Synthetic Polymer Patents (Class 424/486)
-
Patent number: 8795730Abstract: Compositions are provided for promoting healing of tissue of a vertebrate organism. The compositions can be for internal administration of a therapeutically effective amount of pharmacologically active, protease inhibiting, aqueous media soluble polysulfonated materials in salt form and associated with a secondary material to reduce one or more of inflammation, bacterial proliferation, proteolytic activity, and cancerous cell growth. The compositions may additionally or alternatively be cross-linked so as to alter the solubility of these pharmacologically active salts or slow dissolution by providing biodegradable cross-linkers. Compositions for healing the tissue of a multicellular organism are provided that can include a polysulfonated material in a liquid mixture, as solid particles or constructs that may or may not biodegrade or deliver a pharmacologically relevant value.Type: GrantFiled: January 19, 2010Date of Patent: August 5, 2014Inventor: David John Vachon
-
Publication number: 20140212493Abstract: A composition including an association complex of a pharmaceutical composition and one or more polyethylene-polypropylene glycol block copolymers (poloxamers) is provided. The pharmaceutical composition may include a member selected from the group consisting of (a) an association complex of an eprosartan composition including eprosartan or a pharmaceutically acceptable salt of eprosartan and (b) the non-zwitterionic compound 2-(7-chloro-S-methyl-4-oxo-3-phenyl-4,S dihydro-3H-pyridazino (4,S-b)indol-1-yl)N, N-dimethylacetamide (NZ).Type: ApplicationFiled: April 2, 2014Publication date: July 31, 2014Applicant: BVM Holding Co.Inventors: Ketan Mehta, Yu-Hsing Tu
-
Publication number: 20140212355Abstract: It is provided herein methods, devices, and compositions for trans-arterial local delivery of therapeutic agent for the treatment of liver cancers.Type: ApplicationFiled: January 28, 2013Publication date: July 31, 2014Applicant: Abbott Cardiovascular Systems Inc.Inventors: Mikael TROLLSAS, Syed Hossainy, John Stankus, Paul Consigny
-
Patent number: 8790700Abstract: An aqueous liquid suspension containing a coated drug-ion exchange resin complex comprising a core composed of an amphetamine complexed with a pharmaceutically acceptable ion-exchange resin and an uncoated amphetamine-ion exchange resin complex is provided. The coated amphetamine-ion exchange resin complex is in admixture with a polymer to form a matrix. The coating is a polyvinyl acetate polymer and a plasticizer. Methods of making the coated complex and the liquid suspension are described.Type: GrantFiled: October 2, 2013Date of Patent: July 29, 2014Assignee: TRIS Pharma, Inc.Inventors: Ketan Mehta, Yu-Hsing Tu
-
Patent number: 8791150Abstract: Block copolymer pharmaceutical compositions containing 3,3?-diindolylmethane (DIM). The pharmaceutical composition for peroral administration comprises 3,3?-diindolylmethane as an active component and a target additive, the target additive being a block copolymer of oxyethylene and oxypropylene, in which the content of the hydrophobic oxypropylene block is less than 50 mass % and the molecular mass of the hydrophilic oxyethylene block is equal to 2,250 Da or more, at a ratio of the active component to the selected block copolymer varying between 1:2 and 1:10. The composition improves absorption of the active compound by the bloodstream upon peroral delivery.Type: GrantFiled: September 7, 2010Date of Patent: July 29, 2014Assignee: Zakrytoe Aktsionernoe Obschestvo “Veles Farma”Inventors: Vsevolod Ivanovich Kiselev, Irina Gennadievna Vassilieva
-
Publication number: 20140199244Abstract: The present invention relates to controlled release systems that may be administered other than intravenously. The controlled release system is directed to active ingredients, entrapped in or otherwise incorporated in or coupled to polymer carriers or polymeric devices, such as micelles, nanoparticles, microspheres and other types of polymer devices for controlled release; the active ingredients are covalently bonded to the polymer carriers or polymeric devices. The controlled release systems may suitably be used to treat diseases.Type: ApplicationFiled: June 26, 2012Publication date: July 17, 2014Applicant: CRISTAL DELIVERY B.V.Inventors: Cristianne Johanna Ferdinand Rijcken, Martin Stigter, Josephus Johannes Maria Holthuis
-
