Heavy Metal Containing Patents (Class 424/604)
-
Patent number: 6921544Abstract: A stable, phase-pure magnesium-substituted crystalline hydroxyapatite containing from about 2.0 to about 29 wt % magnesium, wherein at least 75 wt % of the magnesium content is substituted for calcium ions in the hydroxyapatite lattice structure.Type: GrantFiled: March 6, 2001Date of Patent: July 26, 2005Assignee: Rutgers, The State UniversityInventors: Richard E. Riman, Wojciech Suchanek, Pavel Shuk, Kevor S. TenHuisen
-
Patent number: 6911470Abstract: Polyoxometalate compounds which exhibit anti-retroviral activity are disclosed. Compounds with anti-retroviral activity include those having the following general molecular formulas: M7PW11O39 M8SiW11O39 M9HSiW9O34 M8HPW9O34 M10(TM)4(PW9O34)2 M16(TM)4(P2W15O56)2 M14[NaP5W30O110] M12(TM)3(PW9O34)2 M6P2W18O62 wherein M is an alkali metal, NH4+ or other common monocation or soluble dication, or any combination of the above provided adequate water solubility is exhibited, or histidinium ion, argininium ion, or lysinium ion or any dication of a dipeptide or oligopeptide with 2 protonated basic amino acid residues, or any combination of these monocations or dications with each other or with any common inorganic cation, and TM is a divalent transition metal ion, such as Mn, Fe, Co, Ni, Cu and Zn.Type: GrantFiled: October 25, 1993Date of Patent: June 28, 2005Inventors: Raymond F. Schinazi, Craig L. Hill
-
Patent number: 6881424Abstract: A highly acidic metalated organic acid composition and its preparation. The acidic composition can be prepared by mixing a monovalent or polyvalent cation and an organic acid in the presence of a strong oxyacid, wherein the resultant acidic composition is less corrosive to a ferrous metal than a solution of a mineral acid having the same acidic pH value as that of the acidic composition, and where in the acid composition is more biocidal than a mixture of the organic acid and a metal salt of the organic acid which mixture has the same acid normality value as that of the acidic composition. The acidic composition can be prepared by mixing at least one regenerating acid, at least one metal base, and at least one organic acid, wherein the amount of the regenerating acid is in excess of the equivalent amount of the metal base.Type: GrantFiled: September 5, 2000Date of Patent: April 19, 2005Assignee: Mionix CorporationInventors: Maurice Clarence Kemp, Robert Blaine Lalum, David E. Lewis, Robert H. Carpenter
-
Patent number: 6855341Abstract: Disclosed are anti-viral compositions containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients), and a pharmaceutical carrier. Also disclosed are methods of treating lesionous symptoms of a viral infection involving applying an effective amount of the anti-viral composition to the lesions.Type: GrantFiled: November 4, 2002Date of Patent: February 15, 2005Inventor: Jeffrey B. Smith
-
Patent number: 6849276Abstract: The invention concerns a phytosanitary fungicide, bactericidal or bacteriostatic composition comprising at least a mineral salt, a copper oxide or hydroxide suspended in an aqueous emulsion of at least a terpene derivative.Type: GrantFiled: August 24, 1999Date of Patent: February 1, 2005Assignee: Action PinInventors: Ghislain Dufau, Michel Barsacq, Gérard Molla
-
Patent number: 6833362Abstract: A composition for accelerating the disposal of ethanol from bodily fluid. Certain additives can accelerate the metabolic oxidation of ethanol, and others in addition act as catalysts or “pseudo” enzymes for the oxidation. Additives include the oxidant Nicotinamide Adenine Dinucleotide and a variety of other additives such as transition metal ions and complexes thereof which favor the oxidation reaction. The compositions described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.Type: GrantFiled: June 7, 2001Date of Patent: December 21, 2004Inventors: Ward Beryl Bowen, Jr., Daniel Salman Daniel
-
Publication number: 20040241251Abstract: Random or block co- or terpolymers produced by using metal complex catalysts in a reaction of one conjugated diene monomer with one aromatic Random or block co- or terpolymers produced by using metomers with one aromatic &agr;-olefin or terpolymers of one conjugated diene monomer with one aromatic &agr;-olefin and one aliphatic &agr;-olefin by using metal complexes comprising metals of group 3 to 10 of the Periodic System of the Elements in combination with activators and optionally a support material. More particularly the metal complexes used for the synthesis of co- or terpolymer are lanthanide metals. Even more particularly diene monomer(s) and aromatic &agr;-olefin monomer(s) such as, but not limited to, butadiene and styrene or isoprene and styrene are copolymerized giving random or block copolymers or butadiene, styrene and isoprene are terpolymerized giving random or block terpolymers using metal complexes comprising lanthanide metals in combination with activators and optionally a support material.Type: ApplicationFiled: October 3, 2003Publication date: December 2, 2004Inventors: Sven K H Thiele, Victor M. Monroy, David R. Wilson
