Abstract: Provided herein are formulations for topical and/or transdermal administration, and methods of using these formulations for the treatment of proliferative diseases related to cancer such as cancers and related conditions, and solid tumors. Also provided are formulations for topical and/or transdermal administration, and methods of using these formulations for melasma, gout, skin disorders, and other diseases and disorders described herein as well as methods for modulating the pH (e.g. raising) of a tissue or microenvironment proximal to a tumor, modulating pH, or improving the effectiveness of know chemotherapeutic agents, immunotherapy and the like for the prevention, treatment of cancers and related conditions described herein.

Abstract: Topical personal care compositions containing amino acids and 4-substituted resorcinols for potentiating glutathione synthesis within skin cells. The compositions can be used to improve skin appearance of chronological aging or photoaging, resulting from exposure to UV light/sunlight, or environmental pollutants. The compositions are also useful for attaining even skin color and reducing pigmentation, age spots and discoloration.

Abstract: A composition and article of manufacture comprising a crosslinked polymer and a method of crosslinking a polymer are disclosed. The crosslinked polymer includes a polysiloxane and at least one hydroxycinnamic acid crosslinker. The method includes obtaining a polysiloxane and at least one hydroxycinnamic acid crosslinker, and reacting the polysiloxane and the crosslinker to form a crosslinked polysiloxane.

Abstract: Provided are pharmaceutical compositions for skin lightening, which are particularly useful in treating skin hyperpigmentation, together with methods for their use. The compositions comprise glutathione conjugated to a peptide having a sequence comprising PKEK (SEQ ID NO: 1) and cysteamine or a pharmaceutical salt thereof.

Abstract: Topical personal care compositions containing amino acids and 4-substituted resorcinols for potentiating glutathione synthesis within skin cells. The compositions can be used to improve skin appearance of chronological aging or photoaging, resulting from exposure to UV light/sunlight, or environmental pollutants. The compositions are also useful for attaining even skin color and reducing pigmentation, age spots and discoloration.

Abstract: The present invention relates to the use of citrus fruit pieces, obtained by controlled osmotic dehydration of said citrus fruit in a sugar syrup, for mechanically exfoliating dead cells from the epidermis of the skin of a person. Said citrus fruit pieces include the peel and/or epicarp of said citrus fruit and have a furocoumarin compound content of less than 50 ppm.

Abstract: The present invention relates to a sunscreen formulation comprising at least one of the UV filters (A) selected from (a) triazine derivatives; (b) cinnamic acid derivatives; (c) bis-resorcinyl triazines; (f) benzimidazole derivatives; (i5) 4-Methylbenzylidene Camphor; (h) benzoyl piperazine derivatives; (j) benzoxazole derivatives; (k) diarylbutadiene derivatives; (I) phenyl benzotriazole derivatives; (n) benzylidene malonates; (o3) TEA-Salicylate; (r) imidazoline derivatives; (u) inorganic UV filters selected from metal oxides; (v) naphthalates; and (w) merocyanine derivatives; and optionally comprising at least one of the UV filters (B) selected from (d) aminobenzophenone derivatives; (e) dibenzoylmethane derivatives; (g) ?,?-Diphenylacrylate derivatives; (i5) camphor derivatives different from; (o3) salicylate derivatives different from; (p) anthranilate derivatives; and (s) benzalmalonate derivatives; wherein the ratio R of the effective irradiance for previtamin D3 formation Epvd to the effective irradia

Abstract: The application provides compositions, in particular dermatological compositions comprising extracts from argan tree for the treatment and prevention of dermatological conditions. More particularly, a composition comprising argan oil (AO), argan leaf extract (AL) and argan stem cells (ASC) is provided. Further provided is a method for reducing photoaging of the skin of a subject due to exposure to UV radiation which comprises applying the composition of the invention to the subject prior to exposure to UV radiation.

Abstract: Topical personal care compositions containing amino acids and 4-substituted resorcinols for potentiating glutathione synthesis within skin cells. The compositions can be used to improve skin appearance of chronological aging or photoaging, resulting from exposure to UV light/sunlight, or environmental pollutants. The compositions are also useful for attaining even skin color and reducing pigmentation, age spots and discoloration.

