Containing Natural Gums/resins Patents (Class 424/496)
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Patent number: 11752078Abstract: The invention relates to oil-in-water emulsions containing 4-hydroxyacetophenone and anionic emulsifiers.Type: GrantFiled: January 27, 2015Date of Patent: September 12, 2023Assignee: Symrise AGInventors: Julia Pruns, Thomas Raschke, Bente Nissen
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Patent number: 11253629Abstract: A bone gel composition consists of cortical bone. The cortical bone is made from cut pieces freeze-dried then ground into particles and demineralized then freeze-dried. A volume of the particles is placed in a solution of sterile water to create a mixture, the water volume being at least twice the particle volume, the mixture is autoclaved under heat and pressure to form a gelatin, the resulting bone gel is formed into sheets having a thickness (t).Type: GrantFiled: August 15, 2016Date of Patent: February 22, 2022Assignee: Vivex Biologics Group, Inc.Inventors: Wendy W. Weston, Silvia Daniela Gonzales, Edgar S. Maldonado
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Patent number: 9782358Abstract: Provided is a monodisperse agglomerate of a substance-containing vesicle filled with a substance at a concentration higher than conventionally possible. A mixed solution, in which a target substance is included in an aqueous medium, is mixed with a monodisperse agglomerate of a crosslinked vesicle comprising a prescribed polymer which includes a first polymer, i.e. a block copolymer having uncharged hydrophilic segments and first charged segments, and a second polymer having second charged segments carrying a charge opposite to that of the first charged segments, and in which the first polymer and/or the second polymer are/is crosslinked. As a result, the crosslinked vesicle is made to contain the target substance.Type: GrantFiled: August 28, 2015Date of Patent: October 10, 2017Assignee: Japan Science And Technology AgencyInventors: Kazunori Kataoka, Akihiro Kishimura, Yasutaka Anraku, Akinori Goto
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Patent number: 9028882Abstract: A nutriceutical food product includes a solid polymeric matrix and a liquid combined into a gel. The nutriceutical food product may include an immune modulator, such as transfer factor and/or a nanofraction immune modulator. A fruit component may be included in the nutriceutical food product. The fruit component may include at least one oligoproanthocyanidin-containing fruit, such as açai.Type: GrantFiled: May 5, 2009Date of Patent: May 12, 2015Assignee: 4Life Patents, LLCInventors: Brent M. Vaughan, Calvin W. McCausland, David A. Lisonbee
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Publication number: 20150125391Abstract: Bone- and metal-targeted polymeric nanoparticles are provided. Exemplary nanoparticles have three main components: 1) a targeting element that can selectively bind to bone, minerals, or metal ions; 2) a layer of stealth to allow the polymer to evade immune response; and 3) a biodegradable polymeric material, forming an inner core which can carry therapeutics or other diagnostics. Preferred nanoparticles contain a blend of target-element polymer conjugate and polymer that optimizes the ligand density on the surface of the nanoparticle to provide improved targeting of the nanoparticle. The ratio of target-element polymer conjugate to polymer can also be optimized to improve the half-life of the nanoparticles in the blood of the subject. The nanoparticles also exhibit prolonged, sustained release of therapeutic agents loaded into the particles.Type: ApplicationFiled: November 3, 2014Publication date: May 7, 2015Inventors: Archana Swami, Pamela Basto, Jeffrey Karp, Omid C. Farokhzad
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Publication number: 20150110884Abstract: The present invention is an anhydrous cosmetic composition for making up and/or caring for the skin and/or lips, which is liquid at 20° C., comprising, in a physiologically acceptable medium, at least one fatty phase comprising:—at least one organopolysiloxane elastomer powder coated with silicone resin,—at least one organopolysiloxane elastomer conveyed in a first oil,—at least one wax, and—at least one second oil,—the said organopolysiloxane elastomer and the organopolysiloxane elastomer powder coated with a silicone resin being present in a ratio by weight on a dry basis of organopolysiloxane elastomer conveyed in an oil/organopolysiloxane elastomer powder coated with a silicone resin of greater than 2 and preferably of greater than 2.5.Type: ApplicationFiled: June 6, 2012Publication date: April 23, 2015Applicant: L'OREALInventors: Stephane Arditty, Veronique Jacques