-
Patent number: 6824794Abstract: A water treatment agent and method of treating water to inhibit, reduce, or prevent the formation of algae and bacteria in a water body. The water treatment agent may include copper sulfate penta-hydrate and/or silver, di-sodium ethylene di-amine tetra-acetic acid dihydrate, a scale inhibitor, a shocking agent and a buffer agent. For instance, the treatment agent may include a composition of copper sulfate pentahydrate, di-sodium ethylene di-amine tetra-acetic acid, monopotassium phosphate or sulfuric acid, and potassium monopersulfate and 1-hydroxyethylidene-1,1-diphosphonic acid.Type: GrantFiled: May 31, 2002Date of Patent: November 30, 2004Assignee: Innovative Water Technologies, Inc.Inventors: Terry A. Ring, Tom Smolkov, M. Anthony Gamarra
-
Publication number: 20040228880Abstract: The present invention relates to vaccine compositions comprising iron phosphate as adjuvant. This iron phosphate is in the form of particles, the size of which is between 0.01 &mgr;m and 300 &mgr;m; it can be obtained by mixing a solution of iron salt and of phosphate salt.Type: ApplicationFiled: May 14, 2004Publication date: November 18, 2004Applicant: Aventis Pasteur SAInventor: Elisabeth Sauzeat
-
Publication number: 20040228794Abstract: Disclosed herein are therapeutic agent carrier compositions that include a carrier comprised of a stimulus sensitive gel, fibrin, or combinations thereof, and a therapeutic agent such as an aqueous insoluble or confined radioisotope. Stimulus sensitive gels include thermally reversible stimulus-sensitive gels that are linear random copolymers of a [meth-]acrylamide derivative and a hydrophilic comonomer; thermogelling biodegradable polymers, which include biodegradable polymers including a linked polyethylene glycol (PEG) block and biodegradable polyester block; and enzymatically degradable polypeptide poylmers. In certain embodiments the therapeutic agent is a hydrothermally synthesized radioactive therapeutic agent, such a 90-yttrium phosphate colloid. Methods of making such carrier compositions and methods of using such carrier compositions to treat diseases such as cancer also are disclosed.Type: ApplicationFiled: February 19, 2004Publication date: November 18, 2004Applicant: Battelle Memorial InstituteInventors: Richard E. Weller, Darrell R. Fisher, Michael A. Lind, Allison A. Campbell, Anna Gutowska, Craig F. Habeger
-
Patent number: 6803057Abstract: An acidic aqueous hydrogen peroxide solution is provided with improved disinfectant activity. Concentrated solutions preferably contain up to about 8 wt./wt. % H2O2 and as-used concentrations contain about 0.5% wt./wt. % H2O2. The solution also contains from 0.05 to 8.0 wt./wt. % of at least one phosphorous-based acid, e.g. phosphoric acid and/or a phosphonic acid with from 1 to 5 phosphonic acid groups, and from 0.02 to 5 wt./wt. % of at least one anionic surfactant. The surfactant is selected from C8 to C16 alkyl aryl sulfonic acids, sulfonated C12 to C22 carboxylic acids, C8 to C22 alkyl diphenyl oxide sulfonic acids, naphthalene sulfonic acids, C8 to C22 alkyl sulfonic acids, and alkali metal and ammonium salts thereof, and alkali metal C8 to C18 alkyl sulfates, and mixtures thereof. Most preferably the solution has an emulsifier and/or hydrotrope, e.g. an alkylated sulfonated diphenyl oxide salt, an alkyl aryl polyoxyethylene surfactant, and/or a polyoxyethylene surfactant.Type: GrantFiled: December 28, 2001Date of Patent: October 12, 2004Assignee: Virox Technologies Inc.Inventors: Jose A. Ramirez, Michael J. Rochon
-
Publication number: 20040180098Abstract: Improved powder coatings exhibit enhanced resistance to bacterial and fungal attack, while possessing excellent toughness, appearance, corrosion resistance, durability, processability, and ease of application. The coating is comprised of anti-microbial agents that are homogeneously dispersed within the powder or impact fused to powder particles or both. An article may be coated with a thermoset thermoplastic, or radiation curable powder, which may be applied by electrostatic spray or fluidized bed or by thermal or flame spray.Type: ApplicationFiled: March 24, 2004Publication date: September 16, 2004Inventors: Owen H. Decker, Michael A. Sparks, Jeffrey R. Hagerlin, Frederick L. Cummings, Peter Gottschling
-
Publication number: 20040175431Abstract: A method of administering iron to dialysis patients is accomplished by infusion of a noncolloidal ferric compound, soluble in hemodialysis or peritoneal dialysis solutions, by the process of dialysis. A pharmaceutical composition is provided consisting essentially of dialysis solution including a soluble noncolloidal ferric compound, preferably ferric pyrophosphate.Type: ApplicationFiled: March 9, 2004Publication date: September 9, 2004Inventor: Ajay Gupta
-
