Resorbable By The Body Patents (Class 424/444)
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Patent number: 8679523Abstract: The present invention comprises methods and compositions for delivery devices. More particularly, the present invention comprises methods and compositions for devices comprising a matrix comprising a polymer network and a non-gellable polysaccharide having oxygen and optionally active agents incorporated therein. The matrix may be formed into any desired shape for treatment of compromised tissue or for delivery of oxygen to a localized environment.Type: GrantFiled: December 29, 2000Date of Patent: March 25, 2014Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Bruce L. Gibbins, Lance D. Hopman
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Patent number: 8679528Abstract: The present invention relates to a hemostatic dressing which comprises a plurality of layers that contain resorbable materials and/or coagulation proteins. In particular, the invention includes dressings in which a layer of thrombin is sandwiched between a first and second layer of fibrinogen and wherein the layer of thrombin is not coextensive with the first and/or second layer of fibrinogen. The hemostatic dressings are useful for the treatment of wounded tissue.Type: GrantFiled: September 28, 2012Date of Patent: March 25, 2014Assignee: American National Red CrossInventors: Martin J. MacPhee, Dawson Beall, Stanley Friedman
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Patent number: 8680182Abstract: The present invention provides methods of promoting the revascularization and/or reenervation of central nervous system lesions using an in-situ crosslinkable hydrogel. The present invention also provides methods of treating a spinal cord injury by topically delivering to the spinal cord injury site a vehicle comprising a neurotrophic factor and/or anti-inflammatory agent. Also provided are methods of treating a spinal cord injury by topically administering or delivering a hydrogel to the injury site.Type: GrantFiled: April 13, 2012Date of Patent: March 25, 2014Assignees: Clemson University Research Foundation, MUSC Foundation for Research DevelopmentInventors: Xing Jin, Xuejun Wen, Vibhor Krishna, Ning Zhang
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Patent number: 8673344Abstract: The present invention relates to a solid dosage form with at least one film, which contains an active substance at least in sections, and the concentration of the active substance in the film or in the films has a gradient in a direction normal to the thickness of film. The invention further relates to a method of producing a solid dosage form, in which at least one film is produced, containing an active substance at least in sections, with the concentration of the active substance having a gradient in the longitudinal direction of the film.Type: GrantFiled: November 12, 2007Date of Patent: March 18, 2014Assignee: Abbvie Deutschland GmbH & Co. KGInventors: Jörg Rosenberg, Jörg Breitenbach, Peter Heilmann, Helmuth Steininger
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Patent number: 8673335Abstract: Compositions and methods for sealing, coating and adhering tissues are provided that utilize a polymeric system comprising at least a Polymer and a crosslinking agent; and, optionally, (i) a Gelation Disrupting Agent, (ii) an Augmentative Polymer or Monomer, (iii) an Adjunct Compound (iv) an Antimicrobial Agent (v) an Adhesion Enhancer, (vi) a Crosslink Augmentating Agent or any combination thereof. Additionally, a Therapeutic Agent may be incorporated.Type: GrantFiled: September 13, 2007Date of Patent: March 18, 2014Assignee: Southeastern Medical Technologies, LLCInventors: Curtis E. Jones, John P. Kennedy
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Patent number: 8673345Abstract: A kit and methods for delivering an effective amount of a labile active to the skin are provided. The kit and methods comprise a composition comprising an effective amount of a labile active agent incorporated into a water-soluble polymeric film and an additive composition capable of dissolving the water-soluble polymeric film.Type: GrantFiled: January 3, 2008Date of Patent: March 18, 2014Assignee: E-L Management Corp.Inventors: Andrew J. Bevacqua, Peter J. Lentini, Tracy N. Keeler, Julius R. Zecchino, Pauline Vassiliou
