Abstract: A method for treating electrocoating fluids involves exposing the electrocoating fluid to high-frequency ultrasound while emitting microbubbles into the electrocoating fluid. In further embodiments, the method includes emitting electromagnetic radiation into the fluid. In other embodiment, the method includes routing electrocoating fluid into a compartment. An apparatus for treating electrocoating fluids comprises a compartment (2) configured to hold electrocoating fluid, at least one ultrasound emitter (1) configured to emit high-frequency ultrasound (4) into the compartment (2), and a microbubble emitter (3) configured to emit microbubbles (5) into the compartment (2). In further embodiments, the apparatus may be in fluid communication with an external electrocoating bath. In other embodiments, the apparatus may include an electromagnetic radiation emitter (12), which may emit visible light into the compartment.

Abstract: Devices and methods for treating, preventing from growth, and neutralizing hyperproliferative, undifferentiated, or virally infected cells in a liquid medium using high-frequency, low-energy ultrasound.

Abstract: This invention relates to compositions and methods for preventing oxidation of beneficial agents.

Abstract: The invention describes a device and a method for cleaning an oscillatable membrane (3) of a membrane aerosol generator (4) of an inhalation therapy device, in which a cleaning liquid is supplied to the membrane (3) on the aerosol side, and the membrane (3) is caused to oscillate in such a manner that the cleaning liquid is conveyed through the openings of the membrane (3) to the liquid side of said membrane.

Abstract: An acoustic system for applying vibratory energy including a horn connected to an ultrasonic energy source. The horn defines an overall length and wavelength, and at least a leading section thereof is comprised of a ceramic material. The leading section has a length of at least ? the horn wavelength. In one preferred embodiment, an entirety of the horn is a ceramic material, and is mounted to a separate component, such as a waveguide, via an interference fit. Regardless, by utilizing a ceramic material for at least a significant portion of the horn, the ultrasonic system of the present invention facilitates long-term operation in extreme environments such as high temperature and/or corrosive fluid mediums. The present invention is useful for fabrication of metal matrix composite wires.

Abstract: A device for treating liquid medium has an ultrasound emitter located relative to a compartment of a container holding a liquid medium and a microbubble emitter located relative to the compartment. The ultrasound emitter emits high-frequency ultrasound between about 200 KHz and 10 MHz. The microbubble emitter emits bubbles with an average diameter of less than 1 mm.

Abstract: Methods of fixing and processing tissue and samples on a membrane by using ultrasound radiation as a part of the method are presented. Ultrasound of a frequency in the range of 0.1-50 MHz is used and the sample or tissue receives 0.1-200 W/cm2 of ultrasound intensity. The use of ultrasound allows much shorter times in the methods. Also presented are apparati comprising transducers of one or of multiple heads for producing the ultrasound radiation and further comprising a central processing unit and optionally comprising one or more sensors. Sensors can include those to measure and monitor ultrasound and temperature. This monitoring system allows one to achieve accurate and optimum tissue fixation and processing without overfixation and tissue damage. The system also allows the performance of antigen-antibody reactions or nucleic acid hybridizations to be completed in a very short time while being highly specific and with a very low or no background.

Abstract: Methods and compositions for modifying a substrate surface are provided. In accordance with the subject methods, a substrate surface is contacted with a particulate-containing fluid. The fluid is then ultrasonically or sonically agitated to modify the substrate surface. In certain embodiments, the particulate-containing fluid has a pH above the isoelectric point of the substrate. Also provided are devices capable of providing ultrasonic and/or sonic energy and which include a non-acidic, particulate-containing fluid. The subject invention also provides systems and kits for use in practicing the subject methods.

Abstract: A system for treating meat by the application of a shock wave to the meat while the meat is in contact with a diaphragm which is substantially transparent to the shockwave, confines the meat within a tunnel. In addition, the diaphragm and shock wave generating chamber are preferably disposed above the meat.

Abstract: Apparatus for treating allografts, having a sonication tank configured to transmit ultrasonic energy to the interior of the tank; a treatment canister rotatably positioned in said sonication tank, and configured to receive allografts therein; and a treatment fluid source in fluid communication with said treatment canister. Methods of treating allografts and methods for determining microbial contamination using the apparatus.

