machine in a treatment room, wherein the first graphical user interface contains a plurality of pages, each page corresponding to a stage of treatment implemented by the radiotherapy machine, and the first page corresponds to a first stage; and transitioning, by the server, the first page of the first graphical user interface to a second page of the first graphical user interface corresponding to a second stage responsive to an input of a user interacting with a second graphical interface presented on a display in the treatment room indicating that at least a predetermined portion of tasks associated with the first stage has been satisfied.
    Type: Grant
    Filed: December 30, 2020
    Date of Patent: December 19, 2023
    Assignee: VARIAN MEDICAL SYSTEMS, INC.
    Inventors: Filip Vojan, Brian Spatola
  • Patent number: 11826560
    Abstract: A computer-implemented method for generating a radiation therapy treatment plan for a volume of a patient, the method comprising: receiving an image of the volume; receiving at least one dose-distribution-derived function configured to provide a value as an output based on, as input, at least part of a dose distribution defined relative to the image; receiving a first probability distribution and at least a second, different, probability distribution, the first and at least second probability distributions; defining a multi-criteria optimization problem comprising at least a first objective function based on the at least one dose-distribution-derived function, the first probability distribution and a loss function; and a second objective function based on the at least one dose-distribution-derived function, the second probability distribution and the loss function; and performing a multi-criteria optimization process based on the at least two objective functions to generate at least two output treatment plans
    Type: Grant
    Filed: May 19, 2021
    Date of Patent: November 28, 2023
    Assignee: Raysearch Laboratories AB (Publ)
    Inventor: Tianfang Zhang
  • Patent number: 11823778
    Abstract: An apparatus for developing an intensity-modulated radiation therapy treatment plan includes a memory that stores machine instructions and a processor that executes the machine instructions to receive a clinical goal associated with the treatment plan as a user input. The processor further executes the machine instructions to determine a plan objective based on the clinical goal, generate a cost function comprising a term based on the plan objective, and assign an initial value to a parameter associated with the term. The processor also executes the machine instructions to identify a microstate that results in a reduced value associated with the cost function, evaluate a fulfillment level associated with the clinical goal, and adjust the value of the parameter to improve the fulfillment level.
    Type: Grant
    Filed: October 13, 2021
    Date of Patent: November 21, 2023
    Assignee: SIEMENS HEALTHINEERS INTERNATIONAL AG
    Inventors: Esa Kuusela, Lauri Halko
  • Patent number: 11819711
    Abstract: Provided is a device for verifying a radiotherapy system, including at least two of a first verification phantom, a second verification phantom, and a third verification phantom, wherein a slot for holding a film is provided in the first verification phantom, a first positioning member is disposed at a center of the second verification phantom, a second positioning member is disposed at a center of the third verification phantom, and a center point of the first verification phantom, a center point of the first positioning member and a center point of the second positioning member are coaxial.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: November 21, 2023
    Assignee: OUR UNITED CORPORATION
    Inventors: Wen Wang, Hao Yan, Tianchang Gou, Jinsheng Li, Jiuliang Li, Fan Gao
  • Patent number: 11819308
    Abstract: Systems and methods for real-time target validation during radiation treatment therapy based on real-time target displacement and radiation dosimetry measurements.
    Type: Grant
    Filed: February 13, 2023
    Date of Patent: November 21, 2023
    Assignee: VARIAN MEDICAL SYSTEMS, INC.
    Inventors: John Rodenbeck Adler, Jr., Jianing Shi, James E. Clayton
  • Patent number: 11813033
    Abstract: A radiolucent circumduction joint that has one, two, or three degrees of axis move movement about a central point that is able to mirror human joint movement.
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: November 14, 2023
    Inventor: Michael Campagna
  • Patent number: 11801398
    Abstract: Described herein are methods for beam station delivery of radiation treatment, where the patient platform is moved to a series of discrete patient platform locations or beam stations that are determined during treatment planning, stopped at each of these locations while the radiation source rotates about the patient delivering radiation to the target regions that intersect the radiation beam path, and then moving to the next location after the prescribed dose of radiation (e.g., in accordance with a calculated fluence map) for that location has been delivered to the patient.