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Patent number: 8664280Abstract: A kit for forming a bioerodible composition is provided with a first aliquot portion of a reaction mixture having an aldehydic polymer solution, and a second aliquot portion of a reaction mixture having solids which include a cross-linking hydrazide. When mixed, the first and second aliquot portions of the reaction mixture react at a pH of 4 to 6 to form a solidified bioerodible composition within about 1 to about 10 minutes, to form a hydrazide cross-linked aldehydic polymer matrix. The bioerodable composition may be usefully employed to seal and/or treat wounds (e.g., a surgical incision).Type: GrantFiled: April 22, 2013Date of Patent: March 4, 2014Assignee: Royer Biomedical, Inc.Inventor: Garfield P. Royer
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Patent number: 8658201Abstract: A rapidly dissolving film is provided for delivery of an active agent to a moist body surface, e.g., mucosal tissue. The film comprises a film-forming binder, a rapidly dissolving polymeric material, and an active agent.Type: GrantFiled: January 31, 2005Date of Patent: February 25, 2014Assignees: Corium International, Inc., A.V. Topchiev Institute of Petrochemical Syntheses, Russian Academy of SciencesInventors: Parminder Singh, Sri Mudumba, Danir R. Bairamov, Valery G. Kulichikhin, Mikhail M. Feldstein, Gary W. Cleary
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Patent number: 8652509Abstract: A pharmaceutical composition and method for topical wound treatment by topical treatment with gallium salts, preferably gallium nitrate. In a preferred embodiment, the gallium nitrate is in an aqueous form without coagulation inhibitors such as citrate. The aqueous gallium salt formulation may be administered by a variety of methods including spraying, topical lotions, topical foams, and/or bandages containing or packaged with breakable ampoules of aqueous gallium salt formulations, and liquid bandage formulations. The aqueous gallium salt formulation may additionally contain other active and inactive ingredients, such as viscosity modifying agents, foaming agents, antiseptics, antibiotics, enzymes, fibrinogen, fibrin, polymers and growth factors.Type: GrantFiled: October 24, 2010Date of Patent: February 18, 2014Inventor: Moshe Rogosnitzky
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Publication number: 20140037711Abstract: The instant invention relates to a composition comprising at least one polymer having the structure A-B-A?, wherein A and A? may be the same or different and each is a degradable polyester component and wherein B is the reaction product resulting from the reaction between a diol, having one or more pendant oligomeric or polymeric groups, and A and A?. Additionally, the invention also relates to the development of a bioresorbable patch comprising: (a) an adhesion barrier component comprising a composition according to the invention in the form of a film; and (b) an adhesive component comprising: (i) at least one synthetic adhesive polymer; and/or (ii) at least one polysaccharide. The present invention provides a method of wound healing, comprising administering the composition or patch.Type: ApplicationFiled: October 20, 2011Publication date: February 6, 2014Applicant: DSM IP ASSETS B.V.Inventors: James Parakka, Ananth Iyer
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Publication number: 20140030315Abstract: A system for manufacturing an artificial construct suitable for transplantation into a biological organism that includes a two or three three-dimensional preform that is based on the actual two or three-dimensional structure of a native mammalian tissue; and an electrospinning apparatus, wherein the electrospinning apparatus is operative to deposit at least one layer of polymer fibers on the preform to form a polymer scaffold, and wherein the orientation of the fibers in the scaffold relative to one another is substantially parallel.Type: ApplicationFiled: January 14, 2013Publication date: January 30, 2014Inventor: Jed K. JOHNSON
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Patent number: 8628964Abstract: Isolated mixed populations of fetal pulmonary cells, engineered three-dimensional tissue constructs of these cells, and uses thereof in identifying therapeutic agents which augment, repair, and/or replace dysfunctional native lung and to perform in vitro studies such as pharmaceutical screening, models for lung development and disease and characterization of chemical or mechanical injury are provided.Type: GrantFiled: October 11, 2007Date of Patent: January 14, 2014Assignee: Drexel UniversityInventors: Peter I. Lelkes, Mark J. Mondrinos, Christine M. Finck