Patent number: 8778396Abstract: This invention relates to an orally administrable, gastroretentive pharmaceutical dosage form which contains at least one pharmaceutically active ingredient and at least one polymeric adjuvant. The adjuvant serves to retain the dosage form in a selected region of the gastrointestinal tract for sufficient time for the pharmaceutically active ingredient to be released and absorbed. Ideally the dosage form will contain two or more pharmaceutically active ingredients which are delivered to different regions of the gastrointestinal tract.Type: GrantFiled: June 3, 2009Date of Patent: July 15, 2014Assignee: University of the Witwatersrand, JohannesburgInventors: Viness Pillay, Yahya Choonara, Caragh Murphy, Sarashnee Moonisami
-
Patent number: 8771738Abstract: Method of forming tissue adhesives by reacting an oxidized polysaccharide with a water-dispersible multi-arm polyether amine, wherein at least three of the arms are terminated by primary amine groups, are disclosed. The use of the tissue adhesives for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; drug delivery; anti-adhesive applications; and as a bulking agent to treat urinary incontinence are described.Type: GrantFiled: March 8, 2013Date of Patent: July 8, 2014Assignee: Actamax Surgical Materials, LLCInventors: George K. Kodokian, Samuel David Arthur
-
Patent number: 8771720Abstract: Polyhydroxyalkanoates (PHAs) from which pyrogen has been removed are provided. PHAs which have been chemically modified to enhance physical and/or chemical properties, for targeting or to modify biodegradability or clearance by the reticuloendothelial system (RES), are described. Methods for depyrogenating PHA polymers prepared by bacterial fermentation processes are also provided, wherein pyrogens are removed from the polymers without adversely impacting the polymers' inherent chemical structures and physical properties. PHAs with advantageous processing characteristics, including low melting points and/or solubility in non-toxic solvents, are also described. The PHAs are suitable for use in in vivo applications such as in tissue coatings, stents, sutures, tubing, bone, other prostheses, bone or tissue cements, tissue regeneration devices, wound dressings, drug delivery, and for diagnostic and prophylactic uses.Type: GrantFiled: July 10, 2012Date of Patent: July 8, 2014Assignee: Metabolix, Inc.Inventors: Simon F. Williams, David P. Martin, Tillman Gerngross, Daniel M. Horowitz
-
Patent number: 8771713Abstract: The present invention includes compositions, methods, systems for the controlled delivery of an active agent in a tablet polymer comprising two or more layers, wherein each of the two or more layers comprises at least one active agent and at least one molecular recognition polymer, wherein the two or more layers are compressed into a single tablet.Type: GrantFiled: March 3, 2009Date of Patent: July 8, 2014Assignee: Board of Regents, The University of Texas SystemInventors: Nicholas A. Peppas, Barbara Ekerdt, Marta Gomez-Burgaz
-
Publication number: 20140186441Abstract: A biocompatible, resorbable composite for osteosynthesis includes osteoconductive particles dispersed within a porous polymer matrix having a plurality of fluid passageways that expose at least a portion of a plurality of the osteoconductive particles to an exterior of the polymer matrix. The composite may further include a chemical additive incorporated within the polymer matrix, the chemical additive being configured to modify one or more of acidity, degradation rate, melting point, hydrophilicity, and hydrophobicity of the polymer matrix. A method for making the composite includes mixing the osteoconductive particles with polymer material and the chemical additive to form a mixture and treating the mixture to bind the osteoconductive particles with the polymer material to create a solid unit.Type: ApplicationFiled: March 13, 2013Publication date: July 3, 2014Applicant: DePuy Synthes Products, LLCInventors: Stefan Beck, Lorenz Niederberger, Nico Stohler
-
Patent number: 8758803Abstract: Water-soluble, solid, film-shaped preparations comprising at least one film-forming polymer selected from the group consisting of the fully and partially hydrolyzed polyvinyl alcohols, and at least one water-insoluble, oily liquid which is incorporated into the film-forming polymer and amounts to at least 30 percent by weight, relative to the dry portion of the preparation. Methods for producing the preparations and the use thereof are also provided.Type: GrantFiled: April 30, 2009Date of Patent: June 24, 2014Assignee: LTS Lohmann Therapie-Systeme AGInventors: Markus Müller, Holger Piotrowski