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Patent number: 8975271Abstract: A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and a sufficient amount of a controlled release material to render the dosage form suitable for twice-a-day administration to a human patient, the dosage form providing a C12/Cmax ratio of 0.55 to 0.85, said dosage form providing a therapeutic effect for at least about 12 hours.Type: GrantFiled: December 3, 2013Date of Patent: March 10, 2015Assignee: Purdue Pharma L.P.Inventors: Benjamin Oshlack, Hua-Pin Huang, John Masselink, Alfred P. Tonelli
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Patent number: 8968872Abstract: Microcapsules comprising an agglomeration of primary microcapsules, each individual primary microcapsule having a primary shell and the agglomeration being encapsulated by an outer shell, may be prepared by providing an aqueous mixture of a loading substance and a shell material, adjusting pH, temperature, concentration and/or mixing speed to form primary shells of shell material around the loading substance and cooling the aqueous mixture until the primary shells agglomerate and an outer shell of shell material forms around the agglomeration. Such microcapsules are useful for storing a substance and for delivering the substance to a desired environment.Type: GrantFiled: April 27, 2010Date of Patent: March 3, 2015Assignee: DSM Nutritional Products AGInventor: Nianxi Yan
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Patent number: 8940675Abstract: The present disclosure includes cleansing compositions for removing soils from surfaces. Tee cleansing composition may be loaded ones a substrate to form a wet wipe. The cleansing composition may include a glucomannan and a synergy enhancing agent. The synergy enhancing agent may include xanthan gum. The synergy enhancing component may include xanthan gum and carrageenan. The wet wipe may be used to assist in the removal of soils such as feces, menses, and urine from skin.Type: GrantFiled: January 24, 2014Date of Patent: January 27, 2015Assignee: The Procter & Gamble CompanyInventors: Randall Glenn Marsh, Jacqueline Marie Duderstadt
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Patent number: 8932634Abstract: This invention discloses carrier beads comprising a hydrocolloid polymer comprising at least one inert filler material, wherein the at least one filler material provides improved properties including increased mechanical strength and/or reduced porosity relative to a bead without said at least one filler. The beads are useful per se or for delivery of active agents. Methods for preparation of the beads and the uses thereof are described particularly for controlling the rate of release an active agent from said bead.Type: GrantFiled: June 17, 2007Date of Patent: January 13, 2015Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem LtdInventors: Amos Nussinovich, Avi Gal
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Patent number: 8920846Abstract: A microcapsule in which a liquid droplet is coated with a resin, wherein in the droplet, a pesticidally active solid ingredient is suspended in a compound of formula (I), wherein R represents a C1-C5 alkyl group, is useful as a formulation of a pesticidally active solid ingredient.Type: GrantFiled: September 2, 2010Date of Patent: December 30, 2014Assignee: Sumitomo Chemical Company, LimitedInventors: Naoki Tsuda, Mayuko Ozawa
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Publication number: 20140349850Abstract: The present invention relates to coated dehydrated microorganisms comprising a dehydrated microorganism surrounded by at least one coating, said coating comprising by dry weight at least 25% of hygroscopic salt(s) and wherein the pH of the coating is compatible with viability of the coated dehydrated microorganism. The coating can be partially crystalline, the salt(s) in the coating having preferably a crystallinity degree of up to 60% once applied onto the dehydrated microorganism. The present invention also relates to liquid coating compositions, methods for coating and protecting a dehydrated microorganism. Finally, the present invention relates to a method for the preparation of food products, feed products, consumer healthcare products or agri-products as well as to a food product, feed product, a consumer healthcare product or an agri-product containing such coated dehydrated microorganisms.Type: ApplicationFiled: August 13, 2014Publication date: November 27, 2014Inventors: Isabelle Mazeaud, Kathryn Tse, Jean-Philippe Obert, Claudette Berger, Geoffrey Babin, Patrick Chaigneau, Hans Hedegaard Jensen, Erwan Henri
