Hydroxy Carboxylic Acid Or Derivative Thereof (e.g., Methyl Salicylate, Etc.) Patents (Class 424/55)
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Patent number: 5188822Abstract: Oral composition containing an oil-in-water emulsion, wherein the oil phase of the emulsion includes an aminoalkyl silicone and a lipophilic compound and the aqueous phase includes an emulsifier. The lipophilic compound is soluble in the aminoalkyl silicone. Preferably, a lipophilic antimicrobial agent or a lipophilic flavorant is employed. The aminoalkyl silicone forms a substantive film on the teeth surface and the lipophilic compound is deposited, along with the aminoalkyl silicone, on the teeth surface. Thus, the enhanced deposition of the lipophilic compound is attained. The pH of the compositions is preferably at least 7.0. The compositions are preferably applied by brushing.Type: GrantFiled: August 7, 1991Date of Patent: February 23, 1993Assignee: Chesebrough-Pond's USA Co., Division of Conopco Inc.Inventors: John P. Viccaro, John S. Bajor, Alla Tartakovsky
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Patent number: 5174990Abstract: A mouthrinse preparation having between about 0.25% and about 0.65% hydrogen peroxide, between about 0.005% and about 0.1% zinc chloride, at least about 0.012% sodium citrate, at least about 0.03% sodium lauryl sulfate, at least about 0.006% citric acid and between about 2% and about 3.5% ethanol, the mouthrinse preparation remaining stable upon continuous exposure to a temperature of 37.degree. C. at atmospheric pressure for at least 30 days. A method for preparation of same.Type: GrantFiled: September 5, 1991Date of Patent: December 29, 1992Assignee: 7-L CorporationInventor: Jerry A. Douglas
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Patent number: 5165913Abstract: The present invention discloses dental floss containing surfactant and silicone preparations with added chemotherapeutic agents.Type: GrantFiled: August 29, 1991Date of Patent: November 24, 1992Inventors: Ira Hill, Robert D. White
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Patent number: 5143720Abstract: Anhydrous sanitizing and disinfecting concentrate compositions having excellent shelf life and chemical stability comprise less than 0.1 weight percent water; an anionic surfactant present in an amount of from about 0.05 weight percent to about 10.0 weight percent, and an acidic component, present in an amount effective to produce a pH of below pH 5.0 upon dilution with water.Between about 0.25 parts by weight to about 7.5 parts by weight of the concentrate compositions are diluted with sufficient water to make 100 parts by weight of an aqueous solution having excellent antimicrobial activity against gram positive and gram negative bacteria.Type: GrantFiled: November 28, 1990Date of Patent: September 1, 1992Assignee: Microcide, Inc.Inventor: John A. Lopes
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Patent number: 5120460Abstract: A dental cleaner material comprises as a main component an aqueous solution containing 0.1 to 2.0% by weight of ethylenediaminetetraacetic acid or at least one of its alkali metal salts. The cleaner material is gelled by the addition of a carboxyvinyl polymer, carboxymethylcellulose or sodium carboxymethylcellulose as a raiser in viscosity showing thixotropy, further contains 0.01 to 0.3% by weight fo a p-hydroxybenzoic acid ester as an antibacterial agent, and is regulated to pH of 7.0.+-.0.5.Type: GrantFiled: March 29, 1990Date of Patent: June 9, 1992Assignees: G-C Dental Industrial Corp., Yasuhiro AsaiInventors: Yasuhiro Asai, Kiyoko Nakamura, Masayuki Takahashi
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Patent number: 5112600Abstract: An anti-caries composition has a source of hydrogen citrate ions, preferably an alkali metal hydrogen citrate salt, an oxalate salt and an orally acceptable excipient, and optionally further comprises an ionic fluorine-containing compound. The composition may be in the form of dentifrice when silica is the preferred abrasive, or a mouthwash.Type: GrantFiled: May 16, 1991Date of Patent: May 12, 1992Assignee: Beecham Group p.l.c.Inventors: Robert J. Jackson, Susan A. Duke, Paul Barnett