-
Patent number: 8747820Abstract: The biodegradable drug delivery systems described here are formulated for implantation into the nail unit and its surrounding tissues for the treatment of various nail unit conditions. The systems include non-temperature dependent phase change compositions that may be formulated as solutions, solids, semisolids, microparticles, or crystals.Type: GrantFiled: October 23, 2013Date of Patent: June 10, 2014Assignee: Hallux, Inc.Inventors: Frank Kochinke, Corinne Bright
-
Publication number: 20140154321Abstract: An injectable drug delivery includes a core containing one or more drugs and one or more polymers. The core may be surrounded by one or more polymer outer layers (referred to herein as “coatings,” “skins,” or “outer layers”). In certain embodiments, the device is formed by extruding or otherwise preforming a polymeric skin for a drug core. The drug core may be co-extruded with the skin, or inserted into the skin after the skin has been extruded, and possibly cured. In other embodiments, the drug core may be coated with one or more polymer coatings. These techniques may be usefully applied to fabricate devices having a wide array of drug formulations and skins that can be selected to control the release rate profile and various other properties of the drugs in the drug core in a form suitable for injection using standard or non-standard gauge needles.Type: ApplicationFiled: November 27, 2013Publication date: June 5, 2014Applicant: PSIVIDA US, INC.Inventor: Paul Ashton
-
Patent number: 8741316Abstract: The present invention includes compositions, methods, systems of making a composition that includes one or more active agent; a recognitive polymeric matrix; and a porosigen, wherein the composition comprises a porous recognitive, swellable hydrogel that dissociates under conditions of low water or humidity.Type: GrantFiled: December 4, 2008Date of Patent: June 3, 2014Assignee: Board of Regents, The University of Texas SystemInventors: Nicholas A. Peppas, Aditya Durgam
-
Patent number: 8734851Abstract: The present invention provides implantable medical devices coated with polyelectrolyte assemblies that are fabricated by layer-by-layer deposition of nucleic acid and polycation. Such devices facilitate the local delivery of a nucleic acid contained in the polyelectrolyte assembly into a cell or tissue at an implantation site. Also provided are methods of fabricating and using implantable medical devices according to the invention.Type: GrantFiled: May 1, 2006Date of Patent: May 27, 2014Assignee: Wisconsin Alumni Research FoundationInventors: David M. Lynn, Jingtao Zhang, Christopher M. Jewell, Nathaniel J. Fredin
-
Patent number: 8734819Abstract: An article, such as a container or bag for garbage, or electrical wiring insulation, which repels animals such as cats, dogs, rodents, and crows. The article is made from a synthetic resin composition including a thermoplastic polymer, and from 10 to 15,000 ppm by weight of an odorant compound such as a salicylic acid ester, menthol, corn mint oil, eucalyptus oil, and camphor, and combinations thereof. The resin composition may comprise more than one thermoplastic polymer, polyethylene and ethylene/vinyl acetate copolymer being preferred first and second thermoplastic polymers, respectively. In a method for forming the synthetic resin composition, the compound is added to the second polymer in a ratio of about 1:2 parts by weight to form a master blend that then is added to an amount of the first polymer at a master blend percentage of about 1.5%.Type: GrantFiled: June 24, 2010Date of Patent: May 27, 2014Inventors: Joseph A. Dussich, Jr., Jeffrey A. Dussich, James A. Dussich, Joseph A. Dussich, III
-
Patent number: 8734828Abstract: A cell-free graft contains (i) a cohesive, scaffold-forming matrix with open porosity containing a biologically and pharmaceutically acceptable material, and (ii) a gel of a biologically and pharmaceutically acceptable material. The cell-free graft is produced by (v) contacting the matrix with the gel, and (vi) drying the matrix-gel complex formed in (v). The cell-free graft can be used for covering and increasing the viscoelasticity of defects, for tissue regeneration and in particular for regenerating mesenchymal tissue, especially cartilage and/or bone.Type: GrantFiled: April 6, 2009Date of Patent: May 27, 2014Assignee: BioTissue AGInventors: Christian Kaps, Eszter Tanczos
