Implant Or Insert Patents (Class 424/422)
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Patent number: 11185417Abstract: Method and set of surgical instruments for fitting a shoulder prosthesis, and the shoulder prosthesis. The proposed method seeks to interpose a bone graft between the previously prepared glenoid surface (G) of a scapula (S) of a patient's shoulder and the face of a glenoid prosthetic component opposite the articular surface. The set of instruments permit the bone graft to be taken from the upper epiphysis of the humerus (H), either in situ or ex vivo.Type: GrantFiled: August 8, 2019Date of Patent: November 30, 2021Assignee: TORNIER SASInventors: Pascal Boileau, Gilles Walch
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Patent number: 11185616Abstract: Implantable medical product, comprising a basic body and an imidazole derivative in the form of its free base; wherein said basic body has on its polymeric surface a layer containing the imidazole derivative as an active ingredient, which displays an antithrombogenic, antiproliferative, anti-inflammatory or antiadhesive effect, or a combination thereof.Type: GrantFiled: January 31, 2017Date of Patent: November 30, 2021Inventor: Jörg Michael Schierholz
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Patent number: 11160902Abstract: An object of the invention is to provide a cartilage regenerative material that suppresses infiltration of fibrous soft tissue and brings about satisfactory cartilage regeneration, and a method for producing the cartilage regenerative material. Provided is a cartilage regenerative material including a porous body of a biocompatible polymer and a biocompatible polymer film, in which the porous body contains chondrocytes and cartilage matrix, and the cartilage matrix exists in a region of 10% or more of a region extending from the surface of the transplant face of the porous body to a depth of 150 ?m along the thickness.Type: GrantFiled: September 15, 2017Date of Patent: November 2, 2021Assignees: FUJIFILM Corporation, JAPAN TISSUE ENGINEERING CO., LTD.Inventors: Kentaro Nakamura, Hayato Miyoshi, Satoko Hada, Masatoki Watanabe
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Patent number: 11160674Abstract: To provide a stent excellent in deformability, capable of maintaining a radial force for a longer period of time, and having bioabsorbability and a method of producing the same. The bioabsorbable stent has a core structure including a magnesium alloy and a corrosion resistant layer on the core structure, wherein the core structure is formed from a magnesium alloy containing 90 mass % or more of Mg as a main component, Zn, Zr, and Mn as accessory components, and 30 ppm or less of unavoidable impurities selected from the group consisting of Fe, Ni, Co, and Cu, and the alloy excluding aluminum and at least one sort of rare earths selected from the group consisting of Sc, Y, Dy, Sm, Ce, Gd, and La; and the corrosion resistant layer containing magnesium fluoride as a main component with a hydrophilic smooth surface is formed on the core structure with a smooth surface.Type: GrantFiled: July 26, 2019Date of Patent: November 2, 2021Assignees: Japan Medical Device Technology Co., LTD., FUJI LIGHT METAL CO., LTD.Inventors: Makoto Sasaki, Yuki Koga, Yuki Okazawa, Hironori Ueda, Masashi Inoue
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Patent number: 11154509Abstract: A stable, controlled release formulation for oral dosing of vitamin D compounds is disclosed. The formulation is prepared by incorporating one or more vitamin D compounds into a solid or semi-solid mixture of waxy materials. Oral dosage forms can be prepared by melt-blending the components described herein and filling gelatin capsules with the formulation.Type: GrantFiled: October 5, 2017Date of Patent: October 26, 2021Assignees: EIRGEN PHARMA LTD., OPKO RENAL, LLCInventors: Charles W. Bishop, Samir P. Tabash, Sammy A. Agudoawu, Jay A. White, Keith H. Crawford, Eric J. Messner, P. Martin Petkovich
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Patent number: 11116870Abstract: Compositions and blends of biopolymers and copolymers are described, along with their use to prepare biocompatible scaffolds and surgically implantable devices for use in supporting and facilitating the repair of soft tissue injuries.Type: GrantFiled: June 23, 2020Date of Patent: September 14, 2021Assignee: EMBODY INC.Inventors: Michael Francis, Nathan Kemper, Hilary Wriggers
