Structured Visual Or Optical Indicator, Per Se Patents (Class 422/400)
-
Patent number: 11974035Abstract: Trains that pass through an inspection portal must be analyzed for structural integrity through the capture of high-resolution images of the train, the train cars and the associated parts of the train car (hoses, knuckles and wheels for example). A directed source of light using the correct camera placement and lighting for the cameras is provided to ensure that the images are the highest resolution possible with the environmental factors that are present. With the clear images that are provided the images are formed to provide an analysis of the integrity of the train.Type: GrantFiled: October 19, 2022Date of Patent: April 30, 2024Inventor: Ned Buschelman
-
Patent number: 11964237Abstract: A molecular filtration device and method of use capable of filtering and purifying molecules of a particular characteristic, wherein the amount of molecule to be filtered may be in the nanogram range and may be dispersed in a relatively large volume of solution. The resultant elution may include a relatively high concentration of desired molecule, due to a relatively small volume.Type: GrantFiled: March 11, 2022Date of Patent: April 23, 2024Assignee: Integrated Protein Technologies, Inc.Inventors: Philip D. Compton, Jared Drader
-
Patent number: 11967410Abstract: Methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. Also, algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.Type: GrantFiled: February 22, 2018Date of Patent: April 23, 2024Assignees: Meso Scale Technologies, LLC, THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.Inventors: William F Blakely, Eli N. Glezer, John Kenten, Sudeep Kumar, Anu Mathew, Natalia I. Ossetrova, George Sigal
-
Patent number: 11953494Abstract: A nanopore-based sequencing system includes a plurality of nanopore-based sequencing chips. Each of the nanopore-based sequencing chips comprises a plurality of nanopore sensors. The system comprises at least one flow cell coupled to at least one of the plurality of nanopore-based sequencing chips, wherein the flow cell coupled to the at least one of the plurality of nanopore-based sequencing chips comprises one or more fluidic flow channels that allow a fluid external to the system to flow on top of the nanopore-based sequencing chip and out of the system. The system further comprises a printed circuit board electrically connected to the plurality of nanopore-based sequencing chips.Type: GrantFiled: December 6, 2021Date of Patent: April 9, 2024Assignee: Roche Sequencing Solutions, Inc.Inventors: Yuri Mitnick, Xu Ouyang, Janusz B. Wojtowicz
-
Patent number: 11933746Abstract: A device to host a crystallization medium, such as a solution, for crystal growth and a system for X-ray diffraction experiments to determine the atomic structure of crystals. A plurality of cells have a well, a sample holder placed in the well. The solution is hosted in the sample holder between thin-plates or one thin-plate. A cap seals an opening to the cell and each sample holder can be extracted independently from each well. A system for automated X-ray diffraction experiments for small crystals in the sample holder extracted from the wells utilizes an ultrasonic acoustic levitator to determine the crystal structure at atomic resolution. X-ray diffraction images are generated by scanning the X-ray beam over the levitated sample holder along a spiral trajectory by rotating the sample holder and moving in the direction perpendicular to the X-ray beam and the rotation axis at the same time.Type: GrantFiled: November 16, 2020Date of Patent: March 19, 2024Assignee: Paul Scherrer InstitutInventors: Soichiro Tsujino, Takashi Tomizaki, Michal Kepa
-
Patent number: 11933701Abstract: Devices and methods for analyzing a sample are disclosed. In various embodiments, the present disclosure provides devices and methods for preparing a serial dilution of a sample. In various embodiments, the present disclosure provides devices and methods for preparing a serial dilution of a sample and conducting sample analysis. In various embodiments, the present disclosure provides a cartridge device and a reader instrument device. The reader instrument device receives, operates, and/or actuates the cartridge device to prepare a serial dilution of a sample and conduct sample analysis.Type: GrantFiled: April 29, 2023Date of Patent: March 19, 2024Assignee: CytoChip Inc.Inventors: Wendian Shi, Yuan Gao, Yuzhe Ding
-
Patent number: 11925933Abstract: The present invention generally relates to microfluidic devices. In some aspects, various entities, such as droplets or particles, may be contained within a microfluidic device, e.g., within collection chambers or other locations within the device. In some cases, the entities may be released from such locations, e.g., in a sequential pattern, or an arbitrary pattern. In some cases, the entities may be imaged, reacted, analyzed, etc. while contained within the collection chambers. Other aspects are generally directed to methods of making or using such devices, kits involving such devices, or the like.Type: GrantFiled: April 14, 2017Date of Patent: March 12, 2024Assignee: President and Fellows of Harvard CollegeInventors: David A. Weitz, Kiryakos S. Mutafopulos, Thomas Hufnagel