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Patent number: 8609129Abstract: A hemostatic agent composition, delivery system and method include a hemostatic agent composition which is inert and non-reactive relative to blood clotting proteins and platelets. The composition includes a clay material combined with a humectant in a stable suspension embedded in a mesh fabric and, when dried, is capable of accelerating the formation of a stable clot when applied to an actively bleeding wound or drying other bodily fluids.Type: GrantFiled: March 8, 2010Date of Patent: December 17, 2013Inventors: Jack Mentkow, Lisa Mentkow
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Patent number: 8597667Abstract: A system and methods are provided for targeted and individualized delivery of multiple skin benefit agents to the skin of a user. The image of a predetermined treatment area of the user's skin is first captured by an imaging device. The captured image data is then analyzed by a computing device to generate a unique skin profile for the user. Based on such skin profile, a printing device prints out one or more cosmetic delivery sheets that can be applied to the predetermined treatment area. Each of the cosmetic delivery sheets contains a substrate with multiple isolated, discrete regions, while at least two of the regions are imprinted with different skin benefit agents for treating different skin conditions of the predetermined treatment area according to the unique skin profile of the user.Type: GrantFiled: March 24, 2009Date of Patent: December 3, 2013Assignee: ELC Management LLCInventors: Tsung-Wei Robert Mou, Fatemeh Mohammadi, Lisa Qu, Tamar Lara Kamen, Anna Czarnota
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Publication number: 20130309295Abstract: Embodiments of the invention are based on the fermentation of bacteria to produce nano-cellulose in oxygen permeable tubular bioreactors. The resulting hydrogel non-hollow fiber can be stretched and dewatered to form strong, stiff yet flexible fiber. The fiber can be dehydrated by freeze drying or solvent exchange to form macroporous material and then optionally soaked with a solution of growth factors, anti-inflammatory drugs, and/or anitibacterial agents to provide a slow release drug delivery device in fiber form. The surface of the fiber is composed of nano-structured cellulose which promotes cell migration, tissue integration, and the healing process. BC fibers are not degraded in the human body and thus are well suited as reinforcement of implants and growing tissue. Uses for the BC fibers include surgical sutures, and reinforcing and promoting regeneration of damaged tissue or implants.Type: ApplicationFiled: February 6, 2012Publication date: November 21, 2013Inventor: Paul Gatenholm
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Patent number: 8557278Abstract: An apparatus for promoting the clotting of blood and controlling bleeding comprises a receptacle for retaining blood clotting material in particulate form therein. A pad for controlling bleeding comprises a mesh structure and a support attached to the mesh structure to facilitate the application of pressure to the pad and the wound. A bandage applicable to a bleeding wound comprises a mesh structure and a flexible substrate attached to the mesh structure, the substrate being a cloth or plastic member that may be adhesively attachable to cover a wound. In any embodiment, at least a portion of the receptacle or mesh structure is defined by a mesh having openings therein, and at least a portion of the particulate blood clotting material is in direct contact with blood. The mesh may include a zeolite powder impregnated or otherwise incorporated therein.Type: GrantFiled: August 27, 2012Date of Patent: October 15, 2013Assignee: Z-Medica, LLCInventors: Raymond J. Huey, Jeffrey L. Horn
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Patent number: 8541032Abstract: Disclosed are tissue graft compositions made of materials having different densities, methods of making, and methods of treatment for restoring tissues in a patient.Type: GrantFiled: October 11, 2012Date of Patent: September 24, 2013Assignee: ACell, Inc.Inventor: Miles Grody
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Patent number: 8524270Abstract: Disclosed is a biocompatible, hemostatic, cross-linked gelatin composition comprising a biocompatible material comprising cross-linked gelatin and a sufficient amount of wetting agent to permit uniform wetting of the sponge in the presence of an aqueous solution.Type: GrantFiled: May 22, 2012Date of Patent: September 3, 2013Assignee: Boston Scientific Scimed, Inc.Inventor: Richard J. Greff