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Patent number: 11116872Abstract: A method of making infused bone fibers employs the following steps: cutting or shaving whole bone into bone fibers, washing the bone fibers, demineralizing or decalcifying at least partially the whole bone or bone fibers and infusing the bone fibers with a supernatant of biologic material or a polyampholyte cryoprotectant or a combination of both to create infused bone fibers. The step of infusing includes exposing the bone fibers to a negative pressure or vacuum to draw the supernatant and/or the polyampholyte cryoprotectant into the bone fibers, or alternatively, exposing the demineralized whole bone to a positive pressure to drive the supernatant and/or the polyampholyte cryoprotectant into the bone. The resultant method creates an infused bone grafting composition having bone fibers taken from whole bone, demineralized or decalcified at least partially and infused with one or more of a supernatant of biologic material or a polyampholyte cryoprotectant or both.Type: GrantFiled: August 17, 2018Date of Patent: September 14, 2021Assignee: Vivex Biologies Group, Inc.Inventors: Timothy Ganey, Tracy Scott Anderson, Harry Thomas Temple
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Patent number: 11103723Abstract: Provided herein are methods for the treatment of bladder dysfunction, including detrusor hyperreflexia and detrusor external sphincter dyssynergia, fecal incontinence, and/or sexual dysfunction in an individual via the use of stably expressed light-responsive opsin proteins capable of selective hyperpolarization or depolarization of the neural cells that innervate the muscles responsible for physiologic functioning of urinary bladder, external urinary sphincter, external anal sphincter, and the male and female genitalia.Type: GrantFiled: October 23, 2015Date of Patent: August 31, 2021Assignees: The Board of Trustees of the Leland Stanford Junior University, Circuit Therapeutics, Inc.Inventors: Karl A. Deisseroth, Elizabeth R. Aden, Viviana Gradinaru, Scott L. Delp
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Patent number: 11096888Abstract: The invention relates to a method for altering the release characteristics of a long acting drug delivery device containing at least two drugs in different segments, wherein the segments are arranged to a specific sequence. The invention furthermore relates to a drug delivery device with reduced initial burst containing two different drugs in different segments. The invention further relates to a delivery device manufactured according to the a.m. method and its use in contraception and gynecological therapies.Type: GrantFiled: May 9, 2016Date of Patent: August 24, 2021Assignee: Bayer OYInventors: Savante Holmberg, Christine Talling
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Patent number: 11097007Abstract: An object of the present invention is to provide a storage-stable injectable preparation comprising a composition comprising a poorly soluble drug as an active ingredient and a dispersion medium. Another object of the present invention is to provide a compact, lightweight prefilled syringe by filling a syringe with the injectable preparation. The present invention provides an injectable preparation comprising a composition comprising a poorly soluble drug, a dispersion medium, and a specific suspending agent, the composition having a viscosity of 40 pascal-seconds or more in at least one point in the shear rate range of 0.01 to 0.02 s?1 and having a viscosity of 0.2 pascal-seconds or less in at least one point in the shear rate range of 900 to 1,000 s?1, as measured.Type: GrantFiled: December 1, 2020Date of Patent: August 24, 2021Assignee: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Daiki Kaneko, Takakuni Matsuda, Yusuke Hoshika
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Patent number: 11090411Abstract: A method of making an electron beam irradiated osteoinductive implant is provided. The method comprises exposing an osteoinductive implant containing demineralized bone matrix (DBM) fibers to electron beam radiation at a dose of from about 10 kilograys to 100 kilograys for a period of time. The electron beam irradiation reduces microorganisms in the osteoinductive implant, and the electron beam irradiated osteoinductive implant retains osteoinductive properties. Methods of implantation and an irradiated osteoinductive implant are also disclosed.Type: GrantFiled: January 28, 2016Date of Patent: August 17, 2021Assignee: Warsaw Orthopedic, Inc.Inventors: Kelly W. Schlachter, Erick Vasquez, Daniel A. Shimko
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Patent number: 11058734Abstract: The invention relates to a probiotic strain selected from Lactobacillus reuteri V340 with accession number CECT and Bifidobacterium breve BT820 with accession number CECT 8606, or a variant of said probiotic strain having cholesterol-absorbing capacity, and to methods and therapeutic uses thereof. The invention also relates to compositions, pharmaceutical compositions, feeds or nutritional products comprising a probiotic strain selected from Lactobacillus reuteri V3401 with accession number CECT 8605 and Bifidobacterium breve BT820 with accession number CECT 8606, or a variant of said probiotic strain having cholesterol-absorbing capacity.Type: GrantFiled: December 10, 2015Date of Patent: July 13, 2021Assignee: BIOSEARCH, S.A.Inventors: Ana Isabel Sañudo Otero, Raquel Criado García, Alba Rodríguez Nogales, Alberto Garach Domech, Mónica Olivares Martín, Julio Juan Gálvez Peralta, Santiago De La Escalera Huerso, Juan Manuel Duarte Pérez, Antonio Zarzuelo Zurita, Óscar Bañuelos Hortigüela