Publication number: 20040170700Abstract: The present invention provides an antibacterial glass composition exhibiting high antibacterial performance with sufficiently sustaining antibacterial performance by adding a small amount of the antibacterial component, and an antibacterial polymer composition using the antibacterial glass composition. The present invention provides an antibacterial glass composition containing 0.1 to 5.0% by weight of Ag2O in a glass composition containing 30 to 60 mol % of P2O5, 1 to 15 mol % of one or more compounds selected from the group consisting of K2O, Na2O and Li2O, 35 to 55 mol % of one or more compounds selected from the group consisting of MgO, CaO and ZnO, and 0.01 to 3 mol % of one or more compounds selected from the group consisting of La2O3 and Y2O3.Type: ApplicationFiled: November 26, 2003Publication date: September 2, 2004Applicant: ISHIZUKA GARASU KABUSHIKI KAISHAInventors: Minoru Numaguchi, Makio Nomura
-
Patent number: 6764692Abstract: A method of treating laminitis in a horse is disclosed, comprising administering to the horse a naturally chelated trace mineral composition; promoting healthy skin, hair and hoof tissue. A method of reducing dietary intake is also disclosed, comprising administering to a horse in need thereof, effective amounts of a naturally chelated trace mineral composition. A method of preparing the chelated trace mineral composition from ocean seabed rock is further disclosed, as well as the chelated trace mineral composition.Type: GrantFiled: August 27, 2002Date of Patent: July 20, 2004Inventor: Carlos Cortelezzi
-
Patent number: 6761912Abstract: A composition and a method for administering an improved supplement to prevent bone density loss. The composition combines a calcium compound with inulin, and optionally magnesium, Vitamin D3, Vitamin K, Vitamin C, and may combine a soy isoflavone, all in a dietary acceptable form in a beverage, a beverage preparation, a paste, a bar, or a cookie.Type: GrantFiled: October 25, 2001Date of Patent: July 13, 2004Assignee: Pharmavite LLCInventors: Samuel L. Forusz, Hanlan Liu, Rose M. Muatine
-
Patent number: 6753016Abstract: A method for the protection of wood and other wood materials without affecting dimensional stability or surface integrity of the treated material is described. The method involves treating wood material with an iron salt and selected oxidants where the iron salt is preferably complexed with organic chelating ligands. Preferably, a microbicidal agent is also incorporated into the method to provide treated wood products that demonstrate excellent surface integrity, dimensional stability and retention of the infused microbicidal agents for extended periods of time without incurring the detrimental environmental effects of conventional chromium or copper-based inorganic salt preservation methods.Type: GrantFiled: June 6, 2002Date of Patent: June 22, 2004Assignee: Rohm and Haas CompanyInventor: Tirthankar Ghosh
-
Patent number: 6723349Abstract: The invention relates to a polyoxometalate topical composition for removing a contaminant from an environment, comprising a topical carrier and at least one polyoxometalate, with the proviso that the polyoxometalate is not H5PV2Mo10O40; K5Si(H2O)MnIIIW11O39; K4Si(H2O)MnIVW11O39; or K5CoIIIW12O40. The invention further relates to a method for removing a contaminant from an environment, comprising contacting the polyoxometalate topical composition of the present invention with the environment containing the contaminant for a sufficient time to remove the contaminant from the environment. The invention further relates to a modified polyoxometalate, wherein the modified polyoxometalate comprises the admixture of (1) a polyoxometalate and (2) a cerium compound, a silver compound, a gold compound, a platinum compound, or a combination thereof.Type: GrantFiled: October 11, 2000Date of Patent: April 20, 2004Assignee: Emory UniversityInventors: Craig L. Hill, Ling Xu, Jeffrey T. Rhule, Eric A. Boring
-
Patent number: 6723350Abstract: The invention provides methods and kits to form water swellable gel coatings, preferably lubricious coatings, on substrates, and coated substrates thus formed. The coatings contain one or more antimicrobial metals formed with atomic disorder, together with one or more antimicrobial metals formed with atomic disorder such that the coatings provide an antimicrobial and anti-inflammatory effect when wet. The invention also provides a method to produce metal powders by sputtering a coating onto a moving surface, and then scraping the coating with one or more scrapers to produce the metal powder. The method is particularly useful for producing large amounts of nanocrystalline antimicrobial metal powders formed with atomic disorder, useful in the water swellable gel coatings of this invention.Type: GrantFiled: April 23, 2002Date of Patent: April 20, 2004Assignee: Nucryst Pharmaceuticals Corp.Inventors: Robert Edward Burrell, Hua Qing Yin, Antony George Naylor, Peter Howard Moxham, Walter Carlton Theodore Cholowski, Leonard Salvin Bowlby, David James Field
-
Patent number: 6713076Abstract: The invention relates to a method for removing a contaminant from a gas phase or a liquid phase by contacting an article composed of (1) a fabric or cellulosic fiber and (2) a polyoxometalate, wherein the polyoxometalate is incorporated in the fabric or cellulosic fiber, with the gas phase or liquid phase containing the contaminant. The invention further relates to a polyoxometalate-modified fabric composed of a fabric and a polyoxometalate of the present invention incorporated in the fabric. The invention further relates to an article containing the polyoxometalate-modified fabric. The invention further relates to a method for making the polyoxometalate-modified fabric, by contacting the fabric with a polyoxometalate to produce a polyoxometalate-modified fabric.Type: GrantFiled: December 4, 2000Date of Patent: March 30, 2004Assignee: Emory UniversityInventors: Craig L. Hill, Ling Xu
-
Publication number: 20040058011Abstract: A non-toxic, germicide, fungicide and healing composition and a method of topically applying the composition in powdered form to the skin of domesticated farm animals including dairy cattle are disclosed. The composition comprises (a) finely divided, particulate chlorhexidine-containing material, (b) finely divided, particulate zinc-containing material and (c) an inert powdered carrier, with the chlorhexidine-containing material and the zinc-containing material being present in an amount to achieve effective germicidal activity. The chlorhexidine-containing material is preferably chlorhexidine acetate. The zinc-containing material is preferably selected from the group consisting of zinc stearate, zinc chloride, zinc nitrate, zinc oleate, zinc oxide, zinc phosphate, zinc peroxide, zinc iodide, elemental zinc and mixtures thereof.Type: ApplicationFiled: September 10, 2003Publication date: March 25, 2004Inventor: Lennart G. Petersson
-
Patent number: 6706683Abstract: A method of controlling granule secretion comprising performing a treatment to increase or decrease an active form of calgranulin on a cell line having capability of secreting granules, thereby increasing or decreasing granule secretion from the cell line. A method of detecting a substance which inhibits or activates the granule secretion reaction by applying this controlling method. An active form of calgranulin is increased by making the cells permeabilized cells and adding a calgranulin and soluble calcium. Decrease of an active form of calgranulin is carried out by introducing a calgranulin antibody into cells. The method is useful for screening a substance which inhibits or activates granule secretion.Type: GrantFiled: March 29, 2001Date of Patent: March 16, 2004Assignee: Asahi Kasei Pharma CorporationInventors: Minoru Seto, Kouichirou Fukuda
-
Patent number: 6689392Abstract: A composition for controlling growth of pathological organisms on a plant, said composition comprises an effective amount of one or more of metal ion(s); one or more of chelating agent(s); and phosphorous acid, and/or salt or hydrate thereof, said composition is in an agriculturally compatible carrier or vehicle.Type: GrantFiled: January 29, 2002Date of Patent: February 10, 2004Assignee: Agricare Ltd.Inventor: Ran Lifshitz
-
Patent number: 6660289Abstract: The invention concerns an oxidising aqueous composition useful in particular for disinfection, hygiene and depollution purposes, and for surface treatment (particularly a metal surface to be stripped and/or passivated), and said composition, containing in water hydrogen peroxide, a RCO2H/RCO3H mixture (wherein R is a C1-C6 aliphatic radical with linear or branched hydrocarbon chain, saturated or unsaturated), a stabilising agent which is an acid and, as the case may be, Ag+ ions. The invention is characterised in that it contains ions of at least one metal M which are ions of AgII, AgIII, VV, NbV, TaV, MoVI, WVI, CoIII, InIII or TlIII. Advantageously, said composition can be in gel form. The invention also concerns the method for preparing said composition.Type: GrantFiled: October 23, 2001Date of Patent: December 9, 2003Assignee: Digol International LTDInventors: Rémi Wilmotte, Bernard Lebeau, Jean-Pierre Irurzun, Françoise Marechal
-
Publication number: 20030215521Abstract: Improvements in increasing the amount of surface-available silver in thermoplastic articles comprising certain silver-containing antimicrobial agents. Such an invention requires the incorporation of a sufficient amount of a carboxylic acid salt within the thermoplastic article simultaneously with the necessary silver-containing antimicrobial agent. Certain carboxylic acid salts are standard acid scavengers and lubricants for certain thermoplastic applications; however, the amounts required within this inventive thermoplastic article are in excess of that commonly added within such articles, and the types of acid scavengers possibly added within such target thermoplastic articles are preferably neutralized hydrotalcite compounds, thereby permitting the carboxylic acid salt to function in the inventive manner.Type: ApplicationFiled: June 4, 2003Publication date: November 20, 2003Inventors: Erik Laridon, Geoffrey Haas, Robert Dankel