-
Patent number: 8734843Abstract: The present invention provides theophylline sustained release particles which contain a polyglycerol fatty acid ester as a matrix base material, which have a homogenous nucleus particle structure, which can effectively mask the unpleasant taste of medicaments, and which exhibit an excellent sustained medicament releasability (dissolvability) and outstanding storage stability. In particular, the present invention provides, among other things, a method for preparing theophylline sustained release particles comprising the steps of heating a matrix base material containing a polyglycerol fatty acid ester, theophylline and ethyl cellulose to give a molten mixture; spray-cooling the molten mixture to obtain spherical core particles having an average particle diameter of 250 ?m or less; and applying fine particles to the core particles by fusion coating.Type: GrantFiled: June 17, 2004Date of Patent: May 27, 2014Assignee: Otsuka Pharmaceutical Co., Ltd.Inventor: Yuso Tomohira
-
Patent number: 8734772Abstract: Disclosed herein are cosmetic compositions comprising (a) at least one styrene-maleic anhydride copolymer bearing at least one group chosen from styrylpyridine and styrylpyridinium groups and (b) at least one co-film forming agent and/or at least one plasticizer. The cosmetic composition optionally further comprises at least one pigment and at least one solvent. Also disclosed herein are methods for making up and/or enhancing the appearance of a keratinous substrate comprising (1) forming a film on the keratinous substrate by applying to said keratinous substrate a cosmetic composition comprising (a) at least one styrene-maleic anhydride copolymer bearing at least one group chosen from styrylpyridine and styrylpyridinium groups and (b) at least one co-film forming agent and/or at least one plasticizer and (2) exposing the film to radiation chosen from UV and visible light radiation.Type: GrantFiled: December 28, 2012Date of Patent: May 27, 2014Assignee: L'OrealInventors: XianZhi Zhou, Jean-Thierry Simonnet, Hy Si Bui, Chunhua Li
-
Publication number: 20140141079Abstract: An orally deliverable pharmaceutical composition comprises a therapeutically effective amount of pramipexole or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient, said composition exhibiting at least one of (a) an in vitro release profile wherein on average no more than about 20% of the pramipexole is dissolved within 2 hours after placement of the composition in a standard dissolution test; and (b) an in vivo pramipexole absorption profile following single dose administration to healthy adult humans wherein the time to reach a mean of 20% absorption is greater than about 2 hours and/or the time to reach a mean of 40% absorption is greater than about 4 hours. The composition is useful for oral administration, not more than once daily, to a subject having a condition or disorder for which a dopamine receptor agonist is indicated.Type: ApplicationFiled: January 28, 2014Publication date: May 22, 2014Applicant: Pharmacia CorporationInventors: Ernest J. Lee, Gerard M. Bredael, John R. Baldwin, Steven R. Cox, Mark J. Heintz
-
Patent number: 8729242Abstract: Methods for reducing the T-cell mitogenicity of lectin compositions are provided. In one aspect this is achieved by chemically modifying mitogenic lectin compositions under optimized conditions. Additionally or alternatively, the reduction in T-cell mitogenicity is achieved by removing unmodified subunits chemically modified mixtures. Modified lectin compositions with reduced T-cell mitogenicity are also provided as are uses of the inventive compositions.Type: GrantFiled: January 27, 2010Date of Patent: May 20, 2014Assignee: Smartcells, Inc.Inventors: Thomas M. Lancaster, Wenyi Cai, Ryan Faucette, Matthew Pecukonis, Todd C. Zion
-
Patent number: 8722024Abstract: Gels of isopropyl esters of fatty alcohols that include a dimethyl/methylhydrogensiloxane copolymer, a silanol-terminated PDMS or an ethenyl-terminated PDMS, and a hydride functional siloxane. Also provided are methods for making the gels and articles containing them.Type: GrantFiled: March 12, 2010Date of Patent: May 13, 2014Assignee: Jeen International CorporationInventors: Juan Mateu, Adam Perle
