Abstract: Present invention relates to a method and composition for symptomatic relief of vaginitis. Until the treatment of underlying cause takes effect women suffer from unpleasant symptoms of vaginitis restricting daily routine activities. The symptoms of vaginitis may be incapacitating and are a common reason for visiting the gynecologist and can lead to frustration, embarrassment, anger, lost days from work, marital conflict and loss of ability to enjoy a normal personal, professional and social life.

Abstract: Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce peptides free of contaminants derived from bacteria normally containing the Tbp1 or Tbp2 proteins for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection. Also provided are recombinant Tbp1 or Tbp2 and methods for purification of the same. Live vectors expressing epitopes of transferrin receptor protein for vaccination are provided.

Abstract: Wound care devices having a topically applied silver-based antimicrobial finish are provided. The finish comprises at least one silver ion-containing compound and at least one binder compound. The finish may be applied to a target substrate, such as a fiber, fabric, film, foam, hydrogel, or hydrocolloid to provide a single layer antimicrobial wound care device. Alternatively, a silver-containing layer may be combined with one or more additional layers of target substrate to provide a composite antimicrobial wound care device. The device may also contain an odor-absorbing component capable of reducing or eliminating odors that are inherently associated with infectious wounds. Also provided is a method for making the wound care device and a composition of matter comprising the silver-based antimicrobial finish.

Abstract: Effective amounts of the inhibitory compounds described herein capable of significantly reducing the production of TSST-1 are as follows: (1) compounds of Structure (I): from about 0.0001 micromoles/gram absorbent product to about 0.08 micromoles/gram absorbent product, desirably from about 0.0005 micromoles/gram of absorbent product to about 0.05 micromoles/gram of absorbent product; and (2) compounds of Structures (II) and (III): from about 0.05 micromoles/gram of absorbent product to 5 micromoles/gram of absorbent product, desirably from about 0.1 micromoles/gram of absorbent product to about 1 micromole/gram of absorbent product. Specifically, effective amounts of hexachlorophene include from about 0.00024 micromoles/gram of absorbent product to about 0.08 micromoles/gram of absorbent product, desirably from about 0.001 micromoles/gram of absorbent product to about 0.05 micromoles/gram of absorbent product. Specifically, effective amounts of triclosan include from about 0.

Abstract: A soothing anti-viral lotion composition and a lotioned tissue product having a surface with the lotion composition applied thereto, and methods for making and using the same. The lotion composition includes an anti-viral organic acid and a topical delivery system. The topical delivery system includes one or more polyesters which allow incorporation of the organic acids into the lotion formulation, controls their delivery, and maintains them in the stratum corneum. The lotion composition may optionally contain a surfactant, an irritation inhibiting agent, and other additives.

Abstract: The invention relates to the use of one or more antimicrobial metals preferably selected from silver, gold, platinum, and palladium but most preferably silver, formed with atomic disorder, and preferably in a nanocrystalline form, for reducing inflammation or infection of the mucosal membrane. The antimicrobial metal may be formulated as, or used in the form of, a nanocrystalline coating of one or more antimicrobial or noble metals, a nanocrystalline powder of one or more antimicrobial or noble metals, or a liquid or solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial or noble metals.

Abstract: A white cream bacteriostat and fungicide capable of serving as a vehicle for additional medicaments. Also disclosed is a method for blending the ingredients, some of which are not readily compatible with each other.

Abstract: A topical sustained release delivery system for delivery of antifungal agents to the finger or toenails achieving high penetration through the nails by combining the antifingal agent with a keratolytic agent and a humectant. The pharmaceutical sustained release topical preparation is provided in a varnish or spray form for treating the nail and surrounding tissues, where the active ingredient is an antifungal agent, a keratolytic agent, or preferably a combination of an antifuingal and a keratolytic agent. The composition may further comprise an antibacterial, an antiviral, an antipsoriatic agents, or combinations thereof.

