Over 62% Carbon Patents (Class 424/122)
  • Rapamycin and process of preparation
    Patent number: 3993749
    Abstract: Antibiotic rapamycin is producible by culturing Streptomyces hygroscopicus NRRL 5491 in an aqueous nutrient medium. Rapamycin has antifungal properties. Methods for its preparation and use are disclosed.
    Type: Grant
    Filed: September 25, 1975
    Date of Patent: November 23, 1976
    Assignee: Ayerst McKenna and Harrison Ltd.
    Inventors: Surendra N. Sehgal, Teodora M. Blazekovic, Claude Vezina
  • Antibiotic substances B-41, their production and their use as insecticides and acaricides
    Patent number: 3992527
    Abstract: New antibiotic substances are obtained by culturing a strain belonging to the genus Streptomyces and recovering said substances from the culture material. The new antibiotic substances possess insecticidal and acaracidal properties.
    Type: Grant
    Filed: August 13, 1975
    Date of Patent: November 16, 1976
    Assignee: Sankyo Company Limited
    Inventors: Atsushi Aoki, Rikiya Fukuda, Toshio Nakayabu, Keijiro Ishibashi, Chiyoko Takeichi, Mitsuo Ishida
  • Dihydro-A204
    Patent number: 3985872
    Abstract: Dihydro-A204, prepared by reduction of antibiotic A204I, and the physiologically-acceptable cationic salts thereof increase feed-utilization efficiency in ruminants and are anticoccidial agents.
    Type: Grant
    Filed: November 15, 1974
    Date of Patent: October 12, 1976
    Assignee: Eli Lilly and Company
    Inventor: James W. Chamberlin
  • Compound NA-337 and a process for producing the same by fermentation
    Patent number: 3974273
    Abstract: This invention relates to a new compound NA-337 and a process for producing the same by fermentation. NA-337 is positive in Dragendorff's reagent. NA-337 is confirmed to be a new compound having a fat-clearing activity. This compound is produced by fermentation, in which an NA-337-producing strain is cultured aerobically in a medium and the accumulated NA-337 is recovered from the cultured matters.
    Type: Grant
    Filed: March 14, 1975
    Date of Patent: August 10, 1976
    Assignee: The Kitasato Institute
    Inventors: Satoshi Omura, Haruo Tanaka, Juichi Awaya, Yaeko Konda, Yoshitsugu Narimatsu, Masayuki Onda
  • Antibiotic substances B-41, their production and their use as insecticides and acaricides
    Patent number: 3966914
    Abstract: This invention relates to new antibiotic substances B-41, a process for producing the antibiotic substance B-41 by culturing in a medium a B-41 producing strain belonging to the genus Streptomyces and then recovering the resulting B-41 from the cultured substance, and an insecticidal and acaricidal composition containing novel antibiotic substances B-41 as an active ingredient.
    Type: Grant
    Filed: October 31, 1974
    Date of Patent: June 29, 1976
    Assignee: Sankyo Company Limited
    Inventors: Atsushi Aoki, Rikiya Fukuda, Toshio Nakayabu, Keijiro Ishibashi, Chiyoko Takeichi, Mitsuo Ishida
  • Esters of partricin derivatives
    Patent number: 3961047
    Abstract: The present invention provides new esters of partricin and of N-substituted derivatives of partricin.
    Type: Grant
    Filed: February 13, 1974
    Date of Patent: June 1, 1976
    Assignee: SPA-Societa Prodotti Antibiotici S.p.A.
    Inventors: Tiberio Bruzzese, Giuseppe Ghielmetti
  • Water-solubilized antibiotics
    Patent number: 3961048
    Abstract: The present invention provides a water-soluble pharmaceutical composition, comprising partricin and/or partricin methyl ester in admixture with at least one anionic and/or cationic surfactant.
    Type: Grant
    Filed: May 14, 1974
    Date of Patent: June 1, 1976
    Assignee: SPA-Societa prodotti Antibiotici S.p.A.
    Inventors: Ernani Dell'Acqua, Rodolfo Ferrari
  • Antibiotic equisetin and method of production
    Patent number: 3959468
    Abstract: An antibiotic produced by Fusarium equiseti NRRL 5537 and given the trivial name equisetin is active against several genera of gram-positive bacteria.
    Type: Grant
    Filed: May 6, 1974
    Date of Patent: May 25, 1976
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventor: Harland R. Burmeister
  • Antibiotic derivatives
    Patent number: 3949079
    Abstract: A process for producing the antibiotic pleuromutilin by cultivating strains of Clitopilus passeckerianus (Pil.) Sing in an aqueous nutrient medium. The production of esters of pleuromutilin and hydrogenation products thereof are also described. The pleuromutilin and derivatives thereof are useful as an antibacterial ingredient in animal feed compositions.
    Type: Grant
    Filed: August 14, 1967
    Date of Patent: April 6, 1976
    Assignee: Biochemie Ges.m.b.H.
    Inventors: Ernst Brandl, Franz Knauseder, Franz Rembold
  • Triols and acetates thereof derived from antibiotic substance, acid S, produced by polyangium cellulosum var. fulvum
    Patent number: 3932621
    Abstract: The present invention relates to triols derived from antibiotic substance, designated acid S, produced by Polyangium cellulosum var. fulvum (ATCC No. 25532), to the acetates thereof and to processes for the production of the triols and corresponding acetates. These triols and acetates are potent antifungal agents inhibiting the growth of a variety of fungi, including H. capsulatum, T. mentagrophytes and M. fulvum.
    Type: Grant
    Filed: June 24, 1974
    Date of Patent: January 13, 1976
    Assignees: Max VON Strandtmann, Warner-Lambert Company
    Inventors: David T. Connor, Samuel M. Ringel
  • Ketones and ketoximes derived from acid S, an antibiotic produced by polyangium cellulosum var. fulvum
    Patent number: 3932620
    Abstract: The present invention relates to keto and ketoxime derivatives of the novel antibiotic substance, acid S, produced by the microorganism Polyangium cellulosum var. fulvum (ATCC N0. 25532) and to processes for their preparation. The novel keto and ketoxime derivatives of acid S of this invention are useful antifungal agents.
    Type: Grant
    Filed: June 24, 1974
    Date of Patent: January 13, 1976
    Assignee: Warner-Lambert Company
    Inventors: David T. Connor, Samuel M. Ringel, Maximilian VON Strandtmann
  • Antibiotic X-5108 for stimulating growth
    Patent number: RE28700
    Abstract: A new antibiotic, designated as antibiotic X-5108, is produced by a new species of streptomyces. The new antibiotic is active against gram-positive and gram-negative bacteria and produces growth stimulation and increased feed efficiency in poultry.
    Type: Grant
    Filed: December 11, 1972
    Date of Patent: January 27, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Julius Berger