Oxygenator Patents (Class 422/45)
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Patent number: 7736494Abstract: An ozone delivery system for delivering and manufacturing a measured amount of an ozone/oxygen admixture, which is able to measure, control, report and differentiate between delivered-ozone and absorbed-dose of ozone. Improved gas-fluid contacting devices that maximize gas-fluid mass transfer may be included. All gas contacting surfaces of the system, including one or more gas-fluid contacting devices are made from ozone-inert construction materials that generally do not absorb ozone or introduce amounts of contaminants or deleterious byproducts of oxidation into a fluid or non-fluid target from ozone oxidation.Type: GrantFiled: October 11, 2004Date of Patent: June 15, 2010Assignee: AcquiSci, Inc.Inventors: Joseph S. Latino, Steven A. Keyser
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Publication number: 20100143192Abstract: This invention discloses a modular system having a base module, a mid-section control module, and a display module for preparing and administering a gas-enriched bodily fluid. Gas-enrichment is achieved by a gas-enriching device which can be in the form of a disposable cartridge. During operation, the gas-enrichment device is placed in an enclosure within the control module. An electronic controller manages the various aspects of the system such as the production of gas-enriched fluid, flow rates, bubble detection, and automatic operation and shut down. The system includes a combination bubble detector/flow meter that uses a single ultrasonic probe for detecting bubbles and measuring fluid flow rate.Type: ApplicationFiled: December 4, 2008Publication date: June 10, 2010Applicant: THEROX, INC.Inventors: Stephen E. Myrick, Gregory P. Watson, Jeffrey L. Creech
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Publication number: 20100143191Abstract: This invention discloses a modular system having a base module, a mid-section control module, and a display module for preparing and administering a gas-enriched bodily fluid. An apparatus adapted for connecting with a gas tank is included in the system for gas tank hook-up. Gas-enrichment is achieved by a gas-enriching device which can be in the form of a disposable cartridge. During operation, the gas-enrichment device is placed in an enclosure within the control module. An electronic controller manages the various aspects of the system such as the production of gas-enriched fluid, flow rates, bubble detection, and automatic operation and shut down. The system has a power supply for providing electrical power to the system, and a switching mechanism coupled to the power supply and gas tank for synchronized switching of the power supply and the gas tank between an ON state and an OFF state.Type: ApplicationFiled: December 4, 2008Publication date: June 10, 2010Applicant: THEROX, INC.Inventors: Stephen E. Myrick, Gregory P. Watson, Achilles V. Young
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Publication number: 20100143190Abstract: This invention discloses a modular system having a base module, a mid-section control module, and a display module for preparing and administering a gas-enriched bodily fluid via an extracorporeal circuit. Gas-enrichment is achieved by a gas-enriching device which can be in the form of a disposable cartridge. During operation, the gas-enrichment device is placed in an enclosure within the control module. An electronic controller manages the various aspects of the system such as the production of gas-enriched fluid, flow rates, bubble detection, and automatic operation and shut down. The controller is capable of detecting occlusions in the extracorporeal circuit and responding to different occlusion conditions to prevent forced shutdown/re-priming of the circuit.Type: ApplicationFiled: December 4, 2008Publication date: June 10, 2010Applicant: THEROX, INC.Inventors: Stephen E. Myrick, Gregory P. Watson
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Patent number: 7713412Abstract: A hollow fiber filter device for dialysis having a housing and an end cap is described. The end cap is attached to an axial end of the housing, and has a curved channel in fluid communication with a fluid port, a fluid chamber having a flow path defined by a plurality of curved members connected to an upper interior surface. The distance between circumferentially adjacent curved members may decrease in a radially outward flow direction.Type: GrantFiled: May 9, 2008Date of Patent: May 11, 2010Assignee: Fresenius Medical Care Deutschland GmnHInventors: Klaus Heilmann, Gerhard Breith, Igor Raiko, Roland Sander, Steffen Fritzsche
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Patent number: 7708942Abstract: A method and apparatus for performing coronary perfusion and cardiac reoxygenation that enables accurate control of oxygen levels in blood used for the coronary circulation. Deoxygenated blood and oxygenated blood are collected and oxygen levels are measured by sensors. The deoxygenated and oxygenated blood is then mixed and the mixed blood is measured by another sensor. The sensors provide data used to provide real-time oxygen level measurement and adjustment for blood supplied for coronary circulation.Type: GrantFiled: February 12, 2008Date of Patent: May 4, 2010Assignee: Rheoxtech, LLCInventor: Neil J. Thomas
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Patent number: 7682327Abstract: The present invention provides a heart-lung machine which can be carried by one person and can be used independently from an external power supply, consisting of at least three modules (1, 2, 3), wherein a first module (1) contains the blood circulating elements which are necessary for the function of a heart-lung machine, a second module (2) contains a pump drive (9) and an electronic measuring equipment and a control logic (11) and a third module (3) contains the programming unit (14), whereas the second unit is separably connected to the first and the third module.Type: GrantFiled: May 6, 2004Date of Patent: March 23, 2010Assignee: Lifebridge Medizintechnik AGInventor: Karsten Kirchhof