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Patent number: 5094842Abstract: The invention relates to oral compositions such as toothpastes which contain Vitamin C and a copper compound such as copper sulphate. The tendency of these compositons to discolor, particularly if they also contain a zinc compound such as zinc citrate, can be reduced by the inclusion in the compositions of a stannous compound such as stannous pyrophosphate.Type: GrantFiled: October 4, 1990Date of Patent: March 10, 1992Assignee: Chesebrough-Pond's USA Co., Division of Conopco, Inc.Inventor: Paul I. Riley
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Patent number: 5094845Abstract: Alkali metal zinc gluconate complexes used in oral compositions such as gingival and subgingival irrigating solutions, dentifrices, mouthwashes, and the like as well as in other preparations for treating oral lesions.Type: GrantFiled: March 4, 1991Date of Patent: March 10, 1992Assignees: David G. Vlock, Lawrence RosenInventor: Richard S. Vlock
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Patent number: 5093170Abstract: The present invention relates to compositions and methods for inhibiting plaque. In particular, this invention relates to oral compositions comprising: (a) a safe and effective amount of a carboxy-substituted polymer active agent having the formula ##STR1## or the salts thereof, wherein R is a C.sub.1 -C.sub.8 alkyl group, n is in the range of from 0 to about 2,000, m is in the range of from about 10 to about 2,000, and p is in the range of from about 1 to about 10; and (b) a pharmaceutically acceptable carrier. These compositions inhibit plaque without staining the tooth surfaces which are contacted with the composition.This invention also relates to a method of inhibiting plaque on tooth surfaces in the oral cavity. This method involves applying a safe and effective amount of the carboxy-substituted polymer active agent to the oral cavity. Such an application is typically made by applying the above-described oral compositions containing the carboxy-substituted polymer to the tooth surface.Type: GrantFiled: June 25, 1990Date of Patent: March 3, 1992Assignee: The Procter & Gamble Co.Inventors: Charles R. Degenhardt, Barbara A. Kozikowski
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Patent number: 5079288Abstract: Oral hygiene compositions effective for preventing the adherent deposition of cariogenic bacteria on teeth comprise as active constituents polymers having defined repeating units comprising hydrocarbyl groups with pendant carboxyl and pendant polyalkylene oxide groups in defined ratio. The polymers themselves, their prepartion, and a process for treating teeth with the compositions are also claimed.Type: GrantFiled: March 19, 1990Date of Patent: January 7, 1992Assignee: Imperial Chemical Industries PLCInventors: Martyn Humphries, Jozef Nemcek, Joseph F. Jaworzyn, John B. Cantwell, John J. Gerrard
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Patent number: 5071638Abstract: An oral composition containing (i) fumed silica and polyethylene glycol having an average molecular weight of 2000 to 6000.Type: GrantFiled: December 22, 1987Date of Patent: December 10, 1991Assignee: Lion CorporationInventors: Makoto Yoshie, Shinichi Seto, Fumito Takahashi
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Patent number: 5068100Abstract: Disclosed are oral compositions containing phosphocitrate to provide improved anticalculus activity.Type: GrantFiled: November 14, 1990Date of Patent: November 26, 1991Assignee: The Procter & Gamble CompanyInventor: Stephen F. McClanahan
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Patent number: 5064640Abstract: Improved anticariogenic oral preparations having a pH of about 2.5 to about 5.0 comprise an anticariogenically effective amount of a water-soluble aluminum salt in a surfactant-containing emulsion system suitable for use in the mouth.Type: GrantFiled: October 3, 1990Date of Patent: November 12, 1991Assignee: Purdue Research FoundationInventors: Carl J. Kleber, Mark S. Putt
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Patent number: 5059416Abstract: A new delivery system for zinc compounds and the process for its preparation is disclosed, which has use in a variety of products including comestibles such as chewing gum compositions, confections, pharmaceuticals, food products such as vitamin preparations, dentifrice compositions and throat lozenges. More particularly, this invention relates to a process for preparing a zinc compound delivery system comprised of a zinc core material coated with a first hydrophilic coating comprising a hydrocolloid material and a second hydrophobic coating selected from the group consisting of fats, waxes and mixtures thereof. The delivery system provides enhanced masking of the bitter flavor characteristic of zinc compounds, as well as reduced grittiness with retained stability at the elevated temperatures of product formulation.Type: GrantFiled: June 26, 1989Date of Patent: October 22, 1991Assignee: Warner-Lambert CompanyInventors: Subraman R. Cherukuri, Tommy L. Chau