    Type: Grant
    Filed: June 2, 2022
    Date of Patent: October 31, 2023
    Assignee: RefleXion Medical, Inc.
    Inventors: Yevgen Voronenko, Jayakrishnan Janardhanan, Debashish Pal, Rostem Bassalow, Peter Demetri Olcott, Michael Kirk Owens
  • Patent number: 11801395
    Abstract: A photodynamic therapy (PDT) apparatus and method are disclosed. The PDT apparatus can include a flexible optical applicator that includes a plurality of light emitting devices for producing an irradiance pattern of therapy light to a target area of a patient. The PDT system includes an optical light controller that includes a computer processor. The method disclosed includes determining a treatment plan based on a plurality of therapy light parameters, photosensitizing drug selection, patient specific parameters, optimized light interval and other relevant parameters. The method further includes monitoring the application of the therapy light against the treatment plan and determining an updated treat plan in the event of a deviation from an initial treatment plan.
    Type: Grant
    Filed: July 28, 2021
    Date of Patent: October 31, 2023
    Assignee: Lumeda Inc.
    Inventors: Trevor MacDougall, Sanders Paul
  • Patent number: 11798674
    Abstract: A compensating device for use in ion-based radiotherapy may comprise a disk with a number of protrusions may be placed in a radiation beam to affect the ions in the beam in different ways to create an irradiation field from a broad beam. This is particularly useful in FLASH therapy because of the limited time available or modulating the beam. A method of designing such a compensating device is proposed, comprising the steps of obtaining characteristics of an actual treatment plan comprising at least one beam, determining at least one parameter characteristic of the desired energy modulation of the actual plan by performing a dose calculation of the initial plan and, based on the at least one parameter, computing a shape for each of the plurality of elongated elements to modulate the dose of the delivery beam to mimic the dose of the initial plan per beam.
    Type: Grant
    Filed: April 25, 2022
    Date of Patent: October 24, 2023
    Assignee: Raysearch Laboratories AB
    Inventors: Erik Traneus, Björn Hårdemark
  • Patent number: 11794037
    Abstract: A method for radiation therapy treatment verification includes acquiring: treatment plan information from a radiation therapy system; patient image data; and transit image data received from an electronic portal imaging device during radiation therapy. The treatment plan information is divided into a plurality of segments. Predicted segment image data is determined utilizing a predicted image calculation algorithm and at least the patient image data and the treatment plan information. A predicted integrated image is determined through superposition of the predicted segment image data. Measured segment responses are determined from the transit image data utilizing the predicted segment image data and the predicted integrated image. The measured segment responses are converted to measured segment doses. A measured dose map having a sum of the measured segment doses is compared to a planned dose map based on the treatment plan information to assess radiation treatment delivery.
    Type: Grant
    Filed: January 8, 2021
    Date of Patent: October 24, 2023
    Assignee: Sun Nuclear Corporation
    Inventors: Amir Ramezanzadeh Moghadam, Jeffrey M. Kapatoes
  • Patent number: 11786758
    Abstract: A radiation dose received by a patient from a radiation therapy system can be verified by acquiring a cine stream of image frames from an electronic portal imaging device (EPID) that is arranged to detect radiation exiting the patient during irradiation. The cine stream of EPID image frames can be processed in real-time to form exit images providing absolute dose measurements at the EPID (dose-to-water values), which is representative of the characteristics of the radiation received by the patient. Compliance with predetermined characteristics for the field can be determined during treatment by periodically comparing the absolute dose measurements with the predetermined characteristics, which can include a predicted total dose in the field after full treatment and/or a complete irradiation area outline (CIAO). The system operator can be alerted or the irradiation automatically stopped when non-compliance is detected.
