Attached To Carbohydrate Compound; Derivative Thereof (e.g., Dna, Nucleotide, Nucleoside, Sugar, Starch, Tannin, Saccharide, Polysaccharide, Cellulose, O-, N- And S-glycoside, Vitamin B12) Patents (Class 424/1.73)
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Publication number: 20110189088Abstract: The invention provides compounds such as chelating agents useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications.Type: ApplicationFiled: December 23, 2010Publication date: August 4, 2011Applicant: Lumiphore, Inc.Inventors: Jide Xu, Nathaniel G. Butlin, Darren Magda
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Patent number: 7988949Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one antibiotics or equivalent bioactive agent characterized with a positive surface charge and their enhanced permeability in oral drug delivery.Type: GrantFiled: January 27, 2011Date of Patent: August 2, 2011Assignees: GP Medical, Inc., National Tsing Hua UniversityInventors: Hsing-Wen Sung, Hosheng Tu
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Patent number: 7985425Abstract: The present invention is a method for manufacture and treatment of depression and health disorders using a non-pharmacologic stable negative ion solution.Type: GrantFiled: June 13, 2003Date of Patent: July 26, 2011Inventor: Jack V. Smith
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Publication number: 20110176998Abstract: The present invention features compositions and methods for detecting, selecting a treatment method for, monitoring, and treating a neoplasia associated with a viral infection.Type: ApplicationFiled: October 13, 2010Publication date: July 21, 2011Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Martin G. Pomper, Richard Ambinder, Jun O. Liu, Curtis R. Chong, Jianmeng Chen
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Publication number: 20110176997Abstract: The present invention relates a method to make porous materials which are useful in pharmaceutical, medicine, industry, and agriculture. The most advantage of the porous materials is to provide extremely large surface area for further modification and to incorporate a bioactive reagent in a mild condition to make the porous materials bioactive, biocompatible and biodegradable.Type: ApplicationFiled: January 21, 2010Publication date: July 21, 2011Inventor: Zhuo Joe Zhang
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Patent number: 7976824Abstract: The invention relates to a compound of formula (I): wherein P1, P2, P3, and P4 are each independently hydrogen or a protecting group; and n is an integer of from 2 to 20 and to the use of such compounds for the synthesis of 18F-FDG.Type: GrantFiled: July 29, 2004Date of Patent: July 12, 2011Assignee: GE Healthcare LimitedInventors: Lynda Jane Brown, Richard Charles Downie Brown, Harry John Wadsworth, Alexander Jackson
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Publication number: 20110158906Abstract: The present invention provides a micelle comprising an amphiphilic block copolymer, said amphiphilic block copolymer consisting of (a) a hydrophobic polymer attached to the 5? end of a first nucleic acid molecule, wherein said first nucleic acid molecule is hybridized with a second nucleic acid molecule, wherein a targeting unit capable of selectively binding to a specific cell type and/or tissue is attached to the 5? end of said second nucleic acid molecule; and/or (b) a hydrophobic polymer attached to the 3? end of a first nucleic acid molecule, wherein said first nucleic acid molecule is hybridized with a second nucleic acid molecule, wherein a targeting unit capable of selectively binding to a specific cell type and/or tissue is attached to the 3? end of said second nucleic acid molecule.Type: ApplicationFiled: August 13, 2008Publication date: June 30, 2011Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V.Inventors: Klaus Müllen, Fikri E. Alemdaroglu, Andreas Herrmann, N. Ceren Alemdaroglu, Peter Langguth
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Publication number: 20110142756Abstract: The invention features compositions and methods for treating or alleviating a symptom of cancer. The compositions and methods of the invention direct supra-lethal doses of radiation, called Hot-Spots, to virtually all cancer cell types.Type: ApplicationFiled: October 4, 2010Publication date: June 16, 2011Inventors: George L. Mayers, Samuel Rose, David S. Rose
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Publication number: 20110117016Abstract: The Invention relates to conjugates of formula (III) or (IIIa), or a salt thereof, their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes.Type: ApplicationFiled: January 21, 2011Publication date: May 19, 2011Inventors: Magne SOLBAKKEN, Bente ARBO, Alan CUTHBERTSON, Alexander GIBSON