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Patent number: 5055305Abstract: Denture cleansing tablet comprising an inorganic persalt bleaching agent, an organic peroxyacid bleach precursor and a solid base material which in the presence of water releases carbon dioxide with effervescence. The composition provides more rapid and efficaceous denture cleansing performance and anti-bacterial activity.Type: GrantFiled: December 2, 1988Date of Patent: October 8, 1991Assignee: Richardson-Vicks, Inc.Inventor: Kenneth Young
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Patent number: 5032385Abstract: An oral hygiene composition contains (a) from 0.01 to 2% by weight of Triclosan, (b) from 2 to 10% by weight of polyethylene glycol of molecular weight from 200 to 1000, and (c) 0.1 to 2% by weight of oil-based flavor material.The polyethylene glycol helps to maintain an effective level of orally available Triclosan.Type: GrantFiled: October 21, 1986Date of Patent: July 16, 1991Assignee: Beecham Group plcInventors: John V. Reed, Carol A. Jeffryes, Peter J. Edwards
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Patent number: 5032388Abstract: Tartar formation on teeth is prevented with compositions of a sodium salt ethylenediaminetetraacetic acid having a pH between about 5.5 and 9.0 in a carrier which permits application to the teeth. Aqueous solution may be used for this purpose as well as toothpaste compositions.Type: GrantFiled: September 19, 1988Date of Patent: July 16, 1991Assignees: Kaj Rainer Lilius, Matti Haakon August TikkanenInventor: Matti H. A. Tikkanen
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Patent number: 5028415Abstract: The present invention relates to oral compositions, such as dentifrices, toothpastes and mouthwashes, which provide an anticalculus benefit. These compositions comprise a safe and effective amount of an anticalculus agent which is a polyepoxysuccinic acid, or its pharmaceutically-acceptable salts, along with a pharmaceutically-acceptable carrier. The present invention also relates to a method for inhibiting or reducing the development of dental calculus by contacting the oral cavity with a safe and effective amount of an anticalculus agent which is a polyepoxysuccinic acid, or its pharmaceutically-acceptable salt.Type: GrantFiled: December 16, 1988Date of Patent: July 2, 1991Assignee: The Procter & Gamble CompanyInventors: James J. Benedict, Rodney D. Bush, Richard J. Sunberg
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Patent number: 5028412Abstract: Anti-calculus oral compositions include an aluminum salt and an aliphatic carboxylic acid or water-soluble salt thereof capable of complexing with the aluminum, together with a carrier suitable for use in the oral cavity. Such compositions exhibit marked effectiveness in inhibiting the formation and growth of calculus on the dental enamel.Type: GrantFiled: July 17, 1990Date of Patent: July 2, 1991Assignee: Purdue Research FoundationInventors: Mark S. Putt, Carl J. Kleber
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Patent number: 5028414Abstract: This invention relates to pharmaceutical compositions comprising anaerobe-selective antibacterial agents which are substituted or unsubstituted, 1,12-dodecanedioic peroxy acids, or their pharmaceutically-acceptable salts or esters. The pharmaceutical compositions of the present invention are especially suitable for oral administration in the form of mouth rinses and toothpastes. These anaerobe-selective antibacterial compositions are useful for treating or preventing anaerobic bacterial infections, especially diseases of the oral cavity, in humans or lower animals.The present invention further relates to a method for treating or preventing anaerobic bacterial infections such as acne, and especially diseases of the oral cavity such as gingivitis and periodontal disease, in humans or lower animals.Type: GrantFiled: November 17, 1988Date of Patent: July 2, 1991Assignee: The Procter & Gamble CompanyInventor: Padmini Sampathkumar
