Eimeria Patents (Class 424/271.1)
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Patent number: 10781418Abstract: Compositions are provided that contain sporulated coccidial oocysts, wherein the compositions are free of antibiotics and comprise formalin at a concentration sufficient to inhibit microbial growth for at least 12 months while maintaining oocyst viability. Methods of preparing such compositions are also provided.Type: GrantFiled: August 26, 2019Date of Patent: September 22, 2020Assignee: HUVEPHARMA, INC.Inventors: Mary Ann Pfannenstiel, Jennifer Albrecht, Glen M. Wilkinson
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Patent number: 9302000Abstract: The present invention discloses a composition containing Arabinogalactan for enhancing the adaptive immune response in subjects to foreign antigen(s) by administering said composition prior, during and after the phase of exposure to said foreign antigen(s). Furthermore, the present invention relates to a vaccination kit comprising a composition comprising Arabinogalactan and a vaccine.Type: GrantFiled: June 9, 2014Date of Patent: April 5, 2016Inventors: Bryan Rodriguez, Kevin Q. Owen, Ulla Freitas, Jay Udani
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Patent number: 9241981Abstract: The invention relates to the use of a food additive comprising at least one phytonutrient in order to stimulate vaccine immunity against apicomplexa in non-human monogastric animals, such as poultry or pigs, or in ruminants, such as a cattle, sheep or goats.Type: GrantFiled: January 31, 2012Date of Patent: January 26, 2016Assignees: PANCOSMA S.A., THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTUREInventors: David Bravo, Hyun Lillehoj
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Patent number: 9089551Abstract: A vaccine adjuvant which, based on the 100% mass thereof, includes between 10% and 95% of a mineral oil containing: between 0.05 mass-% and 10 mass-% hydrocarbon chains having less than 16 carbon atoms, and between 0.05 mass-% and 5 mass-% hydrocarbon chains having more than 28 carbon atoms. In addition, the adjuvant has a P/N ratio, corresponding to the ratio of the mass quantity of the paraffinic hydrocarbon chains to the mass quantity of the naphthenic hydrocarbon chains, of between 2.5 and 3, the adjuvant being intended for the production of a vaccine composition to prevent coccidiosis.Type: GrantFiled: December 5, 2013Date of Patent: July 28, 2015Assignee: SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPICInventors: Laurent Dupuis, Francois Bertrand, Sebastien Deville
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Patent number: 8858959Abstract: Safe and effective gel-bead vaccines for treating domesticated birds for diseases caused by cyst-forming protozoa, especially for coccidiosis.Type: GrantFiled: July 11, 2012Date of Patent: October 14, 2014Assignee: The United States of America, as represented by the Secretary of AgricultureInventors: Mark C. Jenkins, Raymond H. Fetterer, Joseph T. Persyn
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Patent number: 8709445Abstract: This invention provides compositions for inducing an immune response in a vertebrate host against a protozoan parasite. In certain embodiments the composition comprises a protozoan parasite comprising a psoralen-modified DNA, whereby said protozoan parasite is killed but metabolically active (KBMA); and optionally a Toll-like receptor agonist.Type: GrantFiled: July 31, 2008Date of Patent: April 29, 2014Assignee: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical CenterInventors: Noah A. Craft, Kevin W. Bruhn, Ron A. Birnbaum
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Patent number: 8703154Abstract: A vaccine adjuvant which, based on the 100% mass thereof, includes between 10% and 95% of a mineral oil containing: between 0.05 mass-% and 10 mass-% hydrocarbon chains having less than 16 carbon atoms, and between 0.05 mass-% and 5 mass-% hydrocarbon chains having more than 28 carbon atoms. In addition, the adjuvant has a P/N ratio, corresponding to the ratio of the mass quantity of the paraffinic hydrocarbon chains to the mass quantity of the naphthenic hydrocarbon chains, of between 2.5 and 3, the adjuvant being intended for the production of a vaccine composition to prevent coccidiosis.Type: GrantFiled: January 14, 2011Date of Patent: April 22, 2014Assignee: Societe d'Exploitation de Produits pour les Industries Chimiques SEPPICInventors: Laurent Dupuis, Francois Bertrand, Sebastien Deville
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Publication number: 20140086956Abstract: A vaccine adjuvant which, based on the 100% mass thereof, includes between 10% and 95% of a mineral oil containing: between 0.05 mass-% and 10 mass-% hydrocarbon chains having less than 16 carbon atoms, and between 0.05 mass-% and 5 mass-% hydrocarbon chains having more than 28 carbon atoms. In addition, the adjuvant has a P/N ratio, corresponding to the ratio of the mass quantity of the paraffinic hydrocarbon chains to the mass quantity of the naphthenic hydrocarbon chains, of between 2.5 and 3, the adjuvant being intended for the production of a vaccine composition to prevent coccidiosis.Type: ApplicationFiled: December 5, 2013Publication date: March 27, 2014Applicant: SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPICInventors: Laurent DUPUIS, Francois BERTRAND, Sebastien DEVILLE
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Publication number: 20130017220Abstract: Safe and effective gel-bead vaccines for treating domesticated birds for diseases caused by cyst-forming protozoa, especially for coccidiosis.Type: ApplicationFiled: July 11, 2012Publication date: January 17, 2013Inventors: Mark C. Jenkins, Raymond H. Fetterer, Joseph T. Persyn
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Publication number: 20120308604Abstract: A vaccine adjuvant which, based on the 100% mass thereof, includes between 10% and 95% of a mineral oil containing: between 0.05 mass-% and 10 mass-% hydrocarbon chains having less than 16 carbon atoms, and between 0.05 mass-% and 5 mass-% hydrocarbon chains having more than 28 carbon atoms. In addition, the adjuvant has a P/N ratio, corresponding to the ratio of the mass quantity of the paraffinic hydrocarbon chains to the mass quantity of the naphthenic hydrocarbon chains, of between 2.5 and 3, the adjuvant being intended for the production of a vaccine composition to prevent coccidiosis.Type: ApplicationFiled: January 14, 2011Publication date: December 6, 2012Applicant: SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPICInventors: Laurent Dupuis, Francois Bertrand, Sebastien Deville
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Patent number: 8257714Abstract: The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in a subject, and for use as an alternative to interleukin-12 (IL-12) treatment. In particular, the present invention provides Apicomplexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of cancer and infectious diseases and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of cancer and/or infectious diseases, for use as an alternative to interleukin-12 (IL-12) treatment, and for eliciting an immune response in a subject, are also provided.Type: GrantFiled: April 14, 2008Date of Patent: September 4, 2012Assignee: Michigan State UniversityInventors: Charles Aylsworth, Siu-Cheong Ho, David Juckett, John W. Judge, Barnett Rosenberg, Igor V. Zlatkin, Tatiana Zlatkin
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Patent number: 8110188Abstract: The invention refers to anticoccidial compositions consisting mainly of yolk immunoglobulins derived from eggs of hens immunized with one or more Eimeria species. The invention refers also to the use of said anticoccidial compositions for prevention or treatment of coccidiosis. The administration of immunoglobulins, both in liquid as well as in powder or pellet presentation, decreases mortality, lesions, oocysts counts and increases weight gain of receiving animals.Type: GrantFiled: September 30, 2005Date of Patent: February 7, 2012Assignee: Investigacion Aplicada, S.A. de C.V.Inventors: Jose Andres Morales Garzon, Eduardo Lucio Decanini
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Publication number: 20110217333Abstract: The present invention is directed to a method of treating poultry hatchlings in a hatchling tray. The method comprises of providing a soft gel form capable of being dispensed through a spray nozzle, providing a spray dispensing apparatus, the apparatus being capable of delivering a predetermined volume of the gel as a plurality of small beadlets through a plurality of nozzles, placing the hatchling tray containing the hatchlings beneath the nozzles of the dispensing apparatus, dispensing the predetermined volume of the soft gel containing the therapeutic agent as small beadlets into the hatchling tray and allowing the hatchlings to consume the beadlets. The present invention is also directed to a dispensing apparatus for dispensing a therapeutic agent in a soft gel into a hatchling tray of poultry hatchlings.Type: ApplicationFiled: May 11, 2011Publication date: September 8, 2011Inventor: Eng-Hong Lee
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Patent number: 7968695Abstract: The present invention provides the recombinant cloning and sequencing of two of the major Eimeria maxima gametocyte antigens having molecular weights of 56 and 82 kDa and the expression of these recombinant antigens in an E. coli expression system using the plasmid pTrcHis. The subject invention also provides a vaccine against coccidiosis comprising the recombinant 56 kDa or 82 kDa antigen. The subject invention also provides two 30 kDa proteins and three 14 kDa proteins from Eimeria maxima gametocytes having at the N-terminal end the amino acid sequence described herein. The subject invention also provides a vaccine against coccidiosis comprising the recombinant 56 kDa or 82 kDa antigen and any of the aforementioned proteins.Type: GrantFiled: May 30, 2008Date of Patent: June 28, 2011Assignee: Abic Biological Laboratories Ltd.Inventors: Sabina I. Belli, Nicholas C. Smith, Michael Wallach
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Publication number: 20110111015Abstract: Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD 154 polypeptide capable of binding to CD4Q. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.Type: ApplicationFiled: November 3, 2008Publication date: May 12, 2011Inventors: Walter Bottje, Billy Hargis, Luc Berghman, Young Min Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton, Said El-Ashram, John Barta, Guillermo Tellez
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Publication number: 20110091526Abstract: Compositions and methods for the development and use of a vaccine that includes one or more FusM antigens in a carrier adapted to trigger a FusM-specific immune response in the human blood stream are disclosed herein.Type: ApplicationFiled: October 6, 2010Publication date: April 21, 2011Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, IMPERIAL COLLEGE OF LONDONInventors: William J. Snell, Yanjie Liu, Oliver Billker, Robert E. Sinden, Rita Tewari
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Patent number: 7879342Abstract: The present invention relates to a novel adjuvant and/or immunomodulator isolated from peanut skin extract, which may be useful in the preparation of immunogenic compositions and vaccines. The present invention also provides for a method of stimulating acquisition of protective immunity by administering peanut skin extract prior to vaccination.Type: GrantFiled: March 14, 2005Date of Patent: February 1, 2011Assignee: Univ. of Georgia Research Foundation, Inc.Inventors: Larry R. McDougald, Alberta Lorraine Fuller
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Publication number: 20100310606Abstract: This invention provides compositions for inducing an immune response in a vertebrate host against a protozoan parasite. In certain embodiments the composition comprises a protozoan parasite comprising a psoralen-modified DNA, whereby said protozoan parasite is killed but metabolically active (KBMA); and optionally a Toll-like receptor agonist.Type: ApplicationFiled: July 31, 2008Publication date: December 9, 2010Applicant: LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTERInventors: Noah A. Craft, Kevin W. Bruhn, Ron A. Birnbaum
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Patent number: 7846685Abstract: Methods are provided for the sporulation, sterilization and storage of coccidial oocyst which are characterized by an absence of the highly toxic chemical potassium dichromate. Also provided are compositions containing sporulated oocysts which are free of potassium dichromate.Type: GrantFiled: March 12, 2004Date of Patent: December 7, 2010Assignee: Novus International, Inc.Inventors: Charles S. Schasteen, Jackie Green, Lance Bull, Farooq Uraizee, Mary Ann Pfannenstiel, Tony Allington, Steven J. Mueller
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Publication number: 20100183668Abstract: The present invention provides a novel use of coccidian, specifically relates to the use of coccidian as a vaccine live vector. The present invention further provides a live vaccine with coccidian as a vector, which is transgenic coccidian capable of expressing exogenous protein or stably transfected coccidian that contain expression vector and can express exogenous coccidian. The present coccidian vector live vaccine can induce organisms to simultaneously generate protective humoral and cellular immune responses (including the mucosal immune response), as well as generate memory responses, which can be readily carried out and has stable effect and high biological safety without generating immune tolerance.Type: ApplicationFiled: March 28, 2008Publication date: July 22, 2010Inventors: Xun Suo, Xiaojia Wang, Xianyong Liu, Tuanyuan Shi, Lili Hao, Wenchao Yan, Hongyan Wang, Jianan Li
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Publication number: 20100166803Abstract: The present invention discloses a vaccine that provides protection to turkeys from coccidiosis, and methods of making and using the vaccine alone, or in combinations with other protective agents. In addition, the present invention discloses PCR primer sets that are useful in identifying the species of Eimeria in a biological sample.Type: ApplicationFiled: November 11, 2009Publication date: July 1, 2010Inventors: Steve Hewart Fitz-Coy, Gamini Saman Kumara Withanage, Alexandria Louise McGowan, Stephanie M. Cook
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Publication number: 20100040615Abstract: The invention relates to a digalactolipidic antigen exposed on the surface of apicomplex parasites, in the form of a vegetable-type digalactoglycerolipid, and adapted for inducing the production of specific antibodies capable of inhibiting the proliferation and/or the invasive properties of said parasites; the invention also relates to a derived antibody or functional antibody fragment, and to their diagnostic, immunotherapeutic and vaccine applications in human beings or animals.Type: ApplicationFiled: February 7, 2008Publication date: February 18, 2010Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE, CENTRE NATIONAL DE LA RECHERCHE SEIENTIFIQUEInventors: Cyrille Botte, Nadia Saidani, Maryse Block, Jean-Francois Dubremetz, Henri Vial, Marie-France Cesbron-Delauw, Corinne Mercier, Eric Marechal
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Publication number: 20100015182Abstract: The present invention discloses a vaccine that provides protection from coccidiosis, and methods of making and using the vaccine alone, or in combination with other protective agents.Type: ApplicationFiled: May 27, 2009Publication date: January 21, 2010Inventors: Marcelo Lang, Charles Timothy Broussard, Joan S. Schrader
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Patent number: 7638131Abstract: This invention relates to novel Eimeria proteins with immunogenic properties as well as to DNA sequences encoding these proteins. These proteins can be administered to poultry thereby protecting the birds against coccidiosis. In addition the DNA encoding these proteins can be used for the preparation of a vector vaccine against coccidiosis.Type: GrantFiled: May 2, 2007Date of Patent: December 29, 2009Assignee: Intervet International B.V.Inventors: Jacobus Johannes Kok, Paul van den Boogaart, Arnodus Nicolaas Vermeulen
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Methods of treating or preventing a disease, disorder or condition associated with a viral infection
Patent number: 7550150Abstract: The present invention relates to methods of treating or preventing a disease, disorder or condition associated with a viral infection using a dosing and resting regimen for administering a pharmaceutical composition that provides ARP.Type: GrantFiled: March 14, 2006Date of Patent: June 23, 2009Assignee: Barros Research InstituteInventors: Barnett Rosenberg, John W. Judge -
Patent number: 7462707Abstract: The present invention provides an isolated nucleic acid comprising a nucleotide sequence encoding a 250 kDa polypeptide from Sporozoites/Merozoites of Eimeria maxima, or encoding a homolog of the polypeptide, or a complement of the nucleic acid and a method of producing a recombinant 250 kDa polypeptide of the same. The present invention also provides an isolated nucleic acid comprising a nucleotide sequence encoding an immunodominant portion of a 250 kDa polypeptide from Sporozoites/Merozoites of Eimeria maxima having the amino acid sequence described herein, or encoding a homolog of the polypeptide, or a complement of the nucleic acid.Type: GrantFiled: July 3, 2002Date of Patent: December 9, 2008Assignees: University of Technology, Sydney, Abic Biological Laboratories Teva, Ltd.Inventors: David Witcombe, Nicholas C. Smith, Michael Wallach
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Publication number: 20080241075Abstract: The present invention includes compositions and methods for the development and use of a vaccine that includes one or more FusM antigens in a carrier adapted to trigger a FusM-specific immune response in the human blood stream.Type: ApplicationFiled: September 15, 2007Publication date: October 2, 2008Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, IMPERIAL COLLEGE OF LONDONInventors: William Snell, Yanjie Liu, Robert Sinden, Oliver Billker
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Patent number: 7423137Abstract: The present invention provides the recombinant cloning and sequencing of two of the major Eimeria maxima gametocyte antigens having molecular weights of 56 and 82 kDa and the expression of these recombinant antigens in an E. coli expression system using the plasmid pTrcHis. The subject invention also provides a vaccine against coccidiosis comprising the recombinant 56 kDa or 82 kDa antigen. The subject invention also provides two 30 kDa proteins and three 14 kDa proteins from Eimeria maxima gametocytes having at the N-terminal end the amino acid sequence described herein. The subject invention also provides a vaccine against coccidiosis comprising the recombinant 56 kDa or 82 kDa antigen and any of the aforementioned proteins.Type: GrantFiled: July 3, 2002Date of Patent: September 9, 2008Assignee: Abic Biological Laboratories Teva, Ltd.Inventors: Sabina I. Belli, Nicholas C. Smith, Michael Wallach
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Publication number: 20080131463Abstract: A method for protecting fowl against coccidiosis includes the steps of inoculating the fowl with coccidial oocysts from a strain of Eimeria that is at least partially resistant to an ionophore and subsequently administering to the fowl the ionophore and at least one chemotherapeutic anticoccidial agent. In particular, the ionophore is administered in stages both before and after the administration of the at least on chemotherapeutic agent. In a preferred embodiments, the method provides protection from coccidiosis without administration of antibiotics to the fowl and without continued administration of agents throughout the life of the fowl.Type: ApplicationFiled: November 30, 2006Publication date: June 5, 2008Applicant: Perdue Holdings, Inc.Inventors: Bruce Stewart-Brown, Henry M. Engster, Douglas K. Marvil
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Patent number: 7247309Abstract: The present invention relates to coccidia strains and, in one embodiment, to microbiological cultures comprising such strains. In preferred embodiments, the coccidia strains are selected for tolerance to one group of coccidiostatic drugs, sensitivity to a second group of coccidiostatic drugs, and decreased proliferative capacity. Another embodiment of the invention relates to vaccines based on the coccidia strains according to the invention.Type: GrantFiled: December 18, 2000Date of Patent: July 24, 2007Assignee: Intervet International B.V.Inventors: Arnoldus Nicolaas Vermeulen, Theodorus Petrus Maria Schetters
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Patent number: 7230075Abstract: This invention relates to novel Eimeria proteins with immunogenic properties as well as to DNA sequences encoding these proteins. These proteins can be administered to poultry thereby protecting the birds against coccidiosis. In addition the DNA encoding these proteins can be used for the preparation of a vector vaccine against coccidiosis.Type: GrantFiled: September 14, 1999Date of Patent: June 12, 2007Assignee: Intervet International B.V.Inventors: Jacobus Johannes Kok, Paul van den Boogaart, Arnodus Nicolaas Vermeulen
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Patent number: 7211265Abstract: Vaccines for the prevention and/or treatment of Eimeria infection including one or more strains of E. maxima ARI-73/97, E. acervulina ARI-77/97, E. tenella ARI-11/98, E. necatrix MCK01 and/or E. necatrix ARI-MEDNEC3+8 are described. Eimeria selected from E. maxima ARI-73/97, E. acervuina ARI-77/97, E. tenella ARI-11/98, E. necatrix MCK01 and/or E. mecatrix ARI-MEDNEC3+8 are also described.Type: GrantFiled: May 10, 2004Date of Patent: May 1, 2007Assignees: Eimeria Pty. Limited, The State of Queensland through the Department of Primary Industries, Rural Industries Research and Development CorporationInventors: David Grant Richards, Wayne Keith Jorgensen, Norman Porter Stewart
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Patent number: 7018640Abstract: The invention relates to a method of vaccinating a domesticated bird against coccidiosis comprising administering in ovo an effective immnunizing dose of live Eimeria sporozoites or merozoites, or a mixture thereof. In a preferred embodiment, the domesticated bird that is vaccinated is a chicken or turkey.Type: GrantFiled: March 8, 2002Date of Patent: March 28, 2006Assignee: Pfizer IncorporatedInventors: Nigel A. Evans, Robert Craig Findly, Frederick H. Weber
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Patent number: 7008632Abstract: The present invention relates to compositions comprising sporocysts of at least one parasitic single-cell organism and at least one anticoagulant, and to their use for controlling harmful rodents.Type: GrantFiled: January 5, 2001Date of Patent: March 7, 2006Assignee: Bayer AktiengesellschaftInventors: Gerhard Hesse, Thomas Böcker, Stefan Endepols, Thomas Jäkel, Sermasakdi Hongnark
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Patent number: 6994861Abstract: The present invention provides attenuated live cultures of the pathogenic protozoan parasite, Neospora, and live vaccines against neosporosis prepared therefrom which are useful in the prevention of clinical disease and abortion in mammals.Type: GrantFiled: September 24, 2003Date of Patent: February 7, 2006Assignee: Pfizer IncInventors: David A Brake, Byron L Blagburn, David S Lindsay
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Patent number: 6969602Abstract: An immunovariant strain of Eimeria maxima was isolated. Vaccines incorporating the immunovariant strain are effective in eliciting immunological protection against coccidial infection.Type: GrantFiled: April 20, 2001Date of Patent: November 29, 2005Assignees: The United States of America as represented by the Secretary of the Agriculture, University of GuelphInventors: Harry D. Danforth, M. Aggie Fernando, John R. Barta
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Patent number: 6890527Abstract: A method of producing active immunity against a bacterial or protozoal disease in a subject comprises administering to the subject a vaccine conjugate comprising a live bacteria or protozoa and a neutralizing factor bound to the live bacteria or protozoa. The neutralizing factor is selected from the group consisting of antibodies and antibody fragments. The live bacteria or protozoa is one capable of producing disease in the subject, and the antibody or antibody fragment is one capable of neutralizing the live bacteria or protozoa.Type: GrantFiled: May 24, 2002Date of Patent: May 10, 2005Assignee: The University of ArkansasInventors: John A. Thoma, Eid E. Haddad, Craig E. Whitfill, Alan P. Avakian
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Patent number: 6790937Abstract: The present invention relates to (a) variable regions of heavy and light chains of an antibody specific to a surface antigen in sporozoite of Eimeria spp.; (b) a recombinant scFV (single chain variable fragment) antibody prepared using the variable regions; (c) a method for preparing a recombinant scFv antibody; and (d) an expression vector for expressing a recombinant scFv antibody.Type: GrantFiled: February 26, 2002Date of Patent: September 14, 2004Assignee: Avicore Biotechnology Institute Inc.Inventors: Jin-Kyoo Kim, Jae-Yong Han, Ki-Duck Song, Sung-Won Kim, Won-Gi Min, Eun-Jung Son, Hyun Soon Lillehoj, Erik Peter Lillehoj
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Patent number: 6767546Abstract: Echinacea dietary supplements are useful adjuvants for live anticoccidial vaccines. Feed supplementation with Echinacea preparations enhances the immune response to such vaccines. Echinacea purpurea in amounts of about 0.1% to 0.5% administered for about two weeks to day-old chicks has been found effective for providing significant weight gain compared to vaccination alone.Type: GrantFiled: August 17, 2001Date of Patent: July 27, 2004Assignees: The United States of America as represented by the Secretary of Agriculture, Triarco Industries, Inc.Inventors: Patricia C. Allen, Mark Anderson, Harry D. Danforth
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Publication number: 20040132178Abstract: The cloning of a novel PCVII viral genome is described as is expression of proteins derived from the PCVII genome. These proteins can be used in vaccine compositions for the prevention and treatment of PCVII infections, as well as in diagnostic methods for determining the presence of PCVII infections in a vertebrate subject. Polynucleotides derived from the viral genome can be used as diagnostic primers and probes.Type: ApplicationFiled: September 2, 2003Publication date: July 8, 2004Inventors: Deborah Haines, Gordon Allan, John Ellis, Brian Meehan, Edward Clark, Lori Hassard, John Harding, Catherine Elisabeth Charreyre, Gilles Emile Chappuis, Francis McNeilly, Li Wang, Lorne A. Babiuk, Andrew A. Potter, Philip Willson
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Patent number: 6656479Abstract: The present invention provides attenuated live cultures of the pathogenic protozoan parasite, Neospora, and live vaccines against neosporosis prepared therefrom which are useful in the prevention of clinical disease and abortion in mammals.Type: GrantFiled: September 12, 2001Date of Patent: December 2, 2003Assignee: Pfizer Inc.Inventors: David A Brake, Byron L Blagburn, David S Lindsay
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Patent number: 6627205Abstract: The invention relates to a method of vaccinating a domesticated bird against coccidiosis comprising administering in ovo an effective immunizing dose of live Eimeria sporocysts or oocysts, or a mixture thereof.Type: GrantFiled: March 8, 2002Date of Patent: September 30, 2003Assignee: Pfizer IncorporatedInventors: Nigel A. Evans, Robert Craig Findly, Frederick H. Weber
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Publication number: 20030175311Abstract: This invention provides DNA sequences coding for Eimeria surface antigens, recombinant vectors containing such DNA sequences, transformed microorganisms containing such vectors and methods for producing the antigens using the transformed microorganisms. Methods are also provided for protecting poultry against coccidiosis using the Eimeria surface antigens. The surface antigens can be administered for such protection either as purified proteins or in the form of DNA encoding the proteins in a suitable viral vector such as vaccinia virus.Type: ApplicationFiled: October 9, 2002Publication date: September 18, 2003Applicant: ALPHARMA INC.Inventors: Mary-Helen Binger, Richard Anthony Chizzonite, Richard Allen Kramer, Peter Thomas Lomedico, Stephen J. McAndrew, Werner Altenburger
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Patent number: 6500438Abstract: The invention relates to a method of vaccinating a domesticated bird against coccidiosis comprising administering in ovo an effective immunizing dose of live Eimeria sporozoites or merozoites, or a mixture thereof. In a preferred embodiment, the domesticated bird that is vaccinated is a chicken or turkey.Type: GrantFiled: December 1, 1997Date of Patent: December 31, 2002Assignee: Pfizer IncorporatedInventors: Nigel A. Evans, Robert Craig Findly, Frederick H. Weber
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Patent number: 6495146Abstract: The invention relates to a method of vaccinating a domesticated bird against coccidiosis comprising administering in ovo an effective immunizing dose of live Eimeria sporocysts or oocysts, or a mixture thereof.Type: GrantFiled: December 1, 1997Date of Patent: December 17, 2002Assignee: Pfizer IncorporatedInventors: Nigel A. Evans, Robert Craig Findly, Frederick H. Weber
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Publication number: 20010005910Abstract: The present invention relates to coccidiosis strains and, in another embodiment to microbiological cultures comprising such strains. Another embodiment of the invention relates to vaccines based thereon. Still other embodiments relate to the use of such strains for the preparation of vaccines for the protection against coccidiosis and to methods for the preparation of such vaccines.Type: ApplicationFiled: December 18, 2000Publication date: June 28, 2001Inventors: Arnoldus Nicolaas Vermeulen, Theodorus Petrus Maria Schetters
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Patent number: 6203801Abstract: The present invention relates to hydrophilic Eimeria polypeptides, DNA-fragments encoding those peptides, recombinant DNA molecules comprising such DNA-fragments, live recombinant carriers comprising such DNA-fragments or recombinant DNA molecules and host cells comprising such DNA-fragments, recombinant DNA molecules or live recombinant carriers. Furthermore, the invention relates to antibodies against the polypeptides and to coccidiosis vaccines based upon said polypeptides. The invention also relates to methods for the preparation of such antibodies and vaccines, and to methods for the detection of Eimeria parasites and antibodies against Eimeria parasites.Type: GrantFiled: October 4, 1999Date of Patent: March 20, 2001Assignee: Akzo Nobel N.V.Inventors: Theodorus Cornelis Schaap, Catharina Maria Kuiper, Arnoldus Nicolaas Vermeulen