Abstract: A disinfectant delivery system and method of providing alcohol-free disinfection to a body to be disinfected, as well as a method of infection reduction by preparation of a patient before an invasive procedure. A blended cloth comprising first fibers and second fibers is provided with the first fibers generally being greater in quantity by weight than the second fibers. A disinfectant solution impregnates the blended cloth, with the disinfectant solution having chlorhexidine gluconate as an active ingredient and having no alcohol. In the method according to the invention, at least one impregnated blended cloth is used to disinfect at least a portion of a body. A plurality of blended cloths can be provided for disinfecting discrete portions of the body.

Abstract: Concentrated vapors from botanical essential oils are inhaled to prevent, treat and cure infections of the respiratory pathogens causing Severe Acute Respiratory Syndrome (“SARS”). These vapors are inhaled as a practical method to reduce the risks of infection by the pathogens causing SARS in crowded public places. These vapors are also inhaled as a practical method to reduce the risks of infection by unknown, and unpredictable, respiratory pathogens that may be present in public places. The essential oils have antiseptic properties, are safe to inhale, and include, but are not limited to, the essential oils from Eucalyptus globulus, Melaleuca alternifolia, Eucalyptus citriodora, and Eucalyptus radiata. Convenient hand-held inhaler apparatus are provided for the inhalation of concentrated vapors from the antiseptic essential oils and other substances. The antiseptic essential oils have selected antiviral, antibacterial, and antifungal properties.

Abstract: The present invention relates to a composition comprising a) at least one antimycotic agent and b) at least one film forming agent wherein component b) is a derivative of chitosan selected from hydroxyalkylchitosans and carboxyalkylchitosans and its use as a nail varnish. The present invention is further directed to the use of a water soluble film forming agent selected from hydroxyalkylchitosans and carboxyalkylchitosans as an additive in a nail varnish.

Abstract: Water-in-oil emulsions, compositions, and methods that include a vinyl polymer that includes ethylene oxide-containing side chains and alkyl-Y-containing side chains, wherein Y is O or NR, wherein R is H or CH3, and wherein the alkyl group of the alkyl-Y-containing side chain has at least 4 carbon atoms on average in a cyclic, branched-, or straight-chain configuration and optionally including one or more heteroatoms.

Abstract: Non-absorbent articles are disclosed. The non-absorbent articles include an effective amount of an aromatic inhibitory compound to substantially inhibit the production of exotoxins by Gram positive bacteria. The aromatic inhibitory compounds of the present invention have the general formula: wherein R1 is selected from the group consisting of H, —OR5, —R6C(O)H, —R6OH, —R6COOH, —OR6OH, —OR6COOH, —C(O)NH2, and NH2 and salts thereof; R5 is a monovalent saturated or unsaturated aliphatic hydrocarbyl moiety; R6 is a divalent saturated or unsaturated aliphatic hydrocarbyl moiety; R7 is a trivalent saturated or unsaturated aliphatic hydrocarbyl moiety; R8 is a monovalent substituted or unsubstituted saturated or unsaturated aliphatic hydrocarbyl moiety which may or may not be interrupted with hetero atoms; R2, R3, and R4 are independently selected from the group consisting of H, OH, COOH, and —C(O)R9; R9 is hydrogen or a monovalent saturated or unsaturated aliphatic hydrocarbyl moiety.

Abstract: A pharmaceutical preparation comprising a hydrophilic gel-forming agent, water and a compound of the formula I is suitable for the treatment and prophylaxis of dermatomycoses.

Abstract: The invention relates to the use of one or more antimicrobial metals selected from silver, gold, platinum, and palladium but most preferably silver, preferably formed with atomic disorder, and preferably in a nanocrystalline form, for the treatment of a acne. The nanocrystalline antimicrobial metal of choice may be used in the form of a nanocrystalline coating of one or more antimicrobial metals, a nanocrystalline powder of one or more antimicrobial metals, or a solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial metals.

Abstract: The invention relates to a method to induce apoptosis and to inhibit matrix metalloproteinases in a disease condition in a human or animal by contacting hyperplastic tissue, tumor tissue, or a cancerous lesion with one or more antimicrobial metals, preferably formed with atomic disorder, and preferably in a nanocrystalline form. In another aspect of the invention, there is provided a method of preventing excessive release of matrix metalloproteinases from an inflammatory cell in a disease condition in a human or an animal by contacting the cell with a therapeutically effective amount of a noble metal in a crystalline form characterized by atomic disorder, or with a solution derived therefrom to provide a modulatory effect on one or more matrix metalloproteinases, wherein the one or more noble metals is formed with atomic disorder, and preferably in a nanocrystalline form.