-
Publication number: 20030118658Abstract: The invention relates to a high aspect ratio microcapsule comprising an inorganic antimicrobial agent coated with a hydrophilic polymer. The hydrophilic polymer is able to absorb sufficient water as to enable the action of the encapsulated antimicrobial agent. These high aspect ratio microcapsules are useful to impart antimicrobial activity and can be used in polymer compositions, sprays and coatings. A method of preparing the high aspect ratio microcapsule by melt compounding and fabrication of the antimicrobial agent with the hydrophilic polymer is provided. Polymer compositions comprising the high aspect ratio microcapsules and a matrix polymer are also provided. Another embodiment of the invention is an article prepared from the polymer compositions comprising the high aspect ratio microcapsules and a matrix polymer.Type: ApplicationFiled: December 21, 2001Publication date: June 26, 2003Inventors: Jeffrey A. Trogolo, Frank C. Rossitto, Edward K. Welch
-
Patent number: 6582719Abstract: The present invention relates to compositions comprising a combination of one or more antiseptic and an antibiotic. It is based, at least in part, on the discovery that such combinations tend to deter the formation of antibiotic-resistant organisms. In preferred, nonlimiting embodiments of the invention, the antibiotic is minocycline and the antiseptic is a chlorhexidine compound, triclosan, or benzalkonium chloride, and in particular embodiments, a silver salt or a bismuth salt is added. Examples of specific, nonlimiting embodiments of the invention include combinations of (i) minocycline, triclosan, and a bismuth salt; (ii) minocycline, a chlorhexidine compound, and a bismuth salt; and (iii) minocycline, benzalkonium chloride, and a bismuth salt. The present invention further provides for articles, such as, but not limited to, medical articles, which have been treated with or which otherwise comprise a combination of antiseptic and antibiotic.Type: GrantFiled: February 2, 2001Date of Patent: June 24, 2003Assignee: The Trustees of Columbia University in the City of New YorkInventors: Shanta M. Modak, Suhas Tambe, Lester A. Sampath
-
Patent number: 6565892Abstract: Synergistic fungicidal composition comprising a compound analogous to strobilurin of formula (I): in which: A is the nitrogen atom or the —CH group, B is the —OCH2— or —CH2O— or CH(CH3)—O—N═CH— or —CH═N—O—CH(CH3)— group or the group R1 is an alkyl group containing 1 to 4 carbon atoms, R2 is —OCH3 or —NHCH3, X is a halogen atom, the cyano group or an alkyl or haloalkyl group containing 1 to 4 carbon atoms, n is equal to 1 or 2, with, when n is equal to 2, the possibility of having different X groups, and at least one fungicidal compound B, and a process for the curative or preventive control of phytopathogenic fungi using the composition.Type: GrantFiled: July 3, 2001Date of Patent: May 20, 2003Assignee: Rhone-Poulenc AgrochimieInventor: Patrice Duvert
-
Patent number: 6565891Abstract: A multinutrient nutritional supplement is provided that is designed to be most effective in optimizing health, increasing the immunity and decreasing the instances and severity of infection particularly among children.Type: GrantFiled: August 23, 2002Date of Patent: May 20, 2003Assignee: Tsar Health Private Ltd.Inventor: Ranjit Kumar Chandra
-
Patent number: 6562378Abstract: A multinutrient nutritional supplement is provided that is designed to be most effective in optimizing health, increasing the immunity and decreasing the instances and severity of infection particularly among adolescents.Type: GrantFiled: August 16, 2002Date of Patent: May 13, 2003Assignee: TSAR Health Private Ltd.Inventor: Renjit Kumar Chandra
-
Patent number: 6541421Abstract: This invention relates to a buffered phosphorus containing solution comprising at least one phosphorus compound selected from the group consisting of phosphorous acid, hypophosphorous acid, polyphosphorous acid polyhypophosphorous acid, and salts thereof. The solution also contains a buffer including an organic base in the form of a nitrogen containing compound and its conjugate acid. The solution may be used as a fertilizer or as a fungicide. The invention also relates to a method of preparing such a solution.Type: GrantFiled: October 4, 2000Date of Patent: April 1, 2003Inventors: Alastair James Forsyth, Tomasz Antoni Modro
-
Patent number: 6538038Abstract: Treatment of warm-blooded animals having a tumor or non-malignant hypervascularation, by administering a sufficient amount of a cytotoxic agent formulated into a phosphate prodrug form having substrate specificity for microvessel phosphatases, so that microvessels are destroyed preferentially over other normal tissues, because the less cytotoxic prodrug form is converted to the highly cytotoxic dephosphorylated form.Type: GrantFiled: February 16, 2000Date of Patent: March 25, 2003Assignee: OXiGENE, Inc.Inventors: Ronald W. Pero, David Sherris
-
