Gas Chromatography Patents (Class 422/89)
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Patent number: 8968560Abstract: Methods and related apparatuses and mixtures are described for chromatographic analysis. The described system includes a pressurized source of a mobile phase and a flow path in fluid communication with the pressurized source such that the mobile phase flows through the flow path. The system also includes an injector in fluid communication with the flow path and downstream of the pressurized source, the injector being configured to inject a sample into the flow path. A first column located downstream of the injector, contains a stationary phase, and forms part of the flow path. A first detector is positioned to detect properties of fluid in the flow path at a location downstream of the injector and upstream from the first column. A second detector is positioned to detect properties of fluid in the flow path at a location downstream of the first column.Type: GrantFiled: December 6, 2007Date of Patent: March 3, 2015Assignee: Schlumberger Technology CorporationInventor: William H. Steinecker
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Patent number: 8951471Abstract: Certain embodiments described herein are directed to jet assemblies that include a substantially inert fluid flow path. In some examples, a jet assembly includes a fluid flow path comprising a substantially inert metal in a fluid flow path. Devices and systems using the jet assembly are also described. In other embodiments, a brazeless or weldless jet assembly is provided. In some embodiments, the brazeless jet assembly may include an inert material or coating, e.g., a silica coating, in a fluid flow path.Type: GrantFiled: February 26, 2011Date of Patent: February 10, 2015Assignee: Perkinelmer Health Sciences, Inc.Inventor: Rosario Mannino
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Patent number: 8883508Abstract: In some embodiments, apparatus and systems, as well as methods, may operate to draw a formation fluid sample into a sampling port included in a down hole tool, to vaporize some part of the fluid sample to substantially fill an injection port with a gas phase, to differentiate gas components in the gas phase to provide differentiated gas components along a concentration gradient, to detect the differentiated gas components, and to determine a fingerprint of the differentiated gas components. Other apparatus, systems, and methods are disclosed.Type: GrantFiled: July 9, 2013Date of Patent: November 11, 2014Assignee: Halliburton Energy Services, Inc.Inventors: Christopher M. Jones, Michael T. Pelletier
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Patent number: 8871149Abstract: This invention is related to a gas chromatograph wherein more substitutable modules are foreseen, in particular injector modules and/or detector modules, as well as one embodiment in an oven module. Each module is insertable in a seat of the gas chromatograph mainframe with fast connections of its electronic and pneumatic means to corresponding outlets on said mainframe. Each module has its own heating element.Type: GrantFiled: April 6, 2009Date of Patent: October 28, 2014Assignee: Thermo Fisher Scientific S.p.A.Inventors: Giacinto Zilioli, Stefano Pelagatti, Paolo Magni
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Patent number: 8808629Abstract: The invention relates to a transfer unit for analysis devices, containing a tube-shaped assembly which can be heated by an electric heater in a programmed manner, a tube (6) which is arranged in the sample chamber (18) and into which the end of a gas chromatographic separating column can be inserted at the end of said tube, and means for introducing carrier gas into the tube (6), said transfer unit being characterized in that a temperature sensor (8) is arranged in the ring chamber (5) between the inner wall of the assembly and the evaporator tube (6). The transfer unit can be a sample introduction device for a gas chromatograph having a sample introduction head (18), and the assembly can be a sample introduction chamber in which an evaporator tube is provided, wherein the end of a gas chromatographic separating column can be inserted into the end facing away from the sample introduction head (18).Type: GrantFiled: September 14, 2009Date of Patent: August 19, 2014Assignee: Joint Analytical Systems GmbHInventor: Joachim Gerstel
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Patent number: 8778059Abstract: Methods and related systems are described for improving component separations in chromatography through novel techniques. The improvements in separation is due primarily to the provision of differential acceleration of the components being separated. Various systems and methods for providing differential acceleration are described including: increasing the cross section of the column towards the column outlet, changing the thickness or other composition of stationary phase within the column, and providing a temperature and/or mobile phase velocity gradient along the column.Type: GrantFiled: December 3, 2007Date of Patent: July 15, 2014Assignee: Schlumberger Technology CorporationInventors: William H. Steinecker, Jagdish Shah, Oleg Zhdaneev, Gordon R. Lambertus, Hua Chen
