Abstract: Disclosed are a multipurpose, high-functional, alkaline solution composition, preparation therefor and use thereof as a nonspecific immunostimulator. The composition comprises 1-25 parts by weight of borax (Na2B4O7.10H2O), 10−5-10−4 parts by weight of sodium thiosulfate (Na2S2O3.5H2O), 30-150 parts by weight of potassium carbonate, 30-200 parts by weight of refined sugar (C12H22O11), and 100-200 parts by weight of water, based on 100 parts by weight of sodium metasilicate (Na2SiO3.5H2O). In addition to bringing about an improvement in disease resistance, weight gain rate, crop yield, crop quality, harvest time, the composition shows nonspecific immunostimulating activities, including antibody production and immune enhancement, by activating immune cells, thereby maximizing vaccination effects on malignant viral diseases.

Abstract: The present invention discloses compositions derived from an isolated Bacillus species, spores, or an extracellular product of Bacillus coagulans comprising a supernatant or filtrate of a culture of said Bacillus coagulans strain, suitable for topical application to the skin or mucosal membranes of a mammal, which are utilized to inhibit the growth of bacterium, yeast, fungi, virus, and combinations thereof. The present invention also discloses methods of treatment and therapeutic systems for inhibiting the growth of bacterium, yeast, fungi, virus, and combinations thereof, by topical application of therapeutic compositions which are comprised, in part, of isolated Bacillus species, spores, or an extracellular product of Bacillus coagulans comprising a supernatant or filtrate of a culture of said Bacillus coagulans strain.

Abstract: This invention provides a novel endophytic fungus, Muscodor, that produces a mixture of volatile antibiotics with activity on specific plant pathogens, bacteria, nematodes and insects. Also provided is a method for treating or protecting plants, soil and seeds from microbial infections comprising applying an effective amount of a volatile antibiotic producing Muscodor sp. The invention also relates to fungicidal, bactericidal, insecticidal and nematicidal compositions comprising this novel Muscodor strain and the antibiotics and metabolites produced by this strain either alone, or in combination with other chemical and biological pesticides. Also provided is a method for identifying and isolating related gas producing fungi.

Abstract: An animal-derived lipid is disclosed that is useful as a carrying agent for anti-microbial formulations. Pharmaceutical and other preparations including Emu Oil are also described as profoundly useful components in anti-bacterial, anti-fungal, and anti-viral treatments. This lipid material is extracted from the Emu (Dromais Novae-Hollandiae), an indigenous bird of Australia and New Zealand. The present invention also discloses therapeutic compositions comprising Emu Oil in combination with an extracellular product of Bacillus coagulans or Pseudomonas lindbergii strain, comprising a supernatant or filtrate of said culture suitable for topical application to the skin or mucosal membranes of a mammal, which are utilized to inhibit the growth of bacterium, yeast, fungi, virus, and combinations thereof. Additionally, the aforementioned therapeutic composition may also include an anti-microbial, anti-mycotic, and/or anti-viral agent.

Abstract: The invention relates to an antibiotic substance of microbial origin, arbitrarily denominated GE23077 complex and the individual factors which constitute it, a mixture of said factors in any proportion, the pharmaceutically acceptable salts and compositions thereof, and their use as an antibacterial agent having a selective inhibitory activity against E. coli RNA polymerase.

Abstract: This invention provides compositions and methods related to the administration of red yeast rice, coenzyme Q10, and chromium, with or without inositol hexanicotinate, selenium, and mixed tocopherols to reduce or control blood cholesterol, triglycerides, low density lipoproteins, or increasing or controlling high density lipoproteins in a mammal, to reduce arterial plaque build-up, atherosclerosis, in a mammal which may be associated with cardiovascular, cerebrovascular, peripheral vascular, or intestinal vascular disorders.

Abstract: A method of preparing a ruminant feed material with decreased nitrogen solubility, comprising mixing a liquid feed product containing a salt with a protein feedstuff. The protein feedstuff contains crude protein in an amount from 30% to 70% by weight. The liquid feed product containing a salt and the protein feedstuff are mixed under conditions sufficient to decrease the nitrogen solubility of the protein source. Also provided is a ruminant feed material with decreased nitrogen solubility.

