Abstract: A medicated animal feed additive in a solid particulate or granular form having improved resistance to powdering and good fracture toughness is provided. The animal feed additive according to the present invention does require a compression or compacting step to achieve its solid structural form. The present invention also provides a method of producing animal feed compositions. In a further embodiment, the present invention relates to a method of combating microbial infection in animals comprising orally administering to said animals a prophylactic or therapeutic amount of an animal comestible composition comprising a medicated feed supplement according to the present invention.

Abstract: Liquid lysine can be made with almost any particular specification that may be reasonably expected. A multistep process for producing lysine includes at least: fermentation, ultrafiltration, evaporation, and mixing. Depending upon the particular specifications that are to be met, at least two liquids may be taken from selected points in the multistep process. The lysine in these two liquids is concentrated to a desired level and then the liquids are mixed together and returned to the processing feed stream. The process may be applied to any amino acid which can be produced by fermentation.

Abstract: A process is provided for enhancing reproductive performance in a companion animal such as a dog or cat by feeding the animal a diet including omega-6 and omega-3 fatty acids in a ratio of from about 3.5:1 to about 12.5:1. When an animal is fed the diet of the present invention, the essential fatty acid status in the animal is maintained, and litter size is maintained through subsequent parities.

Abstract: The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local reactions to the vaccine in the injected animal.

Abstract: The present invention provides a multi-compartment package, a machine for the automated or semi-automated packaging of a diverse array of animal supplements into such packaging, and a process allowing efficient procurement and fulfillment of custom supplement orders.

Abstract: The present invention relates to the treatment of gastrointestinal disease and/or cancer, and a method of weight gain, via the ingestion of polymeric compositions in humans, animals or birds in need of said treatment. The invention provides methods for the treatment of cancer, the treatment and/or prevention of gastrointestinal disease and/or infection and/or diarrhea and a method for increasing weight gain in humans, animals or birds comprising administering to said humans, animals or birds an effective amount of a pharmaceutical or veterinary composition or feed additive, comprising an effective amount of a polymer and/or copolymer, having the repeating polymeric unit (I) wherein R is H or alkyl, usually C1 to C4, or this unit in hydrated, hemiacetal or acetal form, together with a pharmaceutically or veterinarally acceptable carrier, diluent, adjuvant, excipient and/or controlled release system.

Abstract: A mineral supplement or feed for ruminant animals, especially deer, contains effective amounts of sulfur and garlic to repel insects from the animals. By inducing the repellant into the animal via ingestion of the mineral supplement or feed, disease and stress in the animals as caused by the insects is reduced.

Abstract: Prolonged parenteral release into the circulatory system of a cow of a bioactive bovine somatotropin at desirably effective levels can be achieved using novel compositions in which the bovine somatotropin is present in an aqueous liquid at a dose of at least about 150 mg and at a concentration of at least about 50 mg/ml. The aqueous bovine somatotropin formulation provides for the sustained release of bovine somatotropin into the circulatory system of the animal for greater than three (3) days.

Abstract: The present invention relates to a composition for use in animal nutrition comprising a controlled release matrix and to a method for preparing said composition. Moreover, the present invention relates to a method for the treatment of monogastric animals in which said composition is used as addition of active substances such as for instance organic acids and/or inorganic acids for preserving and acidifying food for monogastric animals, including swine, sheep, rabbits, birds, horses, pets and humans.

Abstract: Disclosed are a multipurpose, high-functional, alkaline solution composition, preparation therefor and use thereof as a nonspecific immunostimulator. The composition comprises 1-25 parts by weight of borax (Na2B4O7.10H2O), 10−5-10−4 parts by weight of sodium thiosulfate (Na2S2O3.5H2O), 30-150 parts by weight of potassium carbonate, 30-200 parts by weight of refined sugar (C12H22O11), and 100-200 parts by weight of water, based on 100 parts by weight of sodium metasilicate (Na2SiO3.5H2O). In addition to bringing about an improvement in disease resistance, weight gain rate, crop yield, crop quality, harvest time, the composition shows nonspecific immunostimulating activities, including antibody production and immune enhancement, by activating immune cells, thereby maximizing vaccination effects on malignant viral diseases.

