Digestive System (e.g., Salivary Gland, Etc.) Patents (Class 424/550)
Gastrointestinal system (e.g., intestine, stomach, gall bladder, etc.) (Class 424/551)
  • Factor Xa inibitor from leech and pharmaceutical compositions containing same
    Patent number: 5182113
    Abstract: A novel anticoagulant/modulator factor isolated from the saliva of the medicinal leech Hirudo medicinalis, specifically inhibiting bovine Xa factor but not inhibiting bovine thrombin.
    Type: Grant
    Filed: June 23, 1989
    Date of Patent: January 26, 1993
    Assignee: Bio-Technology General Corp.
    Inventors: Meir Rigbi, Craig M. Jackson
  • Isolation and structural elucidation of the cytostatic linear depsipeptides dolastatin 13 and dehydrodolastatin 13
    Patent number: 4986988
    Abstract: The Indian Ocean sea hare Dolabella auricularia has been found to contain a new cell growth inhibitory and antineoplastic (P388 leukemia) cyclodepsipeptide designated dolastatin 13.sup.(1) and a companion substance dehydrodolastatin 13.sup.(2). A series of high field (400 MHz) 2D-NMR experiments including sequential analyses by HMBC and NOE techniques and tandem mass spectrometry provided structural determinations. Dolastatin 13 and dehydrodolastatin 13 represent a new class of cyclodepsipeptides. Pharmaceutical preparations and therapeutic regimens employing these new cytostatic depsipeptides are disclosed.
    Type: Grant
    Filed: May 18, 1989
    Date of Patent: January 22, 1991
    Assignee: Arizona Board of Regents
    Inventors: George R. Pettit, Yoshiaki Kamano