-
Patent number: 11906514Abstract: The invention encompasses methods and test strips for detecting the presence of cerebrospinal fluid (CSF) in a biological sample with a lateral flow device which uses lectin conjugates, anti-antigen conjugates, an immobilized serum line, and an immobilized anti-antigen line.Type: GrantFiled: June 8, 2022Date of Patent: February 20, 2024Assignees: NSPC Technologies, LLC, Gwangju Institute of Science and TechnologyInventor: Min-Gon Kim
-
Patent number: 11905504Abstract: A body cube for culturing tissue that includes: an organ chip holder; and a body barrier chip and a first body organ chip disposed in the organ chip holder, the first body organ chip including a first cell culture chamber that receives cell culture medium and produces a first tissue in the first cell culture chamber, such that the organ chip holder receives cell culture medium and communicates the cell culture medium to the first cell culture chamber of the first body organ chip in response to rotation of the organ chip holder.Type: GrantFiled: April 19, 2021Date of Patent: February 20, 2024Assignee: GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCEInventors: Mandy Brigitte Esch, Longyi Chen
-
Patent number: 11892393Abstract: A system and method for treating water containing at least one contaminant. The system and method include a water treatment module such as a reverse osmosis unit. An electrochemical contaminant detection system is positioned in the waste water stream of the water treatment module. The contaminant detection system includes a contaminant sensor and a water quality sensor module. The contaminant sensor measures the concentration of the contaminant in the waste water stream and the water quality sensor module measures one or more water quality parameters of the waste water stream. A processor uses an algorithm to determine the concentration of the contaminant in the feed water based on the measurements of the contaminant sensor and water quality sensor module.Type: GrantFiled: October 26, 2020Date of Patent: February 6, 2024Assignee: A.O. Smith CorporationInventor: Gusphyl Antonio Justin
-
Patent number: 11865542Abstract: A system and method, wherein the system includes: an array of wells defined at a substrate, each well including an open surface and a well cavity and a fluid delivery module including a fluid pathway through which fluid flow is controlled along a fluid path in a direction parallel to the broad face of the substrate; and wherein the method includes: generating a set of genetic complexes within individual wells of the array of wells.Type: GrantFiled: October 13, 2022Date of Patent: January 9, 2024Inventors: Kalyan Handique, Vishal Sharma, Priyadarshini Gogoi, William Chow, Austin Payne, Kyle Gleason, Brian Boniface, John Connolly, Sam Tuck
-
Patent number: 11859237Abstract: A method for sizing a DNA molecule is disclosed, which comprises the following steps of: providing a DNA sizing device, comprising: a cover substrate; a substrate disposed on the cover substrate and comprising a first hole and a second hole; and a first slit-like channel disposed between the cover substrate and the substrate, wherein two ends of the first slit-like channel respectively connects to the first hole and the second hole; loading a sample comprising a DNA molecule to the first slit-like channel through the first hole, wherein the DNA molecule moves in a direction from the first hole to the second hole; detecting and recording an intensity and an area of a distribution of the DNA molecule; and analyzing the intensity and the area to obtain the size of a DNA molecule.Type: GrantFiled: November 8, 2019Date of Patent: January 2, 2024Assignee: ACADEMIA SINICAInventors: Chia-Fu Chou, Jia-Wei Yeh, Yii-Lih Lin
-
Patent number: 11845076Abstract: A system for ejecting tips of sampling pipettes, the system comprising: —a button for ejecting a tip which is intended to be moved in translation by an operator's thumb; —a tip ejection device; and —return spring for returning the tip ejection device to a raised position. According to the invention, the system also comprises a lever for controlling the ejection device, the control lever comprising: —a first end which is intended to be fitted onto a part of the pipette; —a second end cooperating with the eject button so as to be acted upon by the latter; and —an intermediate portion for actuating the ejection device.Type: GrantFiled: May 3, 2019Date of Patent: December 19, 2023Assignee: GILSON SASInventor: Hervé Malvoisin
-
Patent number: 11839363Abstract: Disclosed is an integrated device for faeces sampling and occult blood detection, which has functions of quantitative collection, dissolution, filtration, detection with immune test strips of the faecal sample, and is convenient to carry and operate, and the device does not leak any liquid during storage, transportation and detection. The device can accurately collect a constant sample with no pollution and leakage, and can quickly determine results of occult blood without the aid of other items. The device can detect faecal occult blood at any time and at any place, can help to overcome the problem of low rate of inspection due to the inconvenience of faeces submission and inspection, further promote the detection of faecal occult blood, and can improve the early diagnosis and screening rate of colorectal cancer of the population.Type: GrantFiled: April 25, 2022Date of Patent: December 12, 2023Assignee: Hangzhou New Horizon Health Technology Co. Ltd.Inventors: Yiyou Chen, Bin Li, Shuidi Zhong