Abstract: The present invention provides a novel strain of Microbispora corallina, means for identifying it, methods for culturing it at several different levels, two new antibiotics derived from the cultures and the physico-chemical characteristics of those compounds and their biological activity against a variety of microorganisms.

Abstract: This invention provides compositions and methods related to the administration of red yeast rice, coenzyme Q10, and chromium, with or without inositol hexanicotinate, selenium, and mixed tocopherols to reduce or control blood cholesterol, triglycerides, low density lipoproteins, or increasing or controlling high density lipoproteins in a mammal, to reduce arterial plaque build-up, atherosclerosis, in a mammal which may be associated with cardiovascular, cerebrovascular, peripheral vascular, or intestinal vascular disorders.

Abstract: A method of controlling various insect pests on a plant is disclosed which consists of attracting, augmenting or conserving natural enemies of the insect pests in order to produce a population of the natural enemies sufficient to control the insect pest by applying to the plant an effective amount of a brewer's yeast, S. cerevisiae YESTA 20B (a dried debittered brewer's yeast).

Abstract: This invention provides compositions and methods related to the administration of red yeast rice, coenzyme Q10, and chromium, with or without inositol hexanicotinate, selenium, and mixed tocopherols to reduce or control blood cholesterol, triglycerides, low density lipoproteins, or increasing or controlling high density lipoproteins in a mammal, to reduce arterial plaque build-up, atherosclerosis, in a mammal which may be associated with cardiovascular, cerebrovascular, peripheral vascular, or intestinal vascular disorders.

Abstract: The present invention is directed to a method for producing a new nematocidal composition particularly useful against plant parasitic nematodes and also a process to prevent damage resulting from nematode infestation. The method for production of the composition involves heating a pH-adjusted fermentation broth of microorganisms to a temperature of at least about 100° C. for at least about 15 minutes. Preferably, the microorganism is Gibberella fujikuroi, Streptomyces erythraeus, Bacillus sphaericus, Bacillus thuringiensis or Fusarium moniliforme.

Abstract: This invention provides compositions and methods related to the administration of red yeast rice, coenzyme Q10, and chromium, with or without inositol hexanicotinate, selenium, and mixed tocopherols to reduce or control blood cholesterol, triglycerides, low density lipoproteins, or increasing or controlling high density lipoproteins in a mammal, to reduce arterial plaque build-up, atherosclerosis, in a mammal which may be associated with cardiovascular, cerebrovascular, peripheral vascular, or intestinal vascular disorders.

Abstract: The purpose of the present invention is to offer an intestinal activation food product containing natto powder that delivers the natto bacteria live.to the intestines and produces an adequate intestinal regulating effect by enhancing the mitotic growth of the natto bacteria delivered to the intestines and, furthermore, a product that is easy to take without causing the offensive smell peculiar to natto during storage. For this reasons, the intestinal activation food product containing natto powder in accordance with this invention is a uniform blend obtained by blending to 15 wt. % of natto powder containing the natto bacteria with 50 wt. % of lactose as the growth factor substance, 30 wt. % of 300 mesh particle size coffee powder as the porous substance and 5 wt. % of sporophyte-containing lactic acid bacilli as the germination inducing substance and filling 0.5 g of this mixture into a hard capsule.

Abstract: An animal-derived lipid is disclosed that is useful as a carrying agent for anti-microbial formulations. Pharmaceutical and other preparations including Emu Oil are also described as profoundly useful components in anti-bacterial, anti-fungal, and anti-viral treatments. This lipid material is extracted from the Emu (Dromais Novae-Hollandiae), an indigenous bird of Australia and New Zealand. The present invention also discloses therapeutic compositions comprising Emu Oil in combination with an extracellular product of Bacillus coagulans or Pseudomonas lindbergii strain, comprising a supernatant or filtrate of said culture suitable for topical application to the skin or mucosal membranes of a mammal, which are utilized to inhibit the growth of bacterium, yeast, fungi, virus, and combinations thereof. Additionally, the aforementioned therapeutic composition may also include an anti-microbial, anti-mycotic, and/or anti-viral agent.

