Abstract: Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for improved radiohalogenation of biotin, as well as related compounds, are described. Also, clearing agents, anti-ligand-targeting moiety conjugates, target cell retention enhancing moieties and additional methods are discussed.
Type:
Grant
Filed:
January 27, 1997
Date of Patent:
September 11, 2001
Assignee:
NeoRx Corporation
Inventors:
John M. Reno, Louis J. Theodore, Linda M. Gustavson
Abstract: The present invention provides a single radioactive transition metal nitride heterocomplex which permits labeling of a physiologically active substance such as a peptide, hormone or the like without impairing the activity of the substance. The radioactive transition metal nitride heterocomplex of the present invention is represented by the following formula (I):
(M≡N)XY (I)
wherein a radioactive transition metal M is radioactive technetium or radioactive rhenium, N is a nitrogen atom, X is a diphosphine compound or a diarsine compound, and Y is a bindentate ligand having a combination of electron-donating atoms.
Abstract: Carboranyl-containing nucleosides and oligonucleotides are provided for use in boron neutron capture therapy (BNCT) and for other therapeutic and diagnostic purposes.
Type:
Grant
Filed:
December 2, 1993
Date of Patent:
January 30, 2001
Inventors:
Raymond F. Schinazi, Geraldin{acute over (e)} Fulcrand-El Kattan, Zbigniew Jan Lesnikowski