Abstract: The present invention is directed to ion triggerable, water-dispersible cationic polymers. The present invention is also directed to a method of making ion triggerable, water-dispersible cationic polymers and their applicability as binder compositions. The present invention is further directed to fiber-containing fabrics and webs comprising ion triggerable, water-dispersible binder compositions and their applicability in water-dispersible personal care products, such as wet wipes.

Abstract: Therapeutic treatments using the direct application of selected structures of antimicrobial metals in free-standing powder form, solution form and/or suspension form in therapeutically effective amounts. The selected structures of antimicrobial metals serve as an antimicrobial agent, an anti-inflammatory agent, an immuno modulator agent, an enzyme modulator agent, and/or an anti-tumor agent, for human and/or animal use.

Abstract: The invention concerns an anti-microbial porous part based on a polymeric material grafted at the surface and in its volume with ammonium motifs with anti-microbial and/or bactericidal and/or fungicide activity, preferably benzalkonium. The invention is characterized in that it has a porosity sufficiently high to enable a liquid with compatible viscosity to pass through its structure and sufficiently low to trap contaminating germs within said structure.

Abstract: This invention relates to a topical spray preparation for burn treatment and microbial infections on human being or animals. This non-aerosol preparation contains an antimicrobial drug, i.e., silver sulfadiazine, as is dispersed or solubilized in a cream or lotion base matrix which can be sprayed directly from a common trigger spray device. The key component of the matrix can be characterized by it having a suitable molecular weight polymer of cross-linked acrylic acid, such as Carbomers or non-ionic surfactants such as polyoxyethylene alkyl ethers, or any combination of the above materials.

Abstract: An alcohol-free antibacterial wipe comprising a flexible fabric coated with a polymeric latex binder, and an aqueous antibacterial solution wherein the aqueous antibacterial solution is comprised of an effective amount of a cationic antibacterial agent and sufficient amount of a surfactant.

Abstract: The present invention provides a yarn with antimicrobial effects. The antimicrobial antifungal effect of the yarn is derived from nanosilver particles (diameter between 1 and 100 nm) which are adhered to the yarn. The yarn contains fibers which are made of cotton, linen, silk, wool, leather, blending fabric, synthetic fiber, or any combination thereof. The yarn can be used to make cloth to be used particularly for treating patients with burns or wound. The cloth made from the antimicrobial yarn can be further used to make clothes such as underwears, socks, shoe cushions, shoe linings, bed sheets, pillow cases, towels, women hygiene products, laboratory coats, and medical robes. The present invention also provides a method for making the antimicrobial yarn.

Abstract: A chewable, biodegradable article for use as a pet toy comprises a matrix made of a natural polymer, a synthetic organic polymer or a mixture thereof, a natural or synthetic fibrous material that comprises fibers and that is bonded chemically or physically with the matrix material, and, optionally, includes one or more microbe inhibiting agents that inhibit the growth of microbes in or on the article. The presence of the fibrous material inhibits formation of sharp edges upon breakage when the article is chewed, thereby rendering the article safer when used by pets. Also disclosed are processes for manufacturing the above article.

Abstract: An antifungal fragrance composition containing as its active ingredients: (a) at least one type of fragrance component selected from the group consisting of an aliphatic or aromatic aldehyde having 5 to 16 carbon atoms and an aliphatic or aromatic alcohol having 5 to 16 carbon atoms, and (b) at least one type of compound different from component (a) and selected from the group consisting of an aliphatic or aromatic aldehyde, an aliphatic or aromatic alcohol, acetal and ester that produces synergistic antifungal effects in the presence of said fragrance component (a). The present antifungal fragrance composition demonstrates antifungal activity by adding a small amount of oils and fragrant chemical products that have a minimal effect on the scent of the fragrance composition.