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Patent number: 8512743Abstract: An apparatus for promoting the clotting of blood and controlling bleeding comprises a receptacle for retaining molecular sieve material in particulate form therein. A pad for controlling bleeding comprises a mesh structure and a rigid or semi-rigid support attached to the mesh structure to facilitate the application of pressure to the pad and the wound. A bandage applicable to a bleeding wound comprises a mesh structure and a flexible substrate attached to the mesh structure, the substrate being a cloth or plastic member that may be adhesively attached to cover a wound. In any embodiment, at least a portion of the receptacle or mesh structure is defined by a mesh having openings therein, and at least a portion of the particulate molecular sieve material is in direct contact with blood.Type: GrantFiled: August 29, 2012Date of Patent: August 20, 2013Assignee: Z-Medica, LLCInventors: Jeffrey Horn, Raymond Huey
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Patent number: 8512740Abstract: A fibrin wound dressing is made by mixing quantities of fibrinogen solution and thrombin solution with air. The resulting foam is very light weight, and with the proper attention to the amount of thrombin, will rest on a vertical surface without dripping. The wound dressing may also be formulated for its ability to continue migration of healing substances, such as PDGF, from the dressing to the wound site. Thrombin substitutes, such as other clotting proteins, may be used instead of thrombin. The resulting foam may also be lyophilized or ground and lyophilized for later reconstitution. A therapeutic drug or other additive may also be added to the wound dressing. A fibrin foam may be made by injecting fibrinogen foam into a clotting protein, such as thrombin.Type: GrantFiled: March 26, 2008Date of Patent: August 20, 2013Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventor: Yves A. Delmotte
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Patent number: 8496959Abstract: Methods, system and compositions for making and using a bioresorbable linked dressing made of bioresorbable microspheres in various configurations are provided for use in applying reduced pressure to a wound site. The methods include manufacture of a bioresorbable dressing comprising a casing and bioresorbable microspheres in the form of a rope shape. Further, the casing of the dressing comprises pores formed by a porogen system that may be activated by external to the wound or formed in situ within the wound site. The shape of the dressing allows the dressing to be placed into the wound site such that it fills the shape and size of the wound. Embodiments include formation of various rope dressing and their use in conjunction with reduced pressure therapy.Type: GrantFiled: August 13, 2012Date of Patent: July 30, 2013Assignee: KCI Licensing, Inc.Inventors: Archel Ambrosio, Joanna Payne
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Publication number: 20130183366Abstract: A sheet preparation characterized by that fibrinogen is held on one surface of a sheet-shaped support and thrombin is held on the other surface of the sheet-shaped support where fibrinogen is not held and that fibrinogen and thrombin are held separately from each other, and a process for preparing the same.Type: ApplicationFiled: July 14, 2011Publication date: July 18, 2013Applicant: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTEInventors: Hideki Saga, Tsutomu Hamuro
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Patent number: 8470362Abstract: Methods for sealing a puncture communicating with a blood vessel are provided that include introducing a porous carrier formed from lyophilized hydrogel or other material into the puncture. The plug may include at least first and second hydrogel precursors and a pH adjusting agent carried by the porous carrier in an unreactive state prior to exposure to an aqueous physiological environment. Once exposed to bodily fluids, the carrier expands as the lyophilized material hydrates to enhance and facilitate rapid hemostasis of the puncture. When the plug is placed into the puncture, the natural wetting of the plug by bodily fluids (e.g., blood) causes the first and second precursors to react and cross-link into an adhesive or “sticky” hydrogel that aids in retaining the plug in place within the puncture.Type: GrantFiled: September 7, 2010Date of Patent: June 25, 2013Assignee: AccessClosure, Inc.Inventors: Amarpreet S. Sawhney, Farhad Khosravi, Suresh S. Pai
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Patent number: 8460699Abstract: A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.Type: GrantFiled: August 23, 2012Date of Patent: June 11, 2013Assignee: Z-Medica, LLCInventors: Raymond J. Huey, Denny Lo, Daniel J. Burns, Giacomo Basadonna, Francis X. Hursey
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Patent number: 8445009Abstract: Disclosed are processes for preparing solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of a fibrinogen component and a fibrinogen activator. Also disclosed are methods for treating wounded tissue using these dressings and frozen and liquid compositions useful for preparing the haemostatic layer(s) of these dressings or for treating wounded tissue in a mammal.Type: GrantFiled: August 6, 2007Date of Patent: May 21, 2013Assignee: STB, LtdInventors: Martin MacPhee, Dawson Beall
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Publication number: 20130095229Abstract: A method of forming hemostatic sheets. Dextran and water are mixed to form a dextran-water mixture. The dextran-water mixture is formed into a first support layer. Fibrinogen and thrombin are mixed to form a fibrinogen and thrombin mixture. The fibrinogen and thrombin mixture is dispersed on the first support layer to form a hemostatic sheet.Type: ApplicationFiled: September 19, 2012Publication date: April 18, 2013Applicant: ST. TERESA MEDICAL, INC.Inventor: ST. TERESA MEDICAL, INC.
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Patent number: 8414922Abstract: The invention features sublingual film formulations of dopamine agonists and methods of treating Parkinson's disease, tremors, restless leg syndrome, sexual dysfunction, and depressive disorders therewith.Type: GrantFiled: April 12, 2012Date of Patent: April 9, 2013Assignees: Cynapsus Therapeutics, Inc., ARx, LLCInventors: Nathan John Bryson, Anthony John Giovinazzo, Scott David Barnhart, Michael Clinton Koons
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Publication number: 20130084323Abstract: A hemostat comprises a non-porous patch made of a bio-resorbable tissue compatible material, said patch having a tissue-facing surface and a top surface; an optional hemostatic agent that is disposed on said tissue-facing surface or optionally dispersed throughout said patch or optionally as a separate carrier layer, and at least one aperture or slit that penetrates said patch at least partially from said tissue-facing surface to said top surface.Type: ApplicationFiled: September 25, 2012Publication date: April 4, 2013Inventors: Jerome Riebman, Jeffrey Hammond, Kevin Weadock, John P. Matonick
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Patent number: 8409605Abstract: A kit for forming a biocompatible material provides a protein solution and a polymer solution including a derivative of a hydrophilic polymer with a functionality of at least three. Upon mixing. the protein solution and the polymer solution cross-link to form a non-liquid, three-dimensional network that degrades over time back to a liquid form. The polymer includes a degradation control region selected to achieve a desired degradation period and a cross-linking group selected to achieve a desired cross-linking period. The kit provides instructions for forming a mixture of the protein solution and polymer solution and for applying the mixture. The mixture serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.Type: GrantFiled: June 3, 2009Date of Patent: April 2, 2013Assignee: Neomend, Inc.Inventors: Olexander Hnojewyj, Charles F. Milo, Gregory M Cruise
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Patent number: 8404273Abstract: A variety of article and systems including wound care systems, methods for making the wound care systems, bactericidal, and methods for treating wounds using these systems are disclosed. The wound care systems may include a first material comprising one or more fibers or porous media. The one or more fibers or porous media may be coated with a second material that is capable of inhibiting the growth of bacteria and killing the bacteria to render the wound care system sterile, increasing the absorbency of the first material, or both upon exposure to light. The first material may be cotton, or any suitable fibrous material, the second material may be TiO2, and the light may be UV or visible light. A variety of methods including ALD may be used to coat the first material.Type: GrantFiled: April 23, 2010Date of Patent: March 26, 2013Assignee: Old Dominion University Research FoundationInventors: Helmut Baumgart, Diefeng Gu