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Patent number: 8771597Abstract: The invention relates to an apparatus for the determination of a concentration of a component to be measured in a gas, comprising a light source, a wavelength selection unit, a measurement cuvette, a reference cuvette arranged in the optical beam path in parallel thereto, at least one light receiver and an evaluation unit which determines the concentration from the signals of the light receiver, wherein the gas to be analyzed is supplied to the measurement cuvette, on the one hand, and, on the other hand, to the reference cuvette via an absorption apparatus which includes a substance which completely absorbs the component to be measured. Further, the component to be measured is H2S and a wavelength selection unit is provided for the selection of an absorption wavelength.Type: GrantFiled: May 15, 2012Date of Patent: July 8, 2014Assignee: SICK AGInventors: Michael Zochbauer, Carsten Rogge, Dominikus Huttner
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Patent number: 8722417Abstract: An apparatus is provided for sensing an analyte in a fluid.Type: GrantFiled: January 20, 2007Date of Patent: May 13, 2014Assignee: Invoy Technologies, L.L.C.Inventor: Lubna Ahmad
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Patent number: 8695401Abstract: The disclosure describes a substrate with a fluid-handling assembly coupled to the substrate, the fluid-handling assembly including a plurality of fluid-handling components removably coupled to the substrate and removably coupled to each other. The plurality of fluid handling components includes a gas chromatograph having a fluid inlet and a fluid outlet, and a detector array having a fluid inlet and a fluid outlet, wherein the fluid inlet of the detector array is fluidly coupled to the fluid outlet of the gas chromatograph. A control circuit is communicatively coupled to at least one of the plurality of fluid-handling components, and a readout circuit communicatively coupled to the detector array and to the control circuit. Other embodiments are disclosed and claimed.Type: GrantFiled: December 20, 2011Date of Patent: April 15, 2014Assignee: TricornTech CorporationInventors: Li-Peng Wang, Chien-Lin Huang, Tsung-Kuan A. Chou
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Patent number: 8642351Abstract: The invention provides improved methods and apparatus for fluid chromatography, and is particularly appropriate to high-pressure liquid chromatography carried out using eluent flow rates less than 1 ?l/minute, for example on nanoflow columns. In both single- and multi-dimensional chromatography systems, especially those comprising trapping media to facilitate injection of relatively large volumes of sample on to nanoflow columns, the on-line addition of a diluting solvent enables stronger eluents and sample solvents to be employed without causing premature release of analytes from the trapping media or the degradation of the second dimension chromatographic separation. The invention may be advantageously used for two-dimension reverse phase/reverse phase separations, especially for the separation of complex mixtures of peptides.Type: GrantFiled: September 17, 2007Date of Patent: February 4, 2014Assignee: Waters Technologies CorporationInventors: Hongji Liu, Jeffrey W. Finch
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Patent number: 8641882Abstract: Described is a capillary column cartridge. The cartridge can be used to perform separations according to various techniques such as capillary gas chromatography, capillary electrophoresis and capillary liquid chromatography. The cartridge includes a capillary column secured in a cartridge body. The capillary column includes an inlet port and an outlet port that, in some embodiments, are disposed on a planar surface of the body. When the body is engaged to a separation system module, the inlet port is aligned to receive a sample to be separated and the outlet port is aligned to provide the separated sample to the separation system module. The path of the capillary through the body has a non-planar path shape such as a coil shape. Consequently, longer column lengths can be accommodated, leading to an improvement in separation resolution. The body can include a material having a high thermal conductivity to achieve improved thermal performance.Type: GrantFiled: June 20, 2011Date of Patent: February 4, 2014Assignee: Waters Technologies CorporationInventors: Joseph A. Jarrell, Keith Edward Fadgen
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Publication number: 20140030818Abstract: In a method for performing a solid-phase micro-extraction, a holding device connected to an extraction device and secured on an adapter is held, while an actuating device connected to a guide device is moved. A device for performing a solid-phase microextraction comprises an actuating device connected to a guide device, and a holding device connected to an extraction device, wherein the extraction device is guided at least partially in the guide device, and wherein the extraction device is movable relative to the guide device by means of an actuation of the actuating device.Type: ApplicationFiled: July 29, 2013Publication date: January 30, 2014Applicant: CTC Analytics AGInventors: Kai Heinrich SCHUELER, Melchior ZUMBACH
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Patent number: 8636957Abstract: The present disclosure relates to a spirally wrapped chromatographic structure, a system incorporating such structure and a method of providing such structure. The structure may include an absorber layer having a first surface and a second surface, wherein one or a plurality of channels are defined in the first surface. The structure may also include a support layer having a first surface and a second surface, the first surface of the support layer disposed on the second surface of the absorber layer, wherein the absorber layer and the support layer comprise a spiral configuration such that at least a portion of the first surface of the absorber layer contacts at least a portion of the second surface of the support layer.Type: GrantFiled: May 7, 2009Date of Patent: January 28, 2014Assignee: Southwest Research InstituteInventors: Stephen Thomas Wellinghoff, Kent Edward Coulter