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Patent number: 7682563Abstract: A disposable, integrated extracorporeal blood circuit employed during cardiopulmonary bypass surgery performs gas exchange, heat transfer, and microemboli filtering functions in a way as to conserve volume, to reduce setup and change out times, to eliminate a venous blood reservoir, and to substantially reduce blood-air interface. Blood from the patient or prime solution is routed through an air removal device that is equipped with air sensors for detection of air. An active air removal controller removes detected air from blood in the air removal device. A disposable circuit support module is used to mount the components of the disposable, integrated extracorporeal blood circuit in close proximity and in a desirable spatial relationship to optimize priming and use of the disposable, integrated extracorporeal blood circuit. A reusable circuit holder supports the disposable circuit support module in relation to a prime solution source, the active air removal controller and other components.Type: GrantFiled: February 14, 2007Date of Patent: March 23, 2010Assignee: Medtronic, Inc.Inventors: Walter L. Carpenter, Robert W. Olsen, Frederick A. Shorey, Jr., Mark G. Bearss, Bruce R. Jones, Laura A. Yonce
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Patent number: 7641853Abstract: An intravenous oxygenator for enriching blood with oxygen, said oxygenator having a bundle of fibers, said fibers being each connected to a gas supply means through a first connection and to a gas evacuation means through a second connection, with the fiber bundle being twisted during operation by relative rotation of the first connections of the fibers relative to the second connections of the fibers about a longitudinal axis of the oxygenator. Further, an intravenous oxygenator for insertion into a vein, the connections being respectively connected to a first and to a second fiber holder and being displaceable along a longitudinal axis of the oxygenator, with the fiber holders being mounted so as to be rotatable relative to one another about the longitudinal axis of the oxygenator. Such a constellation permits particularly efficient gas exchange.Type: GrantFiled: July 22, 2003Date of Patent: January 5, 2010Assignee: novalung GmbHInventors: Gjorgio Cattaneo, Helmut Reul, Sylvia Ruth Reul-Freudenstein, legal representative, Rüdiger Autschbach
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Patent number: 7621407Abstract: A blood filter system used for the sequential filtering of blood while actively removing air bubbles and debris comprising a filter housing with unique conical, or cylindrical shape, a flared inlet port, a unique up and down blood flow path, a multi-stage sequential filter assembly, an active air purge assembly and a unique downspout assembly with outlet port. The filter housing is adapted so that blood passes from the inlet port through the multi-stage sequential filter assembly to the outlet port following an up and down flow path, while its unique shape and angled filters effectively direct any air bubbles and debris up and out of the blood stream toward the active air purge assembly where they are removed.Type: GrantFiled: March 23, 2007Date of Patent: November 24, 2009Inventor: Daniel Patrick Herbst
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Patent number: 7618584Abstract: The invention relates to a bag system for the cryopreservation of body fluids, that is blood, bone marrow or umbilical cord blood, the parts of the bag system being sterilized, and separable from one another, wherein liquids which permit and/or assist cryopreservation are located in the bag system and/or may be introduced into the bag system in a sterile form. The bag system, at least, comprising: a device for the direct removal of body fluid (1) from the living body, a region or number of regions for mixing the liquids with the body fluid and/or for storing the mixture of liquids and body fluid, a number of shut-off elements (2) and connecting lines (3) and an inlet element (4) and/or an outlet element (5).Type: GrantFiled: October 16, 2002Date of Patent: November 17, 2009Assignee: Vita 34 AGInventors: Eberhard Lampeter, Dietmar Egger
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Patent number: 7615028Abstract: An extracorporeal blood treatment system including: a blood circuit having a first blood passage coupled at a first end to a first end of a blood treatment device and a second blood passage coupled at a first end to a second end of the treatment device, wherein the first and second blood passages each have a second end adapted to be coupled to a vascular system of a human patient; a first blood pump connectable to the first blood passage and a second blood pump connectable to the second blood passage, wherein said first and second blood pumps are adapted to move blood through the first and second blood passages in a first direction and in a reverse direction, and a pump controller operatively connected to the first and second blood pumps, said controller operates the blood pumps to cyclically move blood through the first and second blood passages in the first direction and the reverse direction.Type: GrantFiled: December 3, 2004Date of Patent: November 10, 2009Assignee: CHF Solutions Inc.Inventor: John J. O'Mahony
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Patent number: 7611478Abstract: Continuous volume detection for a reservoir in a fluid circuit of a medical system is described. Volume detection is based on a pressure measurement that is manipulated via application of fluid mechanics. Next-generation medical system controllers may use this data to control the volume contained in the reservoir.Type: GrantFiled: April 10, 2008Date of Patent: November 3, 2009Assignee: Minnetronix Inc.Inventors: Lori E. Lucke, Matthew J. Cunningham, Richard A. Nazarian