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Patent number: 8388994Abstract: The present invention relates to biocompatible non-woven fibrous materials having a nano-micro topography and methods for producing such materials. The materials may be used to cover implantable medical devices and to fabricate a three-dimensional drug-eluting fibrous matrix featuring accurate spatial positioning of the drug particles within the matrix.Type: GrantFiled: June 9, 2009Date of Patent: March 5, 2013Inventors: Ingo Scheer, Claudia Beaumont
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Patent number: 8383104Abstract: The invention relates to a thrombin-free, fibrinogen-based biological adhesive for therapeutic use, which comprises factor VIIa and a source of calcium ions. The invention also relates to the use of the biological adhesive as a medicament, in particular as a dressing for biological tissues, wounds or biomaterials.Type: GrantFiled: December 15, 2006Date of Patent: February 26, 2013Assignee: Laboratoire Francais du Fractionnement et des Biotechnologies S.A.Inventor: Abdessatar Chtourou
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Patent number: 8383147Abstract: The present invention is directed to a reinforced absorbable hemostat comprising at least one hemostatic agent in a single layer of nonwoven synthetic fabric having a mixture of compressed fiber staples of a polyglycolide/polylactide copolymer and a polydioxanone.Type: GrantFiled: August 22, 2012Date of Patent: February 26, 2013Assignee: Ethicon, Inc.Inventors: Dhanuraj S. Shetty, Olajompo Moloye-Olabisi, Robert W. Van Holten, Degang Zhong
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Patent number: 8383148Abstract: A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.Type: GrantFiled: June 18, 2012Date of Patent: February 26, 2013Assignee: Z-Medica, LLCInventors: Raymond J. Huey, Denny Lo, Daniel J. Burns, Giacomo Basadonna, Francis X. Hursey
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Patent number: 8349355Abstract: The present invention relates to novel formulations comprising lipoic acid and hyaluronic acid and/or the derivatives thereof for use in the repair of chronic ulcers, the regeneration of damaged skin, the prevention of skin aging and, when administered by the systemic route, to treat peripheral neuropathies and intoxications by chemical and/or biological agents.Type: GrantFiled: May 24, 2006Date of Patent: January 8, 2013Assignee: Anika Therapeutics S.R.L.Inventors: Carlo Soranzo, Doriana Senigaglia, Davide Bellini
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Patent number: 8343537Abstract: A hemostatic device for promoting the dotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood emanating from the wound to cause the clotting. A bandage that can be applied to a bleeding wound to promote the clotting of blood includes a flexible substrate and a gauze substrate mounted thereon. The gauze substrate includes a clay material and a polyol. A hemostatic sponge also includes a gauze substrate and a dispersion of hemostatic material and a polyol on a first surface of the substrate.Type: GrantFiled: January 31, 2012Date of Patent: January 1, 2013Assignee: Z-Medica, LLCInventors: Raymond J. Huey, Denny Lo, Daniel J. Burns, Giacomo Basadonna, Francis X. Hursey
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Patent number: 8329734Abstract: The invention is directed to formulations and methods of treating a migraine and/or cluster headache with a serotonin agonist, pharmaceutically acceptable salt thereof, or derivative thereof.Type: GrantFiled: July 27, 2009Date of Patent: December 11, 2012Assignee: AFGIN Pharma LLCInventor: Ronald Aung-Din
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Patent number: 8329211Abstract: The present invention is directed to a synthetic fabric comprising a multi-layered nonwoven fabric made from staples of a polyglycolide/polylactide copolymer, each layer having a different density. The multi-layer fabric can be used as a reinforced absorbable hemostat medical device.Type: GrantFiled: May 17, 2010Date of Patent: December 11, 2012Assignee: Ethicon, Inc.Inventors: Olajompo Moloye-Olabisi, Dhanuraj S. Shetty, Robert W. Van Holten, Degang Zhong