    Type: Grant
    Filed: May 26, 2021
    Date of Patent: October 17, 2023
    Assignees: SIEMENS HEALTHINEERS INTERNATIONAL AG, VARIAN MEDICAL SYSTEMS, INC.
    Inventors: Christof Baltes, Todd Holmes
  • Patent number: 11786124
    Abstract: Described herein is an implantable device comprising a radiation-sensitive element (such as a transistor) configured to modulate a current as a function of radiation exposure to the transistor; and an ultrasonic device comprising an ultrasonic transducer configured to emit an ultrasonic backscatter that encodes the radiation exposure to the transistor. Further described herein is an implantable device comprising a radiation-sensitive element (such as a diode) configured to generate an electrical signal upon encountering radiation; an integrated circuit configured to receive the electrical signal and modulate a current based on the received electrical signal; and an ultrasonic transducer configured to emit an ultrasonic backscatter based on the modulated current encoding information relating to the encountered radiation.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: October 17, 2023
    Assignee: The Regents of the University of California
    Inventors: Michel M. Maharbiz, Jose M. Carmena, Mekhail Anwar, Kristofer S. J. Pister, Stefanie V. Garcia
  • Patent number: 11771920
    Abstract: Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: October 3, 2023
    Assignee: Varian Medical Systems, Inc.
    Inventors: Renate Parry, Eric Abel, Swati Girdhani, Stanley Mansfield, Patrick Kupelian, Deepak Khuntia
  • Patent number: 11759657
    Abstract: A radiation treatment device is provided. The device includes an imaging unit and a single radiotherapy unit adjacent to a second end of the imaging unit. The imaging unit includes a first opening at a first end of the imaging unit adapted to receive a patient; at least one imaging source; and at least one imager arranged opposite the imaging source. The imaging source and the imager are rotatable about the rotational axis. The radiotherapy unit includes a source body carrying radioactive sources and a collimator having collimation channels. The collimation channels permit treatment beams emitted by the radioactive sources to be projected inside the imaging unit and focused at an intersection point located within an imaging beam of the imaging unit. The source body and the collimator are arranged concentric about the rotational axis and close a second opening at the second end.
    Type: Grant
    Filed: January 27, 2021
    Date of Patent: September 19, 2023
    Assignee: OUR UNITED CORPORATION
    Inventors: Haifeng Liu, Daliang Li
  • Patent number: 11759660
    Abstract: The present disclosure relates to systems and methods for reconstructing fluence map. The system may obtain a plurality of radiation tasks based on a radiotherapy plan. Each of the plurality of radiation tasks may include a radiation field corresponding to the radiation task. For each of the plurality of radiation tasks, the system may determine whether a shape change between a radiation field corresponding to the radiation task and a radiation field corresponding to a preceding radiation task exceeds a shape change threshold. The system may determine a fluence map corresponding to the radiation task based on a first determination result of whether the shape change between the radiation field corresponding to the radiation task and the radiation field corresponding to the preceding radiation task exceeds the shape change threshold.
    Type: Grant
    Filed: October 30, 2020
    Date of Patent: September 19, 2023
    Assignee: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.
    Inventors: Huajie Han, Shiquan Zhang, Yanfang Liu
  • Patent number: 11752364
    Abstract: A cabin type beam irradiation apparatus and a method for performing beam irradiation method are provided. According to an embodiment, the beam irradiation apparatus comprises: a gantry having a hollow frame structure, the hollow portion of which being formed as a treatment cabin; a first guide rail, which is fixedly arranged on the frame; a treatment head, which is slidably arranged on the first guide rail; and an entry door, which may be openably and closably arranged on the gantry. The beam irradiation apparatus can perform radiotherapy on patients in a standing or sitting posture. Imaging guidance is additionally used to ensure the accuracy of the treatment position, and thus highly focused radiation is achieved by (non)coplanar radiotherapy. Further, the apparatus may have self-shielding function, and can reduce the difficulty and cost for construction of a machine room.