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Publication number: 20110097265Abstract: A test indicator for quantifying remaining liver function is provided. A novel liver receptor imaging agent with liver targeting property is utilized to develop a method for quantifying remaining liver function to serve as test indicator for judging the liver failure outcome in clinic, particularly for judging the necessity of liver transplantation for patients with liver failure or liver disease. The radioactivity uptake of the test indicator was negatively correlated with the extent of liver reserve. The cutoff value of liver reserve for liver transplantation is also disclosed.Type: ApplicationFiled: May 13, 2010Publication date: April 28, 2011Applicant: Institute of Nuclear Energy Research Atomic Energy Council, Executive YuanInventors: Mei-Hui Wang, Wuu-Jyh Lin, Chuan-Yi Chien, Hung-Man Yu, Reiko Takasaka Lee, Yuan-Chuan Lee
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Publication number: 20110097264Abstract: A radiolabeling method using a multivalent glycoligand as hepatic receptor imaging agent is provided. The multivalent glycoligand-DTPA derivatives (In-111-DTPA-hexa lactoside and In-111-DTPA-tri-galactosamine glycoside) labeled with In-111 are used as hepatic receptor imaging agent. The effects of imaging of a hepatic receptor in different species are evaluated, the lowest specific radioactivity values of hepatic receptor imaging required in different species are discovered. Since the specificity of the human ASGPR closely resembles that of the mouse. This kind of radiolabelling method, agent and related study about specific radioactivity could be used in clinical trial in the future.Type: ApplicationFiled: May 13, 2010Publication date: April 28, 2011Applicant: Institute of Nuclear Energy Research Atomic Energy Council, Executive YuanInventors: Mei-Hui Wang, Wuu-Jyh Lin, Chuan-Yi Chien, Hung-Man Yu, Reiko Takasaka Lee, Yuan-Chuan Lee
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Publication number: 20110085969Abstract: Disclosed are methods of imaging a site in a heart of a subject to detect cardiovascular disease that involve stressing a subject, administering to the stressed subject an effective amount of a radionuclide-labeled chelator-glucose analog conjugate, and imaging the heart of the subject by detecting a signal generated by the conjugate in the heart of the subject. Also disclosed are methods of imaging a peripheral blood vessel in a subject by using a detectable amount of a radionuclide-labeled chelator-glucose analog conjugate. Also disclosed are methods of distinguishing a false positive nuclear cardiology scan from a true positive nuclear cardiology scan, methods of diagnosing congestive heart failure or cardiac ischemia that involve imaging a subject that has been administered a radionuclide-labeled chelator-glucose analog conjugate, and methods to distinguish viable from nonviable myocardium.Type: ApplicationFiled: October 7, 2010Publication date: April 14, 2011Inventors: F. David Rollo, Jerry L. Bryant
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Publication number: 20110081293Abstract: Disclosed are compositions and methods related to clot-binding head groups. The disclosed targeting is useful for treatment of cancer and other diseases and disorders.Type: ApplicationFiled: September 30, 2010Publication date: April 7, 2011Applicants: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE, REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: ERKKI RUOSLAHTI, DAVID PETERS, MATTHEW TIRRELL, MARK KASTANTIN
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Patent number: 7919072Abstract: The invention discloses the bioactive nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and enhanced permeability in oral drug delivery.Type: GrantFiled: August 5, 2009Date of Patent: April 5, 2011Assignees: GP Medical, Inc., National Tsing Hua UniversityInventors: Hsing-Wen Sung, Hosheng Tu
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Publication number: 20110070158Abstract: A sample card and automated quality control module for a radiopharmaceutical synthesis system for conducting quality control tests on approximately one (1) unit dose of a radiopharmaceutical biomarker for use in positron emission tomography. The sample card and quality control module allow operators to conduct quality control tests in reduced time using micro-scale test samples from the radiopharmaceutical solution. The sample card works in conjunction with a microfluidic radiopharmaceutical synthesis system to collect samples of radiopharmaceutical solution on the scale of 5-20 microliters per sample. The sample card then interacts with the quality control module to feed the samples into a number of test vessels, where the samples undergo a number of automated quality control tests.Type: ApplicationFiled: September 23, 2009Publication date: March 24, 2011Inventors: Ronald Nutt, Anthony M. Giamis, Aaron McFarland