Abstract: A pesticide composition that includes a metabolite from a fungus selected from homeocarpic basidiomycetes and homeocarpic ascomycetes is produced. In one embodiment, the fungus from which the metabolite is derived is one grown under conditions effective to substantially suppress fruiting of the fungus. More particular the pesticide compositions are provided comprising a fungal metabolite derived from a fungus selected from the group Ganoderma spp., Lactiporus spp. Lentinus spp. Morchella spp., and Pleurotus spp. The pesticide composition may be produced by culturing the fungus on a medium containing vegetable oil and a surfactant. Alternatively a filtrate from a culture of the fungus is added to the medium containing vegetable oil and a surfactant, and mixed until pesticidal activity develops.

Abstract: This invention provides compositions and methods related to the administration of red yeast rice, coenzyme Q10, and chromium, with or without inositol hexanicotinate, selenium, and mixed tocopherols to reduce or control blood cholesterol, triglycerides, low density lipoproteins, or increasing or controlling high density lipoproteins in a mammal, to reduce arterial plaque build-up, atherosclerosis, in a mammal which may be associated with cardiovascular, cerebrovascular, peripheral vascular, or intestinal vascular disorders.

Abstract: A therapeutic agent for a cancer comprising a therapeutically effective amount of an active ingredient, wherein the therapeutic agent is used referring to an ability of acting on NK cell antigen receptor NKR-P1 of NKT cell as an index of the ability to activate the NKT cell.

Abstract: Disclosed are a multipurpose, high-functional, alkaline solution composition, preparation therefor and use thereof as a nonspecific immunostimulator. The composition comprises 1-25 parts by weight of borax (Na2B4O7.10H2O), 10−5-10−4 parts by weight of sodium thiosulfate (Na2S2O3.5H2O), 30-150 parts by weight of potassium carbonate, 30-200 parts by weight of refined sugar (C12H22O11), and 100-200 parts by weight of water, based on 100 parts by weight of sodium metasilicate (Na2SiO3.5H2O). In addition to bringing about an improvement in disease resistance, weight gain rate, crop yield, crop quality, harvest time, the composition shows nonspecific immunostimulating activities, including antibody production and immune enhancement, by activating immune cells, thereby maximizing vaccination effects on malignant viral diseases.

Abstract: A novel tyrosyl diester antibiotic is obtained from fermentation of a recombinant strain of Streptomyces lividans designated Stretomyces lividans WD 15684 (ATCC-202143). The new antibiotic, designated tyrissamycin, exhibits antibacterial activity, particularly against gram-positive bacteria.

Abstract: The present invention relates to a porous structure of prepared fungal cell wall components, whereby the cell wall material is derived from a fungi selected from the division Zygomycota, the fungal material in the form of a suspension is subjected to drying in such a way that the material obtains a porous structure, the structure has a liquid absorbing property which is at least 15 ml/g of 1% NaCl (aq) and it has a liquid transporting ability of water, at a density of 0.01 to 0.03 g/cm3, in a horizontal direction of at least 10 mm during the first minute of absorption and in a vertical direction of at least 5 mm during a first minute of absorption.

Abstract: The present invention pertains to novel strains of the Bacillus subtilis group capable of fermenting beans, which are essentially devoid of any iso-valeric acid production. The present invention especially relates to novel strains of Bacillus natto, in which one or more genes involved in the biosynthetic pathway for the production of iso-valeric acids are essentially non-functional.

Abstract: This invention includes methods and compositions for generating signaling complexes (“Signal-plexes”) and the use of Signal-plexes for inducing cell divisions, differentiation and transdifferentiation of cells into specific cell, tissue or organ types which resemble the cells, tissues or organs from which the Signal-plexes were derived.