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Patent number: 8865219Abstract: The invention concerns coated granules including (A) at least one amine-containing pharmacological active principle, preferably as an acid addition salt, the pharmacological active principle being complexed by low cation-exchange resin containing carboxylic acid groups (COO?), and (B) at least 15 wt. %, based on the total weight of the active principle/low cation-exchange resin complex, of at least one hydrophilic adsorbent, the mixture of the components (A) and (B) being coated with a gastrosoluble polymer. The invention also concerns a method for preparing such granules, as well as orodispesible tablets containing such granules.Type: GrantFiled: September 25, 2006Date of Patent: October 21, 2014Assignee: EthypharmInventors: Mahendra B. Chaudhari, Edouard Gendrot
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Patent number: 8846092Abstract: Described are pharmacological compositions comprising a gum resin; a pharmacologically active agent and a topically acceptable volatile solvent for the gum resin and active agent. Also described are methods for the transdermal or transmucosal delivery of a pharmacologically active agent using such compositions.Type: GrantFiled: May 4, 2012Date of Patent: September 30, 2014Assignee: Jaleva Pharmaceuticals, LLCInventors: Alex Battaglia, Eva Beim
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Patent number: 8820331Abstract: A smoking device includes a recipient or able to receive burning (i.e., burnable) products, preferably tobacco, and a filter element connected to the recipient, wherein the filter includes at least one breakable capsule, the capsule having a initial crush strength from 0.5 to 2.5 kp, and keeping a crush strength from 0.5 to 2.5 kp and a deformation of less than two third of its diameter prior to rupture after having been submitted to a smoking test. The invention is also relating to the capsule suitable for being incorporated in a smoking device, and to the process of manufacture of the capsule.Type: GrantFiled: June 21, 2006Date of Patent: September 2, 2014Assignee: V. Mane FilsInventors: Didier Hartmann, Jean-Michel Hannetel, Nathalie Coursieres, Jean Mane
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Publication number: 20140220148Abstract: The present invention relates to pharmaceutical compositions, food supplement compositions and cosmetic compositions comprising diaminooxidase, and to the use thereof.Type: ApplicationFiled: April 4, 2014Publication date: August 7, 2014Applicant: SCIOTEC DIAGNOSTIC TECHNOLOGIES GMBHInventors: Albert MISSBICHLER, Franz GABOR, Herwig REICHL
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Patent number: 8753685Abstract: The invention provides stabilized, biocompatible gold nanoparticles that are stabilized with material from polyphenols- or flavanoids-rich plant material or reactive phytochemical components of the plant material. The gold nanoparticles of the invention can be fabricated with an environmentally friendly method for making biocompatible stabilized gold nanoparticles. In preferred embodiments, the coating consists of material from polyphenols- or flavanoids-rich plant material or reactive phytochemical components of the plant material.Type: GrantFiled: November 19, 2012Date of Patent: June 17, 2014Assignee: The Curators of the University of MissouriInventors: Kattesh V. Katti, Raghuraman Kannan, Kavita K. Katti, Satish Kumar Nune
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Publication number: 20140154328Abstract: The invention relates to an oral pharmaceutical composition comprising coated particles of a complex of at least one active agent with an ion-exchange resin, wherein said particles are coated with a bioadhesive coating layer comprising at least one bioadhesive material. The invention also relates to a process for preparing the oral pharmaceutical composition.Type: ApplicationFiled: April 5, 2012Publication date: June 5, 2014Inventor: Cvjetko Brkicic
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Patent number: 8715739Abstract: Methods for preparing uniformly sized micropanicles, with an optional polymeric coating generally include: 1) providing nanoparticles, preferably having a size of between 1 nm and 100 nm; 2) adding a hydrophobic surface layer to the nanoparticles; 3) making a suspension of the hydrophobic nanoparticles and a polymerization initiator in an hydrophobic solvent; 4) dissolving a monomer in the hydrophobic solvent; 5) making an emulsion by dispersing droplets of the hydrophobic solvent in a continuous aqueous phase with an emulsifier; 6) sizing the first emulsion to provide a second emulsion of the same components in which the droplets are substantially uniform and between 2 and 20 um in size; 7) evaporating at least a substantial portion of the dispersed hydrophobic droplets to assemble nanoparticles to form micropanicles suspended now in the aqueous phase; 8) replacing the first surfactant with a second surfactant, which is preferably a polymerizable surfactant; 9) adding a polymerizable monomer to the aqueous pType: GrantFiled: October 24, 2006Date of Patent: May 6, 2014Assignee: Purdue Research FoundationInventors: Gil U. Lee, Hao Shang, Won-Suk Chang