Abstract: Disclosed is a cosmetic composition comprising (i) 1 to 30 wt % of a non-hydrocarbon emollient; and (ii) 2 to 60 wt % of a blend of silicone elastomer gel of the Formula (I) and solvent; wherein the solvent for the silicone elastomer gel is selected from cyclic or linear polydimethylsiloxanes; wherein the w/w ratio of the amount of the non-hydrocarbon emollient to the combined amounts of the silicone elastomer gel and said solvent is from 1:50 to 1:1 and where the amount of the non-hydrocarbon emollient is less than the amount of the silicone elastomer gel; and wherein the composition comprises less than 2 wt % capric caprylic triglycerides and less than 5 wt % crosslinked elastomeric silicone polyether, wherein said non-hydrocarbon emollient is an alkenyl or alkyl ester of a C10-20 fatty acid, an ether-ester, a polyhydric alcohol ester, a wax ester, a mono-, di- or triglyceride, a sterol ester, a fatty alcohol, a fatty acid, lanolin or its derivative, wax ester, a phospholipid, beeswax or a sterol.

Abstract: Ultraviolet radiation sun protective compositions are reported which feature micronized metal oxide inorganic particles selected from zinc oxide, titanium oxide and mixtures thereof, the inorganic particles being coated with poly [C8-C20 hydroxycarboxylic acid], the coated particles measured at a 10% loading in dodecane and 1 minute elapsed time having a Zeta Potential ranging from 2 to 10 mv, amounts of the poly [C8-C20 hydroxycarboxylic acid] to the inorganic particles being in a relative weight ratio of 1:100 to 1:10.

Abstract: The invention provides ultraviolet light absorber suitable for use as an additive in polymers, comprising particles of inorganic oxide having UV light-absorbing compound on their surface, wherein said UV light-absorbing compound is chemically bonded, either to a spacer provided on the surface of said particle, or directly to the surface of the particle. Process for preparing the additive absorber and a thermoplastic polymer (e.g., a film) comprising the absorber additive are also provided.

Abstract: A method of producing efficiently and stably core-shell type oxide particles, wherein the entire surface of the core oxide particles is uniformly coated with the shell oxide, includes at least two steps of: Step 1 of precipitating the core oxide particles in a mixed fluid prepared by mixing an oxide raw material liquid for core and an oxide precipitation solvent and Step 2 of coating the entire surface of the core oxide particles uniformly with the shell oxide by mixing the mixed fluid and an oxide raw material liquid for shell.

Abstract: A detergent composition for partial cleaning is disclosed. The detergent composition for partial cleaning includes a) a polymer represented by the following Formula 1, b) a nonionic surfactant represented by the following Formula 2, c) a nonionic surfactant represented by the following Formula 3, d) a nonionic stain release agent (SRN), e) a water-soluble solvent, and f) water, wherein the a) polymer represented by Formula 1 is present in an amount of 1 to 10% by weight and has a viscosity of 20,000 cps or more.

Abstract: A polyvinyl alcohol has a number-average molecular weight (Mn) from 4,400 to 440,000, a molecular weight distribution (Mw/Mn) from 1.05 to 1.70, a degree of saponification from 80 to 99.99 mol %, and a carbon-carbon double bond content (X) of 0.1 mol % or less based on total monomer units, and satisfying a formula (1) below. A polyvinyl alcohol, having a narrow molecular weight distribution and a high number-average molecular weight with good hue, and a method for producing the same are thus provided.

Abstract: Disclosed are methods of treating aging effects on a subject skin, comprising contacting the skin with a skin microbiome complex, including topical compositions containing YM Microbiome Complex and Advanced Probiotic Complex, methods of treatment using the compositions and methods of preparing the compositions for preventing, slowing, and reversing skin aging. Also disclosed are related formulations and methods of skin microbiome transplantation.