Abstract: The present invention relates to a microfluidic system for processing a cell-containing liquid. The system includes a lysing zone to receive the cell-containing sample and a positioning element to position the cell-containing sample in a lysing position in the vicinity of a lysing mechanism. The lysing mechanism releases intracellular material, such as DNA or RNA, from the cells. In one embodiment, the lysing mechanism includes electrodes for generating an electric field sufficient to release intracellular contents from the cells. Alternatively, the lysing mechanism may lyse the cells using chemical, heat and/or ultrasonic techniques or any combination of these techniques.

Abstract: A device (1) for preventing the growth of the bacteria or removing the bacteria bred on the inner wall surfaces of the ducts (8, 9, 10) of a dental unit, comprising a transponder (3) having a control unit (2) generating electric signals including audible frequency components, a coil (3a), and a case (3b) for storing the coil (3a) and mounting means (5) for mounting the transponder (3) on the outer wall surface of the duct (8), whereby an audible frequency electric signal allowed to transmit through the ducts (8, 9, 10) is generated by applying the electric signals to the coil (3a).

Abstract: Methods of fixing and processing tissue and samples on a membrane by using ultrasound radiation as a part of the method are presented. Ultrasound of a frequency in the range of 0.1–50 MHz is used and the sample or tissue receives 0.1–200 W/cm2 of ultrasound intensity. The use of ultrasound allows much shorter times in the methods. Also presented are apparati comprising transducers of one or of multiple heads for producing the ultrasound radiation and further comprising a central processing unit and optionally comprising one or more sensors. Sensors can include those to measure and monitor ultrasound and temperature. This monitoring system allows one to achieve accurate and optimum tissue fixation and processing without overfixation and tissue damage. The system also allows the performance of antigen-antibody reactions or nucleic acid hybridizations to be completed in a very short time while being highly specific and with a very low or no background.

Abstract: The present invention relates to a device for the extracorporeal treatment of blood or plasma, comprising two compartments, one compartment intended for circulating blood or plasma, and one compartment intended for circulating spent liquid, separated by a wet semi-permeable membrane, characterized in that the device has, before and after sterilization, the following technical characteristics: the membrane is impregnated with an aqueous glycerol solution; the aqueous glycerol solution contains from 7% to 15% by weight of glycerol and is free of toxic chemical compounds; the two compartments are purged of the aqueous glycerol solution. The present invention also relates to processes for manufacturing this device.

Abstract: Devices and methods for treating, preventing from growth, and neutralizing microorganisms in cutting fluids using high-frequency, low-energy ultrasound.

Abstract: Embodiments of the invention provide a water treatment method and water treatment device capable of automatically tracking the frequency of ultrasonic waves and automatically controlling their amplitude such that optimal cavitation is generated. In one embodiment, a water treatment method of sterilizing water containing microbes comprises supplying ultrasonic vibration to the water to be treated by driving and controlling a transducer of a sterilization cell using a signal; detecting an amplitude of the transducer and a frequency of the signal applied to the transducer; and controlling the amplitude and a vibration frequency of the transducer to target values in accordance with the detected transducer amplitude and the detected signal frequency.

Abstract: An assay apparatus includes a cell with a working electrode and a sonicating device structurally coupled to the cell for sonication the contents of the cell.

Abstract: According to the present invention, a pre-cleaning process is performed for removing a physical substance such as blood, mucus or tiny pieces of tissue that are attached to the exterior of the medical device and are inside a duct or a hollow portion. Then, the pre-cleaned medical device is immersed in a chlorine dioxide solution and/or a chlorine dioxide solution is passed through the duct or the hollow portion. Thereafter, the medical device is placed in a chlorine dioxide gas atmosphere and/or a chlorine dioxide gas is passed through the duct or the hollow portion. In this manner, the exterior of the medical device and the interiors of the duct and the hollow portion are deodorized, disinfected and sterilized.

Abstract: A medical capsule is taken into the human body to collect biomedical information about the human body. When the medical capsule is discharged from within the human body, a medical capsule retrieval device detects the medical capsule using a magnet or a sensor, and catches the medical capsule with a net.