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Patent number: 11051543Abstract: An ingestible compositions includes a first polymer layer, an adhesive layer associated with the first polymer layer, where the adhesive layer includes an adhesive material and is configured to releasably adhere to the first polymer layer, an alginate layer adhered to the adhesive layer, and a second polymer layer associated with the alginate layer and configured to releasably adhere to the alginate layer. Aspects further include methods of making and using the compositions.Type: GrantFiled: July 21, 2016Date of Patent: July 6, 2021Assignee: OTSUKA PHARMACEUTICAL CO. LTD.Inventors: Raymond Schmidt, Hooman Hafezi, Ai Ling Ching, Patricia Johnson, Anuj Patel, Kevin Cheng, Kosuke Iwai
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Patent number: 11027040Abstract: The present disclosure provides a method for manufacturing a porous film, including: preparing a polymer mixture solution, wherein the polymer mixture solution includes polycaprolactone and at least one hydrophobic polymer; adding solid particles as a dispersing agent to the polymer mixture solution and mixing the solid particles with the polymer mixture solution, wherein the amount of solid particles added is enough to convert the polymer mixture solution into a solid mixture; drying the solid mixture to form a film; and washing the film with a washing fluid to remove the solid particles from the film to form the porous film, wherein the weight ratio of the polycaprolactone to the at least one hydrophobic polymer is about 1:0.1-10, and wherein the weight ratio of the polycaprolactone and the at least one hydrophobic polymer to the solid particles is about 1:0.01-250.Type: GrantFiled: December 27, 2017Date of Patent: June 8, 2021Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Hsin-Hsin Shen, Ming-Chia Yang, Chia-Chi Ho, Fang-Jie Jang, Che-Yu Ou, Chi-Hsiang Liao, Brian Hsu, Tai-Horng Young
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Patent number: 11020116Abstract: Various exemplary surgical adjuncts with medicants affected by activator materials are provided. In general, an adjunct is provided with at least one medicant that is configured to be activated by an activator material. The adjunct can be delivered to a tissue of a patient, where the adjunct can be implanted. Various activator materials can be configured to activate the at least one medicant retained by the adjunct, the activation causing any one or more of a variety of actions. For example, the at least one medicant can be activated so as to yield at least one of a signal and/or an effect on the adjunct.Type: GrantFiled: August 31, 2015Date of Patent: June 1, 2021Assignee: Ethicon LLCInventors: Frederick E. Shelton, IV, Jason L. Harris
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Patent number: 11007278Abstract: Embodiments of the present disclosure provide for electroactive supramolecular polymeric assemblies, methods of making electroactive supramolecular polymeric assemblies, methods of using electroactive supramolecular polymeric assemblies, and the like.Type: GrantFiled: April 9, 2020Date of Patent: May 18, 2021Assignee: University of Florida Research Foundation, Inc.Inventors: John Hardy, Christine E. Schmidt
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Patent number: 11000627Abstract: The present invention relates to a process of treating an implant, comprising a step of treating the surface of the implant with at least one phosphonic acid compound or a pharmaceutically acceptable salt, ester or amide thereof under sonication at a temperature of about 50° C. to about 90° C. This process is highly advantageous in that it allows the formation of a monolayer of the phosphonic acid compound on the implant surface, having a particularly dense surface coverage which, in turn, results in an improved implant biocompatibility and improved osseointegration.Type: GrantFiled: February 13, 2017Date of Patent: May 11, 2021Assignee: NANO BRIDGING MOLECULES SAInventors: Sabrina Buchini, Richard Curno, Björn-Owe Aronsson, Péter Péchy
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Patent number: 10993919Abstract: Compositions and methods are disclosed herein to deliver and anchor nanoscale drug carriers into the extracellular matrix (ECM) of tissues, such as degenerating cartilage or tumor margins, and to provide local and sustained release of drugs.Type: GrantFiled: October 3, 2017Date of Patent: May 4, 2021Assignee: University of Florida Research Foundation, Inc.Inventors: Blanka Sharma, Shannon B. Brown