Abstract: A compound of formula wherein Y represents a pyridyl group, or a phenyl group of formula wherein R3 represents a hydrogen atom, a CF3 group or an alkoxy group, R4 represents a hydrogen atom, an alkyl group, or a CF3 group, R5 represents a hydrogen atom, an alkyl group, a CF3 group or an alkoxy group, and R1 and R2 are the substituents of a terminal alkene of formula wherein R1 represents an alkyl or alkylene group, a mono- or poly-cycloalkyl group, or a phenyl group that optionally includes one or several hetero-atoms of oxygen, nitrogen, phosphorous or sulfur; R2 represents a hydrogen atom, an alkyl or alkylene group, a mono- or poly-cycloalkyl group, or a phenyl group that optionally includes one or several hetero-atoms of oxygen, nitrogen, phosphorous and sulfur.

Abstract: The invention relates to the use of one or more antimicrobial metals, most preferably silver, preferably formed with atomic disorder, and preferably in a nanocrystalline form, for the treatment of inflammatory skin conditions. The nanocrystalline antimicrobial metal of choice may be used in the form of a nanocrystalline coating of one or more antimicrobial metals, a nanocrystalline powder of one or more antimicrobial metals, or a solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial metals.

Abstract: The present invention relates to new silver-ion super-complex compositions. More particularly, the present invention describes silver-ion super-complex compositions comprising a silver-thiosulfate ion complex further complex with a primary, secondary or tertiary amine. These silver-ion super-complex compositions are stable in a saline environment and have improved solvent miscibility.

Abstract: A wiper having a controlled release anti-microbial agent therein for providing anti-microbial cleansing of surfaces is provided. The wiper is formed from an absorbent base web to which an anti-microbial formulation is adhered. The formulation includes an anti-microbial agent that is capable of being controllably released from the wiper. In some embodiments, a polymer mixture may be employed to control the rate of release of the anti-microbial agent. Various anti-microbial agents, such as metal ions and organic compounds may be employed.

Abstract: The invention relates to an active substance vector multiparticulate system and to the production and use thereof. The object of the invention is an active-substance vector multiparticulate system comprising one or several active substances included in a hydrophilic organic matrix comprising at least one hydrosoluble and/or hydrodispersable anionic polymer which is insolubilized by a metallic cation. The invention can be specifically used in the food industry, detergents and agrochemistry.

Abstract: The present invention provides a multiple, long-term use, antimicrobial glove. The glove is formed from one or more layers of material having a latex-based matrix with an antimicrobial agent, such as diiodomethyl-p-tolylsulfone, homogeneously incorporated therein. Optionally, the glove may also have additional antimicrobial agents incorporated therein. The glove of the present invention is capable of inhibiting molds and other microbes from proliferating on any surface of the glove, during both storage and use, which results in the prevention of malodor, discoloration, and degradation of the glove. Also, the glove of the present invention is believed to be capable of providing an antimicrobial effect to surfaces contacted by the antimicrobial glove.

Abstract: The present invention discloses compositions derived from an isolated Bacillus species, spores, or an extracellular product of Bacillus coagulans comprising a supernatant or filtrate of a culture of said Bacillus coagulans strain, suitable for topical application to the skin or mucosal membranes of a mammal, which are utilized to inhibit the growth of bacterium, yeast, fungi, virus, and combinations thereof. The present invention also discloses methods of treatment and therapeutic systems for inhibiting the growth of bacterium, yeast, fungi, virus, and combinations thereof, by topical application of therapeutic compositions which are comprised, in part, of isolated Bacillus species, spores, or an extracellular product of Bacillus coagulans comprising a supernatant or filtrate of a culture of said Bacillus coagulans strain.

Abstract: The present invention relates to a novel essentially pH neutral vaginal drug delivery system suitable for modified delivery of a therapeutically active material in the vaginal cavity. The vaginal drug delivery system comprises an essentially pH neutral emulsion having globules having two phases, an internal water soluble phase and an external water-insoluble phase or film, wherein the water-soluble interior phase contains a therapeutically active drug or drugs. One novel aspect of the vaginal drug delivery system is that the internal water soluble phase comprises an acidic buffered phase.

Abstract: A regimen for hunting includes using a number of zeolite-containing personal items in connection with a hunter's apparel and body to reduce the hunter's scent for improved hunting. The personal items include mouthwash, deodorant/anti-perspirant, body and boot powder, bar and liquid soap for cleansing the body and hair, laundry detergent and dryer sheets. Each of the personal items includes an effective amount of zeolite, so that use of the personal items reduces the available scent to be detected by animals in the wild. The regimen can also include the use of a seat cushion that is covered with an activated carbon-containing fabric for odor control and/or elimination.

Abstract: A method of inhibiting production of ammonia from urine held adjacent a user's skin by an article. The method includes applying a composition including a Yucca sp. extract to an area of the wearer's skin. A wipe for wiping surfaces including a flexible sheet and a composition held by the sheet including a Yucca sp. extract.

Abstract: Methods are provided relating to the enhanced cytoplasmic accumulation of amphipathic weakly basic or amphipathic cationic molecules in prokaryotes and eukaryotes under conditions of high extracellular pH. Furthermore, the methods relate to the unexpected synergistic effects of high extracellular pH and disrupted cellular efflux mechanisms on the cytoplasmic accumulation of amphipathic weakly basic or amphipathic cationic molecules in prokaryotes and eukaryotes. Methods are also provided for increasing the therapeutic potency of amphipathic weakly basic or amphipathic cationic compounds, e.g. antiseptics and disinfectants by using the antiseptic or disinfectant in the presence of a multiple drug resistance inhibitor such as reserpine. Finally, methods also relate to the exploitation of the aforementioned discoveries in the screening of small molecules, and libraries thereof, for biological activity in prokaryotes and eukaryotes.

Abstract: Hairy hoof warts in animals are treated by topically administering an effective amount of a composition of aspirin or other compound or derivative of salicylic acid that preferably contains at least 50% by weight and more preferably between about 75% and 100% by weight aspirin or other compound or derivative of salicylic acid. A preferred composition includes aspirin, hydrated lime, sodium bentonite, and chalk or iron oxide.

Abstract: The present invention is directed to a method for increasing the bone mineralization of a human, and more preferably an infant or toddler. The method comprises administering to said human a source of calcium and a fat blend that is low in palmitic acid. The enhanced mineralization results in the production of a higher peak bone mass and correspondingly lowers the incidence of osteoporosis.

Abstract: Antimicrobial and antifogging polymeric films with preferable A/C/E structure useful for the food, medicine and agriculture applications as well as for other general packaging and non-traditional special applications. More preferably, antimicrobial and antifogging films having a A/B/C/E structure. Most preferably, antimicrobial and antifogging films having a A/B/C/D/E structure. A multilayer structure (having at least an skin layer (A) having antifogging and antimicrobial properties/a core layer (C)/an outer layer (E) structure) for semi and biaxially oriented polyolefin based antifogging films having advantageous properties as compared with known and commercial films such as low values of haze, high values of sheen, lower longitudinal and transverse shrinkage, which provides high dimensional stability, and excellent antifogging and antimicrobial properties. Preferably the skin layer (A), having antifogging and antimicrobial properties, is electrical corona or flame treated.

Abstract: Film-forming compositions, as well as methods of making and using, wherein the compositions include an optional active agent, water, a surfactant, and a water-soluble or water-dispersible vinyl polymer comprising amine group-containing side-chains and a copolymerized hydrophobic monomer; wherein the amine equivalent weight of the polymer is at least about 300 grams polymer per equivalent of amine group.

Abstract: At least a part of the antibacterial agent is distributed in the vicinity of the surface of a resin material. The antibacterial agent preferably contains an inorganic antibacterial agent, and more preferably contains metallic components having the antibacterial property. The metallic components available comprise one or more metals selected from the group of consisting of silver, copper, zinc, iron, gold, platinum, palladium, lead, tin, mercury, cadmium, chromium, nickel and cobalt. The inorganic antibacterial agents comprise one or more substances selected from the group consisting of soluble glass, zirconium phosphate, calcium phosphate, zeolite, silica gel, titanium oxide and porous ceramics.