-
Patent number: 11833455Abstract: A separation recovery system for separating and recovering an object to be separated includes a metal porous membrane which has a first principal surface and a second principal surface facing the first principal surface and has a plurality of through-holes extending between the first principal surface and the second principal surface, a supply device which supplies a first fluid containing the object to be separated from the first principal surface of the metal porous membrane toward the second principal surface, and a backwash device which supplies a second fluid containing a plurality of particles larger than a size of the plurality of through-holes of the metal porous membrane in a direction from the second principal surface of the metal porous membrane toward the first principal surface.Type: GrantFiled: December 13, 2022Date of Patent: December 5, 2023Assignee: MURATA MANUFACTURING CO., LTD.Inventors: Seiji Kamba, Takashi Kondo, Masaru Banju
-
Patent number: 11828755Abstract: In various embodiments methods and devices are provided for the detection and/or quantification of an analyte. In certain embodiments a device is provided comprising an aqueous two-phase system (ATPS) comprising a mixed phase solution that separates into a first phase solution and a second phase where, in use, said first phase solution becomes a leading phase and said second phase solution becomes a lagging phase; a lateral-flow assay (LFA); and a probe and/or a development reagent, where in use, said probe associates with said first phase solution in said leading phase of said ATPS and/or said development reagent associates with said second phase solution in said lagging phase of said ATPS. In certain embodiments a “one-pot” system of purifying and amplifying a nucleic acid is provided utilizing, e.g., an ATPS and isothermal amplification reagents.Type: GrantFiled: June 7, 2017Date of Patent: November 28, 2023Assignee: The Regents of the University of CaliforniaInventors: Daniel Takashi Kamei, Benjamin Ming Wu, Daniel William Bradbury, Shin Ting Sherine Frieda Cheung
-
Patent number: 11826752Abstract: One object of the present invention is to provide a method or apparatus for purifying target particles from high-concentration particles in a short time. The above problem can be solved by a method for purifying target particles, characterized in that the method comprises a step of sorting the target particles from a high concentration of non-target particles, wherein the sorting step is repeated for three times or more.Type: GrantFiled: August 24, 2021Date of Patent: November 28, 2023Assignee: ON-CHIP BIOTECHNOLOGIES CO., LTD.Inventors: Kazuo Takeda, Masayuki Ishige, Yuu Fujimura, Takahide Ino, Yuji Morishita, Kosuke Osawa, Soichiro Tsuda
-
Patent number: 11815511Abstract: A time-resolved fluorescence kit for synchronously detecting 4,15-diacetoxyscirpenol, deoxynivalenol and T-2 toxin. The kit includes an immunochromatography time-resolved fluorescence test strip and a sample reaction bottle containing freeze-dried products of europium-labeled monoclonal antibodies of toxins, where the immunochromatography time-resolved fluorescence test strip includes a liner, where a water absorption pad, a detection pad and a sample pad are sequentially attached to one side of the liner from top to bottom, adjacent pads are connected in an overlapping manner at a joint, the detection pad uses a nitrocellulose membrane as a base pad, a transverse quality control line and detection lines are arranged on the nitrocellulose membrane from top to bottom, the quality control line is coated with a rabbit antimouse polyclonal antibody, the three detection lines are located below the quality control line, and the detection lines each are coated with a toxin-protein conjugate.Type: GrantFiled: November 16, 2020Date of Patent: November 14, 2023Assignee: OIL CROPS RESEARCH INSTITUTE, CHINESE ACADEMY OF AGRICULTURAL SCIENCESInventors: Qi Zhang, Xiaoqian Tang, Yizhen Bai, Wen Zhang, Peiwu Li
-
Patent number: 11808758Abstract: Apparatus and methods are described including placing a sample into a sample carrier that comprises a plurality of regions having upper and lower surfaces, having respective heights that are different from each other, and being configured such that cells form a monolayer, the monolayer within respective regions of the sample carrier having respective, different densities from each other, due to the respective regions of the sample carrier having respective heights that are different from each other. Microscopic images are acquired of each of the plurality of regions. Measurements are performed upon cell types that have a relatively high density upon microscopic images of a region of the sample chamber having a relatively low height, and measurements are performed upon cell types that have a relatively low density upon microscopic images of a region of the sample chamber having a relatively great height. Other applications are also described.Type: GrantFiled: October 28, 2020Date of Patent: November 7, 2023Assignee: S.D. Sight Diagnostics Ltd.Inventors: Joseph Joel Pollak, Sarah Levy Schreier, Yochay Shlomo Eshel, Amir Zait, Sharon Pecker, Trevor Ruggiero