Abstract: An apparatus for the ultrasonic destruction of microbiological contamination of fluids. The process involves subjecting contaminated fluids to ultrasonic vibration so as to cause cavitation within the fluids. The cavitation results in the destruction of microbial cells and mats of microbial colonies. To create cavitation in the fluids a number of piezoelectric ceramic rings surround a metal tube through which the fluids flows. Those piezoelectric rings are immersed in a transmission medium which is pressurized sufficiently to prevent cavitation occurring in it and causing damage to the piezoelectric rings electrodes. This process is applicable to many liquids such as fuels, lubricating fluids, potable and marine ballast waters, dairy products, pharmaceuticals, liquid food products and beverages.

Abstract: An ultrasonic energy source is used to provide a variable force for measuring the binding forces between molecular entities and for sensing the presence of an analyte in a test sample. The device includes a surface that has a first binding member attached thereto and one or more particles that have a second binding member attached thereto. A reaction vessel is provided for exposing the surface to the particles whereby, if the first binding member has a binding affinity for the second binding member, a complex is formed between individual first binding members and individual second binding members and the particles thereby become immobilized with respect to the surface. The ultrasonic energy source is positioned for applying a variable ultrasonic force onto the surface, and the position of the particles is monitored as the intensity of the ultrasonic force is varied.

Abstract: A method is provided for protecting a medical instrument and other articles adapted to be inserted into and removed for re-use from a human or animal body. A temporary coating of an oxidation-resistant material is applied to the instrument or part thereof to protect the instrument or part thereof over at least one sterilizing or disinfecting cycle.

Abstract: A method and an apparatus in form of a disinfecting apparatus comprising a steam device for combatting germs on the surface of products, in particular of food products. The apparatus employs a combination of steam and ultrasound to kill germs on the surface of a product which is conveyed past the steam device. Pressurized steam is fed through a steam passage to an opening conveying the steam to a cavity, in which the steam is made to oscillate at a ultrasonic frequency. The oscillations in the steam prevent the steam from heating the products excessively, while germs presents on the surface of the products are heated and killed.

Abstract: A device for treating liquid medium has an ultrasound emitter located relative to a compartment of a container holding a liquid medium and a microbubble emitter located relative to the compartment. The ultrasound emitter emits high-frequency ultrasound between about 200 KHz and 10 MHz. The microbubble emitter emits bubbles with an average diameter of less than 1 mm.

Abstract: A method and apparatus (10) for treating a fluid or materials therein with acoustic energy has a vessel (14) for receiving the fluid with inner walls shaped to focus acoustic energy to a target zone within the vessel. One or more nozzles (26) are directed into the vessel (14) for injecting a condensable vapor, such as steam, into the vessel (14). The system may include a steam source (18) for providing steam as the condensable vapor from an industrial waste heat source. Steam drums (88) are disposed between the steam source (18) and nozzles (26) to equalize and distribute the vapor pressure. A cooling source (30) provides a secondary fluid for maintaining the liquid in the vessel (14) in subcooled conditions. A heating jacket (32) surrounds the vessel (14) to heat the walls of the vessel (14) and prevent biological growth thereon. A pressurizer (33) may operate the system at elevated pressures.

Abstract: A new, novel and useful disinfection and purification system comprised of organic compounds in synergistic action with selected metal ions and method of manufacture and use. One of the benefits that is derived from this system is the ability to quickly and easily treat a surface, fluid or medium for disinfection of bacteria, fungi, viruses, algae and protozoans, with a non-toxic, non-chlorinated mixture that effectively kills all such organisms in minutes or hours. The disinfection and purification system remains effective for long periods of time maintaining its disinfection capacity making it highly effective for stored or transported mediums such as potable drinking water. The disinfection and purification system may be incorporated with carbon block or membrane filters to disinfect filtered liquids such as water to render it potable.

Abstract: Apparatus and method for sterilization of liquid includes a liquid container containing a liquid and having a piezoceramic ring that is connected to a power supply system. Power supply system supplies electric signals to the piezoceramic ring that are transformed into mechanical waves and cause vibrations in the liquid.

