Heavy Metal Containing Patents (Class 424/604)
  • Patent number: 6921544
    Abstract: A stable, phase-pure magnesium-substituted crystalline hydroxyapatite containing from about 2.0 to about 29 wt % magnesium, wherein at least 75 wt % of the magnesium content is substituted for calcium ions in the hydroxyapatite lattice structure.
    Type: Grant
    Filed: March 6, 2001
    Date of Patent: July 26, 2005
    Assignee: Rutgers, The State University
    Inventors: Richard E. Riman, Wojciech Suchanek, Pavel Shuk, Kevor S. TenHuisen
  • Patent number: 6911470
    Abstract: Polyoxometalate compounds which exhibit anti-retroviral activity are disclosed. Compounds with anti-retroviral activity include those having the following general molecular formulas: M7PW11O39 M8SiW11O39 M9HSiW9O34 M8HPW9O34 M10(TM)4(PW9O34)2 M16(TM)4(P2W15O56)2 M14[NaP5W30O110] M12(TM)3(PW9O34)2 M6P2W18O62 wherein M is an alkali metal, NH4+ or other common monocation or soluble dication, or any combination of the above provided adequate water solubility is exhibited, or histidinium ion, argininium ion, or lysinium ion or any dication of a dipeptide or oligopeptide with 2 protonated basic amino acid residues, or any combination of these monocations or dications with each other or with any common inorganic cation, and TM is a divalent transition metal ion, such as Mn, Fe, Co, Ni, Cu and Zn.
    Type: Grant
    Filed: October 25, 1993
    Date of Patent: June 28, 2005
    Inventors: Raymond F. Schinazi, Craig L. Hill
  • Patent number: 6881424
    Abstract: A highly acidic metalated organic acid composition and its preparation. The acidic composition can be prepared by mixing a monovalent or polyvalent cation and an organic acid in the presence of a strong oxyacid, wherein the resultant acidic composition is less corrosive to a ferrous metal than a solution of a mineral acid having the same acidic pH value as that of the acidic composition, and where in the acid composition is more biocidal than a mixture of the organic acid and a metal salt of the organic acid which mixture has the same acid normality value as that of the acidic composition. The acidic composition can be prepared by mixing at least one regenerating acid, at least one metal base, and at least one organic acid, wherein the amount of the regenerating acid is in excess of the equivalent amount of the metal base.
    Type: Grant
    Filed: September 5, 2000
    Date of Patent: April 19, 2005
    Assignee: Mionix Corporation
    Inventors: Maurice Clarence Kemp, Robert Blaine Lalum, David E. Lewis, Robert H. Carpenter
  • Patent number: 6855341
    Abstract: Disclosed are anti-viral compositions containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients), and a pharmaceutical carrier. Also disclosed are methods of treating lesionous symptoms of a viral infection involving applying an effective amount of the anti-viral composition to the lesions.
    Type: Grant
    Filed: November 4, 2002
    Date of Patent: February 15, 2005
    Inventor: Jeffrey B. Smith
  • Patent number: 6849276
    Abstract: The invention concerns a phytosanitary fungicide, bactericidal or bacteriostatic composition comprising at least a mineral salt, a copper oxide or hydroxide suspended in an aqueous emulsion of at least a terpene derivative.
    Type: Grant
    Filed: August 24, 1999
    Date of Patent: February 1, 2005
    Assignee: Action Pin
    Inventors: Ghislain Dufau, Michel Barsacq, Gérard Molla
  • Patent number: 6833362
    Abstract: A composition for accelerating the disposal of ethanol from bodily fluid. Certain additives can accelerate the metabolic oxidation of ethanol, and others in addition act as catalysts or “pseudo” enzymes for the oxidation. Additives include the oxidant Nicotinamide Adenine Dinucleotide and a variety of other additives such as transition metal ions and complexes thereof which favor the oxidation reaction. The compositions described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.
    Type: Grant
    Filed: June 7, 2001
    Date of Patent: December 21, 2004
    Inventors: Ward Beryl Bowen, Jr., Daniel Salman Daniel
  • Publication number: 20040241251
    Abstract: Random or block co- or terpolymers produced by using metal complex catalysts in a reaction of one conjugated diene monomer with one aromatic Random or block co- or terpolymers produced by using metomers with one aromatic &agr;-olefin or terpolymers of one conjugated diene monomer with one aromatic &agr;-olefin and one aliphatic &agr;-olefin by using metal complexes comprising metals of group 3 to 10 of the Periodic System of the Elements in combination with activators and optionally a support material. More particularly the metal complexes used for the synthesis of co- or terpolymer are lanthanide metals. Even more particularly diene monomer(s) and aromatic &agr;-olefin monomer(s) such as, but not limited to, butadiene and styrene or isoprene and styrene are copolymerized giving random or block copolymers or butadiene, styrene and isoprene are terpolymerized giving random or block terpolymers using metal complexes comprising lanthanide metals in combination with activators and optionally a support material.