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Publication number: 20110070159Abstract: Provided is a composition which contains a red microalga polysaccharide and a heavy metal, which is used as a cosmetic, diagnostic, or pharmaceutical formulation. The pharmaceutical formulation may be employed topically or for treating nutritional and other disorders.Type: ApplicationFiled: May 21, 2009Publication date: March 24, 2011Applicant: Ben-Gurion University of the Negev Research and Development AuthorityInventor: Shosh Arad
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Patent number: 7910594Abstract: This invention relates to vitamin-mitomycin conjugates, to a method of using the conjugates to selectively eliminate a population of pathogenic cells in a host animal harboring the pathogenic cells, and to a method of preparation of the conjugates. The conjugate is of the general formula B-L-X wherein the group B is a vitamin, or an analog or a derivative thereof, that binds to a surface accessible vitamin receptor that is uniquely expressed, overexpressed, or preferentially expressed by a population of pathogenic cells, wherein the group L comprises a cleavable linker, and wherein the group X comprises a mitomycin compound, or an analog or a derivative thereof. An additional therapeutic agent, such as a chemotherapeutic agent, can be administered in combination with the conjugate.Type: GrantFiled: May 13, 2003Date of Patent: March 22, 2011Assignee: Endocyte, Inc.Inventors: Iontcho Radoslavov Vlahov, Christopher P. Leamon
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Patent number: 7910086Abstract: The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.Type: GrantFiled: April 21, 2010Date of Patent: March 22, 2011Assignees: GP Medical, Inc., National Tsing Hua UniversityInventors: Hsing-Wen Sung, Hosheng Tu
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Publication number: 20110064659Abstract: Differential expression of nucleic acids in the brains of subjects suffering from late-onset depression has been demonstrated. The invention provides methods useful in the determination of late-onset depression. Also provided by the present invention is a screening method for the identification of compounds for treatment, prevention or diagnosis of late-onset depression.Type: ApplicationFiled: May 15, 2009Publication date: March 17, 2011Inventors: Peter Hanson, Duncan Hiscock, Chris Morris, Alan Thomas
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Patent number: 7906103Abstract: Disclosed are Drug Delivery Molecules (DDMs) which both facilitate functional imaging, as by PET, MRI or SPECT, and create a biological effect and methods of their use. These DDMs which are variously designed to target specific receptors, internalized and then function biologically, as for purposes of cell destruction or therapy.Type: GrantFiled: October 16, 2006Date of Patent: March 15, 2011Inventor: Gerhard Graupner
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Publication number: 20110059014Abstract: Embodiments of the present disclosure provide for compounds and methods of making compounds such as those shown in FIGS. 1.1A and 1.1B having formula 2, 3, 4, 5, 11, and 12 and formula 2?, 4?, and 11?, as well as uses for the compounds for imaging, and the like.Type: ApplicationFiled: September 3, 2010Publication date: March 10, 2011Inventors: Mohammad Namavari, Sanjiv Sam Gambhir, Beverly S. Mitchell
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Patent number: 7901666Abstract: The invention discloses a pharmaceutical composition for treating a subject comprising two or more bioactive nanoparticles, thus treating the subject by co-administering the bioactive nanoparticles to the subject, wherein a first and a second bioactive nanoparticles comprise a shell portion that is dominated by positively charged chitosan, a core portion that contains negatively charged substrate, and at least a first bioactive agent in the first nanoparticle and a second bioactive agent in the second nanoparticle.Type: GrantFiled: June 1, 2009Date of Patent: March 8, 2011Assignees: GP Medical, Inc., National Tsing Hua UniversityInventors: Hsing-Wen Sung, Hosheng Tu
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Patent number: 7888330Abstract: The present invention provides phosphoramidate derivatives of a furanosyluracil analog, FAU, that can effectively deliver FAU monophosphate, or a derivative thereof, intracellularly. FAU-Phosphoramidate diesters can bypass the first step of phosphorylation and be activated intracellularly so as to be converted to nucleoside monophosphates. This results in improved formation of nucleoside triphosphates, and higher incorporation into DNA. The compounds of the invention can be used to treat cancer.Type: GrantFiled: November 9, 2006Date of Patent: February 15, 2011Assignee: Wayne State UniversityInventors: Anthony F. Shields, Jiri Zemlicka, Sridhar Nimmagadda
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Patent number: 7883687Abstract: This invention relates to novel 15O-labeled monosaccharide useful for positron emission tomography (PET) and producing method thereof.Type: GrantFiled: March 28, 2005Date of Patent: February 8, 2011Assignees: Astellas Pharma Inc.Inventors: Eiichi Nakamura, Shintaro Nishimura, Yoshihiro Murakami, Hideki Yorimitsu
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Publication number: 20110027174Abstract: The present invention provides a novel approach to cancer therapy and diagnostics that utilizes nanotubes and other similar nanostructures as both an indirect source of radiation therapy (BNCT), and as delivery vehicles for other types of radio- and chemo-therapeutic materials, as well as imaging agents for diagnostic purposes.Type: ApplicationFiled: October 15, 2010Publication date: February 3, 2011Inventors: Dan A. Buzatu, Jon G. Wilkes, Dwight Miller, Jerry A. Darsey, Tom Heinze, Alex Birls, Richard Beger
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Patent number: 7879312Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one DNA/RNA or bioactive agent characterized with a positive surface charge and their enhanced permeability for gene delivery and bioactive agent delivery.Type: GrantFiled: May 23, 2009Date of Patent: February 1, 2011Assignees: GP Medical, Inc., National Tsing Hua UniversityInventors: Hsing-Wen Sung, Shu-Fen Peng, Hosheng Tu
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Patent number: 7879313Abstract: The invention discloses nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge. The bioactive agent is hydrophobic or lipophilic in nature and is associated with micelles before being encapsulated in nanoparticles.Type: GrantFiled: May 24, 2010Date of Patent: February 1, 2011Assignees: GP Medical, Inc., National Tsing Hua UniversityInventors: Hsing-Wen Sung, Hosheng Tu
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Patent number: 7875291Abstract: A nutritional supplement includes a first formulation including minerals: chromium polynicotinate, magnesium glycinate, manganese sulfate, selenium, vanadyl sulfate, zinc gluconate, copper gluconate, iodine, and boron; and vitamins: vitamins C, B1, B2, B3, B6, B12, and D, biotin, alpha-lipoic acid, and folic acid. The second formulation, packaged separately from the first, includes essential fatty acids: evening primrose oil, flax seed oil, sunflower oil, sesame seed oil, and pumpkin seed oil; and vitamins: vitamin E and vitamin Q-10. A method for improving metabolic function includes consuming the first and second formulation. A method of formulating a composition for improving metabolic function includes packaging together the first formulation and packaging together and separately from the first formulation the second formulation.Type: GrantFiled: January 17, 2008Date of Patent: January 25, 2011Assignee: Glu-Pro, Inc.Inventors: Amid Habib, Samuel E. Crockett, Claude T. Isler, Sam Pratt
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Publication number: 20110002849Abstract: The present invention relates to a method to assist in the determination of therapy for a patient suffering from Barrett's oesophagus, especially where first-line therapy has been unsuccessful and when dysplasia has been diagnosed. The method comprises the use of an imaging agent comprising a vector which targets (a) Her2, (b) cMet, (c) guanylyl cyclase or (d) IGF1R. The imaging agent is suitable for radioisotope or optical imaging in vitro or preferably in vivo.Type: ApplicationFiled: February 26, 2009Publication date: January 6, 2011Inventors: Antonios Danikas, Clifford Smith, Ian A. Wilson
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Patent number: 7862798Abstract: The invention relates to compounds and methods for targeting radionuclide-based imaging agents to cells having receptors for a vitamin, or vitamin receptor binding derivative or analog thereof, by using such a vitamin as the targeting ligand for the imaging agent. The invention provides a compound of the formula for use in such methods. In the compound, V is a vitamin that is a substrate for receptor-mediated transmembrane transport in vivo, or a vitamin receptor binding derivative or analog thereof, L is a divalent linker, R is a side chain of an amino acid of the formula H2NCHRCOOH, M is a cation of a radionuclide, n is 1 or 0, K is 1 or 0, and the compound can be in a pharmaceutically acceptable carrier therefor. The vitamin-based compounds can be used to target radionuclides to cells, such as a variety of tumor cell types, for use in diagnostic imaging of the targeted cells.Type: GrantFiled: October 11, 2006Date of Patent: January 4, 2011Assignee: Endocyte, Inc.Inventors: Christopher P. Leamon, Matthew A. Parker