-
Patent number: 8722749Abstract: A method for producing foams, such as sponges, from hydrocolloids is described. A solid or semi-solid gel is formed by dissolving polymeric material in an aqueous solvent. The gel formed is allowed to set, and may optionally then be cut into the desired shape. The gel may be frozen to allow formation of ice crystals to act as porogens. Subsequently, the gel is exposed to a radiant energy field for drying under vacuum. This causes the solvent to boil and the foam or sponge is formed. Medicinally active ingredients may be included in the process, so that the sponge or foam formed contains the active ingredient dispersed within the structure. The method described provides an alternative to the conventional methods of particulate leaching or freeze drying.Type: GrantFiled: July 29, 2005Date of Patent: May 13, 2014Assignee: Enwave CorporationInventors: Timothy D. Durance, Jaya Sundaram, Mareike Ressing
-
Patent number: 8722066Abstract: The present invention provides, compositions, devices, and methods for affecting, among other things, weight loss and/or weight control, by sequestering nutrients or other compounds such as toxins from absorption in the digestive tract. The compositions, devices, and methods employ one or more members made of a compressible, absorbent matrix material. In various embodiments, the matrix material is suitable for routine use. The compressible absorbent matrix material has a size, shape and/or geometry configured for efficient packing into a small space, and/or configured to absorb and substantially retain digested material in the stomach. The devices and compositions may further comprise one or more hydrogel(s), soluble or insoluble fibers, waxes and/or gums to provide the desired mechanical properties and/or absorptive or shielding properties.Type: GrantFiled: March 27, 2012Date of Patent: May 13, 2014Assignee: Primigenia, LLCInventor: Paolo Costa
-
Publication number: 20140127292Abstract: Oral pharmaceutical compositions for the controlled release of heparin or derivatives thereof, for example dalteparin, salts and/or derivatives thereof, comprising (a) a matrix consisting of amphiphilic compounds and lipophilic compounds with melting point lower than 90° C. in which the active ingredient is at least partially dispersed; (b) an outer hydrophilic matrix in which the lipophilic/amphiphilic matrix is dispersed; (c) optionally, other excipients suitable for solid pharmaceutical forms. The treatment of inflammatory bowel diseases (IBD) by administering to a patient in need thereof an effective amount of dalteparin, salts and/or derivatives thereof is also disclosed.Type: ApplicationFiled: December 30, 2013Publication date: May 8, 2014Applicant: Cosmo Technologies LimitedInventors: Mauro Ajani, Luigi Moro, Roberto Villa
-
Patent number: 8715710Abstract: A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.Type: GrantFiled: July 18, 2012Date of Patent: May 6, 2014Assignee: Heron Therapeutics, Inc.Inventors: Steven Y. Ng, Hui Rong Shen, Jorge Heller
-
Patent number: 8715711Abstract: This invention provides for novel antiparasitic and pesticidal forms of moxidectin, including a long-acting polymeric implant. The resulting compounds may be used in veterinary compositions which are used in treating, controlling and preventing of endo- and ectoparasite infections in animals.Type: GrantFiled: November 30, 2012Date of Patent: May 6, 2014Assignee: Merial LimitedInventors: Susan Mancini Cady, Baoqing Ma, Robert Clark Chapman, Chunhua Yang, Uday Jain
-
Patent number: 8715732Abstract: Methods and compositions are provided for producing nucleic acid-based compositions. Methods include enzyme catalyzed or nucleic acid polymer conjugation. Compositions include nucleic acid-containing hydrogels which can be elongated via rolling circle amplification. The hydrogels can encapsulate bioactive agents for drug delivery.Type: GrantFiled: January 5, 2010Date of Patent: May 6, 2014Assignee: Cornell UniversityInventors: Dan Luo, Jong Bum Lee, Hisakage Funabashi
-
Publication number: 20140120164Abstract: A pharmaceutical composition for controlled release of an active substance, the composition being a matrix composition of: (a) a substantially water soluble or crystalline polymer, (b) an active substance, and optionally, (c) one or more pharmaceutically acceptable excipients having a water solubility of at least 1 mg/ml at ambient temperature. The matrix composition does not contain a water dispersible or water soluble surface active agent that has at least one domain, which is compatible with the polymer in the matrix composition, and which substantially eliminates water diffusion between the interface between the polymer crystals.Type: ApplicationFiled: August 23, 2013Publication date: May 1, 2014Applicant: EGALET LTD.Inventors: Gina Fischer, Daniel Bar-Shalom, Lillian Slot, Anne-Marie Lademann, Christine Andersen
-
Patent number: 8709482Abstract: A pharmaceutical delivery device, such as a suppository or pessary, comprises a synthetic prostaglandin PGE1 analogue (e.g. misoprostol) in a solid polyurethane hydrogel.Type: GrantFiled: May 31, 2013Date of Patent: April 29, 2014Assignee: Ferring B.V.Inventor: Steven Robertson
-
Patent number: 8709481Abstract: A system for controlled release of an active principle, includes at least (a) a degradable polymer matrix which produces acid compounds and (b) at least one acid-sensitive complex of an active principle having at least one electrostatic charge and a complexing polyelectrolyte partner of opposite charge which complexes with the active principle. A method for preparation of such a system is described. The release of the active principle (7P) is prolonged over 18 days (ternary system PMLA/7P/PLAGA) in comparison to binary systems (7P/PLAGA) and (PMLA/7P).Type: GrantFiled: July 18, 2008Date of Patent: April 29, 2014Assignees: Centre National de la Recherche Scientifique, Univeriste de Montpellier 1Inventors: Michel Vert, Laurent Leclercq, Mahfoud Boustta
-
Publication number: 20140112990Abstract: The invention provides polymer compositions for cell and drug delivery.Type: ApplicationFiled: April 27, 2012Publication date: April 24, 2014Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Sidi A. Bencherif, David J. Mooney, David Edwards, Roger Warren Sands
-
Publication number: 20140112980Abstract: An abuse-resistant controlled release pharmaceutical composition comprising a pharmaceutically effective amount of discrete particles of an active capable of abuse, wherein surfaces of said particles are wetted with a water insoluble coating material, and preferably wherein said composition comprises a matrix, in which said particles are distributed, and which renders the abuse-capable compound within the matrix difficult to separate from the matrix; and a method for the preparation of a controlled release pharmaceutical composition having a reduced potential for abuse, comprising applying a pressure force to a mixture comprising a water insoluble material, and particles of a pharmaceutically active compound capable of inducing in a subject a reaction that is physiologically or psychologically detrimental if administered in an immediate release dosage form, thereby resulting in surface coated particles, and incorporating said surface coated particles into a pharmaceutical compositionType: ApplicationFiled: December 23, 2013Publication date: April 24, 2014Inventors: Farid Vaghefi, Gary G. Liversidge, Stephen B. Ruddy, Eugene R. Cooper
-
Patent number: 8703197Abstract: A branched polyamine comprises about 45 to about 70 backbone tertiary amine groups, about 90 to about 140 backbone secondary amine groups, a positive number n? greater than 0 of backbone terminating primary amine groups, and a positive number q greater than 0 of backbone terminating carbamate groups of formula (2): wherein (n?+q) is a number equal to about 45 to about 70, the starred bond of formula (2) is linked to a backbone nitrogen of the branched polyamine, L? is a divalent radical comprising 3 to 30 carbons, and q/(n?+q)×100% equals about 9% to about 47%.Type: GrantFiled: September 13, 2012Date of Patent: April 22, 2014Assignees: International Business Machines Corporation, Agency for Science, Technology and ResearchInventors: Wei Cheng, Daniel J. Coady, Amanda C. Engler, James L. Hedrick, Pei Yun Teo, Chuan Yang, Yi Yan Yang
-
Patent number: 8703194Abstract: There is presently provided a stimulus-responsive polymer comprising a biodegradable polymer backbone and a stimulus-responsive pendant group attached to the biodegradable polymer backbone, wherein the biodegradable polymer backbone comprises a poly(amino ester) or a poly(amido amine), the poly(amido amine) optionally comprising a disulfide linkage in the backbone.Type: GrantFiled: November 2, 2007Date of Patent: April 22, 2014Assignee: Agency for Science, Technology and ResearchInventors: Ye Liu, Decheng Wu, Chaobin He
-
Patent number: 8703196Abstract: A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.Type: GrantFiled: July 31, 2012Date of Patent: April 22, 2014Assignee: Bend Research, Inc.Inventors: Walter C. Babcock, William J. Curatolo, Dwayne T. Friesen, Rodney J. Ketner, Julian B. Lo, James A. S. Nightingale, Ravi M. Shanker, James B. West
-
Patent number: 8703171Abstract: The present invention relates to a method of easing childbirth using a composition having a lubricant effect for use in particular during human vaginal delivery. The methods comprise applying a bioadhesive composition comprising (a) a polyacrylic acid, (b) a water-soluble thickener and (c) a humectant and (d) optionally water.Type: GrantFiled: November 10, 2005Date of Patent: April 22, 2014Assignee: HCB Happy Child Birth Holding AGInventor: Andreas F. Schaub
-
Patent number: 8703195Abstract: Disclosed is a method in which poloxamer, a resin, and/or a tocopherol is/are fused, and the material that is to be treated is intimately dispersed with said melt. After being introduced into the melt, the material that is to be treated is coated with water to prevent hardening, and the spontaneously forming gel is homogenized. The obtained product is composed of a transparent gel that is based on at least one poloxamer, a resin or a tocopherol, and an active substance which is solubilized, dispersed, and stabilized therein and whose consistency ranges from solid, semisolid, i.e. aspic-like, to liquid. The micelles of said solubilized matter remain stable even when the same is diluted well below the CMC of poloxamer.Type: GrantFiled: March 9, 2007Date of Patent: April 22, 2014Assignee: Biorem AGInventor: Hanspeter Strobel
-
Patent number: 8697746Abstract: A solid dispersion comprising ((1S)-1-((((1S)-1-benzyl-2,3-dioxo-3-(cyclopropylamino)propyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester made amorphous in the presence of a water-soluble cellulosic polymer has improved storage stability. The solid dispersion also has improved solubility for an improved bioavailability.Type: GrantFiled: July 13, 2011Date of Patent: April 15, 2014Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Andrew Xian Chen, John Fan, Masazumi Yamaguchi
-
Patent number: 8697112Abstract: A method for treating a surface with a therapeutic agent is disclosed. The method comprises precipitating a therapeutic agent from a hydrophilic polymeric base layer with which the therapeutic agent has been complexed, to form a layer comprising microparticles of the therapeutic agent on the hydrophilic polymeric base layer, the hydrophilic polymeric base layer being grafted to the surface. Devices comprising a surface having a hydrophilic polymeric base layer comprising a hydrophilic polymer grafted to the surface and a layer comprising microparticles of a therapeutic agent disposed on and complexed with the hydrophilic polymeric base layer are also disclosed.Type: GrantFiled: July 6, 2012Date of Patent: April 15, 2014Assignee: Covalon TechnologiesInventors: Vyacheslav Dudnyk, Valerio DiTizio
-
Patent number: 8697105Abstract: The invention provides an injectable formulation that includes an active agent; a biocompatible solvent system, crosslinkable polymers such as polysaccharides; and crosslinking agents; wherein the formulation is substantially free of water. The invention also provides a drug delivery depot formed from the injectable formulation wherein the polymers crosslink in the presence of water in the body of a patient, or in the air, prior to implantation in the patient. Also provided are methods of treatment using such formulations and drug delivery systems.Type: GrantFiled: March 29, 2011Date of Patent: April 15, 2014Assignee: SurModics, Inc.Inventor: Joram Slager
-
Patent number: 8697127Abstract: The present invention relates to a method for preparing microspheres and microspheres prepared thereby, more particularly to a method for preparing a polymeric microsphere, including preparing an emulsion including a polymer compound, a drug, a water-insoluble organic solvent and a dispersion solvent and adding to the prepared emulsion a base or an acid to remove the water-insoluble organic solvent from the emulsion, a polymeric microsphere prepared thereby, and a composition for drug delivery including the microsphere. According to the present invention, a drug-containing polymer microsphere may be prepared quickly and simply without the solvent evaporation or solvent extraction process, thereby reducing water consumption and minimizing wastewater generation.Type: GrantFiled: May 12, 2011Date of Patent: April 15, 2014Assignees: Ewha University-Industry Collaboration Foundation, SK Chemicals Co., Ltd.Inventor: Hong Kee Sah