Abstract: The present invention provides compositions of matter which allow for the extended release and enhanced bioavailability of biologically-active polypeptides following parenteral delivery to an animal. More particularly, it concerns compositions comprising biologically-active somatotropin formulated for extended release, methods of preparing these compositions, and methods of using the same. These compositions comprise somatotropin, a pH-adjusting constituent (PAC), and a substantially non-aqueous, hydrophobic excipient. The PAC may comprise any suitable, biocompatible compound including, but not limited to one or mixtures of two or more of the following: acetic acid, phosphoric acid, monobasic phosphate. The PAC is added to the compositions of matter in an amount effective to adjust the pH to or near to the isoelectric point (pI) of the somatotropin component.

Abstract: The present invention relates to a method for the production of natural taurine-enriched milk using biological metabolism, in which a precursor for synthesis of taurine is prepared in the shape of a pallet or matrix resistant to degradation in the rumen of ruminants and added to a feedstuff, such that biosynthesis of taurine is induced by stimulation of a substrate. According to the method of the present invention, methionine or methionine precursor which is the precursor for taurine synthesis is coated with additives including an inert material and a filler, and thus protected from a rumen pH and an enzymatic action of rumen microorganisms. As a result, problems of the rumen degradation and the metabolism obstruction can be solved. Taurine-enriched milk according to the present invention contains taurine at a higher concentration than general milk, and hence, can be effectively used for the preparation of functional baby foods, and for the preparation of health foods.

Abstract: Enzyme feed supplements containing fungal cellulase produced by Trichoderma viride are specially adapted for increasing protein digestability of dairy cow and cattle feed. Preferred embodiments of the present invention include enzyme formulations adapted for application to corn and enzyme formulations adapted for application to grain sorghum, to which is added Trichoderma viride cellulase. An increase in protein digestability has been evidenced by increased protein content of milk and increased nitrogen retention from the feed.

Abstract: A process is provided for reducing adiposity in an animal such as a companion animal by feeding the animal an effective amount of Vitamin A for a time sufficient to reduce adiposity in the animal. Preferably, the such effective amount comprises from about 50,000 IU to about 1,000,000 IU of Vitamin A per kilogram of diet. Such an effective amount provides sufficient Vitamin A to decrease accumulation of body fat, increase UCP1 levels, and decrease serum leptin levels in the animal.

Abstract: The invention concerns a rehydration fluid composition, useful in particular for feeding young animals no longer able to digest milk, comprising lactose or glucose or a product based on lactose or glucose: a mineral supplement ensuring restoration of digestive losses. The invention is characterised in that the composition further comprises an efficient quantity of soluble vegetable proteins and vegetable lipids ensuring suitable appropriate energy intake.

Abstract: A method and composition for destruction of infectious prion proteins in tissue, by thermal/enzymatic treatment of the tissue with a prion-destructive protease. The method and composition are applicable to treatment of tissue containing or contaminated with prion protein strains associated with transmissible spongiform encephalopathy (TSE) and/or other prion protein-mediated diseases.

Abstract: Disclosed is calcium metasilicate having an aspect ratio (average major axial diameter/average minor axial diameter) of from about 1:1 to about 2.5:1, and an oil absorption of from about 20 ml/100 g to about 220 ml/100.

Abstract: The present invention includes a method for increasing meat production while reducing fat in ruminant and non-ruminant animals and for increasing egg production in poultry and milk production in ruminant animals. The method includes mixing ingredients that include 190 proof ethanol in a concentration of about 9% by weight of a food supplement with clay and a nitrogen source such as urea to form the food supplement. The food supplement for ruminant animals additionally includes a condensed distiller's soluble fraction. The mixed ingredients are added to an animal feed such as corn. The animal feed and supplement are fed to an animal at least one per day.

Abstract: A fluid delivery device comprising a chamber or electrode, wherein the chamber or electrode is capable of containing a chemical and/or electrochemical reagent which expands upon a chemical reaction of the same. The expansion, in turn, displaces a displaceable member which facilitates delivery of fluid from an associated reservoir.

Abstract: The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local reactions to the vaccine in the injected animal.

Abstract: A method of preparing a ruminant feed material with decreased nitrogen solubility, comprising mixing a liquid feed product containing a salt with a protein feedstuff. The protein feedstuff contains crude protein in an amount from 30% to 70% by weight. The liquid feed product containing a salt and the protein feedstuff are mixed under conditions sufficient to decrease the nitrogen solubility of the protein source. Also provided is a ruminant feed material with decreased nitrogen solubility.