    Type: Application
    Filed: October 3, 2003
    Publication date: December 2, 2004
    Inventors: Sven K H Thiele, Victor M. Monroy, David R. Wilson
  • Patent number: 6824794
    Abstract: A water treatment agent and method of treating water to inhibit, reduce, or prevent the formation of algae and bacteria in a water body. The water treatment agent may include copper sulfate penta-hydrate and/or silver, di-sodium ethylene di-amine tetra-acetic acid dihydrate, a scale inhibitor, a shocking agent and a buffer agent. For instance, the treatment agent may include a composition of copper sulfate pentahydrate, di-sodium ethylene di-amine tetra-acetic acid, monopotassium phosphate or sulfuric acid, and potassium monopersulfate and 1-hydroxyethylidene-1,1-diphosphonic acid.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: November 30, 2004
    Assignee: Innovative Water Technologies, Inc.
    Inventors: Terry A. Ring, Tom Smolkov, M. Anthony Gamarra
  • Publication number: 20040228880
    Abstract: The present invention relates to vaccine compositions comprising iron phosphate as adjuvant. This iron phosphate is in the form of particles, the size of which is between 0.01 &mgr;m and 300 &mgr;m; it can be obtained by mixing a solution of iron salt and of phosphate salt.
    Type: Application
    Filed: May 14, 2004
    Publication date: November 18, 2004
    Applicant: Aventis Pasteur SA
    Inventor: Elisabeth Sauzeat
  • Publication number: 20040228794
    Abstract: Disclosed herein are therapeutic agent carrier compositions that include a carrier comprised of a stimulus sensitive gel, fibrin, or combinations thereof, and a therapeutic agent such as an aqueous insoluble or confined radioisotope. Stimulus sensitive gels include thermally reversible stimulus-sensitive gels that are linear random copolymers of a [meth-]acrylamide derivative and a hydrophilic comonomer; thermogelling biodegradable polymers, which include biodegradable polymers including a linked polyethylene glycol (PEG) block and biodegradable polyester block; and enzymatically degradable polypeptide poylmers. In certain embodiments the therapeutic agent is a hydrothermally synthesized radioactive therapeutic agent, such a 90-yttrium phosphate colloid. Methods of making such carrier compositions and methods of using such carrier compositions to treat diseases such as cancer also are disclosed.
    Type: Application
    Filed: February 19, 2004
    Publication date: November 18, 2004
    Applicant: Battelle Memorial Institute
    Inventors: Richard E. Weller, Darrell R. Fisher, Michael A. Lind, Allison A. Campbell, Anna Gutowska, Craig F. Habeger
  • Patent number: 6803057
    Abstract: An acidic aqueous hydrogen peroxide solution is provided with improved disinfectant activity. Concentrated solutions preferably contain up to about 8 wt./wt. % H2O2 and as-used concentrations contain about 0.5% wt./wt. % H2O2. The solution also contains from 0.05 to 8.0 wt./wt. % of at least one phosphorous-based acid, e.g. phosphoric acid and/or a phosphonic acid with from 1 to 5 phosphonic acid groups, and from 0.02 to 5 wt./wt. % of at least one anionic surfactant. The surfactant is selected from C8 to C16 alkyl aryl sulfonic acids, sulfonated C12 to C22 carboxylic acids, C8 to C22 alkyl diphenyl oxide sulfonic acids, naphthalene sulfonic acids, C8 to C22 alkyl sulfonic acids, and alkali metal and ammonium salts thereof, and alkali metal C8 to C18 alkyl sulfates, and mixtures thereof. Most preferably the solution has an emulsifier and/or hydrotrope, e.g. an alkylated sulfonated diphenyl oxide salt, an alkyl aryl polyoxyethylene surfactant, and/or a polyoxyethylene surfactant.
    Type: Grant
    Filed: December 28, 2001
    Date of Patent: October 12, 2004
    Assignee: Virox Technologies Inc.
    Inventors: Jose A. Ramirez, Michael J. Rochon
  • Publication number: 20040180098
    Abstract: Improved powder coatings exhibit enhanced resistance to bacterial and fungal attack, while possessing excellent toughness, appearance, corrosion resistance, durability, processability, and ease of application. The coating is comprised of anti-microbial agents that are homogeneously dispersed within the powder or impact fused to powder particles or both. An article may be coated with a thermoset thermoplastic, or radiation curable powder, which may be applied by electrostatic spray or fluidized bed or by thermal or flame spray.
    Type: Application
    Filed: March 24, 2004
    Publication date: September 16, 2004
    Inventors: Owen H. Decker, Michael A. Sparks, Jeffrey R. Hagerlin, Frederick L. Cummings, Peter Gottschling
  • Publication number: 20040175431
    Abstract: A method of administering iron to dialysis patients is accomplished by infusion of a noncolloidal ferric compound, soluble in hemodialysis or peritoneal dialysis solutions, by the process of dialysis. A pharmaceutical composition is provided consisting essentially of dialysis solution including a soluble noncolloidal ferric compound, preferably ferric pyrophosphate.