Abstract: A formulation useful in the treatment of drug resistant bacterial infections comprising an effective amount of thymol obtained from the plant Trachyspermum ammi, mint oil containing an appropriate amount of monoterpenes obtained from a hybrid of Mentha spicata and Mentha arvensis, and conventional additives. A method for producing the formulation by mixing the above ingredients and a method for the treatment of drug resistance in a patient by administration of a therapeutically effective amount of the formulation.

Abstract: The invention discloses a composition comprising a sulfur-containing glycine residue combined with urea to increase the permeation of an active agent or drug through human nail tissue. The invention further provides methods of applying the composition to a nail surface.

Abstract: A multi-surface anti-bacterial protective device for preventing transferring of bacteria from one person to another. The multi-surface anti-bacterial protective device includes a multi-layered material capable of being rolled up and also being capable of being severed into multi-layered pieces of material and also being adapted to fastenably cover a surface such as a light switch plate and a door knob; and also includes an anti-bacterial solution being disposed in the multi-layered material.

Abstract: This invention relates to a bath composition based on herbs and a foaming agent, in particular a composition including a reagent consisting of sodium bicarbonate and a weak acid such as citric acid which develops carbon dioxide when it comes into contact with water, combined with a surfactant such as lauryl sulphate, and mixed with a quantity of medicinal herbs. When this composition is immersed in the bathwater, the reagent develops a considerable amount of carbon dioxide which, thanks to the surfactant also present in the composition, gives rise to the formation of foam. At the same time, an infusion is obtained due to the presence of medicinal herbs, with the result that the active constituents of the herbs which are dispersed in the water are readily absorbed by the skin through the pores. The invention also relates to packaging in which a quantity of reagent and medicinal herbs is introduced into a bag made, for example, of non-woven fabric.

Abstract: The present invention is directed to a composition which is used to enhance the elasticity and/or appearance of tissue. Specifically, the present invention is directed to a composition formulated from peptides or peptide-like compounds having low molecular weights and which substantially correspond to sequences found in elastin. The present composition specifically includes chemical modification of the peptides described herein, specifically carboxy and amino modification including the addition of amino acids to either end of the peptide fragments.

Abstract: The invention provides a new formulation of the composition comprising Flos Lonicerae Fructus Forsythiae and Radix Scutellariae. This invention also provides a method for identification with HPLC and the characteristic peaks of the compositions of said composition. The composition possesses antiviral effective, namely, inhibition of influenza virus, parainfluenza virus, herpes I virus and herpes II virus. The invention refers to a method for preparation and control of the active components of Flos Lonicerae Fructus Forsythiae and Radix Scutellariae for its biological activity. The invention also provides a unique raw materials and intermediate formulation.

Abstract: A substrate includes a flexible substantially planar sheet of at least one layer. The layer has a front side and a back side with a donning agent associated with at least one side of the sheet. The donning agent is transferable from the sheet to an object or individual apart from the sheet.

Abstract: The present invention provides, inter alia, durable and renewable biocidal wooden materials for safe food contact items, such as cutting boards and containers, to be used in home kitchens and the food processing industries. The biocidal food contact surfaces of the present invention reduce and eliminate cross-contamination of diseases and make the surfaces or wood cutting boards safer to use. The biocidal materials inactivate any microorganisms that are deposited and prevent the materials from building up biofilms.

Abstract: A fibrous material, which can be an absorbent material, includes a plurality of natural fibers treated with a carboxylic acid-based odor control agent, which are able to withstand insults with an aqueous liquid without dissolving the odor control agent. The acid-based odor control agent is bound to the natural fibers by an organosilicone polymer binder. The binder is water-insoluble, and can form a highly gas permeable coating. The binder is also highly porous, so as to expose the odor control agent to ammonia and other odoriferous gases which it is intended to control.

Abstract: The subject invention concerns novel biopesticides and their use to control cockroaches, carpenter ants, and pharaoh ants. Specifically, highly virulent isolates of Beauveria bassiana in an agricultural composition, can be used to effectively control these pests. Exemplified are Beauveria bassiana No. 447, ATCC 20872, and Beauveria bassiana Sp111, ATCC 74038. Also described are unique formulations which are highly effective for delivering biocontrol agents to target pests. By using these novel compositions, target pests can be controlled without the environmental and public safety hazards presented by chemical control agents.