Abstract: A method of preparing a fine oil-in-water emulsion comprising an oil phase based on silicone and/or hydrocarbon oils, in which the oil phase particles have an average particle size of 150 nm or less. The emulsion is stabilized by a carboxy-modified silicone in combination with a C16 to 22 higher alcohol; a nonionic surfactant having a POE chain and an HLB of 5 to 10; and a dihydric glycol. The emulsions can be prepared without the use of a high-pressure emulsifying apparatus.

Abstract: The present invention is a composition in form of an emulsion, comprising at least one fatty phase, and at least one aqueous phase, and: a) at least one first surfactant chosen from C8-C22 alkyl dimethicone copolyols; b) at least one second surfactant chosen from dimethicone copolyols, which is different from the first surfactant a); c) at least one third surfactant which is different from the first or the second surfactant a) or b), having a HLB value of greater than or equal to 8; and d) at least one hydrophilic pigment.

Abstract: The invention relates to a composition comprising: (a) one or more alkoxysilanes comprising solubilizing function(s) of formula R1Si(OR2)z(R3)x(OH)y, and/or hydrolysis products thereof and/or oligomers thereof, (b) one or more of formula (R4)mSi(OR5)n and/or hydrolysis products thereof and/or oligomers thereof, et (c) one or more surfactants. It also relates to the use thereof for cleansing and/or conditioning keratin fibres.

Abstract: A slurry is made with ground cannabis biomass and a non-flammable co-solvent. The non-flammable co-solvent is made up of water and ethanol. The ultrasonication process extracts cannabinoids by applying ultrasound to the slurry. The slurry is then filtered, optionally centrifuged, and then distilled to obtain cannabinoid oil.

Abstract: The invention provides a pain therapy cream comprising an anhydrous topical delivery formulation for percutaneous absorption comprising an anhydrous carrier medium, a chemical exfoliant, a penetration enhancer, and one or more pain killing agent selected from the group consisting of an analgesic, anesthetic, anti-inflammatory, or antipruritic agent, a phytochemical and other painkilling active ingredients, and methods of using the pain therapy cream.

Abstract: Cosmetic peeling cream, comprising a) an oil-in-water emulsion, containing (i) at least one fatty substance, (ii) at least one C12-C24 fatty alcohol, (iii) at least one co-emulsifier, and (iv) at least one thickening agent; b) a peeling agent, wherein the constituents a) and b) are present in a total ratio of a) to b) of from about 9:1 to about 1:1. Also provided are the use of the peeling cream, the method and application of said cream, as well as the method for the production thereof.

Abstract: A personal care composition is disclosed comprising from 1 to 90% by weight of a hydrocarbon oil of an average carbon chain length with 8 or higher carbon atoms; a blend of silicone elastomer and solvent; and a cosmetically acceptable carrier; wherein the solvent is a volatile silicone oil selected from octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, blends of methyl trimethicone and dimethicone and mixtures thereof; and wherein the silicone elastomer has the chemical structure of formula I.

Abstract: The disclosure relates to an aqueous cosmetic composition that includes at least one effect pigment is present up to about 0.02 wt %, an emulsion of at least one oil and at least one surfactant, and at least one active selected to provide one or more benefits, including, but not limited to brightening/whitening, improvement of skin tone, blemish control or reduction, reduction of redness, anti-aging, and hydration, in an aqueous solvent. The composition may include a thickener and a preservative. Methods include forming the composition and applying the composition to the skin to provide an instant “glowing” or “brightening” effect.

Abstract: The present invention relates to topical compositions comprising at least one inorganic micropigment and a cetyl phosphate surfactant mixture consisting essentially of mono- and/or dicetyl esters of phosphoric acid or salts thereof and cetylalcohol and inorganic phosphate and heavy metals and water, characterized in that the surfactant mixture contains no organochlorine impurities and has an inorganic phosphate content of less than 0.7 wt.-% and a heavy metal content of less than 12 ppm.

Abstract: The invention relates to emulsions containing (a) at least one UV sunscreen factor, (b) at least one compound of formula (I) where R1 is II or CII3 and R2 is II or COOII or salts thereof, (c) at least one emulsifier, and optionally (d1) a carrier and/or (d2) an oil body, providing that the emulsions have a droplet size at which the D50 value ranges from 0.1 to 100 ?m.