Publication number: 20030049330Abstract: Polyoxometalate topical compositions for removing contaminants from an environment and methods of use thereof are disclosed. An emobodiment of the polyoxometalate topical composition includes a topical carrier and at least one polyoxometalate, with the proviso that the polyoxometalate is not H5PV2Mo10O40; K5Si(H2O)MnIIIW11O39; K4Si(H2O)MnIIIW11O39; or K5CoIIIW12O40. Another embodiment relates to a method for removing a contaminant from an environment, including contacting the polyoxometalate topical composition with the environment containing the contaminant for a sufficient time to remove the contaminant from the environment.Type: ApplicationFiled: April 29, 2002Publication date: March 13, 2003Inventors: Craig L. Hill, Ling Xu, Jeffrey T. Rhule, Eric A. Boring
-
Patent number: 6528051Abstract: The methods and compositions of the present invention are directed to enhancing an immune response and increasing vaccine efficacy through the simultaneous or sequential targeting of specific immune system components. More particularly, specific immune components, such as macrophages, dendritic cells, B cells and T cells, are individually activated by component-specific immunostimulating agents. One such component-specific immunostimulating agent is an antigen-specific, species-specific monoclonal antibody. The invention is also directed to a method for the in vitro production of the antigen-specific, species-specific monoclonal antibodies which relies upon the in vitro conversion of blood-borne immune cells, such as macrophages and lymphocytes. Vaccine efficacy is enhanced by the administration of compositions containing component-specific immunostimulating agents and other elements, such as antigens or carrier particles, such as colloidal methods, such as gold.Type: GrantFiled: August 22, 2001Date of Patent: March 4, 2003Assignee: CytImmune Sciences, Inc.Inventors: Lawrence Tamarkin, Giulio F. Paciotti
-
Patent number: 6521264Abstract: A solid powder product with a Ca/P ratio of between 1.40 and 1.90 is prepared from tricalcium phosphate and tetracalcium phosphate. An aqueous solution containing calcium ions and phosphate ions with a Ca/P ratio higher than 0.20 and lower than 0.50 is prepared. The aqueous solution and the solid powder product and optionally water are mixed to obtain a mixture with a liquid/solid weight ratio of between 0.30 and 0.65 and a resulting paste with a Ca/P ratio of between 1.50 and 1.67.Type: GrantFiled: January 11, 2000Date of Patent: February 18, 2003Assignee: TeknimedInventors: Jean-Louis Lacout, Zinèb Hatim, Michele Frache-Botton
-
Patent number: 6517848Abstract: Methods of using absorbent personal care articles, such a diapers and adult incontinent briefs, comprising an absorbent article and having disposed thereon a skin irritant sequestering effective amount of an unmodified particulate skin irritant sequestering agent, and a lipophilic skin health benefit agent are provided. An unmodified particulate skin irritant sequestering agent can be a clay, such as bentonite or laponite unmodified by organic amphiphilic compounds. A lipophilic skin health benefit agent can be stearic acid, isoparrafin, petrolatum, and a combination thereof. The skin irritant can be bound to the sequestering agent either on an individual's skin or on the absorbent article.Type: GrantFiled: December 30, 1999Date of Patent: February 11, 2003Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Linda Susan Huard, David John Tyrrell, David Roland Otts, Bernard Joseph Minerath, III, Brenda Marie Nelson, Chantel Spring Buhrow, Dennis Stein Everhart, Robert Cosmo DiLuccio, Frank Jerrel Akin
-
Patent number: 6506394Abstract: The present invention relates to a combination for surface treatment of a substrate, e.g. a nonwoven web, used in personal care product applications. The surface treatment combination not only provides adequate fluid handling properties, but also provides a topical delivery system effective in depositing a thin, tenacious and substantially continuous coating of a botanical extract on skin by an aqueous emulsion mediated dissolution of the agent from a substrate with subsequent transfer and deposition onto the skin. Coatings of the botanical extract on the skin resist removal, thereby preventing damage to the natural skin barrier and providing a protective barrier against chemically- and biochemically-induced skin damage.Type: GrantFiled: May 12, 2000Date of Patent: January 14, 2003Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Ali Yahiaoui, Dennis Stein Everhart, Wade Bolton May
-
Patent number: 6485733Abstract: Absorbent personal care articles, such a diapers and adult incontinent briefs, are provided comprising an absorbent article and having disposed thereon a skin irritant sequestering effective amount of an unmodified particulate skin irritant sequestering agent, and a lipophilic skin health benefit agent. An unmodified particulate skin irritant sequestering agent can be a clay, such as bentonite or laponite unmodified by organic amphiphilic compounds. A lipophilic skin health benefit agent can be stearic acid, isoparrafin, petrolatum, and a combination thereof. The skin irritant can be bound to the sequestering agent either on an individual's skin or on the absorbent article.Type: GrantFiled: December 30, 1999Date of Patent: November 26, 2002Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Linda Susan Huard, David John Tyrrell, David Roland Otts, Bernard Joseph Minerath, III, Brenda Marie Nelson, Chantel Spring Buhrow, Dennis Stein Everhart, Robert Cosmo DiLuccio, Frank Jerrel Akin