    Type: Grant
    Filed: April 8, 2021
    Date of Patent: September 12, 2023
    Inventors: Jianrong Dai, Chuanmeng Niu
  • Patent number: 11752363
    Abstract: A radiotherapy apparatus is disclosed, having an imaging system and a therapeutic radiation source, an imageable volume into which therapeutic radiation may be provided, a first imaging means for providing an image resulting from the imaging system and a second imaging means for providing an image resulting from the therapeutic radiation, and a patient support moveable relative to the volume, wherein the patient support is provided with a calibration portion comprising at least one object of a material capable of appearing in the image produced by the first imaging means and at least one object of a material capable of appearing in the image produced by the second imaging means, the at least one object being fixed in a pre-determined position relative to the calibration portion and the calibration portion being fixed in a pre-determined position relative to the patient support, the patient support being moveable so that the at least one object portion may optionally be positioned within or outside the volume.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: September 12, 2023
    Assignee: Elekta Limited
    Inventor: Julian Byrne
  • Patent number: 11748847
    Abstract: A terminal for receiving streaming data may receive information of a plurality of different quality versions of an image content; request, based on the information, a server for a version of the image content from among the plurality of different quality versions of the image content; when the requested version of the image content and artificial intelligence (AI) data corresponding to the requested version of the image content are received, determines whether to perform AI upscaling on the received version of the image content, based on the AI data; and based on a result of the determining whether to perform AI upscaling, performs AI upscaling on the received version of the image content through a upscaling deep neural network (DNN) that is trained jointly with a downscaling DNN of the server.
    Type: Grant
    Filed: July 27, 2021
    Date of Patent: September 5, 2023
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Youngo Park, Yumi Sohn, Myungjin Eom, Kwangpyo Choi
  • Patent number: 11737714
    Abstract: Cone-beam computer tomography systems, devices, and methods for image acquisition of large target volumes using partial scans.
    Type: Grant
    Filed: May 18, 2021
    Date of Patent: August 29, 2023
    Assignees: VARIAN MEDICAL SYSTEMS, INC., SIEMENS HEALTHINEERS INTERNATIONAL AG
    Inventors: David Kirk Jensen, Reto W. Filiberti, Markus Oelhafen, Aime Pascal Laurence Paysan
  • Patent number: 11738208
    Abstract: A method for radiation therapy treatment planning includes: a) defining a decision variable search space by projecting an initial seed point onto a pareto front, where the pareto front and decision variable search space are defined in the same coordinate space; b) projecting search points in the decision variable search space to the pareto front using a one-dimensional search algorithm to produce projected points on the pareto front; c) updating the search points by performing a gradient-free optimization that evaluates a treatment planning scoring function at the projected points on the pareto front; and d) repeating steps (b), (c) to search within the decision variable search space until a convergence criterion is satisfied, thereby producing a pareto optimal and clinically acceptable treatment plan.
    Type: Grant
    Filed: July 8, 2021
    Date of Patent: August 29, 2023
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Charles Huang, Lei Xing
  • Patent number: 11730977
    Abstract: The present disclosure provides systems and methods for adjusting a multi-leaf collimator (MLC) in a treatment process according to a treatment plan or a portion thereof. The MLC may include at least one closed leaf pair in the treatment process. The method may include: for each of the at least one closed leaf pair, determining an offset for the closed leaf pair; and causing the at least one closed leaf pair to move based on the determined at least one offset before or during the treatment process.
    Type: Grant
    Filed: January 23, 2020
    Date of Patent: August 22, 2023
    Assignee: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.
    Inventors: Johannes Stahl, Walter Arturo Aguilar
  • Patent number: 11735309
    Abstract: Methods and systems for evaluating a proposed treatment plan for radiation therapy, for evaluating one or more delineated regions of interest for radiation therapy, and/or for generating a proposed treatment plan for radiation therapy. Machine learning based on historical data may be used.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: August 22, 2023
    Assignee: UNIVERSITY HEALTH NETWORK
    Inventors: Thomas G. Purdie, Christopher James McIntosh, Igor Svistoun