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Patent number: 10961501Abstract: A system for seeding therapeutic active ingredients (TAIs) onto a porous scaffold includes a first chamber for accommodating the scaffold, a TAI storage device for storing TAIs, at least one second chamber for storing TAI media, and a gas inlet for receiving gas from a compressed source. A flow circuit is coupled to the first chamber, the TAI storage device, the second chamber and the gas inlet for delivering the TAIs, the TAI media and the gas to the scaffold. A pump pumps at least one of the TAIs, the TAI media and the gas in the flow circuit. The system also includes a processor that regulates the delivery of the TAIs, the TAI media and the gas to the scaffold via a plurality of valves.Type: GrantFiled: April 9, 2018Date of Patent: March 30, 2021Assignee: EpiBone, Inc.Inventors: Sarindr Bhumiratana, Keith Yeager
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Patent number: 10953135Abstract: Disclosed herein are tissue scaffold materials with microspheres of one density embedded in hydrogel of a different density. The disclosed materials have improved ability to facilitate cellular invasion and vascularization for wound healing and tissue regeneration. The inventors have found that materials having components with different densities promotes invasion of cells, including desirable cells such as fibroblasts and endothelial precursor cells, into the scaffold.Type: GrantFiled: April 12, 2018Date of Patent: March 23, 2021Assignee: Cornell UniversityInventors: Jason Spector, Abraham D. Stroock, John Morgan
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Patent number: 10947282Abstract: Embodiments of the invention are directed to Ubx-fusion molecules that maintain their mechanical strength and properties even after being fused with Ubx. Ubx fusions with VEGF and other growth factors, cell signaling proteins, and cell binding proteins can be used to induce angiogenesis. Ubx fibers and mesh, embedded within a tissue engineering scaffold, induce formation of vasculature within the scaffold. The presence of vasculature is necessary to provide oxygen and nutrients to other cells growing within the scaffold.Type: GrantFiled: January 20, 2016Date of Patent: March 16, 2021Assignees: The Texas A & M University System, William Marsh Rice UniversityInventors: Sarah Bondos, Kayla Bayless, Kathleen Matthews, Jan Patterson, Colette Abbey, David Howell, Hao-Ching Hsiao, Kelly Churion, Shang-Pu Tsai, Sandhya Ramasamy, Dustin Porterpan, Keira Northern
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Patent number: 10945997Abstract: An object of the invention is to obtain a preparation which shows enhanced effectiveness and safety compared to tacrolimus, has the concentration in blood maintained at a constant level without individual differences, whereby the control of the amount of administration depending on the blood kinetics (blood trough concentration) becomes unnecessary. The present invention relates to a polymeric derivative of tacrolimus, in which a polyethylene glycol segment and an alcoholic hydroxy group of tacrolimus are bonded to side-chain carboxy groups of a polyaspartic acid derivative.Type: GrantFiled: December 19, 2016Date of Patent: March 16, 2021Assignee: Nippon Kayaku Kabushiki KaishaInventors: Nao Yoneki, Akihiro Sekiguchi, Kana Mizunuma, Yuki Kobayashi, Junpei Konno, Kan Saiga, Keiichirou Yamamoto
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Patent number: 10940157Abstract: The present disclosure relates to a vaginal system that prevents pregnancy comprised of segesterone acetate and ethinyl estradiol and is configured for thirteen 28-day product-use cycles.Type: GrantFiled: March 10, 2020Date of Patent: March 9, 2021Assignee: The Population Council, Inc.Inventor: Bruce Variano
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Patent number: 10933174Abstract: An anchorage device is provided that is configured to surround an implantable medical device. The anchorage device includes a substrate having a hemostatic agent and an active pharmaceutical ingredient selectively positioned on the substrate. Kits, systems and methods are disclosed.Type: GrantFiled: May 1, 2017Date of Patent: March 2, 2021Assignee: MEDTRONIC, INC.Inventors: Satish Pulapura, Fatima Buevich, Jorie S. Soskin, Franklin R. Mansfield, Kai R. Worrell, Charlie Wood, Jorge Alberto Trevino Blanco
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Patent number: 10932465Abstract: The invention relates to an antimicrobial mixture containing 4-(3-ethoxy-4-hydroxy-phenyl)butan-2-one and an additional compound chosen from chlorhexidine digluconate, chlorhexidine hydrochloride and a polyhexamethylene biguanide salt, and also to a cosmetic composition containing such a mixture. Use in caring for, making up and cleansing keratin materials.Type: GrantFiled: June 27, 2018Date of Patent: March 2, 2021Assignee: L'OREALInventors: Julien Galvan, Sylvie Cupferman, Gael Malet