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Patent number: 8323675Abstract: A soft tissue prosthesis for repairing a defect of an abdominal wall or a pelvic cavity wall, comprising: a three-dimensional mesh sheet comprising at least two types of yarn interlooped or intertwined to define at least two layers, wherein one of the at least two layers is substantially non-biodegradable and porous to allow for tissue ingrowth and another of the at least two layers is substantially biodegradable; and an adhesion barrier in the form of a film, foam or gel, the adhesion barrier polymerized to, and entrapping therein, at least some of the yarns of the substantially biodegradable layer, the substantially biodegradable layer making a connection between the adhesion barrier and the substantially non-biodegradable layer to decrease the likelihood of delamination therefrom, the adhesion barrier being an external layer on a first side of the prosthesis and the substantially non-biodegradable layer being an external layer on the side of the prosthesis opposite the first side, the substantially biodegrType: GrantFiled: April 12, 2005Date of Patent: December 4, 2012Assignee: Genzyme CorporationInventor: Keith E. Greenawalt
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Patent number: 8298586Abstract: Disclosed are tissue graft compositions made of materials having different densities, methods of making, and methods of treatment for restoring tissues in a patient.Type: GrantFiled: July 22, 2009Date of Patent: October 30, 2012Assignee: Acell IncInventors: Rodney W. Bosley, Jr., Clay Fette
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Patent number: 8287900Abstract: There is provided a medicated patch including 5-methyl-1-phenyl-2-(1H)-pyridone. A medicated patch comprising a percutaneously absorbable preparation layer, wherein the percutaneously absorbable preparation layer includes 5-methyl-1-phenyl-2-(1H)-pyridone or a pharmaceutically acceptable salt thereof as an active component, a dissolving agent and an aqueous base material (or a rubber-type base material), and the active component is contained in an amount of 0.1 to 30 mass % relative to the total amount of the percutaneously absorbable preparation layer.Type: GrantFiled: May 26, 2008Date of Patent: October 16, 2012Assignees: Lead Chemical Co., Ltd., Shionogi & Co., Ltd.Inventors: Takayasu Matsuzawa, Tamaki Horiuchi, Seijiro Yama, Tetsukazu Hamamoto, Sunao Takeuchi, Daisuke Ichimatsu
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Patent number: 8273368Abstract: Methods, system and compositions for making and using a bioresorbable linked dressing made of bioresorbable microspheres in various configurations are provided for use in applying reduced pressure to a wound site. The methods include manufacture of a bioresorbable dressing comprising a casing and bioresorbable microspheres in the form of a rope shape. Further, the casing of the dressing comprises pores formed by a porogen system that may be activated by external to the wound or formed in situ within the wound site. The shape of the dressing allows the dressing to be placed into the wound site such that it fills the shape and size of the wound. Embodiments include formation of various rope dressing and their use in conjunction with reduced pressure therapy.Type: GrantFiled: January 20, 2012Date of Patent: September 25, 2012Assignee: KCI Licensing, Inc.Inventors: Archel Ambrosio, Joanna Payne
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Patent number: 8273369Abstract: The present invention is directed to a reinforced absorbable hemostat comprising at least one hemostatic agent in a single layer of nonwoven synthetic fabric having a mixture of compressed fiber staples of a polyglycolide/polylactide copolymer and a polydioxanone.Type: GrantFiled: May 17, 2010Date of Patent: September 25, 2012Assignee: Ethicon, Inc.Inventors: Olajompo Moloye-Olabisi, Dhanuraj S. Shetty, Robert W. Van Holten, Degang Zhong
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Publication number: 20120226245Abstract: Disclosed is a transdermally absorbable preparation, in which an adhesive agent produced by crosslinking at least one copolymer is contained in an adhesive layer and the aging period in the production of the adhesive layer can be shortened. The transdermally absorbable preparation comprises a support and an adhesive layer arranged on the support and containing an adhesive agent and a medicinal component. The transdermally absorbable preparation is characterized in that the adhesive agent comprises a resin mixture comprising 100 parts by mass of a specific acrylic copolymer (A) and 0.1 to 30 parts by mass of a specific acrylic copolymer (B) or 0.05 to 2 part(s) by mass of a polyamine compound, and the adhesive layer additionally contains an organic acid.Type: ApplicationFiled: September 1, 2010Publication date: September 6, 2012Applicant: NIPRO PATCH CO., LTD.Inventors: Naohisa Kawamura, Chie Sugaya