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Patent number: 5026539Abstract: An anti-caries composition has a source of hydrogen citrate ions, preferably an alkali metal hydrogen citrate salt, an oxalate salt and an orally acceptable excipient, and optionally further comprises an ionic fluorine-containing compound. The composition may be in the form of dentifrice when silica is the preferred abrasive, or a mouthwash.Type: GrantFiled: March 27, 1990Date of Patent: June 25, 1991Assignee: Beecham Group p.l.c.Inventors: Robert J. Jackson, Susan A. Duke, Paul Barnett
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Patent number: 5015467Abstract: Tartrate monosuccinate and tartrate disuccinate compounds of the formulae HO(CHCOOX)CH(COOX)OCH(COOX)CH.sub.2 COOX and CH.sub.2 (COOX)CH(COOX)O(CH[COOX]).sub.2 OCH(COOX)CH.sub.2 COOX are used in combination with various polymers to provide anticalculus and antiplaque effects on teeth. Oral care compositions such as dentifrices, mouthwashes, and the like, are provided. Use of the tartate-succinates and polymers in combination with other oral car ingredients such as fluoride, pyrophosphate and antibacterials is also described.Type: GrantFiled: June 26, 1990Date of Patent: May 14, 1991Assignee: The Procter & Gamble CompanyInventor: Herbert C. Smitherman
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Patent number: 5015466Abstract: Tartrate monosuccinate and tartrate disuccinate compounds of the formulas HO(CHCOOX)CH(COOX)OCH(COOX)CH.sub.2 COOX and CH.sub.2 (COOX)CH-(COOX)O(CH[COOX]).sub.2 OCH(COOX)CH.sub.2 COOX are used to provide anticalculus benefits on teeth. Oral care composition such as dentifrices, mouthwashes, and the like, are provided. Use of the tartrate-succinates in combination with other oral care ingredients such as fluoride, pyrophosphate and antibactrials is also described.Type: GrantFiled: June 26, 1990Date of Patent: May 14, 1991Assignee: The Procter & Gamble CompanyInventors: John J. Parran, Jr., Margaret M. Coyle-Rees, John T. Rotruck, Richard J. Sunberg
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Patent number: 5015468Abstract: Mixtures of tartrate disuccinate and tartrate monosuccinate enriched in the disuccinate species are prepared by reacting isomerically pure D- or L-tartaric acid with maleic anhydride in the presence of sodium hydroxide and calcium hydroxide.Type: GrantFiled: June 26, 1990Date of Patent: May 14, 1991Assignee: The Procter & Gamble CompanyInventors: Daniel S. Connor, Robert E. Stidham
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Patent number: 5004597Abstract: An oral hygiene compositions possessing antiplaque and antigingivitis properties containing stannous fluoride stabilized with stannous gluconate in an orally acceptable carrier at pH of from about 3.0% about 4.79 and said composition is substantially free of a calcium ion source.Type: GrantFiled: September 13, 1989Date of Patent: April 2, 1991Assignee: The Procter & Gamble CompanyInventors: Satyanarayana Majeti, Christopher B. Guay, Mark M. Crisanti
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Patent number: 4997640Abstract: The disclosure concerns a toothpaste having antimicrobial activity packaged in a closed container comprising water, an ascorbic acid compound consisting of ascorbic acid, an ascorbic acid salt or an ascorbic acid ester and a copper catalyst for the auto-oxidation of the ascorbic acid compound during use of the toothpaste.Type: GrantFiled: December 19, 1988Date of Patent: March 5, 1991Assignee: Chesebrough-Pond's USA Co., division of Conopco, Inc.Inventors: Nigel P. Bird, Geoffrey S. Ingram, Paul I. Riley, James A. Ritchie
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Patent number: 4992259Abstract: A stable and clear aqueous solution of zinc salt useful as a mouthrinse and a gel dentifrice. In a preferred embodiment the aqueous solution comprises zinc chloride codissolved with a complexing agent of sodium gluconate, in a naturally derived anionic polymer of sodium carboxymethylcellulose. This solution is advantageous because it maintains clarity and chemical stability in temperatures of from about 4.degree. to about 50.degree. C. and may be alcohol-free. The anionic polymer acts as a buffer to provide a solution with a pH in a desirable range of from about 5.7 to about 6.5, which limits astringency and tartness.Type: GrantFiled: January 3, 1990Date of Patent: February 12, 1991Assignee: Johnson & Johnson Consumer Products, Inc.Inventors: Michael T. Schiraldi, Robert K. Denton, Jr.