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Publication number: 20100322858Abstract: We disclose methods of synthesizing radiohalidated organic compounds and their use in positron emission tomography (PET) imaging of cancer cells.Type: ApplicationFiled: August 22, 2007Publication date: December 23, 2010Inventors: William Bornmann, Mian Alauddin, Juri Gelovani, Pradip Ghosh, Liwei Guo, Dongmei Han, David Maxwell, Uday Mukhopadhyay, Zhenghong Peng, Aleksandr Shavrin, Yunming Ying
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Patent number: 7850946Abstract: The sensitivity and specificity of the optical modality can be enhanced by the use of highly absorbing compounds as contrast agents. Novel macrocyclic cyanine and indocyanine bioconjugates that absorb and emit light in the near infrared region of electromagnetic spectrum are disclosed. These compounds are especially useful for endoscopic, localized photoacoustic, and sonofluorescence imaging, detection and therapy of tumors and other abnormalities.Type: GrantFiled: June 1, 2004Date of Patent: December 14, 2010Assignee: Washington University in St. LouisInventors: Samuel Achilefu, Yunpeng Ye
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Publication number: 20100290988Abstract: The present invention is directed to fructose-based radiopharmaceuticals, pharmaceutical compositions comprising same, precursors and methods for preparing same, and methods of using same for diagnostic imaging of cancer cells and non-imaging tracer studies.Type: ApplicationFiled: May 15, 2009Publication date: November 18, 2010Inventors: Chris CHEESEMAN, Frederick WEST, Tina GRANT, Brendan TRAYNER, John MERCER, Andrei MANOLESCU
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Publication number: 20100290989Abstract: Compositions comprising hyaluronic acid (HA) or agents that interfere with HA binding of HA receptors and methods of using the same are provided. For example, there is provided a composition comprising HA oligomers ranging in size from 10-mer to 80-mer and use of the same for promoting migration, growth or survival of wild-type or transformed/cancerous cells. There is also provided a composition comprising an agent that interferes with binding between an HA oligomer of a size of about 10-mer to about 80-mer and an HA receptor. Such compositions may be useful for therapeutic, diagnostic or imaging applications. Examples of therapeutic use are wound repair or cancer treatment.Type: ApplicationFiled: October 10, 2008Publication date: November 18, 2010Applicants: LONDON HEALTH SCIENCES CENTRE RESEARCH INC., REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Cornelia Tolg, Eva Turley, Jim McCarthy, Leonard G. Luyt
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Publication number: 20100290990Abstract: The present invention relates to a method for preparing a 2-fluoropurine marked with the radioisotope 18F comprising a fluorination step for a 2-nitropurine derivative. The present invention comprises a 2-fluoropurine derivative marked with the radioisotope 18F which can be obtained by or during a method according to the invention and its various uses.Type: ApplicationFiled: December 23, 2008Publication date: November 18, 2010Inventors: Louisa Barre, Patrice Marchand
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Publication number: 20100272645Abstract: A myocardial imaging method that is accomplished by administering one or more adenosine A2A adenosine receptor agonist to a human undergoing myocardial imaging.Type: ApplicationFiled: January 27, 2010Publication date: October 28, 2010Inventor: Luiz Belardinelli
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Publication number: 20100254902Abstract: The invention relates to stabilised radiopharmaceutical compositions which comprise: (i) an 18F-labelled compound; (ii) an effective stabilizing amount of gentisic acid or a salt thereof with a biocompatible cation; (iii) an aqueous biocompatible carrier medium; wherein the radioactive concentration of the 18F in the carrier medium is in the range 10 to 100,000 MBq/ml and the pH of the composition is in the range 4.0 to 9.5. The invention further comprises methods for preparing such radiopharmaceutical compositions and a new use of gentisic acid or a salt thereof.Type: ApplicationFiled: November 4, 2008Publication date: October 7, 2010Inventor: Jan Van Den Bos
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Publication number: 20100254901Abstract: Disclosed herein are aptamers that comprise a nucleic acid sequence that has a specific affinity for a target. These aptamers can be used as delivery vehicles to deliver specific agents to particular sites. Alternatively, targeted aptamers can also be used with detection techniques to determine the presence of absence of specific targets in heterogeneous backgrounds.Type: ApplicationFiled: July 28, 2006Publication date: October 7, 2010Inventor: Cassandra L. Smith
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Publication number: 20100233081Abstract: A method is provided for treatment of disorders involving hyperproliferative cells, such as malignancies, advanced stage solid tumors like glioblastoma multiforme, and non-malignant hyperproliferative pathological conditions such as adult macular degeneration. A short range, unselective cell killing radiotherapeutic substance is administered, optionally in a spatially defined volume of tissue, optionally in combination with a mitogenic agent that stimulates or induces DNA biosynthesis. In this way, the percentage of hyperproliferative that are susceptible to killing by the radiotherapeutic agent is increased. Cancer stem cells can be induced to enter S phase with the mitogenic agent, then killed with the radiotherapeutic agent.Type: ApplicationFiled: May 9, 2008Publication date: September 16, 2010Applicant: PEAK BIOSCIENCE, INC.Inventors: Stephen L. Warren, James E. Matsuura, Michael J. Gerber
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Patent number: 7790140Abstract: In part, the present invention is directed to biocompatible compositions comprising a carrier with a first metal binding domain, a metal ion, an active agent with second metal binding domain and optionally a protective chain covalently attached to the polymeric carrier.Type: GrantFiled: July 5, 2006Date of Patent: September 7, 2010Assignee: PharmaIN CorporationInventor: Elijah M. Bolotin
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Publication number: 20100196272Abstract: The subject invention relates to the compositions for radiolabeling Diethylenetriaminepentaacetic Acid (DTPA)-dextran with Technetium-99m and for stabilizing the DTPA-dextran Cold Kit. The composition contains Stannous Chloride ions to reduce 99mTc-pertechnetate, Ascorbic Acid to reduce stannic ions to stannous ions to maintain a reducing environment, ?,?-Trehalose to add bulk and to stabilize the lyophilized composition without interfering with the radiochemical yield, and Glycine to transchelate Technetium-99m under highly acidic conditions to facilitate radiolabeling DTPA-dextran with high radiochemical purity. In addition, the invention pertains to methods for making and using the compositions. The reconstitution of the lyophilized composition by 99mTc-pertechnetate, resulting in radiolabeled 99mTc-DTPA-dextran in a composition between pH 3 to 4.Type: ApplicationFiled: January 30, 2009Publication date: August 5, 2010Applicant: NEOPROBE CORPORATIONInventors: Gerald Ross Magneson, Richard Cushman Orahood
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Publication number: 20100196273Abstract: Compounds for in vivo diagnostic imaging of cellular proliferation are provided. The compounds include L-nucleosides such as a 2?-deoxy-2?-fluoro-L-ara-binofuranosyl pyrimidine nucleoside analogue. These nucleosides are labeled with a positron emitting radioisotope. The present invention also provides a method for in vivo diagnostic imaging of cellular proliferation.Type: ApplicationFiled: February 11, 2008Publication date: August 5, 2010Inventors: Mian M. Alauddin, Uday Mukhopadhyay, Juri Gelovani, Ashutosh Pal, William Bornmann
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Publication number: 20100183512Abstract: Use of protein CTHRC1 or its nucleic acid in preparation for reagents or kits for diagnosing cancer of liver, the method for diagnosing cancer of liver by using the nucleic acid of CTHRC1, kit comprising the antibody to CTHRC1 or nucleic acid probe specific for the CTHRC1 protein and label, and the method for detecting the specific expression of protein CTHRC1 are disclosed.Type: ApplicationFiled: November 9, 2009Publication date: July 22, 2010Inventors: Wenxin QIN, Genfu Yao, Xiaozhen Wan, Shengli Yang, Jianren Gu
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Publication number: 20100178242Abstract: The invention provides a method for radiofluorination of biological vectors such as peptides comprising reaction of a compound of formula (II): or a salt thereof with a source of [18F]-fluoride, to give a compound of formula (I): or a salt thereof.Type: ApplicationFiled: June 18, 2008Publication date: July 15, 2010Inventors: Alexander Jackson, Rajiv Bhalla
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Patent number: 7744853Abstract: Radiolabeled annexin and modified annexin conjugates useful for imaging vascular thrombi are described. Methods for making and using such radiolabeled annexin conjugates are also provided.Type: GrantFiled: September 27, 2005Date of Patent: June 29, 2010Assignee: Poniard Pharmaceuticals, Inc.Inventors: Sudhakar Kasina, John M. Reno, Alan R. Fritzberg, Jonathan Tait
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Publication number: 20100150835Abstract: The present invention discloses the reactivity of ponytail (“PT”) sulfonates as leaving groups in nucleophilic fluorination reactions. The results showed that using a pentafluorobenzenesulfonate precursor is a suitable leaving group for n. c. a. nucleophilic 18F-fluorination in synthesis of [18F]fluoromethyl benzene, wherein this is a suitable leaving group for 18F-labeling with moderate reactivity. The PT-precursor seems to be quite stable. In an attempt to purify the crude 18F-labeled product using fluorous solid phase extraction (F-SPE), the radio labeled impurities decreased significantly. This provides an opportunity for utilizing PT methodology in both simple and fast purification methods.Type: ApplicationFiled: February 26, 2008Publication date: June 17, 2010Inventors: Bengt Langstrom, Farhad Karimi, Elisabeth Blom
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Patent number: 7727958Abstract: A pharmaceutical formulation for a PKC modulatory peptide and a transport moiety comprising the aforementioned components and an anti-aggregant.Type: GrantFiled: September 4, 2007Date of Patent: June 1, 2010Assignee: Kai Pharmaceuticals, Inc.Inventor: Mike Tso-ping Li
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Publication number: 20100119445Abstract: The present invention relates to plexin D1 for use as a targetable protein in the treatment or diagnosis of disorders that involve expression of plexin D1. Diagnosis is suitably effected by detecting the presence of plexin D1 in the body or a bodily tissue or fluid, whereas treatment is effected by targeting plexin D1 for delivery of therapeutics to the site where treatment is needed. The invention further relates to the use of molecules that bind plexin D1, a nucleic acid encoding plexine D1 or a ligand of plexin D1 for the preparation of a therapeutical composition for the treatment or diagnosis of disorders that involve expression of plexin D1. The disorders comprise disorders in which plexin D1 is expressed on tumor cells, tumor blood vessels or activated macrophages.Type: ApplicationFiled: July 20, 2006Publication date: May 13, 2010Applicant: N.V. OrganonInventors: Wilhelmus Petrus Johannes Leenders, Ilse Roodink, Jozef Maria Hendrik Raats
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Patent number: 7713528Abstract: This invention relates to novel reagent conjugates and a novel multi-step process for delivering active compounds to target analytes of interest in a patient for diagnostic and therapeutic purposes. According to the process, two novel reagents are bound to each other by linkage of the sequence-specific components they contain. The first reagent, which is comprised of a target recognition component and a first sequence-specific component, is introduced into the patient and allowed to achieve maximal localization on the target cells. The second reagent, which is comprised of an active compound component and a second sequence-specific component is then introduced into the patient, thereby forming a complex with the first reagent via the recognition and binding of the sequence-specific components of the two reagents to form the reagent conjugate of the invention. The active compound component is thereby efficiently and specifically delivered to the target analyte.Type: GrantFiled: June 7, 1995Date of Patent: May 11, 2010Assignee: Enzo Therapeutics, Inc.Inventors: Elazar Rabbani, Jannis G. Stavrianopoulos, Sherry P. Goltz
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Patent number: 7713514Abstract: An organized mobile multicomponent conjugate (OMMC) and method of using to enhance binding of weakly binding compounds to a target. A lamellar structure containing at least two binding compounds is assembled under conditions in which the binding compounds self-regulate in or on the lamellar structure, forming a cooperative ensemble that is capable of binding with enhanced affinity to a complementary affinity site on a target. Each binding compound is bound to the lamellar surface, and may be connected by a linker. The OMMC may contain an effector molecule, such as a diagnostic or therapeutic agent, for administration to a patent who is then diagnosed or treated using the effector molecule.Type: GrantFiled: August 4, 2006Date of Patent: May 11, 2010Assignee: Mallinckrodt Inc.Inventors: Gary L. Cantrell, B. Daniel Burleigh