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Patent number: 7572377Abstract: A blood filter system used for the sequential filtering of blood while actively removing air bubbles and debris comprising a filter housing with unique conical, or cylindrical shape, a flared inlet port, a unique up and down blood flow path, a multi-stage sequential filter assembly, an active air purge assembly and a unique downspout assembly with outlet port. The filter housing is adapted so that blood passes from the inlet port through the multi-stage sequential filter assembly to the outlet port following an up and down flow path, while its unique shape and angled filters effectively direct any air bubbles and debris up and out of the blood stream toward the active air purge assembly where they are removed.Type: GrantFiled: August 29, 2008Date of Patent: August 11, 2009Inventor: Daniel Patrick Herbst
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Publication number: 20090175762Abstract: An oxygenator unit includes a venous reservoir, a centrifugal pump, an oxygenator, a connection part for connecting the reservoir and the pump, a connection part for connecting the pump and the oxygenator, and a unit frame. The unit frame includes a reservoir receiving part, a pump receiving part provided at the position under a blood outlet of the venous reservoir disposed at the reservoir receiving part, and an oxygenator receiving part provided at the position in the vicinity of the blood outlet of the centrifugal pump disposed on the pump receiving part. The reservoir is disposed at the reservoir receiving part, the pump is disposed at the pump receiving part; and the oxygenator is disposed at the oxygenator receiving part, and they are held by the unit frame, resulting in a unit.Type: ApplicationFiled: January 6, 2009Publication date: July 9, 2009Applicant: Terumo Kabushiki KaishaInventors: Mitsuaki Ogihara, Norikazu Ishida, Kazuhiko Takeuchi
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Patent number: 7541000Abstract: Apparatus and methods for pumping and oxygenating blood are provided that include a gas removal system. An integrated blood processing unit is provided in which a gas removal/blood filter, pump and blood oxygenation element are mounted within a common housing. The gas removal system includes a sensor mounted on the housing to sense the presence of gas, and a valve is operably coupled to the sensor to evacuate gas from the system when the sensor detects an accumulation of gas.Type: GrantFiled: September 26, 2005Date of Patent: June 2, 2009Assignee: Cardiovention, Inc.Inventors: Steven K. Stringer, Kevin L. Hultquist, Mehrdad Farhangnia, Ben F. Brian, III, Fred I. Linker, James M. Culp, Jean-Pierre Dueri, Thomas A. Afzal
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Publication number: 20090099498Abstract: A cardiopulmonary bypass system utilizing membrane-based reciprocating positive displacement blood pumps (“pod pumps”). In one aspect, the pod pumps are constructed to provide reduced shear forces on the blood being pumped. In another aspect blood flow through the pod pumps can be controlled by a controller using information from pressure sensors in the control chamber of the pod pumps. In another aspect, the pod pumps are included on a disposable unit that can be received and held by a receptacle means on a base unit, the base unit also providing pressurized control fluid to the pod pumps on the disposable unit through the receptacle means.Type: ApplicationFiled: October 10, 2008Publication date: April 16, 2009Applicant: DEKA Products Limited PartnershipInventors: Jason A. Demers, Larry B. Gray, James D. Dale, N. Christopher Perry, David E. Altobelli
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Patent number: 7488302Abstract: A device that allows for serial (time) use of clean blood filters during the use of a heart lung machine. The device is comprised of a series of filters and a switching mechanism that allows the new filter to be placed in the blood flow pathway while at the same time removing the old (previous) filter. A clean filter is always available, and filters for specific components of blood or those able to bind and remove specific biochemicals can be used.Type: GrantFiled: March 28, 2005Date of Patent: February 10, 2009Inventors: Robert Helm, Richard Herink
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Patent number: 7485261Abstract: The present invention is directed to a photolytic artificial lung. The photolytic artificial lung converts water to oxygen for blood absorption, regulates pH, the removes carbon dioxide, and co-produces electrical power is disclosed. The photolytic artificial lung includes a photolytic cell where all of the chemical reactions occur. The photolytic cell disclosed herein can also be used to direct chemical reactions in organs other than the lung. Also disclosed herein is a gas sorption device for removing carbon dioxide from the system by chemical sorption.Type: GrantFiled: September 13, 2004Date of Patent: February 3, 2009Assignees: Battelle Memorial Institute, Pharos, LLCInventors: Bruce F. Monzyk, Kurt Dasse
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Patent number: 7476359Abstract: A device for treating blood in an extracorporeal blood circuit, the device including a centrifugal pump provided with a transparent enclosure that is connected, by means of an inlet duct, to the outlet of a venous reservoir, the venous reservoir having an inlet that is connected to receive blood from a patient. The transparent enclosure of the pump is connected monolithically to the base of a structure that comprises a heat exchanger and an oxygenator. The structure also supports monolithically, at the peripheral region, an arterial filter that receives the blood in output from the oxygenator and is provided with a connector for coupling to an arterial line for return of the blood to the patient.Type: GrantFiled: March 18, 2004Date of Patent: January 13, 2009Assignee: Sorin Group Italia S.r.l.Inventors: Edgardo Costa Maianti, Nicola Ghelli, Ivo Panzani
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Patent number: 7470396Abstract: A device for establishing an isolated perfusion including a pump arrangement, a venous catheter, and an arterial catheter, for establishing an artificial circulation in a target area of a human or animal body, which artificial circulation is isolated from the systemic circulation. The device has first means for feeding an analysis gas into the artificial circulation, and second means for monitoring whether a blood exchange takes place between the artificial circulation and the systemic circulation.Type: GrantFiled: September 25, 2003Date of Patent: December 30, 2008Assignee: Jostra AGInventors: Andreas Meiser, Achim Mumme
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Patent number: 7458952Abstract: A completely integrated cardiopulmonary bypass system includes a common casing provided with a reservoir, a venous air trap, oxygenator, heat-exchanger and a pump. This totally integrated system provides for volume sequestration and for bypassing the reservoir without use of a shunt. The system also provides for open or closed circuit operation, thereby permitting the volume sequestration. The closed circuit operation has a venous air trap for air removal, thus retaining the safety features of both open reservoir and closed-venous air trap systems.Type: GrantFiled: November 14, 2005Date of Patent: December 2, 2008Inventor: Venkataramana Vijay
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Patent number: 7455812Abstract: A method and apparatus for performing coronary perfusion and cardiac reoxygenation that enables accurate control of oxygen levels in blood used for the coronary circulation. Deoxygenated blood and oxygenated blood are collected and oxygen levels are measured by sensors. The deoxygenated and oxygenated blood is then mixed and the mixed blood is measured by another sensor. The sensors provide data used to provide real-time oxygen level measurement and adjustment for blood supplied for coronary circulation.Type: GrantFiled: June 16, 2004Date of Patent: November 25, 2008Assignee: Rheoxtech, LLCInventor: Neil J. Thomas
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Patent number: 7431754Abstract: An artificial lung includes a housing, a tubular hollow fiber membrane bundle contained in the housing and providing a multiplicity of hollow fiber membranes having a gas exchange function, a gas inflow port and a gas outflow port communicating with each other through hollow portions of the hollow fiber membranes, and a blood inflow port and a blood outflow port through which blood is distributed. The tubular hollow fiber membrane bundle has a cylindrical overall shape, and a filter member having a bubble-trapping function is provided on an outer peripheral portion of the tubular hollow fiber membrane bundle.Type: GrantFiled: July 13, 2005Date of Patent: October 7, 2008Assignee: Terumo Kabushiki KaishaInventors: Mitsuaki Ogihara, Hidetaka Nakayama
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Publication number: 20080125689Abstract: The present invention refers to an oximetry and capnography system applied to extracorporeal circulation procedure, more specifically refers to an oximetry and capnography monitoring system associated to gas analyzer applied to ECC, in which a mechanical device (1) based on a tubular circuit (2) is foreseen, and connectors (3) that when duly installed in the equipment operating in ECC have as main purpose to monitor the operation of the gas blender, analyze the oxygenation chamber performance, and check CO2 outflow from the oxygenation chamber in such a way as to prevent collapse within the said oxygenation chamber and therefore, being efficient throughout the ECC procedure.Type: ApplicationFiled: October 24, 2007Publication date: May 29, 2008Inventors: Osvaldo NOGUEIRA SANCHES, Nadia Maria ROCHA MENDES, Gilberto DE OLIVEIRA SCUCIATO
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Patent number: 7364563Abstract: A continuous volume detection system for a flexible venous reservoir in a cardiopulmonary bypass circuit is described. The volume detection system is based on a pressure measurement that is manipulated via application of fluid mechanics. Next-generation cardiopulmonary bypass system controllers may use this data to control the volume contained in the flexible venous reservoir.Type: GrantFiled: October 1, 2004Date of Patent: April 29, 2008Assignee: Minnetronix, Inc.Inventors: Lori E. Lucke, Matthew J. Cunningham, Richard A. Nazarian
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Patent number: 7341568Abstract: The invention relates to a method for determining blood volume during extracorporeal blood circulation, which is based on measuring the propagation rate or propagation time of the pulse waves propagating in the extracorporeal circulation system. The invention preferably involves the measurement of the propagation rate or propagation time of the pulse waves generated by the blood pump, which is placed in arterial branch of the blood line. The device for determining blood volume can make use of the pressure sensor, which is placed in the venous branch of the blood line and which is already provided in prior art blood treatment devices. As a result, the amount of equipment required is relatively low.Type: GrantFiled: May 30, 2003Date of Patent: March 11, 2008Assignee: Fresenius Medical Care Deutschland GmbHInventor: Wei Zhang
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Patent number: 7335334Abstract: A disposable, integrated extracorporeal blood circuit employed during cardiopulmonary bypass surgery performs gas exchange, heat transfer, and microemboli filtering functions in a way as to conserve volume, to reduce setup and change out times, to eliminate a venous blood reservoir, and to substantially reduce blood-air interface. Blood from the patient or prime solution is routed through an air removal device that is equipped with air sensors for detection of air. An active air removal controller removes detected air from blood in the air removal device. A disposable circuit support module is used to mount the components of the disposable, integrated extracorporeal blood circuit in close proximity and in a desirable spatial relationship to optimize priming and use of the disposable, integrated extracorporeal blood circuit. A reusable circuit holder supports the disposable circuit support module in relation to a prime solution source, the active air removal controller and other components.Type: GrantFiled: December 22, 2003Date of Patent: February 26, 2008Assignee: Medtronic, Inc.Inventors: Robert W. Olsen, Walter L. Carpenter, John B. Dickey, Mark D. Stringham
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Publication number: 20070231203Abstract: A filter member used in an oxygenator is constructed to provide improved contact with a hollow fiber membrane bundle and to capture bubbles contained in blood. The filter member possesses elasticity at least in the circumferential direction to allow the inner circumference of the filter member to be increased from a natural non-expanded state prior to placement on the hollow fiber membrane bundle to an expanded state in which the inner circumference of the filter member is increased when placed on the hollow fiber membrane bundle. The filter member is constructed to satisfy the condition 0.5?L2/L1<1, wherein L1 represents the outer circumference of the hollow fiber membrane bundle and L2 represents the inner circumference of the filter member in the natural non-expanded state.Type: ApplicationFiled: March 27, 2007Publication date: October 4, 2007Applicant: Terumo Kabushiki KaishaInventors: Kazuhiro Mizoguchi, Eiji Kato
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Patent number: 7273586Abstract: An apparatus for conditioning mammalian blood for subsequent use in a medical procedure includes a cabinet having a secure environment and a door providing the only access to the environment. An input system transports a blood charge from a source to the cabinet and a flask is removably contained in the secure environment and coupled to the charge input system to receive the charge. Stressors are coupled to the cabinet and positioned for operation to create a conditioned charge in the flask. An output system is coupled to the flask and includes a receiver for the conditioned charge. The apparatus includes an automated control system operable upon closing the door to lock the door and to then condition the charge, and to then cause the charge to move from the flask to the receiver.Type: GrantFiled: December 6, 2005Date of Patent: September 25, 2007Assignee: Vasogen Ireland LimitedInventors: Sonya Mongomery, Jeff Dayman, Allen Muirhead, Paul Moore, Taras Worona, Simon Treadwell, Murray Voakes, Thomas Porter, Carlton Chong, Liung Sen Liao, Duncan Newman
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Publication number: 20070217948Abstract: An integrated device for heating and oxygenating blood in an extracorporeal blood circuit, comprising a shell-and-tube heat exchanger module provided with a coupling to a blood supply line and with two couplings respectively for the intake and discharge of the water designed to exchange heat with the blood; ports are also provided for the passage of the blood toward an oxygenator module of the hollow-fiber type which is located at the peripheral region of the heat exchanger and is provided with a coupling to a blood discharge line; the device further comprises means adapted to direct the flow of blood along a turbulence-free path and with optimum distribution within the two modules.Type: ApplicationFiled: February 26, 2007Publication date: September 20, 2007Inventors: Nicola Ghelli, Edgardo Costa Maianti, Roberto Balanzoni
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Patent number: 7250137Abstract: An apparatus for conditioning mammalian blood for subsequent use in a medical procedure includes a cabinet having a secure environment and a door providing the only access to the environment. An input system transports a blood charge from a source to the cabinet and a flask is removably contained in the secure environment and coupled to the charge input system to receive the charge. Stressors are coupled to the cabinet and positioned for operation to create a conditioned charge in the flask. An output system is coupled to the flask and includes a receiver for the conditioned charge. The apparatus includes an automated control system operable upon closing the door to lock the door and to then condition the charge, and to then cause the charge to move from the flask to the receiver.Type: GrantFiled: December 6, 2005Date of Patent: July 31, 2007Assignee: Vasogen Ireland LimitedInventors: Sonya Mongomery, Jeff Dayman, Allen Muirhead, Paul Moore, Taras Worona, Simon Treadwell, Murray Voakes, Thomas Porter, Carlton Chong, Liung Sen Liao, Duncan Newman
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Publication number: 20070166189Abstract: An oxygenator that inhibits or prevents bubbles in blood from exiting through a blood outlet includes an oxygenator part which performs gas exchange on blood and a heat exchanging part which performs heat exchange on the blood. The oxygenators part has a housing that is generally in a rectangular parallelepiped form, with a hollow fiber membrane bundle positioned in the housing. The hollow fiber membrane bundle is formed by a multiplicity of hollow fiber membranes adapted to perform gas exchange. Blood flows along a blood passage comprised of gaps between the hollow fiber membranes and contacts the surface of the hollow fiber membranes where gas exchange occurs with gas flowing through the lumens of the hollow fiber membranes. In addition, a filter member is arranged on a downstream side of the hollow fiber membrane bundle so that bubbles present in the blood are caught by the filter member.Type: ApplicationFiled: January 18, 2007Publication date: July 19, 2007Applicant: Terumo Kabushiki KaishaInventor: Mitsuaki Ogihara
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Patent number: 7238320Abstract: A device for oxygenating blood in an extracorporeal circuit includes a first structure suitable to delimit a portion of space-containing capillaries made of microporous membrane. The capillaries convey oxygen and are wet externally by blood flowing through a portion of space between an intake connector, which is connected to a venous line of the extracorporeal circuit, and a delivery connector. The device includes a second structure monolithically connected and contiguous to the first structure. The second structure is suitable to contain blood filtration means that divide the portion of space delimited thereby into a blood distribution chamber, provided with an air vent and connected to the delivery connector of the first structure, and a blood collection chamber provided with a delivery connector connected to the arterial line of the extracorporeal circuit.Type: GrantFiled: March 19, 2004Date of Patent: July 3, 2007Assignee: Sorin Group Italia S.r.l.Inventors: Nicola Ghelli, Edgardo Costa Maianti, Ivo Panzani
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Patent number: 7220236Abstract: The invention provides a method for eliminating HIV in human blood and a device for treating AIDS with non-pharmacotherapy. The method includes (1) pumping the blood containing HIV virus into a soft thin plastic tube while adding air through a T-tube at a definite frequency so that the blood is evenly divided into very small blood droplets (2) introducing the small blood droplets into a screw-shaped quartz tube and exposing the quartz tube under a definite dosage of radiation to kill the HIV virus in the blood droplets is (3) collecting the treated blood in a storage bottle. Results show that after the HIV infected blood is divided into very small blood droplets and is irradiated with a definite dosage of ultraviolet (253.7 nm) for 90 seconds, more than 92% HIV loads in the blood is eliminated, while the lymphocyte (CD4+), erythrocyte, leucocyte and haemoglobin remain almost unchanged.Type: GrantFiled: July 19, 2002Date of Patent: May 22, 2007Assignee: Research Center for Eco-Environmental Sciences, The Chinese Academy of SciencesInventor: Gang Pan
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Patent number: 7198751Abstract: A disposable, integrated extracorporeal blood circuit employed during cardiopulmonary bypass surgery performs gas exchange, heat transfer, and microemboli filtering functions in a way as to conserve volume, to reduce setup and change out times, to eliminate a venous blood reservoir, and to substantially reduce blood-air interface. Blood from the patient or prime solution is routed through an air removal device that is equipped with air sensors for detection of air. An active air removal controller removes detected air from blood in the air removal device. A disposable circuit support module is used to mount the components of the disposable, integrated extracorporeal blood circuit in close proximity and in a desirable spatial relationship to optimize priming and use of the disposable, integrated extracorporeal blood circuit. A reusable circuit holder supports the disposable circuit support module in relation to a prime solution source, the active air removal controller and other components.Type: GrantFiled: December 22, 2003Date of Patent: April 3, 2007Assignee: Medtronic, Inc.Inventors: Walter L. Carpenter, Robert W. Olsen, Stefanie Heine, Frederick A. Shorey, Jr., Laura A. Yonce
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Patent number: 7189352Abstract: A disposable, integrated extracorporeal blood circuit employed during cardiopulmonary bypass surgery performs gas exchange, heat transfer, and microemboli filtering functions in a way as to conserve volume, to reduce setup and change out times, to eliminate a venous blood reservoir, and to substantially reduce blood-air interface. Blood from the patient or prime solution is routed through an air removal device that is equipped with air sensors for detection of air. An active air removal controller removes detected air from blood in the air removal device. A disposable circuit support module is used to mount the components of the disposable, integrated extracorporeal blood circuit in close proximity and in a desirable spatial relationship to optimize priming and use of the disposable, integrated extracorporeal blood circuit. A reusable circuit holder supports the disposable circuit support module in relation to a prime solution source, the active air removal controller and other components.Type: GrantFiled: December 22, 2003Date of Patent: March 13, 2007Assignee: Medtronic, Inc.Inventors: Walter L. Carpenter, Robert W. Olsen, Frederick A. Shorey, Jr., Mark G. Bearss, Bruce R. Jones, Laura A. Yonce
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Patent number: 7172727Abstract: An apparatus and method for blood oxygenation are provided. The apparatus includes a chamber having a first inlet to receive a fluid, e.g., physiologic saline; a second inlet to receive a gas, e.g., oxygen, from a gas supply; and an outlet coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet creates within the chamber fine droplets of fluid into which the gas diffuses to create a gas-supersaturated fluid, which is removed via the outlet. The removed gas-supersaturated fluid mixes with blood within a liquid-to-liquid oxygenation assembly to form oxygenated blood for delivery to a patient. Alternately, the blood may be provided by a pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen diffuses across the membrane(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site.Type: GrantFiled: September 29, 2004Date of Patent: February 6, 2007Assignee: TherOx, Inc.Inventors: William R. Patterson, Stephen E. Myrick, Vincent Divino, Jr., Jeffrey L. Creech, Mark S. Buhr
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Patent number: 7129082Abstract: The invention provides a bio-reactor device and a method of cultivating live cells. The device comprises a holder which contains a matrix of porous foam material in whose interior live cells are anchored, the device comprising also a liquid contained in the holder. The liquid is an oxygen carrier and saturates the matrix, the liquid comprising a synthetic or semi-synthetic constituent. The method involves perfusing the oxygen carrier liquid through the matrix to deliver oxygen to the cells and to absorb carbo-dioxide from the cells.Type: GrantFiled: August 27, 2001Date of Patent: October 31, 2006Assignee: CSIRInventors: Schalk Van Der Merwe, Francis Sean Moolman, Robert Paul Bond, Adriaan Jacobus Van Wyk
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Patent number: 7128873Abstract: An apparatus for conditioning mammalian blood for subsequent use in a medical procedure includes a cabinet having a secure environment and a door providing the only access to the environment. An input system transports a blood charge from a source to the cabinet and a flask is removably contained in the secure environment and coupled to the charge input system to receive the charge. Stressors are coupled to the cabinet and positioned for operation to create a conditioned charge in the flask. An output system is coupled to the flask and includes a receiver for the conditioned charge. The apparatus includes an automated control system operable upon closing the door to lock the door and to then condition the charge, and to then cause the charge to move from the flask to the receiver.Type: GrantFiled: April 20, 2004Date of Patent: October 31, 2006Assignee: Vasogen Ireland LimitedInventors: Sonya Mongomery, Jeff Dayman, Allen Muirhead, Paul Moore, Taras Worona, Simon Treadwell, Murray Voakes, Thomas Porter, Carlton Chong, Liung Sen Liao, Duncan Newman
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Patent number: 7022284Abstract: Apparatus for oxygenating and pumping blood includes a housing defining a blood flow path including, in series, a gas collection plenum, a pump space and a blood oxygenation element. A pump disposed in the pump space is configured to draw blood from the gas collection plenum and propel blood from the pump space through a heat exchanger and the blood oxygenation element. The heat exchanger includes a heat exchange plate and a coolant space.Type: GrantFiled: May 9, 2003Date of Patent: April 4, 2006Assignee: Cardiovention, Inc.Inventors: Ben F. Brian, John Thomas Buckley, Jean-Pierre Dueri, Mehrdad Farhangnia, Steven K. Stringer
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Patent number: 7004926Abstract: An apparatus for automatically retroperfusing a coronary vein includes an intraluminal cannula having a main body portion extending between a proximal end portion and a distal end portion. The proximal end portion is for connecting to an artery outside of the pericardium to automatically supply oxygenated blood from the artery for retroperfusion. The main body portion and the distal end portion are insertable through a vein that is fluidly connected with the coronary vein and into the coronary vein. An expandable stent is attached to the distal end portion for expanding radially into engagement with the interior wall of the coronary vein to secure the distal end portion at a desired location within the coronary vein. Occluding structure for at least partially occluding the coronary vein is provided at the distal end to decrease the back-flow of blood into the right atrium during retroperfusion. The cannula includes passages that allow a limited amount of blood to bypass the occluding structure.Type: GrantFiled: September 10, 2004Date of Patent: February 28, 2006Assignee: Cleveland Clinic FoundationInventors: Jose Luis Navia, Jose Antonio Navia, Jorge Luis Jordana
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Patent number: 6998093Abstract: A fluid oxygenating apparatus is provided which includes a housing defining a chamber, a core positioned within the chamber including a fluid channel formed therein, and a bubble release port communicating with the outlet end of the channel. Fluid is flowed through an inlet of the channel and bubbles are released through the bubble release port. A method and system for debubbling a fluid in such an apparatus is also provided.Type: GrantFiled: April 27, 2000Date of Patent: February 14, 2006Assignee: Medtronic, Inc.Inventors: Kevin D. McIntosh, Bruce R. Jones
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Patent number: 6979423Abstract: A method and system for performing a cardiopulmonary bypass procedure are provided. The method includes accessing a source of blood in a patient body from which source the blood is to be passed through a cardiopulmonary bypass machine, drawing blood from the source through the cardiopulmonary bypass machine and introducing the blood into an aortic artery of the patient body through a plurality of separate passages, after the blood has been passed through the cardiopulmonary bypass machine. The system includes a cardiopulmonary bypass machine, a tubular member coupled to an outlet port of the cardiopulmonary bypass machine and a plurality of separate needle members connected in fluid flow communication with the tubular member, the needle members being arranged to be connected in fluid flow communication with an aortic artery, during a cardiopulmonary bypass procedure.Type: GrantFiled: February 24, 2003Date of Patent: December 27, 2005Assignee: Intuitive SurgicalInventor: Frederic H. Moll
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Patent number: 6974434Abstract: An endovascular system for arresting a patient's heart and maintaining the patient on cardiopulmonary bypass. A venous cannula, venting catheter and an aortic occlusion device are all coupled together so that the blood drawn into each of these catheters may be fed to a pump. A manifold has valves which control flows through the venous cannula, venting catheter and aortic occlusion device. A blood storage element is also provided so that the amount of blood in the perfusion circuit may be varied if necessary. The blood storage element is preferably positioned in parallel with the pump so that the pump may be used to add and remove blood to and from the blood storage element.Type: GrantFiled: July 11, 2002Date of Patent: December 13, 2005Assignee: Heartport, Inc.Inventors: Craig P. Roberts, John M. Toomasian, Sylvia W. Fan
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Patent number: 6967003Abstract: A membrane artificial lung performs gas exchange between blood and a gas via the membrane by flowing the blood in one side of the membrane and flowing oxygen or an oxygen-containing gas in the other side of the membrane. The membrane has a hollow fiber membrane of poly-4-methylpentene-1 and an oxygen permeation rate Q(O2) at 25° C. of from 1×10?6 to 3×10?3 (cm3(STP)/cm2·sec·cmHg) and an ethanol flux of from 0.1 to 100 ml/min·m2. The membrane has, in the side of the blood flow, a surface having an ionic complex derived from: quaternary aliphatic alkylammonium salts; and heparin or a heparin derivative. The quaternary alkylammonium salts are a quaternary aliphatic alkylammonium salt having from 22 to 26 carbon atoms in total and a quaternary aliphatic alkylammonium salt having from 37 to 40 carbon atoms in total.Type: GrantFiled: September 28, 2001Date of Patent: November 22, 2005Assignees: Dainippon Ink and Chemicals, Inc., Toyo Boseki Kabushiki KaishaInventors: Toru Takehisa, Kazunari Sakai, Susumu Kashiwabara, Hidenori Tanaka, Masaki Satoh, Hisateru Takano, Yoshiyuki Taenaka, Eisuke Tatsumi, Tomohiro Nishinaka
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Patent number: 6960322Abstract: Apparatus and methods for pumping and oxygenating blood are provided that include a gas removal system. An integrated blood processing unit is provided in which a gas removal/blood filter, pump and blood oxygenation element are mounted within a common housing. The gas removal system includes a sensor mounted on the housing to sense the presence of gas, and a valve is operably coupled to the sensor to evacuate gas from the system when the sensor detects an accumulation of gas.Type: GrantFiled: July 8, 2003Date of Patent: November 1, 2005Assignee: Cardiovention, Inc.Inventors: Steven K. Stringer, Kevin L. Hultquist, Mehrdad Farhangnia, Ben F. Brian, III, Fred I. Linker, James M. Culp, Jean-Pierre Dueri, Thomas A. Afzal
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Patent number: 6949220Abstract: An integrated, artificial heart-lung machine and method for performing extracorporeal blood oxygenation and circulation. The heart-lung machine is a single unit in which a cylindrical artificial lung, preferably with a heat exchanger, is connected in series to an undulation pump and a removable drive unit. The undulation pump is directly connected to the oxygenator which significantly reduces the blood priming volume of the system.Type: GrantFiled: November 5, 2003Date of Patent: September 27, 2005Inventor: Yusuke Abe
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Patent number: 6946099Abstract: A total condensed circuit for cardiopulmonary bypass and cardioplegia are provided, as well as methods of using the same. The total circuit includes a cardiopulmonary bypass portion including tubing and components which together have a substantially short path length and priming volume preferably under 800 ml. Thus, the opportunity for an inflammatory response caused by blood contacting plasticizers is minimized. The bypass circuit includes a shunt which bypasses a blood reservoir of the total circuit. The cardioplegia circuit infuses cardioplegia fluid into blood pulled from an oxygenator of the bypass circuit. According to the method, either or both of heart-lung bypass and cardioplegia can be performed with only minimal or no isotonic priming solution circulated into the patient. In addition, use of the shunt and reservoir together eliminate the possibility of air entering the circulation system upon kinking of the circuit.Type: GrantFiled: March 31, 2003Date of Patent: September 20, 2005Inventors: Venkataramana Vijay, Kevin McCusker
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Patent number: 6936222Abstract: A compliant blood gas exchanger is provided including a housing having a first end cap, a second end cap, and an elastomeric sidewall or sleeve extending there between forming a chamber. A hollow fiber assembly is disposed in the chamber. The hollow fiber assembly has a first mounting collar, a second mounting collar and a plurality of hollow fibers disposed there between. The first end cap is disposed in communication with the first mounting collar and the second end cap is disposed in communication with the second mounting collar. The end caps are connected to a gas inlet and a gas outlet. The chamber is in communication with a blood inlet and a blood outlet. The elastomeric sidewall is responsive to internal and external pressures affecting the chamber. The first chamber can also be placed adjacent to a second chamber and both chambers placed within a rigid outer housing. Thus, a dual-chamber pulsatile blood gas exchanger can be provided.Type: GrantFiled: September 13, 2002Date of Patent: August 30, 2005Inventors: J. D Mortensen, Robert N. Schaap, Barry Bagley