Abstract: There is provided on-demand, oxygen generating topical compositions having a built-in indicator specifically to indicate a color change upon the complete mixing of the oxygen precursor and catalyst. The first part of the composition contains a carrier and manganese dioxide (MnO2) nanoparticles. The second part of the composition comprises the oxygen precursor; hydrogen peroxide. When the two parts, one with manganese dioxide nanoparticles and exhibiting a characteristic color, (e.g. yellow brown) and the second part with hydrogen peroxide are mixed together, the color imparted by the manganese dioxide nanoparticles essentially disappears and the final composition (enriched with oxygen) either appears colorless or takes on the original color of the catalyst. Thus, the manganese dioxide catalyst nanoparticles themselves serve as the colorimetric indicator of peroxide decomposition to oxygen, precluding the need for an external colorant.

Abstract: An aqueous disinfecting solution, a concentrated version of the solution, and a dry powdered composition which may be dissolved in water to provide the solution. The solution has a pH of from 0.6 to 7 and comprises (a) hydrogen peroxide in a concentration of from 0.01 to 6% w/w; and (b) at least one component chosen from cyclic carboxylic acids and aromatic alcohols, in a concentration of from 0.01 to 10% w/w, all based on the total weight of the solution. The cyclic carboxylic acids are preferably 2-furan carboxylic acid, benzoic acid and salicylic acid and the aromatic alcohol is preferably benzyl alcohol. Furthermore, the solution may contain surfactants, corrosion inhibitors, hydrotropes, cation sequestering agents, hydrogen peroxide stabilizers, solvents, thickeners, skin conditioning agents, antifoams, and pH buffers.

Abstract: This invention relates to the field of topical treatments for infections such as nail infections, particularly fungal infections of the nail commonly referred to as onychomycosis. Particularly, the invention relates to novel compositions containing peroxide for the treatment of such nail infections and other infections.

Abstract: The present invention relates to a dry type tooth-whitening patch comprising peroxide as a tooth whitening agent. In particular, disclosed is a dry type tooth-whitening patch in which peroxide is contained, as a teeth whitening agent, in a matrix type adhesive layer. The adhesive layer includes, as a base polymer thereof, a hydrophilic glass polymer, which provides a strong adhesion to teeth while releasing the tooth whitening agent when hydrated on the enamel layers of teeth in the moist oral cavity. The dry type patch according to the present invention is convenient in use, as compared to wet type patches. Further, it exhibits a superior adhesion while being maintained in a state attached to the teeth for a lengthened period of time so as to assure an enough contact time between the whitening agent in the patch and stains on the teeth, thereby giving a sufficient whitening effect.

Abstract: The present invention is drawn to compositions, systems, and methods of treating skin disease. In one example, the composition includes a peroxygen, a transition metal or alloy thereof, and optionally, an alcohol and/or a drug. The composition can be packaged as part of a two-part system.

Abstract: The invention provides a liquid composition containing (a) an acidic oxidant, (b) nitric acid or a salt thereof, and (c) at least one carboxylic acid selected from the group consisting of monocarboxylic acids, dicarboxylic acids, and tricarboxylic acids, or a salt thereof. The liquid composition can be used to disinfect or sterilize a subject that includes a portion made of an aluminum-based metal.

Abstract: A cleaning compound for cleaning surfaces that includes at least one container, with each container including a peroxide and/or an alkaline reactant therein. The alkaline reactant is selected to raise the pH of the cleaning compound into the alkaline range when the peroxide and the alkaline reactant are mixed together. The cleaning compound may be a liquid or dry compound, which is applied to the surface to be cleaned.

Abstract: An aqueous disinfecting solution having a pH from about 0.5 to about 6 and consisting essentially of hydrogen peroxide in a concentration from about 0.05 to about 8 w/w % of the total solution; at least one anionic surfactant in a concentration from about 0.02 to about 8 w/w % of the total solution, selected from sulfonated C12 to C22 carboxylic acids and alkali metal, ammonium, calcium and magnesium salts thereof; naphthalene sulfonic acids and alkali metal, ammonium, calcium and magnesium salts thereof; C8 to C22 alkyl sulfonic acids and alkali metal, ammonium, calcium and magnesium salts thereof; and alkyl or alkenyl esters or diesters of sulfosuccinic acids in which the alkyl or alkenyl groups independently contain from six to eighteen carbon atoms and alkali metal, ammonium, calcium and magnesium salts thereof; and benzyl alcohol in a concentration from about 0.1 to about 10 w/w % of the solution.

Abstract: There is provided a skin rejuvenation composition which comprises at least one oxidant, at least one photoactivator capable of activating the oxidant, and at least one healing factor chosen from hyaluronic acid, glucosamine and allantoin, in association with a pharmaceutically acceptable carrier.

Abstract: An improved beverage can includes a GRAS antimicrobial wipe contained in a low profile pouch that is adhered to the side of the can. The low profile pouch is constructed of a substantially planar substrate that retains the wipe directly to the exterior surface of the can. The pouch includes a perforated tab that is removed to access the wipe. To use, the perforated tab is ripped off, the user reaches into the pouch and pulls out the antimicrobial wipe, and wipes the can as desired, typically focusing on the drinking region of the can.

Abstract: There is provided wound healing composition which comprises at least one oxidant, at least one photoactivator capable of actuating the oxidant and at least one healing factor chosen from hyaluronic acid, glucosamine and allantoin in association with a pharmaceutically acceptable carrier. In addition, a method of topically treating wounds using at least one oxidant and at least one photoactivator capable of activating the oxidant followed by illumination of said photosensitizer is disclosed.

Abstract: In one embodiment, a disinfectant composition includes a peroxide, a peracid, an anionic surfactant, a nonionic polymer, and one or both of a linear fatty alcohol and an alkyl pyrrolidone. The disinfectants provide greater killing rates for microbial populations in short periods of time, and therefore can be considered to be fast-acting disinfectants.

Abstract: The present technology, in general, relates to antimicrobial and biocidal compositions, for example bucket dilutable biocidal compositions, and the various applications and/or processes of utilizing them as hard surface disinfectants and/or cleaners. The biocidal composition of the present technology comprises hydrogen peroxide, a quaternary ammonium compound, an appropriate acid and an amine oxide in specific concentrations to provide a 5 minute or less microbial contact kill time for at least one biocidal target.

Abstract: Methods have been developed for incorporation of a peracid compound into or on wound application matrices, such as bandages or dressings, and other matrices which will favorably impact wound healing and help eliminate microbial infection. The peracid compound comprises a base compound that is metabolically pertinent to wound healing, the oxidized form of the base compound (a peracid), and an appropriate oxidizer, such as hydrogen peroxide. In addition, other excipients with wound healing potential, such as esters of the base compound, may be added to the peracid compound. The combination peracid-wound application matrices can be used to disinfect and heal various wound types with designed time release of the peracid compound.

Abstract: The NSAID, sulindac and/or its metabolites and derivatives, in combination with hydrogen peroxide or another oxidizing agent, such as arsenic trioxide that generates reactive oxygen species (ROS), significantly enhances the killing of cancer cells. This effect occurs at concentrations of each compound that individually have little or no activity directed against cancer cells. A skin cream has been developed and used to treat skin cancer and precancerous skin growths that effectively removes the lesions with no effect on surrounding normal skin.

Abstract: A concentrated and one phase cleaning and disinfecting solution containing a sparingly soluble cyclic carboxylic acid. The solution has a pH of from about 0.05 to about 2, and comprises, consists essentially of, or consists of from about 2% w/w to about 8% w/w hydrogen peroxide; from about 5% w/w to about 20% w/w linear alkyl benzene sulfonic acid; from about 0.5% w/w to about 8% w/w of at least one sparingly soluble (i.e. a solubility in pure water at room temperature of less than 1% w/w) cyclic carboxylic acid, wherein the cyclic carboxylic acid is present in acid and salt form in a ratio of at least 9:1 (acid:salt); from about 2% w/w to about 10% w/w of at least one block copolymer surfactant (e.g. PLURONIC L62); and from about 4% w/w to about 15% w/w of at least one solvent.

Abstract: Methods of and compositions for producing and using plant-based materials are provided. The methods include using biopolymers or their synthetic equivalents combined with a stable source of reactive oxygen species that when applied to or combined with a separate source of oxido-reducing enzyme or catalyst will cause the formation of an activated biopolymer with increased protein binding affinity and microbial control activities.

Abstract: The present application relates to novel antimicrobial compositions and methods of using said antimicrobial compositions for inhibiting and treating microbial growth, microbial infections, inflammatory diseases, viral diseases, cardiovascular diseases, diabetes and/or conditions that may be regulated or associated with microbial infections, such as cancer.

Abstract: The present application relates to novel antimicrobial compositions and methods of using said antimicrobial compositions for inhibiting and treating microbial growth, microbial infections, inflammatory diseases, viral diseases, cardiovascular diseases, diabetes and/or conditions that may be regulated or associated with microbial infections, such as cancer.

Abstract: Methods for reducing thermophilic spore-forming bacteria that can lead to off-odors and tastes in beverage products, especially fruit or vegetable juice products, are provided. The methods employ one or more peroxy acids that are added to the beverage handling system prior to pasteurization and concentration of the beverage product. Particularly, the peroxy acid is added prior to final filtration of the beverage product upstream of the pasteurizer and concentrator.

Abstract: The present invention relates to aqueous compositions of associative polyelectrolyte complexes (PECs), optionally containing surfactants, biocidal agents and/or oxidants, which can provide surface protection to treated articles including reduced soiling tendency, reduced cleaning effort and improved soil repellancy, as well as providing bacteriostatic properties to treated surfaces that thereby gain resistance to water, environmental exposure and microbial challenge. Treatment means and compositions are provided that employ associative polyelectrolyte complexes formed by combining a water soluble cationic first polyelectrolyte with a water soluble second polyelectrolyte bearing groups of opposite charge to the first polyelectrolyte under suitable mixing conditions where the one polyelectrolyte present in molar excess is added in the form of a first aqueous solution during a mixing step to a second aqueous solution comprising the oppositely charged polyelectrolyte present in molar deficiency.

Abstract: Described herein is a pharmaceutical composition for treating a subject having a cancer and/or myeloproliferative disorder associated with overexpression of a HOXA1 gene product where an effective amount of at least one miR-10a gene product or an isolated variant or biologically-active fragment thereof is administered to the subject sufficient to decrease expression of the HOXA1 gene product in the subject.

Abstract: An aqueous skin disinfecting solution has a pH of from about 2 to about 6, and consists of at least (a) hydrogen peroxide in a concentration of from about 0.01 to about 4% w/w; (b) at least one surfactant chosen from alkyl betaines, alkyl amidopropyl betaines, alkyl amidopropyl betaine amides, alkylsulfobetaines, alkyl amphocarboxylates and amine oxides in a concentration of from about 0.01 to about 15% w/w; (c) at least one hydrogen peroxide stabilizer in a concentration of from about 0.01 to about 4% w/w; (d) at least one member chosen from cyclic carboxylic acids and salts thereof in a concentration of from about 0.01 to about 4% w/w; (e) at least one skin conditioning agent in a concentration of from about 0.01 to about 10% w/w; and (f) an effective amount of at least one solvent. The invention can be provided in concentrated or dried powdered form.

Abstract: A method is provided for the microbicidal treatment of a surface such as sanitization, disinfection, sterilization, and decontamination of a surface or object by use of an anti-microbial composition comprising an aqueous solution of peracetic acid and hydrogen peroxide with acetic acid, water soluble polymer containing lactam, and phosphate ester surfactant and little or no stabilizer, and according to the method enhanced microbicidal efficacy is obtained when the composition is applied onto a surface as a thin film wetting the surface so that a shorter contact time for a desired fractional reduction in microbial population is obtained Still further, the compositions comprise photosensitizer for light-activated anti-microbial efficacy.

Abstract: An antimicrobial composition useful for microbial reduction on food includes an oxidizer and an acid component. The oxidizer includes hydrogen peroxide and/or peroxyacetic acid. The acid component includes one or more inorganic acids or their salts. For example, the acid component may be selected from sodium acid sulfate, sulfuric acid, hydrochloric acid, phosphoric acid, sulfamic acid, nitric acid, hydrofluoric acid, or combinations thereof. In certain embodiments, the antimicrobial composition additionally includes one or more surfactants. A method of reducing microbes on food includes applying to the food the above-described antimicrobial composition.

Abstract: The present invention provides ?-keto alkylperacids and methods for producing and using the same. In particular, ?-keto alkylperacids are useful as antimicrobial agents.

Abstract: Oral care compositions comprising: (a) a peroxide complex comprising a peroxide component and an N-vinyl heterocyclic polymer (e.g., poly-N-vinyl polylactam, or poly-N-vinyl-polyimide); (b) a whitening agent (e.g., hydrogen peroxide); and (c) an orally acceptable carrier. In one embodiment, the carrier comprises a film forming material. Methods are also provided for making an oral care composition comprising: (a) mixing a whitening agent, silicone adhesive and carrier fluid to form a homogenous mixture; (b) adding a peroxide complex to said homogenous mixture, wherein said complex comprises hydrogen peroxide and an N-vinyl heterocyclic polymer; and (c) mixing under vacuum.

Abstract: A medical treatment kit and methods of use thereof is provided. The kit includes a container, two or more chambers within the container, an antiseptic agent disposed in one of the chambers, a cleansing agent disposed in a separate chamber and an applicator. The agents are not contacted until immediate use of the kit is required. The medical treatment kit is used to administer an antiseptic shampoo or other medical composition to a patient with an open wound or injury. The kit is designed to be simple to use in an emergency situation. The kit is also designed to deliver medical compositions that are at the peak of potency.

Abstract: Gel comprising reactive oxidant release agent The invention provides a gel composition comprising 5% to 75% w/w of an inorganic gelling agent other than silica based gelling agents, 0.5-60% w/w, preferably 0.5 to 30% w/w, of an inorganic oxidant release agent and at least 20% w/w of water, and possibly a stabilizer. It further provides a process for making same, comprising preparing a first solution of a dibasic phosphate salt in water comprising dissolved oxidant release agent, preparing a second and solution of a alkaline earth metal salt in water comprising dissolved oxidant release agent, and mixing both, first and second solutions, in a ratio of 1 to 1 to 10 to 1, followed by a concentration step. The gel composition of the invention is suitable for soil, sediment groundwater or water remediation purposes and disinfection or wound healing purposes.

Abstract: The present invention provides ?-keto peracids and methods for producing and using the same. In particular, ?-keto peracids are useful as antimicrobial agents.

Abstract: An anti-microbial preservative for use in ophthalmic and dermatologic products. The preservative includes from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Additionally, the preservative does not generate chlorine dioxide within the pH range of 5.0-8.8. Also included are an antimicrobial ophthalmic and dermatologic compositions for direct application onto an eye or skin of a living being including from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Also included are methods for treating dryness of the eyes and skin disorders (e.g., wounds, burns, infections, ulcerations, psoriasis, etc.) and for disinfecting and cleansing contact lenses while in place upon an eye by applying the composition to the eye or to the contact lens.

Abstract: A dental tray with a hydrophobic tooth whitening formulation where the tooth whitening formulation is substantially non-water soluble, and a method of using this dental tray to whiten the teeth. The tooth whitening formulation is primarily comprised of a hydrophobic polymer and a peroxide or a peroxide yielding compound. Preferably the hydrophobic polymer is the condensation product of a silicone resin and an organosiloxane. The dental tray is formed to encompass the front and the rear surfaces of the teeth. The dental tray is comprised of a thermoplastic or thermoset polymer. The teeth whitening formulation is placed into the dental tray and the tray placed against the teeth to be whitened. This is for a sufficient period of time to at least partially whiten teeth. This can be a period of time from about 0.5 hour to 2 hours or more.

Abstract: Compositions and methods to inhibit adverse physiological effects caused by resin-based and resin-containing materials are disclosed. More specifically, the use of N-acetyl-cysteine (NAC) to inhibit hydroxyethyl methacrylate (HEMA)-mediated cell death and cytotoxicity.

Abstract: Food handling facilities such as meat packing, plants, dairies, kitchens and the like are disinfected using a disinfecting atmosphere which includes ozone and hydrogen peroxide, at a relative humidity of at least 60%.

Abstract: A method of moisturizing while decolonizing mammalian tissue, the method comprising applying a multi-valent cationic antiseptic composition to the tissue, and applying a moisturizer composition to at least a portion of the same tissue; wherein the mammalian tissue is oral tissue of a subject; wherein the multi-valent cationic antiseptic is other than a metal ion; and wherein the applied compositions essentially exclude any component which causes a precipitate when combined with a multi-valent cationic antiseptic contained in the multi-valent cationic antiseptic composition when tested according to Test Method F, and/or wherein the moisturizer composition is such that a log reduction in the number of viable bacterial cells of at least 2 is provided when 106 cfu of Pseudomonas aeruginosa are combined with a mixture 1.1 g of the moisturizer composition and 1.5 g of the multi-valent cationic antiseptic composition containing 0.

Abstract: An anti-microbial preservative for use in ophthalmic and dermatologic products. The preservative includes from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Additionally, the preservative does not generate chlorine dioxide within the pH range of 5.0-8.8. Also included are an antimicrobial ophthalmic and dermatologic compositions for direct application onto an eye or skin of a living being including from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Also included are methods for treating dryness of the eyes and skin disorders (e.g., wounds, burns, infections, ulcerations, psoriasis, etc.) and for disinfecting and cleansing contact lenses while in place upon an eye by applying the composition to the eye or to the contact lens.

Abstract: The invention relates to a composition, particularly in the form of liquid to be used externally as a rinsing contact lenses, containing nanocrystalline photocatalyst active in visible light, and optionally hydrogen peroxide.

Abstract: An improved method and apparatus for producing a stable, non-toxic, antimicrobial electrolyzed saline solution with a broad range of anti-infective and therapeutic applications. The resulting electrolyzed saline solution exhibits a marked lack of toxicity upon intravenous, aspired, oral or topical application in mammals for therapeutic applications providing a broad platform, including topical disinfection, antimicrobial application, wound treatment, oxidative stress reduction and enhancement of immune function to better detect malfunctioning cells.

Abstract: The present invention relates to a new and inventive composition for implant cleaning and/or debridement of hard surfaces in the oral cavity, which comprises optimally activated nanoparticles of TiO2, having a mean particle diameter (D50) of about 10-100 nm at a concentration between 0.5-500 g/L, and H2O2, at a concentration of at the most 7.5% by volume, said composition being antibacterial, without causing microbial resistance, and anti-inflammatory, and wherein said composition further comprises solid microparticles, having a mean particle diameter (D50) of about 100-200 ?m at a concentration between 0.5-300 g/L, for improved mechanical debridement and/or cleaning of rough surfaces in the oral cavity and/or on an implant.

Abstract: The present invention is directed to a method of inhibiting aconitase activity of fungal cells in an individual, the method comprising administering an inhibitor of aconitase activity to the fungal cell in an amount effective to inhibit activity of aconitase by said fungal cells.

Abstract: The present invention provides compositions and methods for treating deep partial thickness or full thickness wounds or injuries. The present invention also provides compositions and methods for promoting healing and regeneration of impaired or damaged tissue at a site of such partial thickness or full thickness wounds or injuries, as well as promoting vascularization and angiogenesis in regenerating and/or supportive tissue at such sites.

Abstract: The present technology, in general, relates to antimicrobial and biocidal compositions, for example bucket dilutable biocidal compositions, and the various applications and/or processes of utilizing them as hard surface disinfectants and/or cleaners. The biocidal composition of the present technology comprises hydrogen peroxide, a quaternary ammonium compound, an appropriate acid and an amine oxide in specific concentrations to provide a 5 minute or less microbial contact kill time for at least one biocidal target.

Abstract: The present invention relates to the use of compounds of formula wherein the variables are as defined in the description, in the free form or in salt form, for controlling sea lice on fish.

Abstract: Disinfectant compositions include 0.001 to 10% by weight of hydrogen peroxide or a hydrogen peroxide source based on the total weight of the composition; 0.001 to 20% by weight of at least one amphoteric surfactant based on the total weight of the composition; and 0.001 to 0.8% by weight of at least one alkali metal or alkaline earth metal salt of a cyclic or heterocyclic aromatic compound comprising at least one hydroxyl group, carboxylic group, or combination thereof based on the total weight of the composition. The disinfectant compositions are particularly effective at treating surfaces contaminated with resistant bacteria, such as Staphylococcus aureus at a fast killing rate.

Abstract: Disinfectant compositions include 0.001 to 10% by weight of hydrogen peroxide or a hydrogen peroxide source based on the total weight of the composition; 0.001 to 20% by weight of at least one amphoteric surfactant based on the total weight of the composition; and 0.001 to 15% by weight of at least one alkali metal or alkaline earth metal salt of a cyclic or heterocyclic aromatic compound comprising at least one hydroxyl group, carboxylic group, or combination thereof based on the total weight of the composition. The disinfectant compositions are particularly effective at treating surfaces contaminated with resistant bacteria, such as Staphylococcus aureus at a fast killing rate.

Abstract: Disclosed are a two-agent type disinfectant composition for hard articles, which includes a first agent containing a powder mixture (A) and a second agent containing an aqueous hydrogen peroxide solution (B-1), the powder mixture (A) containing an alkali metal salt (A-1) exhibiting basicity when the salt is in the form of an aqueous solution, a water-soluble copper salt (A-2), a compound (A-3) represented by the following formula (1), and a nonionic surfactant (A-4) represented by the following formula (2), and in which the molar ratio of the water-soluble copper salt (A-2) and the compound (A-3) represented by the mixing amount of (A-3)/mixing amount of (A-2) is 3.

Abstract: The present invention relates to the use of combinations of 4-bromo-2-(4-chloro-phenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile and an oxidizing agent, for eradicating, eliminating or reducing aquatic organisms in ballast water or bilge water whereby 4-bromo-2-(4-chloro-phenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile and the oxidizing agent are in respective proportions to provide a synergistic effect against fouling organisms. Suitable oxidizing agents are e.g.

Abstract: Methods of incorporating an antioxidant into a medical device including a polymer are described, and methods of packaging medical devices.

Abstract: The present invention provides an antiviral composition and system for using the same, wherein the antiviral composition includes between about 0.1 to about 0.3 wt % of antimicrobial agent such as benzalkoniumchloride, between about 0.1 to about 1 wt % of chlorinated phenol compound, such as parachlorometaxylenol, between about 0.1 to about 3 wt % of hydrogen peroxide, and at least about 60 wt % aqueous solvent.

Abstract: This relates to a method to generate a mixture of Hydrogen Peroxide gas and a Carrier gas, consisting in passing a dry Carrier gas through a solution of Hydrogen Peroxide.