Abstract: Zinc oxide compositions and methods for controlling zinc oxide particle size for sunscreen applications are provided herein. A method includes manipulating the size of multiple zinc oxide particles to be below a maximum threshold; selecting one or more media to be used in a sunscreen composition, wherein said selecting is based on the refractive index of each of the media; and integrating the manipulated zinc oxide particles into the selected media to create the sunscreen composition. A composition includes multiple zinc oxide particles, wherein each of the zinc oxide particles is (i) coated with an optical coating material and (ii) of a size that is below a maximum threshold; and a medium layer within which the zinc oxide particles are suspended, wherein the medium layer comprises a mixture of one or more media, and wherein each of the media has a refractive index below a predetermined threshold.

Abstract: A lip balm composition includes a composition including petroleum jelly, camphor, menthol, phenol, beeswax, and cannabis.

Abstract: A photostable UV-A/UV-B-sunscreen composition is provided. The composition includes an oil in water or water in oil emulsion, wherein the emulsion includes at least one photostabilizer having anti-oxidant properties, at least one SPF booster, and at least one UV-A filter and at least one UV-B filter. The UV-A/UV-B sunscreen composition is provided in which the composition is essentially free of oxybenzone.

Abstract: Antiviral pharmaceutical compositions comprising one or more cannabinoid compounds in the form of lip-balms, creams and ointments. A specific embodiment provides a topical composition formulated as a lip-balm.

Abstract: An encapsulated sunscreen composition that includes a polymeric shell material having a substantially spherical geometry. The shell material is a polymeric composition that includes a photosensitizer chemically bound to the polymeric composition. The polymeric shell material has a minimum diameter of 100 nm.

Abstract: Sun-care products are described that protect from UV radiation and do not turn white when applied to wet skin. The sun-care product may comprise (A) a cosmetically-acceptable, substantially non-aqueous vehicle, and (B) a UV active, wherein said non-aqueous vehicle comprises alcohol in an amount of 50% (w/w) or less based on the weight of the sun-care product and an ester wherein said non-aqueous vehicle comprises at least 10%>by weight esters based on the total weight of the non-aqueous vehicle and said sun-care product is substantially non-whitening upon application to wet skin.

Abstract: The present disclosure relates to new UV-filters, method of producing the same and their use in compositions in particular, cosmetic/pharmaceutical or textile compositions, namely sunscreens cream or sunscreens textile article, in particular the present disclosure relates to hydroxyapatite based-compound comprising Ca9FeH(PO4)7 and/or ?-Fe2O3 in hematite form for use in a method for protecting the skin against UV radiation.

Abstract: The present invention features, inter alia, biocompatible compositions that include a poloxamer and one or more additives such as hyaluronic acid, gelatin, fibronectin, or a peptide fragment of fibronectin. The compositions are useful in tissue repair or remodeling, including repair of an injured spinal disc, in drug delivery, in cell culture, and in inhibiting the formation of adhesions.

Abstract: Methods of making safe extracts of Curcuma longa L. are provided. The processes provided include methods that use an extraction solvent that is at least substantially non-toxic and useful also as a pharmaceutically acceptable carrier in liquid dosage forms. The processes can produce a significantly higher yield from a single extraction than the state-of-the-art processes. For example, liquid dosage forms can be produced directly from the extraction process without requiring removal of the extraction solvent, reducing complexity and cost of processing over the state-of-the-art. Methods of making microemulsions and nanoemulsions are also provided to enhance the bioavailability and stability of the extracts.

Abstract: A pharmaceutical composition based on centella asiatica (Hydrocotyle asiatica L.) for the treatment of lower limb ulcers, including as active ingredients, centella asiatica and sodium acexamate in amounts producing a reciprocal synergistic effect when mixed with at least one adjuvant selected from a healing agent, an antibiotic agent and/or combinations thereof is described.

Abstract: The present invention has an object to provide an external dermal composition for anti-ageing, which prevents or improves apparent skin problems such as wrinkles, fine wrinkles, blemishes, and saggings caused by increasing age or ageing; and maintains or improves the barrier function and the hyaluronic acid production in the skin. The object is solved by providing an external dermal composition for anti-ageing, which contains an aqueous medium as a base material and one or more ingredients selected from L-ascorbic acid, derivatives thereof, and their salts as an effective ingredient(s).

Abstract: The present invention relates to organosilicon polymers containing benzoic acid esters in form of particles, process for their preparation, cosmetic or dermatological composition comprising them, as well as their use for protecting a human or animal living body from UV radiation.

Abstract: Pharmaceutical compositions comprising a first anti-acne compound, a second anti-acne compound, and an anti-photoaging compound are described. Methods for the treatment of acne and photoaging using the compositions are also described.

Abstract: Compositions and methods useful in the reduction of localized fat deposits and tightening of loose skin in subjects in need thereof using pharmacologically active detergents are disclosed. The pharmacologically active detergent compositions can additionally include anti-inflammatory agents, analgesics, dispersion or anti-dispersion agents and pharmaceutically acceptable excipients. The pharmacologically active detergent compositions are useful for treating localized accumulations of fat including, for example, lower eyelid fat herniation, lipodystrophy and fat deposits associated with cellulite and do not require surgical procedures such as liposuction.

Abstract: Disclosed is a topical skin composition comprising a glyceryl di-salicylate or a glyceryl di-benzoate compound having the following structure: where R is OH or H, and where the composition further includes a glyceryl mono-salicylate compound or a glyceryl mono-benzoate compound.

Abstract: The present invention relates to an anhydrous composition in cream form, characterized in that it comprises, in a cosmetically acceptable support: (a) at least one oily phase; (b) at least one non-emulsifying elastomeric organopolysiloxane; (b) a photoprotective system capable of screening out UV radiation; (c) at least one matting agent; (d) at least one non-silicone organic thickener for the oily phase, chosen from: (1) crystalline polymers, preferably semi-crystalline polymers, (2) fatty acid esters of dextrin, (3) hydrophobic-modified polysaccharides, (4) crystalline olefin copolymers, (5) crystalline polycondensates, (6) polymers of lipophilic polyamide type, (7) lipophilic polyureas and polyurethanes, (8) block polymers, (9) cholesterol-based liquid-crystal agents and mixtures thereof; the said composition not comprising any humectant.

Abstract: A composition which includes a) ferulic acid ethyl ester and b) one, two or more aryl alkanols. The combination of components a) and b) has an antimicrobial effect on products such as cosmetics.

Abstract: The present invention relates to compounds of general formula (I): wherein Y, R1, R2 and R3 are as defined in the specification. The invention also relates to cosmetic or dermocosmetic composition containing such compounds. The compounds according to the invention are useful as photoprotective agents.

Abstract: Described herein are methods and compositions for increasing dermal concentrations of glycosaminoglycans (GAG), including hyaluronic acid. Exemplary methods involve a one-step protocol and a three-step protocol. Either method can be used over a 90-day treatment period.

Abstract: A polymer composition comprising a linear ultraviolet radiation absorbing polyether that comprises a chemically bound UV-chromophore.

Abstract: Articles of manufacture, such as paper towels, that contain polymer particles, for example water-soluble polymer particles, for example water-soluble soil adsorbing polymer particles and processes for making same are provided.

Abstract: A transdermal preparation comprising a multivalent metal chloride, a basic drug having an amino group, and an ester group-containing base material, is useful because of its excellent drug content stability.

Abstract: The present application relates to sunscreen formulations, including foamable sunscreen formulations, that comprise zinc oxide and titanium dioxide particles, suitably in the size range of about 1-100 nm. The compositions suitably produce a minimal residual whitening effect when applied to a skin surface.

Abstract: Disclosed is a method of preserving a cosmetic or pharmaceutical formulation, the method comprising including a mixture of at least two of the following esters of salicylic acid and glycerin, or salts thereof, in the cosmetic or pharmaceutical formulation in an amount sufficient to reduce or inhibit growth of a microorganism in the cosmetic or pharmaceutical formulation: