Abstract: A conventional cooker or retort for heat processing sealed containers, such as sealed pouches, jars or cans, has an evaporator associated therewith. A source of water is coupled to the evaporator through a valve and a source of a liquid having a higher vapor pressure than water, such as ethyl alcohol, is connected to the evaporator through a metering pump. Pressure and temperature within the retort are monitored and signals indicative thereof are connected to controllers for metering the heat supplied to the evaporator and for metering the ethyl alcohol and water delivered to the evaporator. One controller is configured to operate so that as pressure rises, proportions of ethyl alcohol introduced into the evaporator is reduced while the proportion of water introduced is increased. Another controller functions to restrict the amount of heating medium, such as steam, delivered to the evaporator as the retort temperature increases.

Abstract: Method and apparatus for sterilizing medical devices and the like. The apparatus comprises means for the recirculation of a sterilant gas and a diluting gas through narrow passages in the medical device in sufficient quantity and for sufficient time to sterilize bacteriologically, and then to aerate, exposed passage surfaces. The method comprises the circulation of a sterilant gas through a contaminated device bacteriologically to sterilize exposed surfaces, and thereafter to remove the sterilant gas by purging with sterile air or other inert gas.

Abstract: Indicators for the steam-formaldehyde sterilization process are provided which undergo a color change when placed in a steam-formaldehyde environment.

Abstract: Biocidal gas sterilization methods and apparatus are disclosed in which goods are heated and moisturized prior to addition of the sterilizing gas utilizing repressurization after initial evacuation to provide drive power for the conditioning vapor and improve conditioning efficiency. After initial evacuation to a selected subatmospheric pressure level, the chamber is repressurized with a conditioning vapor comprising steam to a subatmospheric pressure level corresponding approximately to desired sterilizing temperature, then the chamber is held with evacuating and vapor injecting interrupted for a predetermined interval; this sequence of steps is repeated a selected number of times; and, conditioning to various sterilizing temperatures is available. Initial evacuation can be accompanied by intermittent injection of conditioning vapor. No chamber measurement of temperature or relative humidity is required for conditioning control and conditioning vapor injection is free of flow rate control requirements.

Abstract: A low temperature method for the cleaning and disinfection of heat- and liquid-sensitive articles that are brought into physical contact with patients during diagnostic evaluation, surgery or therapy. These articles, such as endoscopes, bronchoscopes and related equipment are thus subject to contamination by microorganic pathogens and consequently may serve as transmittal agents for noscomial infection. In the method of this invention, quick, penetrating and adequate disinfection can be obtained by the use of a vapor consisting essentially of from 40 to 100% isopropanol and the remainder consisting predominantly of water vapor. The aforesaid articles are brought into direct contact and totally enveloping contact with the vapor at a temperature between 45.degree. C. and 65.degree. C. for a period effective to destroy the pathogens.When the articles are then removed from vapor contact, any condensed isopropanol on the surfaces of the article quickly evaporates.

Abstract: Sterilizing apparatus and control arrangement providing for selective operation of a plurality of differing types of sterilizing units including sterilizers capable of carrying out a plurality of differing steam and/or gas sterilizing cycles are disclosed. An electronic microcomputer controller is provided on a plurality of circuit boards, at least one of which is an integrated complete controller for at least one type of sterilizer; expander circuit boards extend control to remaining differing types of sterilizers. Also, provision is made for automatically identifying each differing type of sterilizer upon interconnecting an integrated control system with a selected sterilizer.

Abstract: A system for producing a stream of humidified sterilizing gas for sterilizing objects such as the water systems of space vehicles and the like. The system includes a source of sterilant gas which is fed to a mixing chamber having inlet and outlet ports. Water is carried in the mixing chamber with the level of the water only partially filling said mixing chamber so as to provide an empty space adjacent the top of the chamber. A heater is provided for heating the water in said chamber producing a humidified atmosphere. The sterilant gas is fed through an arcuate shaped tubular member connected to the inlet port of the mixing chamber for producing a vortex type of flow of sterilant gas into the chamber for being humidified. A tubular member extends from the mixing chamber for supplying the humidified sterilant gas to the object for being sterilized. Scrubbers are provided for removing the sterilant gas after use.

Abstract: Biocidal gas sterilization methods and apparatus are disclosed in which goods are heated and moisturized prior to addition of the sterilizing gas utilizing repressurization after initial evacuation to provide drive power for the conditioning vapor and improve conditioning efficiency. After initial evacuation to a selected subatmospheric pressure level, the chamber is repressurized with a conditioning vapor comprising steam to a subatmospheric pressure level corresponding approximately to desired sterilizing temperature, then the chamber is held with evacuating and vapor injecting interrupted for a predetermined interval; this sequence of steps is repeated a selected number of times; and, conditioning to various sterilizing temperatures is available. Initial evacuation can be accompanied by intermittent injection of conditioning vapor. No chamber measurement of temperature or relative humidity is required for conditioning control and conditioning vapor injection is free of flow rate control requirements.

Abstract: Conditioning of goods for subsequent sterilization with a biocidal agent in a sealable chamber includes removal of air, and moistening and heating the goods to the desired temperature levels. Controlled evacuation of the chamber and coordinated admission of conditioning vapor into the chamber provides cyclic variations in chamber pressure between preselected subatmospheric pressures to subject goods in the chamber to a plurality of cyclic subatmospheric pressure pulses. The time required for the cyclic pressure variations is responsive to load characteristics, including heat and moisture absorption characteristics of the goods being conditioned, and is independent of prescribed times or direct measurement of load temperature. The subatmospheric pressure levels are selected based on the temperature-pressure relationship of the conditioning vapor so that chamber temperature during cyclic pulsing does not exceed the desired sterilization temperature.

Abstract: A "cold" gas sterilization process that operates at temperatures below 80.degree. C. in a temperature range that is generally considered nonsporicidal. The process is capable of sterilizing with gaseous hydrogen peroxide at extremely low concentrations in a gas phase, such as 0.5 mg/L. The widely used process of "cold" sterilizing with ethylene oxide is typically run at a gas concentration of 630 mg/L and 55.degree. C. Apparatus is also disclosed for use of this process in "cold" sterilization of contact lenses.

Abstract: Conditioning of goods for subsequent sterilization with a biocidal agent in a sealable chamber includes removal of air, and moistening and heating the goods to the desired temperature levels. Controlled evacuation of the chamber and coordinated admission of conditioning vapor into the chamber provides cyclic variations in chamber pressure between preselected subatmospheric pressures to subject goods in the chamber to a plurality of cyclic subatmospheric pressure pulses. The time required for the cyclic pressure variations is responsive to load characteristics, including heat and moisture absorption characteristics of the goods being conditioned, and is independent of prescribed times or direct measurement of load temperature. The subatmospheric pressure levels are selected based on the temperature-pressure relationship of the conditioning vapor so that chamber temperature during cyclic pulsing does not exceed the desired sterilization temperature.