-
Patent number: 11808711Abstract: The present disclosure relates to a colorimetric humidity sensor and a method of preparing the same, and in the colorimetric humidity sensor that is an ultrafast colorimetric humidity sensor including a colorimetric member including humidity-responsive particles configured in a disordered monolayer arrangement on a substrate, the humidity-responsive particles are amorphous, porous, and polydispersed microspheres, and the colorimetric humidity sensor indicates a color change according to humidity upon light irradiation.Type: GrantFiled: May 23, 2022Date of Patent: November 7, 2023Assignee: EWHA UNIVERSITY—INDUSTRY COLLABORATION FOUNDATIONInventors: Jerome Kartham Hyun, Syazwani Mohd Noor, Han-Sol Jang, Jin-Ho Choy
-
Patent number: 11788985Abstract: Some embodiments presented here relate to chemical sensors with enhanced sensitivity and selectivity. In an embodiment, the sensor is a composite thin film that comprises (e.g., is made of) chemically-modified carbon black and a chemically-sensitive polymer base. By grafting gold nanoparticles on carbon black, the number of binding sites on the sensor thin film is increased, thereby increasing the sensitivity. Furthermore, ligand attached gold nanoparticles are grafted on carbon black to increase the binding sites on the sensor thin film in some embodiments, which results in increased sensitivity as well as improved selectivity in some cases.Type: GrantFiled: February 7, 2019Date of Patent: October 17, 2023Assignee: Stratuscent Inc.Inventors: Nicolas Levaray, Jayan Ozhikandathil, Ashok Prabhu Masilamani, Tullio Panarello
-
Patent number: 11759786Abstract: According to an example aspect of the present invention, there is provided an apparatus for mounting a device on a manipulator, wherein a second unit is adjustably attached to a first unit so that it is movable in at least one direction with respect to the base plate and wherein the first unit has at least a locked position and an open position, the mounting rail being movable with respect to the first unit when the first unit is in the open position and wherein the mounting rail is fixed with respect to the first unit when the first unit is in the closed position.Type: GrantFiled: January 29, 2021Date of Patent: September 19, 2023Assignee: Sartorius Biohit Liquid Handling OyInventor: Anssi Häärä
-
Patent number: 11760088Abstract: A liquid discharge apparatus includes a drive signal generation section configured to generate a plurality of drive pulses that is supplied to a pressure generation unit to change a pressure in liquid in a pressure chamber communicated with a nozzle. The plurality of drive pulses include: first and second discharge pulses to discharge liquid from the nozzle; and first and second micro-vibration pulses to not discharge liquid. The first discharge pulse and the first micro-vibration pulse are included in a first period included in a repetition cycle. The second discharge pulse and the second micro-vibration pulse are included in a second period included in the repetition cycle and later than the first period. The length from a start of the first period to the first micro-vibration pulse differs from the length from a start of the second period to the second micro-vibration pulse.Type: GrantFiled: July 16, 2021Date of Patent: September 19, 2023Assignee: Seiko Epson CorporationInventors: Shushi Makita, Masako Fukuda
-
Patent number: 11751855Abstract: A collector for collecting urine samples is placed inside a toilet with an extension lip placed on a toilet seat disposed on top of the toilet. Upon collecting urine inside the collector, a sample of urine is extracted from inside the collector. The collector may include a socket. The sealed container may be inserted into the socket to extract the sample of urine. A hollow sleeve may be disposed inside or outside the collector. Urine disposed inside the collector and inside the sleeve may attain the same fluid level responsive to a fluid passage between the collector and the sleeve at the bottom of the collector. The volume of urine extracted from the sleeve may be proportional to the urine collected inside the collector with a known proportionality constant.Type: GrantFiled: June 18, 2020Date of Patent: September 12, 2023Inventor: Varda Margalit Aberbach
-
Patent number: 11753672Abstract: The present invention discloses a swab sample nucleic acid releaser and use thereof. The sample releaser includes 1-20 mol/L of a metal ion chelating agent, 5-80 mmol/L of a buffer at pH 6-9, 5%-40% (v/v) of a polar organic solvent, 0.2%-10% (v/v) of a surfactant, and 0.1-1 mol/L of a nuclease inhibitor. The sample releaser can integrate three steps of sampling and preservation, inactivation, and nucleic acid extraction into one step, and after sampling, the sample can be directly put into a sampling tube equipped with the sample releaser for storage and transportation; and when in use, the sampling tube is turned upside down and mixed well, and after the sample and the sample releaser are fully mixed, it is let stand for a few minutes at room temperature to release the nucleic acid of the sample.Type: GrantFiled: October 27, 2020Date of Patent: September 12, 2023Assignee: DA AN GENE CO., LTD.Inventors: Yunshao He, Xiwen Jiang, Qiao Xia, Zhiqiang Dong, Lili Liao, Hanrong Li