Abstract: A method for producing a cleaned bone graft with osteoinductivity above 2.0 suitable for transplantation into a human. The first step is sonicating a bone graft in a nonionic detergent in an ultrasonic cleaner at a temperature ranging from about 33° C. to about 37° C. and for a time period ranging from 15 minutes to 2 hours effective to produce a cleaned bone graft essentially free from bone marrow. The bone graft is sonicated in purified water in an ultrasonic cleaner at a temperature ranging from about 33° C. to about 37° C. a plurality of times to remove the detergent producing a cleaned bone graft. The bone graft is then sonicated in hydrogen peroxide in an ultrasonic cleaner at a temperature ranging from about 33° C. to about 37° C. for a time period ranging from 10 minutes to about 2 hours effective to retain osteoinductivity of the bone graft and again sonicated in purified water in an ultrasonic cleaner at a temperature ranging from about 33° C. to about 37° C.

Abstract: A method for destroying bacterial spores, germs, and the like is disclosed, comprised of a non-contact ultrasound device that produces ultrasonic beams transferred in ambient air without the use of a liquid medium in frequencies ranging between 50 kHz to 5 MHz. The method of the present invention can be used as a germicide for destroying anthrax spores and other highly toxic microbes that may be used as an agent of bioterrorism.

Abstract: An apparatus including at least one sonotrode (2) designed to generate ultrasound of variable power in at least one biological sample (5) containing cells to be lysed, the sample (5) being contained in at least one receptacle (4 or 10) such that the sonotrode (2) is in direct contact with the receptacle(s) (4). Also disclosed is a method for using ultrasound to lyse a biological sample (5) contained in a receptacle (4), which includes placing the receptacle (4) in direct contact with the sonotrode (2), and activating the sonotrode (2) for long enough to lyse the cells in the sample (5) but preserve the DNA and/or RNA molecules released for subsequent operations, e.g. amplification. The invention is particularly applicable in the discipline of molecular biology.

Abstract: A device containing a light source, a sample support and a temperature control compartment. The sample support is positioned to support multiple sample vessels for irradiation by the light source. The temperature control compartment maintains the temperature of the sample vessels within a desired range. The light source, sample support and temperature control compartment are all contained within an opaque housing.

Abstract: Active acoustic piping that allows treatment of material flowing in a piping system is disclosed. Treatment of waste water and other fluids is enabled, where acoustic radiation operates on the flow material. An inner pipe has a plurality of transducer elements disposed on its external perimeter. A buffer zone around the transducer elements provides an acoustic impedance mismatch, which concentrates the acoustic energy into the flow material traveling in the inner pipe. Processes such as decontamination, flow unclogging, fluid and particulate mixing, particulate size reduction, and particulate separation are enabled. No pressure compensation scheme is required.

Abstract: The present invention concerns methods, compositions and apparatus for neutralizing bioagents, wherein bioagents comprise biowarfare agents, biohazardous agents, biological agents and/or infectious agents. The methods comprise exposing the bioagent to an organic semiconductor and exposing the bioagent and organic semiconductor to a source of energy. Although any source of energy is contemplated, in some embodiments the energy comprises visible light, ultraviolet, infrared, radiofrequency, microwave, laser radiation, pulsed corona discharge or electron beam radiation. Exemplary organic semiconductors include DAT and DALM. In certain embodiments, the organic semiconductor may be attached to one or more binding moieties, such as an antibody, antibody fragment, or nucleic acid ligand. Preferably, the binding moiety has a binding affinity for one or more bioagents to be neutralized. Other embodiments concern an apparatus comprising an organic semiconductor and an energy source.

Abstract: An apparatus and water treatment method uses Sonically Induced Dissociative Reactions (SIDR) and Multi-bubble Sonoluminescence (MBSL) to facilitate Sonically Bounds State Oxidation (SBSO) within a SIDR chamber. Included within the SIDR chamber is counter-flow ultrasonic radiation and an optional binding agent.

Abstract: Methods are disclosed for sterilizing tissue to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria, (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, spores, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing one or more tissues with irradiation.