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Patent number: 4986981Abstract: A toothpaste characterized by a low abrasion, non-reactive base formulation. The toothpaste has a near neutral or neutral pH. The toothpaste contains a concentration of citric acid, sodium or potassium citrate, papain, and fine-particle-sized aluminum oxide, in particular portions which effectively clean away plaque, mucin and tartar.Type: GrantFiled: July 12, 1989Date of Patent: January 22, 1991Assignee: Den Mat CorporationInventors: William R. Glace, Robert L. Ibsen
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Patent number: 4976954Abstract: Improved anticariogenic oral preparations having a pH of about 2.5 to about 5.0 comprise an anticariogenically effective amount of a water-soluble aluminum salt in a surfactant-containing emulsion system suitable for use in the mouth.Type: GrantFiled: November 23, 1987Date of Patent: December 11, 1990Assignee: Purdue Research FoundationInventors: Carl J. Kleber, Mark S. Putt
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Patent number: 4963347Abstract: Oral hygiene compositions effective for preventing the adherent deposition of cariogenic bacteria on teeth comprise as active constituents polymers having defined repeating units comprising hydrocarbyl groups with pendant carboxyl and pendant polyalkylene oxide groups in defined ratio. The polymers themselves, their preparation, and a process for treating teeth with the compositions are also claimed.Type: GrantFiled: January 17, 1988Date of Patent: October 16, 1990Assignee: Imperial Chemical Industries plcInventors: Martyn Humphries, Jozef Nemcek, Joseph F. Jaworzyn, John B. Cantwell, John J. Gerrard
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Patent number: 4961923Abstract: Irrigants to be used with vibratory scaling apparatus and lavage are provided. The irrigants of the invention are characterized in that they contain medicaments for the treatment of conditions in the mouth and have a viscosity and deliquescence adapted to substantially optimize the efficiency of the apparatus. The irrigants are formulated so that they have minimal stickiness on drying, minimal foaming and do not gum-up the apparatus in which they are used. Also provided is a method for treating dental diseases comprising applying the irrigants of the invention through a vibratory scaling apparatus to substantially optimize the efficiency of said apparatus and to substantially optimize destruction and removal of infectious bacteria using said apparatus and the removal or inactivation of endotoxins derived from bacteria or the host.Type: GrantFiled: October 2, 1989Date of Patent: October 9, 1990Assignee: Dentsply Management Corp.Inventor: John B. Heyde
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Patent number: 4952392Abstract: Oral hygiene methods and compositions for reducing plaque and for the prevention and treatment of periodontal diseases of bacterial etiology by significantly reducing bacterial activity in the oral cavity through the inclusion of at least about 0.03% by weight of an extract of the perennial herb periwinkle in the compositions and applying the compositions to the oral cavity.Type: GrantFiled: July 27, 1989Date of Patent: August 28, 1990Assignee: Peri-Oral Dental Products, Inc.Inventor: Neville Thame
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Patent number: 4939132Abstract: This invention relates to new 5-alkylsulfonylsalicylanilides and methods for their use. More particularly, the invention relates to compounds of the formula: ##STR1## Wherein Z is a substituted or unsubstituted phenyl ring of from 6 to 30 carbon atoms including substituents, R is a substituted or unsubstituted alkylsulfonyl group of from 1 to 20 carbon atoms including substitutents; and X is a radical selected from the group consisting of --CN, --NO.sub.2, --H, halogen, lower alkyl or lower haloalkyl.The above compounds and compositions containing them are effective antiseptics against a wide range of microorganisms, especially bacteria, and are surprisingly highly effective against microorganisms, particularly S. mutans, prevalent in dental plaque.Type: GrantFiled: April 15, 1985Date of Patent: July 3, 1990Assignee: The Research Foundation of State University of New YorkInventors: Robert A. Coburn, Richard T. Evans, Robert J. Genco, Michael T. Clark
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Patent number: 4937066Abstract: An ammonium or alkali metal zinc tartrate used in oral compositions such as mouthwashes, gingival and subgingival irrigating solutions, dentifrices, and the like as well as in other preparations for treating oral lesions.Type: GrantFiled: June 22, 1989Date of Patent: June 26, 1990Assignees: David G. Vlock, Lawrence RosenInventor: Richard S. Vlock