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Patent number: 10925882Abstract: The present disclosure relates to a vaginal system that prevents pregnancy comprised of segesterone acetate and ethinyl estradiol and is configured for thirteen 28-day product-use cycles.Type: GrantFiled: March 23, 2020Date of Patent: February 23, 2021Assignee: The Population Council, Inc.Inventor: Bruce Variano
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Patent number: 10918649Abstract: The present disclosure relates to a vaginal system that prevents pregnancy comprised of segesterone acetate and ethinyl estradiol and is configured for thirteen 28-day product-use cycles.Type: GrantFiled: June 21, 2019Date of Patent: February 16, 2021Assignee: The Population Council, Inc.Inventor: Bruce Variano
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Patent number: 10881537Abstract: The present invention relates generally a manufacturing process which results in a completely hydrogel polymer device that maintains lumen patency which allows for numerous applications. Catheters and stents are particular examples, and their composition, mechanical characteristics, and the significantly unique ability to conduct and allow fluids to pass from one end to the other without physiological rejection, inflammation, or manifestation of complications due to implant or otherwise undesirable outcomes when used for ambulatory and or therapeutic interventions is the purpose of the invention.Type: GrantFiled: October 13, 2015Date of Patent: January 5, 2021Inventor: Scott M. Epstein
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Patent number: 10881501Abstract: Allografts for soft tissue repair, including breast reconstruction and other plastic surgery procedures, are disclosed. One allograft is made from decellularized dermal tissue and constitutes a collagen matrix having substantially uniform density and porosity. Another allograft is a hybrid bilayer tissue form that is made from decellularized dermal and adipose tissues. Methods for making both allografts are also disclosed.Type: GrantFiled: January 10, 2019Date of Patent: January 5, 2021Assignee: Musculoskeletal Transplant FoundationInventors: Michael Locarno, Bryan Choi, Manh-Dan Ngo
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Patent number: 10881695Abstract: An autologous cell therapy product composed of fibroblasts grown for each individual to be treated for vocal cord scarring. The suspension of autologous fibroblasts, grown from a biopsy of each individual's own buccal mucosa or skin using current good manufacturing practices (CGMP) and standard tissue culture procedures, is supplied in cryovials containing cryopreserved autologous fibroblasts or precursors thereof, at a concentration of between 1.0×107 cells/mL and 2.7×107 cells/mL, wherein at least 85% of the human fibroblast cells are viable after freezing and thawing.Type: GrantFiled: September 7, 2018Date of Patent: January 5, 2021Assignee: Fibrocell Technologies, Inc.Inventor: John Maslowski
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Patent number: 10881619Abstract: In one aspect, the present disclosure provides microparticles that are configured to release a first drug over a first time period and to release a second drug over a second time period, wherein a lag period of substantially no drug release occurs between the first and second time periods. In other aspects, the present disclosure pertains to the use of such microparticles in delivery systems and methods of treatment. In another aspect, the present disclosure pertains to drug delivery systems that comprising a folded inflatable drug delivery balloon that comprises folds and microparticles positioned within the folds.Type: GrantFiled: December 28, 2015Date of Patent: January 5, 2021Assignee: Boston Scientific Scimed, Inc.Inventors: Javier Palomar-Moreno, Michelle Hannon, Phillip Bannister
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Patent number: 10881622Abstract: Technologies are described for delivery of compounds to aid in weight management. A transdermal microdispenser based system may deliver weight management compounds through the time and dose specific administration of appetite suppression, metabolic enhancers, and satiation compounds. The transdermal delivery system may be controlled based on data associated with subject such as calorie intake, physical activity, satiation, and hunger. The system may be integrated with medical monitoring or fitness tracking systems. Delivery of the compounds may be distributed over the course of a day at selected or adjusted doses to be safe and effective for their specific modality. For example, appetite suppressants may be delivered during periods of the day when cravings occur, satiation compounds may be delivered to coincide with meals, and metabolic stimulators may be delivered at times to optimally increase metabolism based on caloric balance. Control factors may also be predictive to prevent the onset of hunger.Type: GrantFiled: September 17, 2018Date of Patent: January 5, 2021Assignee: Xinova, LLCInventors: Michael Keoni Manion, Stephanie Brunelle