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Publication number: 20140112981Abstract: A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and a sufficient amount of a controlled release material to render the dosage form suitable for twice-a-day administration to a human patient, the dosage form providing a C12/Cmax ratio of 0.55 to 0.85, said dosage form providing a therapeutic effect for at least about 12 hours.Type: ApplicationFiled: December 3, 2013Publication date: April 24, 2014Applicant: Purdue Pharma L.P.Inventors: Benjamin Oshlack, Hua-Pin Huang, John Masselink, Alfred P. Tonelli
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Patent number: 8685425Abstract: Microcapsules possessing Lewis acid-Lewis base salt walls incorporate water-immiscible materials, such as N,N-di-ethyl-m-toluamide (DEET), as a core component. Such microcapsules, or similar microcapsules incorporating other core components, may be made by emulsifying a water-immiscible core component in an aqueous solution of one wall-forming reactant, such as the Lewis base, and then mixing that solution with the other wall-forming reactant, such as the Lewis acid. Various adjuvants may be included with the core component to contribute additional characteristics, such as enhancement of a controlled release characteristic or improved mechanical stability.Type: GrantFiled: October 17, 2011Date of Patent: April 1, 2014Inventor: Tycho J. Speaker
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Publication number: 20140044793Abstract: A composition comprising a core material, having a taste value and a polymeric coating. The polymeric coating substantially surrounds the core material and comprises a cationic polymer and optionally an anionic polymer. The polymeric coating has a uniform thickness ranging from 2 ?m to 20 ?m. The composition provides release of a portion of the core material which is taste masked over a time period ranging from 0.5 minute to 2 minutes in the oral cavity and provides a modified-release of the remaining core material in a gastrointestinal tract.Type: ApplicationFiled: September 20, 2011Publication date: February 13, 2014Applicant: SPI PHARMA, INC.Inventors: Diane Goll, Cecil W. Propst
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Publication number: 20140037744Abstract: Disclosed is a microcapsule including a core having an oxidizable active (OA), the outer part of said core being in a solid form, and a water insoluble coating obtained from an encapsulating agent (EA), with the coating surrounding said core. In particular, there is disclosed a microcapsule wherein the EA is water soluble or organic solvent, in particular ethanol, soluble, or a microcapsule wherein said EA is an agent, the water solubility of which is pH-dependent. In particular, the core does not consist in or comprise a metal oxide, and the coating does not comprise a disintegrant, in particular sodium starch glycolate. Also disclosed is a process for preparing the microcapsules.Type: ApplicationFiled: October 16, 2013Publication date: February 6, 2014Applicant: IDCAPSInventors: Pierre BUISSON, Carine CHAIGNEAU, Jean-Eudes VENDEVILLE
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Patent number: 8637440Abstract: A personal cleansing composition includes a surfactant, a thickener, emulsifier and at least one particulate dispersed in the thickener, the at least one particulate being formed of a substantially biodegradable substance. The at least one particulare may include a soy meal based polymer. The soy meal based polymer is both stable and biodegradable. The at least one particulate includes a group of suspended particles added to mechanically scrub the skin of a user or used as a textural ingredient to modify the feel, spreadability or slip of a product. The soy meal based polymer is useful in personal cleansing compositions as an exfoliant, a scrub, a film former or as a filler. The half-life of the composition may be modified as necessary based on the shelf-life of the product.Type: GrantFiled: November 6, 2012Date of Patent: January 28, 2014Inventor: Kim Cervino
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Patent number: 8623386Abstract: The present invention provides compositions for natural cosmetic products and, more particularly, to natural ester, wax or oil treated pigments, the products of such treated pigments and cosmetic products incorporating pigments treated with natural ingredients.Type: GrantFiled: April 8, 2009Date of Patent: January 7, 2014Assignee: Kobo Products, Inc.Inventors: David Schlossman, Yun Shao