-
Patent number: 8696760Abstract: Biocompatible synthetic or natural scaffolds are provided for the reconstruction, repair, augmentation or replacement of organs or tissue structures in a patient in need of such treatment. The scaffolds are shaped to conform to at least a part of the organ or tissue structure and may be seeded with one or more cell populations. Inserts, receptacles and ports are also provided for the attachment of tubular vessels to the neo-organ scaffolds. The seeded scaffolds are implanted into the patient at the site in need of treatment to form an organized organ or tissue structure. The scaffolds may be used to form organs or tissues, such as bladders, urethras, valves, and blood vessels.Type: GrantFiled: March 1, 2011Date of Patent: April 15, 2014Assignee: Tengion, Inc.Inventors: Timothy A. Bertram, Andrew Bruce, Deepak Jain, Manuel J. Jayo, John W. Ludlow, Darell McCoy, Richard Payne, Namrata D. Sangha, Oluwatoyin A. Knight
-
Publication number: 20140099370Abstract: The present invention relates to biodegradable polymers (e.g., polyesters and polyester amides) derived from functionalized biologically active compounds that can provide site specific delivery of bioactive compounds upon biodegradation in a controlled manner.Type: ApplicationFiled: September 24, 2013Publication date: April 10, 2014Applicant: BEZWADA BIOMEDICAL, LLCInventor: Rao S Bezwada
-
Patent number: 8691278Abstract: Provided are bioerodible compositions that can be implanted into cavities or mammalian tissue as a liquid or semi-liquid and which solidify upon exposure of the body temperature of the mammal. The implants erode over a prescribed period of time and elute a drug. The implants also form a seal with the skin or mucosa surrounding the cavity to prevent the entry of bacterial pathogens.Type: GrantFiled: July 12, 2013Date of Patent: April 8, 2014Assignee: Trilogic Pharma LLCInventors: Hemant H. Alur, James A. H. Harwick, Pravakar Mondal, Thomas P. Johnston
-
Patent number: 8691203Abstract: The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers.Type: GrantFiled: March 23, 2012Date of Patent: April 8, 2014Assignee: Massachusetts Institute of TechnologyInventors: Christopher J. Bettinger, Joost P. Bruggeman, Lino Da Silva Ferreira, Jeffrey M. Karp, Robert S. Langer, Christiaan Nijst, Andreas Zumbuehl, Jason Burdick, Sonia J. Kim
-
Patent number: 8691878Abstract: A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-soluble polymer and at least one pharmaceutically acceptable surfactant, said pharmaceutically acceptable water-soluble polymer having a Tg of at least about 50° C. Preferably, the pharmaceutically acceptable surfactant has an HLB value of from about 4 to about 10.Type: GrantFiled: November 12, 2012Date of Patent: April 8, 2014Assignee: AbbVie Inc.Inventors: Jeorg Rosenberg, Ulrich Reinhold, Bernd Liepold, Gunther Berndl, Joerg Breitenbach, Laman Alani, Soumojeet Ghosh
-
Publication number: 20140093569Abstract: A pharmaceutical composition for controlled release of an active substance is provided. The active substance is released into an aqueous medium by erosion of at least one surface of the composition. The composition comprises i) a matrix comprising a) polymer or a mixture of polymers, b) an active substance and, optionally, c) one or more pharmaceutically acceptable excipients, and ii) a coating.Type: ApplicationFiled: August 23, 2013Publication date: April 3, 2014Applicant: EGALET LTD.Inventors: Gina Fischer, Daniel Bar-Shalom, Lillian Slot, Christine Andersen
-
Patent number: 8679523Abstract: The present invention comprises methods and compositions for delivery devices. More particularly, the present invention comprises methods and compositions for devices comprising a matrix comprising a polymer network and a non-gellable polysaccharide having oxygen and optionally active agents incorporated therein. The matrix may be formed into any desired shape for treatment of compromised tissue or for delivery of oxygen to a localized environment.Type: GrantFiled: December 29, 2000Date of Patent: March 25, 2014Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Bruce L. Gibbins, Lance D. Hopman