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Patent number: 10874108Abstract: A metal-EDTA compound/complex for combatting biofilms and/or treating wounds. The compound/complex comprises EDTA and from two to four metal ions. Of those two to four metal ions, at least two are different metal ions selected from Ag, Al, Au, Ba, Bi, Tl, Ce, Co, Cu, Fe, Ga, Ir, Mo, Rh, Ru, Ti, and Zn ions. The metal-EDTA compound/complex may exhibit any one or more of anti-microbial, anti-biofilm and anti-inflammatory activities in use and may increase the susceptibility of a biofilm and the microorganisms within said biofilm to attack by anti-microbial agents, helping to remove and sanitise the biofilm. A composition, wound dressing and medical device comprising the metal-EDTA complex are also provided. Uses of the metal-EDTA compound/complex as a medicament and/or to sanitise and/or substantially remove a biofilm from a substrate are also disclosed.Type: GrantFiled: May 4, 2017Date of Patent: December 29, 2020Assignee: 5D Health Protection Group Ltd.Inventors: Steven Percival, Rui Chen, John Alan Hunt
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Patent number: 10869948Abstract: Disclosed is a composition of a collagen peptide and an elastin peptide, method of producing the same and use thereof. The composition of the present disclosure consists of a collagen peptide and an elastin peptide; the collagen peptide is prepared by enzymatic hydrolysis of a collagen material with pepsin or trypsin, and the elastin peptide is prepared by enzymatic hydrolysis of an elastin material with papain and/or protease Protamex. In the present disclosure, an elastin peptide and a collagen peptide with molecular weight in a specific range are prepared by specific processes, and the composition composed of the two at a suitable ratio can simultaneously and significantly increase the amount of the elastin and collagen in a damaged skin in a small usage amount, and significantly increase the content of hyaluronic acid and hydroxyproline while decrease the content of MMP3, meanwhile, inhibit skin inflammatory factors.Type: GrantFiled: May 16, 2019Date of Patent: December 22, 2020Assignee: INFINITUS (CHINA) COMPANY LTD.Inventors: Huawei Zhu, Xiaoling Wang, Liugang Ding, Xiaolei Guo, Yazhong Ge
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Patent number: 10869947Abstract: Hydrogel compositions are provided (a) that have a continuous hydrophobic phase and a discontinuous hydrophilic phase, (b) that have a discontinuous hydrophilic phase and a continuous hydrophilic phase, or (c) that are entirely composed of a continuous hydrophilic phase. The hydrophobic phase, if present, is composed of a hydrophobic polymer, particularly a hydrophobic pressure-sensitive adhesive (PSA), a plasticizing elastomer, a tackifying resin, and an optional antioxidant. The discontinuous hydrophilic phase, if present, is composed of a crosslinked hydrophilic polymer, particularly a crosslinked cellulosic polymer such as crosslinked sodium carboxymethylcellulose. For those hydrogel compositions containing a continuous hydrophilic phase, the components of the phase include a cellulose ester composition or an acrylate polymer or copolymer, and a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding thereto.Type: GrantFiled: April 29, 2014Date of Patent: December 22, 2020Assignees: Corium, Inc., A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of SciencesInventors: Gary W. Cleary, Shoreh Parandoosh, Mikhail M. Feldstein, Anatoly E. Chalykh, Nicolai A. Platè, Valery G. Kulichikhin
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Patent number: 10864304Abstract: A material including a plurality of fatty acid chains cross-linked together and a silver fatty acid salt formed with the fatty acid chains within the material. Methods for forming a material are also included. The silver-containing materials can be utilized alone or in combination with a medical device for the release and local delivery of one or more anti-infective agents.Type: GrantFiled: May 19, 2014Date of Patent: December 15, 2020Assignee: ATRIUM MEDICAL CORPORATIONInventors: Keith M. Faucher, Hilda N. Rono, Anthony Richard Horton, Jocelyn Choroszy, Paul Martakos