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Publication number: 20130309313Abstract: Disclosed are compositions including powdered green tea extract and a powdered preparation comprising polyunsaturated fatty acids. Also disclosed are methods of preparing the compositions and using the compositions in food products, as well as food products containing or that are prepared from the compositions.Type: ApplicationFiled: May 21, 2012Publication date: November 21, 2013Applicant: OCEAN NUTRITION CANADA LIMITEDInventors: Amber Lynn Gareau, Sharon Ann Spurvey Pittman, Lariza Beristain Taboada
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Patent number: 8586094Abstract: Disclosed is a pharmaceutically acceptable oral dosage form comprising fenofibrate, phospholipid, a buffer salt, a water-soluble bulking agent selected from maltodextrin, mannitol, and combinations thereof, a cellulosic additive, beads or crystals of a pharmaceutically acceptable water-soluble excipient support material, a polyvinylpyrrolidone or crospovidone, croscarmellose sodium, granular mannitol, sodium dodecyl sulfate, silicon dioxide, and a stearate, wherein the fenofibrate is in the form of microparticles, and wherein at least a portion of the phospholipid is coated on the surfaces of the fenofibrate microparticles, the phospholipid coated microparticles are embedded in a matrix comprising the water-soluble bulking agent, phospholipid that is not coated on the microparticles, the buffer salt and the cellulosic additive, and the matrix is coated on up to 100% of the surfaces of the beads or crystals of the excipient support material.Type: GrantFiled: May 2, 2003Date of Patent: November 19, 2013Assignee: Jagotec AGInventors: Michael Vachon, Mishra K. Awadesh, Robert A. Snow, Pol-Henri Guivarc'H
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Patent number: 8551526Abstract: A method for preparing poorly water soluble drug particles is disclosed. The method comprises dissolving a drug in at least one organic solvent to form a drug/organic mixture, spraying the drug/organic mixture into an aqueous solution and concurrently evaporating the organic solvent in the presence of the aqueous solution to form an aqueous dispersion of the drug particles. The resulting drug particles are in the nanometer to micrometer size range and show enhanced dissolution rates and reduced crystallinity when compared to the unprocessed drug. The present invention additionally contemplates products and processes for new drug formulations of insoluble drug particles having high dissolution rates and extremely high drug-to-excipient ratios.Type: GrantFiled: October 8, 2002Date of Patent: October 8, 2013Assignee: Board of Regents, The University of Texas SystemInventors: Keith P. Johnston, Robert O. Williams, III, Xiaoxia Chen
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Patent number: 8529955Abstract: A method of treatment for epilepsy and other disease states is described, which comprises delivery of gabapentin in a gastric retained dosage form.Type: GrantFiled: November 21, 2011Date of Patent: September 10, 2013Assignee: Depomed, Inc.Inventors: Bret Berner, Sui Yuen Eddie Hou, Gloria M. Gusler
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Publication number: 20130216617Abstract: The present invention relates to stable pharmaceutical compositions of (R)-lansoprazole or pharmaceutically acceptable salts thereof and process of preparing the same. The invention particularly provides pharmaceutical compositions of optically active (R)-isomer of lansoprazole with at least two functional coating layers.Type: ApplicationFiled: June 28, 2011Publication date: August 22, 2013Applicant: CADILA HEALTHCARE LIMITEDInventors: Sunilendu Bhushan Roy, Sushrut Krishnaji Kulkarni, Manohar Vishwanath Lalge, Vaibhav Panditrao Deshmukh
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Publication number: 20130202711Abstract: Provided is a method for easily and efficiently producing encapsulated substance vesicles wherein a substance is encapsulated in the cavity of vesicles obtained by polymer self-assembly. Empty vesicles that have membranes comprising a first polymer that is a block copolymer with uncharged hydrophilic segments and a first kind of charged segments and a second polymer with a second kind of charged segments that carry a charge that is the opposite of said first kind of charged segments as well as spaces that are enclosed by said membranes are mixed in an aqueous medium with the substance that is to be encapsulated in the spaces.Type: ApplicationFiled: May 23, 2011Publication date: August 8, 2013Applicant: Japan Science and Technology AgencyInventors: Kazunori Kataoka, Akihiro Kishimura, Yasutaka Anraku, Kanjiro Miyata, Sayan Chuanoi, Tomoya Suma, Makoto Oba