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Publication number: 20120225111Abstract: The invention relates to a product for the management of inflammations, pressure sores and/or oral sores (aphthas) which is made predominantly, and preferably completely, from a bioresorbable material, with the bioresorbable material exhibiting a flexible and/or compressible pad element which adheres to the mucosa, and in particular being designed completely as a pad element.Type: ApplicationFiled: November 6, 2007Publication date: September 6, 2012Applicant: Lohmann & Rauscher GmbH & Co. KGInventor: Gert Hartmut Scholz
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Patent number: 8257732Abstract: A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.Type: GrantFiled: May 25, 2011Date of Patent: September 4, 2012Assignee: Z-Medica CorporationInventors: Raymond J. Huey, Denny Lo, Daniel J. Burns, Giacomo Basadonna, Francis X. Hursey
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Patent number: 8257731Abstract: An apparatus for promoting the clotting of blood and controlling bleeding comprises a receptacle for retaining molecular sieve material in particulate form therein. A pad for controlling bleeding comprises a mesh structure and a rigid or semi-rigid support attached to the mesh structure to facilitate the application of pressure to the pad and the wound. A bandage applicable to a bleeding wound comprises a mesh structure and a flexible substrate attached to the mesh structure, the substrate being a cloth or plastic member that may be adhesively attached to cover a wound. In any embodiment, at least a portion of the receptacle or mesh structure is defined by a mesh having openings therein, and at least a portion of the particulate molecular sieve material is in direct contact with blood.Type: GrantFiled: September 9, 2009Date of Patent: September 4, 2012Assignee: Z-Medica CorporationInventors: Jeffry Horn, Raymond Huey
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Patent number: 8252318Abstract: An apparatus for promoting the clotting of blood and controlling bleeding comprises a receptacle for retaining blood clotting material in particulate form therein. A pad for controlling bleeding comprises a mesh structure and a support attached to the mesh structure to facilitate the application of pressure to the pad and the wound. A bandage applicable to a bleeding wound comprises a mesh structure and a flexible substrate attached to the mesh structure, the substrate being a cloth or plastic member that may be adhesively attachable to cover a wound. In any embodiment, at least a portion of the receptacle or mesh structure is defined by a mesh having openings therein, and at least a portion of the particulate blood clotting material is in direct contact with blood. The mesh may include a zeolite powder impregnated or otherwise incorporated therein.Type: GrantFiled: November 2, 2006Date of Patent: August 28, 2012Assignee: Z-Medica CorporationInventors: Raymond J. Huey, Jeffrey L. Horn
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Patent number: 8252317Abstract: The present invention provides novel metal alginates prepared from non-cross-linked alginate monomers such as sodium alginate and an aqueous solution of a group 4, 5, or 6 metal oxyhalide. The novel group 4, 5, and 6 metal alginates are useful in the preparation of cell culture supports, exhibit useful X-ray contrast properties, and exhibit unanticipated stability to standard autoclave conditions relative to known metal alginates such as calcium alginate. In general, the novel metal alginates provided by the present invention offer features and properties not observed in known metal alginates such as calcium or barium alginates.Type: GrantFiled: February 26, 2009Date of Patent: August 28, 2012Assignee: General Electric CompanyInventors: Andrew Soliz Torres, Peter John Bonitatibus, Jr.
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Publication number: 20120177719Abstract: A device including a body (12) including fibers without oxidized cellulose. The body (12) also includes fibers containing oxidized cellulose.Type: ApplicationFiled: December 9, 2011Publication date: July 12, 2012Applicant: Perouse MedicalInventors: Vithuy Dao, Robert Michelot, Eric Perouse