Abstract: A pesticide composition that includes a metabolite from a fungus selected from homeocarpic basidiomycetes and homeocarpic ascomycetes is described. In one embodiment, the fungus from which the metabolite is derived is one grown under conditions effective to substantially suppress fruiting of the fungus. More particular the pesticide compositions are provided comprising a fungal metabolite derived from a fungus selected from the group Ganoderma spp., Lactiporus spp., Lentinus spp., Morchella spp., and Pleurotus spp. The pesticide composition may be produced by culturing the fungus on a medium containing vegetable oil and a surfactant. Alternatively a filtrate from a culture of the fungus is added to the medium containing vegetable oil and a surfactant, and mixed until pesticidal activity develops.

Abstract: The antioxidation food product of the present invention is a fermented product produced by adding a manganese-containing natural material such as tea and fermenting with bacteria having a catalase activity (e.g. Lactobacillus plantarum). The antioxidation food product has an antioxidation action in the living body including the interior of a digestive tract by expressing a superoxide dismutase-like activity and a catalase activity, simultaneously, and is effective for preventing diseases caused by active oxygen.

Abstract: The present invention relates a process for culturing isolates of Antrodia camphorata to provide a product useful in medical and nourishment fields. The present invention also relates to a novel isolate of Antrodia camphorata capable of growing in a suitable artificial medium, while exhibiting desired pharmacological activities, in particular anti-tumor activity. The utilization of potato dextrose broth and the synthetic medium containing fructose as major carbon source leads to a significant increase in the pharmacological activity of the cultures of A. camphorate.

Abstract: Process for producing a hydrochloride of a vancomycin antibiotic, comprising subjecting an aqueous solution of a hydrochloride of a vancomycin antibiotic to a primary freezing at from −1° C. to −20° C. for a time sufficient to grow ice crystals, to form a primarily frozen substance, then subjecting said primarily frozen substance to a secondary freezing at from −25° C. to −80° C. to form a completely frozen solid, and then drying the resulting frozen solid in vacuo; and product obtained by the process.

Abstract: Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. The medium may be conditioned by stromal cells, parenchymal cells, mesenchymal stem cells, liver reserve cells, neural stem cells, pancreatic stem cells and/or embryonic stem cells. Additionally, the cells may be genetically modified. A three-dimensional tissue construct is preferred. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder.

Abstract: The invention provides a method of inhibiting TNF comprising administering a TNF-inhibiting amount of an extract of Eleutherococcus senticosus maxim to a subject. Also, the present invention provides a method inhibiting TNF in a cell comprising administering to the cell a TNF inhibiting amount of an extract from Eleutherococcus senticosus maxim. Finally, the invention provides a method of treating a TNF mediated disorder in a subject, comprising administering a therapeutic amount of an extract of Eleutherococcus senticosus maxim to the subject.

Abstract: The invention relates to low-molecular weight, metabolism-activating mixtures of active ingredients from yeast fungi of the order Saccharomycetes and is characterized in that they are obtained from yeasts of the said order of Saccharomycetes, which are cultivated for some hours at temperatures starting at 37° C., are heated to a maximum of 45° C. and, following cooling, are subsequently processed in a manner known per se.

Abstract: There is provided a substance which was isolated from the germinated seed of a grass family plant and which contains proteins and insoluble dietary fibers. There are also provided a pharmaceutical composition comprising as an active ingredient said substance which was isolated from the germinated seed of a grass family plant and which contains proteins and insoluble dietary fibers, and a food composition comprising said substance which was isolated from the germinated seed of a grass family plant and which contains proteins and insoluble dietary fibers, as well as uses of said substance.

Abstract: Antimicrobial agents and method for isolation thereof from the gel liquid of Aloe vera includes at least one antimicrobial agent isolated from the clear gel isolated from the whole leaf of the Aloe vera plant, wherein the antimicrobial agent is an agent produced by the Aloe vera and/or indigenous bacteria that colonize the Aloe vera plant, is disclosed.