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Patent number: 8501236Abstract: A method for producing a tableting additive, which method comprises providing a spray dried tableting additive in particulate form which particles at leas partially consist of amorphous additive material and at least partially of crystalline additive material; and crystallising the amorphous additive material by subjecting the particles for a short time and under agitation to a temperature between 30 and 100° C. at a relative humidity between 60 and 25%. More in particular, the relationship between relative humidity and temperature is defined by the formula: % relative humidity=218-47*Ln(T(° C.)), wherein T(° C.) is the temperature to which the particles are subjected.Type: GrantFiled: February 29, 2012Date of Patent: August 6, 2013Assignee: Campina B.V.Inventors: Klaas Daniel Kussendrager, Henricus Alphonsus Maria Van Den Biggelaar
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Publication number: 20130177652Abstract: The invention relates to pharmaceutical oral dosage forms of the active substance ethyl 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazole-5-carbonyl)-pyridin-2-yl-amino]-propionate (dabigatran etexilate) and the pharmacologically acceptable salts thereof, in particular dabigatran etexilate methanesulfonate.Type: ApplicationFiled: July 1, 2011Publication date: July 11, 2013Applicant: KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTOInventor: Vesna Kroselj
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Patent number: 8465776Abstract: The present invention relates to granules comprising oxycodone, as well as to orally disintegrating tablets including same and optionally acetaminophen.Type: GrantFiled: July 31, 2007Date of Patent: June 18, 2013Assignee: EthypharmInventor: Didier Hoarau
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Publication number: 20130129618Abstract: The invention provides stabilized, biocompatible gold nanoparticles that are stabilized with material from epigallocatechin Gallate (EGCg), which is a polyphenols- or flavanoids-rich plant material that can be obtained from green tea. The EGCg is an an antioxidant reducing agent derived from green tea. The gold nanoparticles of the invention can be radioactive or non radioactive and are formed via a simple room temperature fabrication method. In preferred embodiment method of making, an aqueous solution containing gold salts is provided. The aqueous solution is mixed with EGCg in a buffer, such as deionized water. The gold salts react to form biocompatible gold nanoparticles that are stabilized with a coating of EGCg. The thermodynamically feasible redox couple of AuCl4-EGCg leading to the reduction of AuCl4- by EGCg to form gold nanoparticles. In another embodiment, pre-cooled gold salt and EGCg solutions form multi-layered EGCg coated particles.Type: ApplicationFiled: November 5, 2012Publication date: May 23, 2013Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURIInventor: THE CURATORS OF THE UNIVERSITY OF MISS
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Patent number: 8409620Abstract: A method of controlling moss by applying to grass infested with moss a dry composition including: a) a source of nitrogen such as isobutylenediurea or methylene urea; b) a non-ionic surfactant or wetting agent; c) a metal containing salt, and d) an acidic pH adjusting agent effective to adjust the pH of the composition to a pH of between 2.5 and 5 when wetted on grass. The dry composition may be a granular composition, and may be applied by broadcasting over a large area.Type: GrantFiled: August 14, 2012Date of Patent: April 2, 2013Inventor: David W. Livingston
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Publication number: 20120315336Abstract: Described are injectable formulations of particulate olanzapine that produce a prolonged duration of action upon administration, and methods of making and using such formulations. The injectable formulations comprise particulate olanzapine.Type: ApplicationFiled: May 3, 2012Publication date: December 13, 2012Applicant: Alkermes Pharma Ireland LimitedInventors: Stephen B. Ruddy, David Czekai, Gary Liversidge, Scott A. Jenkins, Elaine M. Liversidge
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Patent number: 8329628Abstract: A personal cleansing composition includes a surfactant, a thickener, emulsifier and at least one particulate dispersed in the thickener, the at least one particulate being formed of a substantially biodegradable substance. The at least one particular may include a soy meal based polymer. The soy meal based polymer is both stable and biodegradable. The at least one particulate includes a group of suspended particles added to mechanically scrub the skin of a user or used as a textural ingredient to modify the feel, spreadability or slip of a product. The soy meal based polymer is useful in personal cleansing compositions as an exfoliant, a scrub, a film former or as a filler. The half-life of the composition may be modified as necessary based on the shelf-life of the product.Type: GrantFiled: May 10, 2011Date of Patent: December 11, 2012Inventor: Kim Cervino