    Type: Application
    Filed: March 9, 2004
    Publication date: September 9, 2004
    Inventor: Ajay Gupta
  • Publication number: 20040170700
    Abstract: The present invention provides an antibacterial glass composition exhibiting high antibacterial performance with sufficiently sustaining antibacterial performance by adding a small amount of the antibacterial component, and an antibacterial polymer composition using the antibacterial glass composition. The present invention provides an antibacterial glass composition containing 0.1 to 5.0% by weight of Ag2O in a glass composition containing 30 to 60 mol % of P2O5, 1 to 15 mol % of one or more compounds selected from the group consisting of K2O, Na2O and Li2O, 35 to 55 mol % of one or more compounds selected from the group consisting of MgO, CaO and ZnO, and 0.01 to 3 mol % of one or more compounds selected from the group consisting of La2O3 and Y2O3.
    Type: Application
    Filed: November 26, 2003
    Publication date: September 2, 2004
    Applicant: ISHIZUKA GARASU KABUSHIKI KAISHA
    Inventors: Minoru Numaguchi, Makio Nomura
  • Patent number: 6764692
    Abstract: A method of treating laminitis in a horse is disclosed, comprising administering to the horse a naturally chelated trace mineral composition; promoting healthy skin, hair and hoof tissue. A method of reducing dietary intake is also disclosed, comprising administering to a horse in need thereof, effective amounts of a naturally chelated trace mineral composition. A method of preparing the chelated trace mineral composition from ocean seabed rock is further disclosed, as well as the chelated trace mineral composition.
    Type: Grant
    Filed: August 27, 2002
    Date of Patent: July 20, 2004
    Inventor: Carlos Cortelezzi
  • Patent number: 6761912
    Abstract: A composition and a method for administering an improved supplement to prevent bone density loss. The composition combines a calcium compound with inulin, and optionally magnesium, Vitamin D3, Vitamin K, Vitamin C, and may combine a soy isoflavone, all in a dietary acceptable form in a beverage, a beverage preparation, a paste, a bar, or a cookie.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: July 13, 2004
    Assignee: Pharmavite LLC
    Inventors: Samuel L. Forusz, Hanlan Liu, Rose M. Muatine
  • Patent number: 6753016
    Abstract: A method for the protection of wood and other wood materials without affecting dimensional stability or surface integrity of the treated material is described. The method involves treating wood material with an iron salt and selected oxidants where the iron salt is preferably complexed with organic chelating ligands. Preferably, a microbicidal agent is also incorporated into the method to provide treated wood products that demonstrate excellent surface integrity, dimensional stability and retention of the infused microbicidal agents for extended periods of time without incurring the detrimental environmental effects of conventional chromium or copper-based inorganic salt preservation methods.
    Type: Grant
    Filed: June 6, 2002
    Date of Patent: June 22, 2004
    Assignee: Rohm and Haas Company
    Inventor: Tirthankar Ghosh
  • Patent number: 6723349
    Abstract: The invention relates to a polyoxometalate topical composition for removing a contaminant from an environment, comprising a topical carrier and at least one polyoxometalate, with the proviso that the polyoxometalate is not H5PV2Mo10O40; K5Si(H2O)MnIIIW11O39; K4Si(H2O)MnIVW11O39; or K5CoIIIW12O40. The invention further relates to a method for removing a contaminant from an environment, comprising contacting the polyoxometalate topical composition of the present invention with the environment containing the contaminant for a sufficient time to remove the contaminant from the environment. The invention further relates to a modified polyoxometalate, wherein the modified polyoxometalate comprises the admixture of (1) a polyoxometalate and (2) a cerium compound, a silver compound, a gold compound, a platinum compound, or a combination thereof.
    Type: Grant
    Filed: October 11, 2000
    Date of Patent: April 20, 2004
    Assignee: Emory University
    Inventors: Craig L. Hill, Ling Xu, Jeffrey T. Rhule, Eric A. Boring
  • Patent number: 6723350
    Abstract: The invention provides methods and kits to form water swellable gel coatings, preferably lubricious coatings, on substrates, and coated substrates thus formed. The coatings contain one or more antimicrobial metals formed with atomic disorder, together with one or more antimicrobial metals formed with atomic disorder such that the coatings provide an antimicrobial and anti-inflammatory effect when wet. The invention also provides a method to produce metal powders by sputtering a coating onto a moving surface, and then scraping the coating with one or more scrapers to produce the metal powder. The method is particularly useful for producing large amounts of nanocrystalline antimicrobial metal powders formed with atomic disorder, useful in the water swellable gel coatings of this invention.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: April 20, 2004
    Assignee: Nucryst Pharmaceuticals Corp.
    Inventors: Robert Edward Burrell, Hua Qing Yin, Antony George Naylor, Peter Howard Moxham, Walter Carlton Theodore Cholowski, Leonard Salvin Bowlby, David James Field
  • Patent number: 6713076
    Abstract: The invention relates to a method for removing a contaminant from a gas phase or a liquid phase by contacting an article composed of (1) a fabric or cellulosic fiber and (2) a polyoxometalate, wherein the polyoxometalate is incorporated in the fabric or cellulosic fiber, with the gas phase or liquid phase containing the contaminant. The invention further relates to a polyoxometalate-modified fabric composed of a fabric and a polyoxometalate of the present invention incorporated in the fabric. The invention further relates to an article containing the polyoxometalate-modified fabric. The invention further relates to a method for making the polyoxometalate-modified fabric, by contacting the fabric with a polyoxometalate to produce a polyoxometalate-modified fabric.
    Type: Grant
    Filed: December 4, 2000
    Date of Patent: March 30, 2004
    Assignee: Emory University
    Inventors: Craig L. Hill, Ling Xu
  • Publication number: 20040058011
    Abstract: A non-toxic, germicide, fungicide and healing composition and a method of topically applying the composition in powdered form to the skin of domesticated farm animals including dairy cattle are disclosed. The composition comprises (a) finely divided, particulate chlorhexidine-containing material, (b) finely divided, particulate zinc-containing material and (c) an inert powdered carrier, with the chlorhexidine-containing material and the zinc-containing material being present in an amount to achieve effective germicidal activity. The chlorhexidine-containing material is preferably chlorhexidine acetate. The zinc-containing material is preferably selected from the group consisting of zinc stearate, zinc chloride, zinc nitrate, zinc oleate, zinc oxide, zinc phosphate, zinc peroxide, zinc iodide, elemental zinc and mixtures thereof.
    Type: Application
    Filed: September 10, 2003
    Publication date: March 25, 2004
    Inventor: Lennart G. Petersson
  • Patent number: 6706683
    Abstract: A method of controlling granule secretion comprising performing a treatment to increase or decrease an active form of calgranulin on a cell line having capability of secreting granules, thereby increasing or decreasing granule secretion from the cell line. A method of detecting a substance which inhibits or activates the granule secretion reaction by applying this controlling method. An active form of calgranulin is increased by making the cells permeabilized cells and adding a calgranulin and soluble calcium. Decrease of an active form of calgranulin is carried out by introducing a calgranulin antibody into cells. The method is useful for screening a substance which inhibits or activates granule secretion.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: March 16, 2004
    Assignee: Asahi Kasei Pharma Corporation
    Inventors: Minoru Seto, Kouichirou Fukuda
  • Patent number: 6689392
    Abstract: A composition for controlling growth of pathological organisms on a plant, said composition comprises an effective amount of one or more of metal ion(s); one or more of chelating agent(s); and phosphorous acid, and/or salt or hydrate thereof, said composition is in an agriculturally compatible carrier or vehicle.
    Type: Grant
    Filed: January 29, 2002
    Date of Patent: February 10, 2004
    Assignee: Agricare Ltd.
    Inventor: Ran Lifshitz
  • Patent number: 6660289
    Abstract: The invention concerns an oxidising aqueous composition useful in particular for disinfection, hygiene and depollution purposes, and for surface treatment (particularly a metal surface to be stripped and/or passivated), and said composition, containing in water hydrogen peroxide, a RCO2H/RCO3H mixture (wherein R is a C1-C6 aliphatic radical with linear or branched hydrocarbon chain, saturated or unsaturated), a stabilising agent which is an acid and, as the case may be, Ag+ ions. The invention is characterised in that it contains ions of at least one metal M which are ions of AgII, AgIII, VV, NbV, TaV, MoVI, WVI, CoIII, InIII or TlIII. Advantageously, said composition can be in gel form. The invention also concerns the method for preparing said composition.
    Type: Grant
    Filed: October 23, 2001
    Date of Patent: December 9, 2003
    Assignee: Digol International LTD
    Inventors: Rémi Wilmotte, Bernard Lebeau, Jean-Pierre Irurzun, Françoise Marechal
  • Publication number: 20030215521
    Abstract: Improvements in increasing the amount of surface-available silver in thermoplastic articles comprising certain silver-containing antimicrobial agents. Such an invention requires the incorporation of a sufficient amount of a carboxylic acid salt within the thermoplastic article simultaneously with the necessary silver-containing antimicrobial agent. Certain carboxylic acid salts are standard acid scavengers and lubricants for certain thermoplastic applications; however, the amounts required within this inventive thermoplastic article are in excess of that commonly added within such articles, and the types of acid scavengers possibly added within such target thermoplastic articles are preferably neutralized hydrotalcite compounds, thereby permitting the carboxylic acid salt to function in the inventive manner.
    Type: Application
    Filed: June 4, 2003
    Publication date: November 20, 2003
    Inventors: Erik Laridon, Geoffrey Haas, Robert Dankel
  • Publication number: 20030118658
    Abstract: The invention relates to a high aspect ratio microcapsule comprising an inorganic antimicrobial agent coated with a hydrophilic polymer. The hydrophilic polymer is able to absorb sufficient water as to enable the action of the encapsulated antimicrobial agent. These high aspect ratio microcapsules are useful to impart antimicrobial activity and can be used in polymer compositions, sprays and coatings. A method of preparing the high aspect ratio microcapsule by melt compounding and fabrication of the antimicrobial agent with the hydrophilic polymer is provided. Polymer compositions comprising the high aspect ratio microcapsules and a matrix polymer are also provided. Another embodiment of the invention is an article prepared from the polymer compositions comprising the high aspect ratio microcapsules and a matrix polymer.
    Type: Application
    Filed: December 21, 2001
    Publication date: June 26, 2003
    Inventors: Jeffrey A. Trogolo, Frank C. Rossitto, Edward K. Welch
  • Patent number: 6582719
    Abstract: The present invention relates to compositions comprising a combination of one or more antiseptic and an antibiotic. It is based, at least in part, on the discovery that such combinations tend to deter the formation of antibiotic-resistant organisms. In preferred, nonlimiting embodiments of the invention, the antibiotic is minocycline and the antiseptic is a chlorhexidine compound, triclosan, or benzalkonium chloride, and in particular embodiments, a silver salt or a bismuth salt is added. Examples of specific, nonlimiting embodiments of the invention include combinations of (i) minocycline, triclosan, and a bismuth salt; (ii) minocycline, a chlorhexidine compound, and a bismuth salt; and (iii) minocycline, benzalkonium chloride, and a bismuth salt. The present invention further provides for articles, such as, but not limited to, medical articles, which have been treated with or which otherwise comprise a combination of antiseptic and antibiotic.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: June 24, 2003
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Shanta M. Modak, Suhas Tambe, Lester A. Sampath
  • Patent number: 6565892
    Abstract: Synergistic fungicidal composition comprising a compound analogous to strobilurin of formula (I): in which: A is the nitrogen atom or the —CH group, B is the —OCH2— or —CH2O— or CH(CH3)—O—N═CH— or —CH═N—O—CH(CH3)— group or the group R1 is an alkyl group containing 1 to 4 carbon atoms, R2 is —OCH3 or —NHCH3, X is a halogen atom, the cyano group or an alkyl or haloalkyl group containing 1 to 4 carbon atoms, n is equal to 1 or 2, with, when n is equal to 2, the possibility of having different X groups, and at least one fungicidal compound B, and a process for the curative or preventive control of phytopathogenic fungi using the composition.
    Type: Grant
    Filed: July 3, 2001
    Date of Patent: May 20, 2003
    Assignee: Rhone-Poulenc Agrochimie
    Inventor: Patrice Duvert
  • Patent number: 6565891
    Abstract: A multinutrient nutritional supplement is provided that is designed to be most effective in optimizing health, increasing the immunity and decreasing the instances and severity of infection particularly among children.
    Type: Grant
    Filed: August 23, 2002
    Date of Patent: May 20, 2003
    Assignee: Tsar Health Private Ltd.
    Inventor: Ranjit Kumar Chandra
  • Patent number: 6562378
    Abstract: A multinutrient nutritional supplement is provided that is designed to be most effective in optimizing health, increasing the immunity and decreasing the instances and severity of infection particularly among adolescents.
    Type: Grant
    Filed: August 16, 2002
    Date of Patent: May 13, 2003
    Assignee: TSAR Health Private Ltd.
    Inventor: Renjit Kumar Chandra
  • Patent number: 6541421
    Abstract: This invention relates to a buffered phosphorus containing solution comprising at least one phosphorus compound selected from the group consisting of phosphorous acid, hypophosphorous acid, polyphosphorous acid polyhypophosphorous acid, and salts thereof. The solution also contains a buffer including an organic base in the form of a nitrogen containing compound and its conjugate acid. The solution may be used as a fertilizer or as a fungicide. The invention also relates to a method of preparing such a solution.
    Type: Grant
    Filed: October 4, 2000
    Date of Patent: April 1, 2003
    Inventors: Alastair James Forsyth, Tomasz Antoni Modro
  • Patent number: 6538038
    Abstract: Treatment of warm-blooded animals having a tumor or non-malignant hypervascularation, by administering a sufficient amount of a cytotoxic agent formulated into a phosphate prodrug form having substrate specificity for microvessel phosphatases, so that microvessels are destroyed preferentially over other normal tissues, because the less cytotoxic prodrug form is converted to the highly cytotoxic dephosphorylated form.
    Type: Grant
    Filed: February 16, 2000
    Date of Patent: March 25, 2003
    Assignee: OXiGENE, Inc.
    Inventors: Ronald W. Pero, David Sherris
  • Publication number: 20030049330
    Abstract: Polyoxometalate topical compositions for removing contaminants from an environment and methods of use thereof are disclosed. An emobodiment of the polyoxometalate topical composition includes a topical carrier and at least one polyoxometalate, with the proviso that the polyoxometalate is not H5PV2Mo10O40; K5Si(H2O)MnIIIW11O39; K4Si(H2O)MnIIIW11O39; or K5CoIIIW12O40. Another embodiment relates to a method for removing a contaminant from an environment, including contacting the polyoxometalate topical composition with the environment containing the contaminant for a sufficient time to remove the contaminant from the environment.
    Type: Application
    Filed: April 29, 2002
    Publication date: March 13, 2003
    Inventors: Craig L. Hill, Ling Xu, Jeffrey T. Rhule, Eric A. Boring
  • Patent number: 6528051
    Abstract: The methods and compositions of the present invention are directed to enhancing an immune response and increasing vaccine efficacy through the simultaneous or sequential targeting of specific immune system components. More particularly, specific immune components, such as macrophages, dendritic cells, B cells and T cells, are individually activated by component-specific immunostimulating agents. One such component-specific immunostimulating agent is an antigen-specific, species-specific monoclonal antibody. The invention is also directed to a method for the in vitro production of the antigen-specific, species-specific monoclonal antibodies which relies upon the in vitro conversion of blood-borne immune cells, such as macrophages and lymphocytes. Vaccine efficacy is enhanced by the administration of compositions containing component-specific immunostimulating agents and other elements, such as antigens or carrier particles, such as colloidal methods, such as gold.
    Type: Grant
    Filed: August 22, 2001
    Date of Patent: March 4, 2003
    Assignee: CytImmune Sciences, Inc.
    Inventors: Lawrence Tamarkin, Giulio F. Paciotti
  • Patent number: 6521264
    Abstract: A solid powder product with a Ca/P ratio of between 1.40 and 1.90 is prepared from tricalcium phosphate and tetracalcium phosphate. An aqueous solution containing calcium ions and phosphate ions with a Ca/P ratio higher than 0.20 and lower than 0.50 is prepared. The aqueous solution and the solid powder product and optionally water are mixed to obtain a mixture with a liquid/solid weight ratio of between 0.30 and 0.65 and a resulting paste with a Ca/P ratio of between 1.50 and 1.67.
    Type: Grant
    Filed: January 11, 2000
    Date of Patent: February 18, 2003
    Assignee: Teknimed
    Inventors: Jean-Louis Lacout, Zinèb Hatim, Michele Frache-Botton
  • Patent number: 6517848
    Abstract: Methods of using absorbent personal care articles, such a diapers and adult incontinent briefs, comprising an absorbent article and having disposed thereon a skin irritant sequestering effective amount of an unmodified particulate skin irritant sequestering agent, and a lipophilic skin health benefit agent are provided. An unmodified particulate skin irritant sequestering agent can be a clay, such as bentonite or laponite unmodified by organic amphiphilic compounds. A lipophilic skin health benefit agent can be stearic acid, isoparrafin, petrolatum, and a combination thereof. The skin irritant can be bound to the sequestering agent either on an individual's skin or on the absorbent article.
    Type: Grant
    Filed: December 30, 1999
    Date of Patent: February 11, 2003
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Linda Susan Huard, David John Tyrrell, David Roland Otts, Bernard Joseph Minerath, III, Brenda Marie Nelson, Chantel Spring Buhrow, Dennis Stein Everhart, Robert Cosmo DiLuccio, Frank Jerrel Akin
  • Patent number: 6506394
    Abstract: The present invention relates to a combination for surface treatment of a substrate, e.g. a nonwoven web, used in personal care product applications. The surface treatment combination not only provides adequate fluid handling properties, but also provides a topical delivery system effective in depositing a thin, tenacious and substantially continuous coating of a botanical extract on skin by an aqueous emulsion mediated dissolution of the agent from a substrate with subsequent transfer and deposition onto the skin. Coatings of the botanical extract on the skin resist removal, thereby preventing damage to the natural skin barrier and providing a protective barrier against chemically- and biochemically-induced skin damage.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: January 14, 2003
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Ali Yahiaoui, Dennis Stein Everhart, Wade Bolton May
  • Patent number: 6485733
    Abstract: Absorbent personal care articles, such a diapers and adult incontinent briefs, are provided comprising an absorbent article and having disposed thereon a skin irritant sequestering effective amount of an unmodified particulate skin irritant sequestering agent, and a lipophilic skin health benefit agent. An unmodified particulate skin irritant sequestering agent can be a clay, such as bentonite or laponite unmodified by organic amphiphilic compounds. A lipophilic skin health benefit agent can be stearic acid, isoparrafin, petrolatum, and a combination thereof. The skin irritant can be bound to the sequestering agent either on an individual's skin or on the absorbent article.
    Type: Grant
    Filed: December 30, 1999
    Date of Patent: November 26, 2002
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Linda Susan Huard, David John Tyrrell, David Roland Otts, Bernard Joseph Minerath, III, Brenda Marie Nelson, Chantel Spring Buhrow, Dennis Stein Everhart, Robert Cosmo DiLuccio, Frank Jerrel Akin
  • Patent number: 6475631
    Abstract: The present invention provides an antimicrobial agent consisting of glass which comprises 50 to 60 mole % of ZnO, 20 to 30 mole % of at least one member selected from the group consisting of B2O3 and P2O5, 1 to 10 mole % of at least one member selected from the group consisting of Al2O3 and ZrO2, 5 to 10 mole % of an alkali metal oxide and 0 to 15 mole % of SiO2 and an antimicrobial agent consisting of glass which comprises 50 to 70 mole % of ZnO, 20 to 35 mole % of P2O5, 0.5 to 10 mole % of Al2O3, 0.5 to 10 mole % of SnO2, 0 to 5 mole % of SiO2 and 5 to 10 mole % of an alkali metal oxide as well as an antimicrobial resin composition and antimicrobial artificial marble, each of which comprises a resin and the antimicrobial agent blended therewith. The antimicrobial resin composition and the antimicrobial artificial marble are excellent in their antimicrobial properties, resistance to color change and water resistance.
    Type: Grant
    Filed: July 14, 2000
    Date of Patent: November 5, 2002
    Assignee: Toagosei Co., Ltd.
    Inventors: Noriyuki Yamamoto, Koji Sugiura, Satoshi Yamato
  • Publication number: 20020160054
    Abstract: A composition for controlling growth of pathological organisms on a plant, said composition comprises an effective amount of one or more of metal ion(s); one or more of chelating agent(s); and phosphorous acid, and/or salt or hydrate thereof, said composition is in an agriculturally compatible carrier or vehicle.
    Type: Application
    Filed: January 29, 2002
    Publication date: October 31, 2002
    Inventor: Ran Lifshitz
  • Publication number: 20020110600
    Abstract: A composition for relief of symptoms of colds and influenza, containing, by weight, about 80-88% olive leaf extract powder containing oleuropein, about 5-10% neem leaf powder and up to about 8% of a homeopathic blend for symptom relief which preferably comprises aconitum napelius, belladonna, eupatorium perfoliatum, gelsemium sempervirens, Echinacea angustifolia and ferrum phosphoricum.
    Type: Application
    Filed: February 15, 2001
    Publication date: August 15, 2002
    Inventors: John Voorhees, Leslie Nachman
  • Publication number: 20020102893
    Abstract: Polyurethane elastomer yarns (particularly spandex) containing certain silver-based antimicrobial formulations therein are provided. This invention relates to polyurethane elastomer yarns (particularly spandex) containing certain silver-based antimicrobial formulations therein. Such formulations comprise antimicrobial compounds, such as, preferably, triclosan and/or silver-containing ion-exchange resins, such as zirconium phosphate, glass, and/or zeolite compounds. The inventive spandex yarns exhibit excellent antimicrobial qualities as well as surprisingly good anti-tack/frictional characteristics. As a result, antimicrobial spandex yarns are provided which exhibit ease in processing, particularly in further knitting, weaving, etc., to produce fabrics therefrom. Such fabrics are also encompassed within this invention.
    Type: Application
    Filed: December 4, 2000
    Publication date: August 1, 2002
    Inventors: Randy D. Petrea, Robert L. Schuette, Leland G. Close, Shirley Anne Whiteside
  • Patent number: 6420591
    Abstract: The present invention relates to novel carbamates and pharmaceutically acceptable salts thereof; compositions comprising the carbamate or a pharmaceutically acceptable salt thereof; and methods for treating cancer, inflammation, or a viral infection comprising administering to a patient in need of such treatment a therapeutically effective amount of the carbamate or pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 4, 2000
    Date of Patent: July 16, 2002
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventors: Tariq M Rana, Seongwoo Hwang, Natarajan Tamilarasu
  • Patent number: 6355277
    Abstract: There is disclosed a method of improving the smoke suppressant characteristics of halogen-containing polymeric compositions which comprises adding to said polymeric compositions a smoke retardant amount of (1) a complex of a cuprous halide and a phosphite, and (2) an amine molybdate which contains no residual molybdenum trioxide prepared by reacting an amine with molybdenum trioxide in an aqueous acidic medium under greater than atmospheric pressure and at a temperature of from 105-150° C.
    Type: Grant
    Filed: July 14, 2000
    Date of Patent: March 12, 2002
    Assignee: Unitex Chemical Corporation
    Inventors: James F. Day, Chad E. Lee
  • Patent number: 6352706
    Abstract: An ingestible mollusc poison contains a simple metal compound, an activity enhancing additive such as ethylene diamine disuccinic acid (EDDS) and derivatives thereof, and a carrier material edible to molluscs. In one embodiment the active agent of the mollusc poison may be in the form of a metal complex of EDDS. The composition may be used alone or in conjunction with molluscicidal co-active agents and/or fertilizers.
    Type: Grant
    Filed: February 1, 1999
    Date of Patent: March 5, 2002
    Assignee: W. Neudorff GmbH KG
    Inventor: George S. Puritch
  • Patent number: 6350474
    Abstract: The invention deals with phosphate water solution with cold solidification capacity. Phosphate composition containing iron oxide solution in acid, water, advantages from the following properties; it contains orthophosphorus acid and in addition metal powder. Phosphate composition is ecologically pure product, non toxic, non cancerogenic, non-allergic. It has antimicrobial, antivirus and fungicidal properties. Phosphate composition can be applied within medicine: surgery, dermatology, dentistry, oncology, pharmacology and other branches. In agriculture use: as a means of curing plant diseases, within veterinary—as a means for preventive maintenance and curing of animal diseases, within construction—as an anticorrosive, fire-resistant, hydro-electric isolating covers, ceramic tiles, concretes, which protect against radiation, as well as for producing other composite materials.
    Type: Grant
    Filed: June 7, 1999
    Date of Patent: February 26, 2002
    Inventors: David Dzneladze, Andro Dzneladze, Nargisa Jabishvili
  • Patent number: 6346279
    Abstract: An acidic aqueous hydrogen peroxid solution is provided, with improved disinfectant activity. Concentrated solutions preferably contain up to about 8% and as-used concentrations contain about 0.5% peroxide. The solution also contains from 0.1 to 5.0% of at least one acid compound, e.g. phosphoric and/or a phosphonate with from 1 to 5 phosphonic acid groups, and from 0.02 to 5% of at least one anionic surfactant. The surfactant is selected from C8 to C16-alkyl aryl sulphonic acids, sulphonated C12 to C22 carboxylic acids, C8 to C22-alkyl diphenyl oxide sulphonic acids, naphthalene sulphonic acids, C8 to C22 alkyl sulphonic acids, and alkali metal and ammonium salts thereof, and alkali metal C8 to C18 alkyl sulphates, and mixtures thereof. Most preferably the solution has an emulsifier, e.g. a salt of an alkylated diphenyl oxide. The solution may also contain corrosion inhibitors and/or lower alcohols.
    Type: Grant
    Filed: July 19, 1999
    Date of Patent: February 12, 2002
    Assignee: Virox Technologies, Inc.
    Inventor: Michael J. Rochon
  • Publication number: 20020015741
    Abstract: A composition for accelerating the disposal of ethanol from bodily fluid. Certain additives can accelerate the metabolic oxidation of ethanol, and others in addition act as catalysts or “pseudo” enzymes for the oxidation. Additives include the oxidant Nicotinamide Adenine Dinucleotide and a variety of other additives such as transition metal ions and complexes thereof which favor the oxidation reaction. The compositions described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.
    Type: Application
    Filed: June 7, 2001
    Publication date: February 7, 2002
    Inventors: Ward Beryl Bowen, Daniel Salman Daniel
  • Patent number: 6303155
    Abstract: A method for restoration of the circadian rhythm of parathyroid hormone (PTH) serum levels in a subject having osteoporosis, so as to restore a circadian rhythm of PTH levels which is similar to that existing in normal subjects is disclosed by administering a single daily dose of a composition consisting essentially of an effective amount of phosphate in the evening or at night, whereby the composition causes a circadian rhythm of PTH levels which peaks during the night, whereby the circadian rhythm of PTH levels is restored to that which is similar to that existing in normal subjects, thereby treating osteoporosis.
    Type: Grant
    Filed: March 1, 1999
    Date of Patent: October 16, 2001
    Assignee: Hadasit Medical Research Services and Development Company, Ltd.
    Inventor: Justin Silver
  • Patent number: 6277414
    Abstract: The present invention relates to an aqueous decontaminating composition comprising (A) an amount of H2O2 less than or equal to 60% by weight, based on the total weight of said composition; (B) an RCO3H/RCO2H mixture, where R is methyl or ethyl, as indicated above, said mixture being present in an amount such that the weight ratio of said mixture to the hydrogen peroxide is between 0.15/1 and 0.85/1; (C) a silver component as a source of Ag ions, selected from the group consisting of silver salts and complexes, said silver component being present in an amount such that the weight ratio of said silver component to the hydrogen peroxide is between 0.0005/1 and 0.015/1; (D) a stabilizer present in an amount such that the weight ratio of said stabilizer to the hydrogen peroxide is between 0.0005/1 and 0.025/1; and water to make up to 100% by weight. It further relates to the method of preparation and to the use of said composition.
    Type: Grant
    Filed: September 22, 1998
    Date of Patent: August 21, 2001
    Assignee: Sodifra
    Inventors: Alain Elhaik, Raphaël Alex De Nicola