-
Patent number: 11730678Abstract: A vial adaptor and needle assembly are disclosed for use with a vial containing a medication, such as insulin. The vial adaptor may include a needle opening configured to receive a needle of a geometrically corresponding needle assembly to withdraw the medication from the vial in a secured manner. The vial adaptor may also include a cleaning passageway configured to receive a cleaning device to clean the vial.Type: GrantFiled: August 18, 2017Date of Patent: August 22, 2023Assignee: Eli Lilly and CompanyInventors: Keith Daniel Alsberg, Christopher John DeMaria, Kenneth James Micklash, II, Gary Harlan Paulsen
-
Patent number: 11726041Abstract: A method for measuring optical signal detector performance that includes directing light emitted from an optical signal detector onto a first non-fluorescent surface portion in a first detection zone of the optical signal detector. A first characteristic of light detected by a first sensor of the first optical signal detector is measured while the first non-fluorescent surface portion is in the first detection zone of the optical signal detector. Light emitted from the optical signal detector is directed into a first void in the first detection zone of the optical signal detector. A second characteristic of light detected by the first sensor of the optical signal detector is measured while the first void is in the first detection zone of the optical signal detector. And an operational performance status of the optical signal detector is determined based on at least one of the first characteristic and the second characteristic.Type: GrantFiled: June 14, 2022Date of Patent: August 15, 2023Assignee: GEN-PROBE INCORPORATEDInventors: David Opalsky, Srajan Raghuwanshi, James Bui
-
Patent number: 11714096Abstract: An automated carousel and system configured for translationally moving a plurality of biological production units in unison along a vertical frame while maintaining a precise alignment of each of the biological production units relative to gravity, and simultaneously providing independent dynamic adjustment of the axial orientation of each of the plurality of biological production units relative to gravity. The automated carousel may be adapted for use with a variety of biological production units supporting cell culture and/or tissue engineering systems in various clinical and laboratory settings and provides for ergonomic use thereof.Type: GrantFiled: December 18, 2019Date of Patent: August 1, 2023Assignee: OCTANE BIOTECH INC.Inventors: Timothy Smith, Ian Grant, Guy Oram, Chase McRobie, Raelyn Daniels, Taylor Plant
-
Patent number: 11698342Abstract: Disclosed is a method for analysing FluoroSpot assays. The method comprises illuminating a well of an assay plate with at least one excitation light, capturing at least one image of the well, in raw image format, for each excitation light, generating a model of analyte release distribution in the well for each excitation light, and clustering a plurality of co-positioned fluorospots as a multiple secretion fluorospot, wherein the clustering is performed for all generated models, and wherein the clustering determines at least one multiple secretion fluorospot. The generation of the model of analyte release distribution for a given excitation light comprises deconvolving the captured at least one image of the well to estimate a pre-diffusion analyte distribution, and detecting potential analyte release sites based on local maxima therein.Type: GrantFiled: June 27, 2018Date of Patent: July 11, 2023Assignee: MABTECH ABInventors: Christian Smedman, Joakim Jalden, Daniel Pelikan, Pol Del Aguila Pla, Klas Magnusson
-
Patent number: 11696702Abstract: A system is provided that includes a portable measurement device for measuring acetone in a breath sample of a user. The measurement device comprises a housing, a user-direct breath input device for engaging in direct fluid communication with a respiratory tract of the user and receiving the breath sample from the respiratory tract, a flow path disposed within the housing, a nanoparticle-based sensor disposed in the housing in fluid communication with the flow path and at an intermediate location between the upstream end and the downstream end, and a flow control device disposed in the housing and in the flow path between the upstream end and the nanoparticle-based sensor that prevents flow of the breath sample in an upstream direction opposite the downstream direction.Type: GrantFiled: May 27, 2020Date of Patent: July 11, 2023Assignee: Invoy Holdings Inc.Inventors: Lubna M. Ahmad, Rhett L. Martineau, Salman A. Ahmad, Zachary Smith
-