Abstract: A digestive system bezoar in a human or non-human animal susceptible to bezoar formation can be reduced in size by administering to the animal a food grade agent for emulsifying fat in an amount sufficient to reduce the size of the bezoar so that the bezoar can pass out of the animal's digestive system. In a similar method for preventing bezoar formation in a human or non-human animal susceptible to bezoar formation, a food grade agent for emulsifying fat can be administered to the animal in an amount sufficient to prevent formation of bezoars, or at least to prevent formation of bezoars larger than a size that becomes trapped in the animal's digestive system.

Abstract: A method is provided for treating bovine mastitis by applying a porous strippable polymer film containing a medicament to the udders of the bovine.

Abstract: An aqueous gel suitable for ingestion by a cat or dog comprising, a. an effective amount of a gelling agent, b. an effective amount of a cat or dog palatability enhancing agent, and c. at least about 85 wt. % water.

Abstract: The invention is a dietary supplement for animals, especially dogs, for treating arthritis and joint discomfort. A biscuit form of the supplement may be in the form of a conventional carrier composition of, for example, typical dog biscuit materials including cereal grains, vegetables or animal meat, fat and by-products. Typically, the biscuit contains about 89-97 weight percent (wt. %) of the conventional carrier composition. Optional vitamins and minerals may also be added to the carrier material, typically in about the 1-5 wt. % range. Importantly, the biscuit of the present invention contains about 3-7 wt. % of an arthritis-treating combination, namely, glucosamine sulfate, vitamin C and an array of intracellular ions namely potassium, sodium and iodine. The glucosamine component is present by weight at approximately the same level as the vitamin C, and at approximately 10 (ten) times the level of the sum of the above-named intracellular ions.

Abstract: This invention provides a feedstock for controlling hypocalcemia in prepartum dairy cattle. An essential feature of the feedstock is a dietary cation-anion difference (DCAD) with a value between about −5 and +20 meq/100 g dietary DM. Other essential features are a weight ratio of potassium:magnesium between about 3-5:1, and between about 1-12 g/kg dietary DM of omega-6 fatty acid derivative having rumen-bypass properties.

Abstract: An antiinfective-free formulation for prophylactic traetment of mastitis in dry cows comprises a seal formulation having approximately 65% by weight of bismuth sub-nitrate in a gel based on aluminum stearate. The seal formulation is prepared by adding the bismuth sub-nitrate to the gel base in at least two separate stages.

Abstract: This invention relates, generally, to nutritional supplements which contain bioactive glass. These supplements are useful in both veterinary and human contexts. The compositions of the subject invention can be used to achieve a number of advantageous results including: enhancing the growth rates of young animals, osteogenic stimulation, strengthening the skeletal structure, and treating osteoporosis.

Abstract: The invention provides a method and compositions for controlling food borne enteric bacterial pathogens in animals. Populations of enteropathogenic bacteria may be substantially reduced or eliminated by treatment of animals with an effective amount of the compound Xm(ClO3)n, wherein X is a cationic moiety and m and n are independently selected from integers necessary to provide a net valency of 0. The compounds may be administered orally, providing a reduction in the populations of the enteropathogenic bacteria in the alimentary tract of the animal, or they may be applied externally onto the animal to reduce the populations of any such bacteria which may be present as contaminants on the surface of the animal. The method and compositions are particularly useful for the control of Salmonella species, enteropathogenic Escherichia coli, and Clostridia species.

Abstract: Prolonged parenteral release into the circulatory system of a cow of a bioactive bovine somatotropin at desirably effective levels can be achieved using novel compositions in which the bovine somatotropin is present it an aqueous liquid at a dose of at least about 150 mg and at a concentration of at least about 50 mg/ml. The aqueous bovine somatotropin formulation provides for the sustained release of bovine somatotropin into the circulatory system of the animal for greater than three (3) days.

Abstract: The direct pour-on skin solution intended to eliminate parasites, in particular Boophilus microplus, from cattle and sheep comprises from 0.05 to 25%, preferably from 0.05 to 10%, and in particular from 0.