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Publication number: 20140024129Abstract: A system for determining the content of sulfur in a first fluid mixture includes a gas chromatograph including a sample valve, a first column coupled to the sample valve, and a second column coupled to the sample valve. In addition, the system includes a pyrolizer configured to subject the first fluid mixture to pyrolysis to produce a second fluid mixture that includes hydrogen sulfide. The first column is configured to separate at least a first constituent of the second fluid mixture from the hydrogen sulfide in the second fluid mixture and output a third fluid mixture including the hydrogen sulfide. The second column is configured to separate at least a second constituent in the third fluid mixture from the hydrogen sulfide in the third fluid mixture and output a fourth fluid mixture including the hydrogen sulfide. Further, the system includes a detector in fluid communication with the second column.Type: ApplicationFiled: July 20, 2012Publication date: January 23, 2014Applicant: CAMERON INTERNATIONAL CORPORATIONInventors: Shirley Ann Meyer, Randy James Meyer, Stevie Horton Smith
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Publication number: 20140017130Abstract: A sensor for high explosives, comprising a thin layer of fluorescent polymer covalently linked to a silica support with an oxide surface. The support preferably is a silica support, and in a preferred embodiment is a silica chromatographic support. In preferred embodiments, the fluorescent polymer is one or a few monolayers. A preferred embodiment sensor for high explosives is fluorescent polymer within or upon a porous nanostructure. In preferred embodiments the nanostructure is a porous silica nanoparticle. Embodiments of the invention provide methods, sensors, sensor kits, and sensor fabrication processes that enable detecting traces of high explosives by fluorescence quenching in combination with a chromatographic separation. A method for forming a sensor for high explosives includes preparing a fluorescent polymer, capping the reactive polymer with a reactive capping group that covalently reacts with hydroxide groups, and reacting the reactive capping group with surface hydroxides of an oxide support.Type: ApplicationFiled: March 21, 2012Publication date: January 16, 2014Applicant: The Regents of the University of CaliforniaInventors: William C. Trogler, H. Paul Martinez
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Patent number: 8623279Abstract: Ionic liquid (IL)-mediated sol-gel hybrid organic-inorganic materials present enormous potential for effective use in analytical microextraction. One obstacle to materializing this prospect arises from high viscosity of ILs significantly slowing down sol-gel reactions. A method was developed which provides phosphonium-based, pyridinium-based, and imidazolium-based IL-mediated advanced sol-gel organic-inorganic hybrid materials for capillary microextraction. Scanning electron microscopy results demonstrate that ILs can serve as porogenic agents in sol-gel reactions. IL-mediated sol-gel coatings prepared with silanol-terminated polymers provided up to 28 times higher extractions compared to analogous sol-gel coatings prepared without any IL in the sol solution.Type: GrantFiled: November 21, 2011Date of Patent: January 7, 2014Assignee: University of South FloridaInventors: Abdul Malik, Anne M. Shearrow
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Publication number: 20130316388Abstract: This invention relates to an apparatus and a process for rapid, high-throughput analysis of fatty acids in a plurality of samples. The apparatus comprises at least one multi-vessel plate, wherein each vessel is a unit for holding a sample, or mixing and/or reacting a sample with one or more solvents or reagents; at least one matching multi-cap mat capable of sealing the vessels of the multi-vessel plate during the holding, mixing and/or reacting the sample; at least one multi-vessel plate holder having sealing units, whereby the multi-vessel plate holder, when the sealing units are engaged, presses the matching multi-cap mat onto the tops of the vessels in the multi-vessel plate sealing the vessels, so as to withstand high pressure and high temperature conditions. The process employs the apparatus that enables automated, high-throughput analysis of twenty-four fatty acid from a plurality of samples by gas chromatography flame ionization detection.Type: ApplicationFiled: March 14, 2013Publication date: November 28, 2013Applicant: HEALTH DIAGNOSTIC LABORATORY, INC.Inventors: James BOROWSKI, Alexandra SHERMAN, Jennifer WARD, Joseph P. McCONNELL
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Patent number: 8592222Abstract: A method for analyzing molecular pollutants of a fluid. From a calibrated flow of fluid, a combination of a measurement of a total amount of molecular pollutants and a determination of chemical compositions and relative amounts of the molecular pollutants by adsorption on materials is carried out. The determination of the chemical compositions and relative amounts advantageously occur after a threshold value for the total measured amount is exceeded.Type: GrantFiled: October 9, 2009Date of Patent: November 26, 2013Assignee: Commissariat a l'Energie Atomique et aux Energies AlternativesInventor: Isabelle Tovena-Pecault