-
Patent number: 6475631Abstract: The present invention provides an antimicrobial agent consisting of glass which comprises 50 to 60 mole % of ZnO, 20 to 30 mole % of at least one member selected from the group consisting of B2O3 and P2O5, 1 to 10 mole % of at least one member selected from the group consisting of Al2O3 and ZrO2, 5 to 10 mole % of an alkali metal oxide and 0 to 15 mole % of SiO2 and an antimicrobial agent consisting of glass which comprises 50 to 70 mole % of ZnO, 20 to 35 mole % of P2O5, 0.5 to 10 mole % of Al2O3, 0.5 to 10 mole % of SnO2, 0 to 5 mole % of SiO2 and 5 to 10 mole % of an alkali metal oxide as well as an antimicrobial resin composition and antimicrobial artificial marble, each of which comprises a resin and the antimicrobial agent blended therewith. The antimicrobial resin composition and the antimicrobial artificial marble are excellent in their antimicrobial properties, resistance to color change and water resistance.Type: GrantFiled: July 14, 2000Date of Patent: November 5, 2002Assignee: Toagosei Co., Ltd.Inventors: Noriyuki Yamamoto, Koji Sugiura, Satoshi Yamato
-
Publication number: 20020160054Abstract: A composition for controlling growth of pathological organisms on a plant, said composition comprises an effective amount of one or more of metal ion(s); one or more of chelating agent(s); and phosphorous acid, and/or salt or hydrate thereof, said composition is in an agriculturally compatible carrier or vehicle.Type: ApplicationFiled: January 29, 2002Publication date: October 31, 2002Inventor: Ran Lifshitz
-
Publication number: 20020110600Abstract: A composition for relief of symptoms of colds and influenza, containing, by weight, about 80-88% olive leaf extract powder containing oleuropein, about 5-10% neem leaf powder and up to about 8% of a homeopathic blend for symptom relief which preferably comprises aconitum napelius, belladonna, eupatorium perfoliatum, gelsemium sempervirens, Echinacea angustifolia and ferrum phosphoricum.Type: ApplicationFiled: February 15, 2001Publication date: August 15, 2002Inventors: John Voorhees, Leslie Nachman
-
Publication number: 20020102893Abstract: Polyurethane elastomer yarns (particularly spandex) containing certain silver-based antimicrobial formulations therein are provided. This invention relates to polyurethane elastomer yarns (particularly spandex) containing certain silver-based antimicrobial formulations therein. Such formulations comprise antimicrobial compounds, such as, preferably, triclosan and/or silver-containing ion-exchange resins, such as zirconium phosphate, glass, and/or zeolite compounds. The inventive spandex yarns exhibit excellent antimicrobial qualities as well as surprisingly good anti-tack/frictional characteristics. As a result, antimicrobial spandex yarns are provided which exhibit ease in processing, particularly in further knitting, weaving, etc., to produce fabrics therefrom. Such fabrics are also encompassed within this invention.Type: ApplicationFiled: December 4, 2000Publication date: August 1, 2002Inventors: Randy D. Petrea, Robert L. Schuette, Leland G. Close, Shirley Anne Whiteside
-
Patent number: 6420591Abstract: The present invention relates to novel carbamates and pharmaceutically acceptable salts thereof; compositions comprising the carbamate or a pharmaceutically acceptable salt thereof; and methods for treating cancer, inflammation, or a viral infection comprising administering to a patient in need of such treatment a therapeutically effective amount of the carbamate or pharmaceutically acceptable salt thereof.Type: GrantFiled: October 4, 2000Date of Patent: July 16, 2002Assignee: University of Medicine and Dentistry of New JerseyInventors: Tariq M Rana, Seongwoo Hwang, Natarajan Tamilarasu
-
Patent number: 6355277Abstract: There is disclosed a method of improving the smoke suppressant characteristics of halogen-containing polymeric compositions which comprises adding to said polymeric compositions a smoke retardant amount of (1) a complex of a cuprous halide and a phosphite, and (2) an amine molybdate which contains no residual molybdenum trioxide prepared by reacting an amine with molybdenum trioxide in an aqueous acidic medium under greater than atmospheric pressure and at a temperature of from 105-150° C.Type: GrantFiled: July 14, 2000Date of Patent: March 12, 2002Assignee: Unitex Chemical CorporationInventors: James F. Day, Chad E. Lee
-