Abstract: Disclosed is a mixture excellent in coagulation of fats and oils together with a method of powdering the Aureobacidium culture solution. Formation of a powdered clathrate that is formed by including the Aureobacidium culture solution as a guest component into cyclodextrin as a host component improves its physical properties and shelf life. Preferably, chitosan is added to the above-described composition of the powdered Aureobacidium culture solution.

Abstract: A novel tyrosyl diester antibiotic is obtained from fermentation of a recombinant strain of Streptomyces lividans designated Streptomyces lividans WD 15684 (ATCC-202143). The new antibiotic, designated tyrissamycin, exhibits antibacterial activity, particularly against gram-positive bacteria.

Abstract: The present invention discloses a process for producing erythritol by fermentation using a polysaccharide negative erythritol producing strain and recovering erythritol crystals by direct crystallization from the unrefined micro-organism-free fermentation broth. Direct crystallization of erythritol is performed at dry substance higher than 80% w/w. Recovery of erythritol crystals is at least 85% and purity of erythritol crystals is at least 99% w/w.

Abstract: The present invention provides an agent for inducing resistance against phytophathogenic microorganisms in plants wherein the agent is an extract of biomass from non-plant-pathogenic microorganisms obtainable by the following process: a) resuspending 50 g to 200 g (dry weight) of biomass from non-plant-pathogenic microorganisms per liter of inorganic or organic solvent; b) stirring at room temperature for 1 to 12 hours; c) incubating; d) resuspending; e) allowing to cool to room temperature; and f) optionally filtering.

Abstract: The present invention provides methods to isolate and purify components required for bone-induction using extracts of Saos-2 cells or proteins released by Saos-2 cells into conditioned tissue culture medium. In addition, the present invention provides a method of augmenting bone growth locally comprising implanting the near osteoprogenitor cells the bone inducing agent isolated in the methods of the present invention, together with a mechanically suitable biodegradable carrier.

Abstract: The present invention is directed to a method for producing a new nematocidal composition particularly useful against plant parasitic nematodes and also a process to prevent damage resulting from nematode infestation. The method for production of the composition involves heating a pH-adjusted fermentation broth of microorganisms to a temperature of at least about 100° C. for at least about 15 minutes. Preferably, the microorganism is Gibberella fujikuroi, Streptomyces erythraeus, Bacillus sphaericus, Bacillus thuringiensis or Fusarium moniliforme.

Abstract: The present invention has for its object to provide a method for obtaining a barley malt oil abundantly containing ceramide derivatives of plant origin which is highly safe and gives a good image as a material in an efficient, simple and easy manner as well as to provide a barley malt oil which is obtained by such method above and is enriched in highly safe ceramide derivatives. The present invention provides a method for producing barley malt oil containing ceramide derivatives, comprising the steps of: dipping spent grains obtained in a process of beer production in a polar organic solvent as a dipping solution, separating an extract liquid from the dipping solution, and concentrating the extract liquid and also provides a barley malt oil containing ceramide derivatives obtainable by dipping spent grains obtained in a process of beer production in a polar organic solvent, separating an extract liquid from the resulting solution, and concentrating the extract liquid.

Abstract: An animal-derived lipid is disclosed that is useful as a carrying agent for anti-microbial formulations. Pharmaceutical and other preparations including Emu Oil are also described as profoundly useful components in anti-bacterial, anti-fungal, and anti-viral treatments. This lipid material is extracted from the Emu (Dromais novae-hollandiae), an indigenous bird of Australia and New Zealand. The present invention also discloses therapeutic compositions comprising Emu Oil in combination with an extracellular product of Bacillus coagulans or Pseudomonas lindbergii strain, comprising a supernatant or filtrate of said culture suitable for topical application to the skin or mucosal membranes of a mammal, which are utilized to inhibit the growth of bacterium, yeast, fungi, virus, and combinations thereof. Additionally, the aforementioned therapeutic composition may also include an anti-microbial, anti-mycotic, and/or anti-viral agent.

Abstract: Disclosed is a process for producing antioxidants, which comprises the following steps:

Abstract: A product which contains a health-promoting component and a process for preparing such a product, in the present invention, using a pulse crop as a raw material. The product accomplishes health promotion very effectively by means of at least one member of the group consisting of liver function improving constituents, cardiac function improving constituents, anti-inflammatory constituents, antifat constituents, antioxidation consititents, antimutagen constituents, and components which have an intestine-regulating effect in single-stomached animals; and the method produces such a product with good efficiency. The product of the present invention can be used directly “as is”; and alternatively, specified components may be concentrated or may be usefully utilized in applied products which use the product of the present invention as a raw material, e. g., food products, livestock feeds, pet foods or drug raw materials, etc.

Abstract: There is provided a substance which was isolated from the germinated seed of a grass family plant and which contains proteins and insoluble dietary fibers. There are also provided a pharmaceutical composition comprising as an active ingredient said substance which was isolated from the germinated seed of a grass family plant and which contains proteins and insoluble dietary fibers, and a food composition comprising said substance which was isolated from the germinated seed of a grass family plant and which contains proteins and insoluble dietary fibers, as well as uses of said substance.

Abstract: A method for producing a novel yeast and mold inhibiting products (FIC) from a Lactobacillus, particularly a Lactobacillus casei having the yeast and mold producing characteristics of Lactobacillus casei var. rhamnosus NRRL-B-15972 is described. The products (FIC) are particularly useful in retarding yeast and mold growth in foods and other materials in need thereof.

Abstract: The present invention provides an agent for inducing resistance against phytopathogenic microorganisms in plants wherein the agent is an extract of biomass from non-plant-pathogenic microorganisms obtainable by the following process: a) resuspending 50 g to 200 g (dry weight) of biomass from non-plant-pathogenic microorganisms per liter of inorganic or organic solvent; b) stirring at room temperature for 1 to 12 hours; c) incubating; d) resuspending; e) allowing to cool to room temperature; and f) optionally filtering.

Abstract: A method of controlling moth and other insect pests in a habitat and attracting, augmenting or conserving natural enemies of the moth or other insect pests, which comprises treating the habitat with yeast.

Abstract: The invention concerns a cosmetic or pharmaceutical composition. This composition is characterised in that it contains a microbial culture compatible in cosmetics or in pharmacy or in therapy, in particular a culture of micro-organisms selected among the acetic or lactic bacteria, freeze-dried yeast, suspensions of micro-organisms, fermented organic substances, for example fermented pollen, or an inactivated culture of bacteria of the genus bifidobacterium or of bacteria related to this genus mixed with an essential oil and an acid preferably an organic acid, such as citric acid. This composition has an activity for regenerating the skin, in particular anti-wrinkle properties, for erasing old scars, for repairing burnt tissues, for promoting skin healing, for eliminating pigmentary spots and also for promoting growth or fresh growth of superficial body growth including nails, hair or hairs.

Abstract: The invention discloses a two-step process for recovery of thuringiensin, comprising adsorbing the thuringiensin from fermentation broth by calcium silicate, and dissociating the thuringiensin by dibasic sodium phosphate. The resulting thuringiensin can be further purified by using semi-preparative HPLC and electrodialysis to remove the excess salts from the recovered thuringiensin solution.

Abstract: This invention relates to a method for preparation of biologically active substances and has the following characteristic features: (a) nacre is reduced to a powder whose grain size is less than approximately 200 &mgr;m; (b) it is placed in close contact with an aqueous solvent, (c) at the end of the contact period, the insoluble fraction is separated out to give the aqueous fraction; (d) the solvent of the aqueous fraction is concentrated to separate out the soluble or water-transportable fraction of the nacre, which is made up of biologically active substances with essentially no mineral components. The invention likewise relates to the products obtained by this method, their use for medicinal purposes and the compositions containing them.

Abstract: A method is presented for treating hyperkeratotic diseases such as psoriasis which comprises applying a lysate of Halobacterium halobium to the effected skin area and irradiating with light. The preferred treatment involves multiple applications of a 2% composition of the lysate and irradiation for a period of twenty to sixty minutes with a 300 watt lamp.