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Patent number: 8592220Abstract: The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of reactor vessels for containing individual library members, a fluid handling system that apportions a test fluid about equally between each of the vessels and a housing for enclosing the reactor vessels, the housing defining a pressure chamber, wherein the housing is configured to sustain a pressure substantially above atmospheric pressure. This allows for simultaneous screening of library members at high pressure by providing a small pressure differential on reactor components. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants.Type: GrantFiled: October 26, 2007Date of Patent: November 26, 2013Assignee: Intermolecular, Inc.Inventors: H. Sam Bergh, Jason Wells, Victor Wong, John Gallipeo, Lynn Van Erden, Anthony F. Volpe, Jeffrey Maag
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Patent number: 8591814Abstract: Equipment for analyzing a fluid selected from a hydrocarbon fluid, a refinery feedstock, a refinery intermediate, a product of a refinery process, or a component or reaction product thereof, having a portable apparatus containing at least two different analytical devices, each device being able to analyze the fluid. A sample plate is provided in association with the portable apparatus which has a receiver for a fluid to be analyzed, at least two fluidic channels, at least one sensor capable of responding to a physical or chemical property of the fluid, and/or at least one sample cell, and at least one additional fluidic channel for transferring a portion of the fluid or a component or reaction product thereof from the receiver to the at least one sensor and/or sample cell.Type: GrantFiled: January 17, 2007Date of Patent: November 26, 2013Assignee: BP Oil International LimitedInventor: Michael Graham Hodges
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Patent number: 8569070Abstract: A fitting assembly having a nut, a ferrule, and a ferrule tip that may be assembled by an operator. The fitting assembly includes a nut with first and second ends, with the second end adapted to receive the first end of a ferrule, and a ferrule tip with a first end having an externally tapered portion adapted to abut the second end of the ferrule and a second end adapted to be received in a component or fitting of a liquid chromatography system. The nut, ferrule and ferrule tip of the fitting assembly have passageways therethrough for receiving and removably holding tubing.Type: GrantFiled: July 16, 2010Date of Patent: October 29, 2013Assignee: IDEX Health & Science LLCInventors: Scott J. Ellis, Eric Beemer, Nathaniel Nienhuis, Craig W. Graham, Troy N. Sanders
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Publication number: 20130259750Abstract: A chromatographic method including chromatographically separating sample ionic species in an eluent stream, detecting the separated sample ionic species, catalytically combining hydrogen and oxygen gases or catalytically decomposing hydrogen peroxide in a catalytic gas elimination chamber, and recycling the effluent stream from the chamber to the chromatography separation column. The residence time between the detector and the chamber is at least about one minute. Also, flowing the recycle sequentially through two detector effluent flow channels of an electrolytic membrane suppressor. Also, applying heat or UV energy between the detector and the chamber. Also, detecting bubbles after the chamber. Also, a Platinum group metal catalyst and ion exchange medium in the chamber. Apparatus for performing the methods.Type: ApplicationFiled: May 30, 2013Publication date: October 3, 2013Inventors: Yan LIU, Kannan SRINIVASAN, Christopher A. POHL, Sheetal BHARDWAJ, Zhongqing LU
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Patent number: 8492152Abstract: Apparatus and systems, as well as methods, may operate to draw a formation fluid sample into a sampling port included in a down hole tool or tool body, to vaporize some part of the fluid sample to substantially fill an injection port with a gas phase, to differentiate gas components in the gas phase to provide differentiated gas components along a concentration gradient in a receiving section, to detect the differentiated gas components with a detector, and to determine a fingerprint of the differentiated gas components. A reaction section and a vacuum section may be used for waste consumption and/or absorption.Type: GrantFiled: January 10, 2013Date of Patent: July 23, 2013Assignee: Halliburton Energy Services, Inc.Inventors: Christopher M. Jones, Michael T. Pelletier
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Patent number: 8470248Abstract: A detector detects the color of a medium after a gas to be identified and a reagent have chemically reacted with each other on the medium. A controller identifies color information, which is most similar to the color detected by the detector, from color information stored in a spectral database, and reads gas identifying information related to the identified color information, as gas identifying information representing the gas to be identified, from the spectral database.Type: GrantFiled: July 6, 2006Date of Patent: June 25, 2013Assignee: NEC CorporationInventor: Naoki Oda