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Patent number: 8303741Abstract: A process for producing an oral preparation containing a first water-swellable gel-forming layer and a second water-swellable gel-forming layer as outermost layers, a medicine being sealed in an inner space formed by bonding the periphery of the first water-swellable gel-forming layer and the periphery of the second water-swellable gel-forming layer either directly or via an adhesive layer, the process including (a) a step of forming a first water-swellable gel-forming layer, (b) a step of forming a recess in a predetermined area of the first water-swellable gel-forming layer, (c) a step of filling the recess with a medicine to obtain a medicine-containing body, and (d) a step of forming a second water-swellable gel-forming layer over the medicine-containing body directly or via an adhesive layer so that the first water-swellable gel-forming layer and the second water-swellable gel-forming layer are bonded around the recess, and a process for continuously producing the oral preparation are disclosed.Type: GrantFiled: December 14, 2007Date of Patent: November 6, 2012Assignee: Lintec CorporationInventors: Akio Kabuto, Yusaku Sugiura, Eiji Suzuki, Hideaki Okabe
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Patent number: 8282961Abstract: The present invention provides a preparing method of microcapsule containing unsaturated fatty acid comprising the steps of (a) preparing a first coating material by mixing and gelatinating one or more gums selected from the group consisting of xanthan gum, guar gum, and locusbean gum, with poly glycerin esters of fatty acid in sterilized water, adding unsaturated fatty acid to the solution, and homogenizing the solution; (b) preparing a second coating material by mixing and gelatinating starch or modified starch, gelatin or casein, and poly glycerin esters of fatty acid in sterilized water, adding the first coating material prepared in (a) to the solution, and homogenizing the solution; and (c) spraying the second coating material prepared in (b) in cold sterilized water; a microcapsule prepared by the method; and articles containing the microcapsule. The present microcapsule has effects of preventing the oxidation of unsaturated fatty acid and inhibiting offensive smell.Type: GrantFiled: July 27, 2007Date of Patent: October 9, 2012Assignee: Chebigen Inc.Inventors: Hong-Sig Sin, Si-Ho Park, Soo-Jong Um, Jong-Hyun Lee, Hee-Jeong Kim, Ha-Lyong Jin, Hyoung-Su Kim
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Publication number: 20120207843Abstract: A floating granule having a solid core, on which an active ingredient is supported, and a compound capable of generating a gas discharge which is constituted by an alkaline agent, characterised in that it does not comprise an acid agent that is capable of generating a gas discharge.Type: ApplicationFiled: August 11, 2010Publication date: August 16, 2012Applicant: DEBREGEAS ET ASSOCIES PHARMAInventors: Christophe P. Lebon, Pascal J. Suplie
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Patent number: 8216598Abstract: The present invention deals with an alternative interfacial polymerization process of microencapsulation, microcapsule's produced thereof, microencapsulated agrochemicals, pharmaceuticals, catalysts and phase transfer materials, and formulations thereof, by means of microcapsules and starting materials with much lower toxicological profile than customary microencapsulation materials, and with the participation of acetylene carbamide derivatives in the final structure of the microcapsules' wall.Type: GrantFiled: March 28, 2007Date of Patent: July 10, 2012Assignee: GAT Microencapsulation AGInventors: Victor Casaña Giner, Miguel Gimeno Sierra, Barbara Gimeno Sierra
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Publication number: 20120171297Abstract: The present invention relates to pharmaceutical formulations for the controlled delivery of threo-3-(3,4-dihydroxyphenyl)serine (threo-DOPS) and derivatives of it. Such formulations can contain an extended or slow release component that maintains therapeutic concentration of threo-DOPS in the blood plasma over a prolonged time period. They can be further combined with an immediate release formulation to produce a product that, when administered to a patient in need thereof, results in substantially steady levels of active drug, eliminating the sharp peaks and troughs in blood plasma drug levels experienced with the existing threo-DOPS formulations.Type: ApplicationFiled: March 13, 2012Publication date: July 5, 2012Inventors: Stephen Peroutka, James Swarbrick