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Patent number: 10842913Abstract: Tissue repair and restoration can be performed using an elastic material formed from tropoelastin. The elastic material can be formed by providing a solution of tropoelastin monomers, applying the solution to a surface, and heating the solution on the surface in absence of a cross-linking agent to enable the tropoelastin monomers to bind to each other to form an elastic material that does not dissociate into tropoelastin monomers when the elastic material is contacted with an aqueous solution.Type: GrantFiled: December 10, 2013Date of Patent: November 24, 2020Assignee: ALLERGAN PHARMACEUTICALS INTERNATIONAL LIMITEDInventors: Anthony Steven Weiss, Suzanne Marie Mithieux
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Patent number: 10847363Abstract: Methods are provided for selective film deposition. One method includes providing a substrate containing a dielectric material and a metal layer, the metal layer having an oxidized metal layer thereon, coating the substrate with a metal-containing catalyst layer, treating the substrate with an alcohol solution that removes the oxidized metal layer from the metal layer along with the metal-containing catalyst layer on the oxidized metal layer, and exposing the substrate to a process gas containing a silanol gas for a time period that selectively deposits a SiO2 film on the metal-containing catalyst layer on the dielectric material.Type: GrantFiled: November 16, 2018Date of Patent: November 24, 2020Assignee: Tokyo Electron LimitedInventor: Kandabara Tapily
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Patent number: 10821182Abstract: Disclosed herein are compositions comprising an NSAID such as meloxicam and/or rizatriptan in combination with a cyclodextrin and/or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan may be administered in a manner that results in a Tmax of meloxicam of 3 hours or less.Type: GrantFiled: May 6, 2020Date of Patent: November 3, 2020Assignee: AXSOME THERAPEUTICS, INC.Inventor: Herriot Tabuteau
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Patent number: 10813763Abstract: An implantable mesh including demineralized bone fibers mechanically entangled into a biodegradable or permanent implantable mesh is provided. A method of preparing the implantable mesh is also provided. The method of preparing the implantable mesh includes mechanically entangling demineralized bone fibers with non-bone fibers to form the implantable mesh. The mechanical entanglement of the bone fibers into the implantable mesh is achieved by applying needle punching with barbed needles, spun lacing, entanglement with water jets or air jets or ultrasonic entanglement with ultrasonic waves. A method of implanting an implantable mesh at a target bone tissue site is also provided.Type: GrantFiled: July 26, 2016Date of Patent: October 27, 2020Assignee: Warsaw Orthopedic, Inc.Inventor: Kelly W. Schlachter
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Patent number: 10800708Abstract: The object of the present invention is to provide an antibacterial material capable of sustaining antibacterial properties for a long time. The object can be solved by a silver-containing calcium phosphate sintered body having silver particles therein, wherein an average particle diameter of the silver particles is 0.01 to 0.5 ?m.Type: GrantFiled: February 28, 2017Date of Patent: October 13, 2020Assignees: TOKYO INSTITUTE OF TECHNOLOGY, KYOCERA CORPORATIONInventors: Toshiyuki Ikoma, Tomoaki Sugiyama, Hiroaki Igashira, Yugo Fukuyama, Michimasa Kamo, Masayuki Kyomoto, Takashi Sasaki
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Patent number: 10799611Abstract: The present invention relates to a dry composition, which upon addition of an aqueous medium forms a substantially homogenous paste suitable for use in haemostasis procedures. The paste forms spontaneously upon addition of the liquid, hence no mechanical mixing is required for said paste to form. The invention further relates to methods of preparing said dry composition, a paste made from said dry composition and use of said paste for medical and surgical purposes.Type: GrantFiled: April 26, 2018Date of Patent: October 13, 2020Assignee: Ferrosan Medical Devices A/SInventor: Kristian Larsen
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Patent number: 10792029Abstract: A bone suture assembly including a flexible generally cylindrical sleeve, a plurality of lengths of suture extending through the generally cylindrical sleeve, and at least one sleeve securing thread associated with the generally cylindrical sleeve. A bone suture retaining method including engaging a suture with a bone engaging sleeve, inserting the suture and the bone engaging sleeve engaged thereby into a transosseous tunnel formed into a bone by pulling the bone engaging sleeve into the transosseous tunnel and retaining the suture and the bone engaging sleeve in the transosseous tunnel by virtue of the bone engaging sleeve being unable to fit through an aperture in the bone.Type: GrantFiled: September 9, 2015Date of Patent: October 6, 2020Assignee: MININVASIVE LTD.Inventors: Boaz Harari, Mordehai Sholev, Ronen Raz, Arnon Mousaiuf, Dror Rosner, Paul Mraz
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Patent number: 10787485Abstract: The invention relates to a peptide comprising (i) a main chain comprising at least one L-3,4-dihydroxyphenylalanine (DOPA), (ii) at least one integrin binding peptide, and (iii) at least one heparin binding peptide. The invention further relates to a coating for metal surfaces comprising the peptide according to the invention and a coated metal surface which promotes osseointegration that can be obtained by reacting the peptide according to the invention with a metal surface.Type: GrantFiled: September 16, 2016Date of Patent: September 29, 2020Assignee: UniversitätInventors: Annette Beck-Sickinger, Mareen Pagel, Rayk Hassert
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Patent number: 10772716Abstract: A method for promoting healing of tissue by delivering a bioreactor into a subject is provided. The bioreactor is an enclosed housing with paracrine factor producing cells enclosed within the housing. The housing is impermeable to the paracrine factor producing cells, impermeable to immunological cells outside of the housing, and permeable to paracrine factors produced by the paracrine factor producing cells. The paracrine factors produced by the paracrine factor producing cells are released out of the housing to promote healing of the tissue.Type: GrantFiled: February 21, 2019Date of Patent: September 15, 2020Assignee: The Johns Hopkins UniversityInventors: Gary Gerstenblith, Jason Benkoski, George Coles, Chao-Wei Hwang, Peter Johnston, Gordon Tomaselli, Robert G. Weiss, Steven P. Schulman, Jeffrey A. Brinker
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Patent number: 10773062Abstract: Methods and devices to affect types, proportion, quantity, distribution, or proliferation of microorganisms within a female reproductive system.Type: GrantFiled: September 18, 2017Date of Patent: September 15, 2020Assignee: Nine Medical, Inc.Inventors: Benjamin Kahn Cline, Ryan Kendall Pierce
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Patent number: 10758643Abstract: A medical product which contains a mechanophore, and the use of a mechanophore for producing a medical product.Type: GrantFiled: August 3, 2016Date of Patent: September 1, 2020Assignee: Aesculap AGInventors: Kris Brosig, Michael Utz
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Patent number: 10751417Abstract: Described herein are drug delivery systems for delivering biologically active agents comprising primary or secondary amines, or a ring nitrogen atom of an azaheteroaryl ring, pharmaceutically acceptable salts thereof, drug delivery reagents related thereto, pharmaceutical compositions comprising the drug delivery systems, and the use of the drug delivery systems as sustained release therapeutics.Type: GrantFiled: April 19, 2018Date of Patent: August 25, 2020Assignee: Novartis AGInventors: Christopher M. Adams, Myriam April, Tanzina Fazal, Cornelia Jutta Forster, Edward Charles Hall, Cameron Chuck-munn Lee
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Patent number: 10744110Abstract: The present invention provides methods and compositions for treating non-small-cell lung cancer (NSCLC) by administering a) a composition comprising nanoparticles that comprise paclitaxel and an albumin and b) a platinum-based agent (e.g., carboplatin), wherein the individual has diabetes, has four or more metastatic sites, and/or is at least about 70 years old.Type: GrantFiled: March 10, 2014Date of Patent: August 18, 2020Assignee: Abraxis BioScience, LLCInventor: Neil P. Desai
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Patent number: 10744233Abstract: Inventive concepts relate generally to the field of implantable urological devices, and more particularly to compositions that inhibit crystallization of urine components. Described are implantable urological devices including a surface and a crystallization inhibitor composition, the crystallization inhibitor composition including: (a) an inhibitor of urine component crystallization in combination with a biodegradable polymer, or a polyalkene homopolymer or copolymer, or (b) a biodegradable polymer that includes an inhibitor of urine component crystallization, wherein the crystallization inhibitor composition provides controlled release of the inhibitor of urine component crystallization from the surface of the device into a subject. Methods of making the implantable urological devices are also described.Type: GrantFiled: February 24, 2017Date of Patent: August 18, 2020Assignee: Innovative Surface Technologies, Inc.Inventor: Kristin Taton