Abstract: The invention relates to a method using vibration for conditioning, air-conditioning, cooling and decontaminating, disinfecting and sterilizing physical media. The method is characterized in that it comprises at least one first periodic action (13) that is performed on the regulated incoming current of the physical medium (2) represented by refrigerating agents and at least one second periodic action (11) that is performed on the same physical medium in a refrigerating chamber. In this way, the flow of the physical medium (2) is formed and the necessary and adequate conditions for cooling the same are created. At least one refrigerating medium (3) and at least cold-absorbing medium (6) are caused to interact in a heat exchanging system (1). The invention also comprises at least one third periodic action (10) which is performed on a cold-absorbing medium.

Abstract: A method of sterilizing liquid is performed by providing a vibrationally stirring apparatus having a vibration generating unit containing a vibration motor (14), a vibrating rod (7) operationally connected to the vibration generating unit, vibration vanes (10) fixed to the vibrating rod, and vibration vane fixing members (9) for fixing the vibration vanes to the vibrating rod, wherein the vibration vane (10) has a surface made of sterilizing metal and the vibration vane fixing member (9) is made of magnetic field generating material; submerging the vibration vanes and the vibration vane fixing members in the liquid (LIQ) taken in a treatment tank (13); and vibrating the vibration vane at an amplitude of 0.1 to 15.0 mm and at a vibrational frequency of 200 to 1000 times per minute by the vibration generating unit to cause vibrationally stirring of the liquid, thereby sterilizing the liquid.

Abstract: The invention relates to a method of disinfection comprising the steps of sonicating a liquid disinfectant at a frequency selected to be above 15 MHz, preferably above 2 MHz in a nebulizing chamber to produce a nebulized disinfectant product. The frequency of the ultrasonic energy and the formulation of the disinfectant to which the ultrasonic energy is applied is such that 90% of microdroplets are between 0.8 and 2.0 micrometres in diameter. In preferred embodiments, the microdroplets are activated by the ultrasound and are substantially more effective than non-sonicated disinfectant. The invention also relates to compositions suitable for use in such methods which mar include activatable agents, surfactarits and/or agents to assist in drying.

Abstract: A humidifier meters water into a chamber in which it is subjected to ultraviolet light for a predetermined period of time sufficient to destroy microorganisms whereupon the static quantity of water is transferred to a water dispersing unit which discharges the decontaminated water in a finely divided form into the environment.

Abstract: Various forms of apparatus and methods for pretreating and sterilizing a lumen with a peroxide solution prior to sterilization of the interior of the lumen by exposing the lumen to reduced pressure and, optionally, plasma in a sterilization chamber. The pretreatment is preferably done before placing the lumen in the sterilization chamber. The method also includes exposure of the exterior of the lumen to peroxide vapor to sterilize the exterior of the lumen. Pretreatment of the interior of the lumen with liquid peroxide greatly improves the efficiency of sterilization of the interior. Exposure of the lumen to plasma reduces the time required for sterilization.

Abstract: A method for sanitizing a food processing environment includes the preparation of an aqueous ozone was solution for use in sanitizing food contact surfaces and food processing work stations. During preparation of an ozone wash solution, ozone off-gas is collected from the aqueous ozone solution. The ozone off-gas is then introduced into an ambient of the food processing environment. The introduction of the ozone off-gas can be carried out in conjunction with the application of the ozone wash solution to food contact surfaces. Additionally, the ozone off-gas can be introduced at relatively high concentrations for application to food processing equipment and food contact surfaces or, alternatively, the ozone off-gas can be diluted to relatively low levels for introduction into the ambient air of a food processing facility.

Abstract: A method and apparatus for sterilizing organic or inorganic matter through simultaneous exposure to ultraviolet light energy and ultrasonic wave energy in a non-aqueous environment such as air. The method is suitable for use in a chamber or in a mass production assembly line setting. Purification of air is similarly accomplished using simultaneous exposure to ultraviolet light and ultrasonic energy waves.

Abstract: An ultrasonic cleaner has a handle having a proximal end, a distal end, a hollow interior, and an exterior gripping surface. A brush mounting point is positioned at the proximal end of the handle and an ultrasonic vibrator is positioned within the hollow interior and operably attached to the brush mounting point. A battery is operably positioned within the hollow interior of the handle for providing power to the ultrasonic vibrator. A skin cleaning brush is mounted on the brush mounting point. The invention includes a method of cleaning skin using an ultrasonic cleaner. Ultrasonic vibration is transmitted from the ultrasonic vibrator, through the brush mounting point, to a plurality of brush bristles of the skin cleaning brush, and the skin cleaning brush is used to scrub the skin. In this arrangement, the plurality of brush bristles effectively transmit the ultrasonic vibration to the skin and work in conjunction with the liquid cleaning solvent to clean the skin.