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Patent number: 4920100Abstract: Alkyl glycosides in admixture with bactericidally active alcohols or carboxylic acids in, e.g. aqueous treatment solutions, for potentiating the microbicidal effect thereof.Type: GrantFiled: July 9, 1987Date of Patent: April 24, 1990Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Rudolf Lehmann, Klaus Hachmann, Manfred Biermann, Harald Schnegelberger
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Patent number: 4902497Abstract: Methods for reducing calculus are disclosed utilizing oral compositions containing stannous ions complexed with certain carboxylic acids or polyhydric alcohols.Type: GrantFiled: March 1, 1988Date of Patent: February 20, 1990Assignee: The Procter & Gamble CompanyInventors: Mark M. Crisanti, Anthony C. Lanzalaco, Richard J. Sunberg
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Patent number: 4900721Abstract: Liquid, aqueous disinfectants based on alcohol and hydrogen peroxide which contain one or more C.sub.2 -C.sub.8 alcohols, hydrogen peroxide or a compound which forms peroxide in aqueous phase, one or more carboxylic acids, one or more microbicidally active nitrogen-containing organic compounds, one or more microbicidally active phenolic compounds, and optionally other active substances and/or auxiliaries typically present in disinfectants, and to the use of such disinfectants for disinfection of the skin and mucous membrane.Type: GrantFiled: June 9, 1987Date of Patent: February 13, 1990Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Klaus Bansemir, Karlheinz Disch, Klaus Hachmann, Rudolf Lehmann, Manfred Biermann, Harald Schnegelberger
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Patent number: 4885363Abstract: Metal-chelating liquids having the formula ##STR1## wherein Y is oxygen or ##STR2## R.sub.Type: GrantFiled: December 23, 1987Date of Patent: December 5, 1989Assignee: E. R. Squibb & Sons, Inc.Inventors: Michael F. Tweedle, Glen T. Gaughan, James T. Hagan
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Patent number: 4880619Abstract: Oral compositions such as mouthwashes and toothpastes, creams, gels and powders containing as anticalculus agent phosphonoformic acid or salt thereof and optionally also an F-providing anticaries compound, and method of using such compositions.Type: GrantFiled: May 2, 1986Date of Patent: November 14, 1989Assignee: Colgate-Palmolive CompanyInventor: Abdul Gaffar
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Patent number: 4853213Abstract: Oral hygiene methods for reducing plaque and for the treatment of periodontal diseases of bacterial etiology by significantly reducing bacterial activity in the oral cavity through the inclusion of about 0.03% to at least about 10% by weight of a dried methanol extract of the perennial herb periwinkle in compositions and applying the compositions to the oral cavity.Type: GrantFiled: March 16, 1988Date of Patent: August 1, 1989Assignee: Peri-Oral Dental Products, Inc.Inventor: Neville Thame
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Patent number: 4846650Abstract: The present invention relates to oral compositions, such as dentrifices, toothpastes and mounthwashes, which provide an anticalculus benefit. These compositions comprise a safe and effective amount of an anticalculus agent which is a polyepoxysuccinic acid, or its pharmaceutically-acceptable salts, along with a pharmaceutically-acceptable carrier. The present invention also relates to a method for inhibiting or reducing the development of dental calculus by contacting the oral cavity with a safe and effective amount of an anticalculus agent which is a polyepoxysuccinic acid, or its pharmaceutically-acceptable salt.Type: GrantFiled: August 17, 1987Date of Patent: July 11, 1989Assignee: The Procter & Gamble CompanyInventors: James J. Benedict, Rodney D. Bush, Richard J. Sunberg
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Patent number: 4820507Abstract: Oral and dental hygiene preparations containing quaternary ammonium compounds of the formula ##STR1## wherein R.sup.1 is an n-alkyl group, preferably containing from 8 to 12 carbon atoms, R.sup.2 is hydrogen, a CH.sub.3 -group or a CH.sub.2 OH-group and R.sup.3 is a CH.sub.3 -group or a group of the formula --CH.sub.2 --CH(OH)--R.sup.2, A is an inorganic or organic acid anion and n is the basicity of the anion. The quaternary ammonium compounds of formula I can have a plaque inhibiting effect and show only slight antimicrobial activity. R.sup.1 is preferably an n-decyl group, R.sup.2 is hydrogen and R.sup.3 is a CH.sub.3 -group or a 2-hydroxyethyl group. The oral and dent al hygiene preparations also preferably contain fluorides and/or organophosphonates as the anion A.Type: GrantFiled: March 2, 1987Date of Patent: April 11, 1989Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Hans-Juergen Klueppel, Walter Ploeger, Horst Rutzen, Rudolf Lehmann
