Pasteurella (e.g., Pasteurella Multocida, Pasteurella Hemolytica, Etc.) Patents (Class 424/255.1)
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Patent number: 7449178Abstract: Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is equal or more than 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% with an amino acid sequence coded by a nucleotide sequence selected from the group consisting of nucleotide sequences identified SEQ ID NO: 2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93; said mutation resulting in attenuated virulence of the bacterium. Immunogenic compositions and vaccines containing such a mutant are also disclosed and claimed.Type: GrantFiled: April 3, 2003Date of Patent: November 11, 2008Assignee: Merial LimitedInventors: Helen Rachel Crooke, Jacqueline Elizabeth Shea, Robert Graham Feldman, Sylvain Gabriel Goutebroze, Francois-Xavier Le Gros
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Publication number: 20080241192Abstract: The present invention provides methods for inducing cross-protective immunity against virulent strains of P. multocida in animals such as cattle and poultry. The methods of the invention include administering to an animal a mutant P. multocida strain, whereby the mutant P. multocida strain induces cross-protective immunity against one or more virulent P. multocida strains having serotypes that are different from the serotype of the mutant P. multocida strain. The mutant P. multocida strain will preferably contain one or more mutations that cause the cells to be acapsular and/or attenuated. Exemplary mutations include, e.g., mutations that impair the expression of one or more genes in the P. multocida capsule biosynthetic operon (e.g., phyB, phyA, hyaE, hyaD, hyaC, hyaB, hexD, hexC, hexB, and/or hexA).Type: ApplicationFiled: March 25, 2008Publication date: October 2, 2008Applicant: WyethInventors: Mahesh Kumar, Christine Anschutz, Jean Q. Tian
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Patent number: 7413743Abstract: The invention provides a vaccine for immunizing poultry and other animals against infection by a gram-negative bacteria, and a method of immunizing an animal using the vaccine. The vaccine may contain purified siderophore receptor proteins derived from a single strain or species of gram-negative bacteria or other organism, which are cross-reactive with siderophores produced by two or more strains, species or genera of gram-negative bacteria. The invention further provides a process for isolating and purifying the siderophore receptor proteins, and for preparing a vaccine containing the proteins. Also provided is a method for diagnosing gram-negative sepsis.Type: GrantFiled: June 8, 2005Date of Patent: August 19, 2008Assignee: Epitopix, LLCInventors: Daryll A. Emery, Darren E. Straub
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Patent number: 7371393Abstract: The present invention provides methods for reducing shedding in an animal. Generally, the method includes administcriirn to an animal a composition including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide at a concentration of no greater than about 10.0 endotoxin units per milliliter.Type: GrantFiled: March 22, 2006Date of Patent: May 13, 2008Assignee: Epitopix, LLCInventors: Daryll A. Emery, Darren E. Straub
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Patent number: 7351416Abstract: Acapsular hyaE deletion mutants of P. multocida can be administered to mammals, particularly ungulates, or birds to provide protective immunity against wild-type P. multocida, e.g., to prevent or reduce the severity of hemorrhagic septicemia or pneumonia in mammals, particularly livestock, ungulates, and companion animals, or fowl cholera in birds, particularly poultry.Type: GrantFiled: July 2, 2004Date of Patent: April 1, 2008Assignee: The United States of America as represented by the Department of AgricultureInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 7341732Abstract: The present invention provides methods for treating mastitis in a milk producing animal. The methods include administering compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide at a concentration of no greater than about 10.0 endotoxin units per milliliter.Type: GrantFiled: April 22, 2004Date of Patent: March 11, 2008Assignee: Epitopix, LLCInventors: Daryll A. Emery, Darren E. Straub
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Patent number: 7160549Abstract: The present invention provides methods for making compositions including siderophore receptor polypeptides and porins from gram negative microbes. The methods include providing a gram negative microbe, disrupting the microbe, solubilizing the disrupted microbe, and isolating the polypeptides.Type: GrantFiled: April 22, 2004Date of Patent: January 9, 2007Assignee: Epitopix, LLCInventors: Daryll A. Emery, Darren E. Straub, Donavan E. Zammert, Gayla K. Kallevig
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Patent number: 7144580Abstract: Vaccines and methods against M. haemolytica infections in cattle. The vaccine compositions include a recombinant outer membrane protein of M. haemolytica designated PlpE and/or subunits thereof, alone or in combination with other antigenic components, and a carrier or diluent. The methods involve administering an effective immunizing amount of the vaccines to susceptible bovine.Type: GrantFiled: September 27, 2005Date of Patent: December 5, 2006Assignee: The Board of Regents for Oklahoma State UniversityInventors: Anthony W. Confer, Sahlu Ayalew, George L. Murphy, Karamjeet Pandher
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Patent number: 7138124Abstract: The present invention provides compositions including at least two siderophore receptor polypeptides and at least two porins from a gram negative microbe, and preferably, lipopolysaccharide at a concentration of no greater than about 10.0 endotoxin units per milliliter. The present invention also provides methods of makino and methods of using such compositions.Type: GrantFiled: June 3, 2003Date of Patent: November 21, 2006Assignee: Epitopix, LLCInventors: Daryll A. Emery, Darren E. Straub, Donavan E. Zammert, Gayla K. Kallevig
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Patent number: 6936262Abstract: Mutants of P. haemolytica provide excellent safety and efficacy when used as vaccines in ruminants, for example cattle, sheep, and goats, subject to pneumonic pasteurellosis. They can be administered by a variety of routes. Especially preferred is the use in animal feeds. The mutants are not reverting and contain no foreign DNA and no introduced antibiotic resistance genes.Type: GrantFiled: January 25, 2002Date of Patent: August 30, 2005Assignee: Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 6814971Abstract: The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local reactions to the vaccine in the injected animal.Type: GrantFiled: March 13, 2003Date of Patent: November 9, 2004Assignee: Pfizer Inc.Inventors: David S. Roberts, Leroy A. Swearingin, Don A. Dearwester
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Patent number: 6797272Abstract: New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which comprise a leukotoxin polypeptide fused to a selected antigen. The leukotoxin functions to increase the immunogenicity of the antigen fused thereto.Type: GrantFiled: November 24, 1997Date of Patent: September 28, 2004Assignee: University of SaskatchewanInventors: Andrew A. Potter, Mark J. Redmond, Huw P. A. Hughes
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Patent number: 6793927Abstract: Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica. A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the methyltransferase has allowed construction of defined, attenuated mutants for use as vaccines to protect cattle.Type: GrantFiled: December 15, 1998Date of Patent: September 21, 2004Assignees: The United States of America as represented by the Secretary of the Department of Agriculture, Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 6743430Abstract: Disclosed herein is a multicomponent low dose vaccine comprising a safe and immunogenically effective combination of a protective antigen component or components of clostridial organism, a protective antigen component of a non-clostridial organism and an adjuvant.Type: GrantFiled: March 29, 1995Date of Patent: June 1, 2004Inventors: Richard E. Parizek, Lonny E. Vlieger, Sharon A. Bryant, Stuart K. Nibbelink, Michael J. McGinley
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Patent number: 6733754Abstract: The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local reactions to the vaccine in the injected animal.Type: GrantFiled: March 13, 2003Date of Patent: May 11, 2004Assignees: Pfizer, Inc., Pfizer Products, Inc.Inventors: David S. Roberts, Leroy A. Swearingin, Don A. Dearwester
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Publication number: 20030175309Abstract: The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local reactions to the vaccine in the injected animal.Type: ApplicationFiled: March 13, 2003Publication date: September 18, 2003Inventors: David S. Roberts, Leroy A. Swearingin, Don A. Dearwester
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Patent number: 6610506Abstract: Novel transferrin binding proteins from Pasteurella haemolytica, and nucleic acid molecules encoding the novel proteins are disclosed. Antibodies against the novel proteins are disclosed. The invention also relates to vaccines containing the novel proteins of the invention. The invention also provides methods for identifying substances which affect the binding of transferrin to the proteins and methods for screening for agonists or antagonists of the binding of the proteins and transferrin.Type: GrantFiled: November 29, 1996Date of Patent: August 26, 2003Assignees: University Technologies International, Inc., University of Guelph, University of SaskatchewanInventors: Reggie Y. C. Lo, Anthony Bernard Schryvers, Andrew Allan Potter
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Patent number: 6610307Abstract: Bovine respiratory disease (BRD) complex, shipping fever, or pneumomic pasteurellosis, is a multifactorial disease whereby a combination of viral infection, adverse environment and poor immune status may combine to predispose animals to bacterial infections. The exotoxin, or leukotoxin (Lkt), may contribute to pathogenesis by impairing the primary lung defenses and subsequent immune responses or by causing inflammations as a result of leukocyte lysis. The present invention provides a modified microorganism which produces an Lkt toxin, wherein said Lkt toxin is partially or fully inactivated. In a further embodiment of the present invention, there is provided a modified microorganism wherein an Lkt toxin operon including an Lkt structural gene and/or a post transational activator of the organism is partially or fully inactivated. The present applicants have found that a precursor of Lkt toxin has reduced toxic activity.Type: GrantFiled: June 23, 1998Date of Patent: August 26, 2003Assignees: Commonwealth Scientific and Industrial Research Organisation, The State of Queensland Through its Department of Primary Industries, The State of New South Wales Through its Department of Agriculture, The University of New England of ArmidaleInventors: Christopher Thomas Prideaux, Adrian Leslie Mark Hodgson
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Patent number: 6585981Abstract: The present invention provides a live temperature-sensitive vaccine for Mycoplasma hyopneumoniae. The present invention also provides methods of vaccinating a swine against colonization or infection of Mycoplasma hyopneumoniae.Type: GrantFiled: July 27, 2000Date of Patent: July 1, 2003Assignee: Regents of the University of MinnesotaInventor: Carlos Pijoan
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Patent number: 6572861Abstract: The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local reactions to the vaccine in the injected animal.Type: GrantFiled: January 24, 2000Date of Patent: June 3, 2003Inventors: David S. Roberts, Leroy A. Swearingin, Don A. Dearwester
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Patent number: 6573093Abstract: Mutants of P. haemolytica provide excellent safety and efficacy when used as vaccines in ruminants, for example cattle, sheep, and goats, subject to pneumonic pasteurellosis. They can be administered by a variety of routes. Especially preferred is the use in animal feeds. The mutants are not reverting and contain no foreign DNA and no introduced antibiotic resistance genes.Type: GrantFiled: October 19, 2001Date of Patent: June 3, 2003Assignee: Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 6495145Abstract: Mutants of P. haemolytica provide excellent safety and efficacy when used as vaccines in ruminants, for example cattle, sheep, and goats, subject to pneumonic pasteurellosis. They can be administered by a variety of routes. Especially preferred is the use in animal feeds. The mutants are not reverting and contain no foreign DNA and no introduced antibiotic resistance genes.Type: GrantFiled: October 19, 2001Date of Patent: December 17, 2002Assignees: The United States of America as represented by the Secretary of Agriculture, Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 6410021Abstract: A live vaccine of recombinant mutants of a member of the family Pasteurellaceae lacking a rib gene necessary for production of riboflavin as well as a method of vaccination therewith is described. The vaccine is effective against members of the family Pasteurellaceae.Type: GrantFiled: April 22, 1998Date of Patent: June 25, 2002Inventors: Troy E. Fuller, Martha H. Mulks, Bradley Thacker
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Publication number: 20020039589Abstract: Mutants of P. haemolytica provide excellent safety and efficacy when used as vaccines in ruminants, for example cattle, sheep, and goats, subject to pneumonic pasteurellosis. They can be administered by a variety of routes. Especially preferred is the use in animal feeds. The mutants are not reverting and contain no foreign DNA and no introduced antibiotic resistance genes.Type: ApplicationFiled: October 19, 2001Publication date: April 4, 2002Inventors: Robert E. Briggs, Fred M. Tatum
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Publication number: 20020034522Abstract: A vaccine against bovine pasteurellosis due to Pasteurella haemolytica, characterised in that it comprises a first antigenic substance comprising at least one component chosen from the group consisting of:Type: ApplicationFiled: April 14, 1999Publication date: March 21, 2002Applicant: FLYNN, THIEL, BOUTELL, AND TANIS, P.C.Inventors: CHRIS ADLAM, DAMIEN SCHREUER, CATHERINE SCHUHMACHER
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Patent number: 6350454Abstract: Live-attenuated vaccines against Edwardsiella ictaluri or against Pasteurella piscicida are disclosed. Both vaccines are incapable of reversion to virulence, because both are made by deletion mutations in the aroA gene, the purA gene, or both. These vaccines may be used not only to vaccinate fish against Edwardsiella ictaluri or Pasteurela piscicida, but also to serve as vectors to present antigens from other pathogens to the fish, thereby serving as vaccines against other pathogens as well, with no risk of infection by reversion to the virulent form of the pathogen in which the antigen occurs naturally.Type: GrantFiled: October 8, 1999Date of Patent: February 26, 2002Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventor: Ronald L. Thune
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Patent number: 6331303Abstract: Mutants of P. haemolytica provide excellent safety and efficacy when used as vaccines in ruminants, for example cattle, sheep, and goats, subject to pneumonic pasteurellosis. They can be administered by a variety of routes. Especially preferred is the use in animal feeds. The mutants are not reverting and contain no foreign DNA and no introduced antibiotic resistance genes.Type: GrantFiled: September 25, 1998Date of Patent: December 18, 2001Assignee: Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 6303130Abstract: A novel vaccine for immunizing animals against Pasteurella haemolytica infection is disclosed. The vaccine is composed of whole killed cells of P. haemolytica in a dosage effective to immunize an animal against the organism, in combination with a pharmaceutically acceptable carrier. The killed cells of P. haemolytica are produced by irradiating viable cells with ultraviolet light for a sufficient period of time to kill the cells.Type: GrantFiled: November 2, 1993Date of Patent: October 16, 2001Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Charles W. Purdy, David C. Straus
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Patent number: 6180112Abstract: The present invention is directed to compositions and methods for the production for the prevention of disease due to P. haemolytica. In particular, the present invention provides P. haemolytica strains that produce inactive leukotoxin for vaccine and other uses. The present invention also provides compositions and methods for genetic manipulations in P. haemolytica.Type: GrantFiled: April 22, 1999Date of Patent: January 30, 2001Assignee: Balyor College of MedicineInventors: Sarah K. Highlander, Natalie D. Fedorova
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Patent number: RE39494Abstract: The invention relates to a method for making an inactivated vaccine of Mycoplasma hyopneumoniae by inactivating the bacteria with Thimerosal. The resulting bacterin is mixed with an adjuvant of aluminum hydroxide and DEAE dextran and injected into pigs. The resulting bacterin and adjuvant mixture can also be mixed with other bacteria such as Bordetella and Pasteurella, for further adjuvant effect. Protective immunity against mycoplasmal pneumonia is elicited in swine using these vaccines.Type: GrantFiled: August 5, 2004Date of Patent: February 27, 2007Assignee: Intervet Inc.Inventors: Gerald R. Fitzgerald, C. Joseph Welter