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Patent number: 8414832Abstract: The invention is a chromatography apparatus which comprises at least one capillary column, which has a coil assembly of column material and a small diameter wire coated with an electrically insulating high temperature material encased within a high temperature sheath. The small diameter wire is at least one electrically conductive element co-linear with the column material. Also provided is means for directly resistively heating the at least one capillary column, and means for controlling the temperature of the capillary column. Additionally, the apparatus includes an oxygen gas containing inlet, a hydrogen inlet, an analyte port and a flame region, oxygen delivery means for delivering oxygen through the oxygen inlet to the flame region, a hydrogen and analyte delivery system for delivering hydrogen and analyte to the flame region, and a detector arranged to detect flame emission.Type: GrantFiled: September 8, 2009Date of Patent: April 9, 2013Inventors: Ned Roques, John Crandall
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Patent number: 8408044Abstract: Automated systems and methods for processing liquid test samples are generally provided. Automated systems generally include a gas and liquid separator configured for removing at least one volatile component from the test sample, a first trapping vessel in fluid communication with the gas and liquid separator, wherein the first trapping vessel contains a trapping material capable of adsorbing at least one of the at least one volatile component to provide at least one adsorbed component, and a heat source configured to heat the trapping material to a temperature sufficient to release at least one of the at least one adsorbed component from the trapping material to provide at least one released component.Type: GrantFiled: June 29, 2009Date of Patent: April 2, 2013Assignee: Brooks Rand IncInventor: Paul Danilchik
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Patent number: 8409510Abstract: In the invention, a collection device includes a flow through micro scale plate arranged to collect analyte. The plate includes holes, and sorbent coating on contact surfaces of the plate. The holes pass analyte fluid flow, for example analyte vapor so that fluid flow for collection may be generally perpendicular to the sorbent plate. Preferred embodiment plates include an integrated heater trace. In preferred embodiments, a high substantially perpendicular flow is used for collection and concentration, and during desorption and delivery a low substantially parallel flow is used. The low flow is selected to meet constraints of a detector system.Type: GrantFiled: October 2, 2006Date of Patent: April 2, 2013Assignees: The United States of America as represented by the Secretary of the Navy, University of Louisville Research Foundation, Inc.Inventors: Robert Andrew McGill, Michael Martin, Mark Crain, Kevin Walsh, Eric Houser, Stanley Vincent Stepnowski, Viet Nguyen
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Patent number: 8404185Abstract: A system for pre-concentrating analytes in a sample prior to introduction into a chromatographic column is generally disclosed comprising a housing, an adsorbent disposed in the housing, and first and second conduits having an inlet and an outlet, respectively, for transferring fluid out of and into the housing during adsorption/dry purge and desorption stages, respectively. In some embodiments, the inlet of the first conduit and the outlet of the second conduit are both disposed in one end of the housing and are offset from each other with respect to the adsorbent.Type: GrantFiled: April 20, 2006Date of Patent: March 26, 2013Assignee: PerkinElmer Health Sciences, Inc.Inventors: Andrew Tipler, Richard G Edwards, James E. Botelho
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Publication number: 20130058830Abstract: The present application provides a method for determining one or two parameters of a sensor system for detecting a gaseous sample. The sensor system comprises a light source to generate a light beam, a hollow waveguide to receive the light beam and the gaseous sample, and a detector to detect an absorption peak of the gaseous sample, where the length and inner diameter of the hollow waveguide satisfy relationships as disclosed herein.Type: ApplicationFiled: November 5, 2012Publication date: March 7, 2013Applicant: GEOISOCHEM CORPORATIONInventor: GEOISOCHEM CORPORATION
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Patent number: 8389289Abstract: A gas chromatograph (GC) apparatus capable of detecting abnormality, in which a reference retention index is obtained from a result obtained by analyzing a given substance and a retention-index reference substance under adequate analysis conditions using a normal column, and stored in a storage section. Further, under a condition that the apparatus can perform normal analysis, the given substance is subjected to GC analysis to obtain a reference retention time, and the obtained reference retention time is stored in the storage section. A diagnosis processing section is operable to compare each of an actual retention time and an actual retention index with a respective one of the reference retention time and the reference retention index. If a deviation therebetween or abnormality is detected, the diagnosis processing section is operable to estimate a causal factor of the abnormality.Type: GrantFiled: September 10, 2009Date of Patent: March 5, 2013Assignee: Shimadzu CorporationInventor: Shuichi Kawana
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Publication number: 20120329166Abstract: A flow regulating system for maintaining a stable air flow comprising at least one pump, a mass flow sensor, an ambient temperature sensor, an ambient pressure sensor, a temperature compensation sensor measuring the temperature of said mass flow sensor, and a control system is disclosed, as well as a method for measuring a flow using said flow regulating system, a device for the monitoring of air-borne compounds present in air in both a gas phase and a particle phase, wherein it comprises a sampling device, an enrichment trap 1, a calibration and tuning module, a blank module, said flow regulating system, a chromatography unit, and a detection unit, and a method for the detection of air-born compounds in an air flow by using said monitoring device.Type: ApplicationFiled: March 1, 2011Publication date: December 27, 2012Inventors: Gunnar Skarping, Marianne Dalene
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Patent number: 8323488Abstract: Embodiments in accordance with the present invention relate to packed-column nano-liquid chromatography (nano-LC) systems integrated on-chip, and methods for producing and using same. The microfabricated chip includes a column, flits/filters, an injector, and a detector, fabricated in a process compatible with those conventionally utilized to form integrated circuits. The column can be packed with supports for various different stationary phases to allow performance of different forms of nano-LC, including but not limited to reversed-phase, normal-phase, adsorption, size-exclusion, affinity, and ion chromatography. A cross-channel injector injects a nanolitre/picolitre-volume sample plug at the column inlet. An electrochemical/conductivity sensor integrated at the column outlet measures separation signals.Type: GrantFiled: February 28, 2011Date of Patent: December 4, 2012Assignees: California Institute of Technology, City of HopeInventors: Yu-Chong Tai, Qing He, Jun Xie, Changlin Pang, Terry D. Lee, Damien Rodger, Matthieu Liger
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Patent number: 8323575Abstract: A method includes compressing chemical-analysis data points with no loss of information, generating, from the stored data points, nested data arrays, storing the nested data arrays in a video memory, rendering an image from the nested data arrays, and displaying the rendered image. A chemical-analysis instrument includes a chromatography module, a mass-spectrometry module that receives an eluent from the chromatography module, a computer unit that receives data points from the chromatography and mass-spectrometry modules, and a monitor for displaying rendered images.Type: GrantFiled: May 12, 2006Date of Patent: December 4, 2012Assignee: Waters Technologies CorporationInventor: Jose Luis deCorral
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Patent number: 8298488Abstract: A microfabricated TID comprises a microhotplate and a thermionic source disposed on the microhotplate. The microfabricated TID can provide high sensitivity and selectivity to nitrogen- and phosphorous-containing compounds and other compounds containing electronegative function groups. The microfabricated TID can be microfabricated with semiconductor-based materials. The microfabricated TID can be combined with a microfabricated separation column and used in microanalytical system for the rapid on-site detection of pesticides, chemical warfare agents, explosives, pharmaceuticals, and other organic compounds that contain nitrogen or phosphorus.Type: GrantFiled: November 4, 2004Date of Patent: October 30, 2012Assignee: Sandia CorporationInventors: Patrick R. Lewis, Ronald P. Manginell, David R. Wheeler, Daniel E. Trudell
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Publication number: 20120270330Abstract: The present invention provides a device that makes it possible to perform real-time detection and analysis of BTEX components in real samples using an inexpensive and miniaturized hybrid specific binding-separation device. The device may be used in occupational health and safety applications as well as for toxicological population studies to determine the presence of organic volatile components in an air sample.Type: ApplicationFiled: August 25, 2010Publication date: October 25, 2012Applicant: Arizona Board of Regents for and on behalf of Arizona State UniversityInventors: Nongjian Tao, Erica Forzani, Rodrigo A Iglesias, Francis Tsow
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Publication number: 20120263626Abstract: An apparatus, according to one aspect, may include a chromatograph and a bulk acoustic resonator. The chromatograph may include a channel that is defined at least partially in a monolithic substrate. The channel may have an inlet to receive a sample and an outlet. A chromatography material may be included in the channel. The bulk acoustic resonator may have a first electrode and a second electrode that has a chemically functionalized surface. The chemically functionalized surface may be included in a chamber that is defined at least partially in the monolithic substrate and that is coupled with the outlet of the channel. Methods of making and using such apparatus, and systems including such apparatus, are also disclosed.Type: ApplicationFiled: May 4, 2012Publication date: October 18, 2012Inventors: Li-Peng Wang, Qing Ma
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Patent number: 8247239Abstract: A method for introducing standard gas into a sample vessel is generally disclosed comprising providing a vessel containing a sample gas and a receptacle with a vessel port, such as sampling needle, pressurizing the vessel with a carrier gas, and introducing a volume of standard gas into the flow path of the carrier gas being used to pressurize the vessel when the vessel port of the receptacle is located within the vessel. In some embodiments, a rotary valve is loaded with the standard gas, and the valve is brought into fluid communication with the flow path of the carrier gas when the vessel port is within the vessel.Type: GrantFiled: April 13, 2006Date of Patent: August 21, 2012Assignee: PerkinElmer Health Sciences, Inc.Inventors: Andrew Tipler, Christopher Mazza, David J. Scott