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Publication number: 20120164233Abstract: The present invention relates to a pulsatile-release pharmaceutical formulation of dexlansoprazole composed of a single type of enteric coated pellets and the process for the preparation thereof.Type: ApplicationFiled: July 28, 2011Publication date: June 28, 2012Applicant: RANBAXY LABORATORIES LIMITEDInventors: Ankur BHARGAVA, Sachin ARORA, Ajay Kumar SINGLA
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Patent number: 8206746Abstract: The invention provides a composition comprising microparticles of a water-insoluble or poorly soluble compound, at least one phospholipid, and at least one surfactant, produced by applying an energy to a mixture comprising particles of the compound, the at least one phospholipid, and the at least one surfactant so as to obtain the microparticles. The invention also provides a process for preparing microparticles of a water-insoluble or poorly soluble compound. The process includes mixing particles of a water-insoluble or poorly soluble compound with at least one phospholipid and at least surfactant to form a mixture and applying energy to the mixture sufficient to produce microparticles of the compound. The methods of the invention allow for the production of microparticles smaller than particles produced through previously known methods and the microparticles exhibit advantageous properties including remarkable resistance to particle size growth during storage.Type: GrantFiled: September 30, 2002Date of Patent: June 26, 2012Assignee: Jagotec AGInventors: Indu Parikh, Ulagaraj Selvaraj
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Publication number: 20120156303Abstract: A microcapsule in which a liquid droplet is coated with a resin, wherein in the droplet, a pesticidally active solid ingredient is suspended in a compound of formula (I), wherein R represents a C1-C5 alkyl group, is useful as a formulation of a pesticidally active solid ingredient.Type: ApplicationFiled: September 2, 2010Publication date: June 21, 2012Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Naoki Tsuda, Mayuko Ozawa
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Publication number: 20120128780Abstract: Nanoparticulate bisphosphonate compositions, having an effective average particle size of less than 2000 nm, are described. The compositions are useful in treating bone resorption in a mammal.Type: ApplicationFiled: October 17, 2011Publication date: May 24, 2012Inventors: Gary G. Liversidge, Scott Jenkins
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Patent number: 8168225Abstract: The invention relates to microcapsules, and a continuous micro-encapsulation water-in-oil-in-water microencapsulation process through in situ and interfacial polymerization of the emulsion. The formulation comprises a continuous water phase having a dispersion of microcapsules which contain oil drops and wherein the inside of each oil phase drop—containing optionally oil-soluble materials—there is a dispersion of water, or aqueous extract or water dispersible material or water soluble material. The oil drops are encapsulated with a polymerisable material of natural origin. Such microcapsules are appropriated for spray-dry processes, to be used as dry powder, lyophilized, self-emulsifiable powder, gel, cream and any liquid form. The active compounds included in the microcapsules are beneficial to the health and other biological purposes.Type: GrantFiled: December 17, 2004Date of Patent: May 1, 2012Assignee: GAT Formulation GmbHInventors: Victor Casaña Giner, Miguel Gimeno Sierra, Barbara Gimeno Sierra, Martha Moser
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Patent number: 8147874Abstract: Coated pellets which comprise an active pharmaceutical ingredient that is poorly soluble in water, release at least 80% of the active ingredient under in vitro conditions in phosphate buffer at pH 5.0 after 30 minutes and are bioequivalent to a liquid formulation of the active ingredient under in vitro fed status test conditions and/or are coated with a composition, which includes a lipophilic component (A) and a hydrogel former (B), wherein the pure lipophilic component (A) has (i) an HLB value of ?5, and/or (ii) a melting range of ?60° C., and/or (iii) a solidification range ? of less than 35° C., and/or (iv) a density of ?0.80 g cm?3.Type: GrantFiled: June 12, 2009Date of Patent: April 3, 2012Assignee: Gruenenthal GmbHInventors: Iris Ziegler, Irwin Jacobs
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Publication number: 20120076863Abstract: The present invention is directed to anti-hypertensive compositions comprising a nanoparticulate temocapril, or a salt or derivative thereof, having improved bioavailability. The nanoparticulate temocapril particles of the composition have an effective average particle size of less than about 2000 nm and are useful in the treatment of hypertension and related diseases.Type: ApplicationFiled: September 29, 2011Publication date: March 29, 2012Inventors: Scott Jenkins, Gary Liversidge