Abstract: A method of sterilizing a tattooing solution through irradiation. Specifically, a tattooing solution such as an india ink solution is supplied and irradiated to facilitate sterilization. The radiation is, for example, gamma radiation.

Abstract: The present invention relates to a method for disinfecting and purifying liquids and gasses comprising; a) passing said liquids or gasses through a reactor or a combination of reactors, having a truncated compounded concentrator geometry; and b) simultaneously delivering and concentrating diversified electromagnetic and acoustic energies into a specific predetermined inner space of said compounded concentrator reactor, forming a high energy density zone in said reactor or reactors over a predetermined period of time. The reactor according to the present invention is preferably a compounded parabolic concentrator or a compounded ellipsoidal concentrator. The electromagnetic energy delivered and concentrated into and inside the reactor can be of any range of the electromagnetic spectrum, such as ultra-violet, visible, infra-red, microwave etc., or combination thereof. The acoustic energy is of any suitable frequency.

Abstract: A device for treating liquid medium has an ultrasound emitter located relative to a compartment of a container holding a liquid medium and a microbubble emitter located relative to the compartment. The ultrasound emitter emits high-frequency ultrasound between about 200 KHz and 10 MHz. The microbubble emitter emits bubbles with an average diameter of less than 1 mm.

Abstract: The surface of items which are penetratable for high-frequency energy, like for instance plastic food packagings which are manufactured by blow molding or vacuum molding, and in particular returnable bottles for soft drinks, are sterilized by providing a liquid film on the items, following which they are subjected to microwaves or high-frequency to heat the liquid film, preferably to the boiling point. The liquid is preferably water with a de-tensioning agent. An apparatus for performing the method is provided with wetting means, dripping off means adapted to leave a liquid film on the items during the dripping off, and heating means. The dripping off means are substantially constituted by transport means for conveying the items from the wetting means to the heating means. A system for sterilizing plastic bottles may compromise a washing section, a rinsing section, transport means adapted to let the bottles drip off during transport, and a heating section.

Abstract: A sterilization cassette and a sterilization method for sterilizing, storing, and dispensing dental instruments. The sterilization cassette includes a mounting bar and a locking bar for dental pliers of various types, a removable instrument tray, and a case with a front side which opens and hinges in two places, allowing the cassette to be arranged in horizontal and vertical configurations.

Abstract: A portable dental system and method is disclosed for cleaning endodontic files and the like during a operation such as a root canal procedure. This allows a dentist to clean files in situ while performing the removal of root material. As the file is withdrawn from the patients mouth by the dentist, it can be inserted into a sealed container through the lid and can be cleaned ultrasonically and immediately withdrawn and reinserted into a patients tooth canal for further removal of tooth and root material. Debridement of the files ensures less likelihood the file will break within the canal; furthermore, since no passing off to or cleaning the tip by an assistant is required, there is less likelihood of inadvertent skin puncturing and infection of the dentist or assistant. The sealed disposable container housing a cleaning fluid is insertably removable from the base, which supports it and provides a source of ultrasonic energy thereto.

Abstract: A system for reducing biological organisms in a liquid effluent to non-viable organic molecules that includes: a stunning chamber that applies a voltage potential across biological organisms to break cell membranes and disable the defense mechanisms of vital organisms to ultraviolet radiation; a cavitation chamber to physically destroy any remaining membranes of biologicals in the effluent that may play host to vital organisms or allow such to hide therein, the action of the stunning and cavitation chambers releasing interferons; and a molecularly implanted stimulated emitter (MISE) chamber in which high levels of ultraviolet radiation are applied to virions and spores that remain at frequencies that are readily absorbed and operate to disassociate any viable DNA and RNA strands remaining, to thereby cause “death”. Prior to the stunning chamber, preferably the effluent has any large solids therein, settled, floated or filtered out.