Patent number: 11691148Abstract: A microfluidic device in which microfluidic channels are embedded in a culture medium chamber and have open sides. The microfluidic device is patterned with a fluid moved along a hydrophilic surface due to capillary force, and the fluid may be rapidly and uniformly patterned along an inner corner path and a microfluidic channel. In the microfluidic device, the microfluidic channel is connected to facilitate fluid flow with a culture medium through open sides thereof and openings, and thus may provide a cell culture environment in which high gas saturation is maintained. In addition, several microfluidic devices formed on one common substrate are described. Such microfluidic devices may be manufactured of a hydrophilic engineering plastic by injection molding.Type: GrantFiled: July 12, 2022Date of Patent: July 4, 2023Assignee: CURIOCHIPSInventors: Noo Li Jeon, Byungjun Lee, James Yu, Jihoon Ko
-
Patent number: 11693019Abstract: Disclosed is an automated liquid-phase immunoassay apparatus used with a cuvette having a plurality of chambers containing a reagent necessary for detection of an analyte in a biological specimen. The apparatus includes a movable cuvette module equipped with the cuvette, an optical reading module for optical assaying of a material resulting from a reaction between the specimen and the reagent, and a dispenser module which is positioned on the cuvette module and which dispenses the specimen and the reagent to the plurality of chambers of the cuvette and washes the specimen and the reagent therefrom.Type: GrantFiled: April 23, 2021Date of Patent: July 4, 2023Assignee: BODITECH MED INC.Inventors: Eui Yul Choi, Hoo Don Joo, Hyung Hoon Kim, Chuhyun Cho, Uk Bin Im, Young Jin Oh, Youn Tae Im, Ji Woon Jung
-
Patent number: 11680921Abstract: A sensor for sensing diols and triols includes (a) a substrate, (b) a conductive coating disposed on the substrate and having affinity for binding with a substance selected from the group consisting of diols, triols, and a combination thereof, and (c) two electrodes in contact with the conductive coating to probe conductivity of the conductive coating so as to detect the substance from a reduction in the conductivity. A method for detecting vaping includes (a) measuring conductivity of a conductive coating having affinity for binding with an airborne substance selected from the group consisting of diols, triols, and a combination thereof, and (b) detecting presence of the airborne substance as a decrease in the conductivity.Type: GrantFiled: October 17, 2019Date of Patent: June 20, 2023Assignee: FreshAir Sensor, LLCInventors: Joseph J. BelBruno, Andrei Burnin, Katie Shelton, Matthew Curtin, Jacob Fisher
-
Patent number: 11672440Abstract: Disclosed herein is a device detecting volatile organic compounds, such as acetone, using nanostructured K2W7O22 crystals. Methods for detecting a subject in a state of ketosis, such as diabetes, using a volatile organic sensing device are disclosed. A method for synthesizing K2W7O22 nanostructured sensing crystals is further disclosed.Type: GrantFiled: September 5, 2019Date of Patent: June 13, 2023Assignee: NDSU RESEARCH FOUNDATIONInventors: Danling Wang, Qifeng Zhang
-
Patent number: 11674869Abstract: Devices and methods for analyzing a sample are disclosed. In various embodiments, the present disclosure provides devices and methods for preparing a serial dilution of a sample. In various embodiments, the present disclosure provides devices and methods for preparing a serial dilution of a sample and conducting sample analysis. In various embodiments, the present disclosure provides a cartridge device and a reader instrument device. The reader instrument device receives, operates, and/or actuates the cartridge device to prepare a serial dilution of a sample and conduct sample analysis.Type: GrantFiled: February 26, 2019Date of Patent: June 13, 2023Assignee: CYTOCHIP, INC.Inventors: Wendian Shi, Yuan Gao, Yuzhe Ding
-
Patent number: 11674928Abstract: An acoustic sensor detects binding of a nucleic acid analyte in an impure liquid sample by measurement of the energy of the acoustic wave resulting from the binding of the nucleic acid target to the sensor surface. The analysis may be preceded by carrying out a nucleic acid amplification procedure in situ on a crude or impure biological sample and the analysis is tolerant of the presence of reagents or by-products of the amplification procedure, and also materials present from the initial biological sample.Type: GrantFiled: June 18, 2018Date of Patent: June 13, 2023Assignee: Foundation for Research and Technology HellasInventors: Georgios Papadakis, Electra Gizeli
-
Patent number: 11668726Abstract: A system and method for treatment of biological samples is disclosed. In some embodiments, an automated biological sample staining system (100), comprising at least one microfluidic reagent applicator (118); at least one bulk fluid applicator (116); at least one fluid aspirator; at least one sample substrate holder; at least one relative motion system; and a control system (102) that is programmed to execute at least one staining protocol on a sample mounted on a substrate that is held in the at least one sample substrate holder.Type: GrantFiled: April 18, 2019Date of Patent: June 6, 2023Assignees: Ventana Medical Systems, Inc., Roche Diagnostics Operations, Inc.Inventors: Andreas Drechsler, Oliver Gutmann, Melis Hazar, Reto Huesser, Raymond T. Kozikowski, III, Daniel Mueller, Chris Steinert
-