Abstract: Seaweed supplement, e.g., seaweed extract or seaweed meal is directly fed to cattle or pigs in amount of 0.01 to 5% by weight of diet to enhance carcass quality. The enhancement of carcass quality for cattle is manifested by increased quality grade, increased marbling, increased ribeye area and decrease in yield grade in meat obtained on slaughter compared to where seaweed supplement is not fed. The enhancement of carcass quality for swine is manifested by increased marbling, increased firmness and decreased cooler shrink in meat obtained on slaughter compared to where seaweed supplement is not fed.

Abstract: A dry composition of an ionophore antibiotic such as monensin comprising from 10 to 95% (when expressed as the sodium salt) of at least one crystalline ionophore antibiotic, from 0 to 10% antifoam agent(s), from 0.1 to 20% wetting and/or surfactant agent(s), from 0.1 to 10% dispersal agent(s), and from 0.1 to 20% suspension agent(s). The use of the composition is as a suspension in water alone or in conjunction with a milk replacer composition and/or a milk extender composition in water as a calf feed composition.

Abstract: A ruminant direct fed microbial composition of matter comprising an acidosis inhibiting effective amount of Propionibacterum P-63 is provided. Also disclosed is a process for reducing acidosis in ruminants or scours in swine by administration of the bacterium to the ruminant or swine. The microbial composition may be administered by itself, or combined with animal feed and/or lactic acid producing cultures.

Abstract: Modafinil is effective in improving symptoms of eating disorders or in stimulating appetite.

Abstract: The present invention relates to a composition for the delivery of active agents that are protected from environmental oxidation and are resistant to ruminal fermentation degradation but not intestinal digestion and adsorption. The composition may contain biologically active ingredients such as for example, vitamins, minerals, proteins, amino acids, fatty acids, nutritional supplements, and pharmaceuticals together with natural and/or synthetic lecithin phospholipids.

Abstract: Disclosed are a multipurpose, high-functional, alkaline solution composition, preparation therefor and use thereof as a nonspecific immunostimulator. The composition comprises 1-25 parts by weight of borax (Na2B4O7.10H2O), 10−5-10−4 parts by weight of sodium thiosulfate (Na2S2O3.5H2O), 30-150 parts by weight of potassium carbonate, 30-200 parts by weight of refined sugar (C12H22O11), and 100-200 parts by weight of water, based on 100 parts by weight of sodium metasilicate (Na2SiO3.5H2O). In addition to bringing about an improvement in disease resistance, weight gain rate, crop yield, crop quality, harvest time, the composition shows nonspecific immunostimulating activities, including antibody production and immune enhancement, by activating immune cells, thereby maximizing vaccination effects on malignant viral diseases.

Abstract: The present invention provides a mammalian teat dip composition capable of being used during a mammal's dry period comprising a solution of a film-forming polymer blend comprising a first polymer component which is an organic, solvent-soluble, preformed, thermoplastic polyurethane having no reactive isocyanate groups and a second polymer component which is a hydrophilic poly(N-vinyl lactam), said blend capable of withstanding exposure to water without significant loss of said hydrophilic poly(N-vinyl lactam) in an amount sufficient to form a water-resistant film upon topical application to mammalian skin; and wherein said blend comprises from about 10 to about 80 weight percent of said first polymer in combination with said solvent and from about 1 to about 20 weight percent of said second polymer; and at least one antimicrobial agent in an amount sufficient to treat and protect mammalian skin from infection; wherein said composition is capable of being removed by peeling.

Abstract: The present invention concerns a method of enhancing milk production by a ruminant that includes providing a feed that contains sorbitol and at least one additional feed component, and orally feeding the feed to the ruminant, the ruminant ingesting about 100 grams, or less, of sorbitol per day.

Abstract: The present invention relates to orally administrable pastes of toltrazuril sulfone, comprising active compound in a concentration of 0.1-20% by weight, with a particle size of from 1 to 10·10−6 m, polyacrylic acids having a degree of polymerization of about 3·106 in a concentration of 0.1-5% by weight and, if appropriate, preservatives and moisturizers, and the remainder to 100% by weight water.

Abstract: The invention concerns a device for dispensing an active substance to be used in a biological medium, in particular in the rumen of an animal, comprising: a sealed receptacle (1, 21, 41, 71, 81, 100, 120, 130) for containing the said substance, and having at least one opening; means for provisionally closing the opening of said receptacle, said closing means being maintained closed by at least one biodegradable element (13, 23, 45, 55, 65, 78, 89, 109, 113, 125, 135), such that subsequent to the biological degradation of said element, the closing means completely releases said opening.