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Patent number: 4737359Abstract: Plaque is inhibited and oral hygiene promoted including reduction in caries formation by dispersing emulsan in water and contacting the aqueous dispersion with dental surfaces. Emulsan may be dispersed in dental preparation toothpaste or mouthwash.Type: GrantFiled: September 8, 1986Date of Patent: April 12, 1988Assignee: Colgate-Palmolive CompanyInventors: Edward Eigen, Alexander J. Simone
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Patent number: 4705680Abstract: Dental cream stabilized for contact with a polyolefin resin surface of a package such as a laminate tube, a mechanical dispenser or a flexible sachet. The dental cream contains a dentally acceptable water-insoluble alkaline earth metal salt, a liquid vehicle and a gelling agent. The liquid vehicle contains water, glycerine and sorbitol and a vegetable oil as an additive to reduce syneresis due to contact between the dental cream and the polyolefin resin.Type: GrantFiled: January 22, 1986Date of Patent: November 10, 1987Assignee: Colgate-Palmolive CompanyInventor: Linda J. Vellekoop
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Patent number: 4666517Abstract: An oral composition such as a mouthwash, toothpaste, gel, toothpowder, tablet, lozenge, and the like comprising a synergistic combination of tridecanol-1 and hexetidine which inhibits the formation of dental plaque.Type: GrantFiled: June 4, 1986Date of Patent: May 19, 1987Assignee: Colgate-Palmolive Co.Inventor: Shamsul Bakar
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Patent number: 4645662Abstract: An oral composition for preventing and remedying dentinal hypersensitivity which comprises containing therein aluminum and a carboxylate compound in solubilized state, with the molar ratio of the carboxylate compound to aluminum being lower than 6, and having a pH value higher than 5.Type: GrantFiled: July 25, 1985Date of Patent: February 24, 1987Assignee: Lion CorporationInventors: Syozi Nakashima, Akinori Takahashi, Nobuo Suganuma, Satoshi Ito
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Patent number: 4632824Abstract: A composition applied in the mouth which has a preventive effect on dental carries and contains such tannic acid derivatives as of solubility resistance to water.Type: GrantFiled: June 6, 1984Date of Patent: December 30, 1986Assignee: G-C Dental Industrial CorporationInventors: Kazuo Hirota, Shoji Akahane, Kentaro Tomioka
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Patent number: 4474750Abstract: A substantially anhydrous oral composition is disclosed which is substantially devoid of normally staining antibacterial antiplaque agents and which contains an effective anticalculus amount of a bis(o-carboxyphenyl) ester of a C.sub.2-8 aliphatic dicarboxylic acid such as bis(o-carboxyphenyl) succinate.Type: GrantFiled: February 24, 1983Date of Patent: October 2, 1984Assignee: Colgate-Palmolive CompanyInventors: Abdul Gaffar, John F. Gerecht
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Patent number: 4457909Abstract: A formulation of a mixture of a salt, preferably sodium chloride, and ascorbic or isoascorbic acid, when mixed in proportions by weight of 90-92% salt and 8-10% acid and dissolved in a volume of water providing a solution concentration (weight per unit volume) of 4-6% salt and 0.3-0.6% acid provides an effective oral rinse useful in bathing and cleansing mouth and throat tissues to relieve and prevent mouth and throat irritations which accompany colds, influenza and periodontal disease.Type: GrantFiled: September 27, 1982Date of Patent: July 3, 1984Inventor: Tames
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Patent number: 4431680Abstract: Described is the use of compounds defined according to the generic structure: ##STR1## wherein the dashed line represents a carbon-carbon single bond or a carbon-carbon double bond; wherein X represents the moieties: ##STR2## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent hydrogen or methyl with the proviso that (i) at least three of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent hydrogen and (ii) when the dashed line is a carbon-carbon single bond and X is: ##STR3## then one of R.sub.1, R.sub.2, R.sub.3 or R.sub.4 is methyl and the other represents hydrogen; wherein R.sub.5 represents hydrogen, and uses thereof for their organoleptic properties in augmenting or enhancing the aroma or taste of peppermint oil based oral hygiene flavors.Type: GrantFiled: October 22, 1981Date of Patent: February 14, 1984Assignee: International Flavors & Fragrances Inc.Inventor: Takao Yoshida