Patent number: 11666841Abstract: Nanofiber filter media ribbons are flexible elongate strips of polymeric material having a surface on which is formed an array of nanofibers. Ribbons are formable into woven or non-woven mats. The array of nanofibers can be configured to filter a predetermined contaminant from a fluid stream passing through the mats. Filter ribbons are formable by applying a moldable polymer to a first angular location of a rotating cylindrical roll having an array of nanoholes formed in a circumferential surface thereof so that the polymer covers the surface of the roll and infiltrates the nanoholes; cooling the polymer while rotating the polymer-covered roll to a second angular position; and removing the cooled polymer from the roll as an elongate film having an array of nanofibers formed on a surface thereof by the polymer that infiltrated the nanoholes.Type: GrantFiled: May 3, 2021Date of Patent: June 6, 2023Assignee: ULTRA SMALL FIBERS, LLCInventors: William H. Hofmeister, Robert A. Van Wyk, Collin Anderson
-
Patent number: 11666938Abstract: Disclosed is a liquid patterning device and liquid patterning method. The liquid patterning device includes: a substrate having a flat bottom and a surface; at least one microstructure formed to vertically protrude from the surface of the substrate and including a plurality of unit microposts so as to have a desired shape; and a liquid mover for moving a liquid to be patterned on the surface of the substrate in another direction from one direction of the microstructure.Type: GrantFiled: March 18, 2021Date of Patent: June 6, 2023Assignee: CURIOSIS Co., Ltd.Inventors: Ho Young Yun, Myeong Woo Kang, Noo Li Jeon
-
Patent number: 11658000Abstract: There is provided a sample support capable of easily placing a sample into position. The sample support is used such that a sample floating on the surface of water is scooped and held. The sample support has: a first region on which the sample is to be placed; and a second region of higher wettability than the first region.Type: GrantFiled: June 30, 2020Date of Patent: May 23, 2023Assignee: JEOL Ltd.Inventors: Yuji Konyuba, Tomohiro Haruta, Yuta Ikeda, Tomohisa Fukuda
-
Patent number: 11654437Abstract: The present disclosure provides an assay cartridge used in a PCR-based molecular diagnostic device. In one embodiment, the assay cartridge comprises (1) an elongated body having a proximal end, a distal end and a plurality of compartments arranged between the proximal end and the distal end, said plurality of compartments include at least a first pipette tip holder near the proximal end, and a second pipette tip holder near the distal end; and (2) a seal assembly covering the elongated body comprising a rigid frame which matches the top periphery of the elongated body, and an elastic top mounted on the rigid frame, the elastic top comprising a first sub-portion near the proximal end comprising a first ring structure that matches the first pipette holder, and a second sub-portion near the distal end comprising a second ring structure that matches the second pipette holder.Type: GrantFiled: October 23, 2019Date of Patent: May 23, 2023Assignee: QUANDX INC.Inventors: Xiaojun Lei, Qian Xu
-
Patent number: 11641803Abstract: The invention relates to a method and system for picking up and collecting plant matter, in particular plant embryos. To pick up the plant matter, a pick-up unit is used that is mounted to a robotic arm. According to the invention, two separate imaging steps are performed at two different positions of the pick-up unit. The first imaging step is performed to identify an isolated piece of plant matter. The second imaging step is performed when the pick-up unit is at a confirming position and enables a verification of whether a piece of plant matter has been picked up or not. The confirming position is in between the position of the pick-up unit for picking up plant matter and the position for depositing plant matter in suitable receptacles.Type: GrantFiled: April 8, 2019Date of Patent: May 9, 2023Assignee: RIJK ZWAAN ZAADTEELT EN ZAADHANDEL B.V.Inventors: Wilhelmus Petrus Adrianus Roeland Voermans, Mark Van Den Berg, Kevin Cornelis Adrianus Gerardus Verbocht
-
Patent number: 11630035Abstract: A system and method for automated transfer of a tape segment onto the face of a tissue block to be thin sectioned by microtomy includes applying, to a carrier strip, a plurality of serially-spaced patches of sample tape having an adhesive outer surface, transporting the carrier strip along a path adjacent to and spaced from the exposed sample surface to position one of the patches of sample tape adjacent to and covering the exposed sample surface, adhering the one of the patches of sample tape to the exposed sample surface.Type: GrantFiled: November 1, 2019Date of Patent: April 18, 2023Assignee: Clarapath, Inc.Inventors: Partha P. Mitra, Alexander S. Tolpygo, Robert L. Kleinberg
-
Patent number: 11630107Abstract: A method and system for detecting a target component by using a mobile terminal, and a detection method for simultaneously screening multiple target objects.Type: GrantFiled: May 13, 2022Date of Patent: April 18, 2023Assignee: Institute of Quality Standard and Testing Technology for Agro- Products, CAASInventors: Zhen Cao, Jing Wang
-
Patent number: 11624740Abstract: A small-sized, portable enclosure protects a gas sensor against degradation due to environmental exposure and changes in atmospheric conditions. The protective enclosure includes an inlet for introduction of a gas into the enclosure, an outlet for release of the gas upon completion of a sensing run, and a number of in-line filters that remove from the inflowing gas sample analytes, contaminants, and other materials that can compromise the integrity of the sensor or cause the sensor to degrade over time. The enclosure does not include any filters during the measurement phase of the sensing run in order to allow the gas sensor to accurately measure an unmodified gas mixture and/or analyte.Type: GrantFiled: July 17, 2020Date of Patent: April 11, 2023Assignees: International Business Machines Corporation, The University of Melbourne, Technische Universiteit EindhovenInventors: Thomas Geoffrey Pattison, Tom Van der Pol, Linda Karin Sundberg, Krystelle Lionti, Andrea Fasoli, Luisa Dominica Bozano
-
Patent number: 11613723Abstract: The present invention relates to a device for cultivating cells, in particular tissue, comprising a carrier plate unit which has a central axis of rotation, at least one access opening arranged proximally to the axis of rotation, at least one cultivation chamber arranged distally to the axis of rotation, and at least one channel connecting the access opening to the cultivation chamber, and also a method for cultivating cells in a device according to the invention and a method for producing the device according to the invention.Type: GrantFiled: June 13, 2018Date of Patent: March 28, 2023Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.Inventors: Peter Loskill, Oliver Schneider, Stefan Schneider
-
Patent number: 11612340Abstract: A system for verifying a sample volume includes a sample reservoir and a volumetric verification device. The sample reservoir defines an inner volume and is configured to receive a volume of bodily fluid. The inner volume of the sample reservoir contains an additive. The volumetric verification device includes a first indicator and a second indicator. The volumetric verification device is configured to selectively engage the sample reservoir to (1) place the first indicator in a first position along a length of the sample reservoir such that the first indicator is substantially aligned with a surface and/or meniscus of the additive and (2) place the second indicator in a second position along the length of the sample reservoir such that the second indicator is substantially aligned with a predetermined fill volume when bodily fluid is transferred to the inner volume.Type: GrantFiled: December 20, 2018Date of Patent: March 28, 2023Assignee: Magnolia Medical Technologies, Inc.Inventors: Gregory J. Bullington, Shan E. Gaw, Jay M. Miazga, Shannon E. Eubanks
-
Microfluidic sample chip, assay system using such a chip, and PCR method for detecting DNA sequences
Patent number: 11607684Abstract: A microfluidic sample chip to test biological samples, especially for a PCR-type and/or fluorescence assay. The chip being in the shape of a hollow block having at least one chamber delimited by an upper wall, a lower wall and at least one side wall, into which a sample can be introduced for testing. The lower wall of the block is made of a material with a high thermal conductivity and the upper wall is made of a material with a low thermal conductivity. Preferably, the upper wall is preferably permeable to radiation in the visible spectrum between 400 and 700 nm. The block having at least two openings through which the sample can be introduced into at least one of the chambers and through which the air present in the chamber can be evacuated when the sample is introduced.Type: GrantFiled: December 12, 2021Date of Patent: March 21, 2023Assignee: BFORCUREInventor: Maël Le Berre -
Patent number: 11604204Abstract: The present technology is directed to extraction devices, systems, and methods for controllably withdrawing and transferring fluid samples, such as blood, from a sample collection container to a testing device. For example, some embodiments of the present technology provide fluid extraction devices that include a fluid control module, a housing containing a receiving element and a suction element, and an actuator. To transfer blood from a sample collection container to a testing device, a user places the sample collection container over the receiving element and inserts the testing device into an outlet of the fluid control module. The user then pushes a lever or otherwise actuates the actuator, which automatically withdraws a predetermined volume of blood from the sample collection container and transfers it to the testing device positioned at the outlet of the fluid control module.Type: GrantFiled: May 29, 2020Date of Patent: March 14, 2023Assignee: University of WashingtonInventor: Steven Bennett
-
Patent number: 11598775Abstract: A rapid immunoassay method and apparatus for detecting foot and mouth disease virus are disclosed. The method and test device permit pen-side testing of animals and provide test results within a relatively short time period. In a preferred embodiment, the method and apparatus provide a means for differentiating between FMDV-infected and FMDV-vaccinated animals.Type: GrantFiled: July 9, 2018Date of Patent: March 7, 2023Assignee: Princeton BioMeditech CorporationInventors: Jemo Kang, Ki-Yong Jang