Abstract: A method for the preparation of a handleable, flowable coated cottonseed product is provided which involves coating cottonseed with a composition of (a) water or a liquid feed product, (b) a soluble phosphorous source and (c) a metal compound capable of interacting with the soluble phosphorous source to form a coating on the cottonseed, and curing the coating formed thereby, and the flowable cottonseed product formed thereby, as well as its use as a feed supplement for ruminants such as cattle, as a plantable source of cottonseed, and in a method for treatment and/or prevention of urinary calculi or prevention of milk fever in cattle.

Abstract: A bolus for oral administration of selenium to ruminants comprising 2% to 25% by weight of the trace mineral selenium in its elemental state and in particulate form, 70% to 97.5% by weight of an inert powdered weighting agent and, optionally, 0.25 to 5% by weight of an inert lubricant is provided.

Abstract: A device for dispensing an active substance to be used in a biological medium, in particular in the rumen of an animal, includes a sealed receptacle for containing the substance, and having at least one opening; a closure for provisionally closing the opening of the receptacle, the closure being maintained closed by at least one biodegradable element such that subsequent to the biological degradation of the element, the closure completely releases the opening.

Abstract: The direct pour-on skin solution intended to eliminate parasites, in particular Boophilus microplus, from cattle and sheep comprises from 0.05 to 25%, preferably from 0.05 to 10%, and in particular from 0.1 to 2% weight/volume, relative to the total solution, of a compound of formula (I): in a formulation at low volume, designed to release the compound (I) onto the skin and the hairs for a contact action against parasites.

Abstract: The direct pour-on skin solution intended to eliminate parasites, in particular Boophilus microplus, from cattle and sheep comprises from 0.05 to 25%, preferably from 0.05 to 10%, and in particular from 0.

Abstract: A veterinary delivery system in the form of a pliable film comprising at least one binder, at least one lubricant, at least one solvent for the binder and lubricant, and an effective amount of at least one effective agent. According to one embodiment, a flavorant is included in a pliable hydrophilic film in order to enhance oral acceptability by the animal. In other embodiments, the films preferably have a moisture content of about 2-15%, preferably about 3-7% by weight. The hydrophilic films most preferably have at least one effective agent distributed homogeneously throughout the film.

Abstract: The invention discloses a mammalian teat dip for controlling mastitis, a method for preparing the composition and a method of treatment of mammals. The composition contains a film-forming polymer blend, at least one antimicrobial and a sodium bicarbonate buffering agent. The polymer blend contains a solvent-soluble, thermoplastic polyurethane and a hydrophilic poly(N-vinyl lactam). Upon application to mammalian skin, this composition leaves a long-lasting, water-resistant, residual, elastic film that treats and protects mammalian skin from infection.

Abstract: Seaweed supplement, e.g., seaweed extract or seaweed meal is directly fed to cattle or pigs in amount of 0.01 to 5% by weight of diet to enhance carcass quality. The enhancement of carcass quality for cattle is manifested by increased quality grade, increased marbling, increased ribeye area and decrease in yield grade in meat obtained on slaughter compared to where seaweed supplement is not fed. The enhancement of carcass quality for swine is manifested by increased marbling, increased firmness and decreased cooler shrink in meat obtained on slaughter compared to where seaweed supplement is not fed.

Abstract: A process for formulating a ruminant food ration in which the methionine needs of the ruminant are determined, a plurality of natural or synthetic feed ingredients and the nutrient composition of each of said ingredients are identified wherein one of said ingredients is 2-hydroxy-4-(methylthio)butanoic acid or a salt, amide or ester thereof, and a ration is formulated from the identified feed ingredients to meet the determined methionine needs of the ruminant which comprises one or more grains, a hydroxy analog of methionine, and optionally a bypass fat wherein (i) the hydroxy analog of methionine is selected from the group consisting of 2-hydroxy-4-(methylthio)butanoic acid and the salts, amides and esters thereof, (ii) the hydroxy analog of methionine is added separately from any bypass fat which is included in the ration, and (iii) the ration is formulated on the basis that at least 20% of the hydroxy analog of methionine is assumed to be available for absorption by the ruminant.