Patent number: 6352706Abstract: An ingestible mollusc poison contains a simple metal compound, an activity enhancing additive such as ethylene diamine disuccinic acid (EDDS) and derivatives thereof, and a carrier material edible to molluscs. In one embodiment the active agent of the mollusc poison may be in the form of a metal complex of EDDS. The composition may be used alone or in conjunction with molluscicidal co-active agents and/or fertilizers.Type: GrantFiled: February 1, 1999Date of Patent: March 5, 2002Assignee: W. Neudorff GmbH KGInventor: George S. Puritch
-
Patent number: 6350474Abstract: The invention deals with phosphate water solution with cold solidification capacity. Phosphate composition containing iron oxide solution in acid, water, advantages from the following properties; it contains orthophosphorus acid and in addition metal powder. Phosphate composition is ecologically pure product, non toxic, non cancerogenic, non-allergic. It has antimicrobial, antivirus and fungicidal properties. Phosphate composition can be applied within medicine: surgery, dermatology, dentistry, oncology, pharmacology and other branches. In agriculture use: as a means of curing plant diseases, within veterinary—as a means for preventive maintenance and curing of animal diseases, within construction—as an anticorrosive, fire-resistant, hydro-electric isolating covers, ceramic tiles, concretes, which protect against radiation, as well as for producing other composite materials.Type: GrantFiled: June 7, 1999Date of Patent: February 26, 2002Inventors: David Dzneladze, Andro Dzneladze, Nargisa Jabishvili
-
Patent number: 6346279Abstract: An acidic aqueous hydrogen peroxid solution is provided, with improved disinfectant activity. Concentrated solutions preferably contain up to about 8% and as-used concentrations contain about 0.5% peroxide. The solution also contains from 0.1 to 5.0% of at least one acid compound, e.g. phosphoric and/or a phosphonate with from 1 to 5 phosphonic acid groups, and from 0.02 to 5% of at least one anionic surfactant. The surfactant is selected from C8 to C16-alkyl aryl sulphonic acids, sulphonated C12 to C22 carboxylic acids, C8 to C22-alkyl diphenyl oxide sulphonic acids, naphthalene sulphonic acids, C8 to C22 alkyl sulphonic acids, and alkali metal and ammonium salts thereof, and alkali metal C8 to C18 alkyl sulphates, and mixtures thereof. Most preferably the solution has an emulsifier, e.g. a salt of an alkylated diphenyl oxide. The solution may also contain corrosion inhibitors and/or lower alcohols.Type: GrantFiled: July 19, 1999Date of Patent: February 12, 2002Assignee: Virox Technologies, Inc.Inventor: Michael J. Rochon
-
Publication number: 20020015741Abstract: A composition for accelerating the disposal of ethanol from bodily fluid. Certain additives can accelerate the metabolic oxidation of ethanol, and others in addition act as catalysts or “pseudo” enzymes for the oxidation. Additives include the oxidant Nicotinamide Adenine Dinucleotide and a variety of other additives such as transition metal ions and complexes thereof which favor the oxidation reaction. The compositions described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.Type: ApplicationFiled: June 7, 2001Publication date: February 7, 2002Inventors: Ward Beryl Bowen, Daniel Salman Daniel
-
Patent number: 6303155Abstract: A method for restoration of the circadian rhythm of parathyroid hormone (PTH) serum levels in a subject having osteoporosis, so as to restore a circadian rhythm of PTH levels which is similar to that existing in normal subjects is disclosed by administering a single daily dose of a composition consisting essentially of an effective amount of phosphate in the evening or at night, whereby the composition causes a circadian rhythm of PTH levels which peaks during the night, whereby the circadian rhythm of PTH levels is restored to that which is similar to that existing in normal subjects, thereby treating osteoporosis.Type: GrantFiled: March 1, 1999Date of Patent: October 16, 2001Assignee: Hadasit Medical Research Services and Development Company, Ltd.Inventor: Justin Silver
-
Patent number: 6277414Abstract: The present invention relates to an aqueous decontaminating composition comprising (A) an amount of H2O2 less than or equal to 60% by weight, based on the total weight of said composition; (B) an RCO3H/RCO2H mixture, where R is methyl or ethyl, as indicated above, said mixture being present in an amount such that the weight ratio of said mixture to the hydrogen peroxide is between 0.15/1 and 0.85/1; (C) a silver component as a source of Ag ions, selected from the group consisting of silver salts and complexes, said silver component being present in an amount such that the weight ratio of said silver component to the hydrogen peroxide is between 0.0005/1 and 0.015/1; (D) a stabilizer present in an amount such that the weight ratio of said stabilizer to the hydrogen peroxide is between 0.0005/1 and 0.025/1; and water to make up to 100% by weight. It further relates to the method of preparation and to the use of said composition.Type: GrantFiled: September 22, 1998Date of Patent: August 21, 2001Assignee: SodifraInventors: Alain Elhaik, Raphaël Alex De Nicola