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Patent number: 8182768Abstract: A system for interfacing a sampling device and a chromatograph and for pre-concentrating analytes in a sample prior to introducing the sample into the chromatographic column is generally disclosed comprising an interface housing with a first channel and an adsorbent housing with a second channel, which contains at least one adsorbent. Valveless conduits permit fluid to be communicated between the sampling device and the first channel, between the first channel and the second channel, and the first channel and the column. In some embodiments, fluid flows in one direction when the analytes are adsorbed and in the opposite direction when analytes are desorbed. In certain embodiments, two different adsorbents are disposed in the second channel to adsorb different types of analytes.Type: GrantFiled: October 14, 2005Date of Patent: May 22, 2012Assignee: PerkinElmer LAS, Inc.Inventors: Andrew Tipler, John H. Vanderhoef, James E. Botelho
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Patent number: 8178045Abstract: An interchangeable preconcentrator assembly comprises an outer housing and an inner housing defining a chamber. A biased urging member is held at least partially within the outer housing and slidably biased toward a surface of the inner housing. When the biased urging member is at least partially retracted, a space is defined between the urging member and the surface of the inner housing for accommodating at least one preconcentrator chip. A continuous fluid flow path is defined through the outer housing and through the space. The interchangeable preconcentrator assembly may further comprise at least one modular preconcentrator carriage.Type: GrantFiled: December 17, 2008Date of Patent: May 15, 2012Assignee: University of Louisville Research Foundation, Inc.Inventors: Scott Cambron, Thomas Roussel, Robert Keynton, Michael Martin, Kevin Walsh, Doug Jackson, John Naber
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Patent number: 8178047Abstract: An apparatus, according to one aspect, may include a chromatograph and a bulk acoustic resonator. The chromatograph may include a channel that is defined at least partially in a monolithic substrate. The channel may have an inlet to receive a sample and an outlet. A chromatography material may be included in the channel. The bulk acoustic resonator may have a first electrode and a second electrode that has a chemically functionalized surface. The chemically functionalized surface may be included in a chamber that is defined at least partially in the monolithic substrate and that is coupled with the outlet of the channel. Methods of making and using such apparatus, and systems including such apparatus, are also disclosed.Type: GrantFiled: March 30, 2010Date of Patent: May 15, 2012Assignee: Intel CorporationInventors: Li-Peng Wang, Qing Ma
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Patent number: 8149115Abstract: This device will allow individuals to pass through explosive detection portals efficiently without undue delay. The airflow from a series of jets will dislodge embedded molecules and direct them to a sensor that will detect the presence of commonly found explosive materials. The molecules that are dislodged will be accomplished by air flow through an air tunnel or portal structure that is not invasive to the person yet allows real time detection of explosive material while not infringing on the privacy of the individual.Type: GrantFiled: March 26, 2009Date of Patent: April 3, 2012Inventors: Gianni Arcaini, Larry Strach
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Patent number: 8137979Abstract: Improved preconcentrators, particularly MEMs scale preconcentrators which possess a coating comprising polymers of intrinsic microporosity (PIMs). There is further provided devices comprising the preconcentrator, and methods of preparation and use. There is particular benefit directed to the use of a MEMs scale heater coated with the PIMs for use in hand-held or field portable chemical detection devices. The polymer of intrinsic microporosity comprises a polymer, with a monomer repeat unit of Formula I wherein A is one or more optionally substituted aryl, heterocyclic, cycloalkyl or bicycloalkyl rings, ? is greater than 5, preferably 5 to 10000, and X may be selected from CH, CH2, O, S, N or NH.Type: GrantFiled: June 25, 2008Date of Patent: March 20, 2012Assignee: QinetiQ LimitedInventors: David J. Combes, Timothy I Cox, Ian C Sage
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Publication number: 20120017760Abstract: An apparatus and method for rapid fractionation of hydrocarbon phases in a sample fluid stream are disclosed. Examples of the disclosed apparatus and method include an assembly of elements in fluid communication with one another including one or more valves and at least one sorbent chamber for removing certain classifications of hydrocarbons and detecting the remaining fractions using a detector. The respective ratios of hydrocarbons are determined by comparison with a non separated fluid stream.Type: ApplicationFiled: July 21, 2010Publication date: January 26, 2012Applicant: UT-BATTELLE, LLCInventors: Charles S. Sluder, John M. Storey, Samuel A. Lewis, SR.
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Patent number: 8062610Abstract: For analysis of small quatities of target analytes in an environment, the gas flow can be delivered to a suitably fast analyzer and their concentration determined in a time period whose duration is dependent on the analyte, its concentration and the phase separation properties. A device having a sorbent bed that is essentially concentric with a passage way containing thermal fluid is used to concentrate the target analyte.Type: GrantFiled: February 16, 2006Date of Patent: November 22, 2011Assignee: The United States of America as represented by Environmental Protection AgencyInventors: Brian K. Gullett, Abderrahamne Touati, Shawn Ryan, William Squier
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Patent number: 8062905Abstract: A purge and trap concentrator system that includes a sparge vessel, and includes a variable gas flow valve for controlling the gas pressure in an analytic trap or the sparge vessel; a sensor that detects both a foaming sample state and a high liquid level in the sparge vessel, using one optical sensor; a control scheme that re-directs the purge gases to a second inlet of the sparge vessel during a foaming condition; a control scheme that uses a split flow to enhance the quantity of sample gases passed from an analytic trap; an electrically powered thermal energy source with a fan raising the sparge vessel temperature via thermal convection.Type: GrantFiled: May 13, 2011Date of Patent: November 22, 2011Assignee: EST Analytical, Inc.Inventor: Douglas A. Meece
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Patent number: 8043565Abstract: Gas chromatography apparatuses are provided that can include a housing configured to substantially envelop the column within the compartment. Analytical instruments are provided that can include at least one chromatography column compartment having a volume of the less than 100 mL. Analytical methods are provided that can include increasing the temperature of a chromatography column at a rate of about 60° C./minute using less than about 40 W. Methods are also provided that include providing at least one gas chromatography column compartment configured to substantially envelop a gas chromatography column and performing analysis with the one compartment in the first operable position and/or transitioning portions to the second operable position to allow access to the one compartment.Type: GrantFiled: May 12, 2006Date of Patent: October 25, 2011Assignee: Griffin Analytical Technologies, L.L.C.Inventors: Garth E. Patterson, Mark Gregory
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Patent number: 8017081Abstract: A system and method of measuring the effective temperature inside a sealed container having a headspace is provided. A liquid solvent is added to the container, and a solid compound is added to the liquid solvent to create a saturated solution. Vapor of the saturated solution is allowed to equilibrate in the headspace of the sealed container, and a volume thereof is transferred to a chromatographic column, where chromatographic readings of the equilibrated vapor are taken. A temperature within the sealed container is then calculated based upon the chromatographic readings of the equilibrated vapor, wherein the temperature calculation is based upon the concentrations of the liquid solvent and the solid compound in the equilibrated vapor.Type: GrantFiled: October 31, 2008Date of Patent: September 13, 2011Assignee: PerkinElmer Health Sciences, Inc.Inventor: Andrew Tipler
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Patent number: 7976780Abstract: Methods and apparatus are provided to measure isotopic characteristics of a number of sample types. Embodiments of the invention combine novel and existing components to produce more accurate isotopic information. Further, embodiments of the invention allow for isotopic readings to be taken and analyzed outside of a laboratory. An example of such an embodiment is an apparatus comprising a combustion furnace; a reactant tube passing through the combustion furnace; an injector coupled to one, or a combination of, the combustion furnace, and reactant tube, to introduce a sample; a laser isotopic measurement device coupled to the reactant tube on the exit end; and a processor electrically coupled to one, or a combination of, the injector, the combustion furnace, the reactant tube, and the isotopic measurement device, in which a carrier gas transports the sample through the apparatus.Type: GrantFiled: August 15, 2005Date of Patent: July 12, 2011Assignee: Halliburton Energy Services, Inc.Inventors: Louis W. Elrod, Christopher M. Jones
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Patent number: 7964411Abstract: A sample concentrator for concentrating analytes in a solvent-containing liquid sample stream, including concentrator housing having a sample stream flow channel and a gas stream flow channel having an inlet and an outlet, a heater for gas in the gas stream conduit, and a hydrophilic ion exchange or non-ionic membrane barrier separating said gas stream flow channel and said sample stream flow channel. Solvent is evaporated from the liquid sample stream in said sample stream flow channel in or at the interface with said membrane, when the gas stream is at an elevated temperature. A regeneration step is used to regenerate the ion exchange membrane barrier.Type: GrantFiled: June 12, 2007Date of Patent: June 21, 2011Assignees: Dionex Corporation, Board of Regents, The University of TexasInventors: Purnendu Dasgupta, Masaki Takeuchi, Kannan Srinivasan
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Patent number: 7959865Abstract: The invention relates to a miniaturized gas chromatograph and injector for the same. Said micro-GC is compact and simple and economical to construct. Dead volumes are largely avoided in order to achieve reliable and reproducible measured results. Said miniaturized gas chromatograph comprises at least one injector, one separation column and a detector which are combined on a circuit board to give a gas chromatography module. The injector comprises a first sheet with channels, which is provided with a second sheet with channels and which may be displaced relative to the latter, whereby at least one of the sheets is provided with a layer of plastic, in particular a chemically inert plastic on the side of the sheet facing the other side.Type: GrantFiled: January 14, 2004Date of Patent: June 14, 2011Assignee: SLS Micro Technology GmbHInventors: Tobias Schmidt